Research Topics
| E CapelloSummaryAffiliation: University of Genoa Country: Italy Publications
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Detail Information
Publications
Marburg type and Balò's concentric sclerosis: rare and acute variants of multiple sclerosisE Capello
Deparment of Neuroscience, Oftalmology and Genetics, University of Genoa, Via De Toni 5, I 16132 Genoa, Italy
Neurol Sci 25:S361-3. 2004..Although in some patients a favourable clinical course has been described, the poor prognosis of the majority of these cases justifies a treatment with intense immunosuppression...
Intense immunosuppression followed by autologous stem cell transplantation in severe multiple sclerosisE Capello
Department of Neurological Sciences Ophthalmology and Genetics, University of Genoa, Via De Toni 5, I 16132, Genoa, Italy
Neurol Sci 26:S200-3. 2005..These results support a role for intense immunosuppression followed by ASCT as treatment in rapidly evolving MS cases unresponsive to conventional therapies...
Autologous haematopoietic stem cell transplantation with an intermediate intensity conditioning regimen in multiple sclerosis: the Italian multi-centre experienceG L Mancardi
Department of Neuroscience, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
Mult Scler 18:835-42. 2012..The clinical outcome and the toxicity of AHSCT can be diverse, depending on the various types of conditioning protocols and on the disease phase...
Acute axonal form of Guillain-Barré syndrome in a multiple sclerosis patient: chance association or linked disorders?E Capello
Department of Neurological Sciences and Vision, University of Genoa, Genoa, Italy
Eur J Neurol 7:223-5. 2000..It remains unresolved if the association of an axonal form of GBS and MS is fortuitous or, on the contrary, is indicative of the coexistence in some individuals of common pathogenetic mechanisms...
Demyelination and axonal damage in a non-human primate model of multiple sclerosisG Mancardi
Department of Neurological Sciences and Vision, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
J Neurol Sci 184:41-9. 2001..These findings are of relevance for the development of therapies, which can protect axons and enhance their function and survival...
Restricted immune responses lead to CNS demyelination and axonal damageG Mancardi
Department of Neurological Sciences and Vision, University of Genova, Via De Toni 5, 16132, Genoa, Italy
J Neuroimmunol 107:178-83. 2000....
Autologous haematopoietic stem-cell transplantation in multiple sclerosis: benefits and risksE Capello
Department of Neuroscience, Ophthalmology and Genetics, University of Genova, Genoa, Italy
Neurol Sci 30:S175-7. 2009..The risk of mortality, which dropped in the last years to 2-3%, is still the main problem of this powerful therapy...
Tumor-like multiple sclerosis (MS) lesions: neuropathological cluesE Capello
Department of Neurological Sciences and Vision, University of Genoa, Italy
Neurol Sci 22:S113-6. 2001..These cases are characterized by a severe clinical course and a rapid clinical deterioration, only partially modified by medical treatments. Atypical severe cases, misdiagnosed as MS, can be indeed due to primary CNS vasculitis...
Association of melanoma and natalizumab therapy in the Italian MS population: a second case reportA Laroni
Multiple Sclerosis Center, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Genoa, Italy
Neurol Sci 32:181-2. 2011..Here we report a case of melanoma in a patient who developed melanoma after 77 infusions of natalizumab, without known risk factors. Pharmacovigilance programs of new drugs can help to monitor adverse events in patients at risk...
Urinary JCV-DNA testing during natalizumab treatment may increase accuracy of PML risk stratificationA Laroni
Department of Neuroscience, Ophthalmology and Genetics, University of Genova, Via De Toni 5, 16132, Genoa, Italy
J Neuroimmune Pharmacol 7:665-72. 2012..In conclusion, testing JCV-DNA in urine is complementary to testing anti-JCV antibodies in identifying patients at risk of PML...
EAE in the common marmoset Callithrix jacchusA Uccelli
Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics and Centre of Excellence for Biomedical Research, University of Genoa, Genoa, Italy
Int MS J 10:6-12. 2003....
Tremor associated with benign IgM paraproteinaemic neuropathy successfully treated with gabapentinA Saverino
Department of Neurological Sciences and Vision, University of Genoa, Genoa, Italy
Mov Disord 16:967-8. 2001..The patient reached the full dose of 1,200 mg/day of gabapentin without side effects and showed a significant therapy-related improvement of tremor and disability, as judged by the Fahn Tolosa Marin Rating Scale...
Activity, tolerability and efficacy of levetiracetam on cerebellar symptoms in multiple sclerosis patients: a pilot kinematic studyC Solaro
Center of Bioengineering, Hospital La Colletta, Arenzano, Italy
Eur J Neurol 15:619-26. 2008....
The 14-3-3 protein in multiple sclerosis: a marker of disease severityM Colucci
Department of Neuroscience, Ophthalmology and Genetic and Center of Excellence for Biomedical Research, University of Genova, Genova, Italy
Mult Scler 10:477-81. 2004..CONCLUSIONS: The immunoblot analysis of 14-3-3 protein in the CSF could be a useful marker to identify a subgroup of DD patients with high risk of developing severe disability...
Effect of glatiramer acetate on MS lesions enhancing at different gadolinium dosesM Rovaris
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
Neurology 59:1429-32. 2002..GA is effective in reducing MS activity, independent of the severity of the MRI-detectable inflammatory process...
Autologous stem cell transplantation for severe autoimmune diseases: a 10-year experienceF Gualandi
Division of Hematology and Stem Cell Transplantation Center, Azienda Ospedaliera Universitaria S Martino, Italy
Ann N Y Acad Sci 1110:455-64. 2007..The mechanism of action of this intervention remains not completely understood, as briefly discussed here...
