Alberico L Catapano

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. pmc Combination therapy in cholesterol reduction: focus on ezetimibe and statins
    Liliana Grigore
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Vasc Health Risk Manag 4:267-78. 2008
  2. ncbi request reprint Statin-induced myotoxicity: pharmacokinetic differences among statins and the risk of rhabdomyolysis, with particular reference to pitavastatin
    Alberico L Catapano
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Curr Vasc Pharmacol 10:257-67. 2012
  3. ncbi request reprint Treating high density lipoprotein cholesterol (HDL-C): quantity versus quality
    Angela Pirillo
    Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Italy
    Curr Pharm Des 19:3841-57. 2013
  4. doi request reprint The safety of therapeutic monoclonal antibodies: implications for cardiovascular disease and targeting the PCSK9 pathway
    A L Catapano
    Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy IRCCS Multimedica, Italy
    Atherosclerosis 228:18-28. 2013
  5. doi request reprint Global cardiovascular risk : the role of plasma lipids
    Alberico L Catapano
    Department of Pharmacological Sciences, Director Center for the Study of Atherosclerosis, Marie Curie Training Centre for Cardiovascular Diseases, University of Milan, Via G Balzaretti 9 20133, Milan, Italy
    High Blood Press Cardiovasc Prev 12:125-33. 2005
  6. ncbi request reprint Low density lipoprotein oxidation, antioxidants, and atherosclerosis
    A L Catapano
    Institute of Pharmacological Sciences, University of Milan, Italy
    Curr Opin Cardiol 15:355-63. 2000
  7. ncbi request reprint Lipid-altering efficacy of the ezetimibe/simvastatin single tablet versus rosuvastatin in hypercholesterolemic patients
    Alberico L Catapano
    University of Milan, Milan, Italy
    Curr Med Res Opin 22:2041-53. 2006
  8. ncbi request reprint Native LDL and oxidized LDL modulate cyclooxygenase-2 expression in HUVECs through a p38-MAPK, NF-kappaB, CRE dependent pathway and affect PGE2 synthesis
    G D Norata
    Department of Pharmacological Sciences, University of Milan, Italy
    Int J Mol Med 14:353-9. 2004
  9. ncbi request reprint Averting a pandemic health crisis in Europe by 2020: what physicians need to know regarding cholesterol management
    Alberico L Catapano
    Centre for the Study of Atherosclerosis, Marie Curie Training Centre for Cardiovascular Diseases, University of Milan, Milan, Italy
    Eur J Cardiovasc Prev Rehabil 14:340-5. 2007
  10. ncbi request reprint Perspectives on low-density lipoprotein cholesterol goal achievement
    Alberico L Catapano
    Marie Curie Training Centre for Cardiovascular Diseases, University of Milan, Milan, Italy
    Curr Med Res Opin 25:431-47. 2009

Detail Information

Publications59

  1. pmc Combination therapy in cholesterol reduction: focus on ezetimibe and statins
    Liliana Grigore
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Vasc Health Risk Manag 4:267-78. 2008
    ....
  2. ncbi request reprint Statin-induced myotoxicity: pharmacokinetic differences among statins and the risk of rhabdomyolysis, with particular reference to pitavastatin
    Alberico L Catapano
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Curr Vasc Pharmacol 10:257-67. 2012
    ..Such differences in drug � drug interaction profiles among available statins offer the possibility of reducing the risk of myotoxicity among high-risk patients...
  3. ncbi request reprint Treating high density lipoprotein cholesterol (HDL-C): quantity versus quality
    Angela Pirillo
    Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Italy
    Curr Pharm Des 19:3841-57. 2013
    ....
  4. doi request reprint The safety of therapeutic monoclonal antibodies: implications for cardiovascular disease and targeting the PCSK9 pathway
    A L Catapano
    Department of Pharmacological and Biomolecular Sciences, University of Milan, Italy IRCCS Multimedica, Italy
    Atherosclerosis 228:18-28. 2013
    ..Early clinical phase studies suggest these mAbs are effective and well tolerated; however, further studies are required to assess their long-term safety...
  5. doi request reprint Global cardiovascular risk : the role of plasma lipids
    Alberico L Catapano
    Department of Pharmacological Sciences, Director Center for the Study of Atherosclerosis, Marie Curie Training Centre for Cardiovascular Diseases, University of Milan, Via G Balzaretti 9 20133, Milan, Italy
    High Blood Press Cardiovasc Prev 12:125-33. 2005
    ..g. patients with previous myocardial infarction or stroke)...
  6. ncbi request reprint Low density lipoprotein oxidation, antioxidants, and atherosclerosis
    A L Catapano
    Institute of Pharmacological Sciences, University of Milan, Italy
    Curr Opin Cardiol 15:355-63. 2000
    ..When it becomes possible to monitor the efficacy of any antioxidant therapy with validated markers of oxidation, the potential influence of vitamins and antioxidants on coronary artery disease will eventually be resolved...
  7. ncbi request reprint Lipid-altering efficacy of the ezetimibe/simvastatin single tablet versus rosuvastatin in hypercholesterolemic patients
    Alberico L Catapano
    University of Milan, Milan, Italy
    Curr Med Res Opin 22:2041-53. 2006
    ..To assess the lipid-altering efficacy and safety of ezetimibe/simvastatin single tablet product compared with rosuvastatin at the approved usual starting, next highest, and maximum doses...
  8. ncbi request reprint Native LDL and oxidized LDL modulate cyclooxygenase-2 expression in HUVECs through a p38-MAPK, NF-kappaB, CRE dependent pathway and affect PGE2 synthesis
    G D Norata
    Department of Pharmacological Sciences, University of Milan, Italy
    Int J Mol Med 14:353-9. 2004
    ....
  9. ncbi request reprint Averting a pandemic health crisis in Europe by 2020: what physicians need to know regarding cholesterol management
    Alberico L Catapano
    Centre for the Study of Atherosclerosis, Marie Curie Training Centre for Cardiovascular Diseases, University of Milan, Milan, Italy
    Eur J Cardiovasc Prev Rehabil 14:340-5. 2007
    ..According to a recent report by the Stockholm Network (an independent European 'think tank'), major political, economic, social, and medical changes are urgently needed with respect to cholesterol management to help prevent CVD...
  10. ncbi request reprint Perspectives on low-density lipoprotein cholesterol goal achievement
    Alberico L Catapano
    Marie Curie Training Centre for Cardiovascular Diseases, University of Milan, Milan, Italy
    Curr Med Res Opin 25:431-47. 2009
    ..European and US guidelines now recommend lower LDL-C levels, particularly in high-risk patients. Although LDL-C treatment goals to reduce the risk of CHD are clear, many patients do not reach their LDL-C goals...
  11. ncbi request reprint [Intestinal cholesterol absorption: a pharmacological target for lowering of plasma cholesterol]
    Alberico L Catapano
    Dipartimento di Scienze Farmacologiche, Centro per lo Studio dell Aterosclerosi, Universita degli Studi, Milano
    Ital Heart J Suppl 5:779-84. 2004
    ....
  12. doi request reprint Pitavastatin - pharmacological profile from early phase studies
    Alberico L Catapano
    Centre for the Study of Atherosclerosis, Department of Pharmacological Sciences, University of Milan, and IRCSS Multimedica, Sesto S Giovanni, Milan, Italy
    Atheroscler Suppl 11:3-7. 2010
    ..Consequently, pitavastatin has minimal drug-food and drug-drug interactions making it a treatment option in the large group of dyslipidaemic people that require multidrug therapy...
  13. ncbi request reprint The pharmacologic elegance of inhibiting cholesterol absorption and synthesis while providing a homeostatic balance
    Alberico L Catapano
    Center for the Study of Atherosclerosis and Laboratory of Lipoprotein Metabolism, Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Fundam Clin Pharmacol 21:21-6. 2007
    ....
  14. ncbi request reprint Oxidized-HDL3 modulates the expression of Cox-2 in human endothelial cells
    Elisa Callegari
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Int J Mol Med 18:209-13. 2006
    ..These data suggest that Ox-HDL induce Cox-2 expression in endothelial cells through a PI3K/NF-IL6-dependent pathway...
  15. doi request reprint Effect of treatment with pravastatin or ezetimibe on endothelial function in patients with moderate hypercholesterolemia
    Liliana Grigore
    Center for the Study of Atherosclerosis SISA Lombardia, Bassini Hospital, Via Gorki 50, 20092 Cinisello Balsamo, Milan, Italy
    Eur J Clin Pharmacol 69:341-6. 2013
    ....
  16. doi request reprint C-reactive protein distribution and correlation with traditional cardiovascular risk factors in the Italian population
    Manuela Casula
    Epidemiology and Preventive Pharmacology Centre SEFAP, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    Eur J Intern Med 24:161-6. 2013
    ..We report the distribution of plasma levels of CRP and its possible relationship with other cardiovascular risk factors in an Italian cohort...
  17. ncbi request reprint Oxidised-HDL3 induces the expression of PAI-1 in human endothelial cells. Role of p38MAPK activation and mRNA stabilization
    Giuseppe D Norata
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Br J Haematol 127:97-104. 2004
    ..In summary, Ox-HDL3 induced PAI-1 mRNA expression and antigen release through a molecular mechanism involving MAPK activation and mRNA stabilization. Thus, oxidative modification converts HDL to a prothrombotic lipoprotein species...
  18. ncbi request reprint [Rosuvastatin: pharmacologic features]
    Franco Bernini
    Dipartimento di Scienze Farmacologiche, Biologiche e Chimiche Applicate, Universita degli Studi, Campus Universiario, 43100 Parma
    Ital Heart J 4:22S-32S. 2003
    ..Rosuvastatin effectively decreases triglycerides, triglyceride-rich lipoproteins, non-HDL cholesterol, and increases HDL cholesterol. All together these properties will favor the achievement of therapeutic goals in the treated patients...
  19. doi request reprint Cost-effectiveness of enhancing adherence to therapy with statins in the setting of primary cardiovascular prevention. Evidence from an empirical approach based on administrative databases
    Giovanni Corrao
    Department of Statistics, Unit of Biostatistics and Epidemiology, University of Milano Bicocca, Milan, Italy
    Atherosclerosis 217:479-85. 2011
    ..To estimate the cost-effectiveness of enhancing adherence to statin therapy across a large population without signs of pre-existing cardiovascular disease...
  20. ncbi request reprint Modification of HDL3 by mild oxidative stress increases ATP-binding cassette transporter 1-mediated cholesterol efflux
    Angela Pirillo
    Department of Pharmacological Sciences, Via Balzaretti, 9, 20133 Milano, Italy
    Cardiovasc Res 75:566-74. 2007
    ..In the present study we investigated the effect of a mild oxidation of HDL(3) on its function as cholesterol acceptor...
  21. ncbi request reprint High-density lipoproteins induce transforming growth factor-beta2 expression in endothelial cells
    Giuseppe D Norata
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    Circulation 111:2805-11. 2005
    ..In addition to its role in reverse cholesterol transport, HDL influences different functions of endothelial cells. In the present study, we investigated in endothelial cells the genes involved in inflammation modulated by HDL...
  22. doi request reprint Reaching LDL-c targets in high-risk patients requires high-efficacy cholesterol-lowering drugs in more than 50% of cases. The results of the CHECK study
    Andrea Poli
    SEFAP, University of Milan, Milan, Italy
    Pharmacol Res 64:393-6. 2011
    ..Our data might conceivably be applied to other low-cardiovascular risk countries and should be taken into account when defining the proportion of drugs with different efficacy and cost in the everyday clinical practice...
  23. doi request reprint Endothelin-1 does not impair insulin-induced angiogenesis in vitro
    Fabio Pellegatta
    Laboratory of Lipid Metabolism, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, I 20132 Milan, Italy
    Int J Mol Med 28:443-8. 2011
    ..In the two in vitro models of angiogenesis, ET-1 did not inhibit insulin-induced angiogenesis. From these data we conclude that in vitro, at the times and at the concentrations examined, ET-1 does not impair insulin-induced angiogenesis...
  24. doi request reprint Dual effect of hypochlorite in the modification of high density lipoproteins
    Angela Pirillo
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Biochem Biophys Res Commun 403:447-51. 2010
    ....
  25. pmc Molecular mechanisms responsible for the antiinflammatory and protective effect of HDL on the endothelium
    Giuseppe D Norata
    Department of Pharmacological Sciences, University of Milan, Italy
    Vasc Health Risk Manag 1:119-29. 2005
    ....
  26. doi request reprint Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) by 15-lipoxygenase-modified LDL in endothelial cells
    Angela Pirillo
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Atherosclerosis 214:331-7. 2011
    ..Lectin-like oxidized LDL receptor-1 (LOX-1), the endothelial receptor for OxLDL, is believed to be responsible for a number of OxLDL-induced effects in the endothelium...
  27. doi request reprint HDLs, immunity, and atherosclerosis
    Giuseppe D Norata
    Department of Pharmacological Sciences, Universita degli Studi di Milano, Centro SISA per lo Studio dell Aterosclerosi, Ospedale Bassini, Cinisello Balsamo, Milan, Italy
    Curr Opin Lipidol 22:410-6. 2011
    ..Among them, the most relevant is the ability of HDL to promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion...
  28. ncbi request reprint Improvement of endothelial function in uraemic patients on peritoneal dialysis: a possible role for 5-MTHF administration
    Ivano Baragetti
    Department of Internal Medicine, Nephrology and Dialysis Unit, Bassini Hospital, Cinisello Balsamo, Milan, Italy
    Nephrol Dial Transplant 22:3292-7. 2007
    ..In patients with chronic renal failure, the administration of folic acid or its metabolites reduces but does not normalize plasma homocysteine concentrations...
  29. ncbi request reprint High-density lipoprotein subfraction 3 decreases ADAMTS-1 expression induced by lipopolysaccharide and tumor necrosis factor-alpha in human endothelial cells
    Giuseppe D Norata
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Matrix Biol 22:557-60. 2004
    ..Since ADAMTS-1 has recently been shown to inhibit endothelial cell proliferation, the result of the present work may represent a new mechanism by which HDL could have a positive effect on endothelial cell and vascular wall function...
  30. ncbi request reprint Effect of the -420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction
    G D Norata
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Intern Med 262:104-12. 2007
    ..The aim of this study was to investigate the association of the -420C/G polymorphism with metabolic syndrome, obesity, myocardial infarction and kidney disease...
  31. doi request reprint Plasma adiponectin levels in chronic kidney disease patients: relation with molecular inflammatory profile and metabolic status
    G D Norata
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133 Milan, Italy
    Nutr Metab Cardiovasc Dis 20:56-63. 2010
    ..Adiponectin (ADPN) exerts anti-inflammatory and cardio protective effects and is associated with decreased cardiovascular risk, however its role in patients with chronic kidney disease is unclear...
  32. ncbi request reprint Plasma resistin levels correlate with determinants of the metabolic syndrome
    G D Norata
    Centro SISA per lo Studio della Aterosclerosi, Ospedale Bassini, Cinisello Balsamo, Milano, Italy
    Eur J Endocrinol 156:279-84. 2007
    ..The aim of the present study was to investigate the relationship of plasma resistin levels with markers of the metabolic syndrome and atherosclerosis in a large population-based study...
  33. ncbi request reprint Gene expression and intracellular pathways involved in endothelial dysfunction induced by VLDL and oxidised VLDL
    G D Norata
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Cardiovasc Res 59:169-80. 2003
    ..Moreover, as VLDL can enter the arterial wall and undergo oxidative modification, we compared the VLDL-induced expression pattern with the one of oxidised VLDL (Ox-VLDL)...
  34. doi request reprint Long-term effect of high dose omega-3 fatty acid supplementation for secondary prevention of cardiovascular outcomes: A meta-analysis of randomized, placebo controlled trials [corrected]
    Manuela Casula
    Centre of Epidemiology and Preventive Pharmacology SEFAP, Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Atheroscler Suppl 14:243-51. 2013
    ..We performed a meta-analysis of the available RCTs for investigating the CV preventive effect of administrating at least 1 gram/day, and for at least 1 year, omega-3 fatty acid supplements to patients with existing CV disease...
  35. pmc Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal Models
    Enrico Ammirati
    Clinical Cardiovascular Biology Centre, San Raffaele Scientific Institute and the Università Vita Salute San Raffaele, Milan, Italy E A, D C, M B Heart Transplantation Division, Ospedale Niguarda Ca Granda, Milan, Italy E A Heart Care Foundation, Florence, Italy E A, A M
    J Am Heart Assoc 1:27-41. 2012
    ..J Am Heart Assoc. 2012;1:27-41.)...
  36. ncbi request reprint Monitoring statin safety in primary care
    Elena Tragni
    Epidemiology and Preventive Pharmacology Center, Department of Pharmacological Sciences, University of Milan, Via Balzaretti, Milan, Italy
    Pharmacoepidemiol Drug Saf 16:652-7. 2007
    ..To verify General Practitioners (GPs) compliance to the recommended laboratory monitoring for statin users...
  37. doi request reprint Results of a retrospective database analysis of adherence to statin therapy and risk of nonfatal ischemic heart disease in daily clinical practice in Italy
    Giovanni Corrao
    Department of Statistics, Unit of Biostatistics and Epidemiology, University of Milano Bicocca, Milan, Italy
    Clin Ther 32:300-10. 2010
    ..However, inadequate adherence may reduce statins' protective effects...
  38. ncbi request reprint 15-Lipoxygenase-mediated modification of high-density lipoproteins impairs SR-BI- and ABCA1-dependent cholesterol efflux from macrophages
    Angela Pirillo
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Biochim Biophys Acta 1761:292-300. 2006
    ..These results suggest that 15-lipoxygenase might induce structural alterations of HDL3 particles that impair their capability of triggering reverse cholesterol transport...
  39. ncbi request reprint 5-methyltetrahydrofolate restores endothelial function in uraemic patients on convective haemodialysis
    Gherardo Buccianti
    Department of Internal Medicine, Nephrology and Dialysis Unit, Bassini Hospital, Cinisello Balsamo, Milan, Italy
    Nephrol Dial Transplant 17:857-64. 2002
    ..Furthermore, homocysteine induces endothelial dysfunction by an increased inactivation of nitric oxide...
  40. ncbi request reprint HDL3 induces cyclooxygenase-2 expression and prostacyclin release in human endothelial cells via a p38 MAPK/CRE-dependent pathway: effects on COX-2/PGI-synthase coupling
    G D Norata
    Department of Pharmacological Sciences, University of Milan, Italy
    Arterioscler Thromb Vasc Biol 24:871-7. 2004
    ..HDLs have been shown to increase prostacyclin synthesis, thus in the present study we investigated the molecular mechanisms involved in this effect in endothelial cells...
  41. doi request reprint Increased atherosclerosis and vascular inflammation in APP transgenic mice with apolipoprotein E deficiency
    G Tibolla
    Department of Pharmacological Sciences, Universita degli Studi di Milano, 20133 Milan, Italy
    Atherosclerosis 210:78-87. 2010
    ..Aim of this study was to investigate aortic atherosclerosis development in a mouse model with central nervous system (CNS) restricted beta-amyloid precursor protein (APP) overexpression...
  42. doi request reprint 15-Lipoxygenase-Mediated Modification of HDL3 Impairs eNOS Activation in Human Endothelial Cells
    Lucia Cutuli
    Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy
    Lipids 49:317-26. 2014
    ..These findings suggest that modification of HDL may reduce its endothelial-protective role also by interfering with vasodilatory function of HDL. ..
  43. ncbi request reprint Statins and oxidative stress during atherogenesis
    Giuseppe D Norata
    Department of Pharmacological Sciences, University of Milan, and Centro per lo Studio e la Prevenzione delle Vasculopatie Periferiche, Ospedale Bassini, Italy
    J Cardiovasc Risk 10:181-9. 2003
    ..Among their properties statins also possess antioxidant activities and the aim of this paper is to review the scientific evidence for such an effect and its possible clinical relevance...
  44. ncbi request reprint Effect of the Toll-like receptor 4 (TLR-4) variants on intima-media thickness and monocyte-derived macrophage response to LPS
    G D Norata
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    J Intern Med 258:21-7. 2005
    ..We have investigated whether the presence of the D299G polymorphism and the co-segregated T399I polymorphism affects the intima-media thickness (IMT) in the general population...
  45. doi request reprint Omega-3 polyunsaturated fatty acids in the treatment of atherogenic dyslipidemia
    Angela Pirillo
    Center for the Study of Atherosclerosis, Bassini Hospital, Cinisello Balsamo, Italy
    Atheroscler Suppl 14:237-42. 2013
    ..These findings suggest that omega-3 fatty acids may be usefully considered for the management of high TG levels. ..
  46. ncbi request reprint [Achievement of the therapeutic goals for dyslipidemia in clinical practice: results of a survey among general practice physicians from Lombardy]
    Elena Tragni
    Servizio di Epidemiologia e Farmacologia Preventiva SEFAP, Dipartimento di Scienze Farmacologiche, Universita degli Studi, Via Balzaretti, 9 20133 Milano
    Ital Heart J 4:47S-57S. 2003
    ....
  47. ncbi request reprint Effects of HDL3 on the expression of matrix-degrading proteases in human endothelial cells
    Giuseppe D Norata
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Int J Mol Med 12:73-8. 2003
    ..The expression pattern was confirmed by quantitative real-time PCR. In summary, a large repertoire of matrix-degrading proteases is expressed in endothelial cells, an expression that can be modulated by native and oxidized HDL3...
  48. ncbi request reprint Effects of fractalkine receptor variants on common carotid artery intima-media thickness
    Giuseppe D Norata
    Department of Pharmacological Sciences, University of Milan, Italy
    Stroke 37:1558-61. 2006
    ..In the present study, we investigated the possible association between CX3CR1variants and intima-media thickness (IMT)...
  49. ncbi request reprint Apoptosis and proliferation of endothelial cells in early atherosclerotic lesions: possible role of oxidised LDL
    G D Norata
    Department of Pharmacological Sciences, University of Milano, Italy
    Nutr Metab Cardiovasc Dis 12:297-305. 2002
    ....
  50. ncbi request reprint Role of vitamin E-coated membrane in reducing advanced glycation end products in hemodialysis patients: a pilot study
    I Baragetti
    Department of Medicine, Division of Nephrology and Dialysis, Cinisello Balsamo, University of Milan, Milan, Italy
    Blood Purif 24:369-76. 2006
    ..Advanced glycation end products (AGEs) are markers of oxidative stress...
  51. ncbi request reprint Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells
    G D Norata
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Int J Mol Med 16:717-22. 2005
    ..Modulation of gene expression in the endothelium should be taken into account when studying the effects of LXR and RXR agonists on lipid metabolism in the arterial wall...
  52. ncbi request reprint Triglyceride-rich lipoproteins from hypertriglyceridemic subjects induce a pro-inflammatory response in the endothelium: Molecular mechanisms and gene expression studies
    G D Norata
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Mol Cell Cardiol 40:484-94. 2006
    ..These results support the possible involvement of hypertriglyceridemic TGRLs in endothelial dysfunction via induction of a pro-inflammatory and pro-thrombotic state...
  53. ncbi request reprint Overexpression of inducible heat shock protein 70 in Cos-1 cells fails to protect from cytotoxicity of oxidized ldls
    A Pirillo
    Institute of Pharmacological Sciences, University of Milano, Italy
    Arterioscler Thromb Vasc Biol 21:348-54. 2001
    ..Thus, the Hsp70 response, although induced by OxLDLs, cannot protect cells from lipoprotein toxicity...
  54. ncbi request reprint Cholesterol control in stroke prevention in Italy: a cross-sectional study in family practice
    Alessandro Filippi
    Italian College of General Practitioners, Florence, Italy
    Eur J Cardiovasc Prev Rehabil 12:159-63. 2005
    ....
  55. ncbi request reprint Secondary prevention of myocardial infarction: a survey in primary care
    Alessandro Filippi
    Italian College of General Practitioners, Florence, Italy
    J Cardiovasc Med (Hagerstown) 7:422-6. 2006
    ..To collect information on the major risk factors and secondary prevention among patients with myocardial infarction in Italy...
  56. ncbi request reprint The database of Italian general practitioners allows a reliable determination of the prevalence of myocardial infarction
    Alessandro Filippi
    Italian College of General Practitioners, Florence, Italy
    Ital Heart J 6:311-4. 2005
    ..To plan preventive intervention after myocardial infarction (MI) the disease prevalence and the age and time from acute event of the index population should be known...
  57. ncbi request reprint Novel statins: pharmacological and clinical results
    Chiara Bolego
    Nutrition Foundation of Italy, Via S Pietro all Orto 17, 20121 Milan, Italy
    Cardiovasc Drugs Ther 16:251-7. 2002
    ....
  58. ncbi request reprint Triglyceride-rich lipoproteins from normotrygliceridemic subjects and hyperlipidemic patients differently affect endothelial cell activation and gene expression patterns
    Giuseppe D Norata
    Circ Res 100:e81. 2007
  59. ncbi request reprint Leptin:adiponectin ratio is an independent predictor of intima media thickness of the common carotid artery
    Giuseppe Danilo Norata
    Stroke 38:2844-6. 2007
    ..The evaluation of the leptin:adiponectin ratio (L:A) has been suggested as an atherosclerotic index in patients with type 2 diabetes and a useful parameter to assess insulin resistance in patients with and without diabetes...