Nicoletta Brunello

Summary

Affiliation: University of Modena and Reggio Emilia
Country: Italy

Publications

  1. ncbi request reprint Cellular mechanisms and second messengers: relevance to the psychopharmacology of bipolar disorders
    Nicoletta Brunello
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41100 Modena, Italy
    Int J Neuropsychopharmacol 6:181-9. 2003
  2. ncbi request reprint Acetylsalicylic acid accelerates the antidepressant effect of fluoxetine in the chronic escape deficit model of depression
    Nicoletta Brunello
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Italy
    Int Clin Psychopharmacol 21:219-25. 2006
  3. ncbi request reprint The role of noradrenaline and selective noradrenaline reuptake inhibition in depression
    N Brunello
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Eur Neuropsychopharmacol 12:461-75. 2002
  4. ncbi request reprint Posttraumatic stress disorder: diagnosis and epidemiology, comorbidity and social consequences, biology and treatment
    N Brunello
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Neuropsychobiology 43:150-62. 2001
  5. ncbi request reprint Noradrenaline in mood and anxiety disorders: basic and clinical studies
    Nicoletta Brunello
    Center of Neuropharmacology, Intsitute of Pharmacological Science, University of Milan, Italy
    Int Clin Psychopharmacol 18:191-202. 2003
  6. doi request reprint Central effects of a local inflammation in three commonly used mouse strains with a different anxious phenotype
    Cristina Benatti
    Department of Biomedical Sciences, University of Modena and Reggio Emilia Via Campi 287, 41125 Modena, Italy
    Behav Brain Res 224:23-34. 2011
  7. doi request reprint Constitutive and LPS-regulated expression of interleukin-18 receptor beta variants in the mouse brain
    Silvia Alboni
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Italy
    Brain Behav Immun 25:483-93. 2011
  8. doi request reprint Time-dependent effects of escitalopram on brain derived neurotrophic factor (BDNF) and neuroplasticity related targets in the central nervous system of rats
    Silvia Alboni
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Eur J Pharmacol 643:180-7. 2010
  9. doi request reprint Stress induces altered CRE/CREB pathway activity and BDNF expression in the hippocampus of glucocorticoid receptor-impaired mice
    Silvia Alboni
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena, Italy
    Neuropharmacology 60:1337-46. 2011
  10. doi request reprint Early neonatal inflammation affects adult pain reactivity and anxiety related traits in mice: genetic background counts
    Cristina Benatti
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy
    Int J Dev Neurosci 27:661-8. 2009

Detail Information

Publications27

  1. ncbi request reprint Cellular mechanisms and second messengers: relevance to the psychopharmacology of bipolar disorders
    Nicoletta Brunello
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41100 Modena, Italy
    Int J Neuropsychopharmacol 6:181-9. 2003
    ....
  2. ncbi request reprint Acetylsalicylic acid accelerates the antidepressant effect of fluoxetine in the chronic escape deficit model of depression
    Nicoletta Brunello
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Italy
    Int Clin Psychopharmacol 21:219-25. 2006
    ..These results, together with clinical data from preliminary results, suggest that ASA might accelerate the onset of action of selective serotonin reuptake inhibitor antidepressants...
  3. ncbi request reprint The role of noradrenaline and selective noradrenaline reuptake inhibition in depression
    N Brunello
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Eur Neuropsychopharmacol 12:461-75. 2002
    ..This review presents key data from the literature that support a role for noradrenaline in depression taking into account neurophysiology, psychopharmacology and clinical trial data...
  4. ncbi request reprint Posttraumatic stress disorder: diagnosis and epidemiology, comorbidity and social consequences, biology and treatment
    N Brunello
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Neuropsychobiology 43:150-62. 2001
    ..Several cognitive-behavioral and psychosocial treatments have also been reported to be efficacious and could be considered when treating PTSD patients...
  5. ncbi request reprint Noradrenaline in mood and anxiety disorders: basic and clinical studies
    Nicoletta Brunello
    Center of Neuropharmacology, Intsitute of Pharmacological Science, University of Milan, Italy
    Int Clin Psychopharmacol 18:191-202. 2003
    ....
  6. doi request reprint Central effects of a local inflammation in three commonly used mouse strains with a different anxious phenotype
    Cristina Benatti
    Department of Biomedical Sciences, University of Modena and Reggio Emilia Via Campi 287, 41125 Modena, Italy
    Behav Brain Res 224:23-34. 2011
    ..CFA led to a general decrease in central gene expression of the evaluated targets especially in CD1 mice, while BDNF hypothalamic downregulation stands out as a common effect of CFA in all three strains evaluated...
  7. doi request reprint Constitutive and LPS-regulated expression of interleukin-18 receptor beta variants in the mouse brain
    Silvia Alboni
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Italy
    Brain Behav Immun 25:483-93. 2011
    ..Our data highlight the considerable complexity of the IL-18 regulation activity in the mouse brain and further support an important central role for IL-18...
  8. doi request reprint Time-dependent effects of escitalopram on brain derived neurotrophic factor (BDNF) and neuroplasticity related targets in the central nervous system of rats
    Silvia Alboni
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Eur J Pharmacol 643:180-7. 2010
    ..Even if further experiments with different antidepressant strategies will be needed, our data suggest that escitalopram efficacy may be mediated by early and late effects on synaptic plasticity in selective brain areas...
  9. doi request reprint Stress induces altered CRE/CREB pathway activity and BDNF expression in the hippocampus of glucocorticoid receptor-impaired mice
    Silvia Alboni
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41125 Modena, Italy
    Neuropharmacology 60:1337-46. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  10. doi request reprint Early neonatal inflammation affects adult pain reactivity and anxiety related traits in mice: genetic background counts
    Cristina Benatti
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, 41100 Modena, Italy
    Int J Dev Neurosci 27:661-8. 2009
    ....
  11. ncbi request reprint Chronic treatment with desipramine and fluoxetine modulate BDNF, CaMKKalpha and CaMKKbeta mRNA levels in the hippocampus of transgenic mice expressing antisense RNA against the glucocorticoid receptor
    Jonathan Vinet
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Modena e Reggio Emilia, Via Campi, 183, 41100 Modena, Italy
    Neuropharmacology 47:1062-9. 2004
    ..These data are discussed in view of interactions existing between CaMK pathway and GR-mediated gene transcription...
  12. doi request reprint Transcriptional profiles underlying vulnerability and resilience in rats exposed to an acute unavoidable stress
    Cristina Benatti
    Department of Biomedical Sciences University of Modena and Reggio Emilia, Modena, Italy
    J Neurosci Res 90:2103-15. 2012
    ....
  13. doi request reprint Chronic treatment with the selective NOP receptor antagonist [Nphe 1, Arg 14, Lys 15]N/OFQ-NH 2 (UFP-101) reverses the behavioural and biochemical effects of unpredictable chronic mild stress in rats
    Giovanni Vitale
    Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, 41100, Modena, Italy
    Psychopharmacology (Berl) 207:173-89. 2009
    ..The present study was designed to assess the antidepressant effects of UFP-101, a selective nociceptin/orphanin FQ peptide (NOP) receptor antagonist, in a validated animal model of depression: the chronic mild stress (CMS)...
  14. doi request reprint N-acetyl-cysteine prevents toxic oxidative effects induced by IFN-α in human neurons
    Silvia Alboni
    Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Int J Neuropsychopharmacol 16:1849-65. 2013
    ..We suggest that NAC, already tested for the treatment of psychiatric disorders, may be useful to prevent IFN-α-induced central side-effects in a safe and effective way. ..
  15. pmc Mapping of the full length and the truncated interleukin-18 receptor alpha in the mouse brain
    Silvia Alboni
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    J Neuroimmunol 214:43-54. 2009
    ..These data suggest that IL-18 may modulate neuronal functions and that its action may be regulated through expression of a decoy receptor...
  16. ncbi request reprint Mood stabilizers: protecting the mood...protecting the brain
    N Brunello
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41100 Modena, Italy
    J Affect Disord 79:S15-20. 2004
    ..Thus, the mood stabilizers may act to restore the balance among aberrant signalling pathways in specific areas of the brain and prevent degeneration...
  17. ncbi request reprint Social phobia: diagnosis and epidemiology, neurobiology and pharmacology, comorbidity and treatment
    N Brunello
    Centre of Neuropharmacology, Institute of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milan, Italy
    J Affect Disord 60:61-74. 2000
    ..Many now regard SSRIs as the drugs of choice in social phobia because of their effectiveness and because they avoid the problems of treatment with benzodiazepines or classical MAOIs...
  18. ncbi request reprint Cloning of mouse Ca2+/calmodulin-dependent protein kinase kinase beta (CaMKKbeta) and characterization of CaMKKbeta and CaMKKalpha distribution in the adult mouse brain
    Jonathan Vinet
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Modena e Reggio Emilia, Via Campi 183, 41100 Modena, Italy
    Brain Res Mol Brain Res 111:216-21. 2003
    ..43% homology with the rat CaMKKbeta. Both the alpha and beta isoforms were widely distributed throughout the adult mouse brain. Additionally, all peripheral tissues examined displayed CaMKK alpha and beta expression...
  19. ncbi request reprint Effect of reboxetine treatment on brain cAMP- and calcium/calmodulin-dependent protein kinases
    S Mori
    Center of Neuropharmacology, Institute of Pharmacological Sciences, University of Milan, Milan, Italy
    Neuropharmacology 40:448-56. 2001
    ..An increase in the calcium/calmodulin-dependent phosphorylation of presynaptic substrates was also detected. These findings showed that reboxetine modulates post-receptor signal transduction systems in rat brain...
  20. ncbi request reprint Age-related changes in rat serotonergic and adrenergic systems and in receptor responsiveness to subchronic desipramine treatment
    N Brunello
    Center of Neuropharmacology, University of Milano, Italy
    Pharmacol Toxicol 63:150-5. 1988
    ....
  21. pmc Cognitive deficits and changes in gene expression of NMDA receptors after prenatal methylmercury exposure
    Mario Baraldi
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41100 Modena, Italy
    Environ Health Perspect 110:855-8. 2002
    ..The data suggest that the behavioral abnormalities of MMC-exposed rats might be ascribed to a neurotoxic effect of the metal that alters the gene expression of a specific NMDA receptor subunit in the hippocampus...
  22. ncbi request reprint Depression and sleep disorders: clinical relevance, economic burden and pharmacological treatment
    N Brunello
    Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Italy
    Neuropsychobiology 42:107-19. 2000
    ..The participants' consensus on some of the main topics is presented with the hope that this discussion and analysis will contribute to productive research in this important field...
  23. ncbi request reprint Second messenger-regulated protein kinases in the brain: their functional role and the action of antidepressant drugs
    M Popoli
    Center of Neuropharmacology, Institute of Pharmacological Sciences, University of Milan, Italy
    J Neurochem 74:21-33. 2000
    ..The changes in protein phosphorylation induced by long-term antidepressant treatment may contribute to explain the therapeutic action of antidepressants and suggest new strategies of pharmacological intervention...
  24. ncbi request reprint Dysthymia: clinical picture, extent of overlap with chronic fatigue syndrome, neuropharmacological considerations, and new therapeutic vistas
    N Brunello
    Center of Neuropharmacology, Institute of Pharmacological Sciences, University of Milan, Italy
    J Affect Disord 52:275-90. 1999
    ..At a more practical level, we raise the possibility that a subgroup within the chronic fatigue group represents a variant of dysthymia...
  25. ncbi request reprint Serine/threonine kinases as molecular targets of antidepressants: implications for pharmacological treatment and pathophysiology of affective disorders
    M Popoli
    Center of Neuropharmacology, Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133, Milano, Italy
    Pharmacol Ther 89:149-70. 2001
    ..The molecular consequences of protein kinase activation may account for some of the alterations in neural function induced by antidepressants, and may suggest novel possible strategies of pharmacological intervention...
  26. ncbi request reprint Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: a pilot open-label study
    Julien Mendlewicz
    Department of Psychiatry, Erasme Hospital, Free University of Brussels, Belgium
    Int Clin Psychopharmacol 21:227-31. 2006
    ..Potential physiological and biochemical mechanisms may involve an anti-inflammatory and/or neurotrophic effect...
  27. ncbi request reprint Altered regulation of CREB by chronic antidepressant administration in the brain of transgenic mice with impaired glucocorticoid receptor function
    Joan M C Blom
    Department of Psychology, Universita Vita Salute San Raffaele, Via Olgettina 58, Milan, Italy
    Neuropsychopharmacology 26:605-14. 2002
    ..Our findings suggest that life-long central glucocorticoid receptor dysfunction results in an altered sensitivity with respect to the effects of antidepressants on the expression of CREB...