G Cavaletti

Summary

Affiliation: University of Milano-Bicocca
Country: Italy

Publications

  1. ncbi request reprint Chemotherapy-induced peripheral neurotoxicity
    Guido Cavaletti
    Universita di Milano Bicocca, Dipartimento di Neuroscienze e Tecnologie Biomediche, V Cadore 48, 20052 Monza MI, Italia
    Expert Opin Drug Saf 3:535-46. 2004
  2. ncbi request reprint Neuronal drug transporters in platinum drugs-induced peripheral neurotoxicity
    Guido Cavaletti
    Department of Surgery and Translational Medicine, University of Milano Bicocca Via Cadore 48, 20900 Monza MB, Italy
    Anticancer Res 34:483-6. 2014
  3. pmc The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings
    G Cavaletti
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    Ann Oncol 24:454-62. 2013
  4. pmc Multimodal assessment of painful peripheral neuropathy induced by chronic oxaliplatin-based chemotherapy in mice
    Cynthia L Renn
    School of Nursing, Center for Pain Studies, University of Maryland, Baltimore, MD, USA
    Mol Pain 7:29. 2011
  5. ncbi request reprint Multi-center assessment of the Total Neuropathy Score for chemotherapy-induced peripheral neurotoxicity
    Guido Cavaletti
    Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Milan, Italy
    J Peripher Nerv Syst 11:135-41. 2006
  6. ncbi request reprint Current status and future prospective of immunointervention in multiple sclerosis
    Guido Cavaletti
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza MI, Italy
    Curr Med Chem 13:2329-43. 2006
  7. ncbi request reprint Bortezomib-induced peripheral neurotoxicity: a neurophysiological and pathological study in the rat
    Guido Cavaletti
    Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Exp Neurol 204:317-25. 2007
  8. ncbi request reprint Emerging role of mitogen-activated protein kinases in peripheral neuropathies
    Guido Cavaletti
    Department of Neurosciences and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    J Peripher Nerv Syst 12:175-94. 2007
  9. ncbi request reprint The Total Neuropathy Score as an assessment tool for grading the course of chemotherapy-induced peripheral neurotoxicity: comparison with the National Cancer Institute-Common Toxicity Scale
    Guido Cavaletti
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italy
    J Peripher Nerv Syst 12:210-5. 2007
  10. ncbi request reprint Neurotoxic effects of antineoplastic drugs: the lesson of pre-clinical studies
    Guido Cavaletti
    Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Front Biosci 13:3506-24. 2008

Detail Information

Publications84

  1. ncbi request reprint Chemotherapy-induced peripheral neurotoxicity
    Guido Cavaletti
    Universita di Milano Bicocca, Dipartimento di Neuroscienze e Tecnologie Biomediche, V Cadore 48, 20052 Monza MI, Italia
    Expert Opin Drug Saf 3:535-46. 2004
    ..Finally, the data available on neuroprotectants, evaluated in the attempt to prevent CIPN, will be summarised...
  2. ncbi request reprint Neuronal drug transporters in platinum drugs-induced peripheral neurotoxicity
    Guido Cavaletti
    Department of Surgery and Translational Medicine, University of Milano Bicocca Via Cadore 48, 20900 Monza MB, Italy
    Anticancer Res 34:483-6. 2014
    ....
  3. pmc The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings
    G Cavaletti
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    Ann Oncol 24:454-62. 2013
    ..The objective of the study was to select outcome measures for CIPN evaluation and to establish their validity and reproducibility in a cross-sectional multicenter study...
  4. pmc Multimodal assessment of painful peripheral neuropathy induced by chronic oxaliplatin-based chemotherapy in mice
    Cynthia L Renn
    School of Nursing, Center for Pain Studies, University of Maryland, Baltimore, MD, USA
    Mol Pain 7:29. 2011
    ..To further characterize the model, we examined nocifensive behavior and central nervous system excitability by in vivo electrophysiological recording of spinal dorsal horn (SDH) wide dynamic range neurons in oxaliplatin-treated mice..
  5. ncbi request reprint Multi-center assessment of the Total Neuropathy Score for chemotherapy-induced peripheral neurotoxicity
    Guido Cavaletti
    Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Milan, Italy
    J Peripher Nerv Syst 11:135-41. 2006
    ..The longer time needed to calculate the TNSr and TNSc in comparison to the ECOG or the NCI-CTC 2.0 scales is offset by the more detailed knowledge of the CIPN characteristics...
  6. ncbi request reprint Current status and future prospective of immunointervention in multiple sclerosis
    Guido Cavaletti
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza MI, Italy
    Curr Med Chem 13:2329-43. 2006
    ....
  7. ncbi request reprint Bortezomib-induced peripheral neurotoxicity: a neurophysiological and pathological study in the rat
    Guido Cavaletti
    Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Exp Neurol 204:317-25. 2007
    ..This model is relevant to the neuropathy induced by bortezomib in the treatment of human malignancies and it could be useful in increasing our knowledge regarding the mechanisms underlying bortezomib neurotoxicity...
  8. ncbi request reprint Emerging role of mitogen-activated protein kinases in peripheral neuropathies
    Guido Cavaletti
    Department of Neurosciences and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    J Peripher Nerv Syst 12:175-94. 2007
    ..In this review, the current knowledge on the role of MAPKs in peripheral neuropathies will be discussed...
  9. ncbi request reprint The Total Neuropathy Score as an assessment tool for grading the course of chemotherapy-induced peripheral neurotoxicity: comparison with the National Cancer Institute-Common Toxicity Scale
    Guido Cavaletti
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italy
    J Peripher Nerv Syst 12:210-5. 2007
    ..Moreover, both the TNS and the TNSc showed a higher sensitivity to CIPN changes. We, therefore, propose the TNSc as a reliable method for assessing not only the severity but also the changes in CIPN...
  10. ncbi request reprint Neurotoxic effects of antineoplastic drugs: the lesson of pre-clinical studies
    Guido Cavaletti
    Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Front Biosci 13:3506-24. 2008
    ..This review will be focused on the most clinically-relevant neurotoxic antineoplastic drugs and on the results obtained with several different classes of putative neuroprotectants...
  11. ncbi request reprint Targeting cancer and neuropathy with histone deacetylase inhibitors: two birds with one stone?
    V Rodriguez-Menendez
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Italy
    Curr Cancer Drug Targets 8:266-74. 2008
    ....
  12. ncbi request reprint The role of growth factors in the prevention and treatment of chemotherapy-induced peripheral neurotoxicity
    Guido Cavaletti
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Curr Drug Saf 1:35-42. 2006
    ..We will review the state-of-the-art of CIPN treatment with growth factors and focus on the future prospects opened up by the most recent pre-clinical and clinical studies...
  13. doi request reprint Chemotherapy-Induced Peripheral Neurotoxicity assessment: a critical revision of the currently available tools
    Guido Cavaletti
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Eur J Cancer 46:479-94. 2010
    ....
  14. doi request reprint Peripheral neuropathy during bortezomib treatment of multiple myeloma: a review of recent studies
    Guido Cavaletti
    Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Leuk Lymphoma 51:1178-87. 2010
    ..BIPN can cause a significant reduction in quality of life, primarily due to severe treatment-emergent pain. Ongoing research may provide additional information about the mechanism of BIPN and strategies to reduce PN...
  15. doi request reprint Chemotherapy-induced peripheral neurotoxicity
    Guido Cavaletti
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore 48, Monza, Italy
    Nat Rev Neurol 6:657-66. 2010
    ....
  16. ncbi request reprint Chemotherapy-induced neuropathy
    Guido Cavaletti
    Department of Neuroscience and Biomedical Technology, University of Milano Bicocca, Via Cadore 48, 20052, Monza, Italy
    Curr Treat Options Neurol 13:180-90. 2011
    ....
  17. ncbi request reprint Grading of chemotherapy-induced peripheral neurotoxicity using the Total Neuropathy Scale
    G Cavaletti
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italy
    Neurology 61:1297-300. 2003
    ..The authors concluded that the TNS and TNSr can be used to assess the severity of CIPN effectively, and the results of this evaluation can be reliably correlated with the oncologic grading of sensory peripheral neurotoxicity...
  18. doi request reprint Chemotherapy-induced peripheral neurotoxicity in the era of pharmacogenomics
    Guido Cavaletti
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    Lancet Oncol 12:1151-61. 2011
    ..However, study data reported so far are inconsistent, which suggests that methodological improvement is needed in clinical trials to obtain reliable results in this clinically relevant area...
  19. ncbi request reprint Extracorporeal photochemotherapy: a safety and tolerability pilot study with preliminary efficacy results in refractory relapsing-remitting multiple sclerosis
    G Cavaletti
    D N T B, University of Milano Bicocca, Via Cadore 48, I 20052 Monza MI, Italy
    Neurol Sci 27:24-32. 2006
    ....
  20. ncbi request reprint Extracorporeal photochemotherapy reduces the severity of Lewis rat experimental allergic encephalomyelitis through a modulation of the function of peripheral blood mononuclear cells
    G Cavaletti
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    J Biol Regul Homeost Agents 18:9-17. 2004
    ..We conclude that ECP modifies the normal activity of PBMC during the course of EAE and it is possible that one of the anti-inflammatory mechanisms of action of ECP is correlated to a down-regulation of T-helper 1 lymphocytes activity...
  21. ncbi request reprint Early predictors of peripheral neurotoxicity in cisplatin and paclitaxel combination chemotherapy
    G Cavaletti
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italy
    Ann Oncol 15:1439-42. 2004
    ..We investigated the possible use of clinical signs of chemotherapy-induced peripheral neurotoxicity (CIPN) or of nerve growth factor (NGF) circulating levels to predict the final outcome of CIPN...
  22. ncbi request reprint Pixantrone (BBR2778) reduces the severity of experimental allergic encephalomyelitis
    G Cavaletti
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, and Department of Neurology, S Gerardo Hospital, Monza, Italy
    J Neuroimmunol 151:55-65. 2004
    ..v. administration in humans. Cardiotoxicity was present only in MTX-treated rats. The effectiveness and the favorable safety profile makes pixantrone a most promising immunosuppressant agent for clinical use in multiple sclerosis (MS)...
  23. ncbi request reprint Circulating nerve growth factor level changes during oxaliplatin treatment-induced neurotoxicity in the rat
    G Cavaletti
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italy
    Anticancer Res 22:4199-204. 2002
    ..We explored the possible role of some neuronal growth factors ("neurotrophins") during the course of oxaliplatin sensory neuronopathy...
  24. ncbi request reprint Thalidomide sensory neurotoxicity: a clinical and neurophysiologic study
    G Cavaletti
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italia
    Neurology 62:2291-3. 2004
    ..The risk of developing sensory neuropathy is around 10% below this threshold but increases with higher doses...
  25. ncbi request reprint Current status and future prospects for the treatment of chemotherapy-induced peripheral neurotoxicity
    G Cavaletti
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Eur J Cancer 38:1832-7. 2002
  26. doi request reprint Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies
    V A Carozzi
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
    Exp Neurol 226:301-9. 2010
    ..These results confirm the possibility to use our models to combine the study of the antineoplastic activity of anticancer drugs and of their toxic effects on the peripheral nervous system in the BALB/c mouse strain...
  27. ncbi request reprint Effect on the peripheral nervous system of systemically administered dimethylsulfoxide in the rat: a neurophysiological and pathological study
    G Cavaletti
    Clinica Neurologica, Universita di Milano Bicocca, Ospedale S Gerardo, v Donizetti 106, 20052 Monza, Italy
    Toxicol Lett 118:103-7. 2000
    ....
  28. doi request reprint Rasch-built Overall Disability Scale for patients with chemotherapy-induced peripheral neuropathy (CIPN-R-ODS)
    D Binda
    Department of Surgery and Translational Medicine, University of Milan Bicocca, Monza, Italy
    Eur J Cancer 49:2910-8. 2013
    ..Its use is recommended in future clinical trials in CIPN...
  29. ncbi request reprint Effects of different schedules of oxaliplatin treatment on the peripheral nervous system of the rat
    G Cavaletti
    Clinica Neurologica, A O S Gerardo, Monza, Italy
    Eur J Cancer 37:2457-63. 2001
    ....
  30. ncbi request reprint Distribution of paclitaxel within the nervous system of the rat after repeated intravenous administration
    G Cavaletti
    Department of Neurology, University of Milan Bicocca, S Gerardo Hospital, Monza MI, Italy
    Neurotoxicology 21:389-93. 2000
    ..The intermediate concentrations of paclitaxel observed in the sciatic nerve and spinal cord may be due to paclitaxel transport along the centrifugal and centripetal branches of the DRG neuron axons...
  31. ncbi request reprint The role of oxidative stress and anti-oxidant treatment in platinum-induced peripheral neurotoxicity
    V A Carozzi
    Department of Neurosciences and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
    Curr Cancer Drug Targets 10:670-82. 2010
    ..In this review, an update on the current knowledge on the relationship existing between oxidative stress and platinum drugs peripheral neurotoxicity will be given...
  32. doi request reprint In vivo comparative study of the cytotoxicity of a liposomal formulation of cisplatin (lipoplatin™)
    A Canta
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Via Cadore 48, 20052, Monza, MB, Italy
    Cancer Chemother Pharmacol 68:1001-8. 2011
    ....
  33. ncbi request reprint Cisplatin-induced peripheral neurotoxicity in rats reduces the circulating levels of nerve growth factor
    G Cavaletti
    Department of Neuroscience, Neurology Unit, S Gerardo Hospital, Via Donizetti 106, 20052 Monza, Italy
    Neurosci Lett 322:103-6. 2002
    ..Our findings are in agreement with previous in vitro and in vivo results and further suggest that NGF plays a specific role in the course of CDDP-induced primary sensory neuron damage...
  34. ncbi request reprint Immunomodulating effects of extracorporeal photochemotherapy in rat experimental allergic encephalomyelitis
    G Cavaletti
    Department of Neuroscience, University of Milan Bicocca, Neurologic Unit, S Gerardo Hospital, Monza, Italy
    Int J Tissue React 23:21-31. 2001
    ..the EAE alone rats. We conclude that ECP induces modifications in the immunological events that occur during the course of EAE in rats, thus giving support to the hypothesis that it could be used in the treatment of multiple sclerosis...
  35. doi request reprint Docetaxel-induced peripheral neuropathy: protective effects of dihydroprogesterone and progesterone in an experimental model
    Ilaria Roglio
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    J Peripher Nerv Syst 14:36-44. 2009
    ..Our study confirmed that neuroactive steroids exert a protective effect on peripheral nerves at different levels, suggesting that they might represent a new therapeutic frontier for patients with chemotherapy-induced neuropathy...
  36. ncbi request reprint Neuro- and ototoxicity of high-dose carboplatin treatment in poor prognosis ovarian cancer patients
    G Cavaletti
    Clinica Neurologica, Istituto di Scienze Biomediche S Gerardo, Universita di Milano, Monza, Italia
    Anticancer Res 18:3797-802. 1998
    ..Hematopoietic toxicity of high-dose carboplatin (HD-CBDCA) chemotherapy can be managed effectively with autologous blood cell support, but no conclusive data are available on its neuro- and ototoxicity...
  37. ncbi request reprint Functionalized mesoporous silica nanoparticles: a possible strategy to target cancer cells reducing peripheral nervous system uptake
    C Ceresa
    Dipartimento di Chirurgia e Medicina Interdisciplinare, Universita di Milano Bicocca, Monza, Italy
    Curr Med Chem 20:2589-600. 2013
    ..Further studies will be necessary in order to confirm if this approach may be useful in reducing neurotocity of anticancer drugs...
  38. ncbi request reprint Neuropathological changes in the peripheral nervous system and spinal cord in a transgenic mouse model of Niemann-Pick disease type A
    P Marmiroli
    Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Clin Neuropathol 28:263-74. 2009
    ..The aim of our study was to examine the pathological changes occurring in the PNS and in the spinal cord in an AMSKO model of Niemann-Pick disease (NPD) Type A...
  39. doi request reprint Role of a pre-existing neuropathy on the course of bortezomib-induced peripheral neurotoxicity
    Francesca Lanzani
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Monza, Italy
    J Peripher Nerv Syst 13:267-74. 2008
    ....
  40. ncbi request reprint Protective effect of erythropoietin and its carbamylated derivative in experimental Cisplatin peripheral neurotoxicity
    Roberto Bianchi
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Clin Cancer Res 12:2607-12. 2006
    ..We have successfully identified derivatives of erythropoietin, including carbamylated erythropoietin, which do not raise the hematocrit but retain the neuroprotective action exerted by erythropoietin...
  41. doi request reprint Cerebrospinal fluid levels of BAFF and APRIL in untreated multiple sclerosis
    F Piazza
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore 48, 20052, Monza MI, Italy
    J Neuroimmunol 220:104-7. 2010
    ....
  42. ncbi request reprint Proteasome inhibition: a promising strategy for treating cancer, but what about neurotoxicity?
    A Gilardini
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Curr Med Chem 15:3025-35. 2008
    ..The main results from the use of proteasome inhibition in cancer chemotherapy and the implications for treatment on the nervous system will be reviewed...
  43. ncbi request reprint Lipid-free versus lipid-bound P2 protein-induced experimental allergic neuritis: clinicopathological, neurophysiological, and immunological study
    G Cavaletti
    Department of Neuroscience, Neurology Unit, S Gerardo Hospital, Monza, Italy
    J Neurosci Res 62:709-16. 2000
    ....
  44. doi request reprint Effect of the chronic combined administration of cisplatin and paclitaxel in a rat model of peripheral neurotoxicity
    Valentina Carozzi
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Via Cadore 48, 20052 Monza MI, Italy
    Eur J Cancer 45:656-65. 2009
    ..We believe that these models may be useful for testing neuroprotective strategies...
  45. ncbi request reprint The effect of Photon Activation Therapy on cisplatin pre-treated human tumour cell lines: comparison with conventional X-ray irradiation
    C Ceresa
    Dipartimento di Chirurgia e Medicina Interdisciplinare UniversitĂ  di Milano Bicocca, Monza, Italy
    J Biol Regul Homeost Agents 27:477-85. 2013
    ..Our results lend additional support to the suggestion that the Photon Activation Therapy in combination with cisplatin treatment should be further explored in relevant in vivo models of glioma and non-glioma cancer models. ..
  46. doi request reprint Beneficial effects of PKF275-055, a novel, selective, orally bioavailable, long-acting dipeptidyl peptidase IV inhibitor in streptozotocin-induced diabetic peripheral neuropathy
    R Bianchi
    Neuromuscular Disease Unit, IRCCS Foundation Carlo Besta Neurological Institute, Via Celoria 11, 20133, Milan, Italy
    J Pharmacol Exp Ther 340:64-72. 2012
    ..The present data support a potential therapeutic effect of PKF275-055 in the treatment of rodent diabetic neuropathy...
  47. ncbi request reprint Drug transporters in chemotherapy induced peripheral neurotoxicity: current knowledge and clinical implications
    C Ceresa
    Department of Neurosciences and Biomedical Technologies, University of Milano Bicocca, Via Cadore 48, 20052 Monza MB, Italy
    Curr Med Chem 18:329-41. 2011
    ....
  48. ncbi request reprint The glutamatergic neurotransmission in the central nervous system
    P Marmiroli
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore 48, 20900 Monza MB, Italy
    Curr Med Chem 19:1269-76. 2012
    ..This chapter will revise the current knowledge in the distribution of glutamate and of its receptors and transporters in the central nervous system...
  49. doi request reprint Expression, distribution and glutamate uptake activity of high affinity-excitatory aminoacid transporters in in vitro cultures of embryonic rat dorsal root ganglia
    V A Carozzi
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore 48, 20900 Monza MB, Italy
    Neuroscience 192:275-84. 2011
    ....
  50. ncbi request reprint Effect of trans-resveratrol on signal transduction pathways involved in paclitaxel-induced apoptosis in human neuroblastoma SH-SY5Y cells
    G Nicolini
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Facolta di Medicina e Chirurgia, Via Cadore 48, Universita degli Studi di Milano Bicocca, 20052 Monza, Italy
    Neurochem Int 42:419-29. 2003
    ....
  51. ncbi request reprint Vitamin E intake and quality of life in amyotrophic lateral sclerosis patients: a follow-up case series study
    A Galbussera
    Department of Neurology, S Gerardo Hospital and University of Milano Bicocca, Via Donizetti 106, I 20052, Monza MI, Italy
    Neurol Sci 27:190-3. 2006
    ..No differences were seen between the two groups of patients, therefore we do not recommend routine use of vitamin E in ALS patients, at least in the absence of randomised clinical trials specifically designed for addressing this issue...
  52. doi request reprint Bortezomib-induced painful neuropathy in rats: a behavioral, neurophysiological and pathological study in rats
    Cristina Meregalli
    Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Eur J Pain 14:343-50. 2010
    ..No pathological alteration in most of DRG satellite cells and neurons was observed. Therefore, this animal model may be useful for studying the neurotoxicity and pain onset mechanisms related to bortezomib treatment...
  53. doi request reprint Glutamate carboxypeptidase inhibition reduces the severity of chemotherapy-induced peripheral neurotoxicity in rat
    Valentina A Carozzi
    Department of Neurosciences and Biomedical Technologies, University of Milano Bicocca, U8, Via Cadore 48, 20052 Monza MB, Italy
    Neurotox Res 17:380-91. 2010
    ..Our data support a novel approach for the treatment of chemotherapy-induced peripheral neuropathy...
  54. doi request reprint The neuroprotective effect of erythropoietin in docetaxel-induced peripheral neuropathy causes no reduction of antitumor activity in 13762 adenocarcinoma-bearing rats
    Ilaria Cervellini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Neurotox Res 18:151-60. 2010
    ..Since CINP induced by DOCE reproduces the clinical utility of taxane in humans, the findings reported might provide a basis for investigating EPO as a neuroprotective agent in patients receiving therapy with DOCE...
  55. doi request reprint The ventral caudal nerve: a physiologic-morphometric study in three different rat strains
    Annalisa Canta
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    J Peripher Nerv Syst 15:140-6. 2010
    ....
  56. doi request reprint NGF protects dorsal root ganglion neurons from oxaliplatin by modulating JNK/Sapk and ERK1/2
    Arianna Scuteri
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita degli Studi di Milano Bicocca, Via Cadore 48, 20052 Monza, Italy
    Neurosci Lett 486:141-5. 2010
    ..However, it is also important, as is JNK/Sapk, in preserving the correct cellular differentiation that is pivotal for neuronal survival...
  57. ncbi request reprint Mesenchymal stem cells neuronal differentiation ability: a real perspective for nervous system repair?
    Arianna Scuteri
    Department of Neurosciences and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    Curr Stem Cell Res Ther 6:82-92. 2011
    ..In this review, we have attempted to shed light on the capacity of MSCs to genuinely differentiate into nervous cells, and to identify the most reliable protocols for obtaining neurons from MSCs for nervous system repair...
  58. doi request reprint Continuous buprenorphine delivery effect in streptozotocine-induced painful diabetic neuropathy in rats
    Annalisa Canta
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Milan, Italy
    J Pain 10:961-8. 2009
    ..Both doses of buprenorphine significantly reversed the diabetes-induced allodynia up to day 7 of treatment. Buprenorphine did not alter either thermal perception or NCV...
  59. doi request reprint Experimental epothilone B neurotoxicity: results of in vitro and in vivo studies
    Alessia Chiorazzi
    Department of Neuroscience and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Neurobiol Dis 35:270-7. 2009
    ..These are the first studies of the neurological effects of epothilone B and they can provide a basis for extending pre-clinical investigation to other members of the epothilone family...
  60. doi request reprint Role of MAPKs in platinum-induced neuronal apoptosis
    Arianna Scuteri
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita degli Studi di Milano Bicocca, Monza, Italy
    Neurotoxicology 30:312-9. 2009
    ..These results suggest a role for the different MAPKs in peripheral neuropathies characterized by apoptosis of DRG neurons...
  61. ncbi request reprint Tubulin: a target for antineoplastic drugs into the cancer cells but also in the peripheral nervous system
    Annalisa Canta
    Department of Neuroscience, University of Milan Bicocca, Via Cadore 48 20052 Monza MI, Italy
    Curr Med Chem 16:1315-24. 2009
    ..The current knowledge regarding the features of epothilones' peripheral neurotoxicity and their comparison with taxanes will be reviewed...
  62. doi request reprint Actively induced EAE in Lewis rats: characterization of spleen and spinal cord infiltrating lymphocytes by flow cytometry during the course of the disease
    Roberta Rigolio
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Via Cadore 48, 20052 Monza, Italy
    J Neuroimmunol 199:67-74. 2008
    ..The increase in both these parameters was observed only in spinal cord infiltrating T cells while relevant changes in spleen cell composition were observed as early as disease onset...
  63. ncbi request reprint Paclitaxel toxicity in post-mitotic dorsal root ganglion (DRG) cells
    Arianna Scuteri
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita degli Studi di Milano Bicocca, Milano, Italy
    Anticancer Res 26:1065-70. 2006
    ....
  64. ncbi request reprint Tissue distribution of glutamate carboxypeptidase II (GCPII) with a focus on the central and peripheral nervous system
    P Marmiroli
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Via Cadore 48, 20900 Monza MB, Italy
    Curr Med Chem 19:1277-81. 2012
    ..In this chapter, we will review the available literature describing the animal and human distribution of glutamate carboxypeptidase in the central and peripheral nervous system...
  65. ncbi request reprint Human platelets express the synaptic markers VGLUT1 and 2 and release glutamate following aggregation
    L Tremolizzo
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Italy
    Neurosci Lett 404:262-5. 2006
    ....
  66. ncbi request reprint Neurotoxicity of platinum compounds: comparison of the effects of cisplatin and oxaliplatin on the human neuroblastoma cell line SH-SY5Y
    Elisabetta Donzelli
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita degli Studi di Milano Bicocca, Monza, Italy
    J Neurooncol 67:65-73. 2004
    ....
  67. ncbi request reprint Valproate protective effects on cisplatin-induced peripheral neuropathy: an in vitro and in vivo study
    Virginia Rodriguez-Menendez
    Department of Neurosciences and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    Anticancer Res 28:335-42. 2008
    ..Valproate (VPA) is an antiepileptic drug recently discovered to remodel gene expression, with hypothetically putative neuroprotective effects...
  68. ncbi request reprint Low-dose cisplatin protects human neuroblastoma SH-SY5Y cells from paclitaxel-induced apoptosis
    Daniela Villa
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Facolta di Medicina e Chirurgia, Monza, Milan, Italy
    Mol Cancer Ther 4:1439-47. 2005
    ..We concluded that low doses of CDDP are protective against toxic doses of paclitaxel and that the possible mechanism of this protection is that the CDDP prevents human neuroblastoma SH-SY5Y cells from achieving mitosis...
  69. ncbi request reprint Focus on the role of Glutamate in the pathology of the peripheral nervous system
    Valentina Carozzi
    Department of Neurosciences e Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    CNS Neurol Disord Drug Targets 7:348-60. 2008
    ..This review will focus on the most recent advances in the research into the role of Glu and the glutamatergic system in the pathology of the peripheral nervous system...
  70. ncbi request reprint Cisplatin-induced peripheral neuropathy: neuroprotection by erythropoietin without affecting tumour growth
    Roberto Bianchi
    Mario Negri Institute of Pharmacological Research, Milan, Italy
    Eur J Cancer 43:710-7. 2007
    ..0 and 1.5 mg/kg twice a week for four weeks) was neuroprotective without influencing the effectiveness of the treatment or tumour growth. EPO thus appears to be an effective neuroprotectant that does not interfere with tumour treatment...
  71. pmc Expression and distribution of 'high affinity' glutamate transporters GLT1, GLAST, EAAC1 and of GCPII in the rat peripheral nervous system
    Valentina Alda Carozzi
    Department of Neurosciences and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
    J Anat 213:539-46. 2008
    ..Therefore, they are important both for understanding glutamatergic signalling in the PNS and for establishing new strategies to treat peripheral neuropathies...
  72. pmc Ascorbic acid in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): a double-blind randomised trial
    Davide Pareyson
    Clinic of Central and Peripheral Degenerative Neuropathies Unit, Department of Clinical Neurosciences, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Foundation, Carlo Besta Neurological Institute, Milan, Italy
    Lancet Neurol 10:320-8. 2011
    ..However, in three 1-year trials, ascorbic acid had no benefit in human beings. We did a multicentre 2-year trial to test the efficacy and tolerability of ascorbic acid in patients with CMT1A...
  73. doi request reprint Cationic liposomes target sites of acute neuroinflammation in experimental autoimmune encephalomyelitis
    Guido Cavaletti
    Department of Neurosciences, University of Milan Bicocca, 20052 Monza, Italy
    Mol Pharm 6:1363-70. 2009
    ..In neuroinflammatory diseases, cationic colloidal carrier particles may enable intervention at affected BBB by an approach which is independent from permeability increase...
  74. ncbi request reprint Neuroactive steroids and peripheral neuropathy
    Ilaria Roglio
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Brain Res Rev 57:460-9. 2008
    ..Therefore, neuroactive steroids, pharmacological agents able to increase their local synthesis and synthetic ligands for their receptors have a promising potential for the treatment of different forms of peripheral neuropathy...
  75. ncbi request reprint An unusual transthyretin gene missense mutation (TTR Phe33Val) linked to familial amyloidotic polyneuropathy
    Roberta Frigerio
    Department of Neuroscience and Biomedical Technologies, University of Milano Bicocca, Monza, Italy
    Amyloid 11:121-4. 2004
    ..This mutation has been previously reported only twice, without complete clinical descriptions...
  76. ncbi request reprint Glutamate transporters in platelets: EAAT1 decrease in aging and in Alzheimer's disease
    Chiara Zoia
    Department of Neuroscience and Biomedical Technology, University of Milano Bicocca, 20052 Mi, Monza, Italy
    Neurobiol Aging 25:149-57. 2004
    ..Platelet glutamate transporters may be used as peripheral markers to investigate the role of glutamate in patients with neuropsychiatric disorders...
  77. ncbi request reprint A new device to study ex-vivo the effects of extracorporeal photochemotherapy on the immune system
    Roberta Rigolio
    Dipartimento di Neuroscienze e Tecnologie Biomediche, Universita di Milano Bicocca, Via Cadore 48, 20052 Monza, Italy
    J Photochem Photobiol B 88:68-75. 2007
    ..Our findings are in line with those previously obtained in humans after complete ECP treatment, thus suggesting that our newly developed device is suitable for investigating the mechanism of action of ECP ex-vivo...
  78. ncbi request reprint Bortezomib-induced peripheral neurotoxicity: still far from a painless gain
    Guido Cavaletti
    Haematologica 92:1308-10. 2007
  79. ncbi request reprint Peripheral neurotoxicity of platinum-based chemotherapy
    Guido Cavaletti
    Nat Rev Cancer 8:1p following 71; author reply 1p following 71. 2008
  80. ncbi request reprint Paclitaxel and Cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine
    Claudio Pisano
    Research and Development, Sigma Tau S p A Industrie Farmaceutiche Riunite, Rome, Italy
    Clin Cancer Res 9:5756-67. 2003
    ..In this study we have tested the hypothesis that ALC may have a protective role on cisplatin and paclitaxel-induced neuropathy...
  81. ncbi request reprint Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis
    Benedetta Mazzanti
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Neuroimmunol 168:111-7. 2005
    ..These findings suggest a similar mechanism of action for pixantrone and mitoxantrone on the effector function of lymphomonocyte B and T cells...
  82. ncbi request reprint Intraepidermal nerve fiber density in rat foot pad: neuropathologic-neurophysiologic correlation
    Giuseppe Lauria
    Immunology and Muscular Pathology Unit, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    J Peripher Nerv Syst 10:202-8. 2005
    ..Our study demonstrated that IENF density quantification correlates with SNCV changes and suggests that this might represent a useful outcome measurement in experimental neuropathies...
  83. ncbi request reprint Morphological and morphometric analysis of paclitaxel and docetaxel-induced peripheral neuropathy in rats
    Elke Persohn
    Novartis Pharma AG, Safety Profiling Assessment, Pathology, Basel, Switzerland
    Eur J Cancer 41:1460-6. 2005
    ..Our results support the hypothesis that taxanes (and particularly docetaxel) may exert their neurotoxic effect not only on the microtubular system of the peripheral nerves, but also on other less obvious targets...
  84. pmc Erythropoietin both protects from and reverses experimental diabetic neuropathy
    Roberto Bianchi
    Mario Negri Institute of Pharmacological Research, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 101:823-8. 2004
    ..These observations suggest that administration of rhEPO or its analogues may be useful in the treatment of diabetic neuropathy...