V Calabrese

Summary

Affiliation: University of Catania
Country: Italy

Publications

  1. doi request reprint Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes
    V Calabrese
    Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    Biochim Biophys Acta 1822:729-36. 2012
  2. ncbi request reprint Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease
    Vittorio Calabrese
    Department of Chemistry, Biochemistry, and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    Antioxid Redox Signal 8:1975-86. 2006
  3. ncbi request reprint Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: evidence for a protective role of acetylcarnitine
    V Calabrese
    Department of Chemistry, Section of Biochemistry and Molecular Biology Faculty of Medicine, University of Catania, Catania, Italy
    Neurochem Res 28:1321-8. 2003
  4. ncbi request reprint Redox regulation of heat shock protein expression in aging and neurodegenerative disorders associated with oxidative stress: a nutritional approach
    V Calabrese
    Department of Chemistry, Section of Biochemistry and Molecular Biology, Faculty of Medicine, University of Catania, Catania, Italy
    Amino Acids 25:437-44. 2003
  5. ncbi request reprint Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state
    V Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Viale Andrea Doria No 6, 95100 Catania, Italy
    Mech Ageing Dev 125:325-35. 2004
  6. ncbi request reprint Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease
    Vittorio Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    Ital J Biochem 52:177-81. 2003
  7. ncbi request reprint Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders: the role of vitagenes
    Vittorio Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    In Vivo 18:245-67. 2004
  8. doi request reprint Curcumin and the cellular stress response in free radical-related diseases
    Vittorio Calabrese
    Department of Chemistry, Clinical Biochemistry and Clinical Molecular Biology Chair, University of Catania, Catania, Italy
    Mol Nutr Food Res 52:1062-73. 2008
  9. ncbi request reprint Increased formation of short-chain organic acids after chronic ethanol administration and its interaction with the carnitine pool in rat
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Mol Biology Section, Faculty of Medicine, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Arch Biochem Biophys 431:271-8. 2004
  10. ncbi request reprint Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    J Neurosci Res 79:509-21. 2005

Collaborators

Detail Information

Publications80

  1. doi request reprint Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes
    V Calabrese
    Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    Biochim Biophys Acta 1822:729-36. 2012
    ..This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease...
  2. ncbi request reprint Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease
    Vittorio Calabrese
    Department of Chemistry, Biochemistry, and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    Antioxid Redox Signal 8:1975-86. 2006
    ..Our data support a role for nitrative stress in the pathogenesis of AD and indicate that the stress-responsive genes, such as HO-1 and TRXr, may represent important targets for novel cytoprotective strategies...
  3. ncbi request reprint Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: evidence for a protective role of acetylcarnitine
    V Calabrese
    Department of Chemistry, Section of Biochemistry and Molecular Biology Faculty of Medicine, University of Catania, Catania, Italy
    Neurochem Res 28:1321-8. 2003
    ....
  4. ncbi request reprint Redox regulation of heat shock protein expression in aging and neurodegenerative disorders associated with oxidative stress: a nutritional approach
    V Calabrese
    Department of Chemistry, Section of Biochemistry and Molecular Biology, Faculty of Medicine, University of Catania, Catania, Italy
    Amino Acids 25:437-44. 2003
    ..Consistent with this notion, maintenance or recovery of the activity of vitagenes, such as the HO gene, conceivably may delay the aging process and decrease the occurrence of age-related neurodegenerative diseases...
  5. ncbi request reprint Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state
    V Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Viale Andrea Doria No 6, 95100 Catania, Italy
    Mech Ageing Dev 125:325-35. 2004
    ..Conceivably, heat shock signal pathway by increasing cellular stress resistance may represent a crucial mechanism of defence against free radical-induced damage occurring in aging brain and in neurodegenerative disorders...
  6. ncbi request reprint Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease
    Vittorio Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    Ital J Biochem 52:177-81. 2003
    ..Such an outcome would provide optimism that the signs and symptoms of this devastating brain disorder of aging may be largely delayed and/or modulated...
  7. ncbi request reprint Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders: the role of vitagenes
    Vittorio Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    In Vivo 18:245-67. 2004
    ..Consistent with this notion, maintenance or recovery of the activity of vitagenes may possibly delay the aging process and decrease the occurrence of age-related diseases with resulting prolongation of a healthy life span...
  8. doi request reprint Curcumin and the cellular stress response in free radical-related diseases
    Vittorio Calabrese
    Department of Chemistry, Clinical Biochemistry and Clinical Molecular Biology Chair, University of Catania, Catania, Italy
    Mol Nutr Food Res 52:1062-73. 2008
    ..This review outlines the biological activities of curcumin and discusses its potential use in the prevention and treatment of human diseases...
  9. ncbi request reprint Increased formation of short-chain organic acids after chronic ethanol administration and its interaction with the carnitine pool in rat
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Mol Biology Section, Faculty of Medicine, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Arch Biochem Biophys 431:271-8. 2004
    ....
  10. ncbi request reprint Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    J Neurosci Res 79:509-21. 2005
    ..We hypothesize that maintenance or recovery of the activity of vitagenes may delay the aging process and decrease the risk of age-related diseases...
  11. doi request reprint Redox regulation of cellular stress response by ferulic acid ethyl ester in human dermal fibroblasts: role of vitagenes
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, 95100 Catania, Italy
    Clin Dermatol 26:358-63. 2008
    ..These findings provide evidence for the protective role of vitagenes in free radical-induced skin damage and highlight the potential protective use of nutritional antioxidants, such as ferulic acid and its derivatives...
  12. ncbi request reprint Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich's ataxia
    Vittorio Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Viale Andrea Doria 6, 95100 Catania, Italy
    J Neurol Sci 233:145-62. 2005
    ....
  13. pmc Oxidative stress and cellular stress response in diabetic nephropathy
    Vittorio Calabrese
    Department of Chemistry, Faculty of Medicine, University of Catania, 95100 Catania, Italy
    Cell Stress Chaperones 12:299-306. 2007
    ....
  14. ncbi request reprint Redox regulation of cellular stress response in neurodegenerative disorders
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Mol Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    Ital J Biochem 55:263-82. 2006
    ..This review summarizes the complex regulation of cellular stress signaling and its relevance to human physiology and disease...
  15. ncbi request reprint Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, 95100 Catania, Italy
    J Nutr Biochem 17:73-88. 2006
    ....
  16. ncbi request reprint In vivo induction of heat shock proteins in the substantia nigra following L-DOPA administration is associated with increased activity of mitochondrial complex I and nitrosative stress in rats: regulation by glutathione redox state
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    J Neurochem 101:709-17. 2007
    ..Our data are in favor of the importance of the heat shock signal pathway as a basic mechanism of defense against neurotoxicity elicited by free radical oxygen and nitrogen species produced in aging and neurodegenerative disorders...
  17. ncbi request reprint Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes
    Vittorio Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Viale Andrea Doria 6, 95100, Catania, Italy
    Neurochem Res 32:757-73. 2007
    ..We review here some of the emerging concepts of pathways to neurodegeneration and how these may be overcome by a nutritional approach...
  18. ncbi request reprint Redox regulation in neurodegeneration and longevity: role of the heme oxygenase and HSP70 systems in brain stress tolerance
    Vittorio Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    Antioxid Redox Signal 6:895-913. 2004
    ..Consistently, by maintaining or recovering the activity of vitagenes, it is feasible to delay the aging process and decrease the occurrence of age-related diseases with resulting prolongation of a healthy life span...
  19. ncbi request reprint Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity
    V Calabrese
    Department of Chemistry, Faculty of Medicine, University of Catania, Italy
    Neurochem Res 26:739-64. 2001
    ....
  20. ncbi request reprint Regulation of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: role of vitamin E
    V Calabrese
    Biochemistry and Molecular Biology Section, Department of Chemistry, University of Catania, Italy
    Int J Tissue React 23:127-35. 2001
    ..Exogenous antioxidant supplementation with vitamin E could have cosmetic benefits and may be an efficient tool to mitigate the consequences of free radical-induced skin damage...
  21. ncbi request reprint Effects of acetyl-L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat
    V Calabrese
    Department of Chemistry, Faculty of Medicine, University of Catania, Italy
    Neurochem Res 26:167-74. 2001
    ..These results suggest a potentially important pharmacological role for acetyl-L-carnitine in the prevention of alcohol-induced cellular damage...
  22. ncbi request reprint Molecular chaperones and their roles in neural cell differentiation
    V Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Italy
    Dev Neurosci 24:1-13. 2002
    ..Moreover, the function of Hsps in cell signaling, protein transport and the effect of heat shock on neural plate induction and brain development are discussed...
  23. ncbi request reprint Induction of heat shock protein synthesis in human skin fibroblasts in response to oxidative stress: regulation by a natural antioxidant from rosemary extract
    V Calabrese
    Biochemistry and Molecular Biology Section, Faculty of Medicine, Department of Chemistry, University of Catania, Viale Andrea Doria 6, 95100 Catania, Italy
    Int J Tissue React 23:51-8. 2001
    ..Exogenous supplementation of an antioxidant hydrophilic extract from rosemary could have cosmetic benefits and may represent an efficient tool to minimize free radical-induced skin damage...
  24. ncbi request reprint Nitric oxide synthase induction in astroglial cell cultures: effect on heat shock protein 70 synthesis and oxidant/antioxidant balance
    V Calabrese
    Biochemistry, Faculty of Medicine, University of Catania, Italy
    J Neurosci Res 60:613-22. 2000
    ....
  25. ncbi request reprint Formation of propionate after short-term ethanol treatment and its interaction with the carnitine pool in rat
    V Calabrese
    Biochemistry, Faculty of Medicine, University of Catania, Italy
    Alcohol 19:169-76. 1999
    ..This study suggests that endogenous carnitine pool might play a role against the deleterious effects of accumulating short-chain organic acids...
  26. ncbi request reprint Effects of L-carnitine on the formation of fatty acid ethyl esters in brain and peripheral organs after short-term ethanol administration in rat
    V Calabrese
    Institute of Biochemistry, University of Catania, Italy
    Neurochem Res 24:79-84. 1999
    ....
  27. ncbi request reprint Long-term ethanol administration enhances age-dependent modulation of redox state in different brain regions in the rat: protection by acetyl carnitine
    V Calabrese
    Biochemistry and Molecular Biology Section, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    Int J Tissue React 24:97-104. 2002
    ..Administration of acetyl carnitine greatly reduces these metabolic abnormalities. This evidence supports the pharmacological potential of acetyl carnitine in the management of alcoholic disturbances...
  28. ncbi request reprint Regional distribution of heme oxygenase, HSP70, and glutathione in brain: relevance for endogenous oxidant/antioxidant balance and stress tolerance
    V Calabrese
    Department of Chemistry, Section of Biochemistry and Molecular Biology, Faculty of Medicine, University of Catania, Catania, Italy
    J Neurosci Res 68:65-75. 2002
    ..These data support the hypothesis that the glutathione redox state and basal peroxides can directly participate in the signaling pathways of heat shock protein expression and hence of stress tolerance...
  29. ncbi request reprint Protective effect of carnosine during nitrosative stress in astroglial cell cultures
    V Calabrese
    Department of Chemical Sciences, University of Catania, Italy
    Neurochem Res 30:797-807. 2005
    ..Our results sustain the possibility that carnosine might have anti-ageing effects to brain cells under pathophysiological conditions leading to degenerative damage, such as aging and neurodegenerative disorders...
  30. ncbi request reprint Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: relationship to antioxidant status and mitochondrial function
    V Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    Antioxid Redox Signal 8:404-16. 2006
    ..Particularly, modulation of endogenous cellular defense mechanisms via acetyl-L-carnitine may represent an innovative approach to therapeutic intervention in diseases causing tissue damage, such as neurodegeneration...
  31. ncbi request reprint Biochemical studies of a natural antioxidant isolated from rosemary and its application in cosmetic dermatology
    V Calabrese
    Department of Biochemistry, Faculty of Medicine, University of Catania, Italy
    Int J Tissue React 22:5-13. 2000
    ....
  32. ncbi request reprint Biochemical studies on a novel antioxidant from lemon oil and its biotechnological application in cosmetic dermatology
    V Calabrese
    Faculty of Medicine, Dept of Chemistry, University of Catania, Italy
    Drugs Exp Clin Res 25:219-25. 1999
    ....
  33. ncbi request reprint Oxidative stress and antioxidants at skin biosurface: a novel antioxidant from lemon oil capable of inhibiting oxidative damage to the skin
    V Calabrese
    Faculty of Medicine, Department of Chemistry, University of Catania, Italy
    Drugs Exp Clin Res 25:281-7. 1999
    ....
  34. ncbi request reprint Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity
    Vittorio Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    Antioxid Redox Signal 8:444-77. 2006
    ....
  35. ncbi request reprint Caffeic acid phenethyl ester and curcumin: a novel class of heme oxygenase-1 inducers
    G Scapagnini
    Department of Biochemistry, Section of Biochemistry and Molecular Biology, Faculty of Medicine, University of Catania, Italy corrected
    Mol Pharmacol 61:554-61. 2002
    ..This study identifies a novel class of natural substances that could be used for therapeutic purposes as potent inducers of HO-1 in the protection of tissues against inflammatory and neurodegenerative conditions...
  36. doi request reprint Redox regulation of cellular stress response in multiple sclerosis
    G Pennisi
    Department of Neuroscience, University of Catania, I 95125 Catania, Italy
    Biochem Pharmacol 82:1490-9. 2011
    ....
  37. ncbi request reprint The hormetic role of dietary antioxidants in free radical-related diseases
    V Calabrese
    Department of Chemistry, University of Catania, Catania, Italy
    Curr Pharm Des 16:877-83. 2010
    ....
  38. doi request reprint Redox homeostasis and cellular stress response in aging and neurodegeneration
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    Methods Mol Biol 610:285-308. 2010
    ....
  39. ncbi request reprint Curcumin activates defensive genes and protects neurons against oxidative stress
    Giovanni Scapagnini
    Institute of Neurological Sciences, National Research Council CNR, Catania, Italy
    Antioxid Redox Signal 8:395-403. 2006
    ..This study gives additional support to the possible use of curcumin as a dietary preventive agent against oxidative stress-related diseases...
  40. ncbi request reprint Chronic exposure to high leucine impairs glucose-induced insulin release by lowering the ATP-to-ADP ratio
    M Anello
    Institute of Internal Medicine, Endocrinology, and Metabolism and S Signorelli Diabetes Center, Ospedale Garibaldi, Italy
    Am J Physiol Endocrinol Metab 281:E1082-7. 2001
    ..The abnormal plasma amino acid levels often present in obesity and diabetes may, therefore, affect pancreatic islet insulin secretion in these patients...
  41. pmc Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders
    Vittorio Calabrese
    Department of Chemistry, University of Catania, Italy
    Antioxid Redox Signal 13:1763-811. 2010
    ..Particular attention is given to the emerging role of nitric oxide, carbon monoxide, and hydrogen sulfide gases in hormetic-based neuroprotection and their relationship to membrane radical dynamics and mitochondrial redox signaling...
  42. doi request reprint Cellular stress responses, mitostress and carnitine insufficiencies as critical determinants in aging and neurodegenerative disorders: role of hormesis and vitagenes
    Vittorio Calabrese
    Department of Chemistry, University of Catania, Viale Andrea Doria, 95100 Catania, Italy
    Neurochem Res 35:1880-915. 2010
    ....
  43. doi request reprint Vitagenes, cellular stress response, and acetylcarnitine: relevance to hormesis
    Vittorio Calabrese
    Department of Chemistry, University of Catania, Via Andrea Doria, Catania, Italy
    Biofactors 35:146-60. 2009
    ..c) 2009 International Union of Biochemistry and Molecular Biology, Inc...
  44. doi request reprint Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity
    Vittorio Calabrese
    Section of Biochemistry and Molecular Biology, Department of Chemistry, Faculty of Medicine, University of Catania, Viale Andrea Doria 6, 95100, Catania, Italy
    Neurochem Res 33:2444-71. 2008
    ..In this review the importance of vitagenes in the cellular stress response and the potential use of dietary antioxidants in the prevention and treatment of neurodegenerative disorders is discussed...
  45. ncbi request reprint Highlight Commentary on "Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis"
    Vittorio Calabrese
    Department of Chemistry, University of Catania, Viale Andrea Doria 6, Catania 95125, Italy
    Free Radic Biol Med 43:160-2. 2007
    ..Here my thoughts on the importance and impact of this paper are reported...
  46. doi request reprint Nitric oxide in cell survival: a janus molecule
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    Antioxid Redox Signal 11:2717-39. 2009
    ..The significance of NO in redox signaling and modulation of the adaptive cellular stress responses and its exciting future perspectives also are discussed...
  47. ncbi request reprint Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Molecular Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    Nat Rev Neurosci 8:766-75. 2007
    ..In fact, physiological amounts of this gas are neuroprotective, whereas higher concentrations are clearly neurotoxic...
  48. doi request reprint Carnosinase levels in aging brain: redox state induction and cellular stress response
    Francesco Bellia
    Department of Chemical Sciences, University of Catania, Catania section, Catania, Italy
    Antioxid Redox Signal 11:2759-75. 2009
    ....
  49. doi request reprint Practical approaches to investigate redox regulation of heat shock protein expression and intracellular glutathione redox state
    Vittorio Calabrese
    Department of Chemistry, Clinical Biochemistry and Clinical Molecular Biology Chair, University of Catania, Italy
    Methods Enzymol 441:83-110. 2008
    ....
  50. doi request reprint Oxidative stress, redox homeostasis and cellular stress response in Ménière's disease: role of vitagenes
    Vittorio Calabrese
    Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    Neurochem Res 35:2208-17. 2010
    ....
  51. ncbi request reprint Nitric oxide synthase is present in the cerebrospinal fluid of patients with active multiple sclerosis and is associated with increases in cerebrospinal fluid protein nitrotyrosine and S-nitrosothiols and with changes in glutathione levels
    Vittorio Calabrese
    Biochemistry and Molecular Biology Section, Department of Chemistry, Faculty of Medicine, University of Catania, Catania, Italy
    J Neurosci Res 70:580-7. 2002
    ....
  52. ncbi request reprint Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases
    Vittorio Calabrese
    Department of Chemistry, Biochemistry and Mol Biology Section, Faculty of Medicine, University of Catania, Catania, Italy
    Front Biosci (Landmark Ed) 14:376-97. 2009
    ....
  53. ncbi request reprint Upregulation of neuronal nitric oxide synthase in in vitro stellate astrocytes and in vivo reactive astrocytes after electrically induced status epilepticus
    Maria Vincenza Catania
    Institute of Neurological Sciences, National Research Council, Section of Catania, Vl Regina Margherita 6, 95125 Catania, Italy
    Neurochem Res 28:607-15. 2003
    ..Thus, nNOS upregulation occurs in both in vitro stellate and in vivo reactive astrocytes, suggesting a possible involvement of glial nNOS in neurological diseases characterized by reactive gliosis...
  54. ncbi request reprint Friedreich's ataxia: from disease mechanisms to therapeutic interventions
    Raffaele Lodi
    Dipartimento di Medicina Clinica e Biotecnologia Applicata, Universita di Bologna, Bologna, Italy
    Antioxid Redox Signal 8:438-43. 2006
    ..Pilot studies have shown the potential effect of antioxidant therapy in this condition and provide a strong rationale for designing larger clinical randomized trials...
  55. ncbi request reprint Ferulic acid ethyl ester protects neurons against amyloid beta- peptide(1-42)-induced oxidative stress and neurotoxicity: relationship to antioxidant activity
    Rukhsana Sultana
    Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
    J Neurochem 92:749-58. 2005
    ..These findings suggest that FAEE could potentially be of importance for the treatment of AD and other oxidative stress-related diseases...
  56. ncbi request reprint Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress
    Giovanni Scapagnini
    Institute of Neurological Sciences, CNR, 95123 Catania, Italy
    Antioxid Redox Signal 6:811-8. 2004
    ..This study identifies a novel natural compound that could be used for therapeutic purposes as a potent inducer of HO-1 for the protection of brain cells against oxidative and neurodegenerative conditions...
  57. ncbi request reprint Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis
    H Fai Poon
    Department of Chemistry, University of Kentucky, Lexington KY 40506, USA
    Free Radic Biol Med 39:453-62. 2005
    ....
  58. ncbi request reprint Effects of apolipoprotein E on the human immunodeficiency virus protein Tat in neuronal cultures and synaptosomes
    Chava B Pocernich
    Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506, USA
    J Neurosci Res 77:532-9. 2004
    ..We show that the antioxidant properties of apoE3 greatly outweigh the competition for clearance in deterring Tat-induced oxidative stress...
  59. ncbi request reprint Antisense directed at the Abeta region of APP decreases brain oxidative markers in aged senescence accelerated mice
    H Fai Poon
    Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington 40506 0055, USA
    Brain Res 1018:86-96. 2004
    ..Therefore, we conclude that Abeta may contribute to the oxidative stress found in aged SAMP8 mice that have learning and memory impairments. These results are discussed in reference to AD...
  60. ncbi request reprint Free radicals and brain aging
    H Fai Poon
    Department of Chemistry, Center of Membrane Sciences, University of Kentucky, Lexington 40506, USA
    Clin Geriatr Med 20:329-59. 2004
    ..We propose that free radicals are critical to cell damage in aged brain and endogenous, and that exogenous antioxidants, therefore, may play effective roles in therapeutic strategies for age-related neurodegenerative disorders...
  61. ncbi request reprint Free radicals: key to brain aging and heme oxygenase as a cellular response to oxidative stress
    H Fai Poon
    Department of Chemistry, Center of Membrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington 40506 0055, USA
    J Gerontol A Biol Sci Med Sci 59:478-93. 2004
    ..Therefore, this review supports the proposition that free radicals are, indeed, a key to brain aging...
  62. ncbi request reprint Elevation of mitochondrial glutathione by gamma-glutamylcysteine ethyl ester protects mitochondria against peroxynitrite-induced oxidative stress
    Jennifer Drake
    Department of Chemistry and Center of Membrane Sciences, University of Kentucky, Lexington, Kentucky 40506, USA
    J Neurosci Res 74:917-27. 2003
    ....
  63. ncbi request reprint Regional rat brain distribution of heme oxygenase-1 and manganese superoxide dismutase mRNA: relevance of redox homeostasis in the aging processes
    Claudia Colombrita
    Blanchette Rockefeller Neurosciences Institute, West Virginia University, Rockville, Maryland 20850, USA
    Exp Biol Med (Maywood) 228:517-24. 2003
    ..These regional age-dependent differences may help to explain the increased susceptibility to oxidative damage in these two brain areas during aging...
  64. ncbi request reprint Gene expression profiles of heme oxygenase isoforms in the rat brain
    Giovanni Scapagnini
    Blanchette Rockefeller Neurosciences Institute, West Virginia University at Johns Hopkins University, Rockville, MD 20850 3332, USA
    Brain Res 954:51-9. 2002
    ..HO-3 mRNA was expressed mainly in hippocampus, cerebellum and cortex. The initial elucidation of HO isoforms distribution should facilitate further research on their pathophysiological role in the nervous system...
  65. ncbi request reprint Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis
    Marzia Perluigi
    Department of Biochemical Sciences, University of Rome La Sapienza, Rome 00185, Italy
    Free Radic Biol Med 38:960-8. 2005
    ..These results support the role of oxidative stress as a major mechanism in the pathogenesis of ALS. Structural alteration and activity decline of functional proteins may consistently contribute to the neurodegeneration process in ALS...
  66. ncbi request reprint Mitochondrial associated metabolic proteins are selectively oxidized in A30P alpha-synuclein transgenic mice--a model of familial Parkinson's disease
    H Fai Poon
    Department of Chemistry, University of Kentucky, Lexington, KY 40506 0055, USA
    Neurobiol Dis 18:492-8. 2005
    ..Our findings suggest that proteins associated with impaired energy metabolism and mitochondria are particularly prone to oxidative stress associated with A30P-mutant alpha-synuclein...
  67. doi request reprint Bilirubin as an endogenous modulator of neurotrophin redox signaling
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Roma, Italy
    J Neurosci Res 86:2235-49. 2008
    ..Taken together, these observations indicate an important action of bilirubin on redox signaling by neurotrophins, with either inhibitory or agonistic effects based on growth factor availability...
  68. ncbi request reprint Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by L-acetylcarnitine: insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative stres
    H Fai Poon
    Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506 0055, USA
    Antioxid Redox Signal 8:381-94. 2006
    ..Moreover, those proteins that are reduced in oxidation status were identified in aged brains from rats treated in vivo with LAC. The findings are discussed in reference to brain aging and age-related cognitive impairment...
  69. ncbi request reprint Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Front Biosci 12:1107-23. 2007
    ..Food supplementation with curcumin and ferulic acid is considered a nutritional approach to reduce oxidative damage and amyloid pathology in Alzheimer disease...
  70. ncbi request reprint In vivo protective effects of ferulic acid ethyl ester against amyloid-beta peptide 1-42-induced oxidative stress
    Marzia Perluigi
    Department of Biochemical Sciences, University of Rome La Sapienza, Rome, Italy
    J Neurosci Res 84:418-26. 2006
    ..These results are discussed with potential therapeutic implications of FAEE, a brain accessible, multifunctional antioxidant compound, for AD involving modulation of free radicals generated by Abeta...
  71. ncbi request reprint Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease
    Hafiz Mohmmad Abdul
    Department of Chemistry, Center for Membrane Sciences, University of Kentucky, Lexington, 40506, USA
    J Neurosci Res 84:398-408. 2006
    ..This evidence supports the pharmacological potential of acetyl carnitine in the management of Abeta(1-42)-induced oxidative stress and neurotoxicity. Therefore, ALCAR may be useful as a possible therapeutic strategy for patients with AD...
  72. ncbi request reprint In vivo protection of synaptosomes by ferulic acid ethyl ester (FAEE) from oxidative stress mediated by 2,2-azobis(2-amidino-propane)dihydrochloride (AAPH) or Fe(2+)/H(2)O(2): insight into mechanisms of neuroprotection and relevance to oxidative stress-re
    Gururaj Joshi
    Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA
    Neurochem Int 48:318-27. 2006
    ..These results are discussed with reference to potential use of this lipophilic antioxidant phenolic compound in the treatment of oxidative stress-related neurodegenerative disorders...
  73. ncbi request reprint Proteomics analysis provides insight into caloric restriction mediated oxidation and expression of brain proteins associated with age-related impaired cellular processes: Mitochondrial dysfunction, glutamate dysregulation and impaired protein synthesis
    H Fai Poon
    Department of Chemistry, University of Kentucky, Center of Membrane Sciences, Sanders Brown Center on Aging, 255 Bowman Hall, Lexington, KY 40506 0055, USA
    Neurobiol Aging 27:1020-34. 2006
    ..This study provides valuable insights into the mechanisms of the beneficial factors on brain aging by CR...
  74. ncbi request reprint Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death
    Andriani Athanasiou
    School of Biomedical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Biochem Biophys Res Commun 364:131-7. 2007
    ..These data demonstrate that AEA, THC, and HU 210 are all able to cause changes in integrated mitochondrial function, directly, in the absence of cannabinoid receptors...
  75. ncbi request reprint Natural antioxidants in Alzheimer's disease
    Cesare Mancuso
    Catholic University School of Medicine, Institute of Pharmacology, Largo F Vito, 00168 Roma, Italy
    Expert Opin Investig Drugs 16:1921-31. 2007
    ..The association with new drug delivery systems may be desirable and useful for the therapeutic use of antioxidants in human neurodegenerative diseases...
  76. ncbi request reprint Proteomic analysis of protein expression and oxidative modification in r6/2 transgenic mice: a model of Huntington disease
    Marzia Perluigi
    Department of Biochemical Sciences, University of Rome La Sapienza, 00185 Rome, Italy
    Mol Cell Proteomics 4:1849-61. 2005
    ....
  77. ncbi request reprint Vitamin E and neurodegenerative disorders associated with oxidative stress
    D Allan Butterfield
    Department of Chemistry, Center of Membrane Sciences, and Sanders Brown Center on Aging, University of Kentucky, Lexington 40506, USA
    Nutr Neurosci 5:229-39. 2002
    ..This review presents some of the chemistry of vitamin E as an antioxidant and summarizes studies in which vitamin E has been employed in these disorders and models thereof...
  78. ncbi request reprint Bilirubin: an endogenous scavenger of nitric oxide and reactive nitrogen species
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Redox Rep 11:207-13. 2006
    ..The aim of this paper is to give an overview of the interaction between bilirubin and nitric oxide/reactive nitrogen species; furthermore, the possible pathophysiological and clinical relevance of this interaction will be discussed...
  79. ncbi request reprint Antiaging medicine: antioxidants and aging
    Vittorio Calabrese
    Antioxid Redox Signal 8:362-4. 2006
  80. ncbi request reprint Heme oxygenase and cyclooxygenase in the central nervous system: a functional interplay
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    J Neurosci Res 84:1385-91. 2006
    ..The importance of the interaction between HO and COX in the regulation of physiologic brain functions, and its relevance to neuroprotective or neurodegenerative mechanisms are discussed...