Francesco Cecconi

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. pmc The role of autophagy in mammalian development: cell makeover rather than cell death
    Francesco Cecconi
    Dulbecco Telethon Institute at the Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Dev Cell 15:344-57. 2008
  2. pmc Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer's disease
    Francesca Fanelli
    Department of Biology LIME, University Roma Tre, Viale Marconi 446, Rome 00146, Italy
    Mol Neurodegener 8:8. 2013
  3. doi request reprint c-Cbl targets active Src for autophagy
    Francesco Cecconi
    Dulbecco Telethon Institute, Department of Biology, University of Tor Vergata, 00133 Rome, Italy
    Nat Cell Biol 14:48-9. 2012
  4. pmc The apoptosome: emerging insights and new potential targets for drug design
    Marcello D'Amelio
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143, Rome, Italy
    Pharm Res 25:740-51. 2008
  5. ncbi request reprint Apaf1 in developmental apoptosis and cancer: how many ways to die?
    F Cecconi
    Department of Biology, University of Rome Tor Vergata, Italy
    Cell Mol Life Sci 58:1688-97. 2001
  6. doi request reprint mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
    Francesca Nazio
    Dulbecco Telethon Institute at the Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Nat Cell Biol 15:406-16. 2013
  7. pmc Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
    Flavie Strappazzon
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, Rome, Italy
    EMBO J 30:1195-208. 2011
  8. doi request reprint Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage
    Maria Teresa Viscomi
    IRCCS S Lucia Foundation, Rome, Italy
    Autophagy 8:222-35. 2012
  9. doi request reprint Apaf1 plays a pro-survival role by regulating centrosome morphology and function
    Elisabetta Ferraro
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143, Rome, Italy
    J Cell Sci 124:3450-63. 2011
  10. pmc Apoptosome-deficient cells lose cytochrome c through proteasomal degradation but survive by autophagy-dependent glycolysis
    Elisabetta Ferraro
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143, Rome, Italy
    Mol Biol Cell 19:3576-88. 2008

Detail Information

Publications45

  1. pmc The role of autophagy in mammalian development: cell makeover rather than cell death
    Francesco Cecconi
    Dulbecco Telethon Institute at the Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Dev Cell 15:344-57. 2008
    ..Thus, autophagy is a process of cytosolic "renovation," crucial in cell fate decisions...
  2. pmc Age-dependent roles of peroxisomes in the hippocampus of a transgenic mouse model of Alzheimer's disease
    Francesca Fanelli
    Department of Biology LIME, University Roma Tre, Viale Marconi 446, Rome 00146, Italy
    Mol Neurodegener 8:8. 2013
    ..Several peroxisome-related markers in transgenic and wild-type hippocampal formation were comparatively studied, by a combined molecular/immunohistochemical/ultrastructural approach...
  3. doi request reprint c-Cbl targets active Src for autophagy
    Francesco Cecconi
    Dulbecco Telethon Institute, Department of Biology, University of Tor Vergata, 00133 Rome, Italy
    Nat Cell Biol 14:48-9. 2012
    ..Autophagosomes are now shown to entrap and promote degradation of the active tyrosine kinase Src, enabling tumour cell survival. The E3 ubiquitin ligase c-Cbl acts as an autophagosome cargo receptor for Src...
  4. pmc The apoptosome: emerging insights and new potential targets for drug design
    Marcello D'Amelio
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143, Rome, Italy
    Pharm Res 25:740-51. 2008
    ..Here we review recent progress in apoptosis-based pharmacological therapies and, in particular, we point out a possible role of the apoptosome as an emerging and promising pharmacological target...
  5. ncbi request reprint Apaf1 in developmental apoptosis and cancer: how many ways to die?
    F Cecconi
    Department of Biology, University of Rome Tor Vergata, Italy
    Cell Mol Life Sci 58:1688-97. 2001
    ..This review has a double aim: the analysis of the alternatives taken by the embryo to bring into the suicidal program different cells at different stages, and the relevance of APAF1 in the onset and progression of cancer...
  6. doi request reprint mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6
    Francesca Nazio
    Dulbecco Telethon Institute at the Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Nat Cell Biol 15:406-16. 2013
    ..As ULK1 has been shown to activate AMBRA1 by phosphorylation, the proposed pathway may act as a positive regulation loop, which may be targeted in human disorders linked to impaired autophagy...
  7. pmc Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
    Flavie Strappazzon
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, Rome, Italy
    EMBO J 30:1195-208. 2011
    ..Thus, a dynamic interaction exists between AMBRA1 and BCL-2 at the mitochondria that could regulate both BECLIN 1-dependent autophagy and apoptosis...
  8. doi request reprint Stimulation of autophagy by rapamycin protects neurons from remote degeneration after acute focal brain damage
    Maria Teresa Viscomi
    IRCCS S Lucia Foundation, Rome, Italy
    Autophagy 8:222-35. 2012
    ..These findings have therapeutic significance, demonstrating the potential of pro-autophagy treatments for acute brain pathologies, such as stroke and brain trauma...
  9. doi request reprint Apaf1 plays a pro-survival role by regulating centrosome morphology and function
    Elisabetta Ferraro
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143, Rome, Italy
    J Cell Sci 124:3450-63. 2011
    ..Therefore, Apaf1 might also be considered a pro-survival molecule, whose absence impairs cell performance and causes a higher responsiveness to stressful conditions...
  10. pmc Apoptosome-deficient cells lose cytochrome c through proteasomal degradation but survive by autophagy-dependent glycolysis
    Elisabetta Ferraro
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, 00143, Rome, Italy
    Mol Biol Cell 19:3576-88. 2008
    ..Unraveling this issue could be highly relevant for pharmacological intervention and for therapies based on neural stem cell transfer in the treatment of neurological disorders...
  11. ncbi request reprint A novel role for autophagy in neurodevelopment
    Francesco Cecconi
    Dulbecco Telethon Institute at the Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Autophagy 3:506-8. 2007
    ..In this article, we review our findings in the contexts of autophagy and neurodevelopment and consider some of the issues raised...
  12. ncbi request reprint Endoplasmic reticulum stress induces apoptosis by an apoptosome-dependent but caspase 12-independent mechanism
    Federica Di Sano
    Department of Biology, University of Tor Vergata
    J Biol Chem 281:2693-700. 2006
    ..We also demonstrate that caspase 12, a protease until now believed to play a central role in the initiation of ER stress-induced cell death in the mouse system, is dispensable for the mitochondrial pathway of death to take place...
  13. doi request reprint Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease
    Marcello D'Amelio
    Dulbecco Telethon Institute at the Laboratory of Molecular Neuroembryology, Istituto di Ricerca e Cura a Carattere Scientifico IRCCS Fondazione Santa Lucia, Rome, Italy
    Nat Neurosci 14:69-76. 2011
    ..These findings indicate that caspase-3 is a potential target for pharmacological therapy during early disease stages...
  14. ncbi request reprint Unleashing the Ambra1-Beclin 1 complex from dynein chains: Ulk1 sets Ambra1 free to induce autophagy
    Gian Maria Fimia
    National Institute for Infectious Diseases IRCCS L Spallanzani, Rome, Italy
    Autophagy 7:115-7. 2011
    ..Ambra1 is therefore not only a cofactor of Beclin 1 in favoring its kinase-associated activity, but also a crucial upstream regulator of autophagy initiation...
  15. pmc The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
    Sabrina Di Bartolomeo
    Dulbecco Telethon Institute, University of Rome Tor Vergata, 00133 Rome, Italy
    J Cell Biol 191:155-68. 2010
    ..Moreover, our results demonstrate that in addition to a function for microtubules in mediating autophagosome transport, there is a strict and regulatory relationship between cytoskeleton dynamics and autophagosome formation...
  16. ncbi request reprint Non-apoptotic roles for death-related molecules: when mitochondria chose cell fate
    Flavie Strappazzon
    IRCCS Fondazione Santa Lucia, 00143 Rome, Italy
    Exp Cell Res 318:1309-15. 2012
    ..Turning the double-edged swords of death molecules into plougshares may turn out to be strategically crucial in molecular oncology...
  17. ncbi request reprint Expanding roles of programmed cell death in mammalian neurodevelopment
    Daniela De Zio
    Dulbecco Telethon Institute, Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Semin Cell Dev Biol 16:281-94. 2005
    ..We also discuss the impact of studying programmed cell death in development in order to better understand the basis of several human diseases and embryonic defects of the nervous system...
  18. pmc A New Transgenic Mouse Model for Studying the Neurotoxicity of Spermine Oxidase Dosage in the Response to Excitotoxic Injury
    Manuela Cervelli
    Dipartimento di Biologia, Universit Roma Tre, Rome, Italy
    PLoS ONE 8:e64810. 2013
    ..These results provide novel evidences of the complex and critical functions carried out by spermine oxidase and spermine in the mammalian brain...
  19. doi request reprint Aβ toxicity in Alzheimer's disease
    Virve Cavallucci
    Department of Experimental Neurosciences, IRCCS Fondazione Santa Lucia, 00143 Rome, Italy
    Mol Neurobiol 45:366-78. 2012
    ..The knowledge of the exact mechanisms by which Aβ peptide impairs neuronal function will help us to design new pharmacological tools for preventing AD neurodegeneration...
  20. doi request reprint Analysis of neuronal cell death in mammals
    Marcello D'Amelio
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, Rome, Italy
    Methods Enzymol 446:259-76. 2008
    ..The goal of this chapter is to provide readers with a scientific guide to proven methods that highlight the current strategies for detecting apoptosis in the nervous system...
  21. ncbi request reprint Apaf1 mediates apoptosis and mitochondrial damage induced by mutant human SOD1s typical of familial amyotrophic lateral sclerosis
    Mauro Cozzolino
    Lab di Neurochimica, Centro di Neurobiologia Sperimentale Mondino Tor Vergata Santa Lucia, Rome, Italy
    Neurobiol Dis 21:69-79. 2006
    ..This death pathway may be crucial also for the pathogenesis of the sporadic form of the disease, where markers of increased oxidative stress and mitochondria damage have been found...
  22. ncbi request reprint Analysis of apoptosome dysregulation in pancreatic cancer and of its role in chemoresistance
    Marco Corvaro
    Dulbecco Telethon Institute, Department of Biology, University of Tor Vergata, Via della Ricerca Scientifica, Rome 00133, Italy
    Cancer Biol Ther 6:209-17. 2007
    ..In addition, we restored APAF1 and Caspase-9 dosage in Panc-1 cells, where the apoptosome is downregulated, by overexpressing the murine cDNA of the two molecules, and we improved the death response to chemotherapeutic agents...
  23. ncbi request reprint Apaf1-dependent programmed cell death is required for inner ear morphogenesis and growth
    Francesco Cecconi
    Dulbecco Telethon Institute, Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Development 131:2125-35. 2004
    ..Furthermore, the otic vesicle failed to close completely in all double mutant embryos analyzed. These results indicate important roles for both Apaf1 and Bcl2l in inner ear development...
  24. pmc New insights into the link between DNA damage and apoptosis
    Daniela De Zio
    Dulbecco Telethon Institute at the Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Antioxid Redox Signal 19:559-71. 2013
    ..When lesions are unrepaired or there are defects in the DNA repair system, DNA damage is often correlated to apoptosis. However, different kinds of lesions and different degrees of lesion severity can trigger numerous signaling responses...
  25. ncbi request reprint Autophagic and apoptotic response to stress signals in mammalian cells
    Elisabetta Ferraro
    Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia, Rome 00143, Italy
    Arch Biochem Biophys 462:210-9. 2007
    ..Besides discussing the individual roles played by the key molecules involved in autophagy in mammals in response to stress signals, we discuss here the interrelations between autophagy and apoptosis under these conditions...
  26. doi request reprint Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis
    Diego Centonze
    Neurologic Clinic, Department of Neuroscience, Tor Vergata University, 00133 Rome, Italy
    J Neurosci 29:3442-52. 2009
    ..Our data establish a link between neuroinflammation and synaptic degeneration and calls for early neuroprotective therapies in chronic inflammatory diseases of the CNS...
  27. ncbi request reprint Schwann cell autophagy counteracts the onset and chronification of neuropathic pain
    Sara Marinelli
    CNR National Research Council, Cell Biology and Neurobiology Institute, Rome, Italy Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Fondazione Santa Lucia, Rome, Italy
    Pain 155:93-107. 2014
    ....
  28. pmc S-nitrosoglutathione reductase deficiency-induced S-nitrosylation results in neuromuscular dysfunction
    Costanza Montagna
    1 Research Center, IRCCS San Raffaele Pisana, Rome, Italy
    Antioxid Redox Signal 21:570-87. 2014
    ..Here, we aim at assessing this issue by characterizing the neuromuscular phenotype of S-nitrosoglutathione reductase-null (GSNOR-KO) mice that maintain the capability to produce NO, but are unable to reduce SNOs...
  29. pmc Zebrafish ambra1a and ambra1b knockdown impairs skeletal muscle development
    Tatjana Skobo
    Department of Biology, University of Padova, Padova, Italy
    PLoS ONE 9:e99210. 2014
    ..The morphants phenotypes were effectively rescued by co-injection with human AMBRA1 mRNA. Together, these results indicate that ambra1a and ambra1b are required for the correct development and morphogenesis of skeletal muscle. ..
  30. ncbi request reprint Apoptosome impairment during development results in activation of an autophagy program in cerebral cortex
    Sandra Moreno
    Department of Biology LIME, University Roma Tre, 00146, Rome, Italy
    Apoptosis 11:1595-602. 2006
    ....
  31. doi request reprint The role of autophagy during development in higher eukaryotes
    Sabrina Di Bartolomeo
    Dulbecco Telethon Institute, Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Traffic 11:1280-9. 2010
    ..In light of such evidence, it can be concluded that there is a close interplay between autophagy and the processes of cell death, proliferation and differentiation that determine the development of higher eukaryotes...
  32. ncbi request reprint Apoptosome inactivation rescues proneural and neural cells from neurodegeneration
    M Cozzolino
    Dulbecco Telethon Institute, Department of Biology, University of Rome Tor Vergata, 00133 Rome, Italy
    Cell Death Differ 11:1179-91. 2004
    ..Indeed, the ETNA cell model is ideally suited for exploring the potential of novel cell therapies for the treatment of human neurodegenerations...
  33. doi request reprint Ho(a)xing autophagy to regulate development
    Silvia Campello
    IRCCS Fondazione Santa Lucia, 00143 Rome, Italy
    Dev Cell 28:3-4. 2014
    ..This regulation involves repression of the Atg genes. Programmed developmental autophagy is thus under Hox control and may influence cell fate determination. ..
  34. pmc Oxidative DNA damage in neurons: implication of ku in neuronal homeostasis and survival
    Daniela De Zio
    Department of Biology, Dulbecco Telethon Institute, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    Int J Cell Biol 2012:752420. 2012
    ..In light of recent findings, in this paper, we will discuss the possible implication of Ku in neurodevelopment and in mediating the DNA repair dysfunction observed in certain neurodegenerations...
  35. ncbi request reprint Physiological and pathological roles of Apaf1 and the apoptosome
    E Ferraro
    Dulbecco Telethon Institute at the Department of Biology, University of Tor Vergata, Rome, Italy
    J Cell Mol Med 7:21-34. 2003
    ..In particular, we discuss here some recent evidences regarding the putative role of the apoptosome in neurodegeneration and cancer...
  36. ncbi request reprint Neuronal caspase-3 signaling: not only cell death
    M D'Amelio
    Dulbecco Telethon Institute, Department of Biology, University of Rome Tor Vergata, Rome, Italy
    Cell Death Differ 17:1104-14. 2010
    ..Fine-tuning of caspase-3 lays down a new challenge in identifying pharmacological avenues for treatment of many neurological disorders...
  37. pmc Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    Daniel J Klionsky
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Autophagy 4:151-75. 2008
    ..In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response...
  38. ncbi request reprint Ambra1 regulates autophagy and development of the nervous system
    Gian Maria Fimia
    National Institute for Infectious Diseases, IRCCS L Spallanzani, 00149 Rome, Italy
    Nature 447:1121-5. 2007
    ....
  39. ncbi request reprint Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells
    Michael Bitzer
    Department of Internal Medicine I, University Clinic Tübingen, D 72076 Tubingen, Germany
    J Biol Chem 277:29817-24. 2002
    ..Our results therefore suggest an alternative mechanism for caspase-9 activation in virally infected cells beside the well characterized pathways via death receptors or mitochondrial cytochrome c release...
  40. ncbi request reprint Nonapoptotic role for Apaf-1 in the DNA damage checkpoint
    Yael Zermati
    INSERM, U848, 94805 Villejuif, France
    Mol Cell 28:624-37. 2007
    ..Hence, Apaf-1 exerts two distinct, phylogenetically conserved roles in response to mitochondrial membrane permeabilization and DNA damage. These data point to a role for Apaf-1 as a bona fide tumor suppressor...
  41. pmc Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death
    Sean P Cregan
    Ottawa Health Research Institute, Department of Neuroscience, University of Ottawa, Ontario, Canada, K1H 8M5
    J Cell Biol 158:507-17. 2002
    ..Taken together, our results suggest that AIF may be an important therapeutic target for the treatment of neuronal injury...
  42. ncbi request reprint Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
    Vanessa S Marsden
    The Walter and Eliza Hall Institute, Melbourne, 3050, Australia
    Nature 419:634-7. 2002
    ..We conclude that Bcl-2 regulates a caspase activation programme independently of the cytochrome c/Apaf-1/caspase-9 'apoptosome', which seems to amplify rather than initiate the caspase cascade...
  43. ncbi request reprint Caspase regulation of genotoxin-induced neural precursor cell death
    Cleta D'Sa
    Division of Neuropathology, Department of Pathology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    J Neurosci Res 74:435-45. 2003
    ..These studies suggest that caspase-9 activation is both necessary and sufficient for genotoxin-induced neural precursor cell reactive oxygen species generation and death...
  44. ncbi request reprint Conditional activation of Pax6 in the developing cortex of transgenic mice causes progenitor apoptosis
    Joachim Berger
    Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    Development 134:1311-22. 2007
    ..The results provide new evidence for the complex role of Pax6 in mammalian corticogenesis...