Affiliation: University of Rome Tor Vergata
Candi E, Cipollone R, Rivetti di Val Cervo P, Gonfloni S, Melino G, Knight R. p63 in epithelial development. Cell Mol Life Sci. 2008;65:3126-33 pubmed publisher
..In this review, we summarize the current advances that have been made in understanding the role of p63 in epidermal morphogenesis. ..
ViticchiÃ¨ G, Agostini M, Lena A, Mancini M, Zhou H, Zolla L, et al
. p63 supports aerobic respiration through hexokinase II. Proc Natl Acad Sci U S A. 2015;112:11577-82 pubmed publisher
..The Î”Np63-HK2 axis is also present in epithelial cancer cells, suggesting that Î”Np63 could participate in cancer metabolic reprogramming. ..
Smirnov A, Lena A, Cappello A, Panatta E, Anemona L, Bischetti S, et al
. ZNF185 is a p63 target gene critical for epidermal differentiation and squamous cell carcinoma development. Oncogene. 2018;: pubmed publisher
..Together, these studies reinforce that p63 is a crucial gene for maintaining epithelial tissue integrity and support the deregulation of the cell-cell adhesion programme,which plays a critical role in carcinoma development. ..
Lena A, Duca S, Novelli F, Melino S, Annicchiarico Petruzzelli M, Melino G, et al
. Amino-terminal residues of Î”Np63, mutated in ectodermal dysplasia, are required for its transcriptional activity. Biochem Biophys Res Commun. 2015;467:434-40 pubmed publisher
..Here, we characterize five p63 mutations at the 5' end of TP63 gene aiming to understand the pathogenesis of the diseases and to uncover the role of Î”Np63Î± N-terminus residues in determining its transactivation potential. ..
Panatta E, Lena A, Mancini M, Affinati M, Smirnov A, Annicchiarico Petruzzelli M, et al
. Kruppel-like factor 4 regulates keratinocyte senescence. Biochem Biophys Res Commun. 2018;499:389-395 pubmed publisher
..Our findings identify a novel regulatory loop between miR-34a and KLF4 during keratinocytes replicative senescence. This regulatory loop, beside aging, may play a role in age-related pathologies. ..
Candi E, Terrinoni A, Rufini A, Chikh A, Lena A, Suzuki Y, et al
. p63 is upstream of IKK alpha in epidermal development. J Cell Sci. 2006;119:4617-22 pubmed
..We also found that DeltaNp63 upregulates IKKalpha indirectly, through GATA-3. Our data are consistent with a role for p63 directly upstream of IKKalpha in epithelial development. ..
Mancini M, Lena A, Saintigny G, Mahé C, Di Daniele N, Melino G, et al
. MicroRNAs in human skin ageing. Ageing Res Rev. 2014;17:9-15 pubmed publisher
..Here, we will focus on the molecular mechanisms regulated by senescence-associated microRNAs and their validated targets in both keratinocytes and dermal fibroblasts. ..
Pitolli C, Pietroni V, Marekov L, Terrinoni A, Yamanishi K, Mazzanti C, et al
. Characterization of TG2 and TG1-TG2 double knock-out mouse epidermis. Amino Acids. 2017;49:635-642 pubmed publisher
..Our results confirm a key role of TG1 in skin differentiation and CE assembly and demonstrate that TG2 is not essential for CE assembly and skin formation. ..
Candi E, Smirnov A, Panatta E, Lena A, Novelli F, Mancini M, et al
. Metabolic pathways regulated by p63. Biochem Biophys Res Commun. 2017;482:440-444 pubmed publisher
..Here, we review the role of p63 isoforms, TAp63 and ?Np63, in controlling cell metabolism, focusing on their specific metabolic target genes and their physiological/functional context of action. ..