Research Topics
| G CavalettiSummaryAffiliation: University of Milan Country: Italy Publications
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Detail Information
Publications
Carboplatin toxic effects on the peripheral nervous system of the ratG Cavaletti
Istituto di Anatomia Umana, Universita di Milano, Italy
Ann Oncol 9:443-7. 1998..However, the use of CBDCA higher-intensity schedules and the association with other neurotoxic drugs in polychemotherapy may cause some concern about its safety with respect to peripheral nervous system damage...- Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of the ratG Cavaletti
Clinica Neurologica, A O S Gerardo, Monza, Italy
Eur J Cancer 37:2457-63. 2001.... - Immunomodulating effects of extracorporeal photochemotherapy in rat experimental allergic encephalomyelitisG Cavaletti
Department of Neuroscience, University of Milan Bicocca, Neurologic Unit, S Gerardo Hospital, Monza, Italy
Int J Tissue React 23:21-31. 2001..the EAE alone rats. We conclude that ECP induces modifications in the immunological events that occur during the course of EAE in rats, thus giving support to the hypothesis that it could be used in the treatment of multiple sclerosis... - Effect on the peripheral nervous system of systemically administered dimethylsulfoxide in the rat: a neurophysiological and pathological studyG Cavaletti
Clinica Neurologica, Universita di Milano Bicocca, Ospedale S Gerardo, v Donizetti 106, 20052 Monza, Italy
Toxicol Lett 118:103-7. 2000.... - Lipid-free versus lipid-bound P2 protein-induced experimental allergic neuritis: clinicopathological, neurophysiological, and immunological studyG Cavaletti
Department of Neuroscience, Neurology Unit, S Gerardo Hospital, Monza, Italy
J Neurosci Res 62:709-16. 2000.... - Distribution of paclitaxel within the nervous system of the rat after repeated intravenous administrationG Cavaletti
Department of Neurology, University of Milan Bicocca, S Gerardo Hospital, Monza MI, Italy
Neurotoxicology 21:389-93. 2000..The intermediate concentrations of paclitaxel observed in the sciatic nerve and spinal cord may be due to paclitaxel transport along the centrifugal and centripetal branches of the DRG neuron axons... - Neuro- and ototoxicity of high-dose carboplatin treatment in poor prognosis ovarian cancer patientsG Cavaletti
Clinica Neurologica, Istituto di Scienze Biomediche S Gerardo, Universita di Milano, Monza, Italia
Anticancer Res 18:3797-802. 1998..Hematopoietic toxicity of high-dose carboplatin (HD-CBDCA) chemotherapy can be managed effectively with autologous blood cell support, but no conclusive data are available on its neuro- and ototoxicity... - Circulating nerve growth factor level changes during oxaliplatin treatment-induced neurotoxicity in the ratG Cavaletti
Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italy
Anticancer Res 22:4199-204. 2002..We explored the possible role of some neuronal growth factors ("neurotrophins") during the course of oxaliplatin sensory neuronopathy... 
Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathiesV A Carozzi
Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
Exp Neurol 226:301-9. 2010..These results confirm the possibility to use our models to combine the study of the antineoplastic activity of anticancer drugs and of their toxic effects on the peripheral nervous system in the BALB/c mouse strain...- Early predictors of peripheral neurotoxicity in cisplatin and paclitaxel combination chemotherapyG Cavaletti
Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italy
Ann Oncol 15:1439-42. 2004..We investigated the possible use of clinical signs of chemotherapy-induced peripheral neurotoxicity (CIPN) or of nerve growth factor (NGF) circulating levels to predict the final outcome of CIPN... - The role of oxidative stress and anti-oxidant treatment in platinum-induced peripheral neurotoxicityV A Carozzi
Department of Neurosciences and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
Curr Cancer Drug Targets 10:670-82. 2010..In this review, an update on the current knowledge on the relationship existing between oxidative stress and platinum drugs peripheral neurotoxicity will be given... - In vivo comparative study of the cytotoxicity of a liposomal formulation of cisplatin (lipoplatin™)A Canta
Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Via Cadore 48, 20052, Monza, MB, Italy
Cancer Chemother Pharmacol 68:1001-8. 2011.... - Cisplatin-induced peripheral neurotoxicity in rats reduces the circulating levels of nerve growth factorG Cavaletti
Department of Neuroscience, Neurology Unit, S Gerardo Hospital, Via Donizetti 106, 20052 Monza, Italy
Neurosci Lett 322:103-6. 2002..Our findings are in agreement with previous in vitro and in vivo results and further suggest that NGF plays a specific role in the course of CDDP-induced primary sensory neuron damage... - Extracorporeal photochemotherapy reduces the severity of Lewis rat experimental allergic encephalomyelitis through a modulation of the function of peripheral blood mononuclear cellsG Cavaletti
Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
J Biol Regul Homeost Agents 18:9-17. 2004..We conclude that ECP modifies the normal activity of PBMC during the course of EAE and it is possible that one of the anti-inflammatory mechanisms of action of ECP is correlated to a down-regulation of T-helper 1 lymphocytes activity... - Neuropathological changes in the peripheral nervous system and spinal cord in a transgenic mouse model of Niemann-Pick disease type AP Marmiroli
Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
Clin Neuropathol 28:263-74. 2009..The aim of our study was to examine the pathological changes occurring in the PNS and in the spinal cord in an AMSKO model of Niemann-Pick disease (NPD) Type A... - Grading of chemotherapy-induced peripheral neurotoxicity using the Total Neuropathy ScaleG Cavaletti
Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italy
Neurology 61:1297-300. 2003..The authors concluded that the TNS and TNSr can be used to assess the severity of CIPN effectively, and the results of this evaluation can be reliably correlated with the oncologic grading of sensory peripheral neurotoxicity... - Cerebrospinal fluid levels of BAFF and APRIL in untreated multiple sclerosisF Piazza
Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore 48, 20052, Monza MI, Italy
J Neuroimmunol 220:104-7. 2010.... - Proteasome inhibition: a promising strategy for treating cancer, but what about neurotoxicity?A Gilardini
Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
Curr Med Chem 15:3025-35. 2008..The main results from the use of proteasome inhibition in cancer chemotherapy and the implications for treatment on the nervous system will be reviewed... - Targeting cancer and neuropathy with histone deacetylase inhibitors: two birds with one stone?V Rodriguez-Menendez
Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Italy
Curr Cancer Drug Targets 8:266-74. 2008.... - Pixantrone (BBR2778) reduces the severity of experimental allergic encephalomyelitisG Cavaletti
Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, and Department of Neurology, S Gerardo Hospital, Monza, Italy
J Neuroimmunol 151:55-65. 2004..v. administration in humans. Cardiotoxicity was present only in MTX-treated rats. The effectiveness and the favorable safety profile makes pixantrone a most promising immunosuppressant agent for clinical use in multiple sclerosis (MS)... - Effect of trans-resveratrol on signal transduction pathways involved in paclitaxel-induced apoptosis in human neuroblastoma SH-SY5Y cellsG Nicolini
Dipartimento di Neuroscienze e Tecnologie Biomediche, , Via Cadore 48, , 20052 Monza, Italy
Neurochem Int 42:419-29. 2003.... - Current status and future prospects for the treatment of chemotherapy-induced peripheral neurotoxicityG Cavaletti
Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
Eur J Cancer 38:1832-7. 2002 
The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findingsG Cavaletti
Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
Ann Oncol 24:454-62. 2013..Conclusion Good validity and reliability scores were demonstrated for the set of selected impairment and quality-of-life outcome measures in CIPN. Future studies are planned to investigate the responsiveness aspects of these measures...- Vitamin E intake and quality of life in amyotrophic lateral sclerosis patients: a follow-up case series studyA Galbussera
Department of Neurology, S Gerardo Hospital and University of Milano Bicocca, Via Donizetti 106, I 20052, Monza MI, Italy
Neurol Sci 27:190-3. 2006..No differences were seen between the two groups of patients, therefore we do not recommend routine use of vitamin E in ALS patients, at least in the absence of randomised clinical trials specifically designed for addressing this issue...