P Calabresi

Summary

Affiliation: University of Rome Tor Vergata
Country: Italy

Publications

  1. ncbi request reprint Post-ischaemic long-term synaptic potentiation in the striatum: a putative mechanism for cell type-specific vulnerability
    Paolo Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata and IRCCS Fondazione Santa Lucia, Rome, Italy
    Brain 125:844-60. 2002
  2. ncbi request reprint Is pharmacological neuroprotection dependent on reduced glutamate release?
    P Calabresi
    Clinica Neurologica, Dipartimiento Neuroscienze, Universita di Tor Vergata, Rome, Italy
    Stroke 31:766-72; discussion 773. 2000
  3. ncbi request reprint Electrophysiology of sipatrigine: a lamotrigine derivative exhibiting neuroprotective effects
    P Calabresi
    Clinica Neurologica, Universita Tor Vergata, Rome, 00133, Italy
    Exp Neurol 162:171-9. 2000
  4. ncbi request reprint Synaptic transmission in the striatum: from plasticity to neurodegeneration
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata 135, 00133, Rome, Italy
    Prog Neurobiol 61:231-65. 2000
  5. ncbi request reprint Ionotropic glutamate receptors: still a target for neuroprotection in brain ischemia? Insights from in vitro studies
    Paolo Calabresi
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neurobiol Dis 12:82-8. 2003
  6. ncbi request reprint Tissue plasminogen activator controls multiple forms of synaptic plasticity and memory
    P Calabresi
    Clinica Neurologica, Dip Neuroscienze, Universita di Tor Vergata, Via di Tor Vergata 135, Rome 00133, Italy
    Eur J Neurosci 12:1002-12. 2000
  7. ncbi request reprint Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Rome, Italy
    J Neurosci 20:8443-51. 2000
  8. ncbi request reprint Cellular factors controlling neuronal vulnerability in the brain: a lesson from the striatum
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, and the IRCCS, S Lucia, Rome, Italy
    Neurology 55:1249-55. 2000
  9. ncbi request reprint Activation of metabotropic glutamate receptor subtype 1/protein kinase C/mitogen-activated protein kinase pathway is required for postischemic long-term potentiation in the striatum
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Roma, Italy
    Mol Pharmacol 60:808-15. 2001
  10. ncbi request reprint Antiepileptic drugs as a possible neuroprotective strategy in brain ischemia
    Paolo Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Ann Neurol 53:693-702. 2003

Detail Information

Publications128 found, 100 shown here

  1. ncbi request reprint Post-ischaemic long-term synaptic potentiation in the striatum: a putative mechanism for cell type-specific vulnerability
    Paolo Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata and IRCCS Fondazione Santa Lucia, Rome, Italy
    Brain 125:844-60. 2002
    ..We suggest that i-LTP represents a pathological form of synaptic plasticity that may account for the cell type-specific vulnerability observed in striatal spiny neurones following ischaemia and energy deprivation...
  2. ncbi request reprint Is pharmacological neuroprotection dependent on reduced glutamate release?
    P Calabresi
    Clinica Neurologica, Dipartimiento Neuroscienze, Universita di Tor Vergata, Rome, Italy
    Stroke 31:766-72; discussion 773. 2000
    ....
  3. ncbi request reprint Electrophysiology of sipatrigine: a lamotrigine derivative exhibiting neuroprotective effects
    P Calabresi
    Clinica Neurologica, Universita Tor Vergata, Rome, 00133, Italy
    Exp Neurol 162:171-9. 2000
    ....
  4. ncbi request reprint Synaptic transmission in the striatum: from plasticity to neurodegeneration
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Tor Vergata 135, 00133, Rome, Italy
    Prog Neurobiol 61:231-65. 2000
    ..These ionic mechanisms might partially explain the selective neuronal vulnerability observed in the striatum during global ischemia and Huntington's disease...
  5. ncbi request reprint Ionotropic glutamate receptors: still a target for neuroprotection in brain ischemia? Insights from in vitro studies
    Paolo Calabresi
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neurobiol Dis 12:82-8. 2003
    ..In addition, our findings support the concept that it is possible to produce a significant neuroprotective action in the absence of a relevant interference with normal synaptic transmission...
  6. ncbi request reprint Tissue plasminogen activator controls multiple forms of synaptic plasticity and memory
    P Calabresi
    Clinica Neurologica, Dip Neuroscienze, Universita di Tor Vergata, Via di Tor Vergata 135, Rome 00133, Italy
    Eur J Neurosci 12:1002-12. 2000
    ..These data indicate that t-PA plays a critical role in the formation of various forms of synaptic plasticity and memory...
  7. ncbi request reprint Dopamine and cAMP-regulated phosphoprotein 32 kDa controls both striatal long-term depression and long-term potentiation, opposing forms of synaptic plasticity
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Rome, Italy
    J Neurosci 20:8443-51. 2000
    ..These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations...
  8. ncbi request reprint Cellular factors controlling neuronal vulnerability in the brain: a lesson from the striatum
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, and the IRCCS, S Lucia, Rome, Italy
    Neurology 55:1249-55. 2000
    ..Specific molecules able to target these cellular factors might be employed as therapeutic agents during acute and chronic neurologic disorders affecting this brain area...
  9. ncbi request reprint Activation of metabotropic glutamate receptor subtype 1/protein kinase C/mitogen-activated protein kinase pathway is required for postischemic long-term potentiation in the striatum
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Roma, Italy
    Mol Pharmacol 60:808-15. 2001
    ....
  10. ncbi request reprint Antiepileptic drugs as a possible neuroprotective strategy in brain ischemia
    Paolo Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Ann Neurol 53:693-702. 2003
    ....
  11. ncbi request reprint Pharmacological inhibition of the Na(+)/Ca(2+) exchanger enhances depolarizations induced by oxygen/glucose deprivation but not responses to excitatory amino acids in rat striatal neurons
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome
    Stroke 30:1687-94. 1999
    ..However, the role of this exchanger in excitotoxicity and ischemia-induced neuronal injury is still controversial and has never been studied in the same neuronal subtypes...
  12. pmc Muscarinic IPSPs in rat striatal cholinergic interneurones
    P Calabresi
    Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    J Physiol 510:421-7. 1998
    ..6. The findings demonstrate that muscarinic IPSPs occur in the central nervous system. The IPSP may mediate an 'autoinhibition' of striatal cholinergic neurone activity...
  13. ncbi request reprint Endogenous ACh enhances striatal NMDA-responses via M1-like muscarinic receptors and PKC activation
    P Calabresi
    Clinica Neurologica, Dip Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Eur J Neurosci 10:2887-95. 1998
    ..Our data show that endogenous striatal ACh exerts a positive modulatory action on NMDA responses via M1-like muscarinic receptors and PKC activation...
  14. ncbi request reprint Medication-overuse headache: similarities with drug addiction
    Paolo Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Trends Pharmacol Sci 26:62-8. 2005
    ..An integrative hypothesis for compulsive reward-seeking in MOH will be presented...
  15. ncbi request reprint Synaptic plasticity in the ischaemic brain
    Paolo Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and the IRCCS Fondazione Santa Lucia, Rome, Italy
    Lancet Neurol 2:622-9. 2003
    ..We discuss evidence that ischaemia could also induce protective and reparative forms of neuronal plasticity that may play a part in ischaemic tolerance and poststroke recovery...
  16. pmc An in vitro electrophysiological study on the effects of phenytoin, lamotrigine and gabapentin on striatal neurons
    P Calabresi
    Dip Sanità, Universita di Roma Tor Vergata, Rome, Italy
    Br J Pharmacol 126:689-96. 1999
    ....
  17. ncbi request reprint Lamotrigine and remacemide protect striatal neurons against in vitro ischemia: an electrophysiological study
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Exp Neurol 182:461-9. 2003
    ..A combined use of lamotrigine and remacemide could be employed in clinical trials to enhance neuroprotection in neurological disorders involving an abnormal striatal glutamatergic transmission...
  18. ncbi request reprint Inhibition of mitochondrial complex II induces a long-term potentiation of NMDA-mediated synaptic excitation in the striatum requiring endogenous dopamine
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, , Rome 00133, Italy
    J Neurosci 21:5110-20. 2001
    ..Thus 3-NP-LTP might play a key role in the regional and cell type-specific neuronal death observed in HD...
  19. ncbi request reprint Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons
    A Pisani
    Clinica Neurologica, Dipartmento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuroscience 106:579-87. 2001
    ....
  20. ncbi request reprint An abnormal striatal synaptic plasticity may account for the selective neuronal vulnerability in Huntington's disease
    D Centonze
    Neurosciences Department, University of Rome Tor Vergata, Rome, Italy
    Neurol Sci 22:61-2. 2001
    ..This pathological form of corticostriatal synaptic plasticity might play a key role in the regional and cell-type specific neuronal death observed in HD...
  21. ncbi request reprint Stimulation of nitric oxide-cGMP pathway excites striatal cholinergic interneurons via protein kinase G activation
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, , 00133 Rome, Italy
    J Neurosci 21:1393-400. 2001
    ..The characterization of the cellular mechanisms involved in the regulation of striatal interneuron activity is a key step for the understanding of the role of these cells in striatal microcircuitry...
  22. ncbi request reprint A synaptic mechanism underlying the behavioral abnormalities induced by manganese intoxication
    P Calabresi
    Clinica Neurologica, Dipartemente Neuroscienze, Universita' di Roma Tor Vergata, Via di Tor Vergata 135, Rome, 00133, Italy
    Neurobiol Dis 8:419-32. 2001
    ....
  23. ncbi request reprint Corticostriatal LTP requires combined mGluR1 and mGluR5 activation
    P Gubellini
    Istituto di Neurobiologia e Medicina Molecolare, CNR, Rome, Italy
    Neuropharmacology 44:8-16. 2003
    ....
  24. ncbi request reprint L-type Ca2+ channel blockers attenuate electrical changes and Ca2+ rise induced by oxygen/glucose deprivation in cortical neurons
    A Pisani
    Clinica Neurologica, Dipartimento di Sanita, Universita Tor Vergata, and Ospedale S Lucia, IRCCS, Rome, Italy
    Stroke 29:196-201; discussion 202. 1998
    ..To clarify further the role and the origin of Ca2+ in cerebral ischemia, we have studied the effects of various pharmacological agents in an in vitro model of oxygen (O2)/glucose deprivation...
  25. ncbi request reprint Deficits of glutamate transmission in the striatum of experimental hemiballism
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 143:213-21. 2006
    ....
  26. ncbi request reprint Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons
    P Bonsi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, C E R C, Rome, Italy
    Neuropharmacology 49:104-13. 2005
    ..Together, these data suggest that mGluR5 modulates mGluR1 activity to shape cell excitability...
  27. ncbi request reprint Enhanced sensitivity of DJ-1-deficient dopaminergic neurons to energy metabolism impairment: role of Na+/K+ ATPase
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Roma, Italy
    Neurobiol Dis 23:54-60. 2006
    ..These findings suggest that DJ-1 loss-of-function enhances vulnerability to energy metabolism alterations, and that nigral neurons are particularly sensitive to Na+/K+ ATPase impairment...
  28. ncbi request reprint Striatal metabotropic glutamate receptors as a target for pharmacotherapy in Parkinson's disease
    P Bonsi
    Laboratorio di Neurofisiologia, I R C C S Fondazione Santa Lucia C E R C, European Brain Research Institute, Rome, Italy
    Amino Acids 32:189-95. 2007
    ..Thus, targeting mGluRs located onto cholinergic interneurons might result in a beneficial pharmacological effect in the parkinsonian state...
  29. ncbi request reprint Adenosine-mediated inhibition of striatal GABAergic synaptic transmission during in vitro ischaemia
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, , Rome, Italy
    Brain 124:1855-65. 2001
    ..The early depression of GABA-mediated synaptic transmission might play a role in the development of irreversible neuronal injury in the course of brain ischaemia...
  30. ncbi request reprint Activation of D2-like dopamine receptors reduces synaptic inputs to striatal cholinergic interneurons
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 20:RC69. 2000
    ....
  31. ncbi request reprint Early ionic and membrane potential changes caused by the pesticide rotenone in striatal cholinergic interneurons
    P Bonsi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Fondazione Santa Lucia, IRCCS, 00133 Rome, Italy
    Exp Neurol 185:169-81. 2004
    ..In turn, the hyperpolarizing response might be generated both by the opening of ATP-sensitive K+ channels and by Na+-activated K+ conductances. The increase in [Ca2+]i occurs lately and does not seem to influence the early events...
  32. ncbi request reprint Functional coexpression of excitatory mGluR1 and mGluR5 on striatal cholinergic interneurons
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuropharmacology 40:460-3. 2001
    ..The response to 3,5-DHPG was blocked only by the coadministration of mGluR1 and mGluR5 antagonists, suggesting that both mGluRs are involved in this excitatory effect in striatal cholinergic interneurons...
  33. ncbi request reprint Activation of beta1-adrenoceptors excites striatal cholinergic interneurons through a cAMP-dependent, protein kinase-independent pathway
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    J Neurosci 23:5272-82. 2003
    ..We conclude that NA depolarizes striatal cholinergic interneurons via beta1-adrenoceptor activation, through a cAMP-dependent but PKA-independent mechanism...
  34. ncbi request reprint Differential contribution of dopamine D2S and D2L receptors in the modulation of glutamate and GABA transmission in the striatum
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 129:157-66. 2004
    ..Understanding the physiological roles of DA D2 receptors in the striatum is essential for the treatment of several neuropsychiatric conditions, such as Parkinson's disease, Tourette's syndrome, schizophrenia, and drug addiction...
  35. doi request reprint Induction of heat shock protein 70 reduces the alteration of striatal electrical activity caused by mitochondrial impairment
    M Tantucci
    Dipartimento di Specialità Medico Chirurgiche e Sanità Pubblica, Clinica Neurologica, Universita degli Studi di Perugia, Via Enrico Dal Pozzo, 06126 Perugia, Italy
    Neuroscience 163:735-40. 2009
    ....
  36. ncbi request reprint Dopaminergic control of synaptic plasticity in the dorsal striatum
    D Centonze
    Clinica Neurologica, Dip. Neuroscienze, , Via di Tor Vergata 135, Rome 00133, Italy
    Eur J Neurosci 13:1071-7. 2001
    ..These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations...
  37. ncbi request reprint Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP
    P Calabresi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita degli Studi di Roma, Italy
    Neuropharmacology 38:323-6. 1999
    ....
  38. ncbi request reprint Impaired excitatory transmission in the striatum of rats chronically intoxicated with manganese
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita' Tor Vergata, Via di Tor Vergata 135, Rome, 00133, Italy
    Exp Neurol 172:469-76. 2001
    ..It is concluded, therefore, that hyperactivity of corticostriatal neurons, rather than increased postsynaptic sensitivity to glutamate, accounts for the abnormal excitation of striatal neurons in the course of Mn intoxication...
  39. ncbi request reprint Modulation of gene expression following long-term synaptic depression in the striatum
    M Napolitano
    Department of Experimental Medicine and Pathology, University La Sapienza, Viale Regina Elena 324, 00161, Rome, Italy
    Brain Res Mol Brain Res 72:89-96. 1999
    ..Our data suggest that a complex pattern of genes acting at presynaptic level and extracellularly may be involved in LTD-associated synaptic remodeling...
  40. ncbi request reprint Blockade of M2-like muscarinic receptors enhances long-term potentiation at corticostriatal synapses
    P Calabresi
    Clinica Neurologica, Dip Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Eur J Neurosci 10:3020-3. 1998
    ....
  41. ncbi request reprint Cell-type specificity of mGluR activation in striatal neuronal subtypes
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Amino Acids 19:119-29. 2000
    ....
  42. doi request reprint Antiepileptic drugs on calcium currents recorded from cortical and PAG neurons: therapeutic implications for migraine
    G Martella
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata Rome, Italy
    Cephalalgia 28:1315-26. 2008
    ..The negative modulation of specific subtypes of HVA Ca(2+) channels by various AEDs can restore normal electrical activity in target brain areas such as cortex and PAG, providing interesting therapeutic approaches in migraine prevention...
  43. ncbi request reprint Abnormal synaptic plasticity in the striatum of mice lacking dopamine D2 receptors
    P Calabresi
    Clinica Neurologica, Universita di Roma Tor Vergata, Dipartimento Sanita, 00173 Rome, Italy
    J Neurosci 17:4536-44. 1997
    ..It also shows that an imbalance between D2R and NMDA receptor activity induces altered synaptic plasticity at corticostriatal synapses. This abnormal synaptic plasticity might cause the movement disorders observed in Parkinson's disease...
  44. ncbi request reprint Selective involvement of mGlu1 receptors in corticostriatal LTD
    P Gubellini
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via di Tor Vergata 135, 00133, Rome, Italy
    Neuropharmacology 40:839-46. 2001
    ..mGluR1-mediated control of this form of synaptic plasticity may play a role in the modulatory effect exerted by mGluRs in the basal ganglia-related motor activity...
  45. doi request reprint Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition
    Cinzia Costa
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, 06156 Perugia, Italy
    J Neurosci 28:8040-52. 2008
    ..Differential targeting of GABAergic transmission may represent a possible therapeutic strategy against basal ganglia neurodegenerative disorders involving mitochondrial complex I dysfunction...
  46. ncbi request reprint Endogenous dopamine amplifies ischemic long-term potentiation via D1 receptors
    Emilia Saulle
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, and IRCCS Fondazione Santa Lucia, Rome, Italy
    Stroke 33:2978-84. 2002
    ..In an attempt to clarify how dopamine takes part in ischemia-induced neuronal damage, we performed in vitro electrophysiological recordings from neurons of the nucleus striatum...
  47. ncbi request reprint Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism
    Mauro Maccarrone
    Dipartimento di Medicina Sperimentale e Scienze Biochimiche and Dipartimento di Neuroscienze, Universita degli Studi di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    J Neurochem 85:1018-25. 2003
    ....
  48. ncbi request reprint Targeting striatal cholinergic interneurons in Parkinson's disease: focus on metabotropic glutamate receptors
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Neuropharmacology 45:45-56. 2003
    ..The potential relevance of these findings in the control of motor function and in the treatment of PD will be discussed...
  49. ncbi request reprint Subthalamic nucleus lesion reverses motor abnormalities and striatal glutamatergic overactivity in experimental parkinsonism
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 133:831-40. 2005
    ..Since neither l-DOPA treatment nor STN lesion affected sEPSCs kinetic properties, the reversal of these abnormalities in striatal excitatory synaptic transmission can be attributable to the normalization of glutamate release...
  50. ncbi request reprint Memantine reduces neuronal dysfunctions triggered by in vitro ischemia and 3-nitropropionic acid
    A Tozzi
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Via S Andrea delle Fratte, Perugia 06156, Italy
    Exp Neurol 207:218-26. 2007
    ..Memantine could represent a potential neuroprotective agent in pathophysiological conditions involving an altered energy metabolism of basal ganglia...
  51. ncbi request reprint Cocaine and amphetamine depress striatal GABAergic synaptic transmission through D2 dopamine receptors
    Diego Centonze
    Dipartimento di Neuroscienze, Clinica Neurologica, Università Tor Vergata and Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropsychopharmacology 26:164-75. 2002
    ..The modulation of GABAergic synaptic transmission in the striatum might underlie some motor and cognitive effects of psychostimulants in mammalians...
  52. ncbi request reprint Early sodium elevations induced by combined oxygen and glucose deprivation in pyramidal cortical neurons
    A Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Eur J Neurosci 10:3572-4. 1998
    ..The present results demonstrate that, in cortical neurons, O2/glucose deprivation induces an early rise in [Na+]i which cannot be ascribed to the activity of voltage gated Na+-channels, glutamate receptors or of the Na+/Ca2+-exchanger...
  53. ncbi request reprint Ionic mechanisms underlying differential vulnerability to ischemia in striatal neurons
    D Centonze
    IRCCS Ospedale S. Lucia, Rome, Italy
    Prog Neurobiol 63:687-96. 2001
    ..The understanding of the ionic mechanisms underlying the differential membrane responses to ischemia represents the basis for the development of rational neuroprotective treatments during acute cerebrovascular insults...
  54. pmc TrkB/BDNF-dependent striatal plasticity and behavior in a genetic model of epilepsy: modulation by valproic acid
    Veronica Ghiglieri
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Rome, Italy
    Neuropsychopharmacology 35:1531-40. 2010
    ..Our results provide the first indication that BDNF is involved in determining the striatal alterations occurring in the early-onset epileptic syndrome associated with the absence of presynaptic protein Bassoon...
  55. ncbi request reprint A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata and IRCCS Fondazione Santa Lucia, Rome, Italy
    Neuropsychopharmacology 29:1488-97. 2004
    ..Understanding the molecular and physiological effects of drugs of abuse in the brain is essential for the development of effective strategies against addiction...
  56. ncbi request reprint Neuronal vulnerability following inhibition of mitochondrial complex II: a possible ionic mechanism for Huntington's disease
    Emilia Saulle
    Clinica Neurologica, Dipartimento di Medicina Clinica e Sperimentale, Universita di Ferrara, Ferrara, Italy
    Mol Cell Neurosci 25:9-20. 2004
    ..Conversely, the hyperpolarization did not significantly differ from the one recorded in WT mice. The diverse membrane changes induced by SD inhibition may contribute to the cell-type-specific neuronal death in HD...
  57. ncbi request reprint Distinct roles of D1 and D5 dopamine receptors in motor activity and striatal synaptic plasticity
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, 00133 Rome, Italy
    J Neurosci 23:8506-12. 2003
    ....
  58. ncbi request reprint Coactivation of GABA(A) and GABA(B) receptor results in neuroprotection during in vitro ischemia
    Cinzia Costa
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Rome, Italy
    Stroke 35:596-600. 2004
    ....
  59. doi request reprint Electrophysiological actions of zonisamide on striatal neurons: Selective neuroprotection against complex I mitochondrial dysfunction
    Cinzia Costa
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Exp Neurol 221:217-24. 2010
    ....
  60. ncbi request reprint Deficits of glutamate transmission in the striatum of toxic and genetic models of Huntington's disease
    Silvia Rossi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neurosci Lett 410:6-10. 2006
    ..In both models, we found a significant down-regulation of glutamate transmission, suggesting that reduced synaptic excitation of the input structure of the basal ganglia represents a physiological correlate of HD...
  61. ncbi request reprint Receptor subtypes involved in the presynaptic and postsynaptic actions of dopamine on striatal interneurons
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, 00133 Rome, Italy
    J Neurosci 23:6245-54. 2003
    ....
  62. ncbi request reprint Dopamine excites fast-spiking interneurons in the striatum
    Enrico Bracci
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome 00133, Italy
    J Neurophysiol 87:2190-4. 2002
    ..These results show that endogenous dopamine exerts a dual excitatory action on FS interneurons, by directly depolarizing them (through D1-like receptors) and by reducing their synaptic inhibition (through presynaptic D2-like receptors)...
  63. ncbi request reprint Behavioural learning-induced increase in spontaneous GABAA-dependent synaptic activity in rat striatal cholinergic interneurons
    Paola Bonsi
    Fondazione Santa Lucia IRCCS, Rome and Department of Neuroscience, Neurological Clinic, University Tor Vergata, Rome, Italy
    Eur J Neurosci 17:174-8. 2003
    ..This intrastriatal mechanism might be involved in the phasic suppression of discharge of TANs at the presentation of reward-related sensory stimuli...
  64. doi request reprint Hippocampal synaptic plasticity, memory, and epilepsy: effects of long-term valproic acid treatment
    Carmelo Sgobio
    Fondazione Santa Lucia, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    Biol Psychiatry 67:567-74. 2010
    ....
  65. ncbi request reprint The brain cytoplasmic RNA BC1 regulates dopamine D2 receptor-mediated transmission in the striatum
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    J Neurosci 27:8885-92. 2007
    ....
  66. ncbi request reprint Chronic haloperidol promotes corticostriatal long-term potentiation by targeting dopamine D2L receptors
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, 00133 Rome, Italy
    J Neurosci 24:8214-22. 2004
    ..The identification of the cellular, molecular, and receptor mechanisms involved in the action of haloperidol in the brain is essential to understand how antipsychotic agents exert their beneficial and side effects...
  67. ncbi request reprint Impairment of mitochondrial metabolism differentially affects striatal neuronal subtypes
    A Pisani
    Clinica Neurologica, Universita di Roma Tor Vergata, Via di Tor Vergata 135, 00133 Rome, Italy
    Neuroreport 13:641-4. 2002
    ..The present results indicate that mitochondrial Ca2+ released into the cytosol may contribute to the selective vulnerability to metabolic impairment in striatal neuronal subtypes...
  68. doi request reprint mTOR inhibitor rapamycin suppresses striatal post-ischemic LTP
    Veronica Ghiglieri
    Fondazione Santa Lucia IRCCS, Via del Fosso di Fiorano, 64, 00143, Rome, Italy
    Exp Neurol 226:328-31. 2010
    ..The present results argue for a role of mTOR complex in i-LTP and suggest that rapamycin, by selectively blocking i-LTP, represents a promising therapeutic tool to limit cellular damage after ischemic brain insult...
  69. ncbi request reprint NR2B subunit exerts a critical role in postischemic synaptic plasticity
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, Rome, Italy
    Stroke 37:1895-901. 2006
    ..We characterized the differential effect of the NR2B subunit antagonist ifenprodil in the induction of activity-dependent long-term potentiation (LTP) and of postischemic LTP as well as in the neuronal damage induced by focal ischemia...
  70. ncbi request reprint Abnormal Ca2+-calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 24:5283-91. 2004
    ..Normalization of CaMKII activity may be an important underlying mechanism of the therapeutic action of L-DOPA in PD...
  71. ncbi request reprint Activation of dopamine D1-like receptors excites LTS interneurons of the striatum
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via di Tor Vergata, 135, 00133 Rome, Italy
    Eur J Neurosci 15:2049-52. 2002
    ..In addition, this pharmacological effect was mimicked by D1- but not D2-like DA receptor agonists, implying the selective involvement of D1-like receptors in this action...
  72. ncbi request reprint Morphological and functional study of dwarf neurons in the rat striatum
    G Sancesario
    Laboratorio di Neuroscienze, Universita di Roma Tor Vergata, Lucia, Rome
    Eur J Neurosci 10:3575-83. 1998
    ..9% of the recorded neurons). These data suggest that some neurogliaform cells in the striatum of young rat can be identified as dwarf interneurons, that may be dye-coupled with neurons of different classes...
  73. ncbi request reprint Inhibition of persistent sodium current fraction and voltage-gated L-type calcium current by propofol in cortical neurons: implications for its antiepileptic activity
    Giuseppina Martella
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Epilepsia 46:624-35. 2005
    ..We examined the electrophysiologic effects of propofol on an in vitro model of epileptic activity obtained from a slice preparation...
  74. doi request reprint Short-term and long-term plasticity at corticostriatal synapses: implications for learning and memory
    Massimiliano Di Filippo
    Clinica Neurologica, Laboratori di Neurologia Sperimentale, Universita di Perugia, Perugia, Italy
    Behav Brain Res 199:108-18. 2009
    ....
  75. ncbi request reprint l-DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS c o CERC, Rome, Italy
    Neurobiol Dis 29:327-35. 2008
    ....
  76. ncbi request reprint Inhibition of mitochondrial complex II alters striatal expression of genes involved in glutamatergic and dopaminergic signaling: possible implications for Huntington's disease
    Maddalena Napolitano
    Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Rome, Italy
    Neurobiol Dis 15:407-14. 2004
    ..Our data provide new information about the molecular events possibly underlying neurodegeneration induced by this mitochondrial toxin...
  77. ncbi request reprint Dopamine, acetylcholine and nitric oxide systems interact to induce corticostriatal synaptic plasticity
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Rev Neurosci 14:207-16. 2003
    ....
  78. ncbi request reprint Long-term potentiation and memory processes in the psychological works of Sigmund Freud and in the formation of neuropsychiatric symptoms
    D Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Neuroscience 130:559-65. 2005
    ..Freud's insights did not stop here, but went on to describe in an extremely precise manner the neural mechanisms of memory formation almost a century before the description of long-term synaptic potentiation...
  79. ncbi request reprint Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, I R C C S Fondazione Santa Lucia, Italy
    Brain 125:2635-45. 2002
    ..We suggest that an enhanced sensitivity of pre-synaptic inhibitory mGlu2/3 receptors might represent an adaptive change triggered by dopaminergic denervation, which can be reversed by L-DOPA treatment...
  80. ncbi request reprint Levetiracetam monotherapy in Alzheimer patients with late-onset seizures: a prospective observational study
    V Belcastro
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Eur J Neurol 14:1176-8. 2007
    ..These results suggest the need for controlled studies to confirm if LEV can be a first-choice drug in AD...
  81. ncbi request reprint Tissue plasminogen activator is required for striatal post-ischemic synaptic potentiation
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Neuroreport 13:115-8. 2002
    ..The absence of striatal post-ischemic pote ntiat ion observed in tPA-lacking mice may account for the significant neuroprotection observed in these animals after the occlusion of middle cerebral artery...
  82. ncbi request reprint The endocannabinoid system in Parkinson's disease
    Massimiliano Di Filippo
    Clinica Neurologica, Ospedale S Maria della Misericordia, Universita di Perugia, 06156 Perugia, Italy
    Curr Pharm Des 14:2337-47. 2008
    ....
  83. ncbi request reprint Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Nat Neurosci 6:501-6. 2003
    ..These results indicate that abnormal information storage in corticostriatal synapses is linked with the development of L-DOPA-induced dyskinesia...
  84. ncbi request reprint Experimental parkinsonism modulates multiple genes involved in the transduction of dopaminergic signals in the striatum
    Maddalena Napolitano
    Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Rome, Italy
    Neurobiol Dis 10:387-95. 2002
    ....
  85. ncbi request reprint Tissue plasminogen activator is required for corticostriatal long-term potentiation
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
    Eur J Neurosci 16:713-21. 2002
    ....
  86. doi request reprint A novel spinocerebellar ataxia type 15 family with involuntary movements and cognitive decline
    A Castrioto
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Eur J Neurol 18:1263-5. 2011
    ..SCA15 is a recently identified spinocerebellar ataxia with pure cerebellar involvement. Here, we report a novel SCA15 Italian family with atypical clinical features...
  87. doi request reprint A magnetization transfer study of mild and advanced Parkinson's disease
    N Tambasco
    Clinica Neurologica, Azienda Ospedaliera Università di Perugia, Italy
    Eur J Neurol 18:471-7. 2011
    ..However, how these tissue changes differ along the course of the illness is still unclear. This study was aimed at investigating how MTR values change from mild PD (PD1) to patients with advanced PD (PD2)...
  88. ncbi request reprint Dopamine-mediated regulation of corticostriatal synaptic plasticity
    Paolo Calabresi
    Clinica Neurologica, Universita di Perugia, Ospedale S Maria della Misericordia, Via S Andrea delle Fratte, 06156, Perugia, Italy
    Trends Neurosci 30:211-9. 2007
    ..Finally, we discuss how endogenous dopamine crucially influences changes in synaptic plasticity induced by pathological stimuli, such as energy deprivation...
  89. ncbi request reprint Synaptic plasticity during recovery from permanent occlusion of the middle cerebral artery
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Neurobiol Dis 27:44-53. 2007
    ..Our results provide a synaptic correlate of the long-lasting brain hyperexcitability mediating recovery described with noninvasive neurophysiological approaches...
  90. ncbi request reprint NR2B-containing NMDA receptors promote the neurotoxic effects of 3-nitropropionic acid but not of rotenone in the striatum
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, 00133 Rome, Italy
    Exp Neurol 202:470-9. 2006
    ....
  91. ncbi request reprint Metabotropic glutamate 2 receptors modulate synaptic inputs and calcium signals in striatal cholinergic interneurons
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 22:6176-85. 2002
    ..These results suggest that the mGlu2 receptor-mediated modulatory action on cell excitability would tune striatal ACh release, representing an interesting target for pharmacological intervention in basal ganglia disorders...
  92. doi request reprint Striatal synaptic changes in experimental parkinsonism: role of NMDA receptor trafficking in PSD
    Barbara Picconi
    Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS c o CERC, Via del Fosso di Fiorano 64, Rome, Italy
    Parkinsonism Relat Disord 14:S145-9. 2008
    ....
  93. ncbi request reprint Striatal synaptic plasticity: implications for motor learning and Parkinson's disease
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata and Fondazione Santa Lucia, I R C C S, Roma, Italy
    Mov Disord 20:395-402. 2005
    ..The potential relevance of these findings in the control of motor function and in the pathogenesis both of PD and L-dopa-induced motor complications will be discussed...
  94. ncbi request reprint Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission
    Paolo Gubellini
    Dipartimentos di Neuroscienze, Universita degli Studi di Roma Tor Vergata, 00133 Roma, Italy
    J Neurosci 22:6900-7. 2002
    ..The present study shows that inhibition of anandamide hydrolysis might represent a possible target to decrease the abnormal cortical glutamatergic drive in Parkinson's disease...
  95. ncbi request reprint Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemia
    Cinzia Costa
    Clinica Neurologica, Universita di Perugia, Ospedale Silvestrini, S Andrea delle Fratte, Perugia, Italy
    Stroke 37:1319-26. 2006
    ..In particular, the aim of the study was to correlate the putative neuroprotective effects with the action of these drugs on fast sodium (Na+) and high-voltage-activated (HVA) calcium (Ca2+) currents...
  96. doi request reprint Impaired plasticity at specific subset of striatal synapses in the Ts65Dn mouse model of Down syndrome
    Massimiliano Di Filippo
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Via S Andrea delle Fratte, 06156 Perugia, Italy
    Biol Psychiatry 67:666-71. 2010
    ....
  97. ncbi request reprint The Project for a Scientific Psychology (1895): a Freudian anticipation of LTP-memory connection theory
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Brain Res Brain Res Rev 46:310-4. 2004
    ..In the present article we aim at presenting Freudian theory on the functional organization of the nervous system developed in the Project, with particular respect to his ideas of the cellular bases of memory...
  98. ncbi request reprint Pathological synaptic plasticity in the striatum: implications for Parkinson's disease
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata and Fondazione Santa Lucia, I R C C S, Via di Tor Vergata 135, Roma, Italy
    Neurotoxicology 26:779-83. 2005
    ..The potential relevance of these findings in the control of motor function and in the pathogenesis both of Parkinson's disease and l-dopa-induced motor complications will be discussed...
  99. ncbi request reprint Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striatum of R6/2 Huntington's disease mice
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Tor Vergata, Italy
    Biol Psychiatry 57:1583-9. 2005
    ..How this alteration impacts striatal synaptic transmission is unknown...
  100. ncbi request reprint Intracellular calcium increase in epileptiform activity: modulation by levetiracetam and lamotrigine
    Antonio Pisani
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Rome, Italy
    Epilepsia 45:719-28. 2004
    ..Levetiracetam (LEV) and lamotrigine (LTG), novel antiepileptic drugs (AEDs), were tested on epileptiform events and the corresponding elevations in intracellular Ca2+ concentration ([Ca2+]i) recorded from rat neocortical slices...
  101. ncbi request reprint Removing pathogenic memories: a neurobiology of psychotherapy
    Diego Centonze
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita Tor Vergata, Rome, Italy
    Mol Neurobiol 32:123-32. 2005
    ....