Jorge Burns

Summary

Affiliation: University Hospital of Modena and Reggio Emilia
Location: Modena, Italy
Summary:
Associate Investigator examining the use of Adult Mesenchymal Stromal (Stem) Cells for use in Tissue Engineering Bone and as Therapeutic Agents for Cancer.

Publications

  1. pmc Decellularized matrix from tumorigenic human mesenchymal stem cells promotes neovascularization with galectin-1 dependent endothelial interaction
    Jorge S Burns
    Molecular Endocrinology Laboratory KMEB, Department of Endocrinology and Metabolism, Odense University Hospital, University of Southern Denmark, Odense, Denmark
    PLoS ONE 6:e21888. 2011
  2. ncbi request reprint Stepwise transformation of primary thyroid epithelial cells by a mutant Ha-ras oncogene: an in vitro model of tumor progression
    J S Burns
    Department of Pathology, University of Wales College of Medicine, Cardiff, United Kingdom
    Mol Carcinog 6:129-39. 1992
  3. ncbi request reprint The histopathology of a human mesenchymal stem cell experimental tumor model: support for an hMSC origin for Ewing's sarcoma?
    J S Burns
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Histol Histopathol 23:1229-40. 2008
  4. pmc The use of hTERT-immortalized cells in tissue engineering
    Moustapha Kassem
    Department of Endocrinology and Metabolism, University Hospital of Odense, DK 5000, Odense C, Denmark
    Cytotechnology 45:39-46. 2004
  5. pmc Epigenetic modulation of cancer-germline antigen gene expression in tumorigenic human mesenchymal stem cells: implications for cancer therapy
    Morten Gjerstorff
    Medical Biotechnology Center, University of Southern Denmark, Odense C, Denmark
    Am J Pathol 175:314-23. 2009
  6. doi request reprint Identifying a molecular phenotype for bone marrow stromal cells with in vivo bone-forming capacity
    Kenneth H Larsen
    Laboratory for Molecular Endocrinology KMEB, Department of Endocrinology, University Hospital of Odense and Medical Biotechnology Center, University of Southern Denmark, Odense C, Denmark
    J Bone Miner Res 25:796-808. 2010
  7. doi request reprint Parameters in three-dimensional osteospheroids of telomerized human mesenchymal (stromal) stem cells grown on osteoconductive scaffolds that predict in vivo bone-forming potential
    Jorge S Burns
    Laboratory for Molecular Endocrinology KMEB, Department of Endocrinology and Metabolism, Odense University Hospital and Medical Biotechnology Center, Odense, Denmark
    Tissue Eng Part A 16:2331-42. 2010
  8. doi request reprint Cancer-germline antigen vaccines and epigenetic enhancers: future strategies for cancer treatment
    Morten Frier Gjerstorff
    Odense University Hospital, Sdr Boulevard 29, DK 5000, Odense C, Denmark
    Expert Opin Biol Ther 10:1061-75. 2010
  9. pmc siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells
    Morten Ø Andersen
    Interdisciplinary Nanoscience Center, Aarhus University, Aarhus C, Denmark
    Mol Ther 18:2018-27. 2010
  10. pmc Insulin resistance is not conserved in myotubes established from women with PCOS
    Mette Eriksen
    Department of Endocrinology, Odense University Hospital, Odense, Denmark
    PLoS ONE 5:e14469. 2010

Collaborators

Detail Information

Publications27

  1. pmc Decellularized matrix from tumorigenic human mesenchymal stem cells promotes neovascularization with galectin-1 dependent endothelial interaction
    Jorge S Burns
    Molecular Endocrinology Laboratory KMEB, Department of Endocrinology and Metabolism, Odense University Hospital, University of Southern Denmark, Odense, Denmark
    PLoS ONE 6:e21888. 2011
    ..By exploring the heterogeneity in hMSC-TERT20 clones we aimed to understand molecular mechanisms by which mesenchymal stem cells may promote neovascularization...
  2. ncbi request reprint Stepwise transformation of primary thyroid epithelial cells by a mutant Ha-ras oncogene: an in vitro model of tumor progression
    J S Burns
    Department of Pathology, University of Wales College of Medicine, Cardiff, United Kingdom
    Mol Carcinog 6:129-39. 1992
    ..We postulate that these two phenomena are causally related to each other and to the transformed phenotype...
  3. ncbi request reprint The histopathology of a human mesenchymal stem cell experimental tumor model: support for an hMSC origin for Ewing's sarcoma?
    J S Burns
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Histol Histopathol 23:1229-40. 2008
    ..The phenotype and ontogenesis of hMSC-TERT20 tumors was consistent with the hypothesis that sarcomas may arise from hMSC, providing a unique diploid model for exploring human sarcoma biology...
  4. pmc The use of hTERT-immortalized cells in tissue engineering
    Moustapha Kassem
    Department of Endocrinology and Metabolism, University Hospital of Odense, DK 5000, Odense C, Denmark
    Cytotechnology 45:39-46. 2004
    ..Thus, safety issues should be studied carefully before using the telomerized tissues in the clinic. Alternatively, the development of conditional or intermittent telomerase activation protocols is needed...
  5. pmc Epigenetic modulation of cancer-germline antigen gene expression in tumorigenic human mesenchymal stem cells: implications for cancer therapy
    Morten Gjerstorff
    Medical Biotechnology Center, University of Southern Denmark, Odense C, Denmark
    Am J Pathol 175:314-23. 2009
    ....
  6. doi request reprint Identifying a molecular phenotype for bone marrow stromal cells with in vivo bone-forming capacity
    Kenneth H Larsen
    Laboratory for Molecular Endocrinology KMEB, Department of Endocrinology, University Hospital of Odense and Medical Biotechnology Center, University of Southern Denmark, Odense C, Denmark
    J Bone Miner Res 25:796-808. 2010
    ..Identifying more of these predictive markers would be very useful in the quality control of osteoblastic cells before use in therapy...
  7. doi request reprint Parameters in three-dimensional osteospheroids of telomerized human mesenchymal (stromal) stem cells grown on osteoconductive scaffolds that predict in vivo bone-forming potential
    Jorge S Burns
    Laboratory for Molecular Endocrinology KMEB, Department of Endocrinology and Metabolism, Odense University Hospital and Medical Biotechnology Center, Odense, Denmark
    Tissue Eng Part A 16:2331-42. 2010
    ....
  8. doi request reprint Cancer-germline antigen vaccines and epigenetic enhancers: future strategies for cancer treatment
    Morten Frier Gjerstorff
    Odense University Hospital, Sdr Boulevard 29, DK 5000, Odense C, Denmark
    Expert Opin Biol Ther 10:1061-75. 2010
    ....
  9. pmc siRNA nanoparticle functionalization of nanostructured scaffolds enables controlled multilineage differentiation of stem cells
    Morten Ø Andersen
    Interdisciplinary Nanoscience Center, Aarhus University, Aarhus C, Denmark
    Mol Ther 18:2018-27. 2010
    ..As a consequence of this, we predict that complex tissues and organs can be engineered by the in situ development of multiple cell types guided by spatially restricted nanoparticles...
  10. pmc Insulin resistance is not conserved in myotubes established from women with PCOS
    Mette Eriksen
    Department of Endocrinology, Odense University Hospital, Odense, Denmark
    PLoS ONE 5:e14469. 2010
    ....
  11. ncbi request reprint The best bone marrow stromal cell for therapy is … 'yellow'
    Jorge S Burns
    Cytotherapy 13:644-6. 2011
  12. pmc Understanding tumor-stroma interplays for targeted therapies by armed mesenchymal stromal progenitors: the Mesenkillers
    Giulia Grisendi
    Am J Cancer Res 1:787-805. 2011
    ..The recognition of these distinct stromal functions may help in planning effective and safer approaches aimed either to eradicate or to substitute TS by novel compounds and/or MSC having specific killing activities...
  13. doi request reprint Teratoma formation by human embryonic stem cells is site dependent and enhanced by the presence of Matrigel
    Tatyana A Prokhorova
    Molecular Endocrinology Laboratory KMEB, Department of Endocrinology and Metabolism, University Hospital of Odense and Medical Biotechnology Center, University of Southern Denmark, Winsløwparken, Odense, Denmark
    Stem Cells Dev 18:47-54. 2009
    ..Also, teratoma formation can be employed to study the development defects exhibited by the chromosomally abnormal hESC lines...
  14. doi request reprint Frequent hypermethylation of DBC1 in malignant lymphoproliferative neoplasms
    Kirsten Grønbaek
    Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Mod Pathol 21:632-8. 2008
    ..Our data suggest that hypermethylation of the DBC1 promoter region is a frequent event during the development of lymphoproliferative malignancies, and that DBC1 hypermethylation may serve as a marker for these cancers...
  15. ncbi request reprint Quantitative proteomics identifies Gemin5, a scaffolding protein involved in ribonucleoprotein assembly, as a novel partner for eukaryotic initiation factor 4E
    Ivo Fierro-Monti
    Department of Biochemistry and Molecular Biology, University of Southern Denmark
    J Proteome Res 5:1367-78. 2006
    ..Our results demonstrate that our quantitative proteomic strategy can be applied to the identification and quantitation of protein complex components in human cells grown under different conditions...
  16. pmc Conditional immortalization of human thyroid epithelial cells: a tool for analysis of oncogene action
    D Wynford-Thomas
    Department of Pathology, University of Wales, College of Medicine, Health Park, Cardiff, United Kingdom
    Mol Cell Biol 10:5365-77. 1990
    ....
  17. pmc Thyroid epithelial cell transformation by a retroviral vector expressing SV40 large T
    J S Burns
    Department of Pathology, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Br J Cancer 59:755-60. 1989
    ..The resulting phenotype provides a model of well-differentiated human thyroid cancer...
  18. pmc Rat embryo fibroblasts immortalized with simian virus 40 large T antigen undergo senescence upon its inactivation
    E S Gonos
    Ludwig Institute for Cancer Research, London, United Kingdom
    Mol Cell Biol 16:5127-38. 1996
    ..Inactivation of T antigen removes this block and results in senescence of the cells. Thus, these cell lines may represent a powerful system for study of the molecular basis of entry into senescence...
  19. pmc High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers
    S Fredersdorf
    Ludwig Institute for Cancer Research, Imperial College School of Medicine at St Mary s, Norfolk Place, London, W2 1PG, United Kingdom
    Proc Natl Acad Sci U S A 94:6380-5. 1997
    ..There was also an inverse correlation between the expression of p27(kip1) and the degree of tumor malignancy in human breast and colorectal cancers, indicating that p27(kip1) may be a useful prognostic marker in these cancers...
  20. pmc High level expression of differentially localized BAG-1 isoforms in some oestrogen receptor-positive human breast cancers
    M Brimmell
    Ludwig Institute for Cancer Research, Imperial College of Medicine, St Mary s Campus, London, UK
    Br J Cancer 81:1042-51. 1999
    ..These results demonstrate a close association between BAG-1 and functional ER expression and suggest BAG-1 may be useful as a therapeutic target or prognostic marker in breast cancer...
  21. ncbi request reprint Transforming growth factor-beta 1 specifically induce proteins involved in the myofibroblast contractile apparatus
    Johan Malmstrom
    Department of Molecular Sciences, AstraZeneca R and D Lund, SE 221 87 Lund, Sweden
    Mol Cell Proteomics 3:466-77. 2004
    ..These proteins accompany the induced expression of alpha-SMA and may participate in the formation of stress fibers, cell contractility, and cell spreading characterizing the myofibroblasts phenotype...
  22. ncbi request reprint Adult human mesenchymal stem cell as a target for neoplastic transformation
    Nedime Serakinci
    Department of Endocrinology, University Hospital of Odense, Denmark
    Oncogene 23:5095-8. 2004
    ..These data suggest that the adult hMSCs can be targets for neoplastic transformation and have implications for the development of novel anticancer therapeutics and for the use of hMSC in tissue engineering and transplantation protocols...
  23. ncbi request reprint Maintenance of differentiation potential of human bone marrow mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene despite [corrected] extensive proliferation
    Basem M Abdallah
    Laboratory for Molecular Endocrinology, Department of Endocrinology and Metabolism, University Hospital of Odense, Odense, Denmark
    Biochem Biophys Res Commun 326:527-38. 2005
    ....
  24. ncbi request reprint Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells
    Jorge S Burns
    Department of Endocrinology and Metabolism and Institute of Pathology, Odense University Hospital, Medical Biotechnology Center, Winsløwparken 25, DK 5000 Odense C, Denmark
    Cancer Res 65:3126-35. 2005
    ..Thus, hMSC-TERT20 clones represent cancer stem cells with hierarchical tumorigenicity, providing new models to explore the stem cell hypothesis for cancer...
  25. ncbi request reprint Blood vessels engineered from human cells
    Moustapha Kassem
    Lancet 366:891-2; author reply 892-3. 2005
  26. ncbi request reprint Adult stem cells and cancer
    M Kassem
    Cancer Res 65:9601; author reply 9601. 2005
  27. doi request reprint Sarcomas as a mise en abyme of mesenchymal stem cells: exploiting interrelationships for cell mediated anticancer therapy
    Jorge S Burns
    Laboratory of Cell Biology and Advanced Cancer Therapies, Department of Oncology, Hematology and Respiratory Disease, University Hospital of Modena and Reggio Emilia, Modena, Italy
    Cancer Lett 325:1-10. 2012
    ..Exploiting these qualities, MSC expressing modified forms of the TNF-related apoptosis-inducing ligand (Apo2L/TRAIL) are being developed to complement more conventional radiation and chemotherapy...