Research Topics
| Cristina CecchiSummaryAffiliation: University of Florence Country: Italy Publications
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Detail Information
Publications
Neuronal differentiation of human mesenchymal stromal cells increases their resistance to Aβ42 aggregate toxicityCristina Cecchi
Department of Biochemical Sciences, and Research Centre on the Molecular Basis of Neurodegeneration CIMN, Florence, Italy
J Alzheimers Dis 27:651-64. 2011..These findings extend our knowledge of stem cell vulnerability to amyloid species, which remains a controversial issue, and confirm that amyloid-GM1 interactions play an important role in cell impairment...- A protective role for lipid raft cholesterol against amyloid-induced membrane damage in human neuroblastoma cellsCristina Cecchi
Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
Biochim Biophys Acta 1788:2204-16. 2009..Our data suggest that cholesterol reduces amyloid-induced membrane modifications at the lipid raft level by altering raft physicochemical features... - Differentiation increases the resistance of neuronal cells to amyloid toxicityCristina Cecchi
Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134, Florence, Italy
Neurochem Res 33:2516-31. 2008..Finally, increasing the content of membrane cholesterol resulted in a remarkable reduction of vulnerability and ability to bind the aggregates in either undifferentiated and differentiated cells... - Seladin-1/DHCR24 protects neuroblastoma cells against Abeta toxicity by increasing membrane cholesterol contentC Cecchi
Department of Biochemical Sciences, University of Florence, Florence, Italy
J Cell Mol Med 12:1990-2002. 2008..Our findings extend recently reported data indicating that seladin-1 overexpression directly enhances the resistance to Abeta toxicity featuring seladin-1/DHCR 24 as a possible new susceptibility gene for sporadic AD... 
Replicating neuroblastoma cells in different cell cycle phases display different vulnerability to amyloid toxicityCristina Cecchi
Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134, Florence, Italy
J Mol Med (Berl) 86:197-209. 2008..The high vulnerability of S cells to aggregate toxicity extends previous data suggesting that neuronal loss in AD could result from mitotic reactivation of terminally differentiated neurons with arrest in the S phase...- Increased susceptibility to amyloid toxicity in familial Alzheimer's fibroblastsCristina Cecchi
Department of Biochemical Sciences, University of Florence, Florence, Italy
Neurobiol Aging 28:863-76. 2007..These findings provide compelling evidence that cells bearing increased membrane lipoperoxidation are more susceptible to aggregate toxicity as a result of their reduced ability to counteract amyloid oligomeric attack... - Differing molecular mechanisms appear to underlie early toxicity of prefibrillar HypF-N aggregates to different cell typesCristina Cecchi
Department of Biochemical Sciences, University of Florence, Italy
FEBS J 273:2206-22. 2006.... - Protective effect of new S-acylglutathione derivatives against amyloid-induced oxidative stressAnna Pensalfini
Department of Biochemical Sciences, University of Florence, 50134 Florence, Italy
Free Radic Biol Med 44:1624-36. 2008..Hence, we put forward these derivatives as new antioxidant compounds which could be excellent candidates for therapeutic treatment of AD and other oxidative stress-related diseases... - Membrane cholesterol enrichment prevents Aβ-induced oxidative stress in Alzheimer's fibroblastsAnna Pensalfini
Department of Biochemical Sciences, University of Florence, 50134 Florence, Italy
Neurobiol Aging 32:210-22. 2011..These results identify membrane cholesterol as being key to Aβ42 oligomer accumulation at the cell surfaces and to the following Aβ42-induced cell death in AD neurons... - Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-kappaB, and JNK pathwaysClaudia Fiorillo
Department of Biochemical Sciences University of Florence, 50134 Florence, Italy
Free Radic Biol Med 45:839-46. 2008.... - A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cellsMariagioia Zampagni
Department of Biochemical Sciences, University of Florence, Florence, Italy
J Cell Mol Med 15:2106-16. 2011.... - Lipid rafts are primary mediators of amyloid oxidative attack on plasma membraneMariagioia Zampagni
Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134, Florence, Italy
J Mol Med (Berl) 88:597-608. 2010..These data identify lipid rafts as key mediators of oxidative damage as a result of their ability to recruit aggregates to the cell surface... - Membrane lipid composition and its physicochemical properties define cell vulnerability to aberrant protein oligomersElisa Evangelisti
Department of Biochemical Sciences and Research Centre on the Molecular Basis of Neurodegeneration CIMN, University of Florence, Florence, Italy
J Cell Sci 125:2416-27. 2012..We identified that the degree of toxicity of the oligomeric species is the result of a complex interplay between the structural and physicochemical features of both the oligomers and the cell membrane... - Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease modelsMariagioia Zampagni
Department of Biochemical Sciences, University of Florence, 50134 Florence, Italy
Free Radic Biol Med 52:1362-71. 2012..Collectively, these findings suggest that acyl-SG thioesters could prove useful as a tool for controlling AD-induced cerebral deterioration... - Beneficial effects of poly (ADP-ribose) polymerase inhibition against the reperfusion injury in heart transplantationClaudia Fiorillo
Dipartimento di Scienze Biochimiche, , Viale Morgagni 50, 50134, Fireze, Italia
Free Radic Res 37:331-9. 2003..These latter allow irreversible damages triggered during the ischemic phase to proceed towards apoptosis instead of towards necrosis, as it appears to happen when the energetic pools are depleted by high PARP activity... - SIRT1 modulates MAPK pathways in ischemic-reperfused cardiomyocytesMatteo Becatti
Department of Biochemical Sciences, University of Florence, Florence, Italy
Cell Mol Life Sci 69:2245-60. 2012..These results reveal a new protective mechanism elicited by Resv-induced SIRT1 activation in IR tissues and suggest novel potential therapeutic targets to manage IR-induced cardiac dysfunction... - Glycosaminoglycans (GAGs) suppress the toxicity of HypF-N prefibrillar aggregatesTheodora Saridaki
Department of Biochemical Sciences, University of Florence, Viale Morgagni 50, 50134 Florence, Italy
J Mol Biol 421:616-30. 2012.... - A causative link between the structure of aberrant protein oligomers and their toxicitySilvia Campioni
Department of Biochemical Sciences, University of Florence, Florence, Italy
Nat Chem Biol 6:140-7. 2010..Our findings suggest that structural flexibility and hydrophobic exposure are primary determinants of the ability of oligomeric assemblies to cause cellular dysfunction and its consequences, such as neurodegeneration... - Patterns of cell death triggered in two different cell lines by HypF-N prefibrillar aggregatesMonica Bucciantini
Department of Biochemical Sciences, University of Florence, Florence, Italy
FASEB J 19:437-9. 2005.... - Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's diseaseElisa Evangelisti
Department of Biochemical Sciences, University of Florence, 50134, Florence, Italy
Curr Alzheimer Res 10:143-53. 2013..These findings suggest a specific role for raft domains as primary mediators of amyloid toxicity in AD neurons... - Protective properties of novel S-acyl-glutathione thioesters against ultraviolet-induced oxidative stressDaniel Wright
Department of Biochemical Sciences, University of Florence, Firenze, Florence, Italy
Photochem Photobiol 89:442-52. 2013..Taken together, our findings suggest that acyl-SG thioesters may be therapeutically effective in the treatment of UV-related skin disorders and oxidative stress-mediated conditions in general... - Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patientsCristina Cecchi
Department of Biochemical Sciences, University of Florence, Florence, Italy
Free Radic Biol Med 33:1372-9. 2002..These results support the hypothesis that oxidative damage to lipid, protein, and DNA is an important early event in the pathogenesis of AD... 
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomersBenedetta Mannini
Department of Biochemical Sciences, University of Florence, 50134 Florence, Italy
Proc Natl Acad Sci U S A 109:12479-84. 2012....- Insights into the molecular basis of the differing susceptibility of varying cell types to the toxicity of amyloid aggregatesCristina Cecchi
Department of Biochemical Sciences
J Cell Sci 118:3459-70. 2005..Our data depict membrane destabilization and the subsequent early derangement of ion balance and intracellular redox status as key events in targeting exposed cells to apoptotic death... - Poly(ADP-ribose) polymerase activation and cell injury in the course of rat heart heterotopic transplantationClaudia Fiorillo
Dipartimento di Scienze Biochimiche, , Italy
Free Radic Res 36:79-87. 2002..Our results suggest that during heart transplantation, the activation of PARP, causing energy depletion, results in myocardial cell injury whose dominant feature, at least in our experimental model, is necrosis rather than apoptosis... - Over-expression of amyloid precursor protein in HEK cells alters p53 conformational state and protects against doxorubicinDaniela Uberti
Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia, Italy
J Neurochem 103:322-33. 2007....