D Centonze

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi request reprint Cocaine and amphetamine depress striatal GABAergic synaptic transmission through D2 dopamine receptors
    Diego Centonze
    Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata and Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropsychopharmacology 26:164-75. 2002
  2. ncbi request reprint Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism
    Mauro Maccarrone
    Dipartimento di Medicina Sperimentale e Scienze Biochimiche and Dipartimento di Neuroscienze, Universita degli Studi di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    J Neurochem 85:1018-25. 2003
  3. ncbi request reprint A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and IRCCS Fondazione Santa Lucia, Rome, Italy
    Neuropsychopharmacology 29:1488-97. 2004
  4. pmc Patient adherence to and tolerability of self-administered interferon β-1a using an electronic autoinjection device: a multicentre, open-label, phase IV study
    Alessandra Lugaresi
    Department of Neuroscience and Imaging, University G, D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    BMC Neurol 12:7. 2012
  5. doi request reprint Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis
    Diego Centonze
    Neurologic Clinic, Department of Neuroscience, Tor Vergata University, 00133 Rome, Italy
    J Neurosci 29:3442-52. 2009
  6. ncbi request reprint Effects of motor cortex rTMS on lower urinary tract dysfunction in multiple sclerosis
    D Centonze
    Dipartimento di Neuroscienze, Clinica Neurologica, Universita Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy
    Mult Scler 13:269-71. 2007
  7. ncbi request reprint Subthalamic nucleus lesion reverses motor abnormalities and striatal glutamatergic overactivity in experimental parkinsonism
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 133:831-40. 2005
  8. ncbi request reprint Synaptic plasticity during recovery from permanent occlusion of the middle cerebral artery
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Neurobiol Dis 27:44-53. 2007
  9. ncbi request reprint The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Brain 130:2543-53. 2007
  10. ncbi request reprint Deficits of glutamate transmission in the striatum of experimental hemiballism
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 143:213-21. 2006

Detail Information

Publications128 found, 100 shown here

  1. ncbi request reprint Cocaine and amphetamine depress striatal GABAergic synaptic transmission through D2 dopamine receptors
    Diego Centonze
    Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata and Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropsychopharmacology 26:164-75. 2002
    ..The modulation of GABAergic synaptic transmission in the striatum might underlie some motor and cognitive effects of psychostimulants in mammalians...
  2. ncbi request reprint Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism
    Mauro Maccarrone
    Dipartimento di Medicina Sperimentale e Scienze Biochimiche and Dipartimento di Neuroscienze, Universita degli Studi di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    J Neurochem 85:1018-25. 2003
    ....
  3. ncbi request reprint A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and IRCCS Fondazione Santa Lucia, Rome, Italy
    Neuropsychopharmacology 29:1488-97. 2004
    ..Understanding the molecular and physiological effects of drugs of abuse in the brain is essential for the development of effective strategies against addiction...
  4. pmc Patient adherence to and tolerability of self-administered interferon β-1a using an electronic autoinjection device: a multicentre, open-label, phase IV study
    Alessandra Lugaresi
    Department of Neuroscience and Imaging, University G, D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    BMC Neurol 12:7. 2012
    ..We sought to assess short-term adherence to, and tolerability of, interferon (IFN) β-1a administered via electronic autoinjection device in patients with relapsing-remitting multiple sclerosis (RRMS)...
  5. doi request reprint Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis
    Diego Centonze
    Neurologic Clinic, Department of Neuroscience, Tor Vergata University, 00133 Rome, Italy
    J Neurosci 29:3442-52. 2009
    ..Our data establish a link between neuroinflammation and synaptic degeneration and calls for early neuroprotective therapies in chronic inflammatory diseases of the CNS...
  6. ncbi request reprint Effects of motor cortex rTMS on lower urinary tract dysfunction in multiple sclerosis
    D Centonze
    Dipartimento di Neuroscienze, Clinica Neurologica, Universita Tor Vergata, Rome, Italy and Fondazione Santa Lucia IRCCS, Rome, Italy
    Mult Scler 13:269-71. 2007
    ....
  7. ncbi request reprint Subthalamic nucleus lesion reverses motor abnormalities and striatal glutamatergic overactivity in experimental parkinsonism
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 133:831-40. 2005
    ..Since neither l-DOPA treatment nor STN lesion affected sEPSCs kinetic properties, the reversal of these abnormalities in striatal excitatory synaptic transmission can be attributable to the normalization of glutamate release...
  8. ncbi request reprint Synaptic plasticity during recovery from permanent occlusion of the middle cerebral artery
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Neurobiol Dis 27:44-53. 2007
    ..Our results provide a synaptic correlate of the long-lasting brain hyperexcitability mediating recovery described with noninvasive neurophysiological approaches...
  9. ncbi request reprint The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Brain 130:2543-53. 2007
    ..Our study suggests that targeting the endocannabinoid system might be useful for the treatment of MS...
  10. ncbi request reprint Deficits of glutamate transmission in the striatum of experimental hemiballism
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 143:213-21. 2006
    ....
  11. ncbi request reprint Mechanisms of disease: basic-research-driven investigations in humans--the case of hyperkinetic disorders
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Nat Clin Pract Neurol 3:572-80. 2007
    ..These findings could have implications for the treatment of hyperkinetic disorders in the clinic, and they illustrate how basic neuroscience can generate predictions to be tested in patients...
  12. doi request reprint Proposed chronic cerebrospinal venous insufficiency criteria do not predict multiple sclerosis risk or severity
    Diego Centonze
    Department of Neuroscience, University Hospital Tor Vergata, Rome, Italy
    Ann Neurol 70:51-8. 2011
    ..This information is particularly relevant, because uncontrolled surgical procedures are increasingly offered to MS patients to treat their venous stenoses...
  13. doi request reprint Genetic variants of the NMDA receptor influence cortical excitability and plasticity in humans
    Francesco Mori
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    J Neurophysiol 106:1637-43. 2011
    ....
  14. ncbi request reprint Abnormal striatal GABA transmission in the mouse model for the fragile X syndrome
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Biol Psychiatry 63:963-73. 2008
    ..Structural and functional neuroimaging studies suggest abnormal activity in the striatum of patients with the fragile X syndrome (FXS), the most common form of inherited mental retardation...
  15. doi request reprint Adaptations of glutamatergic synapses in the striatum contribute to recovery from cerebellar damage
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Eur J Neurosci 27:2188-96. 2008
    ....
  16. doi request reprint Early relapses after the first dose of natalizumab in active multiple sclerosis patients
    D Centonze
    Department of Neuroscience, Neurologic Clinics, Tor Vergata University, Rome, Italy
    Mult Scler 14:1137-8. 2008
    ..Natalizumab is prescribed in Italy in patients who experienced at least two clinical relapses during a 12-month therapy with other approved immunomodulatory agents...
  17. doi request reprint The link between inflammation, synaptic transmission and neurodegeneration in multiple sclerosis
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Cell Death Differ 17:1083-91. 2010
    ....
  18. doi request reprint Lack of effect of cannabis-based treatment on clinical and laboratory measures in multiple sclerosis
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neurol Sci 30:531-4. 2009
    ..This compound also failed to affect the synthesis and the degradation of the endocannabinoid anandamide, as well as the expression of both CB1 and CB2 cannabinoid receptors in various subpopulations of peripheral lymphocytes...
  19. ncbi request reprint Endocannabinoids limit metabotropic glutamate 5 receptor-mediated synaptic inhibition of striatal principal neurons
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Mol Cell Neurosci 35:302-10. 2007
    ..In conclusion, we have identified an mGlu-dependent mechanism of GABA transmission regulation of potential relevance for physiological neuronal activity...
  20. ncbi request reprint Chronic cocaine sensitizes striatal GABAergic synapses to the stimulation of cannabinoid CB1 receptors
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, Rome, Italy
    Eur J Neurosci 25:1631-40. 2007
    ..Our data support the concept that modulation of cannabinoid receptors might be useful against drug abuse...
  21. ncbi request reprint Removing pathogenic memories: a neurobiology of psychotherapy
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Mol Neurobiol 32:123-32. 2005
    ....
  22. ncbi request reprint CSF from MS patients can induce acute conduction block in the isolated optic nerve
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and Fondazione Santa Lucia, IRCCS, Rome, Italy
    Eur J Neurol 12:45-8. 2005
    ..The reversible blockade of ion channels by soluble substances might account, at least in part, for the transient symptoms often seen in MS patients...
  23. ncbi request reprint The Project for a Scientific Psychology (1895): a Freudian anticipation of LTP-memory connection theory
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Brain Res Brain Res Rev 46:310-4. 2004
    ..In the present article we aim at presenting Freudian theory on the functional organization of the nervous system developed in the Project, with particular respect to his ideas of the cellular bases of memory...
  24. ncbi request reprint Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striatum of R6/2 Huntington's disease mice
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Italy
    Biol Psychiatry 57:1583-9. 2005
    ..How this alteration impacts striatal synaptic transmission is unknown...
  25. ncbi request reprint Chronic cocaine prevents depotentiation at corticostriatal synapses
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Biol Psychiatry 60:436-43. 2006
    ..A pathology of habit forming systems might underlie these features of addiction...
  26. pmc Cortical hyperexcitability in post-traumatic stress disorder secondary to minor accidental head trauma: a neurophysiologic study
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Rome, Italy
    J Psychiatry Neurosci 30:127-32. 2005
    ..Our purpose was to determine the potential abnormality of motor cortex excitability in this pathologic condition...
  27. ncbi request reprint NR2B-containing NMDA receptors promote the neurotoxic effects of 3-nitropropionic acid but not of rotenone in the striatum
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, 00133 Rome, Italy
    Exp Neurol 202:470-9. 2006
    ....
  28. ncbi request reprint Repetitive transcranial magnetic stimulation of the motor cortex ameliorates spasticity in multiple sclerosis
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Rome, Italy
    Neurology 68:1045-50. 2007
    ..To investigate whether repetitive transcranial magnetic stimulation (rTMS) can modify spasticity...
  29. ncbi request reprint Long-term potentiation and memory processes in the psychological works of Sigmund Freud and in the formation of neuropsychiatric symptoms
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 130:559-65. 2005
    ..Freud's insights did not stop here, but went on to describe in an extremely precise manner the neural mechanisms of memory formation almost a century before the description of long-term synaptic potentiation...
  30. ncbi request reprint Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, , Rome 00133, Italy
    J Neurosci 21:5110-20. 2001
    ..Thus 3-NP-LTP might play a key role in the regional and cell type-specific neuronal death observed in HD...
  31. ncbi request reprint An abnormal striatal synaptic plasticity may account for the selective neuronal vulnerability in Huntington's disease
    D Centonze
    Neurosciences Department, University of Rome Tor Vergata, Rome, Italy
    Neurol Sci 22:61-2. 2001
    ..This pathological form of corticostriatal synaptic plasticity might play a key role in the regional and cell-type specific neuronal death observed in HD...
  32. doi request reprint Transient receptor potential vanilloid 1 channels control acetylcholine/2-arachidonoylglicerol coupling in the striatum
    A Musella
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Neuroscience 167:864-71. 2010
    ..Pharmacological interventions targeting AEA metabolism and TRPV1 channels might be considered alternative therapeutic routes in disorders of striatal cholinergic or endocannabinoid neurotransmission...
  33. ncbi request reprint Stimulation of nitric oxide-cGMP pathway excites striatal cholinergic interneurons via protein kinase G activation
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, , 00133 Rome, Italy
    J Neurosci 21:1393-400. 2001
    ..The characterization of the cellular mechanisms involved in the regulation of striatal interneuron activity is a key step for the understanding of the role of these cells in striatal microcircuitry...
  34. ncbi request reprint Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons
    A Pisani
    Clinica Neurologica, Dipartmento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuroscience 106:579-87. 2001
    ....
  35. ncbi request reprint A synaptic mechanism underlying the behavioral abnormalities induced by manganese intoxication
    P Calabresi
    Clinica Neurologica, Dipartemente Neuroscienze, Universita' di Roma Tor Vergata, Via di Tor Vergata 135, Rome, 00133, Italy
    Neurobiol Dis 8:419-32. 2001
    ....
  36. ncbi request reprint Corticostriatal LTP requires combined mGluR1 and mGluR5 activation
    P Gubellini
    Istituto di Neurobiologia e Medicina Molecolare, CNR, Rome, Italy
    Neuropharmacology 44:8-16. 2003
    ....
  37. ncbi request reprint Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons
    P Bonsi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, C E R C, Rome, Italy
    Neuropharmacology 49:104-13. 2005
    ..Together, these data suggest that mGluR5 modulates mGluR1 activity to shape cell excitability...
  38. ncbi request reprint Endogenous ACh enhances striatal NMDA-responses via M1-like muscarinic receptors and PKC activation
    P Calabresi
    Clinica Neurologica, Dip Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Eur J Neurosci 10:2887-95. 1998
    ..Our data show that endogenous striatal ACh exerts a positive modulatory action on NMDA responses via M1-like muscarinic receptors and PKC activation...
  39. ncbi request reprint Electrophysiology of sipatrigine: a lamotrigine derivative exhibiting neuroprotective effects
    P Calabresi
    Clinica Neurologica, Universita Tor Vergata, Rome, 00133, Italy
    Exp Neurol 162:171-9. 2000
    ....
  40. pmc An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons
    P Calabresi
    Dip Sanità, Universita di Roma Tor Vergata, Rome, Italy
    Br J Pharmacol 126:689-96. 1999
    ....
  41. ncbi request reprint Differential contribution of dopamine D2S and D2L receptors in the modulation of glutamate and GABA transmission in the striatum
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 129:157-66. 2004
    ..Understanding the physiological roles of DA D2 receptors in the striatum is essential for the treatment of several neuropsychiatric conditions, such as Parkinson's disease, Tourette's syndrome, schizophrenia, and drug addiction...
  42. ncbi request reprint Lamotrigine and remacemide protect striatal neurons against in vitro ischemia: an electrophysiological study
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Exp Neurol 182:461-9. 2003
    ..A combined use of lamotrigine and remacemide could be employed in clinical trials to enhance neuroprotection in neurological disorders involving an abnormal striatal glutamatergic transmission...
  43. pmc Muscarinic IPSPs in rat striatal cholinergic interneurones
    P Calabresi
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    J Physiol 510:421-7. 1998
    ..6. The findings demonstrate that muscarinic IPSPs occur in the central nervous system. The IPSP may mediate an 'autoinhibition' of striatal cholinergic neurone activity...
  44. ncbi request reprint Activation of metabotropic glutamate receptor subtype 1/protein kinase C/mitogen-activated protein kinase pathway is required for postischemic long-term potentiation in the striatum
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Roma, Italy
    Mol Pharmacol 60:808-15. 2001
    ....
  45. ncbi request reprint Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Rome, Italy
    J Neurosci 20:8443-51. 2000
    ..These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations...
  46. ncbi request reprint Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuropharmacology 40:460-3. 2001
    ..The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons...
  47. ncbi request reprint Tissue plasminogen activator controls multiple forms of synaptic plasticity and memory
    P Calabresi
    Clinica Neurologica, Dip Neuroscienze, Universita di Tor Vergata, Via di Tor Vergata 135, Rome 00133, Italy
    Eur J Neurosci 12:1002-12. 2000
    ..These data indicate that t-PA plays a critical role in the formation of various forms of synaptic plasticity and memory...
  48. ncbi request reprint Early ionic and membrane potential changes caused by the pesticide rotenone in striatal cholinergic interneurons
    P Bonsi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Fondazione Santa Lucia, IRCCS, 00133 Rome, Italy
    Exp Neurol 185:169-81. 2004
    ..In turn, the hyperpolarizing response might be generated both by the opening of ATP-sensitive K+ channels and by Na+-activated K+ conductances. The increase in [Ca2+]i occurs lately and does not seem to influence the early events...
  49. ncbi request reprint Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, , Rome, Italy
    Brain 124:1855-65. 2001
    ..The early depression of GABA-mediated synaptic transmission might play a role in the development of irreversible neuronal injury in the course of brain ischaemia...
  50. ncbi request reprint Activation of D2-like dopamine receptors reduces synaptic inputs to striatal cholinergic interneurons
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 20:RC69. 2000
    ....
  51. ncbi request reprint Dopaminergic control of synaptic plasticity in the dorsal striatum
    D Centonze
    Clinica Neurologica, Dip. Neuroscienze, , Via di Tor Vergata 135, Rome 00133, Italy
    Eur J Neurosci 13:1071-7. 2001
    ..These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations...
  52. ncbi request reprint Is pharmacological neuroprotection dependent on reduced glutamate release?
    P Calabresi
    Clinica Neurologica, Dipartimiento Neuroscienze, Universita di Tor Vergata, Rome, Italy
    Stroke 31:766-72; discussion 773. 2000
    ....
  53. pmc Oral fingolimod rescues the functional deficits of synapses in experimental autoimmune encephalomyelitis
    S Rossi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Br J Pharmacol 165:861-9. 2012
    ..LINKED ARTICLE This article is commented on by Gillingwater, pp. 858-860 of this issue. To view this commentary visit http://dx.doi.org/10.1111/j.1476-5381.2011.01612.x...
  54. ncbi request reprint Impaired excitatory transmission in the striatum of rats chronically intoxicated with manganese
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita' Tor Vergata, Via di Tor Vergata 135, Rome, 00133, Italy
    Exp Neurol 172:469-76. 2001
    ..It is concluded, therefore, that hyperactivity of corticostriatal neurons, rather than increased postsynaptic sensitivity to glutamate, accounts for the abnormal excitation of striatal neurons in the course of Mn intoxication...
  55. ncbi request reprint Activation of beta1-adrenoceptors excites striatal cholinergic interneurons through a cAMP-dependent, protein kinase-independent pathway
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    J Neurosci 23:5272-82. 2003
    ..We conclude that NA depolarizes striatal cholinergic interneurons via beta1-adrenoceptor activation, through a cAMP-dependent but PKA-independent mechanism...
  56. ncbi request reprint Modulation of gene expression following long-term synaptic depression in the striatum
    M Napolitano
    Department of Experimental Medicine and Pathology, University La Sapienza, Viale Regina Elena 324, 00161, Rome, Italy
    Brain Res Mol Brain Res 72:89-96. 1999
    ..Our data suggest that a complex pattern of genes acting at presynaptic level and extracellularly may be involved in LTD-associated synaptic remodeling...
  57. ncbi request reprint Cell-type specificity of mGluR activation in striatal neuronal subtypes
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Amino Acids 19:119-29. 2000
    ....
  58. ncbi request reprint Blockade of M2-like muscarinic receptors enhances long-term potentiation at corticostriatal synapses
    P Calabresi
    Clinica Neurologica, Dip Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Eur J Neurosci 10:3020-3. 1998
    ....
  59. ncbi request reprint Endogenous dopamine amplifies ischemic long-term potentiation via D1 receptors
    Emilia Saulle
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, and IRCCS Fondazione Santa Lucia, Rome, Italy
    Stroke 33:2978-84. 2002
    ..In an attempt to clarify how dopamine takes part in ischemia-induced neuronal damage, we performed in vitro electrophysiological recordings from neurons of the nucleus striatum...
  60. doi request reprint Effect of glatiramer acetate on disease reactivation in MS patients discontinuing natalizumab
    S Rossi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Eur J Neurol 20:87-94. 2013
    ..Multiple sclerosis (MS) patients discontinuing natalizumab are at risk of rebound of disease activity...
  61. ncbi request reprint Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors
    P Calabresi
    Clinica Neurologica, Universita di Roma Tor Vergata, Dipartimento Sanita, 00173 Rome, Italy
    J Neurosci 17:4536-44. 1997
    ..It also shows that an imbalance between D2R and NMDA receptor activity induces altered synaptic plasticity at corticostriatal synapses. This abnormal synaptic plasticity might cause the movement disorders observed in Parkinson's disease...
  62. ncbi request reprint Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita degli Studi di Roma, Italy
    Neuropharmacology 38:323-6. 1999
    ....
  63. doi request reprint Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum
    Valentina De Chiara
    Clinica Neurologica and Clinica Psichiatrica, Dipartimento di Neuroscienze, Universita Tor Vergata, 00133 Rome, Italy
    J Neurosci 30:8127-37. 2010
    ..The present study identifies a novel mechanism of CB(1)R regulation mediated by BDNF and cholesterol metabolism and provides some evidence that DA D(2)R-dependent modulation of striatal CB(1)R activity is mediated by this neurotrophin...
  64. ncbi request reprint Synaptic transmission in the striatum: from plasticity to neurodegeneration
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata 135, 00133, Rome, Italy
    Prog Neurobiol 61:231-65. 2000
    ..These ionic mechanisms might partially explain the selective neuronal vulnerability observed in the striatum during global ischemia and Huntington's disease...
  65. ncbi request reprint Selective involvement of mGlu1 receptors in corticostriatal LTD
    P Gubellini
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via di Tor Vergata 135, 00133, Rome, Italy
    Neuropharmacology 40:839-46. 2001
    ..mGluR1-mediated control of this form of synaptic plasticity may play a role in the modulatory effect exerted by mGluRs in the basal ganglia-related motor activity...
  66. ncbi request reprint Targeting striatal cholinergic interneurons in Parkinson's disease: focus on metabotropic glutamate receptors
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuropharmacology 45:45-56. 2003
    ..The potential relevance of these findings in the control of motor function and in the treatment of PD will be discussed...
  67. doi request reprint Effects of intermittent theta burst stimulation on spasticity in patients with multiple sclerosis
    F Mori
    Dipartimento di Neuroscienze, Clinica Neurologica, Universita Tor Vergata, Rome, Italy
    Eur J Neurol 17:295-300. 2010
    ..Our aim was to evaluate whether a recently developed repetitive transcranial magnetic stimulation protocol, the intermittent theta burst stimulation (iTBS) is effective in modulating lower limb spasticity in MS patients...
  68. ncbi request reprint Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, 00133 Rome, Italy
    J Neurosci 23:8506-12. 2003
    ....
  69. ncbi request reprint Neuronal vulnerability following inhibition of mitochondrial complex II: a possible ionic mechanism for Huntington's disease
    Emilia Saulle
    Clinica Neurologica, Dipartimento di Medicina Clinica e Sperimentale, Universita di Ferrara, Ferrara, Italy
    Mol Cell Neurosci 25:9-20. 2004
    ..Conversely, the hyperpolarization did not significantly differ from the one recorded in WT mice. The diverse membrane changes induced by SD inhibition may contribute to the cell-type-specific neuronal death in HD...
  70. doi request reprint Potential role of IL-13 in neuroprotection and cortical excitability regulation in multiple sclerosis
    S Rossi
    Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Mult Scler 17:1301-12. 2011
    ..Inflammation triggers secondary neurodegeneration in multiple sclerosis (MS)...
  71. ncbi request reprint Ionic mechanisms underlying differential vulnerability to ischemia in striatal neurons
    D Centonze
    IRCCS Ospedale S. Lucia, Rome, Italy
    Prog Neurobiol 63:687-96. 2001
    ..The understanding of the ionic mechanisms underlying the differential membrane responses to ischemia represents the basis for the development of rational neuroprotective treatments during acute cerebrovascular insults...
  72. ncbi request reprint Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, 00133 Rome, Italy
    J Neurosci 23:6245-54. 2003
    ....
  73. ncbi request reprint Deficits of glutamate transmission in the striatum of toxic and genetic models of Huntington's disease
    Silvia Rossi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neurosci Lett 410:6-10. 2006
    ..In both models, we found a significant down-regulation of glutamate transmission, suggesting that reduced synaptic excitation of the input structure of the basal ganglia represents a physiological correlate of HD...
  74. pmc Voluntary exercise and sucrose consumption enhance cannabinoid CB1 receptor sensitivity in the striatum
    Valentina De Chiara
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Neuropsychopharmacology 35:374-87. 2010
    ....
  75. ncbi request reprint Chronic haloperidol promotes corticostriatal long-term potentiation by targeting dopamine D2L receptors
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, 00133 Rome, Italy
    J Neurosci 24:8214-22. 2004
    ..The identification of the cellular, molecular, and receptor mechanisms involved in the action of haloperidol in the brain is essential to understand how antipsychotic agents exert their beneficial and side effects...
  76. ncbi request reprint Activation of dopamine D1-like receptors excites LTS interneurons of the striatum
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via di Tor Vergata, 135, 00133 Rome, Italy
    Eur J Neurosci 15:2049-52. 2002
    ..In addition, this pharmacological effect was mimicked by D1- but not D2-like DA receptor agonists, implying the selective involvement of D1-like receptors in this action...
  77. ncbi request reprint The brain cytoplasmic RNA BC1 regulates dopamine D2 receptor-mediated transmission in the striatum
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    J Neurosci 27:8885-92. 2007
    ....
  78. doi request reprint Exercise attenuates the clinical, synaptic and dendritic abnormalities of experimental autoimmune encephalomyelitis
    Silvia Rossi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neurobiol Dis 36:51-9. 2009
    ..Our work suggests that life style and experiences can impact the clinical course of inflammatory neurodegenerative diseases by affecting their synaptic bases...
  79. ncbi request reprint Dopamine excites fast-spiking interneurons in the striatum
    Enrico Bracci
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome 00133, Italy
    J Neurophysiol 87:2190-4. 2002
    ..These results show that endogenous dopamine exerts a dual excitatory action on FS interneurons, by directly depolarizing them (through D1-like receptors) and by reducing their synaptic inhibition (through presynaptic D2-like receptors)...
  80. doi request reprint Abnormal sensitivity of cannabinoid CB1 receptors in the striatum of mice with experimental amyotrophic lateral sclerosis
    Silvia Rossi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Amyotroph Lateral Scler 11:83-90. 2010
    ..In conclusion, our data identify possible physiological correlates of striatal dysfunction in ALS mice, and suggest that cannabinoid CB1 receptors might be potential therapeutic targets for this dramatic disease...
  81. ncbi request reprint rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease
    G Koch
    Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neurology 65:623-5. 2005
    ..rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase...
  82. doi request reprint TRPV1 channels facilitate glutamate transmission in the striatum
    Alessandra Musella
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Mol Cell Neurosci 40:89-97. 2009
    ..TRPV1-mediated regulation of excitatory transmission in the striatum might be important for the final output to other basal ganglia structures, and might play a role in several physiological and pathological processes...
  83. ncbi request reprint NR2B subunit exerts a critical role in postischemic synaptic plasticity
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, Rome, Italy
    Stroke 37:1895-901. 2006
    ..We characterized the differential effect of the NR2B subunit antagonist ifenprodil in the induction of activity-dependent long-term potentiation (LTP) and of postischemic LTP as well as in the neuronal damage induced by focal ischemia...
  84. ncbi request reprint Abnormal Ca2+-calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 24:5283-91. 2004
    ..Normalization of CaMKII activity may be an important underlying mechanism of the therapeutic action of L-DOPA in PD...
  85. ncbi request reprint Cerebellar control of cortico-striatal LTD
    Silvia Rossi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Restor Neurol Neurosci 26:475-80. 2008
    ..Recent anatomical studies showed the presence of cerebellar and basal ganglia connections. It is thus conceivable that the cerebellum may influence the striatal synaptic transmission in general, and synaptic plasticity in particular...
  86. doi request reprint Improvement of hand dexterity following motor cortex rTMS in multiple sclerosis patients with cerebellar impairment
    G Koch
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Mult Scler 14:995-8. 2008
    ..rTMS of the motor cortex may be a useful approach to treat cerebellar impairment in MS patients...
  87. ncbi request reprint Inhibition of mitochondrial complex II alters striatal expression of genes involved in glutamatergic and dopaminergic signaling: possible implications for Huntington's disease
    Maddalena Napolitano
    Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Rome, Italy
    Neurobiol Dis 15:407-14. 2004
    ..Our data provide new information about the molecular events possibly underlying neurodegeneration induced by this mitochondrial toxin...
  88. doi request reprint Chronic psychoemotional stress impairs cannabinoid-receptor-mediated control of GABA transmission in the striatum
    Silvia Rossi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, 00133 Rome, Italy
    J Neurosci 28:7284-92. 2008
    ..Targeting cannabinoid CB(1) receptors or endocannabinoid metabolism might be a valuable option to treat stress-associated neuropsychiatric conditions...
  89. ncbi request reprint Dopamine, acetylcholine and nitric oxide systems interact to induce corticostriatal synaptic plasticity
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Rev Neurosci 14:207-16. 2003
    ....
  90. ncbi request reprint Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, I R C C S Fondazione Santa Lucia, Italy
    Brain 125:2635-45. 2002
    ..We suggest that an enhanced sensitivity of pre-synaptic inhibitory mGlu2/3 receptors might represent an adaptive change triggered by dopaminergic denervation, which can be reversed by L-DOPA treatment...
  91. doi request reprint Connectivity between posterior parietal cortex and ipsilateral motor cortex is altered in schizophrenia
    Giacomo Koch
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Biol Psychiatry 64:815-9. 2008
    ..Recent advances have highlighted the hypothesis of schizophrenia as a disorder causing defective connectivity among distinct cortical regions. Neurophysiological evidence supporting this hypothesis, however, is still lacking...
  92. doi request reprint Cannabis-based treatment induces polarity-reversing plasticity assessed by theta burst stimulation in humans
    Giacomo Koch
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Brain Stimul 2:229-33. 2009
    ..Both long-term potentiation (LTP) and depression (LTD) phenomena can be induced in the human motor cortex by transcranial magnetic theta burst stimulation (TBS)...
  93. ncbi request reprint Tissue plasminogen activator is required for striatal post-ischemic synaptic potentiation
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Neuroreport 13:115-8. 2002
    ..The absence of striatal post-ischemic pote ntiat ion observed in tPA-lacking mice may account for the significant neuroprotection observed in these animals after the occlusion of middle cerebral artery...
  94. ncbi request reprint Tissue plasminogen activator is required for corticostriatal long-term potentiation
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur J Neurosci 16:713-21. 2002
    ....
  95. ncbi request reprint Experimental parkinsonism modulates multiple genes involved in the transduction of dopaminergic signals in the striatum
    Maddalena Napolitano
    Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Rome, Italy
    Neurobiol Dis 10:387-95. 2002
    ....
  96. ncbi request reprint Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Nat Neurosci 6:501-6. 2003
    ..These results indicate that abnormal information storage in corticostriatal synapses is linked with the development of L-DOPA-induced dyskinesia...
  97. ncbi request reprint Cellular factors controlling neuronal vulnerability in the brain: a lesson from the striatum
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, and the IRCCS, S Lucia, Rome, Italy
    Neurology 55:1249-55. 2000
    ..Specific molecules able to target these cellular factors might be employed as therapeutic agents during acute and chronic neurologic disorders affecting this brain area...
  98. doi request reprint Risk of acute promyelocytic leukemia in multiple sclerosis: coding variants of DNA repair genes
    S K Hasan
    Department of Biopathology, University Tor Vergata, Via Montpellier 1, 00133, Rome, Italy
    Neurology 76:1059-65. 2011
    ..We analyzed polymorphic variants of DNA repair and detoxification genes in patients with multiple sclerosis (MS) who developed secondary acute promyelocytic leukemia (sAPL), in most cases after treatment with mitoxantrone (MTZ)...
  99. ncbi request reprint Therapeutic doses of L-dopa reverse hypersensitivity of corticostriatal D2-dopamine receptors and glutamatergic overactivity in experimental parkinsonism
    Barbara Picconi
    Dipartimento di Neuroscienze, Clinica Neurologica, Universita di Roma Tor Vergata, Rome, Italy
    Brain 127:1661-9. 2004
    ....
  100. ncbi request reprint Pathological synaptic plasticity in the striatum: implications for Parkinson's disease
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata and Fondazione Santa Lucia, I R C C S, Via di Tor Vergata 135, Roma, Italy
    Neurotoxicology 26:779-83. 2005
    ..The potential relevance of these findings in the control of motor function and in the pathogenesis both of Parkinson's disease and l-dopa-induced motor complications will be discussed...
  101. doi request reprint Abnormal parieto-motor connectivity in Tuberous Sclerosis Complex
    Luigi D'Argenzio
    Paediatric Neurology and Psychiatry Unit, Neuroscience Department, Tor Vergata University, Rome, Italy
    Epilepsy Res 87:102-5. 2009
    ..Such altered connectivity might play a role in TSC epileptic phenotype...