G Campiani

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. ncbi request reprint Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains
    Sandra Gemma
    Dipartimento Farmaco Chimico Tecnologico, Universita di Siena, Via Aldo Moro, 53100 Siena, Italy
    Bioorg Med Chem Lett 16:5384-8. 2006
  2. ncbi request reprint STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells
    Lisa M Greene
    School of Biochemistry and Immunology, Trinity College, Dublin 2, United Kingdom
    J Pharmacol Exp Ther 321:288-97. 2007
  3. pmc Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate
    Pradeep R Patil
    European Research Centre for Drug Discovery and Development, Department of Pharmaceutical and Applied Chemistry, University of Siena, Italy
    Malar J 10:348. 2011
  4. ncbi request reprint Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties
    G Campiani
    Dipartimento Farmaco Chimico Tecnologico DFCT, Universita degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy
    J Med Chem 44:4501-4. 2001
  5. ncbi request reprint Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR)
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy
    J Med Chem 45:4276-81. 2002
  6. ncbi request reprint Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico DFCT, Universita degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy
    Curr Pharm Des 9:599-625. 2003
  7. ncbi request reprint Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico, Universita di Siena, Via Aldo Moro, 53100 Siena, Italy
    J Med Chem 46:3822-39. 2003
  8. ncbi request reprint Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro and European Research Centre for Drug Discovery and Development, Universita degli Studi di Siena, 53100 Siena, Italy
    J Med Chem 47:143-57. 2004
  9. ncbi request reprint Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro, and European Research Centre for Drug Discovery and Development, Universita di Siena, 53100 Siena, Italy
    J Med Chem 48:1705-8. 2005
  10. ncbi request reprint Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro, and European Research Centre for Drug Discovery and Development NatSynDrugs, Universita di Siena, 53100 Siena, Italy
    J Med Chem 48:1919-29. 2005

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains
    Sandra Gemma
    Dipartimento Farmaco Chimico Tecnologico, Universita di Siena, Via Aldo Moro, 53100 Siena, Italy
    Bioorg Med Chem Lett 16:5384-8. 2006
    ..These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs...
  2. ncbi request reprint STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells
    Lisa M Greene
    School of Biochemistry and Immunology, Trinity College, Dublin 2, United Kingdom
    J Pharmacol Exp Ther 321:288-97. 2007
    ..Together, these findings highlight the potential clinical benefits in simultaneously targeting the microtubules and the Bcr-Abl oncoprotein in STI-571-sensitive and -resistant CML cells...
  3. pmc Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate
    Pradeep R Patil
    European Research Centre for Drug Discovery and Development, Department of Pharmaceutical and Applied Chemistry, University of Siena, Italy
    Malar J 10:348. 2011
    ..Here, this property is further explored using a new panel of ICAM-1-binding patient isolates of P. falciparum to ascertain if (+)-EGCG might be effective as a broad spectrum inhibitor of ICAM-1-based cytoadherence...
  4. ncbi request reprint Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties
    G Campiani
    Dipartimento Farmaco Chimico Tecnologico DFCT, Universita degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy
    J Med Chem 44:4501-4. 2001
    ....
  5. ncbi request reprint Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral type benzodiazepine receptors (PBR)
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy
    J Med Chem 45:4276-81. 2002
    ..Several compounds, differently substituted at C-7, were used as molecular yardsticks to probe the spatial dimension of the lipophilic pocket L4 in the receptor binding site...
  6. ncbi request reprint Neuronal high-affinity sodium-dependent glutamate transporters (EAATs): targets for the development of novel therapeutics against neurodegenerative diseases
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico DFCT, Universita degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy
    Curr Pharm Des 9:599-625. 2003
    ....
  7. ncbi request reprint Synthesis and pharmacological evaluation of potent and highly selective D3 receptor ligands: inhibition of cocaine-seeking behavior and the role of dopamine D3/D2 receptors
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico, Universita di Siena, Via Aldo Moro, 53100 Siena, Italy
    J Med Chem 46:3822-39. 2003
    ....
  8. ncbi request reprint Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro and European Research Centre for Drug Discovery and Development, Universita degli Studi di Siena, 53100 Siena, Italy
    J Med Chem 47:143-57. 2004
    ..In conclusion, the pharmacological profile of 9d proved better than clozapine and olanzapine, making this compound a potential clinical candidate...
  9. ncbi request reprint Novel atypical antipsychotic agents: rational design, an efficient palladium-catalyzed route, and pharmacological studies
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro, and European Research Centre for Drug Discovery and Development, Universita di Siena, 53100 Siena, Italy
    J Med Chem 48:1705-8. 2005
    ..5a was active on conditioned avoidance response at 0.56 mg/kg, it had low cataleptic potential and proved to be better than ST1899, clozapine, and olanzapine, representing a new clinical candidate...
  10. ncbi request reprint Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro, and European Research Centre for Drug Discovery and Development NatSynDrugs, Universita di Siena, 53100 Siena, Italy
    J Med Chem 48:1919-29. 2005
    ..The novel inhibitors, bearing postulated key features, validated the hypothesis of the presence of extra interaction sites within the hBuChE active site gorge...
  11. doi request reprint Design, synthesis, and structure-activity relationship studies of 4-quinolinyl- and 9-acrydinylhydrazones as potent antimalarial agents
    Caterina Fattorusso
    J Med Chem 51:1333-43. 2008
    ..The mechanism of action of the novel compounds was investigated and their in vivo activity was assessed...
  12. ncbi request reprint Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy
    Curr Pharm Des 8:615-57. 2002
    ..Starting from the first generation, this review will focus on the second generation NNRTIs dealing with the recent and most interesting published results, highlighting the guidelines for the development of a third generation of NNRTIs...
  13. ncbi request reprint Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies
    G Campiani
    Dipartimento di Scienze Farmaceutiche, Facolta di Farmacia, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
    J Med Chem 42:4362-79. 1999
    ..None of the tested compounds showed in vivo anxiolytic-like activity, but potential analgesic-like properties have been possibly disclosed for this new class of 5-HT(3) receptor agonists...
  14. ncbi request reprint Pyrrolo[1,3]benzothiazepine-based atypical antipsychotic agents. Synthesis, structure-activity relationship, molecular modeling, and biological studies
    Giuseppe Campiani
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Aldo Moro, 53100 Siena, Italy
    J Med Chem 45:344-59. 2002
    ..The molecular structure determination of the enantiomers of 5 by X-ray diffraction and molecular modeling is reported...
  15. ncbi request reprint Pyrrolobenzoxazepinone derivatives as non-nucleoside HIV-1 RT inhibitors: further structure-activity relationship studies and identification of more potent broad-spectrum HIV-1 RT inhibitors with antiviral activity
    G Campiani
    Dipartimento di Scienze Farmaceutiche, Facolta di Farmacia, Universita degli Studi di Salerno, Via Ponte Don Melillo, 84084 Fisciano SA, Italy
    J Med Chem 42:4462-70. 1999
    ....
  16. ncbi request reprint Non-nucleoside HIV-1 reverse transcriptase inhibitors: synthesis and biological evaluation of novel quinoxalinylethylpyridylthioureas as potent antiviral agents
    G Campiani
    Dipartimento di Scienze Farmaceutiche, Facolta di Farmacia, Universita degli Studi di Salerno, Fisciano Salerno, Italy
    Antivir Chem Chemother 11:141-55. 2000
    ..Moreover, 6-FQXPT showed synergistic antiviral activity with zidovudine...
  17. ncbi request reprint Quinoxalinylethylpyridylthioureas (QXPTs) as potent non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors. Further SAR studies and identification of a novel orally bioavailable hydrazine-based antiviral agent
    G Campiani
    Dipartimento di Scienze Farmaceutiche, Facolta di Farmacia, Universita degli Studi di Salerno, Fisciano, Italy
    J Med Chem 44:305-15. 2001
    ..Replacing the ethylthioureidic moiety with a hydrazine linker led to a new antiviral lead, offering promising pharmacological and pharmacokinetic properties in terms of antiviral activity and oral bioavailability...
  18. ncbi request reprint Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors
    Luisa Savini
    Dipartimento Farmaco Chimico Tecnologico, Universita di Siena, Via Aldo Moro, 53100 Siena, Italy
    J Med Chem 46:1-4. 2003
    ..The nitrogen-containing homobivalent ligands 3e,g and the sulfur-containing 3h validated the hypothesis of extra sites of interaction in the AChE and BuChE active site gorges...
  19. ncbi request reprint Development of piperazine-tethered heterodimers as potent antimalarials against chloroquine-resistant P. falciparum strains. Synthesis and molecular modeling
    Sandra Gemma
    European Research Centre for Drug Discovery and Development, Universita di Siena, Via Aldo Moro, 53100 Siena, Italy
    Bioorg Med Chem Lett 17:3535-9. 2007
    ..Computational studies revealed that the activity is likely due to the ability of the compounds to assume a multisite iron coordinating geometry...
  20. doi request reprint Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors
    Stefania Butini
    European Research Centre for Drug Discovery and Development NatSynDrugs, Universita di Siena, Siena, Italy
    J Med Chem 51:3154-70. 2008
    ..A number of SAR trends were identified, and the multisite inhibitors 3a and 3d were found to be the most potent inhibitors of hBuChE and hAChE known to date...
  21. ncbi request reprint Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites
    Sandra Gemma
    Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro, Universita di Siena, 53100 Siena, Italy
    J Med Chem 49:3421-5. 2006
    ..Compounds 5a-c show a markedly improved biological profile relative to tacrine and huperzine A...
  22. doi request reprint Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity
    Stefania Butini
    European Research Centre for Drug Discovery and Development NatSynDrugs, Via Aldo Moro 2, 53100 Siena, Italy
    Bioorg Med Chem Lett 18:5213-6. 2008
    ..Analogues 3i,j and 3l,m were identified as promising hits and may pave the way for the development of a new series of tacrine based enzyme selective hChEIs...
  23. doi request reprint Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations
    Stefania Butini
    Dipartimento Farmaco Chimico Tecnologico, Universita di Siena, Via Aldo Moro 2, 53100 Siena, Italy
    J Med Chem 52:1224-8. 2009
    ..For the novel compounds (S)-(+)-5 and (S)-(-)-7, a clear-cut stereoselective mechanism of enzyme inhibition was found. Molecular modeling studies were performed for revealing the underpinnings of this behavior...
  24. ncbi request reprint Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase
    L Savini
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via Aldo Moro, 53100, Siena, Italy
    Bioorg Med Chem Lett 11:1779-82. 2001
    ..The syntheses of these materials together with the results of AChE/BuChE inhibition assays are detailed...
  25. ncbi request reprint Diltiazem-like calcium entry blockers: a hypothesis of the receptor-binding site based on a comparative molecular field analysis model
    F Corelli
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Italy
    J Med Chem 40:125-31. 1997
    ....
  26. ncbi request reprint The interactions of the 5-HT3 receptor with quipazine-like arylpiperazine ligands: the journey track at the end of the first decade of the third millennium
    Andrea Cappelli
    Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Universita di Siena, Via A Moro, 53100 Siena, Italy
    Curr Top Med Chem 10:504-26. 2010
    ..The discussion is focused mainly on the most significant structure-affinity relationships emerged in the progress of the work and shows how the original ideas have evolved in the recent years...
  27. doi request reprint 1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators
    Stefania Butini
    European Research Centre for Drug Discovery and Development NatSynDrugs, Banchi di Sotto 55, 53100 Siena, Italy
    J Med Chem 51:6614-8. 2008
    ....
  28. doi request reprint Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors
    Stefania Butini
    European Research Centre for Drug Discovery and Development, Universita di Siena, 53100 Siena, Italy
    J Med Chem 53:4803-7. 2010
    ....
  29. ncbi request reprint Design and synthesis of potent antimalarial agents based on clotrimazole scaffold: exploring an innovative pharmacophore
    Sandra Gemma
    Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Universita di Siena, Via Aldo Moro, 53100 Siena, Italy
    J Med Chem 50:595-8. 2007
    ..This study allowed us to discover compounds characterized by a high in vitro potency, particularly against Pf CQ-resistant strains selectively targeting free heme, which are easy to synthesize by low-cost synthetic strategies...
  30. doi request reprint Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization
    Stefania Butini
    European Research Centre for Drug Discovery and Development, 53100 Siena, Italy
    J Med Chem 52:6946-50. 2009
    ..In von Bezold-Jarisch reflex test 3a-c were partial agonists while 3i was a full agonist. Preliminary pharmacokinetic studies indicated that 3a is a brain penetrating agent...
  31. doi request reprint Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies
    Sandra Gemma
    European Research Centre for Drug Discovery and Development, Universita di Siena, Italy
    Bioorg Med Chem 17:6063-72. 2009
    ..Further screening allowed the identification of very potent antitubercular agents. Compound 4c was also tested in a time-course experiment and against mtb clinical isolates, displaying interesting results...
  32. doi request reprint Synthesis of dihydroplakortin, 6-epi-dihydroplakortin, and their C10-desethyl analogues
    Sandra Gemma
    Dipartimento Farmaco Chimico Tecnologico DFCT, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    J Org Chem 75:2333-40. 2010
    ..Homologation of the aldehyde resulting from diol cleavage through a Wittig-based strategy gave access to the ester-containing lateral chain at C3...
  33. doi request reprint An efficient approach to chiral C8/C9-piperazino-substituted 1,4-benzodiazepin-2-ones as peptidomimetic scaffolds
    Stefania Butini
    European Research Centre for Drug Discovery and Development NatSynDrugs, University of Siena, Banchi di Sotto 55, 53100 Siena, Italy
    J Org Chem 73:8458-68. 2008
    ....
  34. doi request reprint Pyrroloquinoxaline hydrazones as fluorescent probes for amyloid fibrils
    Sandra Gemma
    European Research Centre for Drug Discovery and Development NatSynDrugs, University of Siena, Via Aldo Moro, 53100, Siena, Italy
    Org Biomol Chem 9:5137-48. 2011
    ..Moreover, their experimentally proven ability to cross the blood-brain barrier in mouse opens the possibility of developing these compounds as potential amyloid imaging agents for in vivo applications...
  35. ncbi request reprint Unexpected formation of hydroxybiphenylmethane derivatives and some new observations on Labat test
    Gagan Kukreja
    Dipartimento Farmaco Chimico Tecnologico, Via Aldo Moro, and European Research Centre for Drug Discovery and Development, Universita di Siena, 53100 Siena, Italy
    Nat Prod Res 20:1150-4. 2006
    ..Some new interesting observations of Labat test on colorimetric detection of bichalconyloxy, bichalconyl and biflavonylmethanes having oxygenated ortho positions are presented...
  36. doi request reprint Combining 4-aminoquinoline- and clotrimazole-based pharmacophores toward innovative and potent hybrid antimalarials
    Sandra Gemma
    European Research Centre for Drug Discovery and Development and Dipartimento Farmaco Chimico Tecnologico, Universita di Siena, Via Aldo Moro, 53100 Siena, Italy
    J Med Chem 52:502-13. 2009
    ..Among the compounds synthesized, 4g was active in vivo against P. chabaudi and P. berghei after oral administration and, possessing promising pharmacokinetic properties, it is a candidate for further preclinical development...
  37. ncbi request reprint Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2
    Anne Frandsen
    Biostructural Research, Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK 2100, Copenhagen Ø, Denmark
    Mol Pharmacol 67:703-13. 2005
    ..Although it clearly controls selectivity, mutation of this residue alone is insufficient to explain agonist-induced conformational rearrangements occurring in this variant...
  38. pmc Effects of drug resistance mutations L100I and V106A on the binding of pyrrolobenzoxazepinone nonnucleoside inhibitors to the human immunodeficiency virus type 1 reverse transcriptase catalytic complex
    Giada A Locatelli
    Istituto di Genetica Molecolare IGM CNR, Consiglio Nazionale delle Ricerche, 27100 Pavia, Italy
    Antimicrob Agents Chemother 48:1570-80. 2004
    ..This latter mutation also caused a severe reduction in the catalytic efficiency of the RT. These results provide a correlation between the efficiency of nucleotide utilization by RT and its resistance to PBO inhibition...
  39. ncbi request reprint Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines
    Jude M Mulligan
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Mol Pharmacol 70:60-70. 2006
    ..The ability of PBOX-6 to bind tubulin and cause microtubule depolymerization confirms it as a novel candidate for antineoplastic therapy...
  40. ncbi request reprint Pyrrolo[1,5]benzoxa(thia)zepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target
    Margaret M Mc Gee
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Med Chem 48:4367-77. 2005
    ..Interestingly, compound 6 displayed cytotoxic activity against a panel of human tumor cell lines but demonstrated negligible toxicity in vivo with no effect on the animals' hematology parameters...
  41. doi request reprint Clotrimazole scaffold as an innovative pharmacophore towards potent antimalarial agents: design, synthesis, and biological and structure-activity relationship studies
    Sandra Gemma
    Universita di Siena, Sienna, Italy
    J Med Chem 51:1278-94. 2008
    ..Compounds 2, 4e, and 4n exhibited in vivo activity against P. chabaudi after oral administration and thus represent promising antimalarial agents for further preclinical development...
  42. ncbi request reprint Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663
    Giovanni Maga
    Istituto di Genetica Molecolare, CNR Pavia, via Abbiategrasso 207, 27100 Pavia, Italy
    Biochemistry 44:9637-44. 2005
    ..A thorough molecular modeling study was carried out to explain the molecular basis of NS3h inhibition by QU663. The resulting three-dimensional interaction model is discussed...
  43. ncbi request reprint Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity
    Caterina Fattorusso
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    J Med Chem 48:7153-65. 2005
    ..Among the pyrrolobenzoxazepines investigated, 15c appeared to be the most promising NNRTI of the series characterized by potent antiviral activity, broad spectrum, and low cytotoxicity. 15c showed synergistic antiviral activity with AZT...
  44. ncbi request reprint Endoperoxide derivatives from marine organisms: 1,2-dioxanes of the plakortin family as novel antimalarial agents
    Caterina Fattorusso
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    J Med Chem 49:7088-94. 2006
    ....
  45. ncbi request reprint Conformational flexibility in the peripheral site of Torpedo californica acetylcholinesterase revealed by the complex structure with a bifunctional inhibitor
    Jacques Ph Colletier
    Laboratoire de Biophysique Moleculaire, Institut de Biologie Structurale, 38027 Grenoble, France
    J Am Chem Soc 128:4526-7. 2006
    ..The observed conformational flexibility highlights the dynamic nature of protein structures and is of importance for structure-based drug design...
  46. ncbi request reprint The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo
    Lisa M Greene
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    Oncol Rep 14:1357-63. 2005
    ..5 mg/kg) significantly inhibited tumour growth in vivo in a mouse mammary carcinoma model (p=0.04, n=5, Student's t-test). Thus, PBOX-6 could be a promising anti-cancer agent for both hormone-dependent and -independent breast cancers...
  47. ncbi request reprint ST2472: a new potential antipsychotic with very low liability to induce side-effects
    Maria A Stasi
    Sigma Tau Industrie Farmaceutiche Riunite S p A, Pomezia, Rome, Italy
    Int J Neuropsychopharmacol 11:309-19. 2008
    ..In conclusion, ST2472 seems to be an antipsychotic with lower liability to produce side-effects than other antipsychotics, such as haloperidol, risperidone, olanzapine and clozapine, which were evaluated as reference drugs...
  48. doi request reprint Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants
    Samantha Zanoli
    Institute of Molecular Genetics, IGM CNR, via Abbiategrasso 207, I 27100 Pavia, Italy
    Biochem Pharmacol 76:156-68. 2008
    ..Molecular modeling and docking studies provided an explanation for this correlation at the structural level...
  49. ncbi request reprint BubR1 is required for a sustained mitotic spindle checkpoint arrest in human cancer cells treated with tubulin-targeting pyrrolo-1,5-benzoxazepines
    Lisa M Greene
    School of Biochemistry and Immunology, Trinity College, Dublin 2, United Kingdom
    Mol Pharmacol 73:419-30. 2008
    ..Taken together, these results suggest that BubR1 contributes to the mitotic checkpoint induced by the PBOXs...
  50. ncbi request reprint Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation o
    Margaret M Mc Gee
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Pharmacol Exp Ther 310:1084-95. 2004
    ..Collectively, these findings identify Bcl-2 phosphorylation and inactivation as a critical step in the apoptotic pathway induced by PBOX-6 and highlight its potential as an effective antileukemic agent...
  51. ncbi request reprint Caspase-3 is not essential for DNA fragmentation in MCF-7 cells during apoptosis induced by the pyrrolo-1,5-benzoxazepine, PBOX-6
    Margaret M Mc Gee
    Biochemistry Department, Trinity College, 2, Dublin, Ireland
    FEBS Lett 515:66-70. 2002
    ..This study suggests that caspase-3 is not necessarily essential for DNA fragmentation and the morphological changes associated with apoptosis...
  52. ncbi request reprint Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor
    David G Lloyd
    Department of Biochemistry, Trinity College Dublin, Dublin 2, Ireland
    J Med Chem 47:5612-5. 2004
    ..The effect of functional group substitution on the benzoxepin scaffold is explored through a brief computational structure-activity relationship investigation with molecular simulation...
  53. ncbi request reprint Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells
    Margaret M Mc Gee
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Biol Chem 277:18383-9. 2002
    ..JIP-1 specifically scaffolds JNK, MKK7, and members of the mixed-lineage kinase (MLK) family, implicating these kinases upstream of JNK in the apoptotic pathway induced by PBOX-6 in K562 cells...
  54. doi request reprint A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin
    Navin K Verma
    Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Dublin, Ireland
    J Mol Med (Berl) 86:457-69. 2008
    ..Novel microtubule-targeting effects of PBOX-15 can possibly open new horizons in the treatment of overactive inflammatory conditions as well as cancer and cancer metastatic spreading...