D Caccamo


Affiliation: University of Messina
Country: Italy


  1. Caccamo D, Ferlazzo N, Currò M, Ricca S, Ientile R. Transglutaminase 2 Up-Regulation Is Associated with Inflammatory Response in PBMC from Healthy Subjects with Hypovitaminosis D. Med Sci (Basel). 2018;6: pubmed publisher
    ..The present findings confirm that an increase in TG2 expression exacerbates the activation of NF-κB and the production of pro-inflammatory cytokines, and suggest a link between vitamin D deficiency, TG2 up-regulation, and inflammation. ..
  2. Pandolfo G, Gugliandolo A, Gangemi C, Arrigo R, Currò M, La Ciura G, et al. Association of the COMT synonymous polymorphism Leu136Leu and missense variant Val158Met with mood disorders. J Affect Disord. 2015;177:108-13 pubmed publisher
    ..The small size of our study cohort may limit the generalizability of the present findings. This work first showed the association of combined Leu136Leu and Val158Met variants of COMT gene with MDD and BD. ..
  3. Santoro D, Buemi M, Gagliostro G, Vecchio M, Currò M, Ientile R, et al. Association of VDR gene polymorphisms with heart disease in chronic kidney disease patients. Clin Biochem. 2015;48:1028-32 pubmed publisher
    ..Thus, the screening for VDR variants should be regarded as a way to better address preventive strategies and improving the management of CKD co-morbid conditions. ..
  4. Currò M, Di Mauro D, Bruschetta D, D Amico F, Vecchio M, Trimarchi F, et al. Influence of MTHFR polymorphisms on cardiovascular risk markers in elite athletes. Clin Biochem. 2016;49:183-5 pubmed publisher
    ..Elite hurdlers, having an unfavorable MTHFR genotype are exposed to increased cardiovascular risk, dependent on alterations of homocysteine and AOPP plasma levels. ..
  5. Gugliandolo A, Gangemi C, Caccamo D, Currò M, Pandolfo G, Quattrone D, et al. The RS685012 Polymorphism of ACCN2, the Human Ortholog of Murine Acid-Sensing Ion Channel (ASIC1) Gene, is Highly Represented in Patients with Panic Disorder. Neuromolecular Med. 2016;18:91-8 pubmed publisher
    ..These results are suggestive for a role of ACCN2 rs685012 polymorphism in PD development in Caucasian people. ..
  6. Currò M, Russo T, Ferlazzo N, Caccamo D, Antonuccio P, Arena S, et al. Anti-Inflammatory and Tissue Regenerative Effects of Topical Treatment with Ozonated Olive Oil/Vitamin E Acetate in Balanitis Xerotica Obliterans. Molecules. 2018;23: pubmed publisher
    ..A randomized clinical trial on a large number of children affected by BXO might be useful to verify the efficacy of topical treatment with OZOILE®. ..
  7. Caccamo D, Ricca S, Currò M, Ientile R. Health Risks of Hypovitaminosis D: A Review of New Molecular Insights. Int J Mol Sci. 2018;19: pubmed publisher
    ..This review will focus on the emerging evidence about non-classical biological functions of vitamin D in various disorders. ..
  8. Gugliandolo A, Gangemi C, Calabrò C, Vecchio M, Di Mauro D, Renis M, et al. Assessment of glutathione peroxidase-1 polymorphisms, oxidative stress and DNA damage in sensitivity-related illnesses. Life Sci. 2016;145:27-33 pubmed publisher
    ..However, these differences were not associated to GPx1 genetic background. GPx1 rs1800668 polymorphism does not play a major role in SRI-related oxidative stress development. ..
  9. Ferlazzo N, Currò M, Zinellu A, Caccamo D, Isola G, Ventura V, et al. Influence of MTHFR Genetic Background on p16 and MGMT Methylation in Oral Squamous Cell Cancer. Int J Mol Sci. 2017;18: pubmed publisher
    ..The frequency of p16 and MGMT methylation was around 60% in patients with either the CT/AC or TT/AA genotype. Our results suggest that hypermethylation of cancer-related genes may be affected by MTHFR polymorphisms. ..

More Information


  1. request reprint
    Caccamo D, Gorgone G, Currò M, Parisi G, Di Iorio W, Menichetti C, et al. Effect of MTHFR polymorphisms on hyperhomocysteinemia in levodopa-treated Parkinsonian patients. Neuromolecular Med. 2007;9:249-54 pubmed
    ..A better understanding of the role of homocysteine and MTHFR genotypes in PD is needed to reveal novel approaches for disease management. ..
  2. Russo T, Currò M, Barbera A, Caccamo D, Antonuccio P, Arena S, et al. Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans. Int J Mol Sci. 2016;17: pubmed publisher
    ..Increased expression of TG2 can be the result of chronic inflammation. TG2 overexpression can play a pivotal role in triggering and maintaining the inflammatory response in BXO patients. ..