V Capra

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. doi request reprint Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents
    Valerie Capra
    Laboratory of Molecular Pharmacology, Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy Electronic address
    Pulm Pharmacol Ther 27:10-6. 2014
  2. pmc Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation
    Valerie Capra
    Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 8:e60475. 2013
  3. pmc CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation
    Saula Ravasi
    Laboratory of Molecular Pharmacology, Section of Eicosanoid Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Respir Res 7:42. 2006
  4. ncbi request reprint Thromboxane prostanoid receptor in human airway smooth muscle cells: a relevant role in proliferation
    Valerie Capra
    Institut Féderatif de Recherche Circulation Lariboisière, Hopital Lariboisiere, 75010 Paris, France
    Eur J Pharmacol 474:149-59. 2003
  5. ncbi request reprint Molecular and functional aspects of human cysteinyl leukotriene receptors
    Valerie Capra
    Laboratory of Molecular Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Pharmacol Res 50:1-11. 2004
  6. ncbi request reprint Mutational analysis of the highly conserved ERY motif of the thromboxane A2 receptor: alternative role in G protein-coupled receptor signaling
    Valerie Capra
    Laboratory of Molecular Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Italy
    Mol Pharmacol 66:880-9. 2004
  7. ncbi request reprint Cysteinyl-leukotriene receptor antagonists: present situation and future opportunities
    V Capra
    Laboratory of Molecular Pharmacology, Section of Eicosanoid Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan, Italy
    Curr Med Chem 13:3213-26. 2006
  8. ncbi request reprint Leukotrienes as mediators of asthma
    S Nicosia
    Laboratory of Molecular Pharmacology, Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, Milan, 9 20133, Italy
    Pulm Pharmacol Ther 14:3-19. 2001

Detail Information

Publications8

  1. doi request reprint Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents
    Valerie Capra
    Laboratory of Molecular Pharmacology, Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy Electronic address
    Pulm Pharmacol Ther 27:10-6. 2014
    ....
  2. pmc Full and partial agonists of thromboxane prostanoid receptor unveil fine tuning of receptor superactive conformation and G protein activation
    Valerie Capra
    Department of Pharmacological and Biomolecular Sciences, Universita degli Studi di Milano, Milan, Italy
    PLoS ONE 8:e60475. 2013
    ..Evolutionary forces may have favored regulation mechanisms leading to low basal activity and selected against more highly active phenotypes...
  3. pmc CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation
    Saula Ravasi
    Laboratory of Molecular Pharmacology, Section of Eicosanoid Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Respir Res 7:42. 2006
    ..We used human ASMC (HASMC) to identify the signal transduction pathway(s) of the leukotriene D4 (LTD4)-induced DNA synthesis...
  4. ncbi request reprint Thromboxane prostanoid receptor in human airway smooth muscle cells: a relevant role in proliferation
    Valerie Capra
    Institut Féderatif de Recherche Circulation Lariboisière, Hopital Lariboisiere, 75010 Paris, France
    Eur J Pharmacol 474:149-59. 2003
    ..Both events were specifically inhibited by SQ29,548, independently from transactivation of the epidermal growth factor receptor and partially sensitive to pertussis toxin...
  5. ncbi request reprint Molecular and functional aspects of human cysteinyl leukotriene receptors
    Valerie Capra
    Laboratory of Molecular Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    Pharmacol Res 50:1-11. 2004
    ..Molecular cloning of different CysLT receptor subtypes will certainly foster the development of new selective antagonists based on molecular modelling studies...
  6. ncbi request reprint Mutational analysis of the highly conserved ERY motif of the thromboxane A2 receptor: alternative role in G protein-coupled receptor signaling
    Valerie Capra
    Laboratory of Molecular Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Italy
    Mol Pharmacol 66:880-9. 2004
    ....
  7. ncbi request reprint Cysteinyl-leukotriene receptor antagonists: present situation and future opportunities
    V Capra
    Laboratory of Molecular Pharmacology, Section of Eicosanoid Pharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, Milan, Italy
    Curr Med Chem 13:3213-26. 2006
    ..This review summarizes and attempts to integrate recent data on the therapeutic efficacy, effectiveness and safety of LTRAs in asthma and allergic rhinitis, and speculates on other therapeutic opportunities...
  8. ncbi request reprint Leukotrienes as mediators of asthma
    S Nicosia
    Laboratory of Molecular Pharmacology, Institute of Pharmacological Sciences, University of Milan, Via Balzaretti, Milan, 9 20133, Italy
    Pulm Pharmacol Ther 14:3-19. 2001
    ..Finally, the evidence supporting their role as asthma mediators is reviewed, including the effects of anti LT drugs (both biosynthesis inhibitors and receptor antagonists) in experimental and clinical asthma...