Giovanni Capranico

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Development of DNA topoisomerase-related therapeutics: a short perspective of new challenges
    Giovanni Capranico
    Department of Biochemistry G Moruzzi, Alma Mater Studiorum University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Curr Med Chem Anticancer Agents 4:335-45. 2004
  2. ncbi A rational selection of drug targets needs deeper insights into general regulation mechanisms
    Giovanni Capranico
    Department of Biochemistry G Moruzzi, Alma Mater Studiorum University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Curr Med Chem Anticancer Agents 4:393-4. 2004
  3. ncbi Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells
    Andriy Khobta
    Department of Biochemistry, University of Bologna School of Pharmacy, Via Irnerio 48, 40126 Bologna, Italy
    J Mol Biol 357:127-38. 2006
  4. doi Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: activation of telomere-proximal genes by TOP1 deletion
    Luca Lotito
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    J Mol Biol 377:311-22. 2008
  5. pmc Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation
    Jessica Marinello
    Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy and CASPUR, Via dei Tizii 6, Rome 00185, Italy
    Nucleic Acids Res 41:10110-23. 2013
  6. pmc DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus
    Laura Baranello
    G Moruzzi Department of Biochemistry, University of Bologna, Bologna, Italy
    Nucleic Acids Res 38:159-71. 2010
  7. ncbi The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells
    Davide Bertozzi
    Corresponding Author G Capranico, Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Mol Cancer Ther 13:239-48. 2014
  8. pmc Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation
    Carmen Petronzi
    Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte Don Melillo, Fisciano, SA, 84084, Italy
    J Exp Clin Cancer Res 32:24. 2013
  9. ncbi The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I
    Giovanni Capranico
    Department of Biochemistry, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochimie 89:482-9. 2007
  10. doi Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: implications for physiological and therapeutic modulation of enzyme activity
    Giovanni Capranico
    G Moruzzi Department of Biochemistry, University of Bologna, Bologna, Italy
    Biochim Biophys Acta 1806:240-50. 2010

Collaborators

Detail Information

Publications18

  1. ncbi Development of DNA topoisomerase-related therapeutics: a short perspective of new challenges
    Giovanni Capranico
    Department of Biochemistry G Moruzzi, Alma Mater Studiorum University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Curr Med Chem Anticancer Agents 4:335-45. 2004
    ..Moreover, we will review novel and diverse approaches relevant to the development of new topoisomerase-related therapeutics...
  2. ncbi A rational selection of drug targets needs deeper insights into general regulation mechanisms
    Giovanni Capranico
    Department of Biochemistry G Moruzzi, Alma Mater Studiorum University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Curr Med Chem Anticancer Agents 4:393-4. 2004
    ..Until we get deeper insights into fundamental mechanisms of cellular functions, the approach to drug design and discovery will remain empirical...
  3. ncbi Early effects of topoisomerase I inhibition on RNA polymerase II along transcribed genes in human cells
    Andriy Khobta
    Department of Biochemistry, University of Bologna School of Pharmacy, Via Irnerio 48, 40126 Bologna, Italy
    J Mol Biol 357:127-38. 2006
    ....
  4. doi Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: activation of telomere-proximal genes by TOP1 deletion
    Luca Lotito
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    J Mol Biol 377:311-22. 2008
    ..As telomere-proximal regions are known to be enriched for stress-activated genes, our findings show that Top1p can optimize transcript levels for cell growth in exponentially growing cells under a synthetic medium with glucose...
  5. pmc Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation
    Jessica Marinello
    Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy and CASPUR, Via dei Tizii 6, Rome 00185, Italy
    Nucleic Acids Res 41:10110-23. 2013
    ..The results clarify molecular features of a response pathway leading to transcription-dependent genome instability and altered transcription regulation. ..
  6. pmc DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus
    Laura Baranello
    G Moruzzi Department of Biochemistry, University of Bologna, Bologna, Italy
    Nucleic Acids Res 38:159-71. 2010
    ..A changed balance of antisense transcripts and mRNAs may then lead to altered regulation of HIF-1alpha activity in human cancer cells...
  7. ncbi The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1α activity by changing miR expression patterns in human cancer cells
    Davide Bertozzi
    Corresponding Author G Capranico, Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Mol Cancer Ther 13:239-48. 2014
    ....
  8. pmc Cyclohexa-2,5-diene-1,4-dione-based antiproliferative agents: design, synthesis, and cytotoxic evaluation
    Carmen Petronzi
    Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte Don Melillo, Fisciano, SA, 84084, Italy
    J Exp Clin Cancer Res 32:24. 2013
    ..The purpose of the work is to test the ability of the compounds to induce proliferative inhibition and study the mechanisms of cell death...
  9. ncbi The effects of camptothecin on RNA polymerase II transcription: roles of DNA topoisomerase I
    Giovanni Capranico
    Department of Biochemistry, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochimie 89:482-9. 2007
    ..Here, we will briefly review relevant investigations on topoisomerase I involvement in different stages of transcription, discussing both enzyme functions and drug effects on molecular processes...
  10. doi Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: implications for physiological and therapeutic modulation of enzyme activity
    Giovanni Capranico
    G Moruzzi Department of Biochemistry, University of Bologna, Bologna, Italy
    Biochim Biophys Acta 1806:240-50. 2010
    ..That may have a considerable impact on cancer therapy development particularly for non-responsive human tumors...
  11. doi A specific transcriptional response of yeast cells to camptothecin dependent on the Swi4 and Mbp1 factors
    Luca Lotito
    G Moruzzi Department of Biochemistry, University of Bologna, Bologna, Italy
    Eur J Pharmacol 603:29-36. 2009
    ....
  12. ncbi DNA topoisomerase i as a transcription protein and a lethal cellular toxin
    Luca Lotito
    Department of Biochemistry, University of Bologna, Bologna, Italy
    Ital J Biochem 56:122-9. 2007
    ..Moreover, we will discuss recent findings on the targeting of topoisomerase I to pre-selected sites in transcribed chromatin by fusion to a sequence-specific DNA-binding protein domain...
  13. ncbi Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent
    Vincenzo Tumiatti
    Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Med Chem 52:7873-7. 2009
    ..Furthermore, 1 and 2 caused a decrease of ERK1/2 and, unlike mitonafide, inhibited ERKs phosphorylation...
  14. ncbi Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster region of the human MLL gene
    Andriy Khobta
    G Moruzzi Department of Biochemistry, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Cancer Res 64:2656-62. 2004
    ..In the studied cell models, chromatin components at the MLL BCR suggest an asymmetric organization that may influence early molecular events eventually leading to chromosomal translocations...
  15. ncbi Characterization of novel antisense HIF-1α transcripts in human cancers
    Davide Bertozzi
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    Cell Cycle 10:3189-97. 2011
    ..Altogether, our findings may suggest a novel function of 5'aHIF-1α in membrane transport that may regulate the cancer-relevant HIF-1α pathway...
  16. ncbi Intracellular distribution of beta-catenin in human medulloblastoma cell lines with different degree of neuronal differentiation
    Roberta Salaroli
    Clinical Department of Radiological and Histopathological Sciences, Bologna, Italy
    Ultrastruct Pathol 31:33-44. 2007
    ..These observations support an important functional role of WNT/beta-catenin pathway in neuronal differentiation in medulloblastoma...
  17. pmc Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism
    Simone Pieretti
    Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy
    PLoS Negl Trop Dis 7:e2012. 2013
    ..To disclose such a multitarget profile of B6, we exploited a chemical proteomics approach...
  18. ncbi Enhanced CPT sensitivity of yeast cells and selective relaxation of Ga14 motif-containing DNA by novel Gal4-topoisomerase I fusion proteins
    Marco Alessandri
    Alma Mater Studiorum University of Bologna, G Moruzzi Department of Biochemistry, Via S Giacomo 11, 40126 Bologna, Italy
    J Mol Biol 337:295-305. 2004
    ..Such hybrid Top1s may be helpful in further dissecting enzyme functions, and constitute a prototype of a site-specific DNA cutter endowed with high cell lethality...