Marco Matucci Cerinic

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi request reprint Angiotensin-converting enzyme in systemic sclerosis: from endothelial injury to a genetic polymorphism
    Serena Guiducci
    Division of Medicine I and Rheumatology, Villa Monna Tessa, Viale Pieraccini 18, 50139, Florence, Italy
    Ann N Y Acad Sci 1069:10-9. 2006
  2. ncbi request reprint Heart involvement in autoimmune rheumatic diseases: the "phantom of the opera"
    M Matucci-Cerinic
    Department of Medicine and Surgery, Division of Medicine I and Rheumatology University of Florence, AOUC, Florence, Italy
    Rheumatology (Oxford) 45:iv1-3. 2006
  3. ncbi request reprint Macrovascular involvement in systemic sclerosis: comorbidity or accelerated atherosclerosis?
    Jelena Blagojevic
    Department of Medicine and Surgery, Division of Medicine I and Rheumatology, University of Florence, Villa, Monna Tessa, Viale Pieraccini 18, 50139 Firenze, Italy
    Curr Rheumatol Rep 9:181-2. 2007
  4. pmc Cyclophosphamide in systemic sclerosis: still in search of a 'real life' scenario
    Irene Miniati
    Department of Biomedicine, Division of Rheumatology AOUC, Denothe Center, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy
    Arthritis Res Ther 11:103. 2009
  5. pmc International cohort study of 73 anti-Ku-positive patients: association of p70/p80 anti-Ku antibodies with joint/bone features and differentiation of disease populations by using principal-components analysis
    Katja Lakota
    Department of Rheumatology, University Medical Centre, Ljubljana, Slovenia
    Arthritis Res Ther 14:R2. 2012
  6. pmc Systemic sclerosis-associated pulmonary hypertension: why disease-specific composite endpoints are needed
    Christopher P Denton
    Centre for Rheumatology, Royal Free Campus, University College Medical School, London, NW3 2PF, UK
    Arthritis Res Ther 13:114. 2011
  7. pmc Raloxifene reduces urokinase-type plasminogen activator-dependent proliferation of synoviocytes from patients with rheumatoid arthritis
    S Guiducci
    Division of Rheumatology, Department of Internal Medicine, University of Florence, Florence, Italy
    Arthritis Res Ther 7:R1244-53. 2005
  8. pmc A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patients
    Betti Giusti
    Department of Medical and Surgical Critical Care DENOTHE, University of Florence, Florence, Italy
    Arthritis Res Ther 8:R115. 2006
  9. doi request reprint The challenge of early systemic sclerosis for the EULAR Scleroderma Trial and Research group (EUSTAR) community. It is time to cut the Gordian knot and develop a prevention or rescue strategy
    M Matucci-Cerinic
    Department of Biomedicine, Division of Rheumatology AOUC, Villa Monna Tessa, Viale Pieraccini 18, Florence I 50139, Italy
    Ann Rheum Dis 68:1377-80. 2009
  10. doi request reprint The complexity of managing systemic sclerosis: screening and diagnosis
    M Matucci-Cerinic
    Department of Biomedicine, Division of Rheumatology, Centre DenoThe, AOUC University of Florence, Florence, Italy
    Rheumatology (Oxford) 48:iii8-13. 2009

Detail Information

Publications51

  1. ncbi request reprint Angiotensin-converting enzyme in systemic sclerosis: from endothelial injury to a genetic polymorphism
    Serena Guiducci
    Division of Medicine I and Rheumatology, Villa Monna Tessa, Viale Pieraccini 18, 50139, Florence, Italy
    Ann N Y Acad Sci 1069:10-9. 2006
    ....
  2. ncbi request reprint Heart involvement in autoimmune rheumatic diseases: the "phantom of the opera"
    M Matucci-Cerinic
    Department of Medicine and Surgery, Division of Medicine I and Rheumatology University of Florence, AOUC, Florence, Italy
    Rheumatology (Oxford) 45:iv1-3. 2006
  3. ncbi request reprint Macrovascular involvement in systemic sclerosis: comorbidity or accelerated atherosclerosis?
    Jelena Blagojevic
    Department of Medicine and Surgery, Division of Medicine I and Rheumatology, University of Florence, Villa, Monna Tessa, Viale Pieraccini 18, 50139 Firenze, Italy
    Curr Rheumatol Rep 9:181-2. 2007
  4. pmc Cyclophosphamide in systemic sclerosis: still in search of a 'real life' scenario
    Irene Miniati
    Department of Biomedicine, Division of Rheumatology AOUC, Denothe Center, University of Florence, Viale Pieraccini 18, 50139 Florence, Italy
    Arthritis Res Ther 11:103. 2009
    ..Further RCTs on early SSc are needed to assess the real efficacy of CYC in inducing remission and increasing survival...
  5. pmc International cohort study of 73 anti-Ku-positive patients: association of p70/p80 anti-Ku antibodies with joint/bone features and differentiation of disease populations by using principal-components analysis
    Katja Lakota
    Department of Rheumatology, University Medical Centre, Ljubljana, Slovenia
    Arthritis Res Ther 14:R2. 2012
    ....
  6. pmc Systemic sclerosis-associated pulmonary hypertension: why disease-specific composite endpoints are needed
    Christopher P Denton
    Centre for Rheumatology, Royal Free Campus, University College Medical School, London, NW3 2PF, UK
    Arthritis Res Ther 13:114. 2011
    ..Failure to take this into account may compromise progress in managing PAH in SSc...
  7. pmc Raloxifene reduces urokinase-type plasminogen activator-dependent proliferation of synoviocytes from patients with rheumatoid arthritis
    S Guiducci
    Division of Rheumatology, Department of Internal Medicine, University of Florence, Florence, Italy
    Arthritis Res Ther 7:R1244-53. 2005
    ..RAL exerts anti-proliferative and anti-invasive effects on synoviocytes, mainly modulating u-PAR and, to a lesser extent, u-PA and PAI-1 levels, and inhibiting cell migration and proliferation...
  8. pmc A model of anti-angiogenesis: differential transcriptosome profiling of microvascular endothelial cells from diffuse systemic sclerosis patients
    Betti Giusti
    Department of Medical and Surgical Critical Care DENOTHE, University of Florence, Florence, Italy
    Arthritis Res Ther 8:R115. 2006
    ..These observations indicate that microvascular endothelial cells of patients with SSc show abnormalities in a variety of genes that are able to account for defective angiogenesis...
  9. doi request reprint The challenge of early systemic sclerosis for the EULAR Scleroderma Trial and Research group (EUSTAR) community. It is time to cut the Gordian knot and develop a prevention or rescue strategy
    M Matucci-Cerinic
    Department of Biomedicine, Division of Rheumatology AOUC, Villa Monna Tessa, Viale Pieraccini 18, Florence I 50139, Italy
    Ann Rheum Dis 68:1377-80. 2009
    ..Only after prospective studies can these potential criteria be considered validated. The consensus on criteria for the classification of very early SSc might be part of the evolving EULAR/ACR project of reclassification of SSc...
  10. doi request reprint The complexity of managing systemic sclerosis: screening and diagnosis
    M Matucci-Cerinic
    Department of Biomedicine, Division of Rheumatology, Centre DenoThe, AOUC University of Florence, Florence, Italy
    Rheumatology (Oxford) 48:iii8-13. 2009
    ..Nail-fold capillaroscopy is a promising tool for SSc assessment and may provide useful diagnostic and prognostic information, although further research is required to clarify its role in evaluating disease evolution...
  11. pmc Nerve growth factor and neuropeptides circulating levels in systemic sclerosis (scleroderma)
    M Matucci-Cerinic
    Department of Medicine, Division of Rheumatology, University of Florence, Italy
    Ann Rheum Dis 60:487-94. 2001
    ..To determine the circulating levels of nerve growth factor (NGF), neuropeptide Y (NPY), and vasoactive intestinal peptide (VIP) in systemic sclerosis (SSc), and to correlate these levels with clinical and laboratory features...
  12. pmc Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial
    Marco Matucci-Cerinic
    Department of Biomedicine, Division of Rheumatology, Denothe Center, University of Florence, Florence, Italy
    Ann Rheum Dis 70:32-8. 2011
    ....
  13. ncbi request reprint Therapy of spondylarthropathy in inflammatory bowel disease
    S Generini
    Department of Internal Medicine, Section of Rheumatology, University of Florence, Italy
    Clin Exp Rheumatol 20:S88-94. 2002
    ..New combination therapies and novel biologically-driven treatments, targeted to specific pathophysiological processes, might offer less toxicity and the potential for better treatment outcomes...
  14. pmc Clinical trials in systemic sclerosis: lessons learned and outcomes
    Marco Matucci-Cerinic
    Division of Medicine and Surgery, Division of Medicine I and Rheumatology, Villa Monna Tessa, Viale Pieraccini, I 50139 Florence, Italy
    Arthritis Res Ther 9:S7. 2007
    ....
  15. ncbi request reprint Blood coagulation, fibrinolysis, and markers of endothelial dysfunction in systemic sclerosis
    Marco Matucci Cerinic
    Department of Medicine, Division of Rheumatology, University of Florence, Italy
    Semin Arthritis Rheum 32:285-95. 2003
    ..To evaluate the coagulative/fibrinolytic cascade and the circulating markers of the endothelial injury in systemic sclerosis (SSc)...
  16. ncbi request reprint Assessment of lung involvement
    M Matucci-Cerinic
    Department of Medicine, Section of Rheumatology, University of Florence, Italy
    Clin Exp Rheumatol 21:S19-23. 2003
    ..Two core sets of variables are provided: the first concerns interstitial lung disease; the second pulmonary vascular disease...
  17. ncbi request reprint Vascular injury in systemic sclerosis: angiotensin-converting enzyme insertion/deletion polymorphism
    Cinzia Fatini
    Department of Medicine, Section of Rheumatology, University of Florence, Villa Monna Tessa, Viale Pieraccini 18, 50122 Firenze, Italy
    Curr Rheumatol Rep 6:149-55. 2004
    ..The discrepancy between the high prevalence of D allele and reduced ACE plasma levels in SSc demonstrate the lack of knowledge on the regulation and function of renin-angiotensin system in SSc...
  18. doi request reprint Bone marrow-derived mesenchymal stem cells from early diffuse systemic sclerosis exhibit a paracrine machinery and stimulate angiogenesis in vitro
    Serena Guiducci
    Department of Biomedicine, Division of Rheumatology, AOUC, Excellence Centre for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
    Ann Rheum Dis 70:2011-21. 2011
    ....
  19. ncbi request reprint Flow-mediated vasodilation and carotid intima-media thickness in systemic sclerosis
    Francesca Bartoli
    Department of Medicine and Surgery, Division Medicine 1 and 2 and Rheumatology, Villa Monna Tessa, University of Florence, Florence, Italy
    Ann N Y Acad Sci 1108:283-90. 2007
    ..Prospective studies including also clinical outcomes are needed to assess the features and significance of macrovacular involvement in SSc...
  20. doi request reprint Progressive loss of lymphatic vessels in skin of patients with systemic sclerosis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Viale G B Morgagni 85, I 50134, Florence, Italy
    J Rheumatol 38:297-301. 2011
    ..Our aim was to evaluate dermal lymphatic vessels in patients with SSc according to different phases of skin involvement...
  21. pmc Reduced circulating levels of angiotensin-(1--7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control
    Alberto Pignone
    Department of Medicine and Surgery, Division of Medicine I and II and Rheumatology, Villa Monna Tessa, University of Florence, Florence, Italy
    Ann Rheum Dis 66:1305-10. 2007
    ..Our aim was to assess, in patients with SSc, circulating levels of Ang I, Ang II and Ang-(1-7), with their metabolising enzymes ACE and NEP, and levels of NO and PGI2, and to correlate them to the main characteristics of SSc...
  22. ncbi request reprint Exercise Doppler echocardiography identifies preclinic asymptomatic pulmonary hypertension in systemic sclerosis
    Alberto Pignone
    Department of Medicine, Division of Rheumatology, University of Florence, Florence, Italy
    Ann N Y Acad Sci 1108:291-304. 2007
    ..0125; r2 = 0.2029). Ex-echo identifies a cluster of SSc patients with subclinical PAH that may develop PAH. This group should be followed up and may be considered for specific therapies to prevent disease evolution...
  23. doi request reprint Overexpression of VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, leads to insufficient angiogenesis in patients with systemic sclerosis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Viale G B Morgagni 85, Florence, Italy
    Circ Res 109:e14-26. 2011
    ....
  24. doi request reprint Efficacy of connective tissue massage and Mc Mennell joint manipulation in the rehabilitative treatment of the hands in systemic sclerosis
    Susanna Maddali Bongi
    Department of Biomedicine, Division of Rheumatology, AOUC, Denothe Centre, University of Florence, Florence, Italy
    Clin Rheumatol 28:1167-73. 2009
    ..This combined treatment may lead to an improvement of hand function and quality of life...
  25. doi request reprint Manual lymph drainage improving upper extremity edema and hand function in patients with systemic sclerosis in edematous phase
    Susanna Maddali Bongi
    Careggi Hospital Azienda Ospedaliero Universitaria Careggi, University of Florence, Florence, Italy
    Arthritis Care Res (Hoboken) 63:1134-41. 2011
    ..Our aim was to evaluate the efficacy of MLD in reducing edema and in improving functionality of the hands and perceived quality of life (QOL) in SSc patients in edematous phase...
  26. doi request reprint Ultrasound discloses entheseal involvement in inactive and low active inflammatory bowel disease without clinical signs and symptoms of spondyloarthropathy
    Francesca Bandinelli
    Department of Biomedicine, Division of Rheumatology, University of Florence, Florence, Italy
    Rheumatology (Oxford) 50:1275-9. 2011
    ..To investigate the presence of lower limb entheseal abnormalities in IBD patients without clinical signs and symptoms of SpA and their correlation with IBD clinical variables...
  27. doi request reprint Lung ultrasound for the screening of interstitial lung disease in very early systemic sclerosis
    Tatiana Barskova
    Department of Biomedicine, Division of Rheumatology, AOUC, Excellence Centre for Research, Transfer and High Education DENOthe, University of Florence, Via Pieraccini, 18 50139, Firenze, Italy
    Ann Rheum Dis 72:390-5. 2013
    ..Promising data have recently shown that lung ultrasound (LUS) is able to detect ILD by the evaluation of B-lines (previously called ultrasound lung comets), the sonographic marker of pulmonary interstitial syndrome...
  28. ncbi request reprint Hemorheologic profile in systemic sclerosis: role of NOS3 -786T > C and 894G >T polymorphisms in modulating both the hemorheologic parameters and the susceptibility to the disease
    Cinzia Fatini
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Arthritis Rheum 54:2263-70. 2006
    ..We undertook this study to investigate the hemorheologic profile in SSc and the role of NOS3 polymorphisms in modulating the hemorheologic status of SSc patients...
  29. ncbi request reprint The genetics of systemic sclerosis: an update
    Eloisa Romano
    Department of Biomedicine, Division of Rheumatology, University of Florence, AOUC, Florence, Italy
    Clin Exp Rheumatol 29:S75-86. 2011
    ..We also discuss the most relevant data obtained in genetic association studies of large populations that included a replication strategy, or studies for which independent replication was available...
  30. ncbi request reprint Microparticles and Kawasaki disease: a marker of vascular damage?
    Serena Guiducci
    Department of Biomedicine, Division of Rheumatology, Denothe Centre, University of Florence, Florence, Italy
    Clin Exp Rheumatol 29:S121-5. 2011
    ..Microparticles (MPs) are increased in diseases characterised by endothelial injury. Kawasaki disease (KD) damages the endothelium provoking life-threatening involvement of coronary arteries...
  31. ncbi request reprint Neprilysin levels in plasma and synovial fluid of juvenile idiopathic arthritis patients
    Gabriele Simonini
    Rheumatology Unit, Department of Pediatrics, University of Florence, Via Pico della Mirandola 24, 50132 Florence, Italy
    Rheumatol Int 25:336-40. 2005
    ..In 20 subjects requiring local steroid injection, NEP was measured in synovial fluid...
  32. doi request reprint Systemic sclerosis and infections
    Silvia Bellando Randone
    Department of Biomedicine, Denothe Centre, Division of Rheumatology AOUC, University of Florence, Florence, Italy
    Autoimmun Rev 8:36-40. 2008
    ..In SSc viral products could synergize with other factors in the microenvironment predisposing to SSc development...
  33. doi request reprint Evidence for reduced angiogenesis in bone marrow in SSc: immunohistochemistry and multiparametric computerized imaging analysis
    Valentina Carrai
    Department of Haematology, Careggi Hospital, Largo Brambilla 3, Florence, Italy
    Rheumatology (Oxford) 51:1042-8. 2012
    ..The aim of this study is to evaluate, in SSc BM, angiogenesis, cellular immune system and fibrosis...
  34. doi request reprint Musculoskeletal involvement in systemic sclerosis
    Silvia Bellando Randone
    Department of Biomedicine DENOThe Centre, Division of Rheumatology AOUC, University of Florence, Italy
    Best Pract Res Clin Rheumatol 22:339-50. 2008
    ....
  35. ncbi request reprint Vascular complications of scleroderma
    Serena Guiducci
    Division of Medicine I and Rheumatology, Department of Medicine and Surgery, AOUC, University of Florence, Florence, Italy
    Autoimmun Rev 6:520-3. 2007
    ..SSc has a high case-specific mortality due to organ-based complications including PAH, lung fibrosis, renal failure and involvement of the gastrointestinal tract...
  36. ncbi request reprint Rheumatological manifestations in diabetes mellitus
    Angela Del Rosso
    Department of Medicine, Division of Medicine I and Rheumatology, University of Florence, Viale G Pieraccini, 18 50139 Florence, Italy
    Curr Diabetes Rev 2:455-66. 2006
    ..Among bone conditions, osteopenia and osteoporosis may occur early in type 1 diabetes. Contrarily, in type 2 diabetes, bone mineral density is similar or, sometimes, higher than in non diabetic subjects, probably due to hyperinsulinemia...
  37. doi request reprint The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis
    Mirko Manetti
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Viale G B Morgagni 85, 50134 Florence, Italy
    Ann Rheum Dis 69:598-605. 2010
    ..Interleukin 33 (IL33) is a novel member of the IL1 family that promotes Th2 responses and inflammation through the ST2 receptor. IL33 is also a chromatin-associated transcriptional regulator in ECs...
  38. ncbi request reprint Overlap syndromes
    Ginevra Fiori
    Section of Rheumatology, Department of Medicine, University of Florence, Villa Monna Tessa, Viale Pieraccini 18, 50139 Firenze, Italy
    Reumatizam 49:12-5. 2002
    ..Finally, when a person has symptoms of various connective tissue diseases without meeting the full criteria for any one of them, it is often called Undifferentiated Connective Tissue Disease...
  39. ncbi request reprint Angioedema and systemic sclerosis. A review of the literature
    Luca Bertinotti
    Department of Internal Medicine, Section of Rheumatology, Nephrology, and Headache, Florence, Italy
    Scand J Rheumatol 31:178-80. 2002
    ..A review of the literature and possible correlated pathogenetic mechanisms are presented...
  40. ncbi request reprint Systemic lupus erythematosus (SLE) in Italy: an Italian prevalence study based on a two-step strategy in an area of Florence (Scandicci-Le Signe)
    Maurizio Benucci
    Rheumatology Unit ASL 10 Florence, Florence, Italy
    Med Sci Monit 11:CR420-5. 2005
    ..The goal was to ascertain the prevalence of SLE in the population over 18 years of age in the Scandicci-Le Signe area of Florence, Italy, based on the records of general practitioners (GPs)...
  41. doi request reprint Scenes from the past: the Medici Project: radiographic survey
    Natale Villari
    Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Radiographics 29:2101-14. 2009
    ....
  42. ncbi request reprint Good clinical response, remission, and predictors of remission in rheumatoid arthritis patients treated with tumor necrosis factor-alpha blockers: the GISEA study
    Luana Mancarella
    Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy
    J Rheumatol 34:1670-3. 2007
    ..To assess the prevalence of good clinical response and remission in rheumatoid arthritis (RA) patients with longstanding disease treated with anti-tumor necrosis factor-alpha (TNF-alpha) drugs at outpatient clinics...
  43. doi request reprint Light transmittance aggregometry induced by different concentrations of adenosine diphosphate to monitor clopidogrel therapy: a methodological study
    Rita Paniccia
    Department of Medical and Surgical Critical Care, Thrombosis Center, University of Florence, Florence, Italy
    Ther Drug Monit 33:94-8. 2011
    ..This suggests that a concentration of 10 ╬╝mol/L ADP may be considered adequate for the identification of RPR of patients on clopidogrel and should be preferred for standardization LTA...
  44. doi request reprint Registries in systemic sclerosis: a worldwide experience
    Felice Galluccio
    Department of Biomedicine, Division of Rheumatology AOUC, Denothe Centre, University of Florence, Villa Monna Tessa, Viale Pieraccini 18, 50139 Firenze, Italy
    Rheumatology (Oxford) 50:60-8. 2011
    ....
  45. doi request reprint Implantable cardioverter defibrillator prevents sudden cardiac death in systemic sclerosis
    Pasquale Bernardo
    Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
    J Rheumatol 38:1617-21. 2011
    ..We tested whether electrophysiologic studies and implantation of cardioverter defibrillators are recommended when ventricular arrhythmias are present...
  46. ncbi request reprint Accelerated atherosclerosis in autoimmune rheumatic diseases
    Yehuda Shoenfeld
    Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Circulation 112:3337-47. 2005
  47. ncbi request reprint The Pediatric Rheumatology European Society/American College of Rheumatology/European League against Rheumatism provisional classification criteria for juvenile systemic sclerosis
    Francesco Zulian
    Dipartimento di Pediatria, University of Padua, Padua, Italy
    Arthritis Rheum 57:203-12. 2007
    ..To develop criteria for the classification of systemic sclerosis (SSc) in children (juvenile SSc)...
  48. ncbi request reprint Activin, a grape seed-derived proanthocyanidin extract, reduces plasma levels of oxidative stress and adhesion molecules (ICAM-1, VCAM-1 and E-selectin) in systemic sclerosis
    Reni Kalin
    Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington 06030 2110, USA
    Free Radic Res 36:819-25. 2002
    ..The results of this study demonstrated that Activin could reduce the inflammatory response and the oxidative stress developed in SSc patients...
  49. ncbi request reprint Interstitial lung disease in systemic sclerosis
    Predrag Ostojic
    Institute of Rheumatology, University of Belgrade, Belgrade, Serbia
    Lung 185:211-20. 2007
    ..Cyclophosphamide seems to be relatively effective to treat ILD in the earliest phase, but the effects of other immunosuppressive drugs on the lungs are less convincing...
  50. ncbi request reprint Early atherosclerosis and autoantibodies to heat-shock proteins and oxidized LDL in systemic sclerosis
    Yaniv Sherer
    Department of Medicine B, Center of Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel
    Ann N Y Acad Sci 1108:259-67. 2007
    ..Age rather than other clinical parameters is associated with early atherosclerotic changes in SSc. Autoantibodies to oxLDL, HSP-60, and HSP-65 are not elevated in SSc and there is only a borderline association with carotid artery IMT...
  51. ncbi request reprint Anti-inflammatory: new trends in the treatment of the patient with systemic sclerosis
    Gabriele Valentini
    Second University of Naples, Rheumatology Unit, Via Pansini 5, 80131 Napoli, Italy
    Expert Opin Emerg Drugs 13:227-36. 2008
    ..The treatment of systemic sclerosis is a difficult challenge because of the present lack of drugs definitely proven to alter the overall course of the disease...