Gaetano Caramori

Summary

Affiliation: University of Ferrara
Country: Italy

Publications

  1. pmc Primary Pulmonary Epithelioid Hemangioendothelioma: A Rare Cause of PET-Negative Pulmonary Nodules
    Riccardo Cazzuffi
    Sezione di Malattie dell Apparato Respiratorio, Dipartimento di Medicina Clinica e Sperimentale, Universita di Ferrara, Italy
    Case Report Med 2011:262674. 2011
  2. doi request reprint Profile of fluticasone furoate/vilanterol dry powder inhaler combination therapy as a potential treatment for COPD
    Gaetano Caramori
    Centro Interdipartimentale per lo Studio delle Malattie Infiammatorie delle vie Aeree e Patologie Fumo correlate CEMICEF formerly Centro di Ricerca su Asma e BPCO, Sezione di Medicina Interna e Cardiorespiratoria, Universita di Ferrara, Ferrara, Italy
    Int J Chron Obstruct Pulmon Dis 9:249-56. 2014
  3. ncbi request reprint Chemokines and chemokine receptors blockers as new drugs for the treatment of chronic obstructive pulmonary disease
    G Caramori
    Centro Interdipartimentale per lo Studio delle Malattie Infiammatorie delle Vie Aeree e Patologie Fumocorrelate CEMICEF formerly Centro di Ricerca su Asma e BPCO, Università di Ferrara Via Savonarola 9 44121 Ferrara, Italy
    Curr Med Chem 20:4317-49. 2013
  4. ncbi request reprint Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review
    G Caramori
    Sezione di Malattie dell Apparato Respiratorio, Centro per lo Studio delle Malattie Infiammatorie Croniche delle Vie Aeree e Patologie Fumo Correlate dell Apparato Respiratorio CEMICEF, Dipartimento di Scienze Mediche, University of Ferrara, Italy
    Monaldi Arch Chest Dis 79:44-8. 2013
  5. doi request reprint Role of transcription factors in the pathogenesis of asthma and COPD
    Gaetano Caramori
    Centro Interdipartimentale per lo Studio delle Malattie Infiammatorie delle Vie Aeree e Patologie Fumo correlate CEMICEF formerly named Centro di Ricerca su Asma e BPCO, Sezione di Malattie dell Apparato Respiratorio, Universita di Ferrara, Ferrara, Italy
    Cell Commun Adhes 20:21-40. 2013
  6. pmc STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects
    Katsuyuki Tomita
    Department of Respiratory Medicine and Allergology, Kinki University School of Medicine, Osaka, Japan
    J Inflamm (Lond) 9:5. 2012
  7. doi request reprint [Role of stem cells in the pathogenesis of chronic obstructive pulmonary disease and of pulmonary emphysema]
    Gaetano Caramori
    Dipartimento di Medicina, Universita di Ferrara, Italy
    Recenti Prog Med 103:31-40. 2012
  8. doi request reprint Clinical definition of COPD exacerbations and classification of their severity
    Gaetano Caramori
    Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
    South Med J 102:277-82. 2009
  9. doi request reprint Mechanisms involved in lung cancer development in COPD
    Gaetano Caramori
    Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
    Int J Biochem Cell Biol 43:1030-44. 2011
  10. doi request reprint MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients
    Gaetano Caramori
    Centro di Ricerca su Asma e BPCO, University of Ferrara, Via Savonarola 9, Ferrara 44121, Italy
    Histopathology 55:321-31. 2009

Collaborators

Detail Information

Publications47

  1. pmc Primary Pulmonary Epithelioid Hemangioendothelioma: A Rare Cause of PET-Negative Pulmonary Nodules
    Riccardo Cazzuffi
    Sezione di Malattie dell Apparato Respiratorio, Dipartimento di Medicina Clinica e Sperimentale, Universita di Ferrara, Italy
    Case Report Med 2011:262674. 2011
    ..At the 18F-fluorodeoxyglucose positron emission tomography, these nodules were negative. The histopathological diagnosis was made on a pulmonary wedge resection (performed during video-thoracoscopic surgery)...
  2. doi request reprint Profile of fluticasone furoate/vilanterol dry powder inhaler combination therapy as a potential treatment for COPD
    Gaetano Caramori
    Centro Interdipartimentale per lo Studio delle Malattie Infiammatorie delle vie Aeree e Patologie Fumo correlate CEMICEF formerly Centro di Ricerca su Asma e BPCO, Sezione di Medicina Interna e Cardiorespiratoria, Universita di Ferrara, Ferrara, Italy
    Int J Chron Obstruct Pulmon Dis 9:249-56. 2014
    ....
  3. ncbi request reprint Chemokines and chemokine receptors blockers as new drugs for the treatment of chronic obstructive pulmonary disease
    G Caramori
    Centro Interdipartimentale per lo Studio delle Malattie Infiammatorie delle Vie Aeree e Patologie Fumocorrelate CEMICEF formerly Centro di Ricerca su Asma e BPCO, Università di Ferrara Via Savonarola 9 44121 Ferrara, Italy
    Curr Med Chem 20:4317-49. 2013
    ..These agents may not only provide improved management of COPD but also, importantly, indicate proof-of-concept to further clarify the role of chemokines in the pathophysiology of COPD. ..
  4. ncbi request reprint Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review
    G Caramori
    Sezione di Malattie dell Apparato Respiratorio, Centro per lo Studio delle Malattie Infiammatorie Croniche delle Vie Aeree e Patologie Fumo Correlate dell Apparato Respiratorio CEMICEF, Dipartimento di Scienze Mediche, University of Ferrara, Italy
    Monaldi Arch Chest Dis 79:44-8. 2013
    ..These findings were confirmed using a validated real time PCR assay demonstrating the presence of the BCG genome in transbronchial and bladder biopsies...
  5. doi request reprint Role of transcription factors in the pathogenesis of asthma and COPD
    Gaetano Caramori
    Centro Interdipartimentale per lo Studio delle Malattie Infiammatorie delle Vie Aeree e Patologie Fumo correlate CEMICEF formerly named Centro di Ricerca su Asma e BPCO, Sezione di Malattie dell Apparato Respiratorio, Universita di Ferrara, Ferrara, Italy
    Cell Commun Adhes 20:21-40. 2013
    ....
  6. pmc STAT6 expression in T cells, alveolar macrophages and bronchial biopsies of normal and asthmatic subjects
    Katsuyuki Tomita
    Department of Respiratory Medicine and Allergology, Kinki University School of Medicine, Osaka, Japan
    J Inflamm (Lond) 9:5. 2012
    ..abstract:..
  7. doi request reprint [Role of stem cells in the pathogenesis of chronic obstructive pulmonary disease and of pulmonary emphysema]
    Gaetano Caramori
    Dipartimento di Medicina, Universita di Ferrara, Italy
    Recenti Prog Med 103:31-40. 2012
    ..Moreover, the potential side effects of the stem cell therapy are often underestimated. We should not ignore that some of the most deadly neoplasms are arising from stem cells...
  8. doi request reprint Clinical definition of COPD exacerbations and classification of their severity
    Gaetano Caramori
    Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
    South Med J 102:277-82. 2009
    ..There is a need for greater investment in research on COPD exacerbations in order to promote a better understanding of COPD exacerbations...
  9. doi request reprint Mechanisms involved in lung cancer development in COPD
    Gaetano Caramori
    Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
    Int J Biochem Cell Biol 43:1030-44. 2011
    ....
  10. doi request reprint MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients
    Gaetano Caramori
    Centro di Ricerca su Asma e BPCO, University of Ferrara, Via Savonarola 9, Ferrara 44121, Italy
    Histopathology 55:321-31. 2009
    ..The aim was to investigate gland size and MUC5AC and MUC5B expression in bronchial rings from smokers with COPD compared with control groups...
  11. pmc New drugs targeting Th2 lymphocytes in asthma
    Gaetano Caramori
    Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
    J Occup Med Toxicol 3:S6. 2008
    ..Some of these new Th2-oriented strategies may in the future not only control symptoms and modify the natural course of asthma, but also potentially prevent or cure the disease...
  12. ncbi request reprint [Treatment of bronchial asthma in adults. Current advances]
    Gaetano Caramori
    Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita, Ferrara
    Recenti Prog Med 100:171-9. 2009
    ..Considering its efficacy and safety the current pharmacological treatment of asthma will probably remain unchanged for the next 10 years...
  13. ncbi request reprint COPD pathology in the small airways
    G Caramori
    Asthma and COPD Research Center, University of Ferrara, Ferrara, Italy
    Panminerva Med 53:51-70. 2011
    ..This review summarizes and discusses the pathology of small airways of stable COPD patients, of different severity, compared with control smokers with normal lung function...
  14. doi request reprint Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer
    Gaetano Caramori
    Centro di Ricerca su Asma e BPCO, University of Ferrara, Via Savonarola, 9, Ferrara 44100, Italy
    Thorax 66:521-7. 2011
    ..Chronic obstructive pulmonary disease (COPD) is characterised by oxidative stress and increased risk of lung carcinoma. Oxidative stress causes DNA damage which can be repaired by DNA-dependent protein kinase complex...
  15. pmc Immune response to Mycobacterium tuberculosis infection in the parietal pleura of patients with tuberculous pleurisy
    Gaetano Caramori
    Section of Respiratory Diseases, University of Ferrara, Ferrara, Italy
    PLoS ONE 6:e22637. 2011
    ..Elevated CD3, CD4, CCR4 and Th17 cells and decreased mast cells and GATA-3+ cells in the parietal pleura distinguish patients with untreated tuberculous pleurisy from those with nonspecific pleuritis...
  16. doi request reprint Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor κB and c-Jun N-terminal kinase activation
    Alberto Papi
    Section of Respiratory Diseases, Department of Medical Sciences, University of Ferrara, Ferrara, Italy Electronic address
    J Allergy Clin Immunol 132:1075-1085.e6. 2013
    ..Although inhaled glucocorticoids are the mainstays of asthma treatment, they are poorly effective at treating and preventing virus-induced asthma exacerbations. The major viruses precipitating asthma exacerbations are rhinoviruses...
  17. doi request reprint Rescue treatment in asthma. More than as-needed bronchodilation
    Alberto Papi
    Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Via Savonarola 9, 44100 Ferrara, Italy
    Chest 135:1628-33. 2009
    ..In the future it might even be possible to control asthma entirely with PRN combination inhalers without maintenance therapy, at least in patients with less severe disease...
  18. doi request reprint Deficient antiviral immune responses in childhood: distinct roles of atopy and asthma
    Simonetta Baraldo
    Department of Cardiac, Thoracic and Vascular Sciences, Section of Respiratory Diseases, University of Padova, Padua, Italy
    J Allergy Clin Immunol 130:1307-14. 2012
    ..Impaired immune response to viral infections in atopic asthmatic patients has been recently reported and debated. Whether this condition is present in childhood and whether it is affected by atopy per se deserves further investigation...
  19. doi request reprint A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease
    John A Marwick
    Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
    J Allergy Clin Immunol 125:1146-53. 2010
    ..This reduction in glucocorticoid sensitivity might be due to an oxidant-mediated increase in phosphoinositol 3-kinase (PI3K) delta signaling...
  20. doi request reprint Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future
    Kian Fan Chung
    Airway Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW36LY, UK
    Eur J Clin Pharmacol 65:853-71. 2009
    ..Other agents that could improve the efficacy of corticosteroids or reverse corticosteroid insensitivity may be added to ICS. ICS in combination with LABAs will continue to remain the main focus of treatment of airways diseases...
  21. doi request reprint Fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease: 5-year follow-up
    Marco Contoli
    Research Centre on Asthma and COPD, Department of Clinical and Experimental Medicine, University of Ferrara, Ferrara, Italy
    J Allergy Clin Immunol 125:830-7. 2010
    ..Both smokers and patients with asthma can experience fixed airflow obstruction, which is associated with distinctive patterns of airway pathology. The influence of fixed airflow obstruction on the prognosis of these patients is unknown...
  22. ncbi request reprint Molecular mechanisms of respiratory virus-induced asthma and COPD exacerbations and pneumonia
    Gaetano Caramori
    Centro di Ricerca su Asma e BPCO, University of Ferrara, Italy
    Curr Med Chem 13:2267-90. 2006
    ..Clearly this is an exciting new area of ongoing research with promising therapeutic potential...
  23. doi request reprint Oxidative/nitrosative stress selectively altered A(2B) adenosine receptors in chronic obstructive pulmonary disease
    Katia Varani
    Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Via Fossato di Mortara 17 19, 44100 Ferrara, Italy
    FASEB J 24:1192-204. 2010
    ..Triggiani, M., Hansel, T., Leung, E., MacLennan, S., Barnes, P. J., Fan Chung, K., Adcock, I., Papi, A., Borea, P. A. Oxidative/nitrosative stress selectively altered A(2B) adenosine receptors in chronic obstructive pulmonary disease...
  24. ncbi request reprint A human rhinovirus model of chronic obstructive pulmonary disease exacerbations
    Marco Contoli
    Department of Clinical and Experimental Medicine, Research Center on Asthma and COPD, University of Ferrara, Ferrara, Italy
    Contrib Microbiol 14:101-12. 2007
    ..In this chapter we will focus on the role of viral infections in COPD exacerbations and will discuss preliminary reports regarding the development of this human model of virus-induced COPD exacerbation...
  25. ncbi request reprint Targeting Th2 cells in asthmatic airways
    Gaetano Caramori
    Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Italy
    Curr Drug Targets Inflamm Allergy 3:243-55. 2004
    ..Some of these new Th2-oriented strategies may in the future not only control symptoms, but also potentially prevent or cure the disease...
  26. doi request reprint Asthma: a chronic infectious disease?
    Gaetano Caramori
    Section of Respiratory Diseases, Department of Medical Sciences, Centro per lo Studio delle Malattie Infiammatorie Croniche delle Vie Aeree e Patologie Fumo Correlate dell Apparato Respiratorio, University of Ferrara, Via Savonarola 9, 44121, Ferrara, Italy
    Clin Chest Med 33:473-84. 2012
    ..The role of bacterial infections in chronic asthma remains unclear. This article reviews the available evidence indicating that asthma may be considered as a chronic infectious disease...
  27. ncbi request reprint Models of infection and exacerbations in COPD
    Alberto Papi
    Department of Clinical and Experimental Medicine, Research Centre on Asthma and COPD, University of Ferrara, Ferrara, Italy
    Curr Opin Pharmacol 7:259-65. 2007
    ..The model will give us the opportunity to highlight key inflammatory mediators representing possible therapeutic targets for the development of novel drugs able to treat and prevent acute episodes in COPD...
  28. pmc Pathophysiology of viral-induced exacerbations of COPD
    Alfredo Potena
    Unita Operativa di Fisiopatologia Respiratoria, Azienda Ospedaliera Universitaria Arcispedale S Anna, Ferrara, Italy
    Int J Chron Obstruct Pulmon Dis 2:477-83. 2007
    ..In this review we will focus our attention on the relationship between common respiratory viral infections and the molecular and inflammatory mechanisms that lead to COPD exacerbation...
  29. pmc Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
    Nathan W Bartlett
    Department of Respiratory Medicine, UK National Heart and Lung Institute, and Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, London W2 1PG, UK
    Nat Med 14:199-204. 2008
    ..These models have features similar to those observed in rhinovirus infection in humans, including augmentation of allergic airway inflammation, and will be useful in the development of future therapies for colds and asthma exacerbations...
  30. ncbi request reprint Transcription factors in asthma and COPD
    Gaetano Caramori
    Dipartimento di Medicina Clinica e Sperimentale, Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Via Savonarola 9, Italy
    IDrugs 7:764-70. 2004
    ..Several new compounds based on interactions with specific transcription factors or their activation pathways are now in development for the treatment of asthma and COPD...
  31. ncbi request reprint Chemokine receptor inhibitors as a novel option in treatment of asthma
    Ian M Adcock
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College London, UK
    Curr Drug Targets Inflamm Allergy 3:257-61. 2004
    ..Furthermore, it is possible that early treatment with these agents may prevent the disease from becoming established...
  32. ncbi request reprint Expression and activity of histone deacetylases in human asthmatic airways
    Kazuhiro Ito
    Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London, SW3 6LY UK
    Am J Respir Crit Care Med 166:392-6. 2002
    ..The increase in HAT activity and reduced HDAC activity in asthma may underlie the increased expression of multiple inflammatory genes, and this is reversed, at least in part, by treatment with inhaled steroids...
  33. ncbi request reprint Decreased histone deacetylase activity in chronic obstructive pulmonary disease
    Kazuhiro Ito
    Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
    N Engl J Med 352:1967-76. 2005
    ..HDAC is a key molecule in the repression of production of proinflammatory cytokines in alveolar macrophages...
  34. doi request reprint New targets for drug development in asthma
    Ian M Adcock
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    Lancet 372:1073-87. 2008
    ..Although a cure is unlikely to be developed in the near future, a greater understanding of disease mechanisms could bring such a situation nearer to reality...
  35. ncbi request reprint Is there a difference between chronic airway inflammation in chronic severe asthma and chronic obstructive pulmonary disease?
    Gaetano Caramori
    Department of Clinical and Experimental Medicine, Centre of Research on Asthma and COPD, University of Ferrara, Ferrara, Italy
    Curr Opin Allergy Clin Immunol 5:77-83. 2005
    ....
  36. ncbi request reprint Pharmacology of airway inflammation in asthma and COPD
    Gaetano Caramori
    Department of Thoracic Medicine, National Heart and Lung Institute at Imperial College School of Science, Technology and Medicine, Dovehouse Street, SW3 6LY, London, UK
    Pulm Pharmacol Ther 16:247-77. 2003
    ..We review the current status of some of these new potential drugs...
  37. doi request reprint Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice
    John A Marwick
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Am J Respir Crit Care Med 179:542-8. 2009
    ..Recent studies have shown that histone deacetylase activity, which is critical to glucocorticoid function, is altered by oxidant stress and may be involved in the development of glucocorticoid insensitivity...
  38. ncbi request reprint New insights into the molecular mechanisms of corticosteroids actions
    Ian M Adcock
    Cell and Molecular Biology, Airways Disease Section, National Heart and Lung Institute, Imperial College London, UK
    Curr Drug Targets 7:649-60. 2006
    ..Therapies targeting these aspects of the glucocorticoid receptor activation pathway may reverse steroid resistance in patients with chronic obstructive pulmonary disease...
  39. ncbi request reprint Gene-environment interactions in the development of chronic obstructive pulmonary disease
    Gaetano Caramori
    Centro di Ricerca su Asma e BPCO, Universita di Ferrara, Ferrara, Italy
    Curr Opin Allergy Clin Immunol 6:323-8. 2006
    ..Recent studies have begun to shed some light on these gene-environment interactions...
  40. ncbi request reprint Anti-inflammatory mechanisms of glucocorticoids targeting granulocytes
    Gaetano Caramori
    Department of Thoracic Medicine, National Heart and Lung Institute at Imperial College School of Science, Technology and Medicine, Dovehouse Street, London, SW3 6LY, UK
    Curr Drug Targets Inflamm Allergy 4:455-63. 2005
    ..We summarize these known mechanisms at the end of this review...
  41. ncbi request reprint Kinase inhibitors and airway inflammation
    Ian M Adcock
    Cell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3, 6LY, United Kingdom
    Eur J Pharmacol 533:118-32. 2006
    ....
  42. ncbi request reprint Anti-inflammatory inhibitors of IkappaB kinase in asthma and COPD
    Gaetano Caramori
    Airways Disease Section, National Heart and Lung Institute, Imperal College London, Dovehouse Street, London SW3 6LY, UK
    Curr Opin Investig Drugs 5:1141-7. 2004
    ..Here, we review some of the major NFkappaB activating pathways, their role in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD), and their potential as targets in the treatment of asthma and COPD...
  43. ncbi request reprint Effect of acute and chronic inflammatory stimuli on expression of protease-activated receptors 1 and 2 in alveolar macrophages
    Nicolas Roche
    Department of Thoracic Medicine, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK
    J Allergy Clin Immunol 111:367-73. 2003
    ....
  44. ncbi request reprint Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease
    Kazuhiro Ito
    Airways Disease Section, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London, SW3, 6LY, UK
    J Pharmacol Exp Ther 321:1-8. 2007
    ..Encouraging data from animal models, primary cells and clinical studies in other diseases suggest that inhibitors of PI3K/Akt may prove to be useful novel therapies in the treatment of asthma and chronic obstructive pulmonary disease...
  45. ncbi request reprint Kinase targets and inhibitors for the treatment of airway inflammatory diseases: the next generation of drugs for severe asthma and COPD?
    Ian M Adcock
    Department of Thoracic Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    BioDrugs 18:167-80. 2004
    ....
  46. ncbi request reprint Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness
    Paul R Eynott
    National Heart and Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK
    Eur J Pharmacol 452:123-33. 2002
    ..NO generated through NOS2 contributes to allergen-induced bronchial hyperresponsiveness but not to bronchial eosinophilia, indicating that these are independently expressed...
  47. pmc Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells
    Shaoping Xie
    Experimental Studies, National Heart and Lung Institute, Imperial College, London, UK
    Respir Res 6:148. 2005
    ..We investigated whether human airway smooth muscle cells could express and secrete MMP-12, thereby participating in the pathogenesis of airway inflammatory diseases...