Vincenzo Bronte

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi Regulation of immune responses by L-arginine metabolism
    Vincenzo Bronte
    Cancer Center of Veneto Region, Department of Oncological and Surgical Sciences, Padua University, Via Gattamelata 64, Padua, Italy
    Nat Rev Immunol 5:641-54. 2005
  2. ncbi Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Semin Cancer Biol 16:53-65. 2006
  3. ncbi Leukocyte infiltration in cancer creates an unfavorable environment for antitumor immune responses: a novel target for therapeutic intervention
    Vincenzo Bronte
    Istituto Oncologico Veneto, Department of Oncology and Surgical Sciences, Oncology Section, Padua University, Padua, Italy
    Immunol Invest 35:327-57. 2006
  4. ncbi IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice
    Vincenzo Bronte
    Department of Oncology and Surgical Sciences, University of Padua, Padua, Italy
    J Immunol 170:270-8. 2003
  5. ncbi L-arginine metabolism in myeloid cells controls T-lymphocyte functions
    Vincenzo Bronte
    Department of Oncology and Surgical Sciences, Via Gattamelata 64, 35128, Padua, Italy
    Trends Immunol 24:302-6. 2003
  6. doi Suppressive influences in the immune response to cancer
    Vincenzo Bronte
    Istituto Oncologico Veneto, Fondazione IRCCS, Padova, Italy
    J Immunother 32:1-11. 2009
  7. ncbi Effective genetic vaccination with a widely shared endogenous retroviral tumor antigen requires CD40 stimulation during tumor rejection phase
    Vincenzo Bronte
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    J Immunol 171:6396-405. 2003
  8. ncbi Myeloid-derived suppressor cells in inflammation: uncovering cell subsets with enhanced immunosuppressive functions
    Vincenzo Bronte
    Istituto Oncologico Veneto and Venetian Institute for Molecular Medicine, 35128 Padova, Italy
    Eur J Immunol 39:2670-2. 2009
  9. pmc Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
    Giovanna Gallina
    Istituto Oncologico Veneto, Padua, Italy
    J Clin Invest 116:2777-90. 2006
  10. doi Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF
    Luigi Dolcetti
    Istituto Oncologico Veneto, Padova, Italy
    Eur J Immunol 40:22-35. 2010

Detail Information

Publications53

  1. ncbi Regulation of immune responses by L-arginine metabolism
    Vincenzo Bronte
    Cancer Center of Veneto Region, Department of Oncological and Surgical Sciences, Padua University, Via Gattamelata 64, Padua, Italy
    Nat Rev Immunol 5:641-54. 2005
    ..This Review article focuses on the relevance of L-arginine metabolism by myeloid cells for immunity under physiological and pathological conditions...
  2. ncbi Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    Semin Cancer Biol 16:53-65. 2006
    ..The present article summarizes recent findings on the interaction between developing cancers and these recently described "myeloid suppressor cells"...
  3. ncbi Leukocyte infiltration in cancer creates an unfavorable environment for antitumor immune responses: a novel target for therapeutic intervention
    Vincenzo Bronte
    Istituto Oncologico Veneto, Department of Oncology and Surgical Sciences, Oncology Section, Padua University, Padua, Italy
    Immunol Invest 35:327-57. 2006
    ..On the basis of the recent awareness about tumor promotion and immune deregulation by immune/inflammatory cells, novel anti-cancer strategies can be exploited...
  4. ncbi IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice
    Vincenzo Bronte
    Department of Oncology and Surgical Sciences, University of Padua, Padua, Italy
    J Immunol 170:270-8. 2003
    ....
  5. ncbi L-arginine metabolism in myeloid cells controls T-lymphocyte functions
    Vincenzo Bronte
    Department of Oncology and Surgical Sciences, Via Gattamelata 64, 35128, Padua, Italy
    Trends Immunol 24:302-6. 2003
    ..This Opinion is the second in a series on the regulation of the immune system by metabolic pathways...
  6. doi Suppressive influences in the immune response to cancer
    Vincenzo Bronte
    Istituto Oncologico Veneto, Fondazione IRCCS, Padova, Italy
    J Immunother 32:1-11. 2009
    ..In this review, the best characterized mechanisms that allow cancer cells to evade immune surveillance are overviewed and the most debated controversies constellating this complex field are highlighted...
  7. ncbi Effective genetic vaccination with a widely shared endogenous retroviral tumor antigen requires CD40 stimulation during tumor rejection phase
    Vincenzo Bronte
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    J Immunol 171:6396-405. 2003
    ....
  8. ncbi Myeloid-derived suppressor cells in inflammation: uncovering cell subsets with enhanced immunosuppressive functions
    Vincenzo Bronte
    Istituto Oncologico Veneto and Venetian Institute for Molecular Medicine, 35128 Padova, Italy
    Eur J Immunol 39:2670-2. 2009
    ..Moreover, this paper contributes to defining the cell subsets that possess immunoregulatory properties within the broad population of CD11b(+)Gr-1(+) cells, often altogether referred to as MDSC...
  9. pmc Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
    Giovanna Gallina
    Istituto Oncologico Veneto, Padua, Italy
    J Clin Invest 116:2777-90. 2006
    ..Moreover, our data show how the inflammatory response elicited by tumors had detrimental effects on the adaptive immune system and suggest novel approaches for the treatment of tumor-induced immune dysfunctions...
  10. doi Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF
    Luigi Dolcetti
    Istituto Oncologico Veneto, Padova, Italy
    Eur J Immunol 40:22-35. 2010
    ..These data unveil a hierarchy of immunoregulatory activity among MDSC subsets that is controlled by tumor-released GM-CSF...
  11. doi Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells
    Ilaria Marigo
    Department of Oncology and Surgical Sciences, Padova University, Padova, Italy, and Venetian Institute for Molecular Medicine, Padova, Italy
    Immunol Rev 222:162-79. 2008
    ..Based on observations of MDSCs, we present a time-structured and topologically consistent idea of tumor-dependent tolerance progression in tumor-bearing hosts...
  12. doi Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor
    Ilaria Marigo
    Department of Oncology and Surgical Sciences, University of Padua, 35128 Padua, Italy
    Immunity 32:790-802. 2010
    ....
  13. doi Myeloid-derived suppressor cell heterogeneity and subset definition
    Elisa Peranzoni
    Department of Oncology and Surgical Sciences, University of Padua, Padua, Italy
    Curr Opin Immunol 22:238-44. 2010
    ..Moreover, this dichotomy holds true for human MDSCs. We attempt here to summarize conflicting findings in the field and provide some possible, unifying explanations...
  14. ncbi Myeloid suppressor lines inhibit T cell responses by an NO-dependent mechanism
    Alessandra Mazzoni
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Department of Oncology and Surgical Sciences, Oncology Section, Azienda Ospedaliera, Padova, Italy
    J Immunol 168:689-95. 2002
    ..The distinctive capacity of MSC to generate suppressive signals when encountering activated T cells defines a specialized subset of myeloid cells that most likely serve a regulatory function during times of heightened immune activity...
  15. ncbi Role of arginine metabolism in immunity and immunopathology
    Elisa Peranzoni
    Department of Oncology and Surgical Sciences, Padova University, Via Gattamelata 64, 35128, Padova, Italy
    Immunobiology 212:795-812. 2007
    ....
  16. doi Immune tolerance to tumor antigens occurs in a specialized environment of the spleen
    Stefano Ugel
    Department of Surgery, Oncology and Gastroenterology, University of Padua, 35128 Padua, Italy
    Cell Rep 2:628-39. 2012
    ..CCL2 serum levels in cancer patients are directly related to the accumulation of immature myeloid cells and are predictive for overall survival in patients who develop a multipeptide response to cancer vaccines...
  17. ncbi Derangement of immune responses by myeloid suppressor cells
    Paolo Serafini
    Department of Oncology and Surgical Sciences, Oncology Section, Azienda Ospedaliera, Via Gattamelata 64, 35128, Padova, Italy
    Cancer Immunol Immunother 53:64-72. 2004
    ..This review examines recent findings on the nature, properties, and mechanisms of action of these myeloid suppressor cells (MSCs)...
  18. doi Myeloid-derived suppressor cell role in tumor-related inflammation
    Luigi Dolcetti
    Department of Oncology and Surgical Sciences, Via Gattamelata 64, 35128 Padova, Italy
    Cancer Lett 267:216-25. 2008
    ..Understanding how the inflammatory milieu favours tumor escape through the accumulation of MDSCs could be very useful to improve the efficacy of cancer immunotherapy...
  19. doi Autoimmune B-cell lymphopenia after successful adoptive therapy with telomerase-specific T lymphocytes
    Stefano Ugel
    Department of Oncology and Surgical Sciences, Padova, Italy
    Blood 115:1374-84. 2010
    ..These results indicate B cells as an in vivo target of TERT-specific cytotoxic T lymphocytes during successful immunotherapy...
  20. pmc In vivo administration of artificial antigen-presenting cells activates low-avidity T cells for treatment of cancer
    Stefano Ugel
    Department of Oncology, Oncology Section, Istituto di Ricovero e Cura a Carattere Scientifico, Padua, Italy
    Cancer Res 69:9376-84. 2009
    ..Therefore, in vivo aAPC administration represents a potentially novel approach to improve cancer immunotherapy...
  21. pmc A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells
    Samantha Solito
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padova, Italy
    Blood 118:2254-65. 2011
    ....
  22. doi miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis
    Nada Sonda
    Department of Surgery, Oncology and Gastroenterology, Oncology and Immunology Section, University of Padua, 35128 Padua, Italy
    Immunity 38:1236-49. 2013
    ..By modulating a specific miR in bone marrow precursors, we thus demonstrated the feasibility of altering tumor-induced macrophage differentiation as a potent tool to improve the efficacy of cancer immunotherapy...
  23. doi Myeloid cell diversification and complexity: an old concept with new turns in oncology
    Mariacristina Chioda
    Istituto Oncologico Veneto, IRCCS, Via Gattamelata 64, 35128 Padova, Italy
    Cancer Metastasis Rev 30:27-43. 2011
    ..In this manuscript, we review the recent literature on tumour-conditioned myeloid subsets that assist tumour growth, both in mice and humans...
  24. pmc Differential expression of constitutive and inducible proteasome subunits in human monocyte-derived DC differentiated in the presence of IFN-alpha or IL-4
    Valeria Tosello
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padova, Italy
    Eur J Immunol 39:56-66. 2009
    ..In general, these data show the impact of cytokines on APM component expression and hence the Ag-processing ability of DC...
  25. pmc Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination
    Carmela De Santo
    Department of Oncology and Surgical Sciences, Oncology Section, Padua University, 35128 Padua, Italy
    Proc Natl Acad Sci U S A 102:4185-90. 2005
    ..Because cancer vaccines and NO aspirin are currently being investigated in independent phase I/II clinical trials, these findings offer a rationale to combine these treatments in subjects with advanced neoplastic diseases...
  26. doi Antigen specificity of immune suppression by myeloid-derived suppressor cells
    Samantha Solito
    Department of Oncological and Surgical Sciences, Via Gattamelata, 64 35128 Padova, Italy
    J Leukoc Biol 90:31-6. 2011
    ....
  27. pmc Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers
    Vincenzo Bronte
    Department of Oncology and Surgical Sciences, University of Padova, 35100 Padova, Italy
    J Exp Med 201:1257-68. 2005
    ..These results identify a novel and dominant mechanism by which cancers induce immunosuppression in situ and suggest novel strategies for tumor immunotherapy...
  28. doi IL4Ralpha+ myeloid-derived suppressor cell expansion in cancer patients
    Susanna Mandruzzato
    Department of Oncology and Surgical Sciences, Oncology Section, University of Padova, Padova, Italy
    J Immunol 182:6562-8. 2009
    ..Similarly to mouse MDSC, IL4Ralpha is up-regulated in both myeloid populations but its presence correlates with an immunosuppressive phenotype only when mononuclear cells, but not granulocytes, of tumor-bearing patients are considered...
  29. pmc Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
    Barbara Molon
    Istituto Oncologico Veneto, Istituti di Ricovero e Cura a Carattere Scientifico IRCCS Venetian Oncological Institute, 35128 Padua, Italy
    J Exp Med 208:1949-62. 2011
    ..Our results unveil an unexpected mechanism of tumor evasion and introduce new avenues for cancer immunotherapy...
  30. doi Transcription factors in myeloid-derived suppressor cell recruitment and function
    Nada Sonda
    Istituto Oncologico Veneto, IRCCS, Via Gattamelata 64, 35128 Padova, Italy
    Curr Opin Immunol 23:279-85. 2011
    ..Understanding the molecular networks regulating the phenotypic and functional determination of MDSCs is essential to identify potential therapeutic targets to revert immune deregulation in cancer...
  31. doi Therapeutic targeting of myeloid-derived suppressor cells
    Stefano Ugel
    Department of Oncology and Surgical Science, Via Gattamelata 64, 35128 Padova, Italy
    Curr Opin Pharmacol 9:470-81. 2009
    ..Pharmacological inhibition of MDSC suppressive pathways is a promising strategy to overcome disease-induced immune defects, which might be a key step in enhancing the effectiveness of immune-based therapies...
  32. doi Measurement of myeloid cell immune suppressive activity
    Luigi Dolcetti
    Istituto Oncologico Veneto, IRCCS, Padua, Italy
    Curr Protoc Immunol . 2010
    ....
  33. ncbi Part I: Vaccines for solid tumours
    Simone Mocellin
    Department of Oncological and Surgical Sciences, University of Padova, Italy
    Lancet Oncol 5:681-9. 2004
    ....
  34. ncbi Nitric oxide, a double edged sword in cancer biology: searching for therapeutic opportunities
    Simone Mocellin
    Department of Oncological and Surgical Sciences, School of Medicine, University of Padova, Padova, Italy
    Med Res Rev 27:317-52. 2007
    ....
  35. doi Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150
    Margherita Ghisi
    Department of Oncology and Surgical Sciences, University of Padova, Padova, Italy
    Blood 117:7053-62. 2011
    ..Overall, these findings suggest that control of the Notch pathway through miR-150 may have an important impact on T-cell development and physiology...
  36. ncbi Small noncoding RNAs in cells transformed by human T-cell leukemia virus type 1: a role for a tRNA fragment as a primer for reverse transcriptase
    Katia Ruggero
    Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy
    J Virol 88:3612-22. 2014
    ..These findings suggest that tRF-3019 may play an important role in priming HTLV-1 reverse transcription and could thus represent a novel target to control HTLV-1 infection...
  37. ncbi Myeloid-derived suppressor cell heterogeneity in human cancers
    Samantha Solito
    Department of Surgery, Oncology and Gastroenterology, Oncology and Immunology Section, University of Padova, Padova, Italy
    Ann N Y Acad Sci 1319:47-65. 2014
    ..In this review, we describe the differences between MDSC populations expanded within different tumor contexts and evaluate the prognostic significance of MDSC expansion in peripheral blood and within tumor masses of neoplastic patients. ..
  38. doi Modulation of human T-cell functions by reactive nitrogen species
    Tihana Kasic
    Venetian Institute of Molecular Medicine, Padua, Italy
    Eur J Immunol 41:1843-9. 2011
    ..Since substantial protein nitration, a hallmark of nitrative stress, was observed in various human cancers, intratumoral generation of RNS might represent a relevant mechanism for tumor evasion from immune surveillance...
  39. ncbi Metabolic mechanisms of cancer-induced inhibition of immune responses
    Antonella Viola
    Venetian Institute of Molecular Medicine, Padua, Italy Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Semin Cancer Biol 17:309-16. 2007
    ..The knowledge of these complex and partially interconnected metabolic pathways is offering new targets for an integrated pharmacological approach aiming at freeing tumor-specific T lymphocytes from the latches of cancer influence...
  40. doi Interferon-alpha counteracts the angiogenic switch and reduces tumor cell proliferation in a spontaneous model of prostatic cancer
    Luca Persano
    Oncology Section, Department of Oncology and Surgical Sciences, University of Padova, Padova I 35128, Italy
    Carcinogenesis 30:851-60. 2009
    ..Since the angiogenic switch also marks progression of human prostatic cancer, these results highlight the potential of angiogenesis inhibitors for the development of chemoprevention strategies in high-risk individuals...
  41. doi Myeloid-derived suppressor cells in cancer patients: a clinical perspective
    Alberto J Montero
    Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA
    J Immunother 35:107-15. 2012
    ..Finally, we examine the strategies designed to modulate MDSCs in cancer patients, which might represent an innovative approach to enhance the effectiveness of immune-based therapies...
  42. doi Role of microRNAs in HTLV-1 infection and transformation
    Katia Ruggero
    Department of Oncology and Surgical Sciences, University of Padova, Via Gattamelata 64, Padova, Italy
    Mol Aspects Med 31:367-82. 2010
    ..Observations along with regarding the expression of tRNA-derived small regulatory RNAs in HTLV-1-infected cells are presented...
  43. pmc The transcriptional response in human umbilical vein endothelial cells exposed to insulin: a dynamic gene expression approach
    Barbara Di Camillo
    Information Engineering Department, University of Padova, Padova, Italy
    PLoS ONE 5:e14390. 2010
    ....
  44. ncbi Methotrexate for immunosuppression in life-supporting pig-to-cynomolgus monkey renal xenotransplantation
    Emanuele Cozzi
    Direzione Sanitaria, Padua General Hospital, Padua, Italy
    Xenotransplantation 10:587-95. 2003
    ..We conclude that MTX is scarcely effective as an immunosuppressant, be it for induction or maintenance, in pig-to-cynomolgus monkey renal xenotransplantation...
  45. ncbi High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21231, USA
    Cancer Res 64:6337-43. 2004
    ....
  46. pmc Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function
    Paolo Serafini
    Sidney Kimmel Comprehensive Cancer Center, Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, Baltimore, MD 21231, USA
    J Exp Med 203:2691-702. 2006
    ..In light of the recent data that enzymes mediating MDSC-dependent immunosuppression in mice are active also in humans, these findings demonstrate a potentially novel use of PDE5 inhibitors as adjuncts to tumor-specific immune therapy...
  47. ncbi Toward the identification of a tolerogenic signature in IDO-competent dendritic cells
    Ciriana Orabona
    Section of Pharmacology, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy
    Blood 107:2846-54. 2006
    ..Overall, these studies reveal the occurrence of a simple and evolutionarily conserved code in the control of tolerance by an ancestral metabolic enzyme...
  48. ncbi Cancer immunotherapy based on killing of Salmonella-infected tumor cells
    Francesca Avogadri
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Cancer Res 65:3920-7. 2005
    ..This is effective in retarding the growth of untreated established distant tumors and in protecting the mice from subsequent tumor challenges...
  49. ncbi Cancer vaccines: pessimism in check
    Simone Mocellin
    Nat Med 10:1278-9; author reply 1279-80. 2004
  50. ncbi CpG-Oligodeoxynucleotides activate tyrosinase-related protein 2-specific T lymphocytes but do not lead to a protective tumor-specific memory response
    Lucia Sfondrini
    Molecular Targeting Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, Via Venezian 1, 20133, Milan, Italy
    Cancer Immunol Immunother 53:697-704. 2004
    ....
  51. ncbi Therapeutic effectiveness of recombinant cancer vaccines is associated with a prevalent T-cell receptor alpha usage by melanoma-specific CD8+ T lymphocytes
    Raffaele De Palma
    Department of Clinical and Experimental Medicine II, University of Naples, Naples, Italy
    Cancer Res 64:8068-76. 2004
    ..Successful therapy correlated strictly with the skewing of the T-cell receptor repertoire of tetramer-sorted, TRP-2-specific CD8(+) T lymphocytes, which showed a preferential alpha chain usage with a common CDR3 region...
  52. pmc The terminology issue for myeloid-derived suppressor cells
    Dmitry I Gabrilovich
    Cancer Res 67:425; author reply 426. 2007
  53. pmc Altered macrophage differentiation and immune dysfunction in tumor development
    Antonio Sica
    Istituto Clinico Humanitas, Instituto di Ricovero e Cura a Carattere Scientifico IRCCS, Rozzano, Italy
    J Clin Invest 117:1155-66. 2007
    ....