Elena Cattaneo

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. pmc Brain-derived neurotrophic factor in patients with Huntington's disease
    Chiara Zuccato
    Department of Pharmacological Sciences and Center for Stem Cell Research, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 6:e22966. 2011
  2. pmc Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates
    Alessia Garavaglia
    Dialectica S r l, c o Nerviano Medical Sciences, V le Pasteur 10, 20014 Nerviano MI, Italy
    BMC Neurosci 11:7. 2010
  3. pmc Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis
    Elisa Fossale
    Molecular Neurogenetics Unit of Department of Neurology and Center for Human Genetic Research, Massachusetts General Hospital, Charlestown, MA, USA
    BMC Neurosci 5:57. 2004
  4. pmc Characterization, developmental expression and evolutionary features of the huntingtin gene in the amphioxus Branchiostoma floridae
    Simona Candiani
    Department of Biology, University of Genoa, Viale Benedetto XV 5, 16132, Genoa, Italy
    BMC Dev Biol 7:127. 2007
  5. ncbi request reprint Normal huntingtin function: an alternative approach to Huntington's disease
    Elena Cattaneo
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    Nat Rev Neurosci 6:919-30. 2005
  6. ncbi request reprint Loss of normal huntingtin function: new developments in Huntington's disease research
    E Cattaneo
    Institute of Pharmacological Sciences, Universita di Milano, Via Balzaretti 9, 20133 Milano, Italy
    Trends Neurosci 24:182-8. 2001
  7. ncbi request reprint Chromatin dysfunction in Huntington's disease
    Elena Cattaneo
    Centre for Stem Cell Research and Department of Pharmacological Science, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Prog Neurobiol 83:193-4. 2007
  8. ncbi request reprint Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease
    Chiara Zuccato
    Department of Pharmacological Sciences and Centre for Stem Cell Research, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    J Neurosci 27:6972-83. 2007
  9. doi request reprint Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death
    Paola Conforti
    Center for Stem Cell Research, Universita degli Studi di Milano, Via Balzaretti 9, 20113 Milan, Italy
    Neurobiol Dis 50:160-70. 2013
  10. doi request reprint An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin
    Valentina Lo Sardo
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Universita degli Studi di Milano, Milano, Italy
    Nat Neurosci 15:713-21. 2012

Detail Information

Publications102 found, 100 shown here

  1. pmc Brain-derived neurotrophic factor in patients with Huntington's disease
    Chiara Zuccato
    Department of Pharmacological Sciences and Center for Stem Cell Research, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 6:e22966. 2011
    ..We also wish to warn the scientific community in interpreting the significance of changes measured in BDNF protein levels in serum from patients suffering from different conditions...
  2. pmc Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates
    Alessia Garavaglia
    Dialectica S r l, c o Nerviano Medical Sciences, V le Pasteur 10, 20014 Nerviano MI, Italy
    BMC Neurosci 11:7. 2010
    ..NS (Neural Stem) cells are a novel population of stem cells that undergo symmetric cell division in monolayer and chemically defined media, while remaining highly neurogenic...
  3. pmc Membrane trafficking and mitochondrial abnormalities precede subunit c deposition in a cerebellar cell model of juvenile neuronal ceroid lipofuscinosis
    Elisa Fossale
    Molecular Neurogenetics Unit of Department of Neurology and Center for Human Genetic Research, Massachusetts General Hospital, Charlestown, MA, USA
    BMC Neurosci 5:57. 2004
    ..We previously generated Cln3Deltaex7/8 knock-in mice, which replicate the common JNCL mutation, express mutant battenin and display JNCL-like pathology...
  4. pmc Characterization, developmental expression and evolutionary features of the huntingtin gene in the amphioxus Branchiostoma floridae
    Simona Candiani
    Department of Biology, University of Genoa, Viale Benedetto XV 5, 16132, Genoa, Italy
    BMC Dev Biol 7:127. 2007
    ..In the present paper the amphioxus general term must be referred to Branchiostoma floridae...
  5. ncbi request reprint Normal huntingtin function: an alternative approach to Huntington's disease
    Elena Cattaneo
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    Nat Rev Neurosci 6:919-30. 2005
    ....
  6. ncbi request reprint Loss of normal huntingtin function: new developments in Huntington's disease research
    E Cattaneo
    Institute of Pharmacological Sciences, Universita di Milano, Via Balzaretti 9, 20133 Milano, Italy
    Trends Neurosci 24:182-8. 2001
    ..Thus, complete elucidation of the physiological role(s) of huntingtin and its mode of action are essential and could lead to new therapeutic approaches...
  7. ncbi request reprint Chromatin dysfunction in Huntington's disease
    Elena Cattaneo
    Centre for Stem Cell Research and Department of Pharmacological Science, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Prog Neurobiol 83:193-4. 2007
  8. ncbi request reprint Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease
    Chiara Zuccato
    Department of Pharmacological Sciences and Centre for Stem Cell Research, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    J Neurosci 27:6972-83. 2007
    ..Finally, we show that attenuation of REST/NRSF binding restores BDNF levels, suggesting that relief of REST/NRSF mediated repression can restore aberrant neuronal gene transcription in HD...
  9. doi request reprint Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death
    Paola Conforti
    Center for Stem Cell Research, Universita degli Studi di Milano, Via Balzaretti 9, 20113 Milan, Italy
    Neurobiol Dis 50:160-70. 2013
    ..We concluded that Hdh CAG knock-in and Hdh knock-out NS cells have potential as tools for investigating the roles of normal and mutant HTT in differentiated neurons and glial cells of the brain...
  10. doi request reprint An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin
    Valentina Lo Sardo
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Universita degli Studi di Milano, Milano, Italy
    Nat Neurosci 15:713-21. 2012
    ....
  11. doi request reprint Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models
    Paola Conforti
    Department of Biosciences, Universita degli Studi di Milano, Milano, Italy Center for Stem Cell Research, Universita degli Studi di Milano, Milano, Italy
    J Neurochem 127:22-35. 2013
    ..Thus, a combination of virtual screening and biological approaches can lead to compounds reducing REST complex formation, which may be useful in HD and in other pathological conditions...
  12. ncbi request reprint Loss of huntingtin function complemented by small molecules acting as repressor element 1/neuron restrictive silencer element silencer modulators
    Dorotea Rigamonti
    Centre for Stem Cell Research and Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan 20133, Italy
    J Biol Chem 282:24554-62. 2007
    ....
  13. ncbi request reprint Progressive dysfunction of the cholesterol biosynthesis pathway in the R6/2 mouse model of Huntington's disease
    Marta Valenza
    Department of Pharmacological Sciences and Centre for Stem Cell Research, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Neurobiol Dis 28:133-42. 2007
    ..The defect occurs early in these mice and generates lower levels of newly synthesized cholesterol and its intermediates, which may affect different aspects of the disease...
  14. doi request reprint Human pluripotent stem cell differentiation into authentic striatal projection neurons
    Alessia Delli Carri
    Department of Biosciences and Center for Stem Cell Research, Universita degli Studi di Milano, 20133 Milan, Italy
    Stem Cell Rev 9:461-74. 2013
    ..Altogether this protocol defines a useful platform for in vitro developmental neurobiology studies, drug screening, and regenerative medicine approaches...
  15. ncbi request reprint Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons
    Alessia Delli Carri
    Center for Stem Cell Research, Universita degli Studi di Milano, 20133 Milan, Italy
    Development 140:301-12. 2013
    ....
  16. doi request reprint Analysis of the repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy of non-neuronal genes in peripheral lymphocytes from patients with Huntington's disease
    Manuela Marullo
    Department of Pharmacological Sciences and Center for Stem Cell Research, University of Milan, Milan, Italy
    Brain Pathol 20:96-105. 2010
    ..Chromatin immunoprecipitation (ChIP) of the RE1/NRSE sites in lymphocytes may therefore be a reproducible, sensitive and specific means of searching for candidate markers of HD onset and progression...
  17. ncbi request reprint Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
    Chiara Zuccato
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Nat Genet 35:76-83. 2003
    ..These data identify a new mechanism by which mutation of huntingtin causes loss of transcription of neuronal genes...
  18. ncbi request reprint The function of the neuronal proteins Shc and huntingtin in stem cells and neurons: pharmacologic exploitation for human brain diseases
    Chiara Zuccato
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Ann N Y Acad Sci 1049:39-50. 2005
    ....
  19. ncbi request reprint Systematic chromosomal analysis of cultured mouse neural stem cell lines
    Giuseppe R Diaferia
    Department of Functional Biology, BioRep, Milan, Italy
    Stem Cells Dev 20:1411-23. 2011
    ..Although chromosomal aberrations are known to occur less frequently in human cells, studies performed on murine stem cells provide an important complement to understand the biological events occurring in human lines...
  20. ncbi request reprint Progressive loss of BDNF in a mouse model of Huntington's disease and rescue by BDNF delivery
    Chiara Zuccato
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Pharmacol Res 52:133-9. 2005
    ..On this basis, we also discuss the possibility that delivery of BDNF may represent an useful strategy for Huntington's disease treatment...
  21. pmc Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes
    Marta Valenza
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Universita degli Studi di Milano, 20133 Milan, Italy
    J Neurosci 30:10844-50. 2010
    ..These findings indicate that cholesterol defect is robustly marked in HD animals, implying that strategies aimed at selectively modulating brain cholesterol metabolism might be of therapeutic significance...
  22. ncbi request reprint Phylogenetic comparison of huntingtin homologues reveals the appearance of a primitive polyQ in sea urchin
    Marzia Tartari
    Department of Pharmacological Sciences, University of Milan, Milano, Italy
    Mol Biol Evol 25:330-8. 2008
    ....
  23. ncbi request reprint Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease
    Marta Valenza
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
    J Neurosci 25:9932-9. 2005
    ..We conclude that the cholesterol biosynthetic pathway is impaired in HD cells, mice, and human subjects, and that the search for HD therapies should also consider cholesterol levels as both a potential target and disease biomarker...
  24. ncbi request reprint Neural stem cell systems: diversities and properties after transplantation in animal models of diseases
    Luciano Conti
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Milano, Italy
    Brain Pathol 16:143-54. 2006
    ..Our aim is to review the available information on the grafting of different NSC types into the adult rodent brain, focusing on critical aspects for the development of clinical therapies to replace damaged neurons...
  25. doi request reprint Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease
    Valerio Leoni
    Unit Biochemistry and Genetics, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy
    Brain 131:2851-9. 2008
    ..We conclude that that 24OHC levels complement MRI morphometry as a valuable tool to follow neurodegenerative changes in the early stages of Huntington disease...
  26. doi request reprint Emerging roles for cholesterol in Huntington's disease
    Marta Valenza
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Universita degli Studi di Milano, Milan, Italy
    Trends Neurosci 34:474-86. 2011
    ..A better understanding of how alterations in cholesterol levels contribute to the pathophysiology of HD is likely to have significant therapeutic implications for the treatment of this debilitating neurodegenerative disorder...
  27. doi request reprint Induced pluripotent stem cell lines from Huntington's disease mice undergo neuronal differentiation while showing alterations in the lysosomal pathway
    Valentina Castiglioni
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Universita degli Studi di Milano, Via Balzaretti 9 20133 Milano, Italy
    Neurobiol Dis 46:30-40. 2012
    ..More studies will be necessary to transform a revolutionary technology into a powerful platform for drug screening approaches...
  28. ncbi request reprint Molecular mechanisms and potential therapeutical targets in Huntington's disease
    Chiara Zuccato
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Universita degli Studi di Milano, Milan, Italy
    Physiol Rev 90:905-81. 2010
    ....
  29. ncbi request reprint Prevention of cytosolic IAPs degradation: a potential pharmacological target in Huntington's Disease
    Donato Goffredo
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Pharmacol Res 52:140-50. 2005
    ..Treatment with ucf101, a serine protease HTRA2 specific inhibitor, counteracts IAPs degradation in HD cells and increases their survival. These results point to the IAPs as potential pharmacological targets in Huntington's Disease...
  30. ncbi request reprint Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347
    Paola Conforti
    Department of Pharmacological Sciences and Center for Stem Cell Research, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    Mol Cell Neurosci 39:1-7. 2008
    ..Our results indicate that alterations in BDNF mRNA levels in peripheral blood are a readily accessible measurement of disease progression and drug efficacy in HD rodent models...
  31. doi request reprint Novel and immortalization-based protocols for the generation of neural CNS stem cell lines for gene therapy approaches
    Luciano Conti
    Department of Pharmacological Sciences and Center for Stem Cell Research, University of Milan, Milan, Italy
    Methods Mol Biol 438:319-32. 2008
    ..Furthermore, we describe the use of retroviral particles for genetic engineering...
  32. ncbi request reprint Early transcriptional profiles in huntingtin-inducible striatal cells by microarray analyses
    Simonetta Sipione
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Hum Mol Genet 11:1953-65. 2002
    ..Interestingly, this study revealed differential expression of a number of genes involved in cholesterol and fatty acid metabolism, suggesting that these metabolic pathways may play a role in HD pathogenesis...
  33. pmc REST controls self-renewal and tumorigenic competence of human glioblastoma cells
    Luciano Conti
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Universita degli Studi di Milano, Milano, Italy
    PLoS ONE 7:e38486. 2012
    ....
  34. pmc mSEL-1L (Suppressor/enhancer Lin12-like) protein levels influence murine neural stem cell self-renewal and lineage commitment
    Marina Cardano
    Doctorate School of Molecular Medicine, Universita degli Studi di Milano, 20100 Milan, Italy
    J Biol Chem 286:18708-19. 2011
    ..The results reported here denote mSEL-1L as a primitive marker with a possible involvement in the regulation of neural progenitor stemness maintenance and lineage determination...
  35. ncbi request reprint Turning REST/NRSF dysfunction in Huntington's disease into a pharmaceutical target
    Dorotea Rigamonti
    Universita degli Studi di Milano, Dipartimento di Scienze Farmacologiche e Centro di Ricerca sulle Cellule Staminali, Via Balzaretti 9, 20133 Milano
    Curr Pharm Des 15:3958-67. 2009
    ....
  36. ncbi request reprint From target identification to drug screening assays for neurodegenerative diseases
    Chiara Zuccato
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Pharmacol Res 52:245-51. 2005
    ..In this scenario, we present the case of a newly discovered molecular mechanism that may be of interest for drug discovery programmes in Huntington's disease and other neurodegenerative diseases...
  37. pmc Expressed Alu repeats as a novel, reliable tool for normalization of real-time quantitative RT-PCR data
    Manuela Marullo
    Department of Pharmacological Sciences and Center for Stem Cell Research, University of Milan, 9 Via Balzaretti, Milan, 20133, Italy
    Genome Biol 11:R9. 2010
    ..This result is particularly important for clinical diagnosis and biomarker validation studies based on mRNA detection in human blood...
  38. ncbi request reprint Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease
    Chiara Zuccato
    Department of Pharmacological Sciences and Center for Stem Cell Research, University of Milan, Milan, Italy
    Brain Pathol 18:225-38. 2008
    ..This indicates that, in addition to the reduction in BDNF mRNA, there is also unbalanced neurotrophic receptor signaling in HD...
  39. ncbi request reprint Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation
    Marta Valenza
    Department of Pharmacological Sciences, University of Milan, Italy
    Hum Mol Genet 16:2187-98. 2007
    ....
  40. doi request reprint Preservation of positional identity in fetus-derived neural stem (NS) cells from different mouse central nervous system compartments
    Marco Onorati
    Department of Pharmacological Sciences and Center for Stem Cell Research, Universita degli Studi di Milano, Via Balzaretti 9, 20133, Milan, Italy
    Cell Mol Life Sci 68:1769-83. 2011
    ..We also showed that traits of this positional code are maintained during neuronal differentiation, leading to the generation of electrophysiologically active neurons, even if they do not acquire a complete neurochemical identity...
  41. doi request reprint SAR and QSAR study on 2-aminothiazole derivatives, modulators of transcriptional repression in Huntington's disease
    Samantha Leone
    Istituto di Chimica Organica Alessandro Marchesini, Facolta di Farmacia, Universita degli Studi di Milano, via Venezian 21, 20133 Milano, Italy
    Bioorg Med Chem 16:5695-703. 2008
    ..A quantitative structure-activity relationship analysis performed using the Phase strategy yielded highly predictive 3D-QSAR pharmacophore model for in silico drug screening...
  42. ncbi request reprint Modeling brain pathologies using neural stem cells
    Simonetta Sipione
    Department of Pharmacological Sciences, National Center for Excellence on Neurodegenerative Disorders, Universita di Milano, 20133 Milan, Italy
    Methods Mol Biol 198:245-62. 2002
  43. ncbi request reprint The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity
    Stefano Camnasio
    Department of Pharmacological Sciences and Centre for Stem Cell Research, University of Milan, Milan, Italy
    Neurobiol Dis 46:41-51. 2012
    ..The CAG stability and lysosomal activity represent novel observations in HD-iPS cells. In the future, these cells may provide the basis for a powerful platform for drug screening and target identification in HD...
  44. doi request reprint Neuropotent self-renewing neural stem (NS) cells derived from mouse induced pluripotent stem (iPS) cells
    Marco Onorati
    Universita degli Studi di Milano, Department of Pharmacological Sciences and Centre for Stem Cell Research, 20133 Milano, Italy
    Mol Cell Neurosci 43:287-95. 2010
    ..Comparative studies between NS cells derived from iPS cells, reprogrammed from different somatic sources, and from authentic ES cells are necessary to identify critical elements for multipotency acquisition...
  45. ncbi request reprint Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons
    Donato Goffredo
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milano, Italy
    J Biol Chem 277:39594-8. 2002
    ..This cleavage could be prevented by calcium chelators and calpain inhibitors. Degradation of wild-type huntingtin by calcium-dependent proteases thus occurs in HD neurons, leading to loss of wild-type huntingtin neuroprotective activity...
  46. ncbi request reprint Neural stem and progenitor cells: choosing the right Shc
    Tiziana Cataudella
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, I 20133 Milan, Italy
    Prog Brain Res 146:127-33. 2004
    ..Here we will discuss values and unsolved aspects of the system and the employment of potentially key molecular targets for proper control of NSCs fate...
  47. ncbi request reprint Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington disease
    Alessia Tarditi
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Neurobiol Dis 23:44-53. 2006
    ..These data, reproducing ex vivo the previous observations in vitro, support the hypothesis that an alteration of A2A receptor signaling is present in HD and might represent an interesting target for neuroprotective therapies...
  48. doi request reprint Neural stem cells engrafted in the adult brain fuse with endogenous neurons
    Elisa Brilli
    Centre for Stem Cell Research, Universita degli Studi di Milano, Milano, Italy
    Stem Cells Dev 22:538-47. 2013
    ..The frequent and cell type-specific fusion of donor NSCs with host neurons highlights a previously underestimated biological property of the nervous tissue that might prove profitable for basic and therapeutically oriented studies...
  49. pmc Pitfalls in the detection of cholesterol in Huntington's disease models
    Manuela Marullo
    Centre for Stem Cell Research, Universita degli Studi di Milano, 20133 Milan, Italy
    PLoS Curr 4:e505886e9a1968. 2012
    ..Correspondence should be addressed to Elena Cattaneo: elena.cattaneo@unimi.it.
  50. ncbi request reprint Neural stem cells: a pharmacological tool for brain diseases?
    Luciano Conti
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Pharmacol Res 47:289-97. 2003
    ..Here, we will review the recent advancements on the biology of brain stem cells and discuss the mechanisms and drugs regulating adult neurogenesis, aiming at better estimating the possible future applications of NSCs for brain repair...
  51. pmc Huntingtin gene evolution in Chordata and its peculiar features in the ascidian Ciona genus
    Carmela Gissi
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita di Milano, Milano, Italy
    BMC Genomics 7:288. 2006
    ....
  52. doi request reprint p66(ShcA) adaptor molecule accelerates ES cell neural induction
    Evangelia Papadimou
    Centre for Stem Cell Research and Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    Mol Cell Neurosci 41:74-84. 2009
    ..Similar effects are obtained in human ES cells over-expressing p66(ShcA). This study reveals a role for p66(ShcA) in the modulation of Wnt/beta-catenin pathway and in ES cell neuralization which is consistent between mouse and human...
  53. ncbi request reprint Novel neural stem cell systems
    Luciano Conti
    University of Milano, Department of Pharmacological Sciences and Center for Stem Cell Research, Via Balzaretti 9, 20133 Milano, Italy
    Expert Opin Biol Ther 8:153-60. 2008
    ....
  54. ncbi request reprint Controlling neural stem cell division within the adult subventricular zone: an APPealing job
    Luciano Conti
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milan, Italy
    Trends Neurosci 28:57-9. 2005
    ..This result opens the hypothesis that changes in the levels of sAPP could influence activity of the neurogenic regions of the adult brain in normal and pathological conditions...
  55. ncbi request reprint Modeling Huntington's disease in cells, flies, and mice
    S Sipione
    Department of Pharmacological Sciences, University of Milano, Center of Excellence on Neurodegenerative Diseases, Italy
    Mol Neurobiol 23:21-51. 2001
    ....
  56. ncbi request reprint Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
    C Zuccato
    Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Science 293:493-8. 2001
    ..This leads to insufficient neurotrophic support for striatal neurons, which then die. Restoring wild-type huntingtin activity and increasing BDNF production may be therapeutic approaches for treating HD...
  57. ncbi request reprint Role of brain-derived neurotrophic factor in Huntington's disease
    Chiara Zuccato
    Department of Pharmacological Sciences and Centre for Stem Cell Research, University of Milano, Via Balzaretti 9, 20133 Milan, Italy
    Prog Neurobiol 81:294-330. 2007
    ....
  58. ncbi request reprint Cholesterol dysfunction in neurodegenerative diseases: is Huntington's disease in the list?
    Marta Valenza
    Department of Pharmacological Sciences and Centre for Stem Cell Research, Via Balzaretti 9, 20133 Milano, Italy
    Prog Neurobiol 80:165-76. 2006
    ..In particular, we consider the available clinical, biological and molecular evidence indicating a potential dysregulation of cholesterol homeostasis in Huntington's disease...
  59. ncbi request reprint Variations in the levels of the JAK/STAT and ShcA proteins in human brain tumors
    E Cattaneo
    Institute of Pharmacological Sciences, University of Milano, Italy
    Anticancer Res 18:2381-7. 1998
    ..Recent demonstrations that the JAK/STAT and ShcA signalling proteins are abundant in the developing CNS at the stage of maximal cell proliferation prompted us to determine whether these proteins were expressed in various human brain tumors...
  60. ncbi request reprint Generation and characterization of embryonic striatal conditionally immortalized ST14A cells
    E Cattaneo
    Institute of Pharmacological Sciences, University of Milano, Italy
    J Neurosci Res 53:223-34. 1998
    ..Furthermore, we analyzed the expression of specific growth factors and growth factor receptors in the ST14A cells, and found that nerve growth factor (NGF) and Trk receptors are most commonly expressed...
  61. ncbi request reprint Upregulation and activation of Stat6 precede vascular smooth muscle cell proliferation in carotid artery injury model
    R Baetta
    Institute of Pharmacological Sciences, University of Milan, Milan, Italy
    Arterioscler Thromb Vasc Biol 20:931-9. 2000
    ..These data indicate that Stat6 signaling may contribute to the modifications of gene expression underlying VSMC activation in the context of acute vascular proliferative diseases...
  62. ncbi request reprint Executive dysfunction and avoidant personality trait in myotonic dystrophy type 1 (DM-1) and in proximal myotonic myopathy (PROMM/DM-2)
    G Meola
    Department of Neurology, University of Milan, San Donato Hospital, Via Morandi 30, San Donato Milanese, 20097 Milan, Italy
    Neuromuscul Disord 13:813-21. 2003
    ..The results suggest that there is a specific cognitive and behavioural profile in PROMM/DM-2 and in DM-1, and that this profile is associated with hypoperfusion in frontal and parieto-occipital regions of the brain...
  63. ncbi request reprint Non-virally mediated gene transfer into human central nervous system precursor cells
    E Cattaneo
    Institute of Pharmacological Sciences, University of Milan, Italy
    Brain Res Mol Brain Res 42:161-6. 1996
    ..Colonies of Large-T antigen immunoreactive cells were indeed visible 10 days after transfection...
  64. ncbi request reprint Dysfunction of wild-type huntingtin in Huntington disease
    Elena Cattaneo
    Department of Pharmacological Sciences and Center for Excellence in Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
    News Physiol Sci 18:34-7. 2003
    ..However, recent results indicate that wild-type huntingtin has important activities in brain neurons, suggesting that loss of these activities may play a role in HD...
  65. doi request reprint Neural stem cell systems: physiological players or in vitro entities?
    Luciano Conti
    Department of Pharmacological Sciences and Center for Stem Cell Research, University of Milan, Via Balzaretti 9, Milan, Italy
    Nat Rev Neurosci 11:176-87. 2010
    ..A better understanding of these systems will be crucial to control NSC fate and functional integration following transplantation and to make NSCs suitable for regenerative efforts following injury or disease...
  66. doi request reprint Brain-derived neurotrophic factor in neurodegenerative diseases
    Chiara Zuccato
    Department of Pharmacological Sciences and Center for Stem Cell Research, University of Milan, Via Balzaretti 9, Milan, Italy
    Nat Rev Neurol 5:311-22. 2009
    ....
  67. doi request reprint Rescue of gene expression by modified REST decoy oligonucleotides in a cellular model of Huntington's disease
    Chiara Soldati
    Department of Neuroscience and Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King s College London, The James Black Centre, London, UK
    J Neurochem 116:415-25. 2011
    ..These data point to an alternative strategy for rebalancing the transcriptional dysregulation in HD...
  68. doi request reprint Wnt5a is a transcriptional target of Dlx homeogenes and promotes differentiation of interneuron progenitors in vitro and in vivo
    Sara Paina
    Dulbecco Telethon Institute c o Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy
    J Neurosci 31:2675-87. 2011
    ..Finally, we show that the Dlx-mutant environment is unfavorable for GABA differentiation, in vivo and in vitro. We conclude that Dlx genes favor interneuron differentiation also in a non-cell-autonomous fashion, via expression of Wnt5a...
  69. doi request reprint An optimized experimental strategy for efficient conversion of embryonic stem (ES)-derived mouse neural stem (NS) cells into a nearly homogeneous mature neuronal population
    D Spiliotopoulos
    Department of Pharmacological Sciences and Center for Stem Cell Research, University of Milan, Italy
    Neurobiol Dis 34:320-31. 2009
    ....
  70. doi request reprint Setting the conditions for efficient, robust and reproducible generation of functionally active neurons from adult subventricular zone-derived neural stem cells
    D Goffredo
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Cell Death Differ 15:1847-56. 2008
    ..Remarkably, the neuronal progeny carries a defined set of antigenic, biochemical and functional characteristics that make this system suitable for studies of NS cell biology as well as for genetic and chemical screenings...
  71. ncbi request reprint Shc signaling in differentiating neural progenitor cells
    L Conti
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Nat Neurosci 4:579-86. 2001
    ..We suggest that the switch from ShcA to ShcC modifies the responsiveness of neural stem/progenitor cells to extracellular stimuli, generating proliferation (with ShcA) or survival/differentiation (with ShcC)...
  72. doi request reprint Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells
    Roberto Papait
    Dialectica s r l V le Pasteur 10, 20014 Nerviano, Milan, Italy
    Biochem Biophys Res Commun 379:434-9. 2009
    ..We conclude that TMZ and BCNU efficacy in glioma treatment may implicate a first event characterized by changes in heterochromatin organization and its silencing which is then followed by apoptosis and senescence...
  73. ncbi request reprint Huntington's disease
    Chiara Zuccato
    Department of Biosciences and Centre for Stem cell Research, Universita degli Studi di Milano, via Viotti 3 5, 20133, Milan, Italy
    Handb Exp Pharmacol 220:357-409. 2014
    ..The experimental strategies under investigation to increase brain BDNF levels in animal models of HD will also be described, with a view to ultimately improving the clinical treatment of this condition. ..
  74. ncbi request reprint Gene therapy using neural stem cells
    Luciano Conti
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Methods Mol Biol 198:233-44. 2002
  75. ncbi request reprint Huntingtin's neuroprotective activity occurs via inhibition of procaspase-9 processing
    D Rigamonti
    Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    J Biol Chem 276:14545-8. 2001
    ..However, procaspase-9 is not processed, indicating that wild-type Htt (wtHtt) acts downstream of cytochrome c release. These data show that Htt inhibits neuronal cell death by interfering with the activity of the apoptosome complex...
  76. ncbi request reprint Freshly dissociated fetal neural stem/progenitor cells do not turn into blood
    Lorenzo Magrassi
    Neurochirurgia Dipartimento di Chirurgia, Universita di Pavia, IRCCS Policlinico S 27100, Matteo, Pavia, Italy
    Mol Cell Neurosci 22:179-87. 2003
    ..Our data indicate that ability to transdifferentiate from neural into the hematopoietic phenotype, if present, is acquired only after in vitro expansion of neural stem/progenitor cells and it is not present in vivo...
  77. ncbi request reprint Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy
    Vincenza Barresi
    Department of Chemical Sciences, University of Catania, Italy
    Cancer Gene Ther 10:396-402. 2003
    ..5-FC had no effect on the tumor in the absence of CD-expressing ST14A cells. Our results support the feasibility of systems based on intratumoral transplantation of prodrug-converting cells for brain tumor therapy...
  78. ncbi request reprint Ciliary neurotrophic factor overexpression in neural progenitor cells (ST14A) increases proliferation, metabolic activity, and resistance to stress during differentiation
    Sabine Weinelt
    Neurobiological Laboratory, Department of Neurology, University of Rostock, Rostock, Germany
    J Neurosci Res 71:228-36. 2003
    ....
  79. ncbi request reprint The enigma of Huntington's disease
    Elena Cattaneo
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan in Italy
    Sci Am 287:92-7. 2002
  80. ncbi request reprint Opinion: neural stem cell therapy for neurological diseases: dreams and reality
    Ferdinando Rossi
    Rita Levi Montalcini Center for Brain Repair, Department of Neuroscience, Section of Physiology, University of Turin, Corso Raffaello 30, 10125 Turin, Italy
    Nat Rev Neurosci 3:401-9. 2002
    ....
  81. ncbi request reprint Mutant huntingtin goes straight to the heart
    Elena Cattaneo
    Nat Neurosci 5:711-2. 2002
  82. ncbi request reprint Gene expression profiling of ciliary neurotrophic factor-overexpressing rat striatal progenitor cells (ST14A) indicates improved stress response during the early stage of differentiation
    Tobias Böttcher
    Department of Neurology, University of Rostock, Rostock, Germany
    J Neurosci Res 73:42-53. 2003
    ..g., of Huntington's disease...
  83. ncbi request reprint Do amniotic fluid-derived stem cells differentiate into neurons in vitro?
    Mauro Toselli
    Nat Biotechnol 26:269-70; author reply 270-1. 2008
  84. ncbi request reprint Selective inhibitors of death in mutant huntingtin cells
    Hemant Varma
    Department of Biological Sciences, Columbia University, Fairchild Center, MC 2406, 1212 Amsterdam Avenue, New York, New York 10027, USA
    Nat Chem Biol 3:99-100. 2007
    ..Four compounds were active in diverse HD models, which suggests a role for cell death in HD; these compounds are mechanistic probes and potential drug leads for HD...
  85. pmc Niche-independent symmetrical self-renewal of a mammalian tissue stem cell
    Luciano Conti
    Institute for Stem Cell Research, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 3:e283. 2005
    ..These homogenous cultures will enable delineation of molecular mechanisms that define a tissue-specific stem cell and allow direct comparison with pluripotent ES cells...
  86. ncbi request reprint Induction of GABAergic phenotype in a neural stem cell line for transplantation in an excitotoxic model of Huntington's disease
    Miquel Bosch
    Departament de Biologia Cellular i Anatomia Patologica, Facultat de Medicina, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, E 08036 Barcelona, Spain
    Exp Neurol 190:42-58. 2004
    ..These data may lend support to the possibility of cell replacement therapies for Huntington's disease using neural stem cells...
  87. ncbi request reprint ErbB4 expression in neural progenitor cells (ST14A) is necessary to mediate neuregulin-1beta1-induced migration
    Giovanna Gambarotta
    Department of Human and Animal Biology, University of Torino, Torino 10123, Italy
    J Biol Chem 279:48808-16. 2004
    ..Our data show that ErbB4 signaling via PI3K activation plays a fundamental role in controlling NRG1beta1-induced migration...
  88. ncbi request reprint Wnt-5a expression in the rat neuronal progenitor cell line ST14A
    Sabine Peters
    Department of Neurology, University of Rostock, PO Box 100888, 18055 Rostock, Germany
    Exp Brain Res 158:189-95. 2004
    ..However, they raise the possibility that neuronal progenitor cells that might be used to treat neurodegenerative diseases express Wnt-5a, thus promoting their potential for dopaminergic differentiation...
  89. ncbi request reprint Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture
    Yirui Sun
    Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Cambridge, UK
    Mol Cell Neurosci 38:245-58. 2008
    ..Human NS cells can be stably transfected to provide reporter lines and readily imaged in live monolayer cultures, creating the potential for high content genetic and chemical screens...
  90. ncbi request reprint SUMO modification of Huntingtin and Huntington's disease pathology
    Joan S Steffan
    Department of Psychiatry and Human Behavior, Gillespie 2121, University of California, Irvine, CA 92697, USA
    Science 304:100-4. 2004
    ..Lysine mutations that prevent both SUMOylation and ubiquitination of Httex1p reduce HD pathology, indicating that the contribution of SUMOylation to HD pathology extends beyond preventing Htt ubiquitination and degradation...
  91. ncbi request reprint Co-localization of brain-derived neurotrophic factor (BDNF) and wild-type huntingtin in normal and quinolinic acid-lesioned rat brain
    Francesca R Fusco
    Basal Ganglia Unit, Laboratory of Experimental Neurorehabilitation, Santa Lucia Foundation IRCCS, Via Ardeatina 306, Rome 00179, Italy
    Eur J Neurosci 18:1093-102. 2003
    ....
  92. ncbi request reprint CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice
    Barbara L Apostol
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697, USA
    Mol Cell Neurosci 39:8-20. 2008
    ..These studies suggest a novel therapeutic approach for a currently untreatable neurodegenerative disease, HD, via CEP-1347 up-regulation of BDNF...
  93. ncbi request reprint EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer
    Luke Hughes-Davies
    Cancer Research UK Wellcome Trust Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
    Cell 115:523-35. 2003
    ..The remarkable clinical overlap between sporadic EMSY amplification and familial BRCA2 deletion implicates a BRCA2 pathway in sporadic breast and ovarian cancer...
  94. ncbi request reprint Aberrant A2A receptor function in peripheral blood cells in Huntington's disease
    Katia Varani
    Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Italy
    FASEB J 17:2148-50. 2003
    ..Future studies will assess whether this parameter can be exploited as a peripheral biomarker of Huntington's disease...
  95. ncbi request reprint Depletion of wild-type huntingtin in mouse models of neurologic diseases
    Yu Zhang
    Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Neurochem 87:101-6. 2003
    ..We propose that in HD, in addition to a toxic gain-of-function of mutant huntingtin, a parallel depletion of wild-type huntingtin results in a detrimental loss-of-function, playing an important role in disease progression...
  96. ncbi request reprint No evidence of association between BDNF gene variants and age-at-onset of Huntington's disease
    Emilio Di Maria
    Department of Neuroscience, Ophthalmology and Genetics, Section of Medical Genetics, University of Genova, and Medical Genetics Unit, San Martino Hospital, Genova, Italy
    Neurobiol Dis 24:274-9. 2006
    ..Additional studies are warranted to further investigate BDNF as genetic modifier of the HD phenotype...
  97. ncbi request reprint A microRNA-based gene dysregulation pathway in Huntington's disease
    Rory Johnson
    Genome Institute of Singapore, 60 Biopolis Street, 02 01 Genome, Singapore 138672, Singapore
    Neurobiol Dis 29:438-45. 2008
    ....
  98. ncbi request reprint Shc3 affects human high-grade astrocytomas survival
    Lorenzo Magrassi
    Neurochirurgia, Dipartimento di Chirurgia, Universita di Pavia, IRCCS Policlinico S Matteo, and IGM CNR, P le Golgi 2, Pavia 27100, Italy
    Oncogene 24:5198-206. 2005
    ..These data suggest that Shc molecules play an important role in glioblastoma cell growth and survival...
  99. ncbi request reprint Calcium homeostasis and mitochondrial dysfunction in striatal neurons of Huntington disease
    Dmitry Lim
    Venetian Institute of Molecular Medicine, Via Orus 2, 35129 Padua, Italy
    J Biol Chem 283:5780-9. 2008
    ..The observed decrease of cell Ca2+ could be a compensatory attempt to prevent the Ca2+ stress that would irreversibly damage mitochondria and eventually lead to cell death...
  100. ncbi request reprint Severe deficiency of the fatty acid amide hydrolase (FAAH) activity segregates with the Huntington's disease mutation in peripheral lymphocytes
    Natalia Battista
    Department of Biomedical Sciences, University of Teramo, Piazza A Moro 45, Teramo, Italy
    Neurobiol Dis 27:108-16. 2007
    ....
  101. ncbi request reprint Evaluating test statistics to select interesting genes in microarray experiments
    Charles Kooperberg
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, PO Box 19024, MP 1002, Seattle, WA 98109 1024, USA
    Hum Mol Genet 11:2223-32. 2002
    ..A small simulation study compares the effectiveness of the proposed procedure with the significance analysis of microarrays (SAM) procedure...