Graziella Bruno

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi Early life socioeconomic indicators and risk of type 1 diabetes in children and young adults
    Graziella Bruno
    Department of Medical Sciences, University of Turin, Turin, Italy
    J Pediatr 162:600-605.e1. 2013
  2. ncbi Direct costs in diabetic and non diabetic people: the population-based Turin study, Italy
    G Bruno
    Department of Internal Medicine, University of Turin, Corso Dogliotti 14, I 10126 Turin, Italy
    Nutr Metab Cardiovasc Dis 22:684-90. 2012
  3. ncbi Changes over time in the prevalence and quality of care of type 2 diabetes in Italy: the Casale Monferrato surveys, 1988 and 2000
    Graziella Bruno
    Department of Internal Medicine, University of Torino, Corso Dogliotti 14, I 10126 Torino, Italy
    Nutr Metab Cardiovasc Dis 18:39-45. 2008
  4. ncbi The impact of diabetes on prescription drug costs: the population-based Turin study
    G Bruno
    Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy
    Diabetologia 51:795-801. 2008
  5. ncbi Effect of age on the association of non-high-density-lipoprotein cholesterol and apolipoprotein B with cardiovascular mortality in a Mediterranean population with type 2 diabetes: the Casale Monferrato study
    G Bruno
    Department of Internal Medicine, University of Turin, I 10126 Turin, Italy
    Diabetologia 49:937-44. 2006
  6. ncbi C-reactive protein and 5-year survival in type 2 diabetes: the Casale Monferrato Study
    Graziella Bruno
    Department of Internal Medicine, University of Torino, Torino, Italy
    Diabetes 58:926-33. 2009
  7. ncbi Short-term mortality risk in children and young adults with type 1 diabetes: the population-based Registry of the Province of Turin, Italy
    G Bruno
    Department of Internal Medicine, University of Torino, Torino, Italy
    Nutr Metab Cardiovasc Dis 19:340-4. 2009
  8. ncbi What is the clinical usefulness of the metabolic syndrome? The Casale Monferrato study
    Graziella Bruno
    Department of Internal Medicine, University of Turin, Turin, Italy
    J Hypertens 27:2403-8. 2009
  9. ncbi The incidence of type 1 diabetes is increasing in both children and young adults in Northern Italy: 1984-2004 temporal trends
    G Bruno
    Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy
    Diabetologia 52:2531-5. 2009
  10. ncbi Age-period-cohort analysis of 1990-2003 incidence time trends of childhood diabetes in Italy: the RIDI study
    Graziella Bruno
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes 59:2281-7. 2010

Collaborators

Detail Information

Publications50

  1. ncbi Early life socioeconomic indicators and risk of type 1 diabetes in children and young adults
    Graziella Bruno
    Department of Medical Sciences, University of Turin, Turin, Italy
    J Pediatr 162:600-605.e1. 2013
    ....
  2. ncbi Direct costs in diabetic and non diabetic people: the population-based Turin study, Italy
    G Bruno
    Department of Internal Medicine, University of Turin, Corso Dogliotti 14, I 10126 Turin, Italy
    Nutr Metab Cardiovasc Dis 22:684-90. 2012
    ..We compared direct costs of diabetic and non diabetic people covered by the Italian National Health System, focusing on the influence of age, sex, type of diabetes and treatment...
  3. ncbi Changes over time in the prevalence and quality of care of type 2 diabetes in Italy: the Casale Monferrato surveys, 1988 and 2000
    Graziella Bruno
    Department of Internal Medicine, University of Torino, Corso Dogliotti 14, I 10126 Torino, Italy
    Nutr Metab Cardiovasc Dis 18:39-45. 2008
    ..In this study we assessed the prevalence of diagnosed type 2 diabetes and the quality of care during the period 1988-2000 in an Italian population...
  4. ncbi The impact of diabetes on prescription drug costs: the population-based Turin study
    G Bruno
    Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy
    Diabetologia 51:795-801. 2008
    ..The aim of our study was to compare prescription drug costs in diabetic and non-diabetic individuals in a large population-based Italian cohort covered by the National Health System...
  5. ncbi Effect of age on the association of non-high-density-lipoprotein cholesterol and apolipoprotein B with cardiovascular mortality in a Mediterranean population with type 2 diabetes: the Casale Monferrato study
    G Bruno
    Department of Internal Medicine, University of Turin, I 10126 Turin, Italy
    Diabetologia 49:937-44. 2006
    ..The aim of this population-based study was to compare the association of non-HDL-cholesterol, ApoB and the ApoB:ApoA-I ratio with cardiovascular mortality in people with type 2 diabetes...
  6. ncbi C-reactive protein and 5-year survival in type 2 diabetes: the Casale Monferrato Study
    Graziella Bruno
    Department of Internal Medicine, University of Torino, Torino, Italy
    Diabetes 58:926-33. 2009
    ....
  7. ncbi Short-term mortality risk in children and young adults with type 1 diabetes: the population-based Registry of the Province of Turin, Italy
    G Bruno
    Department of Internal Medicine, University of Torino, Torino, Italy
    Nutr Metab Cardiovasc Dis 19:340-4. 2009
    ..The quality of diabetes care should be improved to prevent early deaths...
  8. ncbi What is the clinical usefulness of the metabolic syndrome? The Casale Monferrato study
    Graziella Bruno
    Department of Internal Medicine, University of Turin, Turin, Italy
    J Hypertens 27:2403-8. 2009
    ..Data on the clinical usefulness of the metabolic syndrome with respect to cardiovascular risk are not conclusive. We have assessed this issue in a large population-based cohort of diabetic and nondiabetic people in Southern Europe...
  9. ncbi The incidence of type 1 diabetes is increasing in both children and young adults in Northern Italy: 1984-2004 temporal trends
    G Bruno
    Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy
    Diabetologia 52:2531-5. 2009
    ..We aimed to test this hypothesis by assessing trends in incidence rates in the period 1984-2004 in children and young adults in Northern Italy...
  10. ncbi Age-period-cohort analysis of 1990-2003 incidence time trends of childhood diabetes in Italy: the RIDI study
    Graziella Bruno
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes 59:2281-7. 2010
    ..To investigate age-period-cohort effects on the temporal trend of type 1 diabetes in children age 0-14 years in Italian registries...
  11. ncbi Epidemiology and costs of diabetes
    G Bruno
    Department of Internal Medicine, University of Turin, Turin, Italy
    Transplant Proc 43:327-9. 2011
    ..Because the prevalences of both type 1 and type 2 diabetes are increasing worldwide, they will produce a profound impact on overall health care costs...
  12. ncbi Estimated glomerular filtration rate, albuminuria and mortality in type 2 diabetes: the Casale Monferrato study
    G Bruno
    Department of Internal Medicine, University of Torino, Corso Dogliotti 14, I 10126 Torino, Italy
    Diabetologia 50:941-8. 2007
    ..We assessed to what extent a reduction in eGFR in people with type 2 diabetes predicts 11-year all-cause and cardiovascular mortality, independently of AER and other cardiovascular risk factors...
  13. ncbi Fasting plasma C-peptide and micro- and macrovascular complications in a large clinic-based cohort of type 1 diabetic patients
    Francesco Panero
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes Care 32:301-5. 2009
    ..Our aim was to retrospectively evaluate the association of fasting plasma C-peptide values with micro- and macrovascular complications...
  14. ncbi Incidence of type 1 and type 2 diabetes in adults aged 30-49 years: the population-based registry in the province of Turin, Italy
    Graziella Bruno
    Department of Internal Medicine, University of Turin corso Dogliotti 14, I 10126 Turin, Italy
    Diabetes Care 28:2613-9. 2005
    ..Incidence of type 1 diabetes is considered to be low in adults, but no study has been performed in Mediterranean countries...
  15. ncbi Incidence and risk factors of prolonged QTc interval in type 1 diabetes: the EURODIAB Prospective Complications Study
    Sara Giunti
    Department of Internal Medicine, University of Torino, I 10126 Torino, Italy
    Diabetes Care 30:2057-63. 2007
    ..As part of the EURODIAB Prospective Complication Study, we have assessed the 7-year incidence and risk factors of prolonged QTc in people with type 1 diabetes...
  16. ncbi Metabolic syndrome as a predictor of all-cause and cardiovascular mortality in type 2 diabetes: the Casale Monferrato Study
    Graziella Bruno
    Department of Internal Medicine, University of Turin, Corso Dogliotti 14, I 10126 Turin, Italy
    Diabetes Care 27:2689-94. 2004
    ....
  17. ncbi Uric acid is not an independent predictor of cardiovascular mortality in type 2 diabetes: a population-based study
    F Panero
    Department of Internal Medicine, University of Torino, Italy
    Atherosclerosis 221:183-8. 2012
    ..Although some studies have suggested that uric acid is a risk factor for mortality, this relationship is still uncertain in people with type 2 diabetes...
  18. ncbi Severe hypoglycemia and cardiovascular disease incidence in type 1 diabetes: the EURODIAB Prospective Complications Study
    Gabriella Gruden
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes Care 35:1598-604. 2012
    ....
  19. ncbi Low incidence of end-stage renal disease and chronic renal failure in type 2 diabetes: a 10-year prospective study
    Graziella Bruno
    Department of Internal Medicine, Turin University, Torino, Italy
    Diabetes Care 26:2353-8. 2003
    ..To provide such data, a population-based cohort of type 2 diabetic patients was identified in Casale Monferrato, Italy, and prospectively examined from 1991 to 2001...
  20. ncbi Residual beta-cell function and male/female ratio are higher in incident young adults than in children: the registry of type 1 diabetes of the province of Turin, Italy, 1984-2000
    Graziella Bruno
    Department of Internal Medicine, University of Turin, Corso Dogliotti 14, I 10126 Turin, Italy
    Diabetes Care 28:312-7. 2005
    ..The hypothesis of age-dependent variations in epidemiologic and clinical features at onset of type 1 diabetes has been assessed in the registry of the province of Turin, Italy...
  21. ncbi Anti-heat shock protein 27 antibody levels and diabetes complications in the EURODIAB study
    Davina Burt
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes Care 32:1269-71. 2009
    ..To assess whether serum anti-heat shock protein 27 (HSP27) antibody levels are associated with micro- and macrovascular complications of type 1 diabetes...
  22. ncbi Serum heat shock protein 27 and diabetes complications in the EURODIAB prospective complications study: a novel circulating marker for diabetic neuropathy
    Gabriella Gruden
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes 57:1966-70. 2008
    ..We investigated whether sHSP27 levels were associated with micro- and macrovascular complications in type 1 diabetic patients...
  23. ncbi QTc interval prolongation is independently associated with severe hypoglycemic attacks in type 1 diabetes from the EURODIAB IDDM complications study
    Gabriella Gruden
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes Care 35:125-7. 2012
    ..Our aim was to assess whether severe hypoglycemic attacks were cross-sectionally associated with abnormalities of the QTc interval in type 1 diabetic patients...
  24. ncbi Progression to overt nephropathy in type 2 diabetes: the Casale Monferrato Study
    Graziella Bruno
    Department of Internal Medicine, Turin University, Turin, Italy
    Diabetes Care 26:2150-5. 2003
    ....
  25. ncbi Electrocardiographic left ventricular hypertrophy in type 1 diabetes: prevalence and relation to coronary heart disease and cardiovascular risk factors: the Eurodiab IDDM Complications Study
    Sara Giunti
    Department of Internal Medicine, University of Turin, 14, C.so A.M. Dogliotti, I-10126, Torino, Italy
    Diabetes Care 28:2255-7. 2005
  26. ncbi Socio-economic differences in the prevalence of diabetes in Italy: the population-based Turin study
    Roberto Gnavi
    Epidemiology Unit, ASL 5, Piedmont Region, Grugliasco, Turin, Italy
    Nutr Metab Cardiovasc Dis 18:678-82. 2008
    ..The aim of this study is to assess socio-economic differences in the prevalence of diabetes in this large Italian population-based cohort...
  27. ncbi NH2-terminal probrain natriuretic peptide is associated with diabetes complications in the EURODIAB Prospective Complications Study: the role of tumor necrosis factor-α
    Gabriella Gruden
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes Care 35:1931-6. 2012
    ..We investigated whether serum NT-proBNP levels were associated with micro- and macrovascular disease in type 1 diabetic subjects...
  28. ncbi Increased QT interval dispersion predicts 15-year cardiovascular mortality in type 2 diabetic subjects: the population-based Casale Monferrato Study
    Sara Giunti
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes Care 35:581-3. 2012
    ..To evaluate the predictive role of increased corrected QT (QTc) and QT interval dispersion (QTd) on all-cause and cardiovascular mortality in a large, unselected type 2 diabetic population...
  29. ncbi Fibrinogen and AER are major independent predictors of 11-year cardiovascular mortality in type 2 diabetes: the Casale Monferrato Study
    G Bruno
    Department of Internal Medicine, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy
    Diabetologia 48:427-34. 2005
    ....
  30. ncbi Protective role of cannabinoid receptor type 2 in a mouse model of diabetic nephropathy
    Federica Barutta
    Diabetic Nephropathy Laboratory, Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes 60:2386-96. 2011
    ..The cannabinoid receptor type 2 (CB2) has protective effects in chronic degenerative diseases. Our aim was to assess the potential relevance of the CB2 receptor in both human and experimental diabetic nephropathy (DN)...
  31. ncbi Younger age at onset and sex predict celiac disease in children and adolescents with type 1 diabetes: an Italian multicenter study
    Franco Cerutti
    Dipartimento di Scienze Pediatriche e dell Adolescenza, Universita di Torino, Piazza Polonia 94, I 10126 Turin, Italy
    Diabetes Care 27:1294-8. 2004
    ..To estimate the prevalence of biopsy-confirmed celiac disease in Italian children and adolescents with type 1 diabetes and to assess whether age at onset of type 1 diabetes is independently associated with diagnosis of celiac disease...
  32. ncbi Hyperfibrinogenemia and metabolic syndrome in type 2 diabetes: a population-based study
    G Bruno
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabetes Metab Res Rev 17:124-30. 2001
    ....
  33. ncbi Sex-differences in prevalence of electrocardiographic left ventricular hypertrophy in Type 2 diabetes: the Casale Monferrato Study
    G Bruno
    Department of Internal Medicine, University of Turin, Turin, Italy
    Diabet Med 21:823-8. 2004
    ..Screening for ECG-LVH in diabetic subjects is therefore recommended, particularly in diabetic women...
  34. ncbi Circulating anti-Hsp70 levels in nascent metabolic syndrome: the Casale Monferrato Study
    Gabriella Gruden
    Department of Medical Sciences, University of Turin, Turin, Italy
    Cell Stress Chaperones 18:353-7. 2013
    ..In conclusion, our results show that serum anti-Hsp70 antibody levels are independently associated with nascent MetS...
  35. ncbi Prevalence of increased QT interval duration and dispersion in type 2 diabetic patients and its relationship with coronary heart disease: a population-based cohort
    M Veglio
    Evangelico Valdese Hospital, Torino, Italy
    J Intern Med 251:317-24. 2002
    ..To evaluate the prevalence of prolonged QT interval and dispersion in a population-based cohort of type 2 diabetic patients and their relationship with clinical and metabolic variables...
  36. ncbi ANTI-HSP60 and ANTI-HSP70 antibody levels and micro/ macrovascular complications in type 1 diabetes: the EURODIAB Study
    G Gruden
    Department of Internal Medicine, University of Turin, Italy
    J Intern Med 266:527-36. 2009
    ..Therefore, we investigated whether anti-HSP60 and anti-HSP70 antibody levels were associated with micro- and macrovascular complications in type 1 diabetic patients...
  37. ncbi Anti-CD38 autoantibodies: characterisation in new-onset type I diabetes and latent autoimmune diabetes of the adult (LADA) and comparison with other islet autoantibodies
    R Mallone
    Department of Internal Medicine, University of Torino, Italy
    Diabetologia 45:1667-77. 2002
    ..Whether these aAbs are also found in new-onset Type I diabetes and in Latent Autoimmune Diabetes in Adults (LADA) is not known, as is their relationship with conventional islet aAbs...
  38. ncbi Increasing trend of type I diabetes in children and young adults in the province of Turin (Italy). Analysis of age, period and birth cohort effects from 1984 to 1996
    G Bruno
    Department of Internal Medicine, University of Turin, Italy
    Diabetologia 44:22-5. 2001
    ..We found that the incidence of diabetes increased in the 0 to 14 age group and also in the older age group of 15 to 29 years and that the age-period models were not statistically significantly better than the age-cohort models...
  39. ncbi Serum heat shock protein 27 levels in patients with hepatocellular carcinoma
    Gabriella Gruden
    Department of Medical Science, University of Turin, C so AM Dogliotti 14, 10126 Turin, Italy
    Cell Stress Chaperones 18:235-41. 2013
    ..5 pg/ml) for differentiating patients with HCC from those with HCC-free chronic liver disease were 70 and 73 %, respectively. In conclusion, sHsp27 levels are enhanced in patients with HCC and may represent a candidate biomarker of HCC...
  40. ncbi Data sources and validity of epidemiological studies on diabetes
    G Bruno
    Department of Internal Medicine, University of Torino, Torino, Italy
    Diabetes Nutr Metab 16:189-91. 2003
  41. ncbi Apolipoprotein E polymorphism and stroke subtypes in an Italian cohort
    P Cerrato
    Department of Neuroscience, University of Turin, Turin, Italy
    Cerebrovasc Dis 20:264-9. 2005
    ..The aims of this study were: (1) to compare ApoE genotype and allele frequencies in Italian cases with ICVD and in healthy control subjects and (2) to compare ApoE allele frequencies among ischemic stroke subtypes...
  42. ncbi Higher lipoprotein (a) levels in atherothrombotic than lacunar ischemic cerebrovascular disease
    P Cerrato
    Department of Neuroscience, University of Turin, Torino, Italy
    Neurology 58:653-5. 2002
    ..This suggests that lipoprotein (a) promotes large vessel atheromatosis rather than small vessel arteriolosclerosis and favors thrombosis on atheromatous plaques by suppressing local fibrinolysis...
  43. ncbi Diabetes incidence in 0- to 14-year age-group in Italy: a 10-year prospective study
    Flavia Carle
    Department of Pediatrics, Polytechnic University of Marche Via Corridoni, 11 I-60123 Ancona, Italy
    Diabetes Care 27:2790-6. 2004
    ..However, the rates are evenly increasing both in the mainland and Sardegna, suggesting that similar environmental factors are operating over populations that have different genetic backgrounds...
  44. ncbi Re: "Detecting small-area similarities in the epidemiology of childhood acute lymphoblastic leukemia and diabetes mellitus, type 1: a Bayesian approach"
    Lorenzo Richiardi
    Am J Epidemiol 162:1132-3. 2005
  45. ncbi Prevalence of type 1 diabetes-related autoantibodies in adults with celiac disease
    Graziella Bruno
    Diabetes Care 26:1644-5. 2003
  46. ncbi The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment
    Emanuela Martinuzzi
    INSERM U580, Paris, France
    Diabetes 57:1312-20. 2008
    ..The predominant T-cell specificities change over time, but whether similar shifts also occur after clinical diagnosis and insulin treatment in type 1 diabetic patients is unknown...
  47. ncbi CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes
    Roberto Mallone
    INSERM U580, Hopital Necker, 161 rue de Sevres, 75743 Paris Cedex 15, France
    Diabetes 56:613-21. 2007
    ..Combination of CD8+ T-cell measurements with immune intervention strategies may open new avenues toward type 1 diabetes prediction and prevention...
  48. ncbi [The Piedmont Diabetes Register: opportunities and limits for epidemiological purposes]
    Roberto Gnavi
    Servizio regionale di Epidemiologia ASL 5, Regione Piemonte
    Epidemiol Prev 30:59-64. 2006
    ..The PDR is therefore not representative of the entire population of persons with diabetes in Piedmont Region...
  49. ncbi Immunization of HLA class I transgenic mice identifies autoantigenic epitopes eliciting dominant responses in type 1 diabetes patients
    Philippe Blancou
    Immuno Endocrinology Unité Mixte de Recherche 707, Institut National de la Recherche Agronomique Ecole Nationale Vétérinaire de Nantes Université, Nantes, France
    J Immunol 178:7458-66. 2007
    ..Among these, GAD(114-123), GAD(536-545) and IA-2(805-813) were recognized by 53%, 25%, and 42% of T1D patients, respectively...
  50. ncbi Variations of the perforin gene in patients with type 1 diabetes
    Elisabetta Orilieri
    Interdisciplinary Research Center of Autoimmune Diseases and Department of Medical Sciences, A Avogadro University of Eastern Piedmont, Novara, Italy
    Diabetes 57:1078-83. 2008
    ..The aim of this work was to investigate the role of PRF1 variations in type 1 diabetes...