Marco Cattaneo

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint The P2 receptors and congenital platelet function defects
    Marco Cattaneo
    Unit of Hematology and Thrombosis, Ospedale San Paolo, Department of Medicine, Surgery and Dentistry, DMCO University of Milano, Via di Rudini 8, 20142 Milan, Italy
    Semin Thromb Hemost 31:168-73. 2005
  2. doi request reprint The use of desmopressin in open-heart surgery
    M Cattaneo
    Unita di Ematologia e Trombosi, Ospedale San Paolo, University of Milano, Milano, Italy
    Haemophilia 14:40-7. 2008
  3. doi request reprint Diagnosis and management of high platelet reactivity on treatment with clopidogrel
    Marco Cattaneo
    Dipartimento di Scienze della Salute, Medicina 3, Ospedale San Paolo, Universita degli Studi di Milano, Milano, Italy
    Semin Thromb Hemost 38:645-51. 2012
  4. doi request reprint High on-treatment platelet reactivity--definition and measurement
    M Cattaneo
    Unità di Medicina 3, Ospedale San Paolo, Dipartimento di Scienze della Salute, Universita degli Studi di Milano, Via di Rudini 8, Milan, Italy
    Thromb Haemost 109:792-8. 2013
  5. doi request reprint The clinical relevance of response variability to antiplatelet therapy
    Marco Cattaneo
    Unità di Medicina 3, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Milano, Italy
    Hematology Am Soc Hematol Educ Program 2011:70-5. 2011
  6. doi request reprint Why does ticagrelor induce dyspnea?
    Marco Cattaneo
    Medicina 3, Ospedale San Paolo, Dipartimento di Scienze della Salute, Universita degli Studi di Milano, Milan, Italy
    Thromb Haemost 108:1031-6. 2012
  7. pmc Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes
    Alessandra Balduini
    Biotechnology Laboratories, Department of Molecular Medicine, IRCCS San Matteo Foundation, Universita degli Studi di Pavia, Pavia, Italy
    Haematologica 97:1657-65. 2012
  8. doi request reprint Mechanisms of variability in antiplatelet agents response
    Marco Cattaneo
    Unità di Medicina 3, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Milano, Italy
    Thromb Res 130:S27-8. 2012
  9. doi request reprint Response variability to clopidogrel: is tailored treatment, based on laboratory testing, the right solution?
    M Cattaneo
    Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Unità di Medicina 3, Ospedale San Paolo, Milan, Italy
    J Thromb Haemost 10:327-36. 2012
  10. ncbi request reprint ADP receptors: inhibitory strategies for antiplatelet therapy
    Marco Cattaneo
    Unita di Ematologia e Trombosi, Ospedale San Paolo Universita di Milano, Milano, Italy
    Drug News Perspect 19:253-9. 2006

Collaborators

Detail Information

Publications100

  1. ncbi request reprint The P2 receptors and congenital platelet function defects
    Marco Cattaneo
    Unit of Hematology and Thrombosis, Ospedale San Paolo, Department of Medicine, Surgery and Dentistry, DMCO University of Milano, Via di Rudini 8, 20142 Milan, Italy
    Semin Thromb Hemost 31:168-73. 2005
    ..The localization of both mutations in TM6 and EL3 identifies this region of P2Y (12) as a structurally and functionally critical region of the receptor...
  2. doi request reprint The use of desmopressin in open-heart surgery
    M Cattaneo
    Unita di Ematologia e Trombosi, Ospedale San Paolo, University of Milano, Milano, Italy
    Haemophilia 14:40-7. 2008
    ..Desmopressin has also been used prophylactically in patients undergoing surgical operations characterized by large blood loss and transfusion requirements...
  3. doi request reprint Diagnosis and management of high platelet reactivity on treatment with clopidogrel
    Marco Cattaneo
    Dipartimento di Scienze della Salute, Medicina 3, Ospedale San Paolo, Universita degli Studi di Milano, Milano, Italy
    Semin Thromb Hemost 38:645-51. 2012
    ..When possible, the use of alternative drugs with more uniform and predictable bioavailability and with favorable profiles in terms of risk/benefit and cost/benefit ratios should be preferred...
  4. doi request reprint High on-treatment platelet reactivity--definition and measurement
    M Cattaneo
    Unità di Medicina 3, Ospedale San Paolo, Dipartimento di Scienze della Salute, Universita degli Studi di Milano, Via di Rudini 8, Milan, Italy
    Thromb Haemost 109:792-8. 2013
    ..In addition, the concordance among different tests in the identification of patients at risk is very poor and the most effective and safe treatment for patients at risk is still unknown...
  5. doi request reprint The clinical relevance of response variability to antiplatelet therapy
    Marco Cattaneo
    Unità di Medicina 3, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Milano, Italy
    Hematology Am Soc Hematol Educ Program 2011:70-5. 2011
    ..However, we still need to identify the ideal laboratory test and to answer basic questions on its clinical utility and cost-effectiveness before monitoring clopidogrel therapy can be recommended in clinical practice...
  6. doi request reprint Why does ticagrelor induce dyspnea?
    Marco Cattaneo
    Medicina 3, Ospedale San Paolo, Dipartimento di Scienze della Salute, Universita degli Studi di Milano, Milan, Italy
    Thromb Haemost 108:1031-6. 2012
    ....
  7. pmc Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytes
    Alessandra Balduini
    Biotechnology Laboratories, Department of Molecular Medicine, IRCCS San Matteo Foundation, Universita degli Studi di Pavia, Pavia, Italy
    Haematologica 97:1657-65. 2012
    ..The interaction of adenosine diphosphate with its P2Y(1) and P2Y(12) receptors on platelets is important for platelet function. However, nothing is known about adenosine diphosphate and its function in human megakaryocytes...
  8. doi request reprint Mechanisms of variability in antiplatelet agents response
    Marco Cattaneo
    Unità di Medicina 3, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Milano, Italy
    Thromb Res 130:S27-8. 2012
    ..However, we still need to identify the ideal laboratory test and to answer basic questions on its clinical utility and cost-effectiveness, before monitoring clopidogrel therapy can be recommended in clinical practice...
  9. doi request reprint Response variability to clopidogrel: is tailored treatment, based on laboratory testing, the right solution?
    M Cattaneo
    Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Unità di Medicina 3, Ospedale San Paolo, Milan, Italy
    J Thromb Haemost 10:327-36. 2012
    ....
  10. ncbi request reprint ADP receptors: inhibitory strategies for antiplatelet therapy
    Marco Cattaneo
    Unita di Ematologia e Trombosi, Ospedale San Paolo Universita di Milano, Milano, Italy
    Drug News Perspect 19:253-9. 2006
    ..Along with new the P2Y(12) antagonists, inhibitors of the other platelet receptor for ADP, the antagonists P2Y(1), are under development and may prove to be effective antithrombotic agents...
  11. pmc Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding
    Marco Cattaneo
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Maggiore, University of Milan, 20122 Milan, Italy
    Proc Natl Acad Sci U S A 100:1978-83. 2003
    ..These studies delineate a region of P2Y(12) required for normal function after ADP binding...
  12. ncbi request reprint Disorders of platelet function. Abnormalities of the platelet P2 receptors
    Marco Cattaneo
    Unita di Ematologia e Trombosi, Ospedale San Paolo Università degli Studi di Milano, Milano, Italy
    Pathophysiol Haemost Thromb 35:10-4. 2006
  13. doi request reprint Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of the SSC of the ISTH
    M Cattaneo
    Unità di Medicina III, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita di Milano, Milan, Italy
    J Thromb Haemost 7:1029. 2009
    ..Light transmission aggregometry (LTA) is the most common method used in clinical and research laboratories to assess platelet function. However, the method has never been standardized...
  14. doi request reprint Light transmission aggregometry and ATP release for the diagnostic assessment of platelet function
    Marco Cattaneo
    Unità di Medicina III, Ospedale San Paolo, Universita di Milano, Via di Rudini 8, Milan, Italy
    Semin Thromb Hemost 35:158-67. 2009
    ....
  15. ncbi request reprint Inherited platelet-based bleeding disorders
    M Cattaneo
    Unit of Hematology and Thrombosis, Ospedale San Paolo, Department of Medicine, Surgery and Dentistry, University of Milan, Milan, Italy
    J Thromb Haemost 1:1628-36. 2003
    ..The literature on these disorders is reviewed, and the underlying defects discussed...
  16. ncbi request reprint The platelet P2Y receptors as targets for new antithrombotic drugs
    M Cattaneo
    Unit of Hematology and Thrombosis, Department of Surgery, Medicine and Dentistry, Ospedale San Paolo, University of Milan, Via di Rudini 8, 20142 Milan, Italy
    J Thromb Haemost 1:1133-5. 2003
  17. ncbi request reprint Aspirin and clopidogrel: efficacy, safety, and the issue of drug resistance
    Marco Cattaneo
    Unita di Ematologia e Trombosi, Ospedale San Paolo, Universita di Milano, Via di Rudinì, 8, 20142 Milano, Italy
    Arterioscler Thromb Vasc Biol 24:1980-7. 2004
    ..At present, aspirin and clopidogrel resistance should not be looked for in the clinical setting, because there is no definite demonstration of an association with clinical events conditioning cost-effective changes in patient management...
  18. doi request reprint Bleeding manifestations of congenital and drug-induced defects of the platelet P2Y12 receptor for adenosine diphosphate
    Marco Cattaneo
    Unità di Medicina 3, Ospedale San Paolo Università degli Studi di Milano, Via di Rudini 8, Milan, Italy
    Thromb Haemost 105:S67-74. 2011
    ....
  19. ncbi request reprint Are the bleeding time and PFA-100 useful in the initial screening of patients with mucocutaneous bleedings of hereditary nature?
    M Cattaneo
    Unit of Hematology and Thrombosis, Department of Surgery, Medicine and Dentistry, Ospedale San Paolo, University of Milano, Milano, Italy
    J Thromb Haemost 2:890-1. 2004
  20. doi request reprint Resistance to anti-platelet agents
    Marco Cattaneo
    Unità di Medicina 3 Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Milano, Italy
    Thromb Res 127:S61-3. 2011
    ..The use of new P2Y12 inhibitors, such as prasugrel and ticagrelor, which adequately inhibit P2Y12-dependent platelet function in the vast majority of treated subjects, appears the best solution to the problem of clopidogrel resistance...
  21. doi request reprint The platelet P2Y₁₂ receptor for adenosine diphosphate: congenital and drug-induced defects
    Marco Cattaneo
    Unità di Medicina 3, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Milano, Italy
    Blood 117:2102-12. 2011
    ..Although they increase the incidence of major bleedings, the net clinical benefit is in favor of the new P2Y₁₂ inhibitors...
  22. doi request reprint State of the art of new P2Y12 antagonists
    Marco Cattaneo
    Unità di Medicina III, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odonotoiatria, Universita degli Studi di Milano, Via di Rudini 8, Milan, Italy
    Intern Emerg Med 5:385-91. 2010
    ..A shorter period of drug discontinuation before surgery is necessary in ticagrelor-treated patients compared to clopiodgrel-treated patients to limit the severity of post-surgical bleeding...
  23. doi request reprint New P2Y12 blockers
    M Cattaneo
    Unità di Medicina III, Ospedale San Paolo, Universita di Milano, Milan, Italy
    J Thromb Haemost 7:262-5. 2009
    ..Ticagrelor is the first of a new class of orally available antiplatelet agents antagonizing the effects of ADP mediated by P2Y12; it is currently being studied in a phase III trial in patients with ACS...
  24. pmc Molecular defects of the platelet P2 receptors
    Marco Cattaneo
    Dipartimento di Medicina, Chirurgia e Odontoiatria Unità di Medicina 3 Ospedale San Paolo, Universita degli Studi di Milano, Milan, Italy
    Purinergic Signal 7:333-9. 2011
    ..Tests that evaluate the degree of inhibition of adenylyl cyclase by ADP should be used to confirm the diagnosis...
  25. ncbi request reprint Hyperhomocysteinemia and thrombosis
    M Cattaneo
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Ospedale Maggiore, University of Milano, Italy
    Lipids 36:S13-26. 2001
    ....
  26. ncbi request reprint Hyperhomocysteinemia, atherosclerosis and thrombosis
    M Cattaneo
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Ospedale Maggiore, University of Milano, Italy
    Thromb Haemost 81:165-76. 1999
    ..Not only will they help in defining whether the relationship between hyperhomocysteinemia and thrombosis is causal, they will also have a potential dramatic impact in the prevention of thromboembolic events...
  27. ncbi request reprint High prevalence of hyperchomocysteinemia in patients with inflammatory bowel disease: a pathogenic link with thromboembolic complications?
    M Cattaneo
    A Bianchi Bonomi Hemophilia and Thrombosis Center, and Department of Internal Medicine, IRCCS Ospedale Maggiore, University of Milano, Italy
    Thromb Haemost 80:542-5. 1998
    ..Since they may have impaired absorption of vitamins that regulate the metabolism of homocysteine, we tested the hypothesis that they have hyperhomocysteinemia, an established risk factor for arterial and venous thrombosis...
  28. ncbi request reprint Plasma levels of activated protein C in healthy subjects and patients with previous venous thromboembolism: relationships with plasma homocysteine levels
    M Cattaneo
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, IRCCS Ospedale Maggiore, University of Milano, Italy
    Arterioscler Thromb Vasc Biol 18:1371-5. 1998
    ..This study indicates that APC plasma levels are sensitive markers of activation of the hemostatic system in vivo and that Hcy does not interfere with the activation of PC in vivo...
  29. ncbi request reprint Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet count
    Marco Cattaneo
    Unita di Ematologia e Trombosi, Ospedale San Paolo, DMCO Università di Milan, Milan, Italy
    Haematologica 92:694-7. 2007
    ..Apyrase partially prevented the inhibitory effect of PPP. Therefore, the practice of diluting PRP with PPP to adjust platelet count should be avoided because it artefactually inhibits PA...
  30. ncbi request reprint Laboratory detection of 'aspirin resistance': what test should we use (if any)?
    Marco Cattaneo
    Unita di Ematologia e Trombosi, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita di Milano, Via di Rudini 8, Milano, Italy
    Eur Heart J 28:1673-5. 2007
  31. ncbi request reprint Resistance to antiplatelet drugs: molecular mechanisms and laboratory detection
    M Cattaneo
    Unita di Ematologia e Trombosi, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita di Milano, Milan, Italy
    J Thromb Haemost 5:230-7. 2007
    ..Until then, monitoring of antiplatelet therapy should be considered for investigational purposes only...
  32. doi request reprint Haemorrhagic stroke during anti-platelet therapy
    M Cattaneo
    Unita di Ematologia e Trombosi, Dipartimento di Medicina, Chirurgia e Odontoiatria, Ospedale San Paolo Universita di Milano, Milano, Italy
    Eur J Anaesthesiol Suppl 42:12-5. 2008
    ..The combination of aspirin and vitamin K antagonists may be associated with the heightened risk of cerebral haemorrhage, compared to treatment with either drug alone...
  33. ncbi request reprint The G20210A mutation of the prothrombin gene in patients with previous first episodes of deep-vein thrombosis: prevalence and association with factor V G1691A, methylenetetrahydrofolate reductase C677T and plasma prothrombin levels
    M Cattaneo
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, University of Milano, Italy
    Thromb Res 93:1-8. 1999
    ..Whether it is due to the associated increase in plasma prothrombin levels remains to be established...
  34. ncbi request reprint Platelet P2 receptors: old and new targets for antithrombotic drugs
    Marco Cattaneo
    Universita degli Studi di Milano, Unità di Ematologia e Trombosi Ospedale San Paolo, Via di Rudinì 820142 Milano, Italy
    Expert Rev Cardiovasc Ther 5:45-55. 2007
    ..Along with new P2Y12 antagonists, inhibitors of the other platelet receptor for ADP, P2Y1, and of the receptor for ATP, P2X1, are under development and may prove to be effective antithrombotic agents...
  35. ncbi request reprint Evaluation of the PFA-100 system in the diagnosis and therapeutic monitoring of patients with von Willebrand disease
    M Cattaneo
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University of Milano, Italy
    Thromb Haemost 82:35-9. 1999
    ..The PFA-100 test reflects vWF-dependent platelet function under high shear stress and could be useful in the diagnosis and therapeutic monitoring of patients with vWD...
  36. ncbi request reprint Hyperhomocysteinaemia and atherothrombosis
    M Cattaneo
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Ospedale Maggiore, University of Milan, Italy
    Ann Med 32:46-52. 2000
    ....
  37. ncbi request reprint ADP receptors and clinical bleeding disorders
    M Cattaneo
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy
    Arterioscler Thromb Vasc Biol 19:2281-5. 1999
    ..In addition, it is probably defective in patients with a bleeding diathesis that is characterized by selective impairment of platelet responses to ADP...
  38. ncbi request reprint Evaluation of platelet function with the PFA-100 system in patients with congenital defects of platelet secretion
    M Cattaneo
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milano, Italy
    Thromb Res 96:213-7. 1999
    ..The collagen/epinephrine cartridge is more sensitive than the collagen/adenosine diphosphate cartridge to defects of platelet secretion...
  39. ncbi request reprint Platelets from a patient heterozygous for the defect of P2CYC receptors for ADP have a secretion defect despite normal thromboxane A2 production and normal granule stores: further evidence that some cases of platelet 'primary secretion defect' are heteroz
    M Cattaneo
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine IRCCS Ospedale Maggiore, University of Milan, Milan, Italy
    Arterioscler Thromb Vasc Biol 20:E101-6. 2000
    ....
  40. ncbi request reprint Hyperhomocysteinemia and venous thromboembolism
    Marco Cattaneo
    Hematology and Thrombosis Unit, Hospital San Paolo, University of Milan, Milan, Italy
    Semin Thromb Hemost 32:716-23. 2006
    ....
  41. ncbi request reprint Low plasma levels of vitamin B(6) are independently associated with a heightened risk of deep-vein thrombosis
    M Cattaneo
    Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Ospedale Maggiore, University of Milano, Milano, Italy
    Circulation 104:2442-6. 2001
    ..We investigated whether plasma levels of B vitamins that are involved in Hcy metabolism are associated with an elevated risk of DVT...
  42. ncbi request reprint Prevalence of hyperhomocysteinemia in adult gluten-sensitive enteropathy at diagnosis: role of B12, folate, and genetics
    Simone Saibeni
    Gastroenterology and Gastrointestinal Endoscopy Service, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Clin Gastroenterol Hepatol 3:574-80. 2005
    ..We evaluated the prevalence and the risk factors for hyperhomocysteinemia in patients with newly diagnosed GSE...
  43. ncbi request reprint Abnormalities of homocysteine and B vitamins in the nephrotic syndrome
    Gian Marco Podda
    Centro Emofilia e Trombosi Angelo Bianchi Bonomi, Dipartmento di Medicina Interna e Dermatologia, Fondazione I R C C S Ospedale Maggiore, Mangiagalli e Regina Elena, Universita di Milano, Italy
    Thromb Res 120:647-52. 2007
    ..The prevalence in the nephrotic syndrome of high circulating levels of homocysteine and of low levels of the B vitamins that are involved in its metabolism, which may play a role in thrombosis, is not well defined...
  44. ncbi request reprint Congenital defects of platelet function
    GianMarco Podda
    Medicina III, Azienda Ospedaliera San Paolo, Milano, Italy
    Platelets 23:552-63. 2012
    ..Fibrinolytic inhibitors or the vasopressin analogue desmopressin (DDAVP) should be used in all other circumstances...
  45. doi request reprint The platelet count in EDTA-anticoagulated blood from patients with thrombocytopenia may be underestimated when measured in routine laboratories
    Gian Marco Podda
    Medicina III, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Milan, Italy
    Am J Hematol 87:727-8. 2012
    ..Therefore, time-dependent in vitro platelet agglutination in EDTA-blood samples may cause underestimation of PCs in thrombocytopenic patients, possibly leading to improper management...
  46. pmc Haploinsufficiency of the platelet P2Y12 gene in a family with congenital bleeding diathesis
    Gessica Fontana
    Clinica Medica, Ospedale San Paolo, Universita di Milano, Via di Rudinì, 8, 20142 Milan, Italy
    Haematologica 94:581-4. 2009
    ..The single GL P2Y(12) allele contains normal sequence, while his mother and aunt have the 378delC allele. The results of this study support our hypothesis and illustrate the platelet phenotype associated with P2Y(12) haploinsufficiency...
  47. doi request reprint [Recent advances on the studies of the platelet's inhibition and aggregation. State of the art of new P2Y12 antagonists]
    Greta J Cattaneo
    Unità di Medicina III, Dipartimento di Medicnia, Chirurgia e Odonotoiatria, Ospedale San Paolo, Universita di Milano
    Recenti Prog Med 102:150-5. 2011
    ..A shorter period of drug discontinuation before surgery was necessary in ticagrelor-treated patients compared to clopidogrel-treated patients to limit the severity of post-surgical bleeding...
  48. pmc Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor
    Marco Cattaneo
    Hematology and Thrombosis Unit, Ospedale San Paolo, DMCO University of Milan, Milan, Italy
    Biochem Pharmacol 68:1995-2002. 2004
    ..Thus, all three of the bisphosphate derivatives are highly selective antagonists of the platelet P2Y(1) receptor, and MRS2500 is the most potent such antagonist yet reported...
  49. ncbi request reprint Hyperhomocysteinemia in cerebral vein thrombosis
    Ida Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Maggiore, University of Milan, Italy
    Blood 102:1363-6. 2003
    ..5 (95% CI, 5.7-67.3). In conclusion, hyperhomocysteinemia is associated with a 4-fold increased risk of cerebral vein thrombosis; whether or not its correction with vitamins reduces the risk of the disease remains to be demonstrated...
  50. ncbi request reprint Effects of some pre-analytical conditions on the measurement of homocysteine and cysteine in plasma
    Maddalena L Zighetti
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Ospedale Maggiore, Department of Internal Medicine, Milan, Italy
    Clin Chem Lab Med 42:204-7. 2004
    ..In conclusion, if blood samples for plasma total homocysteine and cysteine measurement cannot be kept on ice, they should be collected in acidic citrate dextrose to minimize the artifactual changes...
  51. ncbi request reprint Blood levels of homocysteine, folate, vitamin B6 and B12 in women using oral contraceptives compared to non-users
    Federico Lussana
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, IRCCS Ospedale Maggiore, Italy
    Thromb Res 112:37-41. 2003
    ..To compare the levels of total homocysteine (tHcy), folate, vitamin B6 and B12, in women not using oral contraceptives (OC) vs. those using OC...
  52. ncbi request reprint Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate
    M Cattaneo
    A Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, Milan, Italy
    Blood 80:2787-96. 1992
    ....
  53. ncbi request reprint Low vitamin B6 levels and the risk of recurrent venous thromboembolism
    Gregor Hron
    Unita di Ematologia e Trombosi, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita di Milano, Milano, Italy
    Haematologica 92:1250-3. 2007
    ..01). Patients with PLP ''23.3 nmol/L had 1.8-fold higher recurrence risk (1.01-3.14) than patients with PLP >23.3 nmol/L (adjusted for confounders including homocysteine). Therefore, low vitamin B6 is a risk factor of recurrent VTE...
  54. ncbi request reprint Determination of total homocysteine in plasma: comparison of the Abbott IMx immunoassay with high performance liquid chromatography
    Maddalena Loredana Zighetti
    Department of Internal Medicine, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan, Via Pace 9, 20122 Milan, Italy
    Haematologica 87:89-94. 2002
    ..The aim of this study was to compare the performance of a commercially available IMx immunoassay with that of a reversed-phase high performance liquid chromatography (HPLC) method for measuring plasma total homocysteine (tHcy)...
  55. ncbi request reprint Antiplatelet agents
    Marco Cattaneo
    Ospedale San Paolo, University of Milano, Milano, Italy
    Hematol J 5:S170-4. 2004
  56. doi request reprint Comparison of different procedures to prepare platelet-rich plasma for studies of platelet aggregation by light transmission aggregometry
    Eti Alessandra Femia
    Medicina III, Azienda Ospedaliera San Paolo e Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Milan, Italy
    Platelets 23:7-10. 2012
    ..Therefore, centrifugation of blood at 200×g or 250×g for 10 min appears to be the best condition for preparing PRP for LTA studies...
  57. ncbi request reprint Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants
    Simone Saibeni
    Gastroenterology and Gastrointestinal Endoscopy Service, Bianchi Bonomi Haemophilia and Thrombosis Center, IRCCS Maggiore Hospital and University of Milan, Milan, Italy
    Am J Gastroenterol 98:112-7. 2003
    ..The aim of this study was to evaluate vitamin B(6) plasma levels in IBD patients...
  58. ncbi request reprint Measurement of warfarin in plasma by high performance liquid chromatography (HPLC) and its correlation with the international normalized ratio
    Rossana Lombardi
    Department of Internal Medicine, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, University and IRCCS Maggiore Hospital, Via Pace 9, Milan 20122, Italy
    Thromb Res 111:281-4. 2003
    ..The method displayed between-run CV of 11.8%. Recovery was 99%. The coefficients of correlation between warfarin concentration in 50 patients and weekly dosage or INR were 0.55 (p<0.0001) or 0.25 (p=0.079)...
  59. ncbi request reprint In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production
    M Cattaneo
    A Bianchi Bonomi Hemophilia and Thrombosis Center, I R C C S Maggiore Hospital, Italy
    Thromb Res 62:717-24. 1991
    ..In conclusion, picotamide inhibits the TxA2/PE-dependent platelet responses to agonists by a double mechanism: (i), TxA2/PE antagonism; (ii) inhibition of thromboxane synthase...
  60. ncbi request reprint Early presence of activated ('exhausted') platelets in malignant tumors (breast adenocarcinoma and malignant melanoma)
    P M Mannucci
    A Bianchi Bonomi Hemophilia and Thrombosis Center, University of Milan, Italy
    Eur J Cancer Clin Oncol 25:1413-7. 1989
    ..Our data indicate that the presence of exhausted platelets is an early finding in patients with malignant tumors...
  61. ncbi request reprint Platelet aggregation at high shear is impaired in patients with congenital defects of platelet secretion and is corrected by DDAVP: correlation with the bleeding time
    M Cattaneo
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, IRCCS Maggiore Hospital, Milano, Italy
    J Lab Clin Med 125:540-7. 1995
    ..Potentiation of platelet aggregation at high shear rate may be one mechanism by which DDAVP shortens the prolonged bleeding time of patients with congenital defects of platelet secretion...
  62. doi request reprint Prediction of optimal warfarin maintenance dose using advanced artificial neural networks
    Enzo Grossi
    Centro Diagnostico Italiano, Milan, Italy
    Pharmacogenomics 15:29-37. 2014
    ..In recent years, pharmacogenetic algorithms were developed for estimating the appropriate dose of vitamin K antagonists...
  63. pmc Bleeding risk during treatment of acute thrombotic events with subcutaneous LMWH compared to intravenous unfractionated heparin; a systematic review
    Giorgio Costantino
    Unità Operativa di Medicina Interna II, Dipartimento di Scienze Cliniche L Sacco, Ospedale L Sacco, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 7:e44553. 2012
    ..Major bleeding was the primary end point...
  64. ncbi request reprint Expression of endothelial protein C receptor and thrombomodulin in the intestinal tissue of patients with inflammatory bowel disease
    Elena M Faioni
    Hematology and Thrombosis Unit, Ospedale San Paolo
    Crit Care Med 32:S266-70. 2004
    ..The soluble forms of the receptors in plasma were measured...
  65. doi request reprint Determination of vitamin K1 in plasma by solid phase extraction and HPLC with fluorescence detection
    Rita Paroni
    Department of Medicine, Surgery and Dentistry, University of Milan, Milan, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 877:351-4. 2009
    ..This method, easy-to-handle and with a high throughput, can be used to identify covert states of vitamin K intake deficiency in patients thus at risk of alterations in blood clotting or bone mineralization...
  66. doi request reprint Clearance of circulating activated platelets in polycythemia vera and essential thrombocythemia
    Norma Maugeri
    Unit of Autoimmunity and Vascular Inflammation, Division of Regenerative Medicine, Gene Therapy and Stem Cells, Istituto Scientifico San Raffaele and Universita Vita Salute San Raffaele, Milan, Italy
    Blood 118:3359-66. 2011
    ....
  67. ncbi request reprint The pathogenesis of bladder detrusor endometriosis
    Paolo Vercellini
    First Department of Obstetrics and Gynecology, University of Milano, Italy
    Am J Obstet Gynecol 187:538-42. 2002
    ....
  68. ncbi request reprint Changes of prothrombin fragment 1+2 (F 1+2) as a function of increasing intensity of oral anticoagulation--considerations on the suitability of F 1+2 to monitor oral anticoagulant treatment
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Institute of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Haemost 79:571-3. 1998
    ..0. Since the risk of bleeding increases at INR greater than 4.5, our results suggest that F 1+2 is of little value to assess the hemorrhagic risk in patients on OAT...
  69. ncbi request reprint Multicenter study of homocysteine measurement--performance characteristics of different methods, influence of standards on interlaboratory agreement of results
    A Tripodi
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Department of Internal Medicine, University and IRCCS Maggiore Hospital, Milano, Italy
    Thromb Haemost 85:291-5. 2001
    ..Between-lab comparability of results is still a problem. The establishment of an international plasma standard would be of help to harmonize tHcy measurement across laboratories...
  70. doi request reprint Rare bleeding disorders
    F Peyvandi
    A Bianchi Bonomi Hemophilia and Thrombosis Center, Luigi Villa Foundation, IRCCS Maggiore Hospital, University of Milan, Milan, Italy
    Haemophilia 14:202-10. 2008
    ..Finally, the update of the Rare Bleeding Disorders Database will be presented by Dr Spreafico...
  71. ncbi request reprint Inhibition of the platelet P2Y12 receptor for adenosine diphosphate potentiates the antiplatelet effect of prostacyclin
    M Cattaneo
    Unita di Ematologia e Trombosi, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita di Milano, Milan, Italy
    J Thromb Haemost 5:577-82. 2007
    ..However, as P2Y(12) is negatively coupled to adenylyl cyclase (AC), its inhibition may also exert antithrombotic effects through the potentiation of prostacyclin (PGI(2)), which inhibit PA by stimulating AC...
  72. doi request reprint Pregnancy-related venous thromboembolism: risk and the effect of thromboprophylaxis
    Federico Lussana
    Divisione di Medicina Generale III, Azienda Ospedaliera San Paolo Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita degli Studi di Milano, Italy
    Thromb Res 129:673-80. 2012
    ..Balancing the absolute risk of VTE against the risks of exposure to anticoagulants, this review provides advice regarding which women may benefit from thromboprophylaxis during and after pregnancy...
  73. doi request reprint Association of V617F Jak2 mutation with the risk of thrombosis among patients with essential thrombocythaemia or idiopathic myelofibrosis: a systematic review
    Federico Lussana
    Divisione di Medicina Generale III, Azienda Ospedaliera San Paolo Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita di Milano, Via A Di Rudini 8, Milan, Italy
    Thromb Res 124:409-17. 2009
    ..Therefore, we performed a systematic review of the studies that assessed the risk of thrombosis associated with V617F Jak-2 in patients with ET or IM...
  74. ncbi request reprint New approaches for measuring coagulation
    T W Barrowcliffe
    Unita di Ematologia e Trombosi, Ospedale San Paolo, Universita di Milano, Italy
    Haemophilia 12:76-81. 2006
    ..Each test has advantages in various applications, but the thrombin generation test and waveform analysis have been found most useful in haemophilia, whilst the PFA-100 is helpful in von Willebrand's disease...
  75. ncbi request reprint Genetic risk factors for superficial vein thrombosis
    I Martinelli
    Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, IRCCS Maggiore Hospital, University of Milan, Italy
    Thromb Haemost 82:1215-7. 1999
    ..Hence, a laboratory search of these alterations is recommended in patients with SVT, because it allows the identification of patients at high risk of DVT in whom antithrombotic prophylaxis is particularly warranted...
  76. ncbi request reprint Is hyperhomocysteinemia an important risk factor of cardiovascular disease?
    Marco Cattaneo
    Unita di Ematologia e Trombosi, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita di Milano, Italy
    Pathophysiol Haemost Thromb 33:345-7. 2003
  77. ncbi request reprint Inherited platelet abnormalities
    M Cattaneo
    Unita di Ematologia e Trombosi, Ospedale San Paolo, Dipartimento di Medicina, Chirurgia e Odontoiatria, Universita di Milano, Italy
    Thromb Res 115:10-3. 2005
  78. ncbi request reprint Review of clinical, biochemical and genetic aspects of combined factor V and factor VIII deficiency, and report of a new affected family
    Elena M Faioni
    DMCO, University of Milano and Hematology and Thrombosis Unit, Ospedale San Paolo, Via A Di Rudini, 8, 20142 Milan, Italy
    Thromb Res 112:269-71. 2003
  79. ncbi request reprint Hyperhomocysteinemia: an important risk factor for cardiovascular disease? Potentially, yes
    M Cattaneo
    Unit of Hematology and Thrombosis, Department of Medicine, Surgery and Dentistry, University of Milan, Italy
    J Thromb Haemost 1:1878-9. 2003
  80. doi request reprint High-D-dimer plasma levels predict poor outcome in esophageal variceal bleeding
    M Primignani
    Gastroenterology 3 Unit, IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy
    Dig Liver Dis 40:874-81. 2008
    ..Since coagulation and fibrinolysis are abnormal in these patients we evaluated whether or not abnormalities of these haemostasis systems were independently related to mortality...
  81. pmc Tamoxifen reduces plasma homocysteine levels in healthy women
    M Cattaneo
    Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, IRCCS Ospedale Maggiore, Institute of Internal Medicine, University of Milano, Milan, Italy
    Br J Cancer 77:2264-6. 1998
    ..In conclusion, tamoxifen (20 mg day(-1) for 6 months) decreased plasma tHcy levels in healthy women. This effect may contribute to its protective effect on myocardial infarction...
  82. ncbi request reprint Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: phosphate substitution leads to multiple pathways of inhibition of platelet aggregation
    Bin Xu
    Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0810, USA
    J Med Chem 45:5694-709. 2002
    ..Thus, different substitution of the same nucleoside scaffold can target either of two P2Y receptors in platelets...
  83. ncbi request reprint Protease-activated receptors 1 and 4 do not stimulate G(i) signaling pathways in the absence of secreted ADP and cause human platelet aggregation independently of G(i) signaling
    Soochong Kim
    Department of Physiology and the Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 99:3629-36. 2002
    ....
  84. ncbi request reprint Inherited thrombocytopenias: a proposed diagnostic algorithm from the Italian Gruppo di Studio delle Piastrine
    Carlo L Balduini
    Dipartimento di Medicina Interna, IRCCS Policlinico San Matteo, Universita di Pavia, Italy
    Haematologica 88:582-92. 2003
    ..However, diagnosis of these disorders is often difficult and requires competences that are limited to specialized centers. We, therefore, suspect that inherited thrombocytopenias are underreported because their diagnosis is often missed...
  85. pmc A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo
    Beatrice Hechler
    Institut National de la Santé et de la Recherche Médicale INSERM U 311, EFS Alsace 10, rue Spielmann, BP No 36, 67065 Strasbourg Cedex, France
    J Exp Med 198:661-7. 2003
    ..Overall, the P2X1 receptor appears to contribute to the formation of platelet thrombi, particularly in arteries in which shear forces are high...
  86. ncbi request reprint Both vitamin B6 and total homocysteine plasma levels predict long-term atherothrombotic events in healthy subjects
    Diego Vanuzzo
    Cardiovascular Prevention Center, ASS 4 and Agenzia Regionale della Sanità del Friuli Venezia Giulia, Udine, Italy
    Eur Heart J 28:484-91. 2007
    ..We assessed the predictive value of total homocysteine (tHcy), vitamin B12, folate, and vitamin B6 on the long-term occurrence of coronary and cerebral atherothrombotic events in a nested case-control study...
  87. ncbi request reprint Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin
    Paolo Lova
    Center of Excellence in Applied Biology, Department of Biochemistry, University of Pavia, via Bassi 21, 27100 Pavia
    J Biol Chem 279:25299-306. 2004
    ..These results indicate that although both PAR-1 and PAR-4 signal Rap1B activation, the ability of thrombin to activate this GTPase independently of secreted ADP involves costimulation of both receptors as well as binding to GPIb-IX-V...
  88. ncbi request reprint The P2 receptors in platelet function
    Beatrice Hechler
    INSERM, Etablissement Francais du Sang Alsace, 10 rue Spielmann, BP 36 67065 Strasbourg Cedex, France
    Semin Thromb Hemost 31:150-61. 2005
    ..As such, they represent potential targets for antithrombotic drugs...
  89. ncbi request reprint Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial
    Martin den Heijer
    Department of Endocrinology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Blood 109:139-44. 2007
    ..65-1.98) in the hyperhomocysteinemic group and 0.58 (95% CI, 0.31-1.07) in the normohomocysteinemic group. The results of our study do not show that homocysteine lowering by B vitamin supplementation prevents recurrent venous thrombosis...
  90. pmc Rapid stimulation of tyrosine phosphorylation signals downstream of G-protein-coupled receptors for thromboxane A2 in human platelets
    Pietro Minuz
    Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
    Biochem J 400:127-34. 2006
    ..These findings suggest that both tyrosine phosphorylation and the Rho/Rho-kinase pathway are required to activate platelet aggregation via G(12/13) plus G(z) signalling...
  91. ncbi request reprint Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfon
    Beatrice Hechler
    INSERM U 311, Etablissement Francais du Sang Alsace, 10, rue Spielmann, Strasbourg Cedex, France
    J Pharmacol Exp Ther 314:232-43. 2005
    ..Overall, our results indicate that NF449 constitutes a new tool to investigate the functions of the P2X1 receptor and could be a starting compound in the search for new antithrombotic drugs targeting the platelet P2 receptors...
  92. ncbi request reprint Effects of 5'-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors
    Gloria Cristalli
    Dipartimento di Scienze Chimiche, Universita di Camerino, 62032 Camerino, Italy
    J Med Chem 48:2763-6. 2005
    ..On the contrary, the corresponding 2-phenylethynyladenosine di- (6) and triphosphate (8) did not induce platelet shape change or aggregation, but inhibited platelet aggregation induced by ADP...
  93. ncbi request reprint P2Y12 receptor antagonists: a rapidly expanding group of antiplatelet agents
    Marco Cattaneo
    Eur Heart J 27:1010-2. 2006
  94. pmc MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice
    Beatrice Hechler
    Institut National de la Sante et de la Recherche Medicale, U311, Strasbourg, France
    J Pharmacol Exp Ther 316:556-63. 2006
    ..These results add further evidence for a role of the P2Y(1) receptor in thrombosis and validate the concept that targeting the P2Y(1) receptor could be a relevant alternative or complement to current antiplatelet strategies...
  95. ncbi request reprint Adenosine diphosphate(ADP) does not induce thromboxane A2 generation in human platelets
    Marco Cattaneo
    Blood 99:3868-9; author reply 3869-70. 2002
  96. pmc A prototypic platelet septin and its participation in secretion
    Judith Dent
    Division of Experimental Hemostasis and Thrombosis, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:3064-9. 2002
    ..These results provide new insights into the mechanisms regulating platelet secretion and identify platelet septins as a protein family contributing to membrane trafficking within the megakaryocyte and platelet...
  97. ncbi request reprint Desmopressin in the treatment of patients with defects of platelet function
    Marco Cattaneo
    Haematologica 87:1122-4. 2002
  98. ncbi request reprint No effect of fasting plasma total homocysteine on protein C activity in vitro
    GianMarco Podda
    Blood 101:2446-7. 2003
  99. ncbi request reprint Homocysteine and the risk of intrauterine growth retardation
    Marco Cattaneo
    Clin Chem 49:1432-3. 2003
  100. ncbi request reprint Association of estrogen receptor-alpha genepolymorphisms with venous thrombosis
    Federico Lussana
    Haematologica 91:279-80. 2006
    ..We studied the distribution of ERalpha polymorphisms in patients with deep vein thrombosis. PvuII PP and XbaI XX genotypes may be associated with an approximately 2-fold increased DVT risk of deep vein thrombosis in men...