Paolo Calabresi

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. ncbi request reprint Striatal synaptic plasticity: implications for motor learning and Parkinson's disease
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata and Fondazione Santa Lucia, I R C C S, Roma, Italy
    Mov Disord 20:395-402. 2005
  2. ncbi request reprint Chronic cocaine prevents depotentiation at corticostriatal synapses
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Biol Psychiatry 60:436-43. 2006
  3. doi request reprint Neuronal networks and synaptic plasticity in Parkinson's disease: beyond motor deficits
    Paolo Calabresi
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Parkinsonism Relat Disord 13:S259-62. 2007
  4. ncbi request reprint ACh/dopamine crosstalk in motor control and reward: a crucial role for alpha 6-containing nicotinic receptors?
    Paolo Calabresi
    Clinica Neurologica, Universita degli Studi di Perugia, 06156 Perugia, Italy IRCCS, Fondazione Santa Lucia, 00143 Rome, Italy
    Neuron 60:4-7. 2008
  5. pmc A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation
    Alessandro Tozzi
    Clinica Neurologica, Universita di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    PLoS ONE 7:e38312. 2012
  6. pmc Medication-overuse headache: pathophysiological insights
    Letizia Maria Cupini
    Ospedale Sant Eugenio, Reparto di Neurologia, Unità Operativa Cefalee, Piazzale dell Umanesimo, Rome, Italy
    J Headache Pain 6:199-202. 2005
  7. pmc Cortical spreading depression as a target for anti-migraine agents
    Cinzia Costa
    Neurologic Clinic, Department of Public Health and Medical and Surgical Specialties, University of Perugia, Ospedale Santa Maria della Misericordia, Sant Andrea delle Fratte, 06132, Perugia, Italy
    J Headache Pain 14:62. 2013
  8. ncbi request reprint New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson's disease
    Paolo Calabresi
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Lancet Neurol 12:811-21. 2013
  9. doi request reprint New synaptic and molecular targets for neuroprotection in Parkinson's disease
    Paolo Calabresi
    Clinical Neurology, University of Perugia, Perugia, Italy
    Mov Disord 28:51-60. 2013
  10. pmc Neuroacanthocytosis associated with a defect of the 4.1R membrane protein
    Antonio Orlacchio
    Laboratorio di Neurogenetica, Centro Europeo di Ricerca sul Cervello Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia, Rome, Italy
    BMC Neurol 7:4. 2007

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Striatal synaptic plasticity: implications for motor learning and Parkinson's disease
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata and Fondazione Santa Lucia, I R C C S, Roma, Italy
    Mov Disord 20:395-402. 2005
    ..The potential relevance of these findings in the control of motor function and in the pathogenesis both of PD and L-dopa-induced motor complications will be discussed...
  2. ncbi request reprint Chronic cocaine prevents depotentiation at corticostriatal synapses
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Biol Psychiatry 60:436-43. 2006
    ..A pathology of habit forming systems might underlie these features of addiction...
  3. doi request reprint Neuronal networks and synaptic plasticity in Parkinson's disease: beyond motor deficits
    Paolo Calabresi
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Parkinsonism Relat Disord 13:S259-62. 2007
    ..Other non-motor symptoms involve not only the central dopaminergic system, but also in the noradrenergic, serotoninergic and cholinergic transmitter systems...
  4. ncbi request reprint ACh/dopamine crosstalk in motor control and reward: a crucial role for alpha 6-containing nicotinic receptors?
    Paolo Calabresi
    Clinica Neurologica, Universita degli Studi di Perugia, 06156 Perugia, Italy IRCCS, Fondazione Santa Lucia, 00143 Rome, Italy
    Neuron 60:4-7. 2008
    ..find that alpha6-containing nicotinic acetylcholine receptors might selectively activate mesolimbic and mesostriatal dopaminergic neurons, enhancing striatal dopamine release and its behavioral consequences...
  5. pmc A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation
    Alessandro Tozzi
    Clinica Neurologica, Universita di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    PLoS ONE 7:e38312. 2012
    ..In this study, we analyzed the electrophysiological effects of cocaine and A2A-Rs antagonists in striatal slices and the motor effects produced by this pharmacological modulation in rodents...
  6. pmc Medication-overuse headache: pathophysiological insights
    Letizia Maria Cupini
    Ospedale Sant Eugenio, Reparto di Neurologia, Unità Operativa Cefalee, Piazzale dell Umanesimo, Rome, Italy
    J Headache Pain 6:199-202. 2005
    ..In this article, we analyse also the possible mechanisms that underlie sensitisation in MOH by comparing these mechanisms with those reported for other forms of drug addiction...
  7. pmc Cortical spreading depression as a target for anti-migraine agents
    Cinzia Costa
    Neurologic Clinic, Department of Public Health and Medical and Surgical Specialties, University of Perugia, Ospedale Santa Maria della Misericordia, Sant Andrea delle Fratte, 06132, Perugia, Italy
    J Headache Pain 14:62. 2013
    ..CSD models are useful tools for testing current and novel prophylactic drugs, providing knowledge on mechanisms of action relevant for migraine...
  8. ncbi request reprint New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson's disease
    Paolo Calabresi
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Lancet Neurol 12:811-21. 2013
    ..Furthermore, neurotrophic factors might interact with the hippocampal dopaminergic system having possible implications on the non-motor symptoms seen in patients with Parkinson's disease. ..
  9. doi request reprint New synaptic and molecular targets for neuroprotection in Parkinson's disease
    Paolo Calabresi
    Clinical Neurology, University of Perugia, Perugia, Italy
    Mov Disord 28:51-60. 2013
    ....
  10. pmc Neuroacanthocytosis associated with a defect of the 4.1R membrane protein
    Antonio Orlacchio
    Laboratorio di Neurogenetica, Centro Europeo di Ricerca sul Cervello Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia, Rome, Italy
    BMC Neurol 7:4. 2007
    ..We report clinical, biochemical, and genetic features in four patients from four unrelated families with NA in order to explain the cause of morphological abnormalities and the relationship with neurodegenerative processes...
  11. ncbi request reprint Dopamine-mediated regulation of corticostriatal synaptic plasticity
    Paolo Calabresi
    Clinica Neurologica, Universita di Perugia, Ospedale S Maria della Misericordia, Via S Andrea delle Fratte, 06156, Perugia, Italy
    Trends Neurosci 30:211-9. 2007
    ..Finally, we discuss how endogenous dopamine crucially influences changes in synaptic plasticity induced by pathological stimuli, such as energy deprivation...
  12. ncbi request reprint Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap
    Paolo Calabresi
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy
    Lancet Neurol 9:1106-17. 2010
    ....
  13. ncbi request reprint Antiepileptic drugs in migraine: from clinical aspects to cellular mechanisms
    Paolo Calabresi
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia 06156, Italy
    Trends Pharmacol Sci 28:188-95. 2007
    ..Cortical spreading depression has been found to be involved in the pathophysiology of epilepsy, in addition to the generation of migraine aura...
  14. doi request reprint Molecular mechanisms underlying levodopa-induced dyskinesia
    Paolo Calabresi
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Mov Disord 23:S570-9. 2008
    ....
  15. ncbi request reprint A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine-acetylcholine synaptic balance
    Paolo Calabresi
    Clinica Neurologica, Dip Specialità Medico Chirurgiche, Universita di Perugia, Italy
    Lancet Neurol 5:974-83. 2006
    ..We also discuss a convergent versus parallel model to explain cognitive dysfunctions in Parkinson's disease according to dopamine-acetylcholine dependent alterations in synaptic plasticity...
  16. ncbi request reprint Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition
    Cinzia Costa
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, 06156 Perugia, Italy
    J Neurosci 28:8040-52. 2008
    ..Differential targeting of GABAergic transmission may represent a possible therapeutic strategy against basal ganglia neurodegenerative disorders involving mitochondrial complex I dysfunction...
  17. doi request reprint Hippocampal synaptic plasticity, memory, and epilepsy: effects of long-term valproic acid treatment
    Carmelo Sgobio
    Fondazione Santa Lucia, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Biol Psychiatry 67:567-74. 2010
    ....
  18. ncbi request reprint Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, 00133 Rome, Italy
    J Neurosci 23:8506-12. 2003
    ....
  19. ncbi request reprint Electrophysiological actions of zonisamide on striatal neurons: Selective neuroprotection against complex I mitochondrial dysfunction
    Cinzia Costa
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Exp Neurol 221:217-24. 2010
    ....
  20. ncbi request reprint Abnormal striatal GABA transmission in the mouse model for the fragile X syndrome
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Biol Psychiatry 63:963-73. 2008
    ..Structural and functional neuroimaging studies suggest abnormal activity in the striatum of patients with the fragile X syndrome (FXS), the most common form of inherited mental retardation...
  21. doi request reprint Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson's disease
    Cinzia Costa
    Clinica Neurologica, Universita di Perugia, Ospedale S Maria della Misericordia, S Andrea delle Fratte, 06156 Perugia, Italy
    Brain 135:1884-99. 2012
    ....
  22. ncbi request reprint Plastic and behavioral abnormalities in experimental Huntington's disease: a crucial role for cholinergic interneurons
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 65, 00143 Rome, Italy
    Neurobiol Dis 22:143-52. 2006
    ....
  23. ncbi request reprint Chronic haloperidol promotes corticostriatal long-term potentiation by targeting dopamine D2L receptors
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, 00133 Rome, Italy
    J Neurosci 24:8214-22. 2004
    ..The identification of the cellular, molecular, and receptor mechanisms involved in the action of haloperidol in the brain is essential to understand how antipsychotic agents exert their beneficial and side effects...
  24. ncbi request reprint Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission
    Alessandro Tozzi
    Clinica Neurologia, Universita di Perugia, Ospedale S Maria della Misericordia, 06156 Perugia, Italy
    Neuropharmacology 53:783-9. 2007
    ..These results suggest that A2A and D2 receptors converge in the control of corticostriatal glutamatergic transmission by exerting an opposite function...
  25. ncbi request reprint Inhibition of mitochondrial complex II alters striatal expression of genes involved in glutamatergic and dopaminergic signaling: possible implications for Huntington's disease
    Maddalena Napolitano
    Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Rome, Italy
    Neurobiol Dis 15:407-14. 2004
    ..Our data provide new information about the molecular events possibly underlying neurodegeneration induced by this mitochondrial toxin...
  26. ncbi request reprint Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, 00133 Rome, Italy
    J Neurosci 23:6245-54. 2003
    ....
  27. doi request reprint Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition
    Vincent Paille
    Fondazione Santa Lucia, Instituto di Ricovero e Cura a Carattere Scientifico, 00179 Rome, Italy
    J Neurosci 30:14182-93. 2010
    ..The use of the TAT2A cell-permeable peptide, as an innovative therapeutic strategy in early PD, rescues physiological NMDA receptor composition, synaptic plasticity, and motor behavior...
  28. ncbi request reprint NR2B-containing NMDA receptors promote the neurotoxic effects of 3-nitropropionic acid but not of rotenone in the striatum
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, 00133 Rome, Italy
    Exp Neurol 202:470-9. 2006
    ....
  29. ncbi request reprint Endogenous dopamine amplifies ischemic long-term potentiation via D1 receptors
    Emilia Saulle
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, and IRCCS Fondazione Santa Lucia, Rome, Italy
    Stroke 33:2978-84. 2002
    ..In an attempt to clarify how dopamine takes part in ischemia-induced neuronal damage, we performed in vitro electrophysiological recordings from neurons of the nucleus striatum...
  30. ncbi request reprint Deficits of glutamate transmission in the striatum of toxic and genetic models of Huntington's disease
    Silvia Rossi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neurosci Lett 410:6-10. 2006
    ..In both models, we found a significant down-regulation of glutamate transmission, suggesting that reduced synaptic excitation of the input structure of the basal ganglia represents a physiological correlate of HD...
  31. doi request reprint mTOR inhibitor rapamycin suppresses striatal post-ischemic LTP
    Veronica Ghiglieri
    Fondazione Santa Lucia IRCCS, Via del Fosso di Fiorano, 64, 00143, Rome, Italy
    Exp Neurol 226:328-31. 2010
    ..The present results argue for a role of mTOR complex in i-LTP and suggest that rapamycin, by selectively blocking i-LTP, represents a promising therapeutic tool to limit cellular damage after ischemic brain insult...
  32. doi request reprint Dopamine-dependent long-term depression is expressed in striatal spiny neurons of both direct and indirect pathways: implications for Parkinson's disease
    Vincenza Bagetta
    Fondazione Santa Lucia, Instituto di Ricovero e Cura a Carattere Scientifico, 00143 Rome, Italy
    J Neurosci 31:12513-22. 2011
    ..Our findings suggest caution in the use of this tool and indicate that the "striatal segregation" hypothesis might not explain all synaptic dysfunctions in Parkinson's disease...
  33. pmc TrkB/BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: modulation by valproic acid
    Veronica Ghiglieri
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropsychopharmacology 35:1531-40. 2010
    ..Our results provide the first indication that BDNF is involved in determining the striatal alterations occurring in the early-onset epileptic syndrome associated with the absence of presynaptic protein Bassoon...
  34. ncbi request reprint Abnormal Ca2+-calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 24:5283-91. 2004
    ..Normalization of CaMKII activity may be an important underlying mechanism of the therapeutic action of L-DOPA in PD...
  35. ncbi request reprint l-DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS c o CERC, Rome, Italy
    Neurobiol Dis 29:327-35. 2008
    ....
  36. doi request reprint A2A adenosine receptor antagonists protect the striatum against rotenone-induced neurotoxicity
    Vincenzo Belcastro
    Clinica Neurologia, Universita di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Exp Neurol 217:231-4. 2009
    ..The use of A2A receptor antagonists might represent a promising neuroprotective strategy in basal ganglia disorders involving a deficit of mitochondrial complex I activity...
  37. doi request reprint Acetyl-L-Carnitine selectively prevents post-ischemic LTP via a possible action on mitochondrial energy metabolism
    Vincenza Bagetta
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS c o CERC, Via del Fosso di Fiorano 64, 00143 Rome, Italy
    Neuropharmacology 55:223-9. 2008
    ..Our data demonstrate that ALC exerts neuroprotective effects by preventing the expression of pathological synaptic plasticity induced by ischemia. These effects crucially depend on the ability on ALC to affect mitochondrial processes...
  38. doi request reprint Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia
    Barbara Picconi
    Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00143, Rome, Italy
    Brain 134:375-87. 2011
    ....
  39. doi request reprint The distinct role of medium spiny neurons and cholinergic interneurons in the D₂/A₂A receptor interaction in the striatum: implications for Parkinson's disease
    Alessandro Tozzi
    Clinica Neurologica, Universita di Perugia, Ospedale S Maria della Misericordia, 06156 Perugia, Italy
    J Neurosci 31:1850-62. 2011
    ....
  40. pmc Ischemic-LTP in striatal spiny neurons of both direct and indirect pathway requires the activation of D1-like receptors and NO/soluble guanylate cyclase/cGMP transmission
    Sara Arcangeli
    Clinica Neurologica, Universita di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    J Cereb Blood Flow Metab 33:278-86. 2013
    ..We propose that NO, produced by striatal NOS-positive interneurons via the stimulation of D1-like-R located on these cells, is critical for i-LTP induction in the entire population of MSNs involving a cGMP-dependent pathway...
  41. ncbi request reprint Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striatum of R6/2 Huntington's disease mice
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Italy
    Biol Psychiatry 57:1583-9. 2005
    ..How this alteration impacts striatal synaptic transmission is unknown...
  42. ncbi request reprint Therapeutic doses of L-dopa reverse hypersensitivity of corticostriatal D2-dopamine receptors and glutamatergic overactivity in experimental parkinsonism
    Barbara Picconi
    Dipartimento di Neuroscienze, Clinica Neurologica, Universita di Roma Tor Vergata, Rome, Italy
    Brain 127:1661-9. 2004
    ....
  43. doi request reprint Epilepsy-induced abnormal striatal plasticity in Bassoon mutant mice
    Veronica Ghiglieri
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS c o CERC, Rome, Italy
    Eur J Neurosci 29:1979-93. 2009
    ....
  44. ncbi request reprint Synaptic plasticity during recovery from permanent occlusion of the middle cerebral artery
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Neurobiol Dis 27:44-53. 2007
    ..Our results provide a synaptic correlate of the long-lasting brain hyperexcitability mediating recovery described with noninvasive neurophysiological approaches...
  45. ncbi request reprint NR2B subunit exerts a critical role in postischemic synaptic plasticity
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, Rome, Italy
    Stroke 37:1895-901. 2006
    ..We characterized the differential effect of the NR2B subunit antagonist ifenprodil in the induction of activity-dependent long-term potentiation (LTP) and of postischemic LTP as well as in the neuronal damage induced by focal ischemia...
  46. ncbi request reprint Short-term and long-term plasticity at corticostriatal synapses: implications for learning and memory
    Massimiliano Di Filippo
    Clinica Neurologica, Laboratori di Neurologia Sperimentale, Universita di Perugia, Perugia, Italy
    Behav Brain Res 199:108-18. 2009
    ....
  47. ncbi request reprint Coactivation of GABA(A) and GABA(B) receptor results in neuroprotection during in vitro ischemia
    Cinzia Costa
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Rome, Italy
    Stroke 35:596-600. 2004
    ....
  48. doi request reprint Performance of aβ1-40, aβ1-42, total tau, and phosphorylated tau as predictors of dementia in a cohort of patients with mild cognitive impairment
    Lucilla Parnetti
    Clinica Neurologica, Universita degli Studi di Perugia, Perugia, Italy
    J Alzheimers Dis 29:229-38. 2012
    ..The best model of logistic regression analysis retained Aβ1-42 and p-tau (sensitivity 75%, 95%CI: 70-80%; specificity 96%, 95%CI: 94-98%). We can conclude that Aβ1-42 and p-tau reliably predict conversion to AD in MCI patients...
  49. ncbi request reprint Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemia
    Cinzia Costa
    Clinica Neurologica, Universita di Perugia, Ospedale Silvestrini, S Andrea delle Fratte, Perugia, Italy
    Stroke 37:1319-26. 2006
    ..In particular, the aim of the study was to correlate the putative neuroprotective effects with the action of these drugs on fast sodium (Na+) and high-voltage-activated (HVA) calcium (Ca2+) currents...
  50. ncbi request reprint Pathological synaptic plasticity in the striatum: implications for Parkinson's disease
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata and Fondazione Santa Lucia, I R C C S, Via di Tor Vergata 135, Roma, Italy
    Neurotoxicology 26:779-83. 2005
    ..The potential relevance of these findings in the control of motor function and in the pathogenesis both of Parkinson's disease and l-dopa-induced motor complications will be discussed...
  51. ncbi request reprint Neuronal vulnerability following inhibition of mitochondrial complex II: a possible ionic mechanism for Huntington's disease
    Emilia Saulle
    Clinica Neurologica, Dipartimento di Medicina Clinica e Sperimentale, Universita di Ferrara, Ferrara, Italy
    Mol Cell Neurosci 25:9-20. 2004
    ..Conversely, the hyperpolarization did not significantly differ from the one recorded in WT mice. The diverse membrane changes induced by SD inhibition may contribute to the cell-type-specific neuronal death in HD...
  52. ncbi request reprint A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and IRCCS Fondazione Santa Lucia, Rome, Italy
    Neuropsychopharmacology 29:1488-97. 2004
    ..Understanding the molecular and physiological effects of drugs of abuse in the brain is essential for the development of effective strategies against addiction...
  53. doi request reprint Striatum-hippocampus balance: from physiological behavior to interneuronal pathology
    Veronica Ghiglieri
    Fondazione Santa Lucia IRCCS, Via del Fosso di Fiorano, Rome, Italy
    Prog Neurobiol 94:102-14. 2011
    ..As interneuronal dysfunction plays a primary role in the pathogenesis of these disorders, interneurons can be viewed as critical elements in neurophysiological substrates of such flexible relationships between these two memory systems...
  54. doi request reprint Rebalance of striatal NMDA/AMPA receptor ratio underlies the reduced emergence of dyskinesia during D2-like dopamine agonist treatment in experimental Parkinson's disease
    Vincenza Bagetta
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, Istituto di Ricovero e Cura a Carattere Scientifico, 00143 Rome, Italy
    J Neurosci 32:17921-31. 2012
    ....
  55. doi request reprint A critical role of NO/cGMP/PKG dependent pathway in hippocampal post-ischemic LTP: modulation by zonisamide
    Cinzia Costa
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Neurobiol Dis 44:185-91. 2011
    ..Moreover, these findings strongly suggest that NO/cGMP/PKG intracellular cascade might represent a physiological target for neuroprotection in pathological forms of synaptic plasticity such as hippocampal iLTP...
  56. doi request reprint Synaptic dysfunction in Parkinson's disease
    Vincenza Bagetta
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, I R C C S, 00143 Rome, Italy
    Biochem Soc Trans 38:493-7. 2010
    ..According to these pathophysiological concepts, therapeutic strategies targeting signalling proteins coupled to NMDARs within striatal spiny neurons could represent new pharmaceutical interventions for PD and L-dopa-induced dyskinesia...
  57. ncbi request reprint Dopamine, acetylcholine and nitric oxide systems interact to induce corticostriatal synaptic plasticity
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Rev Neurosci 14:207-16. 2003
    ....
  58. ncbi request reprint Inhibition of persistent sodium current fraction and voltage-gated L-type calcium current by propofol in cortical neurons: implications for its antiepileptic activity
    Giuseppina Martella
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Epilepsia 46:624-35. 2005
    ..We examined the electrophysiologic effects of propofol on an in vitro model of epileptic activity obtained from a slice preparation...
  59. ncbi request reprint Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Epilepsia 45:719-28. 2004
    ..Levetiracetam (LEV) and lamotrigine (LTG), novel antiepileptic drugs (AEDs), were tested on epileptiform events and the corresponding elevations in intracellular Ca2+ concentration ([Ca2+]i) recorded from rat neocortical slices...
  60. ncbi request reprint Behavioural learning-induced increase in spontaneous GABAA-dependent synaptic activity in rat striatal cholinergic interneurons
    Paola Bonsi
    Fondazione Santa Lucia IRCCS, Rome and Department of Neuroscience, Neurological Clinic, University Tor Vergata, Rome, Italy
    Eur J Neurosci 17:174-8. 2003
    ..This intrastriatal mechanism might be involved in the phasic suppression of discharge of TANs at the presentation of reward-related sensory stimuli...
  61. ncbi request reprint Tissue plasminogen activator is required for corticostriatal long-term potentiation
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur J Neurosci 16:713-21. 2002
    ....
  62. ncbi request reprint Mortalin inhibition in experimental Parkinson's disease
    Davide Chiasserini
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Mov Disord 26:1639-47. 2011
    ..These findings suggest a critical link between mortalin function and mitochondrial activity in both physiological and pathological conditions mimicking Parkinson's disease...
  63. ncbi request reprint The endocannabinoid system in Parkinson's disease
    Massimiliano Di Filippo
    Clinica Neurologica, Ospedale S Maria della Misericordia, Universita di Perugia, 06156 Perugia, Italy
    Curr Pharm Des 14:2337-47. 2008
    ....
  64. doi request reprint Effects of central and peripheral inflammation on hippocampal synaptic plasticity
    Massimiliano Di Filippo
    Clinica Neurologica, Universita di Perugia, Perugia, Italy
    Neurobiol Dis 52:229-36. 2013
    ..During direct CNS inflammation these events are accompanied by detectable changes in synaptic glutamate receptors subunit composition and in the levels of the pro-inflammatory cytokine IL1β...
  65. ncbi request reprint Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, I R C C S Fondazione Santa Lucia, Italy
    Brain 125:2635-45. 2002
    ..We suggest that an enhanced sensitivity of pre-synaptic inhibitory mGlu2/3 receptors might represent an adaptive change triggered by dopaminergic denervation, which can be reversed by L-DOPA treatment...
  66. pmc Critical role of calcitonin gene-related peptide receptors in cortical spreading depression
    Alessandro Tozzi
    Clinica Neurologica, Universita di Perugia, 06156 Perugia, Italy
    Proc Natl Acad Sci U S A 109:18985-90. 2012
    ..They also demonstrate that CGRP antagonism reduces CSD, supporting the possible use of drugs targeting central CGRP receptors as antimigraine agents...
  67. ncbi request reprint Metabotropic glutamate 2 receptors modulate synaptic inputs and calcium signals in striatal cholinergic interneurons
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 22:6176-85. 2002
    ..These results suggest that the mGlu2 receptor-mediated modulatory action on cell excitability would tune striatal ACh release, representing an interesting target for pharmacological intervention in basal ganglia disorders...
  68. ncbi request reprint The brain cytoplasmic RNA BC1 regulates dopamine D2 receptor-mediated transmission in the striatum
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    J Neurosci 27:8885-92. 2007
    ....
  69. doi request reprint Impaired plasticity at specific subset of striatal synapses in the Ts65Dn mouse model of Down syndrome
    Massimiliano Di Filippo
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Via S Andrea delle Fratte, 06156 Perugia, Italy
    Biol Psychiatry 67:666-71. 2010
    ....
  70. doi request reprint Striatal synaptic changes in experimental parkinsonism: role of NMDA receptor trafficking in PSD
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS c o CERC, Via del Fosso di Fiorano 64, Rome, Italy
    Parkinsonism Relat Disord 14:S145-9. 2008
    ....
  71. ncbi request reprint Dopamine excites fast-spiking interneurons in the striatum
    Enrico Bracci
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome 00133, Italy
    J Neurophysiol 87:2190-4. 2002
    ..These results show that endogenous dopamine exerts a dual excitatory action on FS interneurons, by directly depolarizing them (through D1-like receptors) and by reducing their synaptic inhibition (through presynaptic D2-like receptors)...
  72. doi request reprint Levetiracetam in newly diagnosed late-onset post-stroke seizures: a prospective observational study
    Vincenzo Belcastro
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Epilepsy Res 82:223-6. 2008
    ..These observations suggest that LEV exhibits safety and efficacy profiles which make it an optimal candidate as a first-choice drug against post-stroke seizures...
  73. ncbi request reprint Post-ischaemic long-term synaptic potentiation in the striatum: a putative mechanism for cell type-specific vulnerability
    Paolo Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata and IRCCS Fondazione Santa Lucia, Rome, Italy
    Brain 125:844-60. 2002
    ..We suggest that i-LTP represents a pathological form of synaptic plasticity that may account for the cell type-specific vulnerability observed in striatal spiny neurones following ischaemia and energy deprivation...
  74. ncbi request reprint Activation of dopamine D1-like receptors excites LTS interneurons of the striatum
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via di Tor Vergata, 135, 00133 Rome, Italy
    Eur J Neurosci 15:2049-52. 2002
    ..In addition, this pharmacological effect was mimicked by D1- but not D2-like DA receptor agonists, implying the selective involvement of D1-like receptors in this action...
  75. ncbi request reprint Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Nat Neurosci 6:501-6. 2003
    ..These results indicate that abnormal information storage in corticostriatal synapses is linked with the development of L-DOPA-induced dyskinesia...
  76. ncbi request reprint Acetyl-L-carnitine protects striatal neurons against in vitro ischemia: the role of endogenous acetylcholine
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropharmacology 50:917-23. 2006
    ..These findings show that ALC exert a neuroprotective action against in vitro ischemia. This neuroprotective effect requires the activity of choline uptake system and the activation of M2 muscarinic receptors...
  77. doi request reprint Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias
    Lucilla Parnetti
    Clinica Neurologica, Universita di Perugia, Perugia, Italy
    Mov Disord 26:1428-35. 2011
    ..In particular, total tau/α-synuclein and phosphorylated tau/α-synuclein ratios can contribute to the discrimination of Parkinson's disease. © 2011 Movement Disorder Society...
  78. ncbi request reprint Pathways of neurodegeneration and experimental models of basal ganglia disorders: downstream effects of mitochondrial inhibition
    Massimiliano Di Filippo
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale Silvestrini, Perugia, Italy
    Eur J Pharmacol 545:65-72. 2006
    ..The downstream effects triggered by mitochondrial complexes inhibition provide a model integrating genetic and environmental pathogenic factors to explain the selective neuronal vulnerability...
  79. ncbi request reprint Increased levels of neurotrophins are not specific for chronic migraine: evidence from primary fibromyalgia syndrome
    Paola Sarchielli
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia, Italy
    J Pain 8:737-45. 2007
    ..NGF might indirectly exert its effect through enhancing glutamatergic transmission via BDNF. The above mechanisms could account for sustained central sensitization in both chronic pain states...
  80. ncbi request reprint Dopamine D2 receptor-mediated inhibition of dopaminergic neurons in mice lacking D2L receptors
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropsychopharmacology 27:723-6. 2002
    ..Thus, pharmacological compounds able to interfere selectively with presynaptic D2S receptors might constitute effective therapeutic strategies in neuropsychiatric disorders, by causing negligible side-effects...
  81. doi request reprint CSF levels of heart fatty acid binding protein are altered during early phases of Alzheimer's disease
    Davide Chiasserini
    Clinica Neurologica, Ospedale S Maria della Misericordia, Universita di Perugia, Perugia, Italy
    J Alzheimers Dis 22:1281-8. 2010
    ..7). A significant correlation between HFABP/Aβ1-42 ratio and MMSE annual decrease rate was also documented (p<0.0001). HFABP /Aβ1-42 ratio might be a useful predictor of conversion in MCI patients...
  82. ncbi request reprint Cerebrospinal fluid biomarkers in Parkinson's disease with dementia and dementia with Lewy bodies
    Lucilla Parnetti
    Section of Neurology, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia General Hospital, Perugia, Italy
    Biol Psychiatry 64:850-5. 2008
    ..Thus, analysis of cerebrospinal fluid (CSF) biomarkers (beta-amyloid(1-42) [Abeta42], total tau, and hyperphosphorylated tau [p-tau]) in living subjects might provide significant pathophysiological information on these diseases...
  83. ncbi request reprint Practical considerations for the treatment of elderly patients with migraine
    Paola Sarchielli
    Department of Medical and Surgical Specialties and Public Health, Neurologic Clinic, University of Perugia, Perugia, Italy
    Drugs Aging 23:461-89. 2006
    ..Unfortunately, for most of these drugs, efficacy studies are lacking in the elderly...
  84. pmc Application of ICHD 2nd edition criteria for primary headaches with the aid of a computerised, structured medical record for the specialist
    Paola Sarchielli
    Neurologic Clinic, Dept of Medical and Surgical Specialties and Public Health, University of Perugia, Silvestrini Hospital, S Andrea delle Fratte, I 06156 Perugia, Italy
    J Headache Pain 6:205-10. 2005
    ..This computerised device may help to validate the new diagnostic criteria and to answer some emerging questions from the application of the new classification version, the relevance of which should be verified in clinical practice...
  85. ncbi request reprint Cocaine and amphetamine depress striatal GABAergic synaptic transmission through D2 dopamine receptors
    Diego Centonze
    Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata and Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropsychopharmacology 26:164-75. 2002
    ..The modulation of GABAergic synaptic transmission in the striatum might underlie some motor and cognitive effects of psychostimulants in mammalians...
  86. ncbi request reprint Tissue plasminogen activator is required for striatal post-ischemic synaptic potentiation
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Neuroreport 13:115-8. 2002
    ..The absence of striatal post-ischemic pote ntiat ion observed in tPA-lacking mice may account for the significant neuroprotection observed in these animals after the occlusion of middle cerebral artery...
  87. ncbi request reprint Synaptic plasticity in the ischaemic brain
    Paolo Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and the IRCCS Fondazione Santa Lucia, Rome, Italy
    Lancet Neurol 2:622-9. 2003
    ..We discuss evidence that ischaemia could also induce protective and reparative forms of neuronal plasticity that may play a part in ischaemic tolerance and poststroke recovery...
  88. ncbi request reprint Plastic abnormalities in experimental Huntington's disease
    Massimiliano Di Filippo
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Via S Andrea delle Fratte, 06156, Perugia, Italy IRCCS Fondazione Santa Lucia, Rome, Italy
    Curr Opin Pharmacol 7:106-11. 2007
    ..As long-term potentiation and long-term depression represent the accepted model for neuronal learning processes, their impairment could account for the onset and progression of both motor and cognitive symptoms of HD...
  89. ncbi request reprint Cyclic vomiting syndrome, migraine, and epilepsy: a common underlying disorder?
    Letizia M Cupini
    Clinica Neurologica, Ospedale S Eugenio, Universita di Roma Tor Vergata, Piazza le Umanesimo 10, 00144 Rome, Italy
    Headache 43:407-9. 2003
  90. ncbi request reprint Removing pathogenic memories: a neurobiology of psychotherapy
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Mol Neurobiol 32:123-32. 2005
    ....
  91. ncbi request reprint Metabotropic glutamate receptors and striatal synaptic plasticity: implications for neurological diseases
    Paolo Gubellini
    Interactions Cellulaires, Neurodégénérescence et Neuroplasticité IC2N UMR6186, Centre National de la Recherche Scientifique CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Prog Neurobiol 74:271-300. 2004
    ....
  92. ncbi request reprint A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia
    Fabrizio Gardoni
    Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy
    J Neurosci 26:2914-22. 2006
    ..These data indicate abnormal NR2B redistribution between synaptic and extrasynaptic membranes as an important molecular disturbance of the glutamatergic synapse involved in L-DOPA-induced dyskinesia...
  93. ncbi request reprint Ionotropic glutamate receptors: still a target for neuroprotection in brain ischemia? Insights from in vitro studies
    Paolo Calabresi
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neurobiol Dis 12:82-8. 2003
    ..In addition, our findings support the concept that it is possible to produce a significant neuroprotective action in the absence of a relevant interference with normal synaptic transmission...
  94. ncbi request reprint Stimulus frequency, calcium levels and striatal synaptic plasticity
    Paola Bonsi
    Fondazione Santa Lucia, IRCCS Rome
    Neuroreport 14:419-22. 2003
    ..These results suggest that the induction of long-term depression required large, transient increases in intracellular calcium concentration...
  95. pmc Voltage-dependent membrane potential oscillations of rat striatal fast-spiking interneurons
    Enrico Bracci
    Department of Optometry and Neuroscience, UMIST, Manchester M60 1QD, UK
    J Physiol 549:121-30. 2003
    ....
  96. ncbi request reprint Antiepileptic drugs as a possible neuroprotective strategy in brain ischemia
    Paolo Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Ann Neurol 53:693-702. 2003
    ....
  97. ncbi request reprint Experimental parkinsonism modulates multiple genes involved in the transduction of dopaminergic signals in the striatum
    Maddalena Napolitano
    Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Rome, Italy
    Neurobiol Dis 10:387-95. 2002
    ....
  98. ncbi request reprint Induction of corticostriatal LTP by 3-nitropropionic acid requires the activation of mGluR1/PKC pathway
    Paolo Gubellini
    Interactions Cellulaires, Neurodégénérescence et Neuroplasticité IC2N, CNRS, 13402 Marseille Cedex 20, France
    Neuropharmacology 46:761-9. 2004
    ..Characterizing the cellular mechanisms underlying 3-NP-LTP may provide new insights to better understand the processes leading to the selective neuronal loss observed in HD...
  99. ncbi request reprint Engagement of rat striatal neurons by cortical epileptiform activity investigated with paired recordings
    Enrico Bracci
    Department of Optometry and Neuroscience, University of Manchester Institute of Science Technology, Manchester M60 1QD, UK
    J Neurophysiol 92:2725-37. 2004
    ..Cholinergic interneurons located < 120 microm from simultaneously recorded MSs, did not display cortically driven bursts, suggesting that these cells are much less easily engaged by cortical epileptiform activity...
  100. pmc Coordinate high-frequency pattern of stimulation and calcium levels control the induction of LTP in striatal cholinergic interneurons
    Paola Bonsi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia I R C C S, 00179 Roma, Italy
    Learn Mem 11:755-60. 2004
    ..In conclusion, the expression of LTP in striatal cholinergic interneurons is a selective response to a precise stimulation pattern of induction requiring a critical rise in [Ca2+]i...
  101. ncbi request reprint Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
    Matthew S Goldberg
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 45:489-96. 2005
    ..Furthermore, DJ-1(-/-) mice displayed hypoactivity in the open field. Collectively, our findings suggest an essential role for DJ-1 in dopaminergic physiology and D2 receptor-mediated functions...