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Genomes and Genes | L CalzaSummaryAffiliation: University of Bologna Country: Italy Publications
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Publications
[SARS: a new emergency in the world health]Leonardo Calza
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, Università Alma Mater Studiorum, Policlinico S Orsola, Bologna
Recenti Prog Med 94:284-94. 2003....
Transient reversal of HIV-associated motor neuron disease following the introduction of highly active antiretroviral therapyL Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
J Chemother 16:98-101. 2004..A case of MND in a male HIV-infected patient with significant but transient reversal of neurological symptoms after the use of protease inhibitor-containing antiretroviral regimen is described...
Dyslipidaemia associated with antiretroviral therapy in HIV-infected patientsLeonardo Calza
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
J Antimicrob Chemother 53:10-4. 2004..Lipid-lowering therapy is often required with statins or fibrates. The choice of hypolipidaemic drugs should take into account potential pharmacological interactions with antiretroviral agents...
Human immunodeficiency virus and hepatitis C virus coinfection: epidemiology, natural history, therapeutic options and clinical managementG Verucchi
Dept of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, via G Massarenti 11, I 40138, Bologna, Italy
Infection 32:33-46. 2004..Available data show that the sustained virological response rates in coinfected persons treated with standard IFN plus ribavirin range from 18-40%, and several studies with pegylated IFN plus ribavirin are ongoing...
Infective endocarditis: a review of the best treatment optionsLeonardo Calza
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Hospital, via G Massarenti 11, I 40138 Bologna, Italy
Expert Opin Pharmacother 5:1899-916. 2004..This review should help redefine the best therapeutic and preventive strategies against infective endocarditis...
Disseminated cutaneous leishmaniasis after visceral disease in a patient with AIDSLeonardo Calza
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, St Orsola Hospital, via G Massarenti 11, I 40138 Bologna, Italy
J Am Acad Dermatol 50:461-5. 2004..The severe concurrent immunosuppression probably played an essential role in leading to this atypical cutaneous form, characterized by diffuse, nonulcerated, nonscabby maculopapular lesions...
Legionnaires' disease associated with macular rash: two casesLeonardo Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Italy
Acta Derm Venereol 85:342-4. 2005..Two exceptional cases of Legionella pneumonia complicated by diffuse, macular rash in two adult women are described, in association with severe peripheral polyneuropathy and flaccid quadriplegia in one case...
Substitution of nevirapine or efavirenz for protease inhibitor versus lipid-lowering therapy for the management of dyslipidaemiaLeonardo Calza
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Hospital, Bologna, Italy
AIDS 19:1051-8. 2005..To evaluate simplified protease inhibitor (PI)-sparing antiretroviral treatment versus lipid-lowering therapy for the management of highly active antiretroviral therapy (HAART)-induced hyperlipidaemia...
[Tick-borne infections]Leonardo Calza
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Policlinico S Orsola, Alma Mater Studiorum Università, Bologna
Recenti Prog Med 95:403-13. 2004..This article reviews the epidemiology, microbiology, clinical manifestation, diagnosis and treatment of the major tick-borne infectious diseases in the United States and Europe...
Hyperlactataemia and lactic acidosis in HIV-infected patients receiving antiretroviral therapyLeonardo Calza
Section of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Bologna Alma Mater Studiorum, S Orsola Hospital, via G Massarenti 11, 40138, Bologna, Italy
Clin Nutr 24:5-15. 2005....
Triiodothyronine administration ameliorates the demyelination/remyelination ratio in a non-human primate model of multiple sclerosis by correcting tissue hypothyroidismG D'Intino
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy
J Neuroendocrinol 23:778-90. 2011..We therefore suggest that thyroid hormone treatment improves myelin sheath morphology in marmoset EAE, by correcting the dysfunction of thyroid hormone cellular effectors...
Nerve growth factor in the central nervous system: more than neuron survivalL Calza
Dep of Veterinary Morphophysiology and Animal Production DIMORFIPA, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell Emilia, Italy
Arch Ital Biol 141:93-102. 2003
Endogenous stem and precursor cells for demyelinating diseases: an alternative for transplantation?G D'Intino
ASC Lab, DIMORFIPA, University of Bologna, Italy
Neurol Res 28:513-7. 2006..TH is in fact known to be a key signal in brain development, oligodendrocyte development and myelin protein gene expression regulation...
The use of efavirenz as a part of late rescue antiretroviral treatmentR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Bologna, Italy
HIV Clin Trials 2:413-20. 2001..Because rescue antiretroviral strategies are increasingly needed, patients' response to a late salvage treatment including efavirenz plus a novel protease inhibitor (PI), with or without at least one novel nucleoside analogue, was assessed...
Cardiovascular risk factors and ultrasound evaluation of carotid atherosclerosis in patients with HIV-1 infectionL Calza
Department of Internal Medicine, Geriatrics and Nephrologic Diseases, Section of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Int J STD AIDS 20:683-9. 2009....
Changes in brain cholinergic markers and spatial learning in old galanin-overexpressing miceS Pirondi
Department of Veterinary Morphophysiology and Animal Production, University of Bologna, Bologna 40064, Italy
Brain Res 1138:10-20. 2007..These data suggest that galanin overexpression further accentuates the age-related decline of the cholinergic system activity in male mice, resulting in impairment of water maze performance in old animals...
[Hyperlactacidemia during antiretroviral therapy: frequency and clinical-therapeutic correlations]R Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, Universita degli Studi di Bologna, Alma Mater Studiorum, Policlinico S. Orsola, Bologna, Italy
Infez Med 14:33-6. 2006..Our case-control study on an extensive, single centre population treated for HIV infection provides novel insights on these emerging issues, reported and discussed on the basis of the most recently published findings...
HIV disease among immigrants coming to Italy from outside of the European Union: a case-control study of epidemiological and clinical featuresR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, S. Orsola Hospital, Italy
Epidemiol Infect 127:527-33. 2001..0001), and the shorter mean duration of antiretroviral treatment (11.1 +/- 2.2 months of immigrants vs. 16.2 +/- 6.7 months of controls; P < 0.0001)...
Role of gancyclovir and HAART administration in the treatment of a rare complication of HIV disease: cytomegalovirus-associated Guillain-Barré syndromeL Calza
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
J Chemother 13:575-7. 2001....
Rosuvastatin for the treatment of hyperlipidaemia in HIV-infected patients receiving protease inhibitors: a pilot studyLeonardo Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, Alma Mater Studiorum University of Bologna, S. Orsola Hospital, Bologna, Italy
AIDS 19:1103-5. 2005..01). In our small pilot study, rosuvastatin was found to be effective for the treatment of PI-associated hyperlipidaemia, in association with a favourable tolerability profile, without significant clinical or laboratory adverse events...
Another emerging event occurring during HIV infection treated with any antiretroviral therapy: frequency and role of gynecomastiaR Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, , Azienda Ospedaliera di Bologna, Policlinico S Orsola-Malpighi, Bologna, Italy
Infez Med 12:51-9. 2004..The frequent association with metabolic abnormalities suggests some common ethiologic pathway with other HAART-related disturbances...
Prevalence and virologic consequences of HIV-1 genotype mutations detected in a cohort of 161 Italian patients receiving a nelfinavir-based highly active antiretroviral therapyL Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
J Chemother 15:165-72. 2003....
Efficacy and tolerability of a fosamprenavir-ritonavir-based versus a lopinavir-ritonavir-based antiretroviral treatment in 82 therapy-naïve patients with HIV-1 infectionL Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Hospital, Bologna, Italy
Int J STD AIDS 19:541-4. 2008..5% vs. 25.6% and 69.8% vs. 43.6%, respectively; P < 0.01). In subjects with virological failure, no viral protease resistance mutations were detected by genotype analysis...
First-line efavirenz versus lopinavir-ritonavir-based highly active antiretroviral therapy for naive patientsRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna 'Alma Mater Studiorum, S. Orsola Hospital, Bologna, Italy
AIDS 18:2331-3. 2004..Randomized studies comparing these two recommended first-line treatments are warranted, particularly from a pharmacoeconomic viewpoint...
[HIV genotypic mutation selectively induced by the protease inhibitor nelfinavir at codon 30. Case series and consequences for antiretroviral management]Roberto Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, , Azienda Ospedaliera di Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy
Infez Med 10:151-6. 2002....
[HIV infection and AIDS in advanced age. Epidemiological and clinical issues, and therapeutic and management problems]R Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, Universita degli Studi Alma Mater, Policlinico S.Orsola-Malpighi, Bologna, Italy
Infez Med 12:152-73. 2004....
A single prenatal exposure to the endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin alters developmental myelination and remyelination potential in the rat brainM Fernandez
BioPharmaNet DIMORFIPA, University of Bologna, Ozzano Emilia, Bologna, Italy
J Neurochem 115:897-909. 2010..TCDD impairs neurosphere proliferation and retards CNPase-positive cell generation from adult neurospheres...
Gynecomastia associated with highly active antiretroviral therapyR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
Ann Pharmacother 35:438-9. 2001..To report four cases of HIV-associated gynecomastia diagnosed during treatment with nucleoside analogs with or without protease inhibitors...
The galanin receptor 2/3 agonist Gal2-11 protects the SN56 cells against beta-amyloid 25-35 toxicityS Pirondi
DIMORFIPA, University of Bologna, Bologna, Italy
J Neurosci Res 88:1064-73. 2010..These findings indicate that the galanin 2/3 agonist Gal2-11 protects SN56 cholinergic cells from beta-amyloid(25-35)-induced cell death and that this action is mediated by an early reduction of caspase-3 expression...
True gynecomastia in congenitally HIV-infected children treated with antiretroviral agentsR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
J Chemother 16:303-5. 2004..We report the first two cases of true gynecomastia observed in prepubertal congenitally-infected boys, and clinical, antiretroviral, metabolic, hormonal, virological, and immunological aspects...
Abacavir-induced reaction with fever and severe skin rash in a patient tested human leukocyte antigen-B*5701 negativeL Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Int J STD AIDS 20:276-7. 2009..Similar reports suggest that not all severe abacavir-induced adverse events occur as a result of classic hypersensitivity reactions, and can present also in HLA-B*5701-negative patients...
Dual nucleoside analogue treatment in the era of highly active antiretroviral therapy (HAART): a single-centre cross-sectional surveyR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
J Antimicrob Chemother 48:299-302. 2001....
Silent oophoritis due to cytomegalovirus in a patient with advanced HIV diseaseR Manfredi
Department of Clinical and Experimental Medicine, Marcello Malpighi, University of Bologna, Italy
Int J STD AIDS 11:410-2. 2000..This unusual case report is discussed with a review of the literature dealing with CMV involvement of genital organs in the immunocompromised host, and in patients with HIV infection and AIDS...
Stenotrophomonas (Xanthomonas) maltophilia as an emerging opportunistic pathogen in association with HIV infection: a 10-year surveillance studyL Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna, S Orsola Hospital, via G Massarenti 11, I 40138 Bologna, Italy
Infection 31:155-61. 2003..At present very limited information is available concerning its clinical significance in the setting of HIV infection...
Prevalence of diabetes mellitus, hyperinsulinaemia and metabolic syndrome among 755 adult patients with HIV-1 infectionL Calza
Department of Internal Medicine, Geriatrics and Nephrologic Diseases, Section of Infectious Diseases, S Orsola Malpighi Hospital, Alma Mater Studiorum, University of Bologna, Bologna, Italy
Int J STD AIDS 22:43-5. 2011..5% and 9.1%, respectively. A longer exposure to antiretroviral therapy and a diagnosis of lipodystrophy syndrome were significantly associated with both metabolic disturbances...
Measles outbreak in the city of Bologna, December 2007 to May 2008L Calza
Department of Internal Medicine, University of Bologna, S Orsola Hospital, Bologna, Italy
Infez Med 17:28-32. 2009..Orsola Hospital in Bologna in the northern Italian region of Emilia Romagna between December 2007 and May 2008...
Atypical progressive multifocal leukoencephalopathy in HIV with a high CD4 count: the use of magnetic resonance imaging plus spectrometry studiesR Manfredi
Department of Internal Medicine, Aging, and Nephrologic Diseases, Division of Infectious Diseases, Alma Mater Studiurum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Int J STD AIDS 23:e35-8. 2012....
Epidemiological, clinical and therapeutic features of AIDS-related Mycobacterium kansasii infection during the HIV pandemic: an 11-year follow-up studyR Manfredi
Division of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Bologna, Alma Mater Studiorum, Bologna, Italy
HIV Med 5:431-6. 2004..Optimal diagnosis and timely treatment of atypical mycobacteriosis, and especially Mycobacterium kansasii disease, remain a serious challenge for clinicians engaged in the management of the immunocompromised host...
Disseminated histoplasmosis with atypical cutaneous lesions in an Italian HIV-infected patient: another autochtonous caseL Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna, S Orsola Hospital, Bologna, Italy
HIV Med 4:145-8. 2003..Our patient represents the fifth autochtonous case of AIDS-associated histoplasmosis described in Italy...
Ex vivo study of dentate gyrus neurogenesis in human pharmacoresistant temporal lobe epilepsyM Paradisi
BioPharmaNet DIMORFIPA, and Department of Histology, Embryology and Applied Biology, University of Bologna, Via Tolara di Sopra 50, Bologna, Italy
Neuropathol Appl Neurobiol 36:535-50. 2010....
Lack of change in the distribution of AIDS-defining opportunistic diseases and the related degree of immunodeficiency during the periods before and after the introduction of highly active antiretroviral therapyR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
Eur J Clin Microbiol Infect Dis 20:410-3. 2001..Even in recent years, the large majority of patients newly diagnosed with AIDS have not been able to take advantage of HAART prior to diagnosis of their disease...
Carpal tunnel syndrome in HIV-infected patients treated with highly active antiretroviral therapy: other case reportsR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
Rheumatol Int 21:81-3. 2001..In our patients, carpal tunnel syndrome occurred in apparent absence of all presumed risk factors of this disease and metabolic abnormalities potentially related to HIV protease inhibitor administration...
Pentamidine isethionate as treatment and secondary prophylaxis for disseminated cutaneous leishmaniasis during HIV infection: case reportL Calza
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
J Chemother 13:653-7. 2001....
Laser acupuncture for acute inflammatory, visceral and neuropathic pain relief: An experimental study in the laboratory ratL Lorenzini
DIMORFIPA, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia Bologna, Italy
Res Vet Sci 88:159-65. 2010..g. cystitis due to cyclophosphamide. We thus provide evidences that acupoints stimulation using a very low intensity laser irradiation can control pain and edema in specific experimental conditions...
Use of fibrates in the management of hyperlipidemia in HIV-infected patients receiving HAARTL Calza
Dept of Clinical and Experimental Medicine, University of Bologna, S. Orsola Hospital, Italy
Infection 30:26-31. 2002....
Diffuse skin spread of HIV-associated visceral leishmaniasis: cumbersome diagnostic and therapeutic issuesR Manfredi
Division of Infectious Diseases, Department of Internal Medicine, Aging and Nephrologic Diseases, S Orsola Malpighi Hospital, Bologna, Italy
G Ital Dermatol Venereol 143:339-46. 2008..v. pentamidine isethionate together with oral paromomycin led to a slow, but complete cure of both visceral leishmaniasis and its related skin dissemination, in absence of adverse events and long-term disease relapses...
Frequency, epidemiology, risk factors, clinical and bacteriological features of enterococcal disease in patients with HIV infection in a decade surveyR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, Ospedale Policlinico S. Orsola-Malpighi
New Microbiol 25:179-86. 2002..1% of lethal cases among our septic patients)...
American cutaneous leishmaniasis as a rare imported disease in Europe: a case report favourably treated with antimonial derivativesR Manfredi
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Malpighi General Hospital, Italy
Eur J Epidemiol 17:793-5. 2001....
Human herpesvirus-8-related Kaposi's sarcoma after liver transplantation successfully treated with cidofovir and liposomal daunorubicinG Verucchi
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, S. Orsola Hospital Alma Mater Studiorum University of Bologna, Italy
Transpl Infect Dis 7:34-7. 2005....
Doxycycline and chloroquine as treatment for chronic Q fever endocarditisL Calza
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Bologna, Italy
J Infect 45:127-9. 2002..A case of chronic Q fever endocarditis is described in a patient with biological prosthetic aortic valve and aortic homograft, successfully treated with doxycycline and chloroquine for 2 years...
Role of c-Fos protein on glutamate toxicity in primary neural hippocampal cellsM Fernandez
Department of Veterinary Morphophysiology and Animal Production DIMORFIPA, University of Bologna, Bologna, Italy
J Neurosci Res 82:115-25. 2005..These results suggest that the synthesis of c-Fos protein after glutamate exposure favors cell death pathway activation in which caspase-3 is also involved...
Nevirapine versus efavirenz in 742 patients: no link of liver toxicity with female sex, and a baseline CD4 cell count greater than 250 cells/microlRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy
AIDS 20:2233-6. 2006....
Statins and fibrates for the treatment of hyperlipidaemia in HIV-infected patients receiving HAARTLeonardo Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna, S. Orsola Hospital, Italy
AIDS 17:851-9. 2003..CONCLUSIONS: All administered statins and fibrates revealed a similar, significant efficacy in the treatment of diet-resistant hyperlipidaemia, and showed a favourable tolerability profile...
Age-dependent impairment of hippocampal neurogenesis in chronic cerebral hypoperfusionS Sivilia
Animal Stem Cell Laboratory, DIMORFIPA, University of Bologna, Bologna, Italy
Neuropathol Appl Neurobiol 34:52-61. 2008....
Thyroid hormone induces glial lineage of primary neurospheres derived from non-pathological and pathological rat brain: implications for remyelination-enhancing therapiesM Fernandez
BioPharmaNet TransLab DIMORFIPA, University of Bologna, Ozzano Emilia, Italy
Int J Dev Neurosci 27:769-78. 2009....
[Economic burden and clinical course of HIV infection and AIDS today: how the variation of natural history, available treatments, and strictly related costs play a role in needs of health care]R Manfredi
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Università Alma Mater, Azienda Ospedaliera Policlinico S Orsola Malpighi, Bologna
Recenti Prog Med 92:648-54. 2001....
A case-control study of HIV-associated pancreatic abnormalities during HAART era. Focus on emerging risk factors and specific managementRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
Eur J Med Res 9:537-44. 2004..The epidemiological and clinical features of HIV-associated pancreatic abnormalities are expected to change after HAART introduction...
Spontaneous clearance of chronic hepatitis C infection in a patient with a 20-year-old HIV-hepatitis C co-infection and chronic active hepatitisR Manfredi
Department of Internal Medicine, Aging, and Nephrologic Diseases, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Via Massarenti 11, Bologna I 40138, Italy
Int J STD AIDS 23:e48-50. 2012....
Isolation of rat embryonic stem-like cells: a tool for stem cell research and drug discoveryM Fernandez
Health Science and Technology Interdepartmental Center for Industrial Research, University of Bologna, Ozzano Emilia, Bologna, Italy
Dev Dyn 240:2482-94. 2011..Collectively, the B1-RESC line with a stable near-diploid karyotype can be used as a highly sensitive tool for testing anti-proliferative molecules...
Iliac osteomyelitis and gluteal muscle abscess caused by Streptococcus intermediusL Calza
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
J Med Microbiol 50:480-2. 2001....
Osteonecrosis and highly active antiretroviral therapy during HIV infection: report of a series and literature reviewL Calza
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Bologna, Italy
AIDS Patient Care STDS 15:385-9. 2001..Five cases of osteonecrosis were observed among over 1300 patients with HIV disease. According to our experience, novel antiretroviral regimens do not represent a constant risk factor for avascular necrosis of bone during HIV infection...
Merkel cell carcinoma in a human immunodeficiency virus-infected patientL Calza
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Via Massarenti 11, 40138 Bologna, Italy
Br J Dermatol 146:895-8. 2002..A case of this cutaneous malignancy, characterized by a short-term local recurrence and systemic fatal spread in spite of surgical treatment, radiotherapy and chemotherapy, is described in a patient with advanced HIV infection...
Isolated generalised anhidrosis induced by postganglionic sympathetic skin nerve fibre degeneration: an incomplete Ross syndrome?V Donadio
Department of Neurological Sciences, University of Bologna, Italy
J Neurol Neurosurg Psychiatry 79:959-61. 2008..Isolated GA induced by degeneration of postganglionic sympathetic nerve fibers, directly evaluated by skin biopsy, has not previously been described...
Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factorsL Calza
Department of Veterinary Morphophysiology and Animal Production, University of Bologna, 40064 Ozzano Emilia, Bologna, Italy
Proc Natl Acad Sci U S A 98:4160-5. 2001....
Primary cytomegalovirus infection in otherwise healthy adults with Fever of unknown origin: a 3-year prospective surveyR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Via Massarenti 11, 40138 Bologna, Italy
Infection 34:87-90. 2006..Primary cytomegalovirus disease is probably still underestimated or missed in common clinical practice, and further prevalence studies should be performed, in particular in the setting of fever of under-determined origin (FUO) in adults...
Community-acquired Pseudomonas aeruginosa sacro-iliitis in a previously healthy patientL Calza
Department of Clinical and Experimental Medicine, University of Bologna, S Orsola Hospital, Italy
J Med Microbiol 51:620-2. 2002..The first case of Pseudomonas aeruginosa sacro-iliitis is described, which occurred in a previously healthy young man, without history of prior traumatic events, hospitalisation or chronic underlying disease...
p75(NTR)-immunoreactivity in the subventricular zone of adult male rats: expression by cycling cellsA Giuliani
DIMORFIPA, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell Emilia, Italy
J Mol Histol 35:749-58. 2004..p75(NTR)-IR was not increased in the early post-natal phase. Thus, p75(NTR) seems to be associated with cell cycle regulation in SVZ in adult rat brain...
Limited access to hospitalization in an Italian infectious disease wardR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
Med Mal Infect 34:144-7. 2004....
Thyroid hormone participates in the regulation of neural stem cells and oligodendrocyte precursor cells in the central nervous system of adult ratM Fernandez
Department of Veterinary Morphophysiology and Animal Production DIMORFIPA, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell Emilia, Italy
Eur J Neurosci 20:2059-70. 2004..These results indicate that thyroid hormone affects NSC and OPC proliferation and maturation also in adulthood...
Expression of peptides and other neurochemical markers in hypothalamus and olfactory bulb of mice devoid of all known thyroid hormone receptorsL Calza
Department of Veterinary Morphophysiology and Animal Production DIMORFIPA, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, Bologna, Italy
Neuroscience 101:1001-12. 2000..Together these studies reveal many regional and neurochemically selective alterations in neuronal phenotype of mice devoid of all known thyroid hormone receptors...
In vivo regulation of precursor cells in the subventricular zone of adult rat brain by thyroid hormone and retinoidsL Giardino
Department of Veterinary Morphophysiology and Animal Production DIMORFIPA, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell Emilia, Italy
Neurosci Lett 295:17-20. 2000..These data suggest that nuclear receptor ligands are potential candidates for fate determination of precursor cells in the subventricular zone also in the adult brain...
[Epidemics of bovine spongiform encephalopathy and new variant of Creutzfeldt-Jakob disease in humans. Most recent findings on prion disease]L Calza
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Sezione di Malattie Infettive, Universita degli Studi di Bologna, Policlinico S Orsola, Bologna
Recenti Prog Med 92:140-9. 2001..New epidemiological, clinical, histopathological and experimental data on prion diseases are reviewed, focusing our attention on the possible transmission of prion proteins from animals to humans...
A new syndrome of long-term idiopathic, severe CD4+ lymphocytopenia: isolated paraparesis and conjunctival ischemic microangiopathyR Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
J Biol Regul Homeost Agents 18:33-7. 2004....
Recent availability of two novel, fixed formulations of antiretroviral nucleoside analogues: a 12-month prospective, open-label survey of their practical use and therapeutic perspectives in antiretroviral-naive and -experienced patientsRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
AIDS Patient Care STDS 22:279-90. 2008....
Prolonged statin administration does not act on the cell-mediated immunity of HIV-infected dyslipidemic patients treated with a steady and effective highly active antiretroviral therapy. A two-year prospective study of statin versus fibrate administrationRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
J Biol Regul Homeost Agents 20:1-9. 2006....
Severe brain co-infection with Cryptococcus neoformans and Mycobacterium tuberculosis in a young, otherwise healthy student recently immigrated from ChinaRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Via Massarenti 11, I 40138 Bologna, Italy
Int J Infect Dis 12:438-41. 2008..Dual infective pathology in patients with cryptococcal meningitis. Neurology 1998;51:1213-5.]...
Efficacy and safety of atazanavir-ritonavir plus abacavir-lamivudine or tenofovir-emtricitabine in patients with hyperlipidaemia switched from a stable protease inhibitor-based regimen including one thymidine analogueLeonardo Calza
Department of Internal Medicine, Geriatrics and Nephrologic Diseases, Section of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, via G Massarenti 11, Bologna, Italy
AIDS Patient Care STDS 23:691-7. 2009....
[HIV infection: emerging issues and new challenges]Leonardo Calza
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Policlinico S Orsola, Alma Mater Studiorum Università, Bologna
Recenti Prog Med 97:771-80. 2006..Despite 20 years of effort, it is still a long way off, even also considerable progress has been made in understanding this problem...
A life-long antiretroviral treatment of congenital HIV disease, associated with a mixed fat redistribution syndrome and osteopenia already occurred during pre-pubertal ageRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Bologna, Italy
Int J STD AIDS 13:504-7. 2002....
Bladder carcinoma and HIV infection during the highly active antiretroviral therapy era: A rare, but intriguing association. Two case reports and literature reviewRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
Scand J Infect Dis 38:566-70. 2006..No relationship was found with the very favourable underlying HIV-related virological and immunological status, and the present 8-12-month follow-up did not show disease relapses...
[Two novel fixed formulations of nucleoside analogues (tenofovir-emtricitabine, and abacavir-lamivudine). Prospective, open study on clinical practice and therapeutic perspectives, in patients naïve and in subjects pre-treated with antiretrovirals]Roberto Manfredi
Dipartimento di Medicina Interna, dell Invecchiamento e delle Malattie Nefrologiche, Divisione di Malattie Infettive, Alma Mater Studiorum Universita di Bologna, Policlinico S Orsola Malpighi, Bologna
Recenti Prog Med 99:492-501. 2008....
Recurring Candida albicans esophagitis in a HIV-infected patient undergoing long-Term antiretroviral therapy, and with absent-negligible immunodeficiencyRoberto Manfredi
Division of Infectious Diseases, Department of Clinical and Experimental Medicine, S Orsola Malpighi Hospital, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Braz J Infect Dis 11:605-9. 2007....
HIV infection and the pancreas: risk factors and potential management guidelinesRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Int J STD AIDS 19:99-105. 2008..single (gabexate mesilate or ocreotide) therapy. Reduced disease recurrences and a better tolerability of antiretroviral regimens, were also noticed...
[Malignancies not included among AIDS-defining disorders, in the era of highly active antiretroviral therapy]Roberto Manfredi
Dipartimento di Medicina Interna, dell Invecchiamento e delle Malattie Nefrologiche, Divisione di Malattie Infettive, Policlinico S Orsola Malpighi, Alma Mater Studiorum Università, Bologna
Recenti Prog Med 100:547-9. 2009..The diagnostic and clinical implications are discussed on the ground of the most recent literature evidences...
[Systemic lupus erythematosus and HIV infection. A case report and review of the literature]Leonardo Calza
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Università Alma Mater, Policlinico S Orsola, Bologna
Recenti Prog Med 93:28-31. 2002..A HIV-infected female patient with systemic lupus erythematosus, occurred few months after the highly active anti-retroviral therapy initiation, is described...
Epidemiology and microbiology of cellulitis and bacterial soft tissue infection during HIV disease: a 10-year surveyRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Bologna, Italy
J Cutan Pathol 29:168-72. 2002..Cellulitis and soft tissue infection are underestimated complications of HIV disease...
Multiple opportunistic AIDS-associated disorders strictly related to immunodeficiency levels, in a girl with congenital HIV infectionRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, Alma Mater Studiorum, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
Int J STD AIDS 14:638-9. 2003....
Rosuvastatin, pravastatin, and atorvastatin for the treatment of hypercholesterolaemia in HIV-infected patients receiving protease inhibitorsLeonardo Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Hospital, Bologna, Italy
Curr HIV Res 6:572-8. 2008..All used statins showed a significant efficacy and a good tolerability in the treatment of diet-resistant hyperlipidaemia, but rosuvastatin was found to be more effective in reducing total and LDL cholesterol levels...
Increasing pathomorphism of pulmonary tuberculosis: an observational study of slow clinical, microbiological and imaging response of lung tuberculosis to specific treatment. Which role for linezolid?Roberto Manfredi
Department of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
Braz J Infect Dis 13:297-303. 2009..tuberculosis strains. Randomized clinical trials including initially patients with ascertained chemioresistant tuberculosis, are strongly warranted...
A prospective comparison of the two main indications of efavirenz in 2001 highly active antiretroviral therapy (HAART) regimens: first-line versus salvage useRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Via Massarenti 11, I 40138 Bologna, Italy
J Antimicrob Chemother 49:723-9. 2002..To determine the efficacy of efavirenz introduction in first-line HAART compared with salvage multidrug regimens...
Risk of premature atherosclerosis and ischemic heart disease associated with HIV infection and antiretroviral therapyLeonardo Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, Alma Mater Studiorum University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
J Infect 57:16-32. 2008....
Antiretroviral therapy voluntarily taken at half-dosage, but fully effective after 6-10 years: a provocative issue for adherence requirements: case reportRoberto Manfredi
Department of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Malpighi Hospital, Bologna, Italy
Curr HIV Res 6:171-2. 2008..The potential causes and consequences of this apparent misconduct of our patients on drug tolerability, resistance development, compliance monitoring, direct drug delivery, and health care providers behavior, are discussed...
[Screening of adult patients with fever of unknown origin. A prospective study on the role of primary cytomegalovirus infection]Roberto Manfredi
Dipartimento di Medicina Clinica Specialistica e Sperimentale, Divisione di Malattie Infettive, Università di Bologna Alma Mater Studiorum, Azienda Ospedaliera Policlinico S Orsola Malpighi, Bologna
Recenti Prog Med 97:79-84. 2006..5%) were found to have a primary Cytomegalovirus infection...
Chron's disease, rare association with selective IgA immunodeficiency, and development of life-threatening bacterial infectionsRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
Scand J Infect Dis 36:523-4. 2004..This unexpected association of a chronic bowel inflammatory syndrome with prominent IgA abnormalities and severe bacterial infection deserves careful attention by physicians faced with young patients with Chron's disease...
Ampicillin, gentamicin and teicoplanin as antimicrobial therapy for recurrent Streptococcus agalactiae and Enterococcus faecalis endocarditis in an intravenous drug abuser with HIV infectionLeonardo Calza
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Bologna, Italy
Chemotherapy 49:206-8. 2003..v. drug addict during HIV infection is presented. Antimicrobial therapy with i.v. ampicillin, gentamicin and teicoplanin led to complete clinical and echocardiographical recovery...
[The role of a novel antiretroviral class (fusion inhibitors) in the treatment of advanced HIV infection. Preliminary experience with enfuvirtide]Roberto Manfredi
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Universita degli Studi di Bologna Alma Mater Studiorum, Azienda Ospedaliera di Bologna, Policlinico S Orsola Malpighi, Bologna
Recenti Prog Med 96:124-30. 2005..The management of the very frequent site injection reactions represents an adjunctive problem in the treatment of these multi-problematic patients...
Systemic and discoid lupus erythematosus in HIV-infected patients treated with highly active antiretroviral therapyLeonardo Calza
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Italy
Int J STD AIDS 14:356-9. 2003..To our knowledge, this is the second case of DLE and the twenty-seventh case of SLE reported to date in association with HIV infection...
Incidence of hyperlipidaemia in a cohort of 212 HIV-infected patients receiving a protease inhibitor-based antiretroviral therapyLeonardo Calza
Department of Clinical and Experimental Medicine, Section of Infectious Diseases, University of Bologna, S Orsola Hospital, via G Massarenti 11, I 40138 Bologna, Italy
Int J Antimicrob Agents 22:54-9. 2003....
Efavirenz versus nevirapine in current clinical practice: a prospective, open-label observational studyRoberto Manfredi
Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
J Acquir Immune Defic Syndr 35:492-502. 2004....
[Limitation of access to an infectious disease ward due to lack of compatible hospital room. A four-year survey, and relevant observations]Roberto Manfredi
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Università Alma Mater Studiorum, Ospedale Policlinico S Orsola, Bologna
Recenti Prog Med 95:463-6. 2004..This occurrence happened in nearly 25% of patients trasferred from our Hospital from the year 2000...
Severe pneumococcal meningitis heralding a deep hypogammaglobulinaemia related to common variable immunodeficiency, at the age of 27 yearsRoberto Manfredi
Department of Clinical and Experimental Medicine, University of Bologna Alma Mater Studiorum, S Orsola Hospital, Bologna, Italy
Scand J Infect Dis 36:756-8. 2004..Clinicians should maintain an elevated suspicion for congenital immunodeficiency, especially when observing adult patients with a negligible prior history...
