Ivana Cacciatore

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. doi request reprint Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties
    Ivana Cacciatore
    Department of Pharmacy, University G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy Electronic address
    Eur J Med Chem 108:553-63. 2016
  2. pmc A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells
    Ivana Cacciatore
    Dipartimento di Farmacia, Universita degli Studi G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    Pharmaceuticals (Basel) 6:54-69. 2013
  3. doi request reprint A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation
    Ivana Cacciatore
    Department of Pharmacy, University G D Annunzio, Via dei Vestini 31, 66100 Chieti Italy
    ChemMedChem 8:1818-29. 2013
  4. doi request reprint (R)-α-lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities
    Ivana Cacciatore
    Dipartimento di Farmacia, Universita degli Studi G D Annunzio, Via dei Vestini 31, 66100 Chieti Italy
    ChemMedChem 7:2021-9. 2012
  5. pmc Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems
    Ivana Cacciatore
    Department of Drug Sciences, Faculty of Pharmacy, G D Annunzio University, Chieti, Italy
    Oxid Med Cell Longev 2012:240146. 2012
  6. ncbi request reprint GPE and GPE analogues as promising neuroprotective agents
    I Cacciatore
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti Scalo CH, Italy
    Mini Rev Med Chem 12:13-23. 2012
  7. doi request reprint New L-dopa codrugs as potential antiparkinson agents
    Piera Sozio
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti, Italy
    Arch Pharm (Weinheim) 341:412-7. 2008
  8. doi request reprint CNS delivery of L-dopa by a new hybrid glutathione-methionine peptidomimetic prodrug
    Francesco Pinnen
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66100, Chieti, Italy
    Amino Acids 42:261-9. 2012
  9. doi request reprint Memantine-sulfur containing antioxidant conjugates as potential prodrugs to improve the treatment of Alzheimer's disease
    Piera Sozio
    Dipartimento di Farmacia, Universita G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    Eur J Pharm Sci 49:187-98. 2013
  10. ncbi request reprint Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists
    Antonio Di Stefano
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Med Chem 48:2646-54. 2005

Collaborators

Detail Information

Publications32

  1. doi request reprint Development of glycine-α-methyl-proline-containing tripeptides with neuroprotective properties
    Ivana Cacciatore
    Department of Pharmacy, University G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy Electronic address
    Eur J Med Chem 108:553-63. 2016
    ..Therefore, GP(Me)H could be a lead compound for further development of peptidomimetics able to contrast neuroinflammatory processes. ..
  2. pmc A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells
    Ivana Cacciatore
    Dipartimento di Farmacia, Universita degli Studi G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    Pharmaceuticals (Basel) 6:54-69. 2013
    ..In particular, it showed potent neuroprotective effects against 6-OHDA in RA/PMA differentiated cells at all the tested concentrations. ..
  3. doi request reprint A glutathione derivative with chelating and in vitro neuroprotective activities: synthesis, physicochemical properties, and biological evaluation
    Ivana Cacciatore
    Department of Pharmacy, University G D Annunzio, Via dei Vestini 31, 66100 Chieti Italy
    ChemMedChem 8:1818-29. 2013
    ..Together, these findings suggest that GS(HQ)H could be a potential neuroprotective agent for the treatment of neurodegenerative diseases in which a lack of metal homeostasis has been reported as a key factor. ..
  4. doi request reprint (R)-α-lipoyl-glycyl-L-prolyl-L-glutamyl dimethyl ester codrug as a multifunctional agent with potential neuroprotective activities
    Ivana Cacciatore
    Dipartimento di Farmacia, Universita degli Studi G D Annunzio, Via dei Vestini 31, 66100 Chieti Italy
    ChemMedChem 7:2021-9. 2012
    ..51) and a pH-dependent permeability profile. Furthermore, LA-GPE was demonstrated to be significantly neuroprotective and to act as an antioxidant against H2O2- and 6-OHDA-induced neurotoxicity in SH-SY5Y cells...
  5. pmc Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems
    Ivana Cacciatore
    Department of Drug Sciences, Faculty of Pharmacy, G D Annunzio University, Chieti, Italy
    Oxid Med Cell Longev 2012:240146. 2012
    ..Here, we discuss the beneficial properties of these approaches and their potential implications for the future treatment of patients suffering from neurodegenerative diseases, and more specifically from PD and AD...
  6. ncbi request reprint GPE and GPE analogues as promising neuroprotective agents
    I Cacciatore
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti Scalo CH, Italy
    Mini Rev Med Chem 12:13-23. 2012
    ....
  7. doi request reprint New L-dopa codrugs as potential antiparkinson agents
    Piera Sozio
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti, Italy
    Arch Pharm (Weinheim) 341:412-7. 2008
    ..The results suggest that, though our codrugs are devoid of significant antioxidant activity, they are able to induce sustained delivery of DA in rat striatum and can improve LD and DA release in the brain...
  8. doi request reprint CNS delivery of L-dopa by a new hybrid glutathione-methionine peptidomimetic prodrug
    Francesco Pinnen
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66100, Chieti, Italy
    Amino Acids 42:261-9. 2012
    ..These results are of significance for prospective therapeutic application of prodrug 1 in pathological events associated with free radical damage and decreasing DA concentration in the brain...
  9. doi request reprint Memantine-sulfur containing antioxidant conjugates as potential prodrugs to improve the treatment of Alzheimer's disease
    Piera Sozio
    Dipartimento di Farmacia, Universita G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    Eur J Pharm Sci 49:187-98. 2013
    ....
  10. ncbi request reprint Preparation and pharmacological characterization of trans-2-amino-5(6)-fluoro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as D2-like dopamine receptor agonists
    Antonio Di Stefano
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Med Chem 48:2646-54. 2005
    ..The selective D(2)-like agonism of compounds 20 and 5e was proved by their effects on basal striatal adenylyl cyclase activity...
  11. doi request reprint Codrugs linking L-dopa and sulfur-containing antioxidants: new pharmacological tools against Parkinson's disease
    Francesco Pinnen
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Med Chem 52:559-63. 2009
    ..After intracerebroventricular injection of codrug 4, the levels of DA in the striatum were higher than those in LD-treated groups, indicating that this compound has a longer half-life in brain than LD...
  12. doi request reprint Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease
    Francesco Pinnen
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti, Italy
    Arch Pharm (Weinheim) 344:139-48. 2011
    ..c.v.) infusion of Aβ(1-40) in rats, and thus that codrug 1 could prove useful as a tool for controlling AD induced cerebral amyloid deposits and behavioral deterioration...
  13. ncbi request reprint Effect of MRJF4 on C6 Glioma Cells Proliferation and Migration
    Stephaniè Pacella
    Department of Pharmacy, University G D Annunzio, Via dei Vestini, 66100 Chieti, Italy
    Cent Nerv Syst Agents Med Chem . 2016
    ..In particular, changes in Nf-kB signaling pathway, activity of nitric oxide synthases (NOS), metalloproteinases (MMPs), and membrane adhesion proteins were investigated...
  14. ncbi request reprint Synthesis and study of L-dopa-glutathione codrugs as new anti-Parkinson agents with free radical scavenging properties
    Francesco Pinnen
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Med Chem 50:2506-15. 2007
    ....
  15. ncbi request reprint Synthesis and antioxidant properties of novel memantine derivatives
    Ivana Cacciatore
    Department of Pharmacy, University G d Annunzio of Chieti Pescara, Via dei Vestini 31, Chieti Scalo CH, Italy
    Cent Nerv Syst Agents Med Chem . 2016
    ....
  16. doi request reprint Synthesis of a novel cyclic prodrug of S-allyl-glutathione able to attenuate LPS-induced ROS production through the inhibition of MAPK pathways in U937 cells
    Antonia Patruno
    Department of Pharmacy and Department of Medicine and Aging Science, University G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    Mol Pharm 12:66-74. 2015
    ..Biological studies revealed that CP11 is able to modulate inflammation mediated by LPS in U937 cells preventing the increase of ROS intracellular levels through interaction with the MAPK pathway. ..
  17. doi request reprint New flurbiprofen derivatives: synthesis, membrane affinity and evaluation of in vitro effect on β-amyloid levels
    Piera Sozio
    Department of Pharmacy, G D Annunzio University, Via dei Vestini 31, Chieti 66100, Italy
    Molecules 18:10747-67. 2013
    ..Interestingly, the investigated molecules demonstrated to reduce Aβ 42 levels without affecting the amyloid precursor protein APP level in a clear concentrations-dependent manner...
  18. ncbi request reprint Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione
    Ivana Cacciatore
    Dipartimento di Scienze del Farmaco, Universita degli Studi G D Annunzio, 66013 Chieti, Italy
    J Pept Sci 10:109-14. 2004
    ..The fully deprotected glutathione analogue containing the aminomethylene unit as transition state isostere of the gamma-Glu-Cys peptide bond was synthesized for the first time and characterized in both the reduced and oxidized forms...
  19. doi request reprint Solid lipid nanoparticles loaded with lipoyl-memantine codrug: preparation and characterization
    Sara Laserra
    Department of Pharmacy, G D Annunzio University of Chieti Pescara, Via dei Vestini 31, 66100 Chieti, Italy
    Int J Pharm 485:183-91. 2015
    ....
  20. doi request reprint Haloperidol metabolite II prodrug: asymmetric synthesis and biological evaluation on rat C6 glioma cells
    Piera Sozio
    Dipartimento di Farmacia, Università degli Studi di Chieti Gabriele D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    Eur J Med Chem 90:1-9. 2015
    ....
  21. ncbi request reprint Synthesis and biological evaluation of the disulfide form of the glutathione analogue gamma-(L-glutamyl)-L-cysteinyl-L-aspartyl-L-cysteine
    Ivana Cacciatore
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, Chieti 66100, Italy
    Bioorg Chem 31:109-21. 2003
    ..The activity of (4) with gamma-glutamyl-transferase and glutathione reductase has been evaluated and compared with those of the two conformationally restricted glutathione analogues (2) and (3) previously reported...
  22. pmc Carvacrol codrugs: a new approach in the antimicrobial plan
    Ivana Cacciatore
    Department of Pharmacy, University G D Annunzio Chieti Pescara, Chieti, Italy
    PLoS ONE 10:e0120937. 2015
    ....
  23. ncbi request reprint Structure-activity relationships of biphalin analogs and their biological evaluation on opioid receptors
    Federica Feliciani
    Dipartimento di Farmacia, Università di Chieti Pescara G d Annunzio, Chieti, Italy
    Mini Rev Med Chem 13:11-33. 2013
    ....
  24. ncbi request reprint Delivery methods of camptothecin and its hydrosoluble analogue irinotecan for treatment of colorectal cancer
    Adriano Mollica
    Dipartimento di Scienze del Farmaco, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    Curr Drug Deliv 9:122-31. 2012
    ..The aim of this work is to review the state of the art of camptothecin and its derivative irinotecan's delivery methods...
  25. doi request reprint Prodrug approach for increasing cellular glutathione levels
    Ivana Cacciatore
    Department of Drug Sciences, School of Pharmacy, G D Annunzio University, Via dei Vestini 31, 66100 Chieti, Italy
    Molecules 15:1242-64. 2010
    ..This review discusses different strategies for increasing GSH levels by supplying reversible bioconjugates able to cross the cellular membrane more easily than GSH and to provide a source of thiols for GSH synthesis...
  26. doi request reprint Solid lipid nanoparticles as a drug delivery system for the treatment of neurodegenerative diseases
    Ivana Cacciatore
    a Department of Pharmacy, University G D Annunzio Chieti Pescara, Chieti, Italy
    Expert Opin Drug Deliv 13:1121-31. 2016
    ....
  27. doi request reprint New bifunctional antioxidant/σ1 agonist ligands: Preliminary chemico-physical and biological evaluation
    Emanuela Arena
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Bioorg Med Chem 24:3149-56. 2016
    ..In particular, our data suggest that new very selective compounds 7 and 12 could be promising tools to investigate the disorders in which σ1 receptor dysfunction and oxidative stress are contemporarily involved. ..
  28. pmc Novel NSAID-Derived Drugs for the Potential Treatment of Alzheimer's Disease
    Ivana Cacciatore
    Department of Pharmacy, University G d Annunzio of Chieti Pescara, Via dei Vestini 31, 66100 Chieti Scalo CH, Italy
    Int J Mol Sci 17:. 2016
    ..Taken together, AL7 has emerged as a potential lead worthy of further characterization and testing in suitable in vivo models of AD. ..
  29. pmc Conformationally constrained histidines in the design of peptidomimetics: strategies for the χ-space control
    Azzurra Stefanucci
    Department of Pharmaceutical Sciences, University of Chieti Pescara G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    Int J Mol Sci 12:2853-90. 2011
    ..Examples of the use of the described analogues to replace native histidine in bioactive peptides are also given...
  30. doi request reprint Synthesis of short cationic antimicrobial peptidomimetics containing arginine analogues
    Leonardo Baldassarre
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66100, Chieti, Italy
    J Pept Sci 18:567-78. 2012
    ..Furthermore, by evaluating hemolytic activity, the synthesized compounds did not reveal cytotoxic activities, except for compound 5...
  31. ncbi request reprint N-(tert)-butyloxycarbonyl)-beta,beta-cyclopentyl-cysteine (acetamidomethyl)-methyl ester for synthesis of novel peptidomimetic derivatives
    Adriano Mollica
    Dipartimento di Scienze del Farmaco, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    Protein Pept Lett 17:925-9. 2010
    ....
  32. ncbi request reprint Synthesis and preliminary pharmacological evaluation of trans-2-amino-5(6)-chloro-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes as dopamine receptor ligands
    Antonio Di Stefano
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti, Italy
    Farmaco 57:303-13. 2002
    ..The results suggest that introduction of chlorine substituent in five or six position of previously synthesized trans-2-amino-6(5)-hydroxy-1-phenyl-2,3-dihydro-1H-indenes decreases both D1-like and D2-like receptor affinity...