Gianni Bussolati

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi The mandate for a proper preservation in histopathological tissues
    Maria Comănescu
    Victor Babes Institute, Bucharest, Romania
    Rom J Morphol Embryol 53:233-42. 2012
  2. ncbi Critical steps in tissue processing in histopathology
    Maria Comănescu
    Victor Babes Institute, Bucharest, Romania, Spl Independentei 99 101, 050096 Bucharest Romania
    Recent Pat DNA Gene Seq 6:22-32. 2012
  3. ncbi Technical pitfalls potentially affecting diagnoses in immunohistochemistry
    G Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Turin, Torino, Italy
    J Clin Pathol 61:1184-92. 2008
  4. ncbi Pleomorphism of the nuclear envelope in breast cancer: a new approach to an old problem
    Gianni Bussolati
    Department of Biomedical Science and Human Oncology, University of Torino, Via Santena, Torino, Italy
    J Cell Mol Med 12:209-18. 2008
  5. ncbi A modified Trastuzumab antibody for the immunohistochemical detection of HER-2 overexpression in breast cancer
    G Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Turin, Torino, Italy
    Br J Cancer 92:1261-7. 2005
  6. ncbi Tissue arrays as fiducial markers for section alignment in 3-D reconstruction technology
    G Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, 10126, Italy
    J Cell Mol Med 9:438-45. 2005
  7. ncbi Proper detection of the nuclear shape: ways and significance
    G Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Torino, Italy
    Rom J Morphol Embryol 49:435-9. 2008
  8. ncbi Oxytocin induces proliferation and migration in immortalized human dermal microvascular endothelial cells and human breast tumor-derived endothelial cells
    Paola Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, Italy
    Mol Cancer Res 4:351-9. 2006
  9. ncbi Technical limits of comparison of step-sectioning,immunohistochemistry and RT-PCR on breast cancer sentinel nodes: a study on methacarn-fixed tissue
    Lorenzo Daniele
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    J Cell Mol Med 13:4042-50. 2009
  10. ncbi Added value of combined gene and protein expression of CK20 and CEA in non-macroscopically involved lymph nodes of colorectal cancer
    Giuseppe D'Armento
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Int J Surg Pathol 17:93-8. 2009

Detail Information

Publications83

  1. ncbi The mandate for a proper preservation in histopathological tissues
    Maria Comănescu
    Victor Babes Institute, Bucharest, Romania
    Rom J Morphol Embryol 53:233-42. 2012
    ..Concrete issues, techniques and pitfalls, as well as proposed guidelines for processing the tissues are shown in this presentation...
  2. ncbi Critical steps in tissue processing in histopathology
    Maria Comănescu
    Victor Babes Institute, Bucharest, Romania, Spl Independentei 99 101, 050096 Bucharest Romania
    Recent Pat DNA Gene Seq 6:22-32. 2012
    ..Moreover, a major advance is reported in this study, the observation that tissue fixation in cold conditions allows a much better preservation of nucleic acid sequences...
  3. ncbi Technical pitfalls potentially affecting diagnoses in immunohistochemistry
    G Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Turin, Torino, Italy
    J Clin Pathol 61:1184-92. 2008
    ..Experience on the antigen retrieval procedures for different antigens is also presented...
  4. ncbi Pleomorphism of the nuclear envelope in breast cancer: a new approach to an old problem
    Gianni Bussolati
    Department of Biomedical Science and Human Oncology, University of Torino, Via Santena, Torino, Italy
    J Cell Mol Med 12:209-18. 2008
    ..Decoration of the NE might thus be regarded as a novel diagnostic parameter to define the grade of malignancy, which parallels and enhances that provided by routine histological procedures...
  5. ncbi A modified Trastuzumab antibody for the immunohistochemical detection of HER-2 overexpression in breast cancer
    G Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Turin, Torino, Italy
    Br J Cancer 92:1261-7. 2005
    ..Biotinylated Trastuzumab can thus be used for immunohistochemical detection of HER-2 overexpression in breast cancer, and has the potential to identify patients likely to benefit from Trastuzumab treatment...
  6. ncbi Tissue arrays as fiducial markers for section alignment in 3-D reconstruction technology
    G Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, 10126, Italy
    J Cell Mol Med 9:438-45. 2005
    ..This original methodology of incorporating Tissue Arrays into paraffin blocks as fiducial markers for three-dimensional reconstruction has a potential impact on histology for research purposes and diagnostic applications...
  7. ncbi Proper detection of the nuclear shape: ways and significance
    G Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Torino, Italy
    Rom J Morphol Embryol 49:435-9. 2008
    ..Finally, the prognostic importance of detecting irregularities of the nuclear shape in breast carcinomas by immunofluorescence staining for nuclear proteins will be discussed...
  8. ncbi Oxytocin induces proliferation and migration in immortalized human dermal microvascular endothelial cells and human breast tumor-derived endothelial cells
    Paola Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, Italy
    Mol Cancer Res 4:351-9. 2006
    ..Altogether, these data indicate that oxytocin contributes to cell motility and growth in HMEC and B-TEC...
  9. ncbi Technical limits of comparison of step-sectioning,immunohistochemistry and RT-PCR on breast cancer sentinel nodes: a study on methacarn-fixed tissue
    Lorenzo Daniele
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    J Cell Mol Med 13:4042-50. 2009
    ..We believe that only prospective studies with quantitative mRNA analysis of specific metastatic markers on the whole lymph node can elucidate the utility of molecular assessments of SLN...
  10. ncbi Added value of combined gene and protein expression of CK20 and CEA in non-macroscopically involved lymph nodes of colorectal cancer
    Giuseppe D'Armento
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Int J Surg Pathol 17:93-8. 2009
    ..This approach offers a technological framework for further studies that aim to validate the clinical significance of protein/mRNA expression of tumor markers in colorectal cancer sentinel lymph nodes...
  11. ncbi Expression of p63 is the sole independent marker of aggressiveness in localised (stage I-II) Merkel cell carcinomas
    Sofia Asioli
    Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy
    Mod Pathol 24:1451-61. 2011
    ..0001). The present data indicate that p63 expression is associated with a worse prognosis in patients with Merkel cell carcinoma, and in localised tumours it represents the single independent predictor of clinical evolution...
  12. ncbi Cytological detection of papillary thyroid carcinomas by nuclear membrane decoration with emerin staining
    Sofia Asioli
    Department of Biomedical Sciences and Human Oncology, Molinette Hospital, University of Turin, Via Santena 7, 10126, Turin, Italy
    Virchows Arch 457:43-51. 2010
    ....
  13. ncbi Routine assessment of prognostic factors in breast cancer using a multicore tissue microarray procedure
    Anna Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126, Turin, and Division of Pathology, Vito Fazzi Hospital, Lecce, Italy
    Virchows Arch 449:288-96. 2006
    ..In conclusion, multicore TMA may be an efficient approach in the routine study of prognostic factors in breast cancer, significantly reducing costs, time, and burden of slides necessary to accomplish these mandatory tests...
  14. ncbi Estrogen receptor alpha is a novel marker expressed by follicular dendritic cells in lymph nodes and tumor-associated lymphoid infiltrates
    Anna Sapino
    Department of Biomedical Science and Human Oncology, University of Turin Medical School, Turin, Italy
    Am J Pathol 163:1313-20. 2003
    ..Taken together, these results open new perspectives on the effects of sex steroids and their antagonists on the human response in cancer and inflammation...
  15. ncbi Estrogen receptor-beta is expressed in stromal cells of fibroadenoma and phyllodes tumors of the breast
    Anna Sapino
    Department of Biomedical Science and Human Oncology, University of Torino, Torino, Italy
    Mod Pathol 19:599-606. 2006
    ..Conversely, the older age of patients with ER-beta-rich phyllodes tumors suggests that mechanisms, probably independent from estrogen stimulation, act on the growth of these tumors...
  16. ncbi Oxytocin synthesis within the normal and neoplastic breast: first evidence of a local peptide source
    Paola Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy
    Int J Oncol 28:1263-8. 2006
    ..These data altogether suggest the existence of a local OT source within the normal as well as within the neoplastic breast, and that such synthesis can be modulated by E2...
  17. ncbi Fluorescent in situ hybridization as a screening test for HER2 amplification in G2 and G3 breast cancers of lobular and ductal histotype and metastases
    Isabella Castellano
    Department of Biomedical Sciences and Human Oncology, University of Turin, 10126 Turin, Italy
    Oncol Rep 19:1271-5. 2008
    ..These data suggest that the HER2 FISH analysis may be an effective screening test in breast cancer metastases and G3 tumors, irrespective of the hormone receptor status or presence of lymphovascular invasion...
  18. ncbi Neuroendocrine differentiation in breast cancer: established facts and unresolved problems
    Luisella Righi
    Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Orbassano, Torino, Italy
    Semin Diagn Pathol 27:69-76. 2010
    ..The clinical effect of neuroendocrine breast cancer is still a matter of debate; however, when compared with unselected breast cancers, NEBCs show a less aggressive clinical behavior...
  19. ncbi Emerin immunohistochemistry reveals diagnostic features of nuclear membrane arrangement in thyroid lesions
    Sofia Asioli
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    Histopathology 54:571-9. 2009
    ..The aim was to focus on the immunohistochemistry of emerin, a protein of the NM whose decoration best demarcates the nuclear shape...
  20. ncbi Evidence of oxytocin/oxytocin receptor interplay in human prostate gland and carcinomas
    Paola Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena, I-10126 Torino, Italy
    Int J Oncol 25:899-904. 2004
    ..Altogether, the data indicate that the OT/OTR system could be involved in the control of prostate neoplastic pathology...
  21. ncbi Myxoid renal tumor with myoepithelial differentiation mimicking a salivary gland pleomorphic adenoma: description of a case
    Donatella Pacchioni
    Department of Biomedical Science, University of Turin, Italy
    Am J Surg Pathol 31:632-6. 2007
    ..A definitive classification and histogenetic interpretation of this previously unreported tumor type awaits description of further cases showing similar features which, perhaps, as it may happen, went so far unnoticed...
  22. ncbi Cell membrane reactivity of MIB-1 antibody to Ki67 in human tumors: fact or artifact?
    Eugenio Leonardo
    Division of Pathology, San Luigi Hospital, Orbassano, Torino, Italy
    Appl Immunohistochem Mol Morphol 15:220-3. 2007
    ..We conclude that when Ki67 immunohistochemistry is used for diagnostic purposes in a suspected HTT, only MIB-1 clone at room temperature should be employed...
  23. ncbi Oxytocin modulates estrogen receptor alpha expression and function in MCF7 human breast cancer cells
    Paola Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    Int J Oncol 21:375-8. 2002
    ..This is the first evidence that OT modulates the expression of ERalpha receptors in human neoplastic cells...
  24. ncbi Anti-angiogenic properties of calcium trifluoroacetate
    Benedetta Bussolati
    Department of Internal Medicine, Centre for Molecular Biotechnology, University of Turin, Italy
    Microvasc Res 78:272-7. 2009
    ..These results are the first to suggest that CaTFAc may be useful for the treatment of diseases caused by enhanced angiogenesis...
  25. ncbi Diagnosis of biliary tract lesions by histological sectioning of brush bristles as alternative to cytological smearing
    Sofia Asioli
    Department of Biomedical Sciences and Human Oncology, Molinette Hospital, University of Turin, Turin, Italy
    Am J Gastroenterol 103:1274-81. 2008
    ..To increase the diagnostic potential of endoscopic biliary tract brushing, we devised an approach alternative to cytological smearing, leading to the preoperative histological examination of the collected material...
  26. ncbi "Benign" metastatic meningioma: clinico-pathological analysis of one case metastasising to the lung and overview on the concepts of either primitive or metastatic meningiomas of the lung
    Sofia Asioli
    Department of Biomedical Sciences and Human Oncology Molinette Hospital, University of Turin, Via Santena 7, 10100, Turin, Italy
    Virchows Arch 450:591-4. 2007
    ..They represent a typical example of "benign" tumours that may implant to the lung similar to other tumours, definitely considered benign but reported to rarely present unusual secondary localization...
  27. ncbi Androgen receptor expression is a significant prognostic factor in estrogen receptor positive breast cancers
    Isabella Castellano
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126, Turin, Italy
    Breast Cancer Res Treat 124:607-17. 2010
    ..017, HR 0.521, 95%CI 0.306-0.888) and DSS (P = 0.001, HR 0.276, 95% CI 0.130-0.588). AR expression is an independent prognostic factor of better outcome in patients with ER-positive breast cancers...
  28. ncbi Potential applications of molecular biology in neuroendocrine tumors
    Tommaso Emmer
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    Endocr Pathol 14:319-28. 2003
    ..g., oxytocin and somatostatin receptors) and the development of potent synthetic analogs of such peptides, are opening promising applications in the diagnosis and therapy of endocrine tumors...
  29. ncbi Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach
    Marco Volante
    Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Turin, Italy
    Am J Surg Pathol 31:1256-64. 2007
    ..An algorithmic approach was devised for practical use in the diagnosis of this tumor...
  30. ncbi Predicting gefitinib responsiveness in lung cancer by fluorescence in situ hybridization/chromogenic in situ hybridization analysis of EGFR and HER2 in biopsy and cytology specimens
    Lorenzo Daniele
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    Mol Cancer Ther 6:1223-9. 2007
    ....
  31. ncbi Confocal microscope analysis and tridimensional reconstruction of papillary thyroid carcinoma nuclei
    Mauro Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Virchows Arch 444:350-5. 2004
    ....
  32. ncbi The pre-lymphatic pathway, the rooths of the lymphatic system in breast tissue: a 3D study
    Sofia Asioli
    Department of Biomedical Sciences and Human Oncology, Molinette Hospital, University of Turin, Via Santena 7, 10126, Turin, Italy
    Virchows Arch 453:401-6. 2008
    ..The present findings suggest that the existence of pre-lymphatics has to be taken in consideration in the intramammary spread of malignant tumours...
  33. ncbi Microcystic urothelial cell carcinoma with neuroendocrine differentiation arising in renal pelvis. Report of a case
    Donatella Pacchioni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126, Turin, Italy
    Virchows Arch 454:223-7. 2009
    ..Immunohistochemical analysis confirmed the urothelial histotype (positive for thrombomodulin, p63 and high-molecular-weight cytokeratins) and disclosed focal neuroendocrine differentiation...
  34. ncbi Role of CD31/platelet endothelial cell adhesion molecule-1 expression in in vitro and in vivo growth and differentiation of human breast cancer cells
    Luisella Righi
    Department of Genetics, Biology, and Biochemistry, Laboratory of Immunogenetics, University of Torino Medical School, Torino, Italy
    Am J Pathol 162:1163-74. 2003
    ..In conclusion, CD31 expression reverts the undifferentiated morphology and aggressive behavior of MDA-MB-231 cells, indicating its active role in the morphogenesis of breast ductal in situ carcinomas...
  35. ncbi Preliminary experience with a new cytology brush in EUS-guided FNA
    Mauro Bruno
    Department of Gastro Hepatology, Molinette Hospital, Torino, Italy
    Gastrointest Endosc 70:1220-4. 2009
    ..Recently, the EchoBrush (Cook Endoscopy, Winston-Salem, NC), a disposable cytologic brush, was introduced to the market. To date, only 1 study, limited to 10 pancreatic cyst cases, using this device has been published...
  36. ncbi Formalin fixation at low temperature better preserves nucleic acid integrity
    Gianni Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    PLoS ONE 6:e21043. 2011
    ..In conclusion, CF preserves tissues and nucleic acids, enabling reliable gene expression profiling of fixed tissues...
  37. ncbi p63 expression as a new prognostic marker in Merkel cell carcinoma
    Sofia Asioli
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Cancer 110:640-7. 2007
    ..Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumor, mostly affecting elderly individuals. The histogenesis of this rare tumor as well as its prognostic criteria are a matter of dispute...
  38. ncbi Merits of the PMiT (papillary microtumor) terminology in the definition of a subset of incidental papillary microcarcinomas of the thyroid
    Sofia Asioli
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    Int J Surg Pathol 17:378-83. 2009
    ....
  39. ncbi Galectin-3 expression in parathyroid carcinoma: immunohistochemical study of 26 cases
    Nicoletta Bergero
    Division of Pathology, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, 10043 Prbassano, Italy
    Hum Pathol 36:908-14. 2005
    ..We conclude that Gal-3 immunostaining is a valuable tool to support a diagnosis of PC in highly proliferating (Ki67 >6%) tumors affecting a single parathyroid gland...
  40. ncbi Cytologic features of metanephric adenoma of the kidney during pregnancy: a case report
    Martino Bosco
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Acta Cytol 51:468-72. 2007
    ..However, cytologic appearance of MA is not well characterized...
  41. ncbi Goblet cell carcinoids and other mixed neuroendocrine/nonneuroendocrine neoplasms
    Marco Volante
    Department of Clinical and Biological Sciences, University of Turin and San Luigi Hospital, Regione Gonzole10, 10043, Orbassano, Torino, Italy
    Virchows Arch 451:S61-9. 2007
    ..Moreover, molecular and clinical aspects, which might help to understand their possible histogenesis and biological behavior, will be reviewed...
  42. ncbi Late recurrence of Wilms' tumour with exclusive skeletal muscle phenotype 23 years after primary diagnosis
    Rebecca Senetta
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126, Turin, Italy
    Virchows Arch 450:115-8. 2007
    ..The latter results in a high degree of differentiation and a long disease-free interval after the first diagnosis...
  43. ncbi Poorly differentiated carcinoma of the thyroid: validation of the Turin proposal and analysis of IMP3 expression
    Sofia Asioli
    Division of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
    Mod Pathol 23:1269-78. 2010
    ..Expression of IMP3 appears to be an adverse prognostic factor for poorly differentiated thyroid carcinoma...
  44. ncbi RAS mutations are the predominant molecular alteration in poorly differentiated thyroid carcinomas and bear prognostic impact
    Marco Volante
    Department of Clinical and Biological Sciences, San Luigi Hospital, 10043 Orbassano, Italy
    J Clin Endocrinol Metab 94:4735-41. 2009
    ..Recently homogeneous diagnostic criteria have been proposed by our group (Turin proposal) that need to be complemented by detailed molecular characterization...
  45. ncbi Classic and recent special stains used in differential diagnosis of endocrine tumors
    G Bussolati
    Department of Biomedical Sciences and Oncology, University of Turin, Via Santena 7, I 10126 Turin, Italy
    Endocr Pathol 12:379-87. 2001
    ....
  46. ncbi [Histological sectioning of brush bristles allows an improved diagnosis of biliary tract lesions]
    S Asioli
    Dipartimento di Scienze Biomediche e Oncologia, Universita degli Studi di Torino, Torino, Italy
    Minerva Med 98:373-8. 2007
    ..Small fragments of the mucosa, of inflammatory cell aggregates or of carcinomas are observed and the results are optimally fixed and allow a definitive histological diagnosis...
  47. ncbi Expression of apocrine differentiation markers in neuroendocrine breast carcinomas of aged women
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Mod Pathol 14:768-76. 2001
    ..In addition, the possibility for using Chs or GCDFP-15 serum values in the follow-up of these patients, as demonstrated in two cases of the present series, can justify the immunophenotyping of the tumors...
  48. ncbi Clinical significance of neuroendocrine carcinoma of the breast
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Ann Oncol 12:S115-7. 2001
    ..In the present work, the clinical significance of pure' NE differentiation in breast carcinoma and of its 'variants' will be analyzed...
  49. ncbi Ultrasonographically-guided fine-needle aspiration of axillary lymph nodes: role in breast cancer management
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Br J Cancer 88:702-6. 2003
    ..This presurgical protocol is reliable for screening patients with LN metastases that should proceed directly to axillary dissection or adjuvant chemotherapy, thus avoiding sentinel lymph node biopsy...
  50. ncbi Biological relevance of oxytocin and oxytocin receptors in cancer cells and primary tumors
    P Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Ann Oncol 12:S37-9. 2001
    ....
  51. ncbi Expression of somatostatin receptor types 2, 3 and 5 in biopsies and surgical specimens of human lung tumours. Correlation with preoperative octreotide scintigraphy
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    Virchows Arch 439:787-97. 2001
    ..IHC can therefore be usefully coupled to radionuclear investigations to better characterize the sst cellular location and subtype in lung tumors...
  52. ncbi Is detection of endocrine cells in breast adenocarcinoma of diagnostic and clinical significance?
    A Sapino
    Department of Biomedical Sciences and Human Oncology University of Torino, Torino, Italy
    Histopathology 40:211-4. 2002
  53. ncbi Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Virchows Arch 440:461-75. 2002
    ..It is concluded that SSTRs 1-5 are heterogeneously expressed in GEP endocrine tumors and that IHC is a reliable tool to detect SSTR types 2, 3 and 5 in surgical and biopsy specimens...
  54. ncbi Patients with advanced stage breast carcinoma immunoreactive to biotinylated Herceptin are most likely to benefit from trastuzumab-based therapy: an hypothesis-generating study
    A Sapino
    Dipartimento di Scienze Biomediche e Oncologia Umana, Universita di Torino, Torino, Italy
    Ann Oncol 18:1963-8. 2007
    ..We previously showed that BiotHER immunoreactivity is highly correlated with HER2 amplification and indicated that it could be associated with better clinical outcome in advanced breast cancer patients receiving trastuzumab...
  55. ncbi Which breast carcinomas need HER-2/neu gene study after immunohistochemical analysis? Results of combined use of antibodies against different c-erbB2 protein domains
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Torino Medical School, Italy
    Histopathology 43:354-62. 2003
    ..Evaluation of HER2 gene amplification in breast cancers is a compelling, routine procedure. The aim of this work was to evaluate which breast carcinomas would really benefit from HER-2/neu gene analysis...
  56. ncbi Assessment of necrosis and hypoxia in ductal carcinoma in situ of the breast: basis for a new classification
    G Bussolati
    Department of Biomedical Sciences and Oncology, University of Torino, Italy
    Virchows Arch 437:360-4. 2000
    ....
  57. ncbi RET/PTC activation in hyalinizing trabecular tumors of the thyroid
    M Papotti
    Dipartimenti di Anatomia Patologica, Universita di Torino, Italy
    Am J Surg Pathol 24:1615-21. 2000
    ..6%) of HTTs and papillary carcinomas exhibit the same RET proto-oncogene alterations. Thus, HTT may represent the "hyalinizing trabecular" variant of papillary carcinoma rather than a separate entity...
  58. ncbi 111In-labeled 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid-lys(8)-vasotocin: a new powerful radioligand for oxytocin receptor-expressing tumors
    G Bussolati
    Department of Biomedical Sciences and Human Oncology, University of Torino, Vai Santena 7, 10126 Torino, Italy
    Cancer Res 61:4393-7. 2001
    ..The present study opens new perspectives for imaging and, possibly, therapy of OTR-positive human tumors such as breast and endometrial carcinomas, neuroblastomas, and glioblastomas...
  59. ncbi Oxytocin and oxytocin receptors in cancer cells and proliferation
    P Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy
    J Neuroendocrinol 16:362-4. 2004
    ....
  60. ncbi Absence of RET gene point mutations in sporadic thyroid C-cell hyperplasia
    Enrico Saggiorato
    Section of Endocrinology, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano, Italy
    J Mol Diagn 9:214-9. 2007
    ....
  61. ncbi Heterogeneous versus homogeneous genetic nature of multiple foci of in situ carcinoma of the breast
    Marco Volante
    Department of Biomedical Sciences and Oncology, University of Turin, Italy
    Hum Pathol 34:1163-9. 2003
    ..Such a small subgroup of in situ cancers affecting diffusely the entire breast and originating from independent foci presents both clinical and pathogenetic interest...
  62. ncbi Secretogranin II expression in Ewing's sarcomas and primitive neuroectodermal tumors
    A Pagani
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Diagn Mol Pathol 1:165-72. 1992
    ..This result supports the hypothesis that some Ewing's sarcomas represent a most primitive form of neuroectodermal tumor; in addition, it indicates a diagnostic role of SgII in cases of Ewing's sarcomas and PNETs...
  63. ncbi 34betaE12 cytokeratin immunodetection in the differential diagnosis of neuroendocrine carcinomas of the breast
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    Appl Immunohistochem Mol Morphol 9:229-33. 2001
    ..HMW CK can be added to the list of markers useful in the differential diagnosis of NE from non-NE tumors...
  64. ncbi Telocytes are the common cell of origin of both PEComas and GISTs: an evidence-supported hypothesis
    Carmen Ardeleanu
    Victor Babes Institute, Bucharest, Romania Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    J Cell Mol Med 15:2569-74. 2011
    ..In conclusion we propose that telocytes could be the common cells of origin for both PEComas and GISTs...
  65. ncbi Oxytocin is a growth factor for Kaposi's sarcoma cells: evidence of endocrine-immunological cross-talk
    Paola Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Cancer Res 62:2406-13. 2002
    ....
  66. ncbi Detection procedures for neuroblastoma cells metastatic to blood and bone marrow: blinded comparison of chromogranin A heminested reverse transcription polymerase chain reaction to tyrosine hydroxylase nested reverse transcription polymerase chain reactio
    Alberto Pagani
    Department of Biomedical Sciences and Human Oncology, University of Torino, Italy/ASL10, Pathology Service, Pinerolo, Italy
    Diagn Mol Pathol 11:98-106. 2002
    ..Our data support the potential usefulness of CgA heminested RT-PCR as a specific and sensitive procedure for minimal disease detection in neuroblastoma. A prospective evaluation of this tool in clinical studies might be warranted...
  67. ncbi Clinico-pathological features of a series of 11 oncocytic endocrine tumours of the pancreas
    Marco Volante
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126, Turin, and Department of Pathology, Ospedale di Circolo, Varese, Italy
    Virchows Arch 448:545-51. 2006
    ....
  68. ncbi Growth inhibition of DMBA-induced rat mammary carcinomas by UK 114
    S Racca
    Department of Biological and Clinical Sciences, University of Turin, Italy
    Virchows Arch 431:323-8. 1997
    ..The mechanism of the tumour inhibitory activity of UK 114 is probably related to induction of immunosurveillance...
  69. ncbi A new vision of tubular and tubulo-lobular carcinomas of the breast, as revealed by 3-D modelling
    C Marchio
    Department of Biomedical Sciences and Human Oncology, University of Turin, Torino, Italy
    Histopathology 48:556-62. 2006
    ..To reveal architectural structure and growth patterns of tubular carcinomas (TC) and tubulo-lobular carcinomas (TLC) of the breast...
  70. ncbi Prostatic duct carcinoma with combined prostatic duct adenocarcinoma and urothelial carcinoma features: report of a case
    D Pacchioni
    Department of Urologic Pathology, University of Turin, Italy
    Int J Surg Pathol 12:293-7. 2004
    ..The proliferation index was high (60%), and p53 was diffusely expressed (55%). The incidence and significance of PDC with combined features is discussed with reference to literature data...
  71. ncbi Argyrophilic neuroendocrine carcinoma of the male breast
    M Papotti
    Department of Human Oncology, University of Turin, Torino, Italy
    Ultrastruct Pathol 17:115-21. 1993
    ..Argyrophilia, expression of chromogranins at both protein and gene level, and the presence of dense granules of the neurosecretory type by electron microscopy were demonstrated...
  72. ncbi Histology far away from Flatland: 3D roller-coasting into grade-dependent angiogenetic patterns in oligodendrogliomas
    P Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    J Cell Mol Med 12:564-8. 2008
    ..We use here surgical specimens derived from oligodendrogliomas as a model for a novel elucidative 3D reconstruction of the grade-dependent vascular arborisation in brain tumours...
  73. ncbi Nuclear shape in papillary thyroid carcinoma: a role for lamin B receptor?
    D Recupero
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Rom J Morphol Embryol 51:615-20. 2010
    ..In conclusion, our data suggest that LBR is heavily expressed in PTC cells, but an abnormal folding of the protein might explain its lack of immunohistochemical reactivity and be associated with the anomalous folding of the NM...
  74. ncbi p27(kip1) immunoreactivity correlates with long-term survival in pleural malignant mesothelioma
    M Bongiovanni
    Department of Oncology, University of Turin, Turin, Italy
    Cancer 92:1245-50. 2001
    ..p27(kip1) represents a reliable additional predictive factor for PMMs and a useful marker to identify patients having a more favorable prognosis...
  75. ncbi Progression from superficial to invasive carcinoma of the bladder: genetic evidence of either clonal heterogeneous events
    M Volante
    Department of Biomedical Sciences and Oncology, University of Turin, Turin, Italy
    Hum Pathol 32:468-74. 2001
    ....
  76. ncbi Extensive DNA fragmentation in oxyphilic cell lesions of the thyroid
    M Volante
    Departments of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    J Histochem Cytochem 49:1003-11. 2001
    ..These findings are consistent with an extensive DNA fragmentation peculiar to oxyphilic cells, which is not directly related to apoptosis and whose origin and biological significance are presently unknown...
  77. ncbi In situ hybridization in viral hepatitis
    F Negro
    Division of Gastroenterology, Molinette Hospital, Turin, Italy
    Liver 12:217-26. 1992
    ..Although ISH is a powerful tool for the molecular biologist, its clinical significance in the diagnosis and prognosis of human hepatitis virus infections has yet to be fully evaluated...
  78. ncbi [On-site evaluation and triage for endoscopic ultrasound-guided fine needle aspiration cytology. The Turin experience]
    P Campisi
    Dipartimento di Scienze Biomediche e Oncologia, Universita degli Studi di Torino, Torino, Italy
    Minerva Med 98:395-400. 2007
    ....
  79. ncbi Bronchiolar columnar cell dysplasia--genetic analysis of a novel preneoplastic lesion of peripheral lung
    Reinhard Ullmann
    Laboratory of Molecular Cytogenetics, Institute of Pathology, Auenbruggerplatz 25, 8036, Graz, Austria
    Virchows Arch 442:429-36. 2003
    ..Summarizing our data from morphological and genetic analysis, we conclude that BCCD is a preneoplasia of the bronchiolar epithelium and most probably represents an additional precursor lesion of lung adenocarcinomas...
  80. ncbi Constitutive and ligand-induced nuclear localization of oxytocin receptor
    Conan G Kinsey
    Department of Biology, Bucknell University, Lewisburg, PA, USA
    J Cell Mol Med 11:96-110. 2007
    ....
  81. ncbi A novel fixative improves opportunities of nucleic acids and proteomic analysis in human archive's tissues
    Giorgio Stanta
    Department of Clinical, Morphological and Technological Sciences, University of Trieste, 34149 Trieste, Italy
    Diagn Mol Pathol 15:115-23. 2006
    ..Protein extracts from FineFix treated tissues were also compared with fresh tissues'ones by two dimensional electrophoresis, demonstrating that the protein pattern were well comparable for number and distribution of the spots...
  82. ncbi Of GISTs and EGISTs, ICCs and ICs
    Gianni Bussolati
    Virchows Arch 447:907-8. 2005
  83. ncbi Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study
    Armando Bartolazzi
    Department of Pathology, St Andrea University Hospital, Rome, Italy
    Lancet Oncol 9:543-9. 2008
    ..We aimed to assess the diagnostic effect of galectin-3 expression analysis in distinguishing preoperatively benign from malignant follicular thyroid nodules when FNA findings were indeterminate...