G Cavaletti

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi Distribution of paclitaxel within the nervous system of the rat after repeated intravenous administration
    G Cavaletti
    Department of Neurology, University of Milan Bicocca, S Gerardo Hospital, Monza MI, Italy
    Neurotoxicology 21:389-93. 2000
  2. ncbi Carboplatin toxic effects on the peripheral nervous system of the rat
    G Cavaletti
    Istituto di Anatomia Umana, Universita di Milano, Italy
    Ann Oncol 9:443-7. 1998
  3. ncbi Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of the rat
    G Cavaletti
    Clinica Neurologica, A O S Gerardo, Monza, Italy
    Eur J Cancer 37:2457-63. 2001
  4. ncbi Immunomodulating effects of extracorporeal photochemotherapy in rat experimental allergic encephalomyelitis
    G Cavaletti
    Department of Neuroscience, University of Milan Bicocca, Neurologic Unit, S Gerardo Hospital, Monza, Italy
    Int J Tissue React 23:21-31. 2001
  5. ncbi Effect on the peripheral nervous system of systemically administered dimethylsulfoxide in the rat: a neurophysiological and pathological study
    G Cavaletti
    Clinica Neurologica, Universita di Milano Bicocca, Ospedale S Gerardo, v Donizetti 106, 20052 Monza, Italy
    Toxicol Lett 118:103-7. 2000
  6. ncbi Lipid-free versus lipid-bound P2 protein-induced experimental allergic neuritis: clinicopathological, neurophysiological, and immunological study
    G Cavaletti
    Department of Neuroscience, Neurology Unit, S Gerardo Hospital, Monza, Italy
    J Neurosci Res 62:709-16. 2000
  7. ncbi Neuro- and ototoxicity of high-dose carboplatin treatment in poor prognosis ovarian cancer patients
    G Cavaletti
    Clinica Neurologica, Istituto di Scienze Biomediche S Gerardo, Universita di Milano, Monza, Italia
    Anticancer Res 18:3797-802. 1998
  8. ncbi Circulating nerve growth factor level changes during oxaliplatin treatment-induced neurotoxicity in the rat
    G Cavaletti
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italy
    Anticancer Res 22:4199-204. 2002
  9. doi Rasch-built Overall Disability Scale for patients with chemotherapy-induced peripheral neuropathy (CIPN-R-ODS)
    D Binda
    Department of Surgery and Translational Medicine, University of Milan Bicocca, Monza, Italy
    Eur J Cancer 49:2910-8. 2013
  10. doi Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies
    V A Carozzi
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
    Exp Neurol 226:301-9. 2010

Collaborators

Detail Information

Publications27

  1. ncbi Distribution of paclitaxel within the nervous system of the rat after repeated intravenous administration
    G Cavaletti
    Department of Neurology, University of Milan Bicocca, S Gerardo Hospital, Monza MI, Italy
    Neurotoxicology 21:389-93. 2000
    ..The intermediate concentrations of paclitaxel observed in the sciatic nerve and spinal cord may be due to paclitaxel transport along the centrifugal and centripetal branches of the DRG neuron axons...
  2. ncbi Carboplatin toxic effects on the peripheral nervous system of the rat
    G Cavaletti
    Istituto di Anatomia Umana, Universita di Milano, Italy
    Ann Oncol 9:443-7. 1998
    ..However, the use of CBDCA higher-intensity schedules and the association with other neurotoxic drugs in polychemotherapy may cause some concern about its safety with respect to peripheral nervous system damage...
  3. ncbi Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of the rat
    G Cavaletti
    Clinica Neurologica, A O S Gerardo, Monza, Italy
    Eur J Cancer 37:2457-63. 2001
    ....
  4. ncbi Immunomodulating effects of extracorporeal photochemotherapy in rat experimental allergic encephalomyelitis
    G Cavaletti
    Department of Neuroscience, University of Milan Bicocca, Neurologic Unit, S Gerardo Hospital, Monza, Italy
    Int J Tissue React 23:21-31. 2001
    ..the EAE alone rats. We conclude that ECP induces modifications in the immunological events that occur during the course of EAE in rats, thus giving support to the hypothesis that it could be used in the treatment of multiple sclerosis...
  5. ncbi Effect on the peripheral nervous system of systemically administered dimethylsulfoxide in the rat: a neurophysiological and pathological study
    G Cavaletti
    Clinica Neurologica, Universita di Milano Bicocca, Ospedale S Gerardo, v Donizetti 106, 20052 Monza, Italy
    Toxicol Lett 118:103-7. 2000
    ....
  6. ncbi Lipid-free versus lipid-bound P2 protein-induced experimental allergic neuritis: clinicopathological, neurophysiological, and immunological study
    G Cavaletti
    Department of Neuroscience, Neurology Unit, S Gerardo Hospital, Monza, Italy
    J Neurosci Res 62:709-16. 2000
    ....
  7. ncbi Neuro- and ototoxicity of high-dose carboplatin treatment in poor prognosis ovarian cancer patients
    G Cavaletti
    Clinica Neurologica, Istituto di Scienze Biomediche S Gerardo, Universita di Milano, Monza, Italia
    Anticancer Res 18:3797-802. 1998
    ..Hematopoietic toxicity of high-dose carboplatin (HD-CBDCA) chemotherapy can be managed effectively with autologous blood cell support, but no conclusive data are available on its neuro- and ototoxicity...
  8. ncbi Circulating nerve growth factor level changes during oxaliplatin treatment-induced neurotoxicity in the rat
    G Cavaletti
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italy
    Anticancer Res 22:4199-204. 2002
    ..We explored the possible role of some neuronal growth factors ("neurotrophins") during the course of oxaliplatin sensory neuronopathy...
  9. doi Rasch-built Overall Disability Scale for patients with chemotherapy-induced peripheral neuropathy (CIPN-R-ODS)
    D Binda
    Department of Surgery and Translational Medicine, University of Milan Bicocca, Monza, Italy
    Eur J Cancer 49:2910-8. 2013
    ..Its use is recommended in future clinical trials in CIPN...
  10. doi Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies
    V A Carozzi
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
    Exp Neurol 226:301-9. 2010
    ..These results confirm the possibility to use our models to combine the study of the antineoplastic activity of anticancer drugs and of their toxic effects on the peripheral nervous system in the BALB/c mouse strain...
  11. ncbi Early predictors of peripheral neurotoxicity in cisplatin and paclitaxel combination chemotherapy
    G Cavaletti
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italy
    Ann Oncol 15:1439-42. 2004
    ..We investigated the possible use of clinical signs of chemotherapy-induced peripheral neurotoxicity (CIPN) or of nerve growth factor (NGF) circulating levels to predict the final outcome of CIPN...
  12. ncbi The role of oxidative stress and anti-oxidant treatment in platinum-induced peripheral neurotoxicity
    V A Carozzi
    Department of Neurosciences and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
    Curr Cancer Drug Targets 10:670-82. 2010
    ..In this review, an update on the current knowledge on the relationship existing between oxidative stress and platinum drugs peripheral neurotoxicity will be given...
  13. doi In vivo comparative study of the cytotoxicity of a liposomal formulation of cisplatin (lipoplatin™)
    A Canta
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Via Cadore 48, 20052, Monza, MB, Italy
    Cancer Chemother Pharmacol 68:1001-8. 2011
    ....
  14. ncbi Cisplatin-induced peripheral neurotoxicity in rats reduces the circulating levels of nerve growth factor
    G Cavaletti
    Department of Neuroscience, Neurology Unit, S Gerardo Hospital, Via Donizetti 106, 20052 Monza, Italy
    Neurosci Lett 322:103-6. 2002
    ..Our findings are in agreement with previous in vitro and in vivo results and further suggest that NGF plays a specific role in the course of CDDP-induced primary sensory neuron damage...
  15. ncbi Extracorporeal photochemotherapy reduces the severity of Lewis rat experimental allergic encephalomyelitis through a modulation of the function of peripheral blood mononuclear cells
    G Cavaletti
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    J Biol Regul Homeost Agents 18:9-17. 2004
    ..We conclude that ECP modifies the normal activity of PBMC during the course of EAE and it is possible that one of the anti-inflammatory mechanisms of action of ECP is correlated to a down-regulation of T-helper 1 lymphocytes activity...
  16. ncbi Neuropathological changes in the peripheral nervous system and spinal cord in a transgenic mouse model of Niemann-Pick disease type A
    P Marmiroli
    Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Clin Neuropathol 28:263-74. 2009
    ..The aim of our study was to examine the pathological changes occurring in the PNS and in the spinal cord in an AMSKO model of Niemann-Pick disease (NPD) Type A...
  17. ncbi Functionalized mesoporous silica nanoparticles: a possible strategy to target cancer cells reducing peripheral nervous system uptake
    C Ceresa
    Dipartimento di Chirurgia e Medicina Interdisciplinare, Universita di Milano Bicocca, Monza, Italy
    Curr Med Chem 20:2589-600. 2013
    ..Further studies will be necessary in order to confirm if this approach may be useful in reducing neurotocity of anticancer drugs...
  18. ncbi Grading of chemotherapy-induced peripheral neurotoxicity using the Total Neuropathy Scale
    G Cavaletti
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italy
    Neurology 61:1297-300. 2003
    ..The authors concluded that the TNS and TNSr can be used to assess the severity of CIPN effectively, and the results of this evaluation can be reliably correlated with the oncologic grading of sensory peripheral neurotoxicity...
  19. pmc The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings
    G Cavaletti
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    Ann Oncol 24:454-62. 2013
    ..The objective of the study was to select outcome measures for CIPN evaluation and to establish their validity and reproducibility in a cross-sectional multicenter study...
  20. ncbi The effect of Photon Activation Therapy on cisplatin pre-treated human tumour cell lines: comparison with conventional X-ray irradiation
    C Ceresa
    Dipartimento di Chirurgia e Medicina Interdisciplinare UniversitĂ  di Milano Bicocca, Monza, Italy
    J Biol Regul Homeost Agents 27:477-85. 2013
    ..Our results lend additional support to the suggestion that the Photon Activation Therapy in combination with cisplatin treatment should be further explored in relevant in vivo models of glioma and non-glioma cancer models. ..
  21. ncbi Proteasome inhibition: a promising strategy for treating cancer, but what about neurotoxicity?
    A Gilardini
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Curr Med Chem 15:3025-35. 2008
    ..The main results from the use of proteasome inhibition in cancer chemotherapy and the implications for treatment on the nervous system will be reviewed...
  22. ncbi Targeting cancer and neuropathy with histone deacetylase inhibitors: two birds with one stone?
    V Rodriguez-Menendez
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Italy
    Curr Cancer Drug Targets 8:266-74. 2008
    ....
  23. ncbi Pixantrone (BBR2778) reduces the severity of experimental allergic encephalomyelitis
    G Cavaletti
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, and Department of Neurology, S Gerardo Hospital, Monza, Italy
    J Neuroimmunol 151:55-65. 2004
    ..v. administration in humans. Cardiotoxicity was present only in MTX-treated rats. The effectiveness and the favorable safety profile makes pixantrone a most promising immunosuppressant agent for clinical use in multiple sclerosis (MS)...
  24. doi Cerebrospinal fluid levels of BAFF and APRIL in untreated multiple sclerosis
    F Piazza
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore 48, 20052, Monza MI, Italy
    J Neuroimmunol 220:104-7. 2010
    ....
  25. ncbi Current status and future prospects for the treatment of chemotherapy-induced peripheral neurotoxicity
    G Cavaletti
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Eur J Cancer 38:1832-7. 2002
  26. ncbi Effect of trans-resveratrol on signal transduction pathways involved in paclitaxel-induced apoptosis in human neuroblastoma SH-SY5Y cells
    G Nicolini
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Facolta di Medicina e Chirurgia, Via Cadore 48, Universita degli Studi di Milano Bicocca, 20052 Monza, Italy
    Neurochem Int 42:419-29. 2003
    ....
  27. ncbi Vitamin E intake and quality of life in amyotrophic lateral sclerosis patients: a follow-up case series study
    A Galbussera
    Department of Neurology, S Gerardo Hospital and University of Milano Bicocca, Via Donizetti 106, I 20052, Monza MI, Italy
    Neurol Sci 27:190-3. 2006
    ..No differences were seen between the two groups of patients, therefore we do not recommend routine use of vitamin E in ALS patients, at least in the absence of randomised clinical trials specifically designed for addressing this issue...