D Caruso

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi Rapid evaluation of phenolic component profile and analysis of oleuropein aglycon in olive oil by atmospheric pressure chemical ionization-mass spectrometry (APCI-MS)
    D Caruso
    Institute of Pharmacological Sciences, Via Balzaretti, 9, 20133 Milan, Italy and Catholic University of Sacred Heart, Milan, Italy
    J Agric Food Chem 48:1182-5. 2000
  2. ncbi A hemoglobin variant found during glycohemoglobin measurement, identified as Hb Toulon [alpha77(EF6)Pro-->His] by tandem mass spectrometry
    Donatella Caruso
    Department of Pharmacological Sciences, University of Milan, Italy
    Hemoglobin 26:197-9. 2002
  3. ncbi Olive oil phenolics are dose-dependently absorbed in humans
    F Visioli
    Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    FEBS Lett 468:159-60. 2000
  4. ncbi Bile acids and their signaling pathways: eclectic regulators of diverse cellular functions
    E Scotti
    The Giovanni Galli Laboratory of Biochemistry and Molecular Biology of Lipids and of Mass Spectrometry, Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133, Milan, Italy
    Cell Mol Life Sci 64:2477-91. 2007
  5. ncbi Olive oils rich in natural catecholic phenols decrease isoprostane excretion in humans
    F Visioli
    Institute of Pharmacological Sciences, Milan, Italy
    Biochem Biophys Res Commun 278:797-9. 2000
  6. ncbi Hydroxytyrosol, as a component of olive mill waste water, is dose- dependently absorbed and increases the antioxidant capacity of rat plasma
    F Visioli
    Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan
    Free Radic Res 34:301-5. 2001
  7. ncbi Urinary excretion of olive oil phenols and their metabolites in humans
    D Caruso
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Metabolism 50:1426-8. 2001
  8. doi Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling
    F Gilardi
    Laboratory of Biochemistry and Molecular Biology of Lipids Mass spectrometry Giovanni Galli, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
    Neuroscience 164:530-40. 2009
  9. ncbi Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase
    Mario dell'Agli
    Research Centre for the Characterization and Safe use of Natural Compounds, Giovanni Galli, Department of Pharmacological Sciences, University of Milan, Italy
    Br J Nutr 99:945-51. 2008
  10. doi New analytical tools and epidemiological data for the identification of HbA2 borderline subjects in the screening for beta-thalassemia
    Andrea Mosca
    CIRME, Dip di Scienze e Tecnologie Biomediche, Universita degli Studi di Milano, Via F lli Cervi 93, Segrate, Italy
    Bioelectrochemistry 73:137-40. 2008

Collaborators

Detail Information

Publications33

  1. ncbi Rapid evaluation of phenolic component profile and analysis of oleuropein aglycon in olive oil by atmospheric pressure chemical ionization-mass spectrometry (APCI-MS)
    D Caruso
    Institute of Pharmacological Sciences, Via Balzaretti, 9, 20133 Milan, Italy and Catholic University of Sacred Heart, Milan, Italy
    J Agric Food Chem 48:1182-5. 2000
    ..Moreover, oleuropein and its isomers present in the oil are quantified by APCI-MS/MS analysis of the extracts without preliminary separation from other phenolic compounds...
  2. ncbi A hemoglobin variant found during glycohemoglobin measurement, identified as Hb Toulon [alpha77(EF6)Pro-->His] by tandem mass spectrometry
    Donatella Caruso
    Department of Pharmacological Sciences, University of Milan, Italy
    Hemoglobin 26:197-9. 2002
  3. ncbi Olive oil phenolics are dose-dependently absorbed in humans
    F Visioli
    Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milan, Italy
    FEBS Lett 468:159-60. 2000
    ..Furthermore, an increase in the dose of phenolics administered increased the proportion of conjugation with glucuronide...
  4. ncbi Bile acids and their signaling pathways: eclectic regulators of diverse cellular functions
    E Scotti
    The Giovanni Galli Laboratory of Biochemistry and Molecular Biology of Lipids and of Mass Spectrometry, Department of Pharmacological Sciences, University of Milan, Via Balzaretti, 9, 20133, Milan, Italy
    Cell Mol Life Sci 64:2477-91. 2007
    ..In this review, we will summarize the current knowledge of the functions regulated by bile acids and how their physiological receptors mediate the signaling underlying numerous cellular responses...
  5. ncbi Olive oils rich in natural catecholic phenols decrease isoprostane excretion in humans
    F Visioli
    Institute of Pharmacological Sciences, Milan, Italy
    Biochem Biophys Res Commun 278:797-9. 2000
    ..The statistically significant negative correlation between 8-iso-PGF(2alpha) and HValc urinary concentrations suggests that this metabolite better reflects the in vivo activities of hydroxytyrosol...
  6. ncbi Hydroxytyrosol, as a component of olive mill waste water, is dose- dependently absorbed and increases the antioxidant capacity of rat plasma
    F Visioli
    Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan
    Free Radic Res 34:301-5. 2001
    ..Future experiments will eventually further clarify its metabolic fate and its in vivo actions...
  7. ncbi Urinary excretion of olive oil phenols and their metabolites in humans
    D Caruso
    Department of Pharmacological Sciences, University of Milan, Milan, Italy
    Metabolism 50:1426-8. 2001
    ..We also found a significant increase of HVA, indicating an oxidation of the ethanolic residue of HT and/or of HVA1c in humans. The excretion of both metabolites significantly correlated with the dose of administered HT...
  8. doi Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling
    F Gilardi
    Laboratory of Biochemistry and Molecular Biology of Lipids Mass spectrometry Giovanni Galli, Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy
    Neuroscience 164:530-40. 2009
    ....
  9. ncbi Inhibition of platelet aggregation by olive oil phenols via cAMP-phosphodiesterase
    Mario dell'Agli
    Research Centre for the Characterization and Safe use of Natural Compounds, Giovanni Galli, Department of Pharmacological Sciences, University of Milan, Italy
    Br J Nutr 99:945-51. 2008
    ..Olive oil extracts and part of its phenolic constituents inhibit platelet aggregation; cAMP-PDE inhibition is one mechanism through which olive oil phenols inhibit platelet aggregation...
  10. doi New analytical tools and epidemiological data for the identification of HbA2 borderline subjects in the screening for beta-thalassemia
    Andrea Mosca
    CIRME, Dip di Scienze e Tecnologie Biomediche, Universita degli Studi di Milano, Via F lli Cervi 93, Segrate, Italy
    Bioelectrochemistry 73:137-40. 2008
    ....
  11. doi Antiplasmodial activity of Punica granatum L. fruit rind
    Mario dell'Agli
    Department of Pharmacological Sciences, University of Camerino, Italy
    J Ethnopharmacol 125:279-85. 2009
    ..Urolithins, the ellagitannin metabolites, were also investigated for antiplasmodial activity...
  12. doi Simultaneous quantification of 8-iso-prostaglandin-F(2alpha) and 11-dehydro thromboxane B(2) in human urine by liquid chromatography-tandem mass spectrometry
    Viviana Cavalca
    Universita degli Studi di Milano, Dipartimento di Scienze Cardiovascolari, 20138 Milano, Italy
    Anal Biochem 397:168-74. 2010
    ..60; P=0.032). This highly sensitive, precise, and rapid method allows for the simultaneous determination of 8-iso-PGF(2alpha) and 11-DH-TXB(2) in human urine samples in order to evaluate oxidative stress and platelet aggregation...
  13. ncbi Hydroxytyrosol excretion differs between rats and humans and depends on the vehicle of administration
    Francesco Visioli
    Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Nutr 133:2612-5. 2003
    ..These data suggest that the rat is not the appropriate model for the study of HT metabolism and that HT-containing functional foods should be carefully formulated...
  14. doi Olive oil phenols modulate the expression of metalloproteinase 9 in THP-1 cells by acting on nuclear factor-kappaB signaling
    Mario dell'Agli
    Research Centre for the Characterization and Safe Use of Natural Compounds Giovanni Galli, University of Milano, Via Balzaretti, 9, 20133 Milano, Italy
    J Agric Food Chem 58:2246-52. 2010
    ..Our findings provide further evidence on the mechanisms by which olive oil reduces the inflammatory burden associated with disorders, such as atherosclerosis...
  15. ncbi Minor components of olive oil modulate proatherogenic adhesion molecules involved in endothelial activation
    Mario dell'Agli
    Department of Pharmacological Sciences, University of Milan, Italy
    J Agric Food Chem 54:3259-64. 2006
    ..These results supply new insights on the protective role of olive oil against vascular risk through the down-regulation of adhesion molecules involved in early atherogenesis...
  16. ncbi High pressure liquid chromatography and electrospray ionization mass spectrometry are advantageously integrated into a two-levels approach to detection and identification of haemoglobin variants
    D Caruso
    Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, Milan, Italy
    Clin Lab Haematol 27:111-9. 2005
    ..Deoxyhaemoglobin solubility test was positive only in the presence of HbS. We conclude that HPLC and ESI-MS are advantageously integrated into a two-level analytical system for the detection and confirmation of variant Hbs...
  17. doi Liver X receptors, nervous system, and lipid metabolism
    G Cermenati
    Department of Pharmacological and Biomolecular Sciences, University of Milan, Via Balzaretti 9, Milan, Italy
    J Endocrinol Invest 36:435-43. 2013
    ..Here, we review a survey of the literature focused on the central and peripheral nervous system and in physiological and pathological settings with particular attention to the roles played by LXR in both districts. ..
  18. ncbi Synthesis of long-chain polyunsaturated fatty acids is inhibited in vivo in hypercholesterolemic rabbits and in vitro by oxysterols
    P Rise
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Prostaglandins Leukot Essent Fatty Acids 71:79-86. 2004
    ..In conclusion, atherogenic oxysterols interfere with the production of long-chain polyunsaturated fatty acids from their precursors both in hypercholesterolemic rabbits and in cultured cells...
  19. ncbi Virgin Olive Oil Study (VOLOS): vasoprotective potential of extra virgin olive oil in mildly dyslipidemic patients
    Francesco Visioli
    Dept of Pharmacological Sciences, University of Milan, Milan, Italy
    Eur J Nutr 44:121-7. 2005
    ..In vitro, olive phenols exert potent antioxidant and enzyme-modulating activities...
  20. ncbi LXR (liver X receptor) and HNF-4 (hepatocyte nuclear factor-4): key regulators in reverse cholesterol transport
    M Crestani
    Dipartimento di Scienze Farmacologiche, Facolta di Farmacia, Universita degli Studi di Milano, Via Balzaretti, 9, 20133 Milano, Italia
    Biochem Soc Trans 32:92-6. 2004
    ..Based on this evidence, these nuclear receptors are candidate targets of new drugs for the treatment and prevention of atherosclerotic disease...
  21. ncbi Proinflammatory lipoxygenase products from peripheral mononuclear cells in patients with rheumatoid arthritis
    S Colli
    E Grossi Paoletti Center, Institute of Pharmacological Sciences, University of Milan, Italy
    J Lab Clin Med 112:357-62. 1988
    ....
  22. doi Neuroactive Steroid Levels in a transgenic rat model of CMT1A Neuropathy
    Donatella Caruso
    Department of Pharmacological Sciences and Center for Metrological Traceability in Laboratory Medicine, University of Milan, Milan, Italy
    J Mol Neurosci 34:249-53. 2008
    ..Thus, the present findings may be considered an interesting background for experiments aimed to evaluate the possible therapeutic effects of modulators of this neurotransmitter receptor in male and female PMP22(tg) rats...
  23. pmc Activation of the liver X receptor increases neuroactive steroid levels and protects from diabetes-induced peripheral neuropathy
    Gaia Cermenati
    Department of Pharmacological Sciences, Giovanni Armenise Harvard Foundation Laboratory, Universita degli Studi di Milano, Milano, Italy
    J Neurosci 30:11896-901. 2010
    ..These results suggest that LXR activation may represent a new pharmacological avenue to increase local neuroactive steroid levels that exert neuroprotective effects in diabetic neuropathy...
  24. ncbi Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle
    Emma De Fabiani
    Dipartimento di Scienze Farmacologiche, Facolta di Farmacia, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    J Biol Chem 278:39124-32. 2003
    ....
  25. ncbi The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol
    Federica Gilardi
    Dipartimento di Scienze Farmacologiche, Universita degli Studi di Milano, Milan, Italy
    Pharmacol Ther 116:449-72. 2007
    ..In recent years, new drugs have been designed based on recent discoveries of the regulatory network, thus confirming the position of CYP7A1 as a focus for innovative pharmacological intervention...
  26. doi Sex-dimorphic changes in neuroactive steroid levels after chronic experimental autoimmune encephalomyelitis
    Donatella Caruso
    Department of Pharmacological Sciences, Universita degli Studi di Milano, Milano, Italy
    J Neurochem 114:921-32. 2010
    ..The specific changes in neuroactive steroid levels after chronic EAE may be of relevance to design new possible therapeutic strategies for the disease...
  27. pmc An innovative method to classify SERMs based on the dynamics of estrogen receptor transcriptional activity in living animals
    Gianpaolo Rando
    Department of Pharmacological Sciences, Center of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy
    Mol Endocrinol 24:735-44. 2010
    ..The application of this methodology is expected to simplify the identification of families of molecules functionally correlated and to speed up the process of drug discovery...
  28. ncbi Evaluation of neuroactive steroid levels by liquid chromatography-tandem mass spectrometry in central and peripheral nervous system: effect of diabetes
    Donatella Caruso
    Department of Pharmacological Sciences, University of Milan, Milano, Italy
    Neurochem Int 52:560-8. 2008
    ....
  29. ncbi Bile acids and gene regulation: from nuclear receptors to chromatin
    Nico Mitro
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Front Biosci 13:6276-88. 2008
    ....
  30. ncbi Bile acid signaling to the nucleus: finding new connections in the transcriptional regulation of metabolic pathways
    Emma De Fabiani
    Dipartimento di Scienze Farmacologiche, Facolta di Farmacia, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Biochimie 86:771-8. 2004
    ..e. glucose metabolism) by modulating gene transcription through multiple mechanisms. These findings also open new perspectives towards the exploitation of bile acid metabolism as a pharmacological target...
  31. ncbi Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis
    Nico Mitro
    Laboratorio Giovanni Galli di Biochimica e Biologia Molecolare dei Lipidi e di Spettrometria di Massa, Dipartimento di Scienze Farmacologiche, Facolta di Farmacia, Universita degli Studi di Milano, Milan, Italy
    Hepatology 46:885-97. 2007
    ....
  32. ncbi Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women
    Simonetta Salvini
    Molecular and Nutritional Epidemiology Unit, Centro per lo Studio e la Prevenzione Oncologica CSPO, Scientific Institute of Tuscany, Florence, Italy
    Br J Nutr 95:742-51. 2006
    ..Despite the small sample size, the present study showed a reduction of DNA damage by consumption of an EVOO rich in phenols, particularly hydroxytyrosol...
  33. ncbi Olive oil and modulation of cell signaling in disease prevention
    Klaus W J Wahle
    School of Life Sciences, The Robert Gordon University, Aberdeen, AB25 1 HG, Scotland, United Kingdom
    Lipids 39:1223-31. 2004
    ..Adoption of a Mediterranean diet could confer health benefits in high-risk populations...