P Caraceni

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. pmc An innovative hyperbaric hypothermic machine perfusion protects the liver from experimental preservation injury
    Ferdinando A Giannone
    Department of Clinical Medicine, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy
    ScientificWorldJournal 2012:573410. 2012
  2. pmc Acute Liver Failure Caused by Amanita phalloides Poisoning
    Luca Santi
    U O Semeiotica Medica, Department of Clinical Medicine, Alma Mater Studiorum University of Bologna, Via Albertoni 15, 40138 Bologna, Italy
    Int J Hepatol 2012:487480. 2012
  3. doi Clinical indications for the albumin use: still a controversial issue
    Paolo Caraceni
    U O Semeiotica Medica, Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy Electronic address
    Eur J Intern Med 24:721-8. 2013
  4. ncbi Effects of granulocyte colony stimulating-factor in a rat model of acute liver injury
    P Caraceni
    Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, and Ospedale Policlinico S Orsola Malpighi, Bologna, Italy
    Dig Liver Dis 39:943-51. 2007
  5. doi The role of the endocannabinoid system in liver diseases
    Paolo Caraceni
    Department of Clinical Medicine, Center for Applied Biomedical Research C R B A, Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Best Pract Res Clin Endocrinol Metab 23:65-77. 2009
  6. doi The endocannabinoid system and liver diseases
    P Caraceni
    Department of Internal Medicine, Cardioangiology, Hepatology, Alma Mater Studiorum University of Bologna, Bologna, Italy
    J Neuroendocrinol 20:47-52. 2008
  7. ncbi The nutritional status modulates preservation-reperfusion injury in rat fatty liver
    Paolo Caraceni
    Department of Internal Medicine, Cardioangiology, and Hepatology, University of Bologna, Bologna, Italy
    J Surg Res 127:190-6. 2005
  8. doi Long-term treatment of hepatorenal syndrome as a bridge to liver transplantation
    Paolo Caraceni
    Department of Clinical Medicine, Alma Mater Studiorum University of Bologna, Italy
    Dig Liver Dis 43:242-5. 2011
  9. doi Antagonism of the cannabinoid CB-1 receptor protects rat liver against ischaemia-reperfusion injury complicated by endotoxaemia
    P Caraceni
    Department of Clinical Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Gut 58:1135-43. 2009
  10. ncbi Technical aspects of portal vein arterialization for acute liver failure: from rat lab to man
    B Nardo
    Department of Surgery and Transplantations, S Orsola Malpighi Hospital, University of Bologna, Italy
    Transplant Proc 38:1195-7. 2006

Collaborators

Detail Information

Publications43

  1. pmc An innovative hyperbaric hypothermic machine perfusion protects the liver from experimental preservation injury
    Ferdinando A Giannone
    Department of Clinical Medicine, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy
    ScientificWorldJournal 2012:573410. 2012
    ..Thus, we test an innovative hyperbaric hypothermic machine perfusion (HHMP), which combines hyperbaric oxygenation of the preservation solution and continuous perfusion of the graft...
  2. pmc Acute Liver Failure Caused by Amanita phalloides Poisoning
    Luca Santi
    U O Semeiotica Medica, Department of Clinical Medicine, Alma Mater Studiorum University of Bologna, Via Albertoni 15, 40138 Bologna, Italy
    Int J Hepatol 2012:487480. 2012
    ..The use of extracorporeal liver assist devices as well as auxiliary liver transplantation may represent additional therapeutic options...
  3. doi Clinical indications for the albumin use: still a controversial issue
    Paolo Caraceni
    U O Semeiotica Medica, Department of Medical and Surgical Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy Electronic address
    Eur J Intern Med 24:721-8. 2013
    ..As a result, a more appropriate HSA use can be achieved maintaining the health care expenditure under control. ..
  4. ncbi Effects of granulocyte colony stimulating-factor in a rat model of acute liver injury
    P Caraceni
    Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, and Ospedale Policlinico S Orsola Malpighi, Bologna, Italy
    Dig Liver Dis 39:943-51. 2007
    ..We investigated whether different schedules of granulocyte colony stimulating-factor administration protect against experimental acute liver injury...
  5. doi The role of the endocannabinoid system in liver diseases
    Paolo Caraceni
    Department of Clinical Medicine, Center for Applied Biomedical Research C R B A, Alma Mater Studiorum University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Best Pract Res Clin Endocrinol Metab 23:65-77. 2009
    ..Thus, targeting the CB1 and CB2 receptors represents a potential therapeutic goal for the treatment of liver diseases...
  6. doi The endocannabinoid system and liver diseases
    P Caraceni
    Department of Internal Medicine, Cardioangiology, Hepatology, Alma Mater Studiorum University of Bologna, Bologna, Italy
    J Neuroendocrinol 20:47-52. 2008
    ....
  7. ncbi The nutritional status modulates preservation-reperfusion injury in rat fatty liver
    Paolo Caraceni
    Department of Internal Medicine, Cardioangiology, and Hepatology, University of Bologna, Bologna, Italy
    J Surg Res 127:190-6. 2005
    ..Thus, this study aimed to determine whether nutritional status influences preservation injury in fatty liver and whether energetic substrate supplementation, alone or with a vasodilator, is protective...
  8. doi Long-term treatment of hepatorenal syndrome as a bridge to liver transplantation
    Paolo Caraceni
    Department of Clinical Medicine, Alma Mater Studiorum University of Bologna, Italy
    Dig Liver Dis 43:242-5. 2011
    ..Terlipressin plus albumin is first-line treatment for hepatorenal syndrome (HRS). Therapy lasts from a few days to two weeks, whereas the efficacy and safety of long-term administration remain unsettled...
  9. doi Antagonism of the cannabinoid CB-1 receptor protects rat liver against ischaemia-reperfusion injury complicated by endotoxaemia
    P Caraceni
    Department of Clinical Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Gut 58:1135-43. 2009
    ..Thus, we aimed to determine the effect of the endocannabinoid CB1-receptor antagonist Rimonabant in a model of hepatic IR injury complicated by endotoxaemia...
  10. ncbi Technical aspects of portal vein arterialization for acute liver failure: from rat lab to man
    B Nardo
    Department of Surgery and Transplantations, S Orsola Malpighi Hospital, University of Bologna, Italy
    Transplant Proc 38:1195-7. 2006
    ..Furthermore, we have reported the application of PVA in patients with ALF. We herein have described the technical aspects of the PVA procedure both in preclinical models and in man...
  11. ncbi Oxidative injury in rat fatty liver exposed to ischemia-reperfusion is modulated by nutritional status
    M Domenicali
    Department of Internal Medicine, University of Bologna, Bologna, Italy Center for Applied Biomedical Research C R B A, University of Bologna, Bologna, Italy
    Dig Liver Dis 37:689-97. 2005
    ..Oxidative stress contributes to ischemia-reperfusion injury in fatty livers. This study aimed to determine whether glycogen depletion influences this oxidative injury and whether the administration of glucose can be protective...
  12. ncbi Successful treatment of CCL4-induced acute liver failure with portal vein arterialization in the rat
    B Nardo
    Department of Surgery and Transplantations, S Orsola Malpighi Hospital, University of Bologna, Italy
    Transplant Proc 38:1187-9. 2006
    ..This study sought to determine whether portal vein arterialization (PVA), which increases the oxygen supply to the liver, was protective in a rat model of liver failure...
  13. ncbi Protective effect of portal vein arterialization in acute liver failure induced by hepatectomy in normal and fatty liver rat
    B Nardo
    Department of Surgery and Transplantation, University of Bologna, Bologna, Italy
    Transplant Proc 38:3249-50. 2006
    ..We sought to determine whether an additional supply of oxygenated blood achieved by partial portal vein arterialization (PPVA) was protective on normal or fatty liver (FL) in rats with acute liver failure (ALF) induced by hepatectomy...
  14. ncbi Increased generation of reactive oxygen species in isolated rat fatty liver during postischemic reoxygenation
    B Nardo
    Dipartimento di Discipline Chirurgiche, Rianimatorie e dei Trapianti, University of Bologna, Policlinico Sant Orsola, Via Massarenti 9, 40138 Bologna, Italy
    Transplantation 71:1816-20. 2001
    ..Thus, this study aimed to compare the ROS formation that occurs during postanoxic reoxygenation in isolated normal and fatty livers...
  15. ncbi Food deprivation exacerbates mitochondrial oxidative stress in rat liver exposed to ischemia-reperfusion injury
    M Domenicali
    Dipartimento di Medicina Interna, Cardioangiologia ed Epatologia e, Rianimatorie e dei Trapianti, University of Bologna, 40138 Bologna, Italy
    J Nutr 131:105-10. 2001
    ..01). Food deprivation was associated with greater mitochondrial oxidative injury in rat livers exposed to warm ischemia-reperfusion, and the extent of oxidative damage in mitochondria increased with the length of food deprivation...
  16. ncbi Portal vein arterialization for the treatment of post resection acute liver failure in the rat
    B Nardo
    Department of Surgery and Transplantations, S Orsola Malpighi Hospital, University of Bologna, Italy
    Transplant Proc 38:1185-6. 2006
    ..Thus, this study sought to determine whether an additional supply of oxygenated blood delivered by portal vein arterialization (PVA) was protective against acute liver failure induced by hepatectomy...
  17. ncbi Autonomic dysfunction and hyperdynamic circulation in cirrhosis with ascites
    F Trevisani
    Department of Internal Medicine, Cardioangiology and Hepatology, University of Bologna, Italy
    Hepatology 30:1387-92. 1999
    ..46; P =.013). Even closer correlations were found with vagal score. AD (mainly VD) may be involved in the pathogenesis of the hyperdynamic circulatory syndrome of patients with advanced cirrhosis...
  18. ncbi Transthoracic electrical bioimpedance: a non-invasive technique for the evaluation of the haemodynamic alterations in patients with liver cirrhosis
    F Dazzani
    Department of Internal Medicine and Hepatology, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy
    Dig Liver Dis 37:786-92. 2005
    ..We, therefore, aimed to compare transthoracic electrical bioimpedance and echocardiography in the assessment of haemodynamic status in cirrhotic patients...
  19. ncbi Serum alpha-fetoprotein for diagnosis of hepatocellular carcinoma in patients with chronic liver disease: influence of HBsAg and anti-HCV status
    F Trevisani
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, University of Bologna, Italy
    J Hepatol 34:570-5. 2001
    ..It is not established whether virological status affects the efficiency of alpha-fetoprotein (AFP) as a hepatocellular carcinoma (HCC) marker among patients with chronic liver disease (CLD)...
  20. doi Hyperoxia fully protects mitochondria of explanted livers
    G Sgarbi
    Department of Biochemistry, University of Bologna, Via Irnerio, 48, 40126, Bologna, Italy
    J Bioenerg Biomembr 43:673-82. 2011
    ..Remarkably, liver perfusion with hyperoxic solutions fully preserved mitochondrial morphology and function, suggesting that perfusion of the graft with hyperoxic solution should be considered in human transplantation...
  21. ncbi Evidence of oxidative imbalance in long-term liver transplant patients
    F Trevisani
    Department of Internal Medicine, Cardioangiology and Hepatology, University of Bologna, Italy
    Dig Liver Dis 34:279-84. 2002
    ..Previous studies have provided information limited to the immediate post-operative period. It remains to be established whether this oxidative imbalance is reversed in a longer time...
  22. ncbi Portal vein arterialization: a new surgical option against acute liver failure?
    B Nardo
    Department of Surgery, Intensive Care Unit and Transplantation, University of Bologna, Bologna, Italy
    Transplant Proc 37:2544-6. 2005
    ..We believe that this novel approach, which should promote liver regeneration by providing an additional oxygen supply to the liver, may disclose a new possibility in the treatment of ALF and prompt new clinical and experimental research...
  23. ncbi The reduced tolerance of rat fatty liver to ischemia reperfusion is associated with mitochondrial oxidative injury
    Paolo Caraceni
    Department of Internal Medicine, Cardioangiology, Hepatology, University of Bologna, Bologna, Italy
    J Surg Res 124:160-8. 2005
    ....
  24. ncbi Systemic and regional hemodynamics in pre-ascitic cirrhosis: effects of posture
    Mauro Bernardi
    Semeiotica Medica, Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Alma Mater Studiorum, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    J Hepatol 39:502-8. 2003
    ..To clarify the hemodynamic pattern of pre-ascitic cirrhosis, we compared the impact of posture on systemic and regional hemodynamics of patients and healthy subjects without and with plasma volume expansion...
  25. ncbi Soluble receptor activator of nuclear factor- kappaB Ligand (sRANKL)/osteoprotegerin balance in ageing and age-associated diseases
    Lia Pulsatelli
    Laboratorio Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biogerontology 5:119-27. 2004
    ..Hence, in ageing, the sRANKL/OPG system appears to be modified, with prominent changes in circulating OPG levels; in OA and PMR, the sRANKL/OPG balance alteration was shown to be mainly due to the increase of plasma sRANKL concentration...
  26. ncbi Liver transplantation from donors aged 80 years and over: pushing the limit
    Bruno Nardo
    University of Bologna, Departement of Surgery and Transplantation, Bologna, Italy
    Am J Transplant 4:1139-47. 2004
    ..However, hepatitis C recurrence is associated with a greater mortality in patients who received octogenarian grafts raising concerns whether to allocate these livers to HCV-positive recipients...
  27. ncbi Impairment of mitochondrial oxidative phosphorylation in rat fatty liver exposed to preservation-reperfusion injury
    Paolo Caraceni
    Dipartimento di Biochimica, University of Bologna, 40138 Bologna, Italy
    J Hepatol 41:82-8. 2004
    ..As the impairment of the cellular energy metabolism contributes to the failure of fatty liver grafts after transplantation, we aimed to determine whether steatosis affects the oxidative phosphorylation activity during preservation...
  28. ncbi QT interval in patients with non-cirrhotic portal hypertension and in cirrhotic patients treated with transjugular intrahepatic porto-systemic shunt
    Franco Trevisani
    Dipartimento di Medicina Interna Cardioangiologia, Epatologia, Alma Mater Studiorum, University of Bologna, Via Massarenti, 9 40138 Bologna, Italy
    J Hepatol 38:461-7. 2003
    ..A prolonged QT interval is frequent in chronic liver disease and its aetiology remains unsettled. The study's aim was to assess the role of portal hypertension in the pathogenesis of QT prolongation...
  29. doi Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis
    Paolo Caraceni
    Dipartimento di Medicina Clinica, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Liver Int 30:816-25. 2010
    ..Thus, we aimed to assess whether circulating and hepatic endocannabinoids are upregulated in cirrhotic patients and whether their levels correlate with systemic haemodynamics and liver function...
  30. ncbi Malignant progression of a small HCC nodule: hypovascular 'early HCC' converted to hypervascular 'small HCC' within six months
    R Golfieri
    Department of Radiology, Sant Orsola Malpighi Hospital, University of Bologna, Italy
    Dig Liver Dis 39:883-90. 2007
    ....
  31. doi A fast and validated mass spectrometry method for the evaluation of human serum albumin structural modifications in the clinical field
    M Naldi
    Centro Interdipartimentale di Ricerche Biotecnologiche, Bologna, Italy
    Eur J Mass Spectrom (Chichester, Eng) 19:491-6. 2013
    ....
  32. ncbi A novel sodium overload test predicting ascites decompensation in rats with CCl4-induced cirrhosis
    Marco Domenicali
    Dipartimento di Medicina Interna, Cardioangiologia ed Epatologia, University of Bologna, 40138 Bologna, Italy
    J Hepatol 43:92-7. 2005
    ..We aimed to develop a non-invasive test to identify the initial alterations of sodium homeostasis and prospectively predict decompensation in preascitic cirrhotic rats...
  33. doi Variable activation of phosphoinositide 3-kinase influences the response of liver grafts to ischemic preconditioning
    Matteo Cescon
    Department of General Surgery and Organ Transplantation, Liver and Multiorgan Transplant Unit, Alma Mater Studiorum University of Bologna, Bologna, Italy
    J Hepatol 50:937-47. 2009
    ..Phosphoinositide-3-kinase (PI3K) is essential for IPC development in rodent livers. This work investigates whether PI3K-dependent signals might account for the inconsistent responses to IPC of transplanted human livers...
  34. doi A novel model of CCl4-induced cirrhosis with ascites in the mouse
    Marco Domenicali
    Department of Clinical Medicine, Alma Mater Studiorum University of Bologna, Azienda Ospedaliera Universitaria Policlinico S Orsola Malpighi, Via Massarenti 9, 40138 Bologna, Italy
    J Hepatol 51:991-9. 2009
    ..However, experimental models of decompensated cirrhosis have not been clearly established in mice. Thus, we aimed to set an efficient and well-tolerated protocol to induce cirrhosis in mice able to progress up to the ascitic stage...
  35. ncbi Cannabinoid type 1 receptor antagonism delays ascites formation in rats with cirrhosis
    Marco Domenicali
    Dipartimento di Medicina Clinica, Alma Mater Studiorum Universita di Bologna, Bologna, Italy
    Gastroenterology 137:341-9. 2009
    ..Whether this favors renal sodium retention and ascites formation is unknown. We determined whether cannabinoid type 1 receptor antagonism prevents sodium retention and ascites formation in preascitic cirrhotic rats...
  36. doi Effect of chronic beta-blockade on QT interval in patients with liver cirrhosis
    Andrea Zambruni
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Semeiotica Medica, Alma Mater Studiorum, Universita di Bologna, Bologna, Italy
    J Hepatol 48:415-21. 2008
    ..QT interval prolongation is frequent in cirrhosis, predicts a poor prognosis and may trigger severe ventricular arrhythmias. Our aim was to evaluate the effect of chronic beta-blockade on QT prolongation...
  37. ncbi Successful treatment of CCl4-induced acute liver failure with portal vein arterialization in the rat
    Bruno Nardo
    Department of Surgery, Intensive Care and Transplantation, University of Bologna, Bologna, Italy
    J Surg Res 135:394-401. 2006
    ..Thus, this study aimed to determine whether an additional supply of oxygenated blood achieved by portal vein arterialization (PVA) is protective in rat ALF caused by toxin administration or hepatectomy...
  38. ncbi Daily profile of circulating C-type natriuretic peptide in pre-ascitic cirrhosis and in normal subjects: relationship with renal function
    Andrea Zambruni
    Dipartimento di Medicina Interna, Cardioangiologia ed Epatologia, Alma Mater Studiorum, Universita di Bologna, Italy
    Scand J Gastroenterol 42:642-7. 2007
    ..To investigate whether the C-type natriuretic peptide (CNP) has a role in the regulation of fluid and sodium homeostasis in normal subjects and in pre-ascitic cirrhotic patients...
  39. doi Muscle circulation contributes to hyperdynamic circulatory syndrome in advanced cirrhosis
    Paolo Caraceni
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Alma Mater Studiorum Universita di Bologna, Semeiotica Medica Policlinico S Orsola, Bologna, Italy
    J Hepatol 48:559-66. 2008
    ..Thus, we assessed systemic hemodynamics and femoral artery blood flow corrected by muscle mass of the lower limb in 13 patients (Child-Pugh classes B and C) and 11 healthy controls...
  40. ncbi Cardiac electrophysiological abnormalities in patients with cirrhosis
    Andrea Zambruni
    Dipartimento di Medicina Interna, Cardioangiologia ed Epatologia, Alma Mater Studiorum Universita di Bologna, Semeiotica Medica Policlinico S Orsola Malpighi Via Albertoni, 15 40138 Bologna, Italy
    J Hepatol 44:994-1002. 2006
  41. ncbi Portal vein arterialization in a patient with acute liver failure
    Bruno Nardo
    Transplantation 79:851-2. 2005
  42. ncbi Role of p38 map kinase in glycine-induced hepatocyte resistance to hypoxic injury
    Rita Carini
    Department of Medical Sciences, University A Avogadro, Novara, Italy
    J Hepatol 46:692-9. 2007
    ..Glycine hepatoprotection is well known. However, the mechanisms involved are still poorly characterized...