Research Topics
Genomes and Genes | Alberico L CatapanoSummaryAffiliation: University of Milan Country: Italy Publications
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Publications
Combination therapy in cholesterol reduction: focus on ezetimibe and statinsLiliana Grigore
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Vasc Health Risk Manag 4:267-78. 2008....
Global cardiovascular risk : the role of plasma lipidsAlberico L Catapano
Department of Pharmacological Sciences, Director Center for the Study of Atherosclerosis, Marie Curie Training Centre for Cardiovascular Diseases, University of Milan, Via G Balzaretti 9 20133, Milan, Italy
High Blood Press Cardiovasc Prev 12:125-33. 2005..g. patients with previous myocardial infarction or stroke)...
Statin-induced myotoxicity: pharmacokinetic differences among statins and the risk of rhabdomyolysis, with particular reference to pitavastatinAlberico L Catapano
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Curr Vasc Pharmacol 10:257-67. 2012..Such differences in drug � drug interaction profiles among available statins offer the possibility of reducing the risk of myotoxicity among high-risk patients...- Averting a pandemic health crisis in Europe by 2020: what physicians need to know regarding cholesterol managementAlberico L Catapano
Centre for the Study of Atherosclerosis, Marie Curie Training Centre for Cardiovascular Diseases, University of Milan, Milan, Italy
Eur J Cardiovasc Prev Rehabil 14:340-5. 2007..According to a recent report by the Stockholm Network (an independent European 'think tank'), major political, economic, social, and medical changes are urgently needed with respect to cholesterol management to help prevent CVD... - Perspectives on low-density lipoprotein cholesterol goal achievementAlberico L Catapano
Marie Curie Training Centre for Cardiovascular Diseases, University of Milan, Milan, Italy
Curr Med Res Opin 25:431-47. 2009..European and US guidelines now recommend lower LDL-C levels, particularly in high-risk patients. Although LDL-C treatment goals to reduce the risk of CHD are clear, many patients do not reach their LDL-C goals... - Native LDL and oxidized LDL modulate cyclooxygenase-2 expression in HUVECs through a p38-MAPK, NF-kappaB, CRE dependent pathway and affect PGE2 synthesisG D Norata
Department of Pharmacological Sciences, University of Milan, Italy
Int J Mol Med 14:353-9. 2004.... - Low density lipoprotein oxidation, antioxidants, and atherosclerosisA L Catapano
Institute of Pharmacological Sciences, University of Milan, Italy
Curr Opin Cardiol 15:355-63. 2000..When it becomes possible to monitor the efficacy of any antioxidant therapy with validated markers of oxidation, the potential influence of vitamins and antioxidants on coronary artery disease will eventually be resolved... - Pitavastatin - pharmacological profile from early phase studiesAlberico L Catapano
Centre for the Study of Atherosclerosis, Department of Pharmacological Sciences, University of Milan, and IRCSS Multimedica, Sesto S Giovanni, Milan, Italy
Atheroscler Suppl 11:3-7. 2010..Consequently, pitavastatin has minimal drug-food and drug-drug interactions making it a treatment option in the large group of dyslipidaemic people that require multidrug therapy... - [Intestinal cholesterol absorption: a pharmacological target for lowering of plasma cholesterol]Alberico L Catapano
Dipartimento di Scienze Farmacologiche, Centro per lo Studio dell Aterosclerosi, Universita degli Studi, Milano
Ital Heart J Suppl 5:779-84. 2004.... - Lipid-altering efficacy of the ezetimibe/simvastatin single tablet versus rosuvastatin in hypercholesterolemic patientsAlberico L Catapano
University of Milan, Milan, Italy
Curr Med Res Opin 22:2041-53. 2006..To assess the lipid-altering efficacy and safety of ezetimibe/simvastatin single tablet product compared with rosuvastatin at the approved usual starting, next highest, and maximum doses... - The pharmacologic elegance of inhibiting cholesterol absorption and synthesis while providing a homeostatic balanceAlberico L Catapano
Center for the Study of Atherosclerosis and Laboratory of Lipoprotein Metabolism, Department of Pharmacological Sciences, University of Milan, Milan, Italy
Fundam Clin Pharmacol 21:21-6. 2007.... - Oxidized-HDL3 modulates the expression of Cox-2 in human endothelial cellsElisa Callegari
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Int J Mol Med 18:209-13. 2006..These data suggest that Ox-HDL induce Cox-2 expression in endothelial cells through a PI3K/NF-IL6-dependent pathway... - [Rosuvastatin: pharmacologic features]Franco Bernini
Dipartimento di Scienze Farmacologiche, Biologiche e Chimiche Applicate, Universita degli Studi, Campus Universiario, 43100 Parma
Ital Heart J 4:22S-32S. 2003..Rosuvastatin effectively decreases triglycerides, triglyceride-rich lipoproteins, non-HDL cholesterol, and increases HDL cholesterol. All together these properties will favor the achievement of therapeutic goals in the treated patients... - Oxidised-HDL3 induces the expression of PAI-1 in human endothelial cells. Role of p38MAPK activation and mRNA stabilizationGiuseppe D Norata
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Br J Haematol 127:97-104. 2004..In summary, Ox-HDL3 induced PAI-1 mRNA expression and antigen release through a molecular mechanism involving MAPK activation and mRNA stabilization. Thus, oxidative modification converts HDL to a prothrombotic lipoprotein species... - Modification of HDL3 by mild oxidative stress increases ATP-binding cassette transporter 1-mediated cholesterol effluxAngela Pirillo
Department of Pharmacological Sciences, Via Balzaretti, 9, 20133 Milano, Italy
Cardiovasc Res 75:566-74. 2007..In the present study we investigated the effect of a mild oxidation of HDL(3) on its function as cholesterol acceptor... - Cost-effectiveness of enhancing adherence to therapy with statins in the setting of primary cardiovascular prevention. Evidence from an empirical approach based on administrative databasesGiovanni Corrao
Department of Statistics, Unit of Biostatistics and Epidemiology, University of Milano Bicocca, Milan, Italy
Atherosclerosis 217:479-85. 2011..To estimate the cost-effectiveness of enhancing adherence to statin therapy across a large population without signs of pre-existing cardiovascular disease... - High-density lipoproteins induce transforming growth factor-beta2 expression in endothelial cellsGiuseppe D Norata
Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
Circulation 111:2805-11. 2005..In addition to its role in reverse cholesterol transport, HDL influences different functions of endothelial cells. In the present study, we investigated in endothelial cells the genes involved in inflammation modulated by HDL... - C-reactive protein distribution and correlation with traditional cardiovascular risk factors in the Italian populationManuela Casula
Epidemiology and Preventive Pharmacology Centre SEFAP, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
Eur J Intern Med 24:161-6. 2013..We report the distribution of plasma levels of CRP and its possible relationship with other cardiovascular risk factors in an Italian cohort... - Reaching LDL-c targets in high-risk patients requires high-efficacy cholesterol-lowering drugs in more than 50% of cases. The results of the CHECK studyAndrea Poli
SEFAP, University of Milan, Milan, Italy
Pharmacol Res 64:393-6. 2011..Our data might conceivably be applied to other low-cardiovascular risk countries and should be taken into account when defining the proportion of drugs with different efficacy and cost in the everyday clinical practice... - Endothelin-1 does not impair insulin-induced angiogenesis in vitroFabio Pellegatta
Laboratory of Lipid Metabolism, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, I 20132 Milan, Italy
Int J Mol Med 28:443-8. 2011..In the two in vitro models of angiogenesis, ET-1 did not inhibit insulin-induced angiogenesis. From these data we conclude that in vitro, at the times and at the concentrations examined, ET-1 does not impair insulin-induced angiogenesis... - Effect of treatment with pravastatin or ezetimibe on endothelial function in patients with moderate hypercholesterolemiaLiliana Grigore
Center for the Study of Atherosclerosis SISA Lombardia, Bassini Hospital, Via Gorki 50, 20092, Cinisello Balsamo, Milan, Italy
Eur J Clin Pharmacol 69:341-6. 2013.... - Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) by 15-lipoxygenase-modified LDL in endothelial cellsAngela Pirillo
Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
Atherosclerosis 214:331-7. 2011..Lectin-like oxidized LDL receptor-1 (LOX-1), the endothelial receptor for OxLDL, is believed to be responsible for a number of OxLDL-induced effects in the endothelium... 
Molecular mechanisms responsible for the antiinflammatory and protective effect of HDL on the endotheliumGiuseppe D Norata
Department of Pharmacological Sciences, University of Milan, Italy
Vasc Health Risk Manag 1:119-29. 2005....- Dual effect of hypochlorite in the modification of high density lipoproteinsAngela Pirillo
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Biochem Biophys Res Commun 403:447-51. 2010.... - HDLs, immunity, and atherosclerosisGiuseppe D Norata
Department of Pharmacological Sciences, Universita degli Studi di Milano, Centro SISA per lo Studio dell Aterosclerosi, Ospedale Bassini, Cinisello Balsamo, Milan, Italy
Curr Opin Lipidol 22:410-6. 2011..Among them, the most relevant is the ability of HDL to promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion... - High-density lipoprotein subfraction 3 decreases ADAMTS-1 expression induced by lipopolysaccharide and tumor necrosis factor-alpha in human endothelial cellsGiuseppe D Norata
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Matrix Biol 22:557-60. 2004..Since ADAMTS-1 has recently been shown to inhibit endothelial cell proliferation, the result of the present work may represent a new mechanism by which HDL could have a positive effect on endothelial cell and vascular wall function... - Improvement of endothelial function in uraemic patients on peritoneal dialysis: a possible role for 5-MTHF administrationIvano Baragetti
Department of Internal Medicine, Nephrology and Dialysis Unit, Bassini Hospital, Cinisello Balsamo, Milan, Italy
Nephrol Dial Transplant 22:3292-7. 2007..In patients with chronic renal failure, the administration of folic acid or its metabolites reduces but does not normalize plasma homocysteine concentrations... - Plasma resistin levels correlate with determinants of the metabolic syndromeG D Norata
Centro SISA per lo Studio della Aterosclerosi, Ospedale Bassini, Cinisello Balsamo, Milano, Italy
Eur J Endocrinol 156:279-84. 2007..The aim of the present study was to investigate the relationship of plasma resistin levels with markers of the metabolic syndrome and atherosclerosis in a large population-based study... - Plasma adiponectin levels in chronic kidney disease patients: relation with molecular inflammatory profile and metabolic statusG D Norata
Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133 Milan, Italy
Nutr Metab Cardiovasc Dis 20:56-63. 2010..Adiponectin (ADPN) exerts anti-inflammatory and cardio protective effects and is associated with decreased cardiovascular risk, however its role in patients with chronic kidney disease is unclear... - Gene expression and intracellular pathways involved in endothelial dysfunction induced by VLDL and oxidised VLDLG D Norata
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Cardiovasc Res 59:169-80. 2003..These findings confirm the involvement of VLDL and Ox-VLDL in endothelial dysfunction and suggest new genes and molecular mechanisms involved in these actions... - Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunctionG D Norata
Department of Pharmacological Sciences, University of Milan, Milan, Italy
J Intern Med 262:104-12. 2007..The aim of this study was to investigate the association of the -420C/G polymorphism with metabolic syndrome, obesity, myocardial infarction and kidney disease... - Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal ModelsEnrico Ammirati
Clinical Cardiovascular Biology Centre, San Raffaele Scientific Institute and the Università Vita Salute San Raffaele, Milan, Italy E A, D C, M B Heart Transplantation Division, Ospedale Niguarda Ca Granda, Milan, Italy E A Heart Care Foundation, Florence, Italy E A, A M
J Am Heart Assoc 1:27-41. 2012..J Am Heart Assoc. 2012;1:27-41.)... - Monitoring statin safety in primary careElena Tragni
Epidemiology and Preventive Pharmacology Center, Department of Pharmacological Sciences, University of Milan, Via Balzaretti, Milan, Italy
Pharmacoepidemiol Drug Saf 16:652-7. 2007..To verify General Practitioners (GPs) compliance to the recommended laboratory monitoring for statin users... - Results of a retrospective database analysis of adherence to statin therapy and risk of nonfatal ischemic heart disease in daily clinical practice in ItalyGiovanni Corrao
Department of Statistics, Unit of Biostatistics and Epidemiology, University of Milano Bicocca, Milan, Italy
Clin Ther 32:300-10. 2010..However, inadequate adherence may reduce statins' protective effects... - 15-Lipoxygenase-mediated modification of high-density lipoproteins impairs SR-BI- and ABCA1-dependent cholesterol efflux from macrophagesAngela Pirillo
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Biochim Biophys Acta 1761:292-300. 2006..These results suggest that 15-lipoxygenase might induce structural alterations of HDL3 particles that impair their capability of triggering reverse cholesterol transport... - 5-methyltetrahydrofolate restores endothelial function in uraemic patients on convective haemodialysisGherardo Buccianti
Department of Internal Medicine, Nephrology and Dialysis Unit, Bassini Hospital, Cinisello Balsamo, Milan, Italy
Nephrol Dial Transplant 17:857-64. 2002..Furthermore, homocysteine induces endothelial dysfunction by an increased inactivation of nitric oxide... - HDL3 induces cyclooxygenase-2 expression and prostacyclin release in human endothelial cells via a p38 MAPK/CRE-dependent pathway: effects on COX-2/PGI-synthase couplingG D Norata
Department of Pharmacological Sciences, University of Milan, Italy
Arterioscler Thromb Vasc Biol 24:871-7. 2004..The understanding of these mechanisms may provide new insights into the antiatherogenic role of HDL... - Increased atherosclerosis and vascular inflammation in APP transgenic mice with apolipoprotein E deficiencyG Tibolla
Department of Pharmacological Sciences, Universita degli Studi di Milano, 20133 Milan, Italy
Atherosclerosis 210:78-87. 2010..Aim of this study was to investigate aortic atherosclerosis development in a mouse model with central nervous system (CNS) restricted beta-amyloid precursor protein (APP) overexpression... - Statins and oxidative stress during atherogenesisGiuseppe D Norata
Department of Pharmacological Sciences, University of Milan, and Centro per lo Studio e la Prevenzione delle Vasculopatie Periferiche, Ospedale Bassini, Italy
J Cardiovasc Risk 10:181-9. 2003..Among their properties statins also possess antioxidant activities and the aim of this paper is to review the scientific evidence for such an effect and its possible clinical relevance... - Effect of the Toll-like receptor 4 (TLR-4) variants on intima-media thickness and monocyte-derived macrophage response to LPSG D Norata
Department of Pharmacological Sciences, University of Milan, Milan, Italy
J Intern Med 258:21-7. 2005..We have investigated whether the presence of the D299G polymorphism and the co-segregated T399I polymorphism affects the intima-media thickness (IMT) in the general population... - [Achievement of the therapeutic goals for dyslipidemia in clinical practice: results of a survey among general practice physicians from Lombardy]Elena Tragni
Servizio di Epidemiologia e Farmacologia Preventiva SEFAP, Dipartimento di Scienze Farmacologiche, Universita degli Studi, Via Balzaretti, 9 20133 Milano
Ital Heart J 4:47S-57S. 2003.... - Effects of HDL3 on the expression of matrix-degrading proteases in human endothelial cellsGiuseppe D Norata
Department of Pharmacological Sciences, University of Milan, Milan, Italy
Int J Mol Med 12:73-8. 2003..The expression pattern was confirmed by quantitative real-time PCR. In summary, a large repertoire of matrix-degrading proteases is expressed in endothelial cells, an expression that can be modulated by native and oxidized HDL3... - Effects of fractalkine receptor variants on common carotid artery intima-media thicknessGiuseppe D Norata
Department of Pharmacological Sciences, University of Milan, Italy
Stroke 37:1558-61. 2006..In the present study, we investigated the possible association between CX3CR1variants and intima-media thickness (IMT)... - Role of vitamin E-coated membrane in reducing advanced glycation end products in hemodialysis patients: a pilot studyI Baragetti
Department of Medicine, Division of Nephrology and Dialysis, Cinisello Balsamo, University of Milan, Milan, Italy
Blood Purif 24:369-76. 2006..Advanced glycation end products (AGEs) are markers of oxidative stress... - Apoptosis and proliferation of endothelial cells in early atherosclerotic lesions: possible role of oxidised LDLG D Norata
Department of Pharmacological Sciences, University of Milano, Italy
Nutr Metab Cardiovasc Dis 12:297-305. 2002.... - Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cellsG D Norata
Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
Int J Mol Med 16:717-22. 2005..Modulation of gene expression in the endothelium should be taken into account when studying the effects of LXR and RXR agonists on lipid metabolism in the arterial wall... - Overexpression of inducible heat shock protein 70 in Cos-1 cells fails to protect from cytotoxicity of oxidized ldlsA Pirillo
Institute of Pharmacological Sciences, University of Milano, Italy
Arterioscler Thromb Vasc Biol 21:348-54. 2001..Thus, the Hsp70 response, although induced by OxLDLs, cannot protect cells from lipoprotein toxicity... - Triglyceride-rich lipoproteins from hypertriglyceridemic subjects induce a pro-inflammatory response in the endothelium: Molecular mechanisms and gene expression studiesG D Norata
Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
J Mol Cell Cardiol 40:484-94. 2006..These results support the possible involvement of hypertriglyceridemic TGRLs in endothelial dysfunction via induction of a pro-inflammatory and pro-thrombotic state... - The database of Italian general practitioners allows a reliable determination of the prevalence of myocardial infarctionAlessandro Filippi
Italian College of General Practitioners, Florence, Italy
Ital Heart J 6:311-4. 2005..CONCLUSIONS: The prevalence of MI diagnosis in the HSD is very close to that obtained by other epidemiological methods. Querying the database can provide a simple and inexpensive way to estimate and monitor the prevalence of MI in Italy... - Novel statins: pharmacological and clinical resultsChiara Bolego
Nutrition Foundation of Italy, Via S Pietro all'Orto 17, 20121 Milan, Italy
Cardiovasc Drugs Ther 16:251-7. 2002.... - Cholesterol control in stroke prevention in Italy: a cross-sectional study in family practiceAlessandro Filippi
Italian College of General Practitioners, Florence, Italy
Eur J Cardiovasc Prev Rehabil 12:159-63. 2005..However a relatively large number of patients (646) with high plasma lipids remained untreated. CONCLUSIONS: Monitoring and intervention strategies on plasma lipid levels in patients with a diagnosis of stroke or TIA need to be improved... - Secondary prevention of myocardial infarction: a survey in primary careAlessandro Filippi
Italian College of General Practitioners, Florence, Italy
J Cardiovasc Med (Hagerstown) 7:422-6. 2006..Clearly, secondary prevention requires major improvement... - Triglyceride-rich lipoproteins from normotrygliceridemic subjects and hyperlipidemic patients differently affect endothelial cell activation and gene expression patternsGiuseppe D Norata
Circ Res 100:e81. 2007 - Leptin:adiponectin ratio is an independent predictor of intima media thickness of the common carotid arteryGiuseppe Danilo Norata
Stroke 38:2844-6. 2007..52) (P<0.01). CONCLUSIONS: We show here that the L:A ratio is a powerful independent predictor of IMT in healthy subjects and correlates with several anthropometric, metabolic, and clinical parameters better than each single adipokine...