Germana Cecchini

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint Anti-inflammatory and immunomodulating properties of statins. An additional tool for the therapeutic approach of systemic autoimmune diseases?
    Pier Luigi Meroni
    Allergy and Clinical Immunology Unit, Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Clin Rev Allergy Immunol 23:263-77. 2002
  2. ncbi request reprint Endothelium as a target for anti-phospholipid antibodies and for therapeutical intervention
    Pier Luigi Meroni
    Allergy and Clinical Immunology Unit, Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, via L Ariosto 13, 20145 Milan, Italy
    Autoimmun Rev 1:55-60. 2002
  3. doi request reprint Antinucleosome antibodies in primary antiphospholipid syndrome: a hint at systemic autoimmunity?
    Laura Andreoli
    Rheumatology and Clinical Immunology Unit, Spedali Civili, Piazzale Spedali Civili 1, University of Brescia, 25123 Brescia, Italy
    J Autoimmun 30:51-7. 2008
  4. doi request reprint Pathogenesis of the antiphospholipid syndrome: an additional example of the mosaic of autoimmunity
    Pier Luigi Meroni
    Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy
    J Autoimmun 30:99-103. 2008
  5. doi request reprint Tumour Necrosis Factor α Antagonists in the Treatment of Rheumatoid Arthritis: An Immunological Perspective
    Pier Luigi Meroni
    Divisione di Reumatologia, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
    BioDrugs 28:5-13. 2014
  6. doi request reprint Automated tests of ANA immunofluorescence as throughput autoantibody detection technology: strengths and limitations
    Pier Luigi Meroni
    Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
    BMC Med 12:38. 2014
  7. ncbi request reprint Potential effect of anti-inflammatory treatment on reducing the cardiovascular risk in rheumatoid arthritis
    Cecilia Chighizola
    Division of Rheumatology, Istituto Ortopedico Gaetano Pini, Department of Internal Medicine, University of Milan, Italy
    Curr Vasc Pharmacol 10:639-46. 2012
  8. doi request reprint Obstetric and vascular APS: same autoantibodies but different diseases?
    P L Meroni
    Division of Rheumatology, Istituto G Pini, Milan, Italy
    Lupus 21:708-10. 2012
  9. doi request reprint Preliminary evaluation of the first international reference preparation for anticitrullinated peptide antibodies
    Nicola Bizzaro
    Laboratory of Clinical Pathology, Civic Hospital, Tolmezzo, Italy
    Ann Rheum Dis 71:1388-92. 2012
  10. pmc Adalimumab clinical efficacy is associated with rheumatoid factor and anti-cyclic citrullinated peptide antibody titer reduction: a one-year prospective study
    Fabiola Atzeni
    Rheumatology Unit, Department of Medicine, L Sacco University Hospital, 74 Via GB Grassi, 20157 Milano, Italy
    Arthritis Res Ther 8:R3. 2006

Detail Information

Publications70

  1. ncbi request reprint Anti-inflammatory and immunomodulating properties of statins. An additional tool for the therapeutic approach of systemic autoimmune diseases?
    Pier Luigi Meroni
    Allergy and Clinical Immunology Unit, Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Clin Rev Allergy Immunol 23:263-77. 2002
    ....
  2. ncbi request reprint Endothelium as a target for anti-phospholipid antibodies and for therapeutical intervention
    Pier Luigi Meroni
    Allergy and Clinical Immunology Unit, Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, via L Ariosto 13, 20145 Milan, Italy
    Autoimmun Rev 1:55-60. 2002
    ....
  3. doi request reprint Antinucleosome antibodies in primary antiphospholipid syndrome: a hint at systemic autoimmunity?
    Laura Andreoli
    Rheumatology and Clinical Immunology Unit, Spedali Civili, Piazzale Spedali Civili 1, University of Brescia, 25123 Brescia, Italy
    J Autoimmun 30:51-7. 2008
    ..Patients with primary antiphospholipid syndrome (PAPS) may develop full-blown SLE but there is no evidence for markers predictive for that...
  4. doi request reprint Pathogenesis of the antiphospholipid syndrome: an additional example of the mosaic of autoimmunity
    Pier Luigi Meroni
    Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy
    J Autoimmun 30:99-103. 2008
    ..Altogether these findings do support the concept of a mosaic of factors that participate to the pathogenesis of the syndrome at different levels...
  5. doi request reprint Tumour Necrosis Factor α Antagonists in the Treatment of Rheumatoid Arthritis: An Immunological Perspective
    Pier Luigi Meroni
    Divisione di Reumatologia, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
    BioDrugs 28:5-13. 2014
    ....
  6. doi request reprint Automated tests of ANA immunofluorescence as throughput autoantibody detection technology: strengths and limitations
    Pier Luigi Meroni
    Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
    BMC Med 12:38. 2014
    ..However, these techniques require further validation in clinical studies and need improvement in their recognition of mixed or less common staining patterns. ..
  7. ncbi request reprint Potential effect of anti-inflammatory treatment on reducing the cardiovascular risk in rheumatoid arthritis
    Cecilia Chighizola
    Division of Rheumatology, Istituto Ortopedico Gaetano Pini, Department of Internal Medicine, University of Milan, Italy
    Curr Vasc Pharmacol 10:639-46. 2012
    ..Here we provide an extensive review of the literature, focusing on the effects of the available anti-rheumatic agents on cardiovascular mortality, and morbidity among RA sufferers...
  8. doi request reprint Obstetric and vascular APS: same autoantibodies but different diseases?
    P L Meroni
    Division of Rheumatology, Istituto G Pini, Milan, Italy
    Lupus 21:708-10. 2012
    ..A different pathogenesis may also provide the rationale for the well-known fact that the vascular and the obstetric manifestations may occur independently although in a minority of cases...
  9. doi request reprint Preliminary evaluation of the first international reference preparation for anticitrullinated peptide antibodies
    Nicola Bizzaro
    Laboratory of Clinical Pathology, Civic Hospital, Tolmezzo, Italy
    Ann Rheum Dis 71:1388-92. 2012
    ..A lyophilised reference serum from one patient with rheumatoid arthritis (RA) diluted with serum samples from healthy subjects was evaluated as a possible first international standard for anticitrullinated peptide antibodies (ACPAs)...
  10. pmc Adalimumab clinical efficacy is associated with rheumatoid factor and anti-cyclic citrullinated peptide antibody titer reduction: a one-year prospective study
    Fabiola Atzeni
    Rheumatology Unit, Department of Medicine, L Sacco University Hospital, 74 Via GB Grassi, 20157 Milano, Italy
    Arthritis Res Ther 8:R3. 2006
    ..Antinuclear and anti-dsDNA autoantibodies, but not anti-phospholipid autoantibodies, can be induced by adalimumab but to a lower extent than in studies with other anti-TNF blocking agents...
  11. ncbi request reprint Humoral autoimmunity against endothelium: theory or reality?
    Pierluigi Meroni
    Allergy, Clinical Immunology and Rheumatology Unit, IRCCS Istituto Auxologico Italiano, Department of Internal Medicine, University of Milan, Italy
    Trends Immunol 26:275-81. 2005
    ..These autoantibodies recognize beta2 glycoprotein I adhered to the endothelium and induce a cell perturbation that might underlie the thrombophilic state of the anti-phospholipid syndrome...
  12. ncbi request reprint Innate immunity in the antiphospholipid syndrome: role of toll-like receptors in endothelial cell activation by antiphospholipid antibodies
    P L Meroni
    Allergy, Clinical Immunology and Rheumatology Unit, Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Via G Spagnoletto, 3, Milan 20149, Italy
    Autoimmun Rev 3:510-5. 2004
    ..Because of the molecular mimicry between beta2GPI and viral/bacterial structures-the natural ligands for TLRs-antibodies might cross-link the molecule associated to annexin II and TLR-4 eventually triggering the signaling...
  13. ncbi request reprint Inflammatory response and the endothelium
    P L Meroni
    Department of Internal Medicine, University of Milan, Istituto Auxologico Italiano, Milan, Italy
    Thromb Res 114:329-34. 2004
    ..As shown in antiphospholipid syndrome experimental animal models, a two-hit hypothesis is suggested...
  14. ncbi request reprint Anti-beta 2 glycoprotein I antibodies in centenarians
    P L Meroni
    Allergy, Clinical Immunology and Rheumatology Unit, Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Via G Spagnoletto 3, 20149 Milan, Italy
    Exp Gerontol 39:1459-65. 2004
    ..Non-organ-specific autoantibodies are present in centenarians without evidence of autoimmune diseases but conflicting or no data on anti-phospholipid and anti-phospholipid binding proteins were reported...
  15. ncbi request reprint Antiphospholipid antibodies as cause of pregnancy loss
    P L Meroni
    Allergy, Clinical Immunology and Rheumatology Unit, IRCCS Istituto Auxologico Italiano, Department of Internal Medicine, University of Milan, Milan, Italy
    Lupus 13:649-52. 2004
    ..These mechanisms have been suggested to play a role in early fetal loss, while thrombotic events would be responsible for miscarriages late in the pregnancy...
  16. doi request reprint Anti-phospholipid antibody mediated fetal loss: still an open question from a pathogenic point of view
    P L Meroni
    Division of Rheumatology, Istituto G Pini, Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan Italy
    Lupus 19:453-6. 2010
    ..Understanding the different pathogenic mechanisms of aPL-associated miscarriages may help in improving our therapeutic approach particularly in recurrent cases not responsive to the usual treatment...
  17. ncbi request reprint Role of anti-beta2 glycoprotein I antibodies in antiphospholipid syndrome: in vitro and in vivo studies
    Pier Luigi Meroni
    Allergy, Clinical Immunology and Rheumatology Unit, IRCCS Istituto Auxologico Italiano, Department of Internal Medicine, University of Milan, Milan, Italy
    Clin Rev Allergy Immunol 32:67-74. 2007
    ..Experimental animal models have supported the in vivo pathogenic role of anti-beta2GPI antibodies in both thrombosis and fetal loss models...
  18. ncbi request reprint Anti-beta 2 glycoprotein I antibodies and the risk of myocardial infarction in young premenopausal women
    P L Meroni
    Department of Internal Medicine, University of Milan, Milan, Italy
    J Thromb Haemost 5:2421-8. 2007
    ..This discrepancy is perhaps related to the confounding effect of traditional risk factors. Among them, coronary atherosclerosis appears to be the most important in studies conducted in middle-aged and elderly patients...
  19. doi request reprint Updating on the pathogenic mechanisms 5 of the antiphospholipid antibodies-associated pregnancy loss
    Pier Luigi Meroni
    Department of Internal Medicine, University of Milan, Milan, Italy
    Clin Rev Allergy Immunol 34:332-7. 2008
    ..As a whole, these findings do suggest that aPL may induce a defective placentation by acting at different levels without involving necessarily thrombotic events...
  20. doi request reprint European Forum on Antiphospholipid Antibodies: research in progress
    P L Meroni
    Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Lupus 18:924-9. 2009
    ..Finally, a study has been planned in order to draw definitive conclusions on the associations between aPL and atherosclerosis...
  21. doi request reprint ANA screening: an old test with new recommendations
    Pier Luigi Meroni
    Division of Rheumatology, Department of Internal Medicine, Istituto G Pini, University of Milan and IRCCS Istituto Auxologico Italiano, Milan, Italy
    Ann Rheum Dis 69:1420-2. 2010
    ..A committee of the American College of Rheumatology was formed to address this issue. Specific recommendations have been suggested that represent a realistic first step in the standardisation of diagnostic tests for autoimmune diseases...
  22. doi request reprint Autoimmune or auto-inflammatory syndrome induced by adjuvants (ASIA): old truths and a new syndrome?
    Pier Luigi Meroni
    Division of Rheumatology, Istituto G Pini, Milan, Italy
    J Autoimmun 36:1-3. 2011
    ..It is an intriguing issue and one that is likely to be provocative and lead to further biologic and molecular investigations...
  23. ncbi request reprint Endothelial cell activation by antiphospholipid antibodies
    P L Meroni
    Allergy, Clinical Immunology and Rheumatology Unit, IRCCS Istituto Auxologico Italiano, Department of Internal Medicine, University of Milan, Milan, Italy
    Clin Immunol 112:169-74. 2004
    ....
  24. ncbi request reprint Should our approach to the anticardiolipin assay change 20 years after its discovery?
    P L Meroni
    Allergy, Clinical Immunology and Rheumatology Unit, IRCCS Istituto Auxologico Italiano, Department of Internal Medicine, University of Milan, Milan, Italy
    J Thromb Haemost 2:1074-6. 2004
  25. ncbi request reprint Venous thromboembolism in the antiphospholipid syndrome: management guidelines for secondary prophylaxis
    P L Meroni
    Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Lupus 12:504-7. 2003
    ..Until such information becomes available, individualized treatment according to the patient's individual risk factors for both bleeding and thrombosis is the general practice...
  26. ncbi request reprint Antiphospholipid antibodies and the endothelium
    P L Meroni
    Allergy and Clinical Immunology Unit, Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Rheum Dis Clin North Am 27:587-602. 2001
    ..The heterogeneity of the APS clinical manifestations is likely linked to the varied effects that aPL can induce on ECs and to the different functions that ECs display depending on the anatomic localization...
  27. ncbi request reprint Modulation of adhesion molecule expression on endothelial cells: to be or not to be?
    P L Meroni
    Allergy, Clinical Immunology and Rheumatology Unit, IRCCS Istituto Auxologico Italiano, Department of Internal Medicine, Milan, Italy
    J Thromb Haemost 1:2280-2. 2003
  28. ncbi request reprint Pathogenic mechanisms mediating antiphospholipid syndrome
    P L Meroni
    Allergy and Clinical Immunology Unit, IRCCS Istituto Auxologico Italiano, Department of Internal Medicine, University of Milan, Italy
    Curr Opin Rheumatol 13:377-82. 2001
    ..Phospholipid binding proteins such as beta 2 -glycoprotein I appear to behave as a bridge between circulating antiphospholipid antibodies and cellular targets...
  29. ncbi request reprint Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype
    P L Meroni
    IRCCS Istituto Auxologico Italiano, Milan, Italy
    Arthritis Rheum 44:2870-8. 2001
    ..To investigate the ability of statins, the inhibitors of the hydroxymethylglutaryl-coenzyme A reductase enzyme, to affect endothelial cell activation induced by anti-beta2-glycoprotein I (anti-beta2GPI) antibodies in vitro...
  30. doi request reprint Patients with antiphospholipid syndrome display endothelial perturbation
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Foundation Maggiore Hospital Policlinico, Mangiagalli, Regina Elena, Italy
    J Autoimmun 34:105-10. 2010
    ..The aim of this observational case-control study was to evaluate several parameters of endothelial perturbation in patients with APS and without any other atherosclerosis risk factor...
  31. pmc Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies
    Silvia S Pierangeli
    Antiphospholipid Standardization Laboratory, Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555 1165, USA
    Ann Rheum Dis 66:1327-33. 2007
    ....
  32. ncbi request reprint Transforming growth factor beta1 in the pathogenesis of autoimmune congenital complete heart block: lesson from twins and triplets discordant for the disease
    Rolando Cimaz
    Clinica Pediatrica, Fondazione Policlinico Mangiagalli, Via Commenda 9, 20122 Milan, Italy
    Arthritis Rheum 54:356-9. 2006
    ..The aim of our study was to investigate polymorphisms of transforming growth factor beta1 (TGFbeta1) and tumor necrosis factor alpha (TNFalpha) genes in twins and triplets discordant for CCHB whose mothers are anti-Ro/La positive...
  33. ncbi request reprint X monosomy in female systemic lupus erythematosus
    Pietro Invernizzi
    Division of Internal Medicine and Liver Unit, Department of Medicine, Surgery and Dentistry, San Paolo Hospital School of Medicine, University of Milan, Via di Rudini 8, 20142 Milan, Italy
    Ann N Y Acad Sci 1110:84-91. 2007
    ..3960, SLE vs. HCs, Student's t-test), thus suggesting that a different mechanism of immune deregulation might be predominant in the female population of patients with SLE...
  34. ncbi request reprint Haemostatic and inflammatory biomarkers in advanced chronic heart failure: role of oral anticoagulants and successful heart transplantation
    Massimo Cugno
    Department of Internal Medicine, University of Milan, Milan, Italy
    Br J Haematol 126:85-92. 2004
    ..Most of these abnormalities parallel each other, tend to normalize in patients treated with OATs and, although reduced, persist in patients undergoing successful heart transplantation, despite the absence of clinical signs of CHF...
  35. ncbi request reprint Lupus anticoagulants and their relationship with the inhibitors against coagulation factor VIII: considerations on the differentiation between the 2 circulating anticoagulants
    Armando Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine and Dermatology, University and Foundation IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Clin Chem 51:1883-5. 2005
  36. ncbi request reprint Impaired bradykinin response to ischaemia and exercise in patients with mild congestive heart failure during angiotensin-converting enzyme treatment. Relationships with endothelial function, coagulation and inflammation
    Massimo Cugno
    Department of Internal Medicine, University of Milan, Milan, Italy
    Br J Haematol 130:113-20. 2005
    ..They are unable to respond adequately to stimuli of ischaemia and physical exercise which both require vasodilation...
  37. ncbi request reprint X chromosome monosomy: a common mechanism for autoimmune diseases
    Pietro Invernizzi
    Division of Internal Medicine, Department of Medicine, Surgery and Dentistry, San Paolo School of Medicine, University of Milan, Italy
    J Immunol 175:575-8. 2005
    ..These data highlight the thesis that chromosome instability is common to women with SSc and AITD and that haploinsufficiency for X-linked genes may be a critical factor for the female predominance of autoimmune diseases...
  38. doi request reprint Antiphospholipid antibodies and the antiphospholipid syndrome: pathogenic mechanisms
    Silvia S Pierangeli
    Division of Rheumatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1165, USA
    Semin Thromb Hemost 34:236-50. 2008
    ..Based on experimental evidence using in vitro and in vivo models, new targeted therapies for treatment and/or prevention of thrombosis and pregnancy loss in antiphospholipid syndrome are proposed...
  39. ncbi request reprint Antibodies to tissue-type plasminogen activator (tPA) in patients with antiphospholipid syndrome: evidence of interaction between the antibodies and the catalytic domain of tPA in 2 patients
    Massimo Cugno
    Department of Internal Medicine and Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Via Pace 15, 20122 Milano, Italy
    Blood 103:2121-6. 2004
    ..Our data indicate that anti-tPA antibodies specifically interacting with the catalytic domain of tPA can be found in patients with APS, representing a possible cause of hypofibrinolysis...
  40. doi request reprint Anti-t-PA antibodies in acute myocardial infarction after thrombolysis with rt-PA
    Massimo Cugno
    Department of Internal Medicine, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Via Pace 9, 20122, Milan, Italy
    Eur J Intern Med 21:25-9. 2010
    ..Reocclusions follow rt-PA treatment in up to 30% of patients within one year. The infusion of rt-PA may induce the production of anti-t-PA antibodies which could interfere with the function of the native t-PA molecule...
  41. doi request reprint Inflammatory and prothrombotic biomarkers in patients with rheumatoid arthritis: effects of tumor necrosis factor-alpha blockade
    Francesca Ingegnoli
    Department of Rheumatology, University of Milan, Istituto Gaetano Pini, Milan, Italy
    J Autoimmun 31:175-9. 2008
    ..We therefore investigated inflammation and coagulation plasma biomarkers before and after infliximab treatment in RA patients...
  42. ncbi request reprint Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies
    Elena Raschi
    Istituto di Ricovero e Aura a Carattere Scientifico Istituto Auxologico Italiano, Allergy and Clinical Immunology Unit, Department of Internal Medicine, University of Milan, Italy
    Blood 101:3495-500. 2003
    ..Our findings demonstrate that anti-beta(2)-GPI antibodies react with their antigen likely associated to a member of the TLR/IL-1 receptor family on the EC surface and directly induce activation...
  43. ncbi request reprint Concomitant disappearance of electrocardiographic abnormalities and of acquired maternal autoantibodies during the first year of life in infants who had QT interval prolongation and anti-SSA/Ro positivity without congenital heart block at birth
    Rolando Cimaz
    Istituti Clinici di Perfezionamento, Milan, Italy
    Arthritis Rheum 48:266-8. 2003
  44. ncbi request reprint Up-date on the antiphospholipid syndrome
    Cristina Luzzana
    Department of Internal Medicine, University of Milan, Italy
    J Nephrol 15:342-8. 2002
    ..In spite of the improvement in our knowledge on the pathogenic mechanisms of the syndrome, the standard therapy is still based on anti-platelet or anticoagulant drugs both for vascular and obstetrical problems...
  45. ncbi request reprint Anti-DNA antibodies: a diagnostic and prognostic tool for systemic lupus erythematosus?
    Piersandro Riboldi
    Allergy, Clinical Immunology and Rheumatology Unit, IRCCS Istituto Auxologico, Department of Internal Medicine, University of Milan, Italy
    Autoimmunity 38:39-45. 2005
    ..Antibody titre detected by EliA and Farr assay correlated with disease activity. These findings would suggest that more than one assay should be useful for SLE diagnosis and monitoring...
  46. ncbi request reprint Antiphospholipid antibodies are associated with an increased risk for chronic renal insufficiency in patients with lupus nephritis
    Gabriella Moroni
    Division of Nephrology and Dialysis, IRCCS Ospedale Maggiore, Milan, Italy
    Am J Kidney Dis 43:28-36. 2004
    ..The aims of this study are to evaluate the prevalence of aPL antibodies in patients with lupus nephritis and assess their prognostic value for thrombosis and pregnancy morbidity and impact on long-term renal outcome...
  47. ncbi request reprint Endothelium as a target for antiphospholipid antibodies
    Piersandro Riboldi
    Allergy and Clinical Immunology Unit, IRCCS Istituto Auxologico Italiano, Department of Internal Medicine University of Milan, Milan, Italy
    Immunobiology 207:29-36. 2003
    ..Altogether these effects cooperate in switching endothelium from an anti-coagulant to a pro-coagulant surface...
  48. ncbi request reprint Anti-tumor necrosis factor alpha therapy normalizes fibrinolysis impairment in patients with active rheumatoid arthritis
    F Ingegnoli
    Department of Rheumatology, University of Milan, Istituto Gaetano Pini, Milan, Italy
    Clin Exp Rheumatol 28:254-7. 2010
    ..We carried out an observational study investigating plasma biomarkers of inflammation and fibrinolysis in RA patients before and after 14 weeks of infliximab treatment given according to the therapeutic guidelines for RA...
  49. ncbi request reprint Laparoscopic excision of ovarian cysts does not result in antiovarian humoral autoimmunity
    Ilda Chiodo
    Department of Obstetrics, Gynecology and Neonatology, Fondazione Policlinico Mangiagalli Regina Elena, Milan, Italy
    Fertil Steril 84:1772-4. 2005
    ....
  50. doi request reprint Type I interferon therapy and its role in autoimmunity
    Martina Biggioggero
    Clinical Immunology and Rheumatology Unit, Department of Internal Medicine, IRCCS Istituto Auxologico Italiano, University of Milan, Milan, Italy
    Autoimmunity 43:248-54. 2010
    ..IFN therapy cessation is usually, but not always, required for controlling the autoimmune disorders...
  51. doi request reprint The geoepidemiology of the antiphospholipid antibody syndrome
    Martina Biggioggero
    Division of Rheumatology, Department of Internal Medicine University of Milan, Istituto G Pini, Italy
    Autoimmun Rev 9:A299-304. 2010
    ..Their prevalence and titres are lower and the relationship with the APS clinical manifestations are less strong than in the previously mentioned conditions. Ethnicity was also reported to influence the prevalence of aPL...
  52. ncbi request reprint Patients with a history of stable or unstable coronary heart disease have different acute phase responses to an inflammatory stimulus
    José Pablo Werba
    Centro Cardiologico Monzino IRCCS, Milan, Italy
    Atherosclerosis 196:835-40. 2008
    ..66, both p<0.001). The responsiveness of plasma SAA to an inflammatory stimulus in Group 2 alone suggests a pro-inflammatory status in patients prone to acute coronary syndrome but not in those with inducible myocardial ischemia...
  53. doi request reprint The impact of treatment of the fetus by maternal therapy on the fetal and postnatal outcomes for fetuses diagnosed with isolated complete atrioventricular block
    Vlasta Fesslova
    Centre of Fetal Cardiology, Policlinico San Donato, Via Morandi 30, San Donato Milanese, Milan, Italy
    Cardiol Young 19:282-90. 2009
    ..to analyse retrospectively the data of fetuses diagnosed with isolated complete atrioventricular block and efficacy of treatment of the fetus by maternal therapy...
  54. ncbi request reprint Evaluation of current methods for the measurement of serum anti double-stranded DNA antibodies
    Anna Ghirardello
    Division of Rheumatology, University of Padova, Italy
    Ann N Y Acad Sci 1109:401-6. 2007
    ..In the present article, an overview of current methods for anti-dsDNA antibody detection is presented, together with a look at the future trends in technologies newly employed in this field...
  55. ncbi request reprint Are cardiovascular diseases a subspeciality of clinical immunology?
    Pier Luigi Meroni
    Allergy and Clinical Immunology Unit, Department of Internal Medicine, University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Clin Rev Allergy Immunol 23:243-5. 2002
  56. pmc Kallikreins and lupus nephritis
    Claudio Ponticelli
    Division of Nephrology, IRCCS Istituto Clinico Humanitas, Milan, Italy
    J Clin Invest 119:768-71. 2009
    ....
  57. ncbi request reprint Antifibroblast antibodies from systemic sclerosis patients are internalized by fibroblasts via a caveolin-linked pathway
    Nicoletta Ronda
    Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    Arthritis Rheum 46:1595-601. 2002
    ..This study was undertaken to investigate the mechanisms of the interaction between AFAs and living fibroblasts...
  58. ncbi request reprint Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients
    Ricard Cervera
    Institut Clínic d Infeccions i Immunologia ICII, Hospital Clinic, and Institut d Investigacions Biomè diques August Pi i Sunyer IDIBAPS, Barcelona, Catalonia, Spain
    Arthritis Rheum 46:1019-27. 2002
    ..To analyze the clinical and immunologic manifestations of antiphospholipid syndrome (APS) in a large cohort of patients and to define patterns of disease expression...
  59. ncbi request reprint Anti-52 kDa Ro, anti-60 kDa Ro, and anti-La antibody profiles in neonatal lupus
    Patrick Gordon
    Department of Rheumatology, King s College Hospital, London SE5 9RS, UK
    J Rheumatol 31:2480-7. 2004
    ..In addition, the control patients were not disease matched. We reassessed the sensitivity and specificity of anti-52 kDa Ro, anti-60 kDa Ro, and anti-La, addressing these limitations...
  60. pmc IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease
    Paola Bossù
    Laboratory of Clinical and Behavioral Neurology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, 00179 Rome, Italy
    Proc Natl Acad Sci U S A 100:14181-6. 2003
    ..These studies support the concept that IL-18 plays a major role in the pathogenesis of the autoimmune syndrome of lpr mice and that a reduction in IL-18 activity could be a therapeutic strategy in autoimmune diseases...
  61. ncbi request reprint Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis
    Carlo Chizzolini
    Geneva University Hospital, Geneva, Switzerland
    Arthritis Rheum 46:1602-13. 2002
    ..This study was undertaken to investigate whether IgG from SSc sera that react with human fibroblasts modulates the fibroblasts' function...
  62. ncbi request reprint Statins and autoimmune diseases
    Victor S Gurevich
    Mechnicov s State Medical Academy, The Center of Atherosclerosis and Lipid Disorders, Tel Hashomer, Israel
    Autoimmun Rev 4:123-9. 2005
    ..This review discusses the anti-inflammatory and immunomodulatory roles of statins and their possible use for the treatment of other inflammatory diseases or conditions with the involvement of the immune system...
  63. ncbi request reprint A novel autoantigen to differentiate limited cutaneous systemic sclerosis from diffuse cutaneous systemic sclerosis: the interferon-inducible gene IFI16
    Michele Mondini
    Medical School of Turin, Turin, and Medical School of Piemonte Orientale, Novara, Italy
    Arthritis Rheum 54:3939-44. 2006
    ..To investigate the presence and clinical significance of autoantibodies against the interferon-inducible gene IFI16 in systemic sclerosis (SSc), systemic lupus erythematosus (SLE), and other autoimmune diseases...
  64. ncbi request reprint Anti-beta-2 glycoprotein I antibodies affect Bcl-2 and Bax trophoblast expression without evidence of apoptosis
    Nicoletta Di Simone
    Department of Obstetrics and Gynecology, Università Cattolica de Sacro Cuore, Rome, Italy
    Ann N Y Acad Sci 1069:364-76. 2006
    ..In Conclusion, anti-beta2GPI antibodies react with trophoblast cells and reduce the Bcl-2/Bax ratio, but without any clear apoptotic effect...
  65. ncbi request reprint Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model
    Dardo E Ferrara
    Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Arthritis Rheum 48:3272-9. 2003
    ..This study uses an in vivo mouse model to investigate whether fluvastatin has an effect on decreasing both the adhesion of leukocytes to ECs and the thrombus formation induced by aPL...
  66. doi request reprint Antiphospholipid syndrome dilemmas still to be solved: 2008 status
    Yehuda Shoenfeld
    Ann Rheum Dis 67:438-42. 2008
  67. ncbi request reprint Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders
    Michele Mondini
    Department of Public Health and Microbiology, Medical School, University of Turin, V Santena 9, 10126, Turin, Italy
    Ann N Y Acad Sci 1110:47-56. 2007
    ..In this article the role of the IFI16 protein and its corresponding autoantibodies in the etiopathogenesis of systemic autoimmune diseases, in which chronic inflammation is involved, are discussed...
  68. ncbi request reprint Accelerated atherosclerosis in autoimmune rheumatic diseases
    Yehuda Shoenfeld
    Department of Medicine B, Center for Autoimmune Diseases, Sheba Medical Center Tel Hashomer, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Circulation 112:3337-47. 2005
  69. ncbi request reprint Autoantibodies against protective molecules--C1q, C-reactive protein, serum amyloid P, mannose-binding lectin, and apolipoprotein A1: prevalence in systemic lupus erythematosus
    Yehuda Shoenfeld
    Center for Autoimmune Diseases and Department of Medicine B, Chaim Sheba Medical Center, Tel Hashomer, Israel
    Ann N Y Acad Sci 1108:227-39. 2007
    ..These autoantibodies may play a pathogenic role in the development or perpetuation of autoimmunity in SLE...
  70. ncbi request reprint AutoAbSC.Org -- Autoantibody Standardization Committee in 2006
    Edward K L Chan
    Department of Oral Biology, University of Florida, Health Science Center, 1600 SW Archer Road, Gainesville, FL 32610 0424, USA
    Autoimmun Rev 6:577-80. 2007
    ..A web site has been developed under "AutoAbSC.Org" to communicate to the wider stakeholder community and to facilitate ongoing activities in continuing the mission in autoantibody standardization...