Massimiliano Calabrese

Summary

Affiliation: University of Foggia
Country: Italy

Publications

  1. pmc Cortical Pathology in RRMS: Taking a Cue from Four Sisters
    Massimiliano Calabrese
    The Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padua, Via Giustiniani 5, 35128 Padoua, Italy
    Mult Scler Int 2012:760254. 2012
  2. doi request reprint No MRI evidence of cortical lesions in neuromyelitis optica
    Massimiliano Calabrese
    Advanced Neuroimaging Lab of The Multiple Sclerosis Centre of Veneto Region First Neurology Clinic, Department of Neurosciences, University Hospital of Padua, Italy
    Neurology 79:1671-6. 2012
  3. doi request reprint Low degree of cortical pathology is associated with benign course of multiple sclerosis
    Massimiliano Calabrese
    The Multiple Sclerosis Centre of the Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padova, Italy
    Mult Scler 19:904-11. 2013
  4. pmc Grey matter lesions in MS: from histology to clinical implications
    Massimiliano Calabrese
    The Multiple Sclerosis Center, Deptartment of Neurosciences, University Hospital of Padova, Padua, Italy
    Prion 7:20-7. 2013
  5. doi request reprint Cortical diffusion-tensor imaging abnormalities in multiple sclerosis: a 3-year longitudinal study
    Massimiliano Calabrese
    Department of Neurosciences, Multiple Sclerosis Centre of Veneto Region First Neurology Clinic, University Hospital of Padova, Via Giustiniani 5, 35128 Padua, Italy
    Radiology 261:891-8. 2011
  6. doi request reprint The association of intrathecal immunoglobulin synthesis and cortical lesions predicts disease activity in clinically isolated syndrome and early relapsing-remitting multiple sclerosis
    Massimiliano Calabrese
    Multiple Sclerosis Centre, Department of Neuroscience, University Hospital of Padova, Italy
    Mult Scler 18:174-80. 2012
  7. doi request reprint Gray matter pathology in MS: a 3-year longitudinal study in a pediatric population
    M Calabrese
    Multiple Sclerosis Centre of Veneto Region First Neurology Clinic, Department of Neurosciences, University Hospital of Padua, Italy
    AJNR Am J Neuroradiol 33:1507-11. 2012
  8. doi request reprint Cortical lesion load associates with progression of disability in multiple sclerosis
    Massimiliano Calabrese
    Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, University Hospital of Padova, Padova35128, Italy
    Brain 135:2952-61. 2012
  9. doi request reprint Effect of disease-modifying drugs on cortical lesions and atrophy in relapsing-remitting multiple sclerosis
    M Calabrese
    The Multiple Sclerosis Centre of the Veneto Region, Department of Neurology, University Hospital of Padova, Padova, Italy
    Mult Scler 18:418-24. 2012
  10. doi request reprint Magnetic resonance evidence of cerebellar cortical pathology in multiple sclerosis
    Massimiliano Calabrese
    Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padova, Via Giustiniani 3, 35128 Padua, Italy
    J Neurol Neurosurg Psychiatry 81:401-4. 2010

Collaborators

Detail Information

Publications42

  1. pmc Cortical Pathology in RRMS: Taking a Cue from Four Sisters
    Massimiliano Calabrese
    The Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padua, Via Giustiniani 5, 35128 Padoua, Italy
    Mult Scler Int 2012:760254. 2012
    ..This hypothesis should be further evaluated in a large number of multiplex MS families...
  2. doi request reprint No MRI evidence of cortical lesions in neuromyelitis optica
    Massimiliano Calabrese
    Advanced Neuroimaging Lab of The Multiple Sclerosis Centre of Veneto Region First Neurology Clinic, Department of Neurosciences, University Hospital of Padua, Italy
    Neurology 79:1671-6. 2012
    ..Although AQP4 is expressed in human cortex, recent histologic studies have failed to find any evidence of cortical demyelination in NMO...
  3. doi request reprint Low degree of cortical pathology is associated with benign course of multiple sclerosis
    Massimiliano Calabrese
    The Multiple Sclerosis Centre of the Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padova, Italy
    Mult Scler 19:904-11. 2013
    ..Although a more favorable course of multiple sclerosis is associated with a low degree of cortical pathology, only longitudinal studies could definitely confirm this association...
  4. pmc Grey matter lesions in MS: from histology to clinical implications
    Massimiliano Calabrese
    The Multiple Sclerosis Center, Deptartment of Neurosciences, University Hospital of Padova, Padua, Italy
    Prion 7:20-7. 2013
    ..This review provides a summary of the main histopathological and MRI findings of cortical lesions in MS and discusses their possible clinical implications...
  5. doi request reprint Cortical diffusion-tensor imaging abnormalities in multiple sclerosis: a 3-year longitudinal study
    Massimiliano Calabrese
    Department of Neurosciences, Multiple Sclerosis Centre of Veneto Region First Neurology Clinic, University Hospital of Padova, Via Giustiniani 5, 35128 Padua, Italy
    Radiology 261:891-8. 2011
    ..To evaluate whether diffusion-tensor imaging can be combined with double inversion recovery to improve the detection of structural changes occurring in the cortex of patients with multiple sclerosis (MS)...
  6. doi request reprint The association of intrathecal immunoglobulin synthesis and cortical lesions predicts disease activity in clinically isolated syndrome and early relapsing-remitting multiple sclerosis
    Massimiliano Calabrese
    Multiple Sclerosis Centre, Department of Neuroscience, University Hospital of Padova, Italy
    Mult Scler 18:174-80. 2012
    ..The intrathecal production of immunoglobulin (Ig) is a major biological feature of multiple sclerosis (MS), and immunopathological studies have suggested a primary role of the humoral immune response in causing irreversible brain damage...
  7. doi request reprint Gray matter pathology in MS: a 3-year longitudinal study in a pediatric population
    M Calabrese
    Multiple Sclerosis Centre of Veneto Region First Neurology Clinic, Department of Neurosciences, University Hospital of Padua, Italy
    AJNR Am J Neuroradiol 33:1507-11. 2012
    ..Thus, we planned a longitudinal study aimed at analyzing and comparing cortical pathology in pediatric and adult MS patients at clinical onset...
  8. doi request reprint Cortical lesion load associates with progression of disability in multiple sclerosis
    Massimiliano Calabrese
    Department of Neurosciences, The Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, University Hospital of Padova, Padova35128, Italy
    Brain 135:2952-61. 2012
    ....
  9. doi request reprint Effect of disease-modifying drugs on cortical lesions and atrophy in relapsing-remitting multiple sclerosis
    M Calabrese
    The Multiple Sclerosis Centre of the Veneto Region, Department of Neurology, University Hospital of Padova, Padova, Italy
    Mult Scler 18:418-24. 2012
    ..To measure the effects of disease-modifying drugs (DMDs) on the development of cortical lesions (CL) and cortical atrophy in patients with relapsing-remitting multiple sclerosis (RRMS)...
  10. doi request reprint Magnetic resonance evidence of cerebellar cortical pathology in multiple sclerosis
    Massimiliano Calabrese
    Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padova, Via Giustiniani 3, 35128 Padua, Italy
    J Neurol Neurosurg Psychiatry 81:401-4. 2010
    ..Although neuropathological observations suggest that cerebellar cortex is a major site of demyelination in multiple sclerosis (MS), only a few MRI studies on cerebellar cortical pathology in MS are available...
  11. doi request reprint Magnetic resonance evidence of cortical onset of multiple sclerosis
    M Calabrese
    Department of Neurosciences, Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, University Hospital of Padua, Padua, Italy
    Mult Scler 15:933-41. 2009
    ..Despite clinical symptoms and signs of central nervous system dysfunction, conventional magnetic resonance imaging (MRI) of the brain and spinal cord may appear normal in multiple sclerosis (MS) at clinical onset...
  12. doi request reprint Basal ganglia and frontal/parietal cortical atrophy is associated with fatigue in relapsing-remitting multiple sclerosis
    Massimiliano Calabrese
    The Multiple Sclerosis Centre of Veneto Region First Neurology Clinic, Department of Neurosciences, University Hospital of Padua, Italy
    Mult Scler 16:1220-8. 2010
    ..Fatigue is one of the most frequent symptoms suffered by patients affected by multiple sclerosis. The patho-physiological basis of multiple sclerosis-related fatigue remains to be elucidated...
  13. doi request reprint Cortical lesions in multiple sclerosis
    Massimiliano Calabrese
    The Multiple Sclerosis Center, Department of Neuroscience, University of Padova, Via Giustiniani 3, 35128 Padova, Italy
    Nat Rev Neurol 6:438-44. 2010
    ..This Review provides a summary of the main histopathological and MRI findings with regard to cortical lesions in MS, and indicates that increasing our understanding of cortical lesions has increased our knowledge of MS pathobiology...
  14. doi request reprint The predictive value of gray matter atrophy in clinically isolated syndromes
    M Calabrese
    Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padova, Via Giustiniani 5, 35128 Padova, Italy
    Neurology 77:257-63. 2011
    ..Methodologic and clinical constraints may take account for literature discrepancies...
  15. ncbi request reprint The puzzle of multiple sclerosis: gray matter finds its place
    Massimiliano Calabrese
    Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padova, Via Giustiniani 5, 35128 Padova, Italy
    Expert Rev Neurother 11:1565-8. 2011
    ..Another preliminary exciting step has therefore been taken toward the comprehension of the MS puzzle...
  16. doi request reprint Extensive cortical inflammation is associated with epilepsy in multiple sclerosis
    Massimiliano Calabrese
    The Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Dept of Neurosciences, University Hospital of Padova, Via Giustiniani 5, 35128 Padova, Italy
    J Neurol 255:581-6. 2008
    ..We applied the double inversion recovery (DIR) sequence in relapsing remitting MS (RRMS) patients with or without epileptic seizures in order to clarify the relationship between ICLs and epilepsy in MS in vivo...
  17. ncbi request reprint Detection of cortical inflammatory lesions by double inversion recovery magnetic resonance imaging in patients with multiple sclerosis
    Massimiliano Calabrese
    Multiple Sclerosis Centre of the Veneto Region First Neurology Clinic, University Hospital of Padova, Via Giustiniani 5, 35128 Padova, Italy
    Arch Neurol 64:1416-22. 2007
    ..A significant inflammatory pathologic disorder in the cortex of patients with multiple sclerosis (MS) has been demonstrated by ex vivo studies...
  18. ncbi request reprint Cortical atrophy is relevant in multiple sclerosis at clinical onset
    Massimiliano Calabrese
    The Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Dept of Neurosciences, University Hospital of Padova, Via Giustiniani 5, 35128 Padova, Italy
    J Neurol 254:1212-20. 2007
    ....
  19. doi request reprint Cortical pathology in multiple sclerosis patients with epilepsy: a 3 year longitudinal study
    M Calabrese
    Multiple Sclerosis Centre, First Neurology Clinic, University of Padova, Via Giustiniani 5, Padova 35128, Italy
    J Neurol Neurosurg Psychiatry 83:49-54. 2012
    ..The cause of epilepsy in multiple sclerosis (MS) has not yet been elucidated. The relevance of cortical pathology (cortical lesions and thickness) in MS patients with and without epilepsy was evaluated in a longitudinal study...
  20. doi request reprint Widespread cortical thinning characterizes patients with MS with mild cognitive impairment
    M Calabrese
    Department of Neurosciences, University Hospital of Padova, Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, 35128 Padova, Italy
    Neurology 74:321-8. 2010
    ..Although cognitive dysfunction affects a relevant portion of patients with multiple sclerosis (MS), its pathologic substrate has not been clarified and it does not seem entirely explained by white matter changes...
  21. doi request reprint Cortical lesions and atrophy associated with cognitive impairment in relapsing-remitting multiple sclerosis
    Massimiliano Calabrese
    Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padua
    Arch Neurol 66:1144-50. 2009
    ..Double inversion recovery sequences allow cortical lesions (CLs) to be detected in the brain of patients with MS. Modern postprocessing techniques allow cortical atrophy to be assessed reliably...
  22. doi request reprint A 3-year magnetic resonance imaging study of cortical lesions in relapse-onset multiple sclerosis
    Massimiliano Calabrese
    Multiple Sclerosis Center of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padua, Padua, Italy
    Ann Neurol 67:376-83. 2010
    ....
  23. doi request reprint The changing clinical course of multiple sclerosis: a matter of gray matter
    Massimiliano Calabrese
    First Neurological Clinic, Department of Neurosciences, University Hospital of Padua, Padua, Italy Neuroimaging Unit, Euganea Medica, Padua, Italy
    Ann Neurol 74:76-83. 2013
    ..We specifically designed a prospective 5-year longitudinal study aimed at assessing demographic, clinical, and magnetic resonance imaging (MRI) parameters that could predict the changing clinical course of MS...
  24. doi request reprint Morphology and evolution of cortical lesions in multiple sclerosis. A longitudinal MRI study
    Massimiliano Calabrese
    The Multiple Sclerosis Centre of Veneto Region First Neurology Clinic, Department of Neurosciences, University Hospital of Padua, Italy
    Neuroimage 42:1324-8. 2008
    ..The short-term rate of CLs accumulation does not seem to vary according to the clinical stage of MS...
  25. pmc Heterogeneity of cortical lesions in multiple sclerosis: an MRI perfusion study
    Denis Peruzzo
    Department of Information Engineering, University of Padova, Padova, Italy
    J Cereb Blood Flow Metab 33:457-63. 2013
    ..These findings show that perfusion is altered in cortical lesions and that DSC-MRI can be a useful tool to investigate more deeply the evolution of cortical lesions in multiple sclerosis...
  26. doi request reprint No evidence of JC virus reactivation in natalizumab treated multiple sclerosis patients: an 18 month follow-up study
    Luciano Rinaldi
    Department of Neuroscience, Multiple Sclerosis Centre, First Clinic of Neurology, University Hospital of Padova, Padova, Italy
    J Neurol Neurosurg Psychiatry 81:1345-50. 2010
    ..This study evaluated whether JCV reactivation occurred in the urine and/or plasma in 42 MS patients treated with natalizumab over 18 months, and followed by a thorough monitoring programme...
  27. ncbi request reprint Mitoxantrone versus cyclophosphamide in secondary-progressive multiple sclerosis: a comparative study
    Paola Perini
    Multiple Sclerosis Centre of Veneto Region First Neurology Clinic, University Hospital of Padova, Via Giustiniani 5, 35128 Padova, Italy
    J Neurol 253:1034-40. 2006
    ..The safety profiles of both drugs were acceptable; however, the Cy-based therapy protocol was significantly less expensive. We conclude that Cy should be considered as a therapeutic option in rapidly deteriorating SPMS patients...
  28. doi request reprint Cyclophosphamide-based combination therapies for autoimmunity
    Paola Perini
    Multiple Sclerosis Centre Veneto Region, Department of Neuroscience, University Hospital, Via Giustiniani 5, 35128, Padova, Italy
    Neurol Sci 29:S233-4. 2008
    ..The association of Cyc with other immunomodulatory drugs or monoclonal antibodies is currently being investigated in clinical trials aimed at treating severe forms of autoimmune diseases...
  29. doi request reprint Investigation of the neural correlates underlying action observation in multiple sclerosis patients
    Andrea C Pierno
    Department of General Psychology, University of Padova, Via Venezia 8, 35131, Padova, Italy
    Exp Neurol 217:252-7. 2009
    ....
  30. doi request reprint Cortical pathology and cognitive impairment in multiple sclerosis
    Massimiliano Calabrese
    Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padova, Padova, 35128, Italy
    Expert Rev Neurother 11:425-32. 2011
    ..Therefore, MRI evaluation of cortical pathology should be included in the routine examination of MS patients, especially those with initial signs/symptoms of cognitive dysfunctions...
  31. ncbi request reprint Longitudinal analysis of immune cell phenotypes in early stage multiple sclerosis: distinctive patterns characterize MRI-active patients
    Luciano Rinaldi
    Research and Innovation R and I Company, Padova, Italy
    Brain 129:1993-2007. 2006
    ....
  32. doi request reprint Severe relapses after the first infusion of natalizumab in active relapsing-remitting multiple sclerosis
    Francesca Rinaldi
    Multiple Sclerosis Centre of Veneto Region of Italy, Department of Neuroscience, University Hospital of Padova, Padova, Italy
    Mult Scler 15:1359-62. 2009
    ..We suggest that relapsing-remitting MS patients having had a recent relapse should be treated with natalizumab only after achieving complete clinical and radiological remission...
  33. ncbi request reprint The safety profile of cyclophosphamide in multiple sclerosis therapy
    Paola Perini
    Multiple Sclerosis Centre Veneto Region, First Neurology Clinic, University Hospital, Padova, Italy
    Expert Opin Drug Saf 6:183-90. 2007
    ..Short course (6-12 months) of Cyc therapy can precede the initiation of immunomodulatory treatment in selected patients with an aggressive MS onset...
  34. ncbi request reprint Multiple sclerosis and autoimmune diseases: epidemiology and HLA-DR association in North-east Italy
    Alice Laroni
    Multiple Sclerosis Centre of the Veneto, Region, First Neurology Clinic Dept of Neurosciences, University of Padova, Via Giustiniani 5, 35128, Padova, Italy
    J Neurol 253:636-9. 2006
    ..01). We conclude that the risk of autoimmune disease is higher in first-degree relatives of MS patients and that disease association and HLA-DR expression in North-east Italy differs from other geographic regions of Europe...
  35. doi request reprint No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset
    Claudio Baracchini
    First Neurology Clinic, University Hospital, Padova, Italy
    Ann Neurol 69:90-9. 2011
    ..We investigated this hypothesis by studying the occurrence of CCSVI in clinically isolated syndromes (CISs) suggestive of MS...
  36. ncbi request reprint The clinical impact of interferon beta antibodies in relapsing-remitting MS
    Paola Perini
    Multiple Sclerosis Centre First Neurology Clinic, Dept of Neurological and Psychiatrical Sciences, University of Padova, Via Giustiniani, 5, 35128 Padova, Italy
    J Neurol 251:305-9. 2004
    ..These findings demonstrate that high titers of both BAbs and NAbs reduce the clinical efficacy of IFNbeta in patients with RRMS, which is important for the long-term efficacy of these drugs...
  37. pmc Intrathecal IgM production at clinical onset correlates with a more severe disease course in multiple sclerosis
    P Perini
    Multiple Sclerosis Centre of the Veneto Region, Department of Neurosciences, University Hospital of Padova, Padova, Italy
    J Neurol Neurosurg Psychiatry 77:953-5. 2006
    ..If these findings are confirmed in patients with multiple sclerosis in a larger series, a helpful biological marker for selecting patients for immunomodulatory treatments will be available to neurologists...
  38. doi request reprint Imaging distribution and frequency of cortical lesions in patients with multiple sclerosis
    M Calabrese
    The Multiple Sclerosis Centre of Veneto Region, First Neurology Clinic, Department of Neurosciences, University Hospital of Padova, Italy
    Neurology 75:1234-40. 2010
    ..MRI-based lesion probability maps (LPMs) may partially overcome this lack of sensitivity and provide unique information on the spatial distribution and frequency of CLs in MS...
  39. doi request reprint Evidence for relative cortical sparing in benign multiple sclerosis: a longitudinal magnetic resonance imaging study
    M Calabrese
    The Multiple Sclerosis Centre of Veneto Region First Neurology Clinic, Department of Neurosciences, University Hospital of Padua, Padua, Italy
    Mult Scler 15:36-41. 2009
    ..Using double inversion recovery (DIR) MRI, cortical lesions can be seen in the brain of patients with multiple sclerosis (MS). The burden of such lesions seems to be well correlated with the severity of MS-related disability...
  40. ncbi request reprint Increasing frequency of multiple sclerosis in Padova, Italy: a 30 year epidemiological survey
    F Ranzato
    Department of Neurological and Psychiatric Sciences, First Neurology Clinic, University of Padova, Via Giustiniani, Padova, Italy
    Mult Scler 9:387-92. 2003
    ..To determine the incidence and prevalence rates of multiple sclerosis (MS) and their temporal profiles over the last 30 years in the province of Padova (northeast Italy)...
  41. doi request reprint Clinical and diagnostic aspects of multiple sclerosis and acute monophasic encephalomyelitis in pediatric patients: a single centre prospective study
    M Atzori
    Multiple Sclerosis Centre of the Veneto Region, First Neurology Clinic, Department of Pediatrics, University of Padova, and Department of Neuroscience, University Hospital of Padova, Padova, Italy
    Mult Scler 15:363-70. 2009
    ....
  42. doi request reprint Cyclophosphamide as second-line therapy in multiple sclerosis: benefits and risks
    Luciano Rinaldi
    Department of Neuroscience, Multiple Sclerosis Centre, University Hospital of Padova, Padova, Italy
    Neurol Sci 30:S171-3. 2009
    ..As second-line therapy, Cy can be used in non-responders to IFN-beta or glatiramer acetate. As induction therapy, a short course (6-12 months) of Cy can precede immunomodulatory drugs in selected patients with an aggressive MS onset...