M L Brandi

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. pmc The negative feedback-loop between the oncomir Mir-24-1 and menin modulates the Men1 tumorigenesis by mimicking the "Knudson's second hit"
    Ettore Luzi
    Metabolic Bone Unit, Department of Internal Medicine, University of Florence, Florence, Italy
    PLoS ONE 7:e39767. 2012
  2. pmc Targeted approaches in the treatment of osteoporosis: differential mechanism of action of denosumab and clinical utility
    Loredana Cavalli
    Unit of Mineral and Bone Metabolism Diseases, Department of Internal Medicine, Traumatologic Orthopedic Center, Florence, Italy
    Ther Clin Risk Manag 8:253-66. 2012
  3. pmc Primary hyperparathyroidism in multiple endocrine neoplasia type 1: when to perform surgery?
    Francesca Giusti
    Bone and Mineral Metabolism Unit, Department of Internal Medicine, University Hospital of Careggi, Florence, Italy
    Clinics (Sao Paulo) 67:141-4. 2012
  4. pmc MicroRNA Role in Thyroid Cancer Development
    Francesca Marini
    Unit of Metabolic Bone Diseases, Department of Internal Medicine, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Thyroid Res 2011:407123. 2011
  5. pmc Pharmacogenetics of osteoporosis
    Francesca Marini
    Metabolic Bone Unit, Department of Internal Medicine, University of Florence Viale Pieraccini 6, 50139 Florence Italy
    F1000 Biol Rep 2:63. 2010
  6. pmc Biphosphonates-related osteonecrosis of the jaw: Clinical and physiopathological considerations
    Alberto Borgioli
    Department of Odontostomatology, Dental School
    Ther Clin Risk Manag 5:217-27. 2009
  7. pmc Thyroid cancer: current molecular perspectives
    Francesca Giusti
    Regional Centre for Hereditary Endocrine Tumors, Unit of Metabolic Bone Diseases, Department of Internal Medicine, University of Florence, Viale Morgagni 85, 50135 Florence, Italy
    J Oncol 2010:351679. 2010
  8. pmc The burden of breast cancer in Italy: mastectomies and quadrantectomies performed between 2001 and 2008 based on nationwide hospital discharge records
    Prisco Piscitelli
    Department of Internal Medicine, University of Florence, Viale Pieraccini 18, Florence 50139, Italy
    J Exp Clin Cancer Res 31:96. 2012
  9. doi request reprint When the government actively faces the burden of osteoporosis: the Italian experience
    Maria Luisa Brandi
    Department of Internal Medicine, University of Florence, Florence, Italy
    Arch Osteoporos 7:21-4. 2012
  10. doi request reprint Drugs for bone healing
    Maria Luisa Brandi
    University of Florence, Department of Surgery and Translational Medicine, Mineral and Bone Metabolic Diseases Unit, Largo Palagi, 1, 50100 Florence, Italy
    Expert Opin Investig Drugs 21:1169-76. 2012

Detail Information

Publications108 found, 100 shown here

  1. pmc The negative feedback-loop between the oncomir Mir-24-1 and menin modulates the Men1 tumorigenesis by mimicking the "Knudson's second hit"
    Ettore Luzi
    Metabolic Bone Unit, Department of Internal Medicine, University of Florence, Florence, Italy
    PLoS ONE 7:e39767. 2012
    ..The functional significance of this regulatory mechanism in MEN1 tumorigenesis is also the basis for opening future developments of RNA antagomir(s)-based strategies in the in vivo control of tumorigenesis in MEN1 carriers...
  2. pmc Targeted approaches in the treatment of osteoporosis: differential mechanism of action of denosumab and clinical utility
    Loredana Cavalli
    Unit of Mineral and Bone Metabolism Diseases, Department of Internal Medicine, Traumatologic Orthopedic Center, Florence, Italy
    Ther Clin Risk Manag 8:253-66. 2012
    ..The drug was approved for postmenopausal osteoporosis in women at increased risk of fracture and for the treatment of bone loss associated with androgen deprivation therapy in men with prostate cancer...
  3. pmc Primary hyperparathyroidism in multiple endocrine neoplasia type 1: when to perform surgery?
    Francesca Giusti
    Bone and Mineral Metabolism Unit, Department of Internal Medicine, University Hospital of Careggi, Florence, Italy
    Clinics (Sao Paulo) 67:141-4. 2012
    ..Surgery is the recommended treatment. The goal of this short review is to discuss the timing of surgery in patients when primary hyperparathyroidism is associated with multiple endocrine neoplasia type 1...
  4. pmc MicroRNA Role in Thyroid Cancer Development
    Francesca Marini
    Unit of Metabolic Bone Diseases, Department of Internal Medicine, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    J Thyroid Res 2011:407123. 2011
    ..In this paper we reviewed the available data on miRNA deregulation in different thyroid tumors and describe the putative role of miRNA in thyroid cancer development...
  5. pmc Pharmacogenetics of osteoporosis
    Francesca Marini
    Metabolic Bone Unit, Department of Internal Medicine, University of Florence Viale Pieraccini 6, 50139 Florence Italy
    F1000 Biol Rep 2:63. 2010
    ..This review will provide an overview of the pharmacogenetics of osteoporosis, focusing on the major recent advances in the past two years...
  6. pmc Biphosphonates-related osteonecrosis of the jaw: Clinical and physiopathological considerations
    Alberto Borgioli
    Department of Odontostomatology, Dental School
    Ther Clin Risk Manag 5:217-27. 2009
    ..When pharmacologic treatments with antibiotics and local antiseptics are not able to control the development of BRON-J's complications, the clinicians should perform radical surgical treatments such as the resection of the bone involved...
  7. pmc Thyroid cancer: current molecular perspectives
    Francesca Giusti
    Regional Centre for Hereditary Endocrine Tumors, Unit of Metabolic Bone Diseases, Department of Internal Medicine, University of Florence, Viale Morgagni 85, 50135 Florence, Italy
    J Oncol 2010:351679. 2010
    ..This review will briefly report on the histological features and the new entity represented by thyroid microcarcinoma and will focus on both environmental and genetic aspects associated with the occurrence of thyroid cancer...
  8. pmc The burden of breast cancer in Italy: mastectomies and quadrantectomies performed between 2001 and 2008 based on nationwide hospital discharge records
    Prisco Piscitelli
    Department of Internal Medicine, University of Florence, Viale Pieraccini 18, Florence 50139, Italy
    J Exp Clin Cancer Res 31:96. 2012
    ..We explored the potentials of Nationwide hospital discharge records (NHDRs) to capture incident breast cancer cases in Italy...
  9. doi request reprint When the government actively faces the burden of osteoporosis: the Italian experience
    Maria Luisa Brandi
    Department of Internal Medicine, University of Florence, Florence, Italy
    Arch Osteoporos 7:21-4. 2012
    ..THE FUTURE OF OSTEOPOROSIS IN ITALY: We hope that the example of Italy would serve as an inspiration to those countries where the history of osteoporosis only recently began...
  10. doi request reprint Drugs for bone healing
    Maria Luisa Brandi
    University of Florence, Department of Surgery and Translational Medicine, Mineral and Bone Metabolic Diseases Unit, Largo Palagi, 1, 50100 Florence, Italy
    Expert Opin Investig Drugs 21:1169-76. 2012
    ..Fracture healing complications negatively affect the patient's quality of life, even more when fractures occur in the elderly osteoporotic patients...
  11. pmc Age-specific effects of estrogen receptors' polymorphisms on the bone traits in healthy fertile women: the BONTURNO study
    Francesco Massart
    Department of Internal Medicine, University of Florence, Florence, Italy
    Reprod Biol Endocrinol 7:32. 2009
    ..Common variants in the genes encoding for estrogen receptor alpha (ESR1) and beta (ESR2) are proposed as candidates for influencing bone phenotypes at the population level...
  12. pmc Multiple endocrine neoplasia type 2
    Francesca Marini
    Regional Center for Hereditary Endocrine Tumors, Department of Internal Medicine, University of Florence, Florence, Italy
    Orphanet J Rare Dis 1:45. 2006
    ..At present, surgical treatment offers the only chance of cure and therefore, early clinical and genetic detection and prophylactic surgery in subjects at risk are the main therapeutic goal...
  13. pmc Multiple endocrine neoplasia type 1
    Francesca Marini
    Regional Center for Hereditary Endocrine Tumours, Department of Internal Medicine, University of Florence, Florence, Italy
    Orphanet J Rare Dis 1:38. 2006
    ....
  14. pmc The incidence of hip, forearm, humeral, ankle, and vertebral fragility fractures in Italy: results from a 3-year multicenter study
    Umberto Tarantino
    Division of Orthopaedics and Traumatology, Tor Vergata Foundation University Hospital, University of Rome, Tor Vergata, Viale Oxford 81, Rome, 00133, Italy
    Arthritis Res Ther 12:R226. 2010
    ..We aimed to assess the incidence and hospitalization rate of hip and "minor" fragility fractures in the Italian population...
  15. pmc Segregation of a M404V mutation of the p62/sequestosome 1 (p62/SQSTM1) gene with polyostotic Paget's disease of bone in an Italian family
    Alberto Falchetti
    Department of Internal Medicine, University of Florence, Florence, Italy
    Arthritis Res Ther 7:R1289-95. 2005
    ....
  16. ncbi request reprint Management of post-menopausal osteoporosis: something new on the horizon?
    M L Brandi
    Department of Internal Medicine, University of Florence, Florence, Italy
    J Endocrinol Invest 26:170-3. 2003
  17. ncbi request reprint Current treatment approaches for Paget's Disease of Bone
    Maria Luisa Brandi
    Bone and Mineral Metabolic Unit, Department of Internal Medicine and Careggi Hospital, University of Florence, Florence, Italy
    Discov Med 10:209-12. 2010
    ..This article will focus on the present status and future pharmacological developments in PDB...
  18. doi request reprint Sustained vertebral antifracture efficacy of oral anti-osteoporotic therapies in postmenopausal osteoporosis
    M L Brandi
    University of Florence Medical School, Florence, Italy
    Curr Med Res Opin 26:2553-63. 2010
    ..Vertebral fractures are common in women with postmenopausal osteoporosis, a chronic condition requiring long-term treatment with anti-osteoporotic treatments. Therefore, it is important to assess sustainability of antifracture efficacy...
  19. ncbi request reprint Genetics of hypoparathyroidism and pseudohypoparathyroidism
    M L Brandi
    Unit of Bone and Mineral Metabolism, Department of Internal Medicine, University of Florence, Medical School, Viale Pieraccini, 6 50139 Florence, Italy
    J Endocrinol Invest 34:27-34. 2011
    ..The present article reviews the various disorders related to both hypoparathyroid and pseudohypoparathyroid conditions, with a detailed report of the recent discoveries in term of the genetics of these syndromes...
  20. doi request reprint Microarchitecture, the key to bone quality
    Maria Luisa Brandi
    Department of Internal Medicine, University of Florence, Florence, Italy
    Rheumatology (Oxford) 48:iv3-8. 2009
    ....
  21. ncbi request reprint Genetics of primary hyperparathyroidism
    Maria Luisa Brandi
    Department of Internal Medicine, University of Florence, Florence, Italy
    Urol Int 72:11-6. 2004
    ..Such mechanisms could, in the near future, become an ideal target for new therapeutic strategies of primary hyperparathyroidism...
  22. ncbi request reprint An overview of osteoporosis: from genetics to clinics
    Maria Luisa Brandi
    Endocrinology and Metabolic Disorders, Universita degli Studi di Firenze, and Metabolic Bone Disease Department, A O U Careggi, Firenze, Italy
    Aging Clin Exp Res 23:3-5. 2011
    ..In the future, pharmacogenomics will optimize therapy response by customization on the basis of genotype, improving efficacy, and limiting the onset of side effects...
  23. ncbi request reprint What is the relationship between Paget's disease of bone and hyperparathyroidism?
    Maria Luisa Brandi
    Department of Internal Medicine and DeGene Spin off, University of Florence, Florence, Italy
    J Bone Miner Res 21:P69-74. 2006
  24. ncbi request reprint Guidelines for diagnosis and therapy of MEN type 1 and type 2
    M L Brandi
    Department of Internal Medicine, University of Florence, 50139 Florence, Italy
    J Clin Endocrinol Metab 86:5658-71. 2001
    ....
  25. ncbi request reprint FokI polymorphism of the vitamin D receptor gene correlates with parameters of bone mass and turnover in a female population of the Italian island of Lampedusa
    A Falchetti
    Department of Internal Medicine, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Calcif Tissue Int 80:15-20. 2007
    ..Our data suggest that FokI VDR polymorphism may contribute to the determination of bone mass and turnover in both pre- and postmenopausal women in this geographically isolated population...
  26. pmc Relationship of volumetric bone mineral density and structural parameters with ERalpha gene polymorphisms
    C Cepollaro
    Department of Internal Medicine, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy
    Calcif Tissue Int 80:307-15. 2007
    ..These results show a relationship between the presence of the P allele and higher values of CtTh in male subjects, indicating for ERalpha a role in the control of tibial bone geometry...
  27. ncbi request reprint Microencapsulation of human parathyroid cells: an "in vitro" study
    L Picariello
    Surgery Unit, Department of Clinical Physiopathology, University of Florence, 50139 Florence, Italy
    J Surg Res 96:81-9. 2001
    ..CONCLUSIONS: These findings represent a crucial step toward the construction of functional bioartificial parathyroid organoids for the treatment of hypoparathyroidism in humans...
  28. ncbi request reprint Polymorphism of the aromatase gene in postmenopausal Italian women: distribution and correlation with bone mass and fracture risk
    L Masi
    Department of Clinical Physiopathology, University of Florence, Italy
    J Clin Endocrinol Metab 86:2263-9. 2001
    ..1 (95% confidence interval, 1.19-13.87). In conclusion, the aromatase gene can be one of the several genes potentially involved in the maintenance of bone mass and in the regulation of bone mass loss...
  29. ncbi request reprint Association of the estrogen receptor alpha gene polymorphisms with sporadic Alzheimer's disease
    M L Brandi
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Biochem Biophys Res Commun 265:335-8. 1999
    ..The ERalpha gene appears to interact with the APOE-epsilon4 genotype in determining AD susceptibility...
  30. doi request reprint Ribozyme-mediated compensatory induction of menin-oncosuppressor function in primary fibroblasts from MEN1 patients
    E Luzi
    Department of Internal Medicine, Metabolic Bone Unit, Regional Center for Hereditary Endocrine Tumors, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
    Cancer Gene Ther 17:814-25. 2010
    ..These findings contribute to the understanding of tumorigenesis in MEN1, offering the basis for the development of RNA-based therapies in MEN1 gene mutation carriers...
  31. ncbi request reprint A comparison of methods for the analysis of low abundance proteins in desmoid tumor cells
    L Picariello
    Department of Clinical Physiopathology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Anal Biochem 354:205-12. 2006
    ..The use of a specific and reliable assessment method becomes fundamental in the evaluation of the presence and modulation of proteins which are important but weakly expressed in these rare tumors...
  32. ncbi request reprint Genetics of osteoporosis: role of steroid hormone receptor gene polymorphisms
    L Gennari
    Department of Internal Medicine, University of Florence, Viale Pieraccini 6, 50135 Florence, Italy
    J Steroid Biochem Mol Biol 81:1-24. 2002
    ....
  33. ncbi request reprint Genetics and pharmacogenetics of osteoporosis
    S Carbonell Sala
    Department of Internal Medicine, University of Florence, and DEGENE Srl, Florence, Italy
    J Endocrinol Invest 28:2-7. 2005
    ..Genetic polymorphisms are also starting to be used to predict drug response. A new era of pharmacogenetics represents an interesting prospective to identify the potential individuals to receive customised treatments...
  34. doi request reprint Effect of inhaled glucocorticoids and beta(2) agonists on vertebral fracture risk in COPD patients: the EOLO study
    S Gonnelli
    Department of Internal Medicine, Endocrine Metabolic Science, and Biochemistry, University of Siena, Policlinico Le Scotte, Viale Bracci 2, 53100 Siena, Italy
    Calcif Tissue Int 87:137-43. 2010
    ..28, and OR = 1.40, CI 1.06-1.82, respectively). In conclusion, in COPD patients high doses of inhaled GCs, but not beta(2) agonists, are associated with an increased risk of vertebral fractures and a reduction of QUS at the calcaneus...
  35. pmc Genetic markers of osteoarticular disorders: facts and hopes
    M L Brandi
    Department of Medicine, University of Florence, Viale Morgagni 85, 50135 Florence, Italy
    Arthritis Res 3:270-80. 2001
    ....
  36. ncbi request reprint RFLP analysis of human chromosome 11 region q13 in multiple symmetric lipomatosis and multiple endocrine neoplasia type 1-associated lipomas
    A Morelli
    Department of Clinical Physiopathology, University of Florence, Italy
    Biochem Biophys Res Commun 207:363-8. 1995
    ..All the samples were negative for activating mutations...
  37. ncbi request reprint Binding and bioeffects of Ipriflavone on a human preosteoclastic cell line
    S Benvenuti
    Department of Clinical Physiopathology, University of Florence, School of Medicine, Italy
    Biochem Biophys Res Commun 201:1084-9. 1994
    ..These results demonstrate a direct effect of Ipriflavone and of Metabolite III on the human osteoclast precursor cell line FLG 29.1...
  38. ncbi request reprint Genotype distribution of estrogen receptor-alpha gene polymorphisms in Italian women with surgical uterine leiomyomas
    F Massart
    University of Florence, Italy
    Fertil Steril 75:567-70. 2001
    ..To explore a possible association between estrogen receptor-alpha (ER-alpha) gene polymorphisms and development of uterine leiomyomas...
  39. ncbi request reprint The importance of the unsuppressed glands in the study of intact parathyroid hormone disappearance after parathyroid adenomectomy
    F Locchi
    Department of Clinical Physiopathology, State University, Firenze, Italy
    Eur J Endocrinol 144:353-62. 2001
    ..On the contrary, we believe, as do other researchers, that they are not totally suppressed...
  40. doi request reprint Multiple endocrine neoplasia type 1 (MEN1): not only inherited endocrine tumors
    Alberto Falchetti
    Regional Centre for Hereditary Endocrine Tumors, Unit of Metabolic Bone Diseases, Department of Internal Medicine, University of Florence, Florence, Italy
    Genet Med 11:825-35. 2009
    ..The ever increrasing combination of genetic and clinical tools will allow early detection of MEN1-associated neoplasms, potentially improving clinical outcomes and quality of life for both affected patients and their relatives...
  41. doi request reprint A novel recessive mutation of fibroblast growth factor-23 in tumoral calcinosis
    L Masi
    Department of Internal Medicine, University Hospital of Florence, Florence, Italy
    J Bone Joint Surg Am 91:1190-8. 2009
    ..Mutational analysis is important for the early recognition of the disorder, for prevention of its complications, and for family screening strategies. We examined two unrelated white patients affected by tumoral calcinosis...
  42. ncbi request reprint Lessons from genes mutated in multiple endocrine neoplasia (MEN) syndromes
    A Falchetti
    Department of Internal Medicine and Clinical Physiopathology, University of Florence, Florence, Italy
    Ann Endocrinol (Paris) 66:195-205. 2005
    ....
  43. ncbi request reprint The genetic ascertainment of multiple endocrine neoplasia type 1 syndrome by ancient DNA analysis
    F Marini
    Regional Center for Hereditary Endocrine Tumours, Department of Internal Medicine, University of Florence, Florence, Italy
    J Endocrinol Invest 31:905-9. 2008
    ....
  44. ncbi request reprint Genetics of male osteoporosis
    L Gennari
    Dept. of Clinical Physiopathology, University of Florence, Italy
    Calcif Tissue Int 69:200-4. 2001
    ..These observations remain to be confirmed by other independent studies. Other candidate genes, are still awaiting mapping and identification...
  45. ncbi request reprint 2006 update on genetic determinants of osteoporosis
    S Carbonell Sala
    Department of Internal Medicine, School of Medicine, University of Florence, 50139 Florence, Italy
    J Endocrinol Invest 30:2-7. 2007
    ..This paper pretends to give a panoramic on actual genetics of osteoporosis situation, taking into account the most important recent genetic studies in the field...
  46. ncbi request reprint Catecholamines modulate growth and differentiation of human preosteoclastic cells
    U Frediani
    Department of Clinical Physiopathology, University of Florence, Italy
    Osteoporos Int 6:14-21. 1996
    ..1 cells. In differentiated FLG 29.1 cells only IL-6 release was induced by catecholamine treatment. These findings support a potential role for catecholamines in modulating osteoclast differentiation and mature osteoclast activity...
  47. ncbi request reprint TGF-beta isoform and receptor expression in giant cell tumor and giant cell lesions of bone
    A Franchi
    Department of Human Pathology and Oncology, University of Florence Medical School, Italy
    Appl Immunohistochem Mol Morphol 9:170-5. 2001
    ....
  48. ncbi request reprint Physiopathological basis of bone turnover
    L Masi
    Department of Clinical Physiopathology, University of Florence, Italy
    Q J Nucl Med 45:2-6. 2001
    ..Understanding the sequence of cellular events may be important to better know the mechanisms responsible for bone loss that occurs in age and in several pathological conditions...
  49. doi request reprint New perspectives on the definition and the management of severe osteoporosis: the patient with two or more fragility fractures
    R Nuti
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, University of Siena, 53100 Siena, Italy
    J Endocrinol Invest 32:783-8. 2009
    ..This definition does not entirely reflect the spectrum of severity of the disease that provides a variable increase in fracture risk...
  50. ncbi request reprint Bone mineral density in cystic fibrosis patients under the age of 18 years
    A S Neri
    Cystic Fibrosis Center of Tuscany, Meyer Hospital, Florence, Italy
    Minerva Pediatr 60:147-54. 2008
    ..The increase in life expectancy of cystic fibrosis (CF) patients has brought about a rise in new clinical problems in these patients, such as a decrease in bone mineral density (BMD). The cause of diminished BMD in CF is multi-factorial...
  51. ncbi request reprint A polymorphic CYP19 TTTA repeat influences aromatase activity and estrogen levels in elderly men: effects on bone metabolism
    Luigi Gennari
    Department of Internal Medicine, University of Florence, 50139 Florence, Italy
    J Clin Endocrinol Metab 89:2803-10. 2004
    ..In conclusion, differences in estrogen levels due to polymorphism at the aromatase CYP19 gene may predispose men to increased age-related bone loss and fracture risk...
  52. ncbi request reprint Is total parathyroidectomy the treatment of choice for hyperparathyroidism in multiple endocrine neoplasia type 1?
    Francesco Tonelli
    Department of Clinical Physiopathology, University of Florence, Medical SchoolFlorence, Italy
    Ann Surg 246:1075-82. 2007
    ..The aim of the present report is to describe the results obtained with total parathyroidectomy (TPTX) guided by rapid intraoperative parathyroid hormone (PTH) evaluation, followed by immediate parathyroid autograft with fresh tissue...
  53. ncbi request reprint Osteoprotegerin serum levels in Kawasaki disease: an additional potential marker in predicting children with coronary artery involvement
    Gabriele Simonini
    Department of Paediatrics, Rheumatology Unit, University of Florence, Florence, Italy
    J Rheumatol 32:2233-8. 2005
    ..We evaluated serum levels of OPG in a group of children with Kawasaki disease (KD), before immunoglobulin (IVIG) infusion and at 3-month followup...
  54. doi request reprint Pharmacogenetics of osteoporosis: future perspectives
    Francesca Marini
    Mineral and Bone Metabolism Unit, Department of Internal Medicine, University of Florence, Florence, Italy
    Calcif Tissue Int 84:337-47. 2009
    ..In this paper we review the most recent data on pharmacogenetics of osteoporosis, highlighting the presentations at the Second International Meeting on Pharmacogenetics of Osteoarticular Disorders held in Florence in April 2008...
  55. doi request reprint Estrogen receptor expression in cutaneous melanoma: a real-time reverse transcriptase-polymerase chain reaction and immunohistochemical study
    Vincenzo de Giorgi
    Department of Dermatology, University of Florence, Via della Pergola 60, 50121 Florence, Italy
    Arch Dermatol 145:30-6. 2009
    ..To evaluate estrogen receptor (ER) expression in human melanoma tissues and in the adjacent healthy skin with the aim of explaining whether the ERalpha:ERbeta expression ratio has a role in neoplastic progression...
  56. doi request reprint Genetic epidemiology of Paget's disease of bone in italy: sequestosome1/p62 gene mutational test and haplotype analysis at 5q35 in a large representative series of sporadic and familial Italian cases of Paget's disease of bone
    Alberto Falchetti
    Department of Internal Medicine, University of Florence, Florence, Italy
    Calcif Tissue Int 84:20-37. 2009
    ..This may be helpful in estimating the true rate of de novo mutations. We confirm the data on the existence of both a mutational hotspot at the UBA domain of SQSTM1/p62 and a founder effect in the PDB population...
  57. ncbi request reprint Somatostatinoma: clinico-pathological features of three cases and literature reviewed
    Gabriella Nesi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    J Gastroenterol Hepatol 23:521-6. 2008
    ..A comparison between our three cases and those in the literature provides useful insights into the clinical management of these patients. Interestingly, the jejunal somatostatinoma described here is the second case ever reported...
  58. ncbi request reprint Osteoprotegerin (OPG)/RANK-L system in juvenile idiopathic arthritis: is there a potential modulating role for OPG/RANK-L in bone injury?
    Laura Masi
    Department of Internal Medicine, University of Florence, Florence, Italy
    J Rheumatol 31:986-91. 2004
    ....
  59. ncbi request reprint Clodronate: mechanisms of action on bone remodelling and clinical use in osteometabolic disorders
    Valentina Ghinoi
    Department of Internal Medicine, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Expert Opin Pharmacother 3:1643-56. 2002
    ..However, studies that demonstrate an effect on the rate of fractures are needed before any recommendation can be made...
  60. pmc Pancreatectomy in multiple endocrine neoplasia type 1-related gastrinomas and pancreatic endocrine neoplasias
    Francesco Tonelli
    Department of Clinical Physiopathology, University of Florence, Medical School, Florence, Italy
    Ann Surg 244:61-70. 2006
    ..The aim of this study was to evaluate the results of pancreatic resection in pancreatic endocrine neoplasias (PENs) in patients affected by multiple endocrine neoplasia type 1 (MEN1) syndrome...
  61. ncbi request reprint Dynamic investigation for evaluation of calcium metabolism and parathyroid function
    F Cioppi
    Department of Internal Medicine, University of Florence, Florence, Italy
    J Endocrinol Invest 26:83-91. 2003
    ..Only in selected conditions, here briefly reviewed, dynamic tests can offer an interpretation on the pathogenetic events causing a disorder of calcium metabolism...
  62. ncbi request reprint Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women
    L Masi
    Department of Clinical Physiopathology, University of Florence, Italy
    Biochem Biophys Res Commun 245:622-6. 1998
    ..In addition, Duncan's test used to compare the genotypes showed that TT genotype has significant lower lumbar BMD in comparison with CC genotype...
  63. ncbi request reprint Serum osteopontin as a predictive marker of responsiveness to methotrexate in juvenile idiopathic arthritis
    Laura Masi
    A Meyer Children s Hospital, University of Florence, Firenze, Italy
    J Rheumatol 36:2308-13. 2009
    ..To evaluate if serum concentrations of osteopontin (OPN) at baseline in patients with juvenile idiopathic arthritis (JIA) represent a potential predictor of responsiveness to methotrexate (MTX)...
  64. doi request reprint Multiple endocrine neoplasms
    Alberto Falchetti
    Surgery Unit, Department of Clinical Physiopathology, University of Florence, 6 50139 Florence, Italy
    Best Pract Res Clin Rheumatol 22:149-63. 2008
    ..If not diagnosed precociously, MTC can be fatal. MEN1 develops after tissue inactivation of both MEN1 gene copies. Activating mutations of c-RET proto-oncogene causes MEN2...
  65. doi request reprint DNA-based test: when and why to apply it to primary hyperparathyroidism clinical phenotypes
    A Falchetti
    The Regional Centre for Hereditary Endocrine Tumors, Unit of Metabolic Bone Diseases, University Hospital of Careggi, Italy
    J Intern Med 266:69-83. 2009
    ..Some practical recommendations and suggestions concerning on how to deal when a suspect or known case of familial PHPT has to be faced conclude this manuscript...
  66. doi request reprint Validation of a food-frequency questionnaire for the assessment of calcium intake in schoolchildren aged 9-10 years
    B Pampaloni
    Department of Surgery and Translational Medicine, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy
    Calcif Tissue Int 93:23-38. 2013
    ....
  67. ncbi request reprint Updated fracture incidence rates for the Italian version of FRAX®
    P Piscitelli
    Department of Internal Medicine, University of Florence, Largo Palagi 1, 50138 Florence, Italy
    Osteoporos Int 24:859-66. 2013
    ..Mortality data and 10-year probabilities of major osteoporotic fractures were also updated. This revision will improve FRAX accuracy and reliability...
  68. doi request reprint Assessing 5-year incidence rates and determinants of osteoporotic fractures in primary care
    F Lapi
    Department of Preclinical and Clinical Pharmacology, University of Florence, Italy
    Bone 50:85-90. 2012
    ..To assess the gender and age-related 5-year incidence rates of osteoporotic fractures, and their related predictors, in a primary care setting...
  69. ncbi request reprint Surgery for gastroenteropancreatic tumours in multiple endocrine neoplasia type 1: review and personal experience
    F Tonelli
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Intern Med 257:38-49. 2005
    ..Endoscopic removal is possible for lesions growing in the mucosa-submucosa, but partial or even total gastrectomy is recommended for the small number of gastric carcinoids infiltrating the muscular layers...
  70. ncbi request reprint Molecular, biochemical and cellular biology of PTH anabolic action
    L Masi
    Department of Internal Medicine, University of Florence, Florence, Italy
    J Endocrinol Invest 28:37-40. 2005
    ..PTH (1-34) is currently being safely and effectively used in osteoporosis, and together with novel PTH derivates agent provides more tools for the clinicians in their armamentarium for the fight against osteoporosis...
  71. ncbi request reprint Growth response of colon cancer cell lines to selective estrogen receptor modulators
    Lucia Picariello
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    Anticancer Res 23:2419-24. 2003
    ..The purpose of this study was to compare the "in vitro" effects of the selective estrogen receptor modulators, tamoxifen and raloxifene, on two human colon cancer cell lines...
  72. ncbi request reprint Characterization of the functional and growth properties of long-term cell cultures established from a human somatostatinoma
    G Galli
    Department of Internal Medicine, University of Florence Medical School, Viale Pieraccini 6, 50139 Florence, Italy
    Endocr Relat Cancer 13:79-93. 2006
    ..Based on these findings, the potential of SST analogues, IFN-gamma and AZT, alone or in combination, should be further explored in the medical treatment of somatostatinoma...
  73. ncbi request reprint Estrogen metabolism in human colorectal cancer cells
    G Fiorelli
    Department of Clinical Physiopathology, University of Florence, Florence, Italy
    J Steroid Biochem Mol Biol 81:281-9. 2002
    ..In conclusion, our results clearly show that metabolism of estrogens by 17betaHSD isoenzymes is functional and modulated by external stimuli in continuous neoplastic colonic epithelial cell lines...
  74. ncbi request reprint Calcium modulates the cyclin D1 expression in a rat parathyroid cell line
    S Bianchi
    Department of Clinical Physiopathology, University of Florence, Italy
    Biochem Biophys Res Commun 204:691-700. 1994
    ..Increasing amounts of calcium in the incubation medium reduced the expression of rat cyclin D1 and D2. The effect appears to be cell-specific and probably mediated through the inhibition of mitogenic signalling pathways...
  75. ncbi request reprint Modulatory effect of farnesyl pyrophosphate synthase (FDPS) rs2297480 polymorphism on the response to long-term amino-bisphosphonate treatment in postmenopausal osteoporosis
    Francesca Marini
    Department of Internal Medicine, University of Florence, Florence, Italy
    Curr Med Res Opin 24:2609-15. 2008
    ..Polymorphisms of genes encoding enzymes of the mevalonate pathway could modulate the response to amino-bisphosphonate treatment in postmenopausal osteoporosis...
  76. ncbi request reprint Estrogen receptor alpha and beta polymorphisms: is there an association with bone mineral density, plasma lipids, and response to postmenopausal hormone therapy?
    Sandra Silvestri
    Department of Internal Medicine, School of Medicine, University of Florence, Florence, Italy
    Menopause 13:451-61. 2006
    ..In another untreated subpopulation of 443 women, genotype influence on the prevalence of vertebral fractures and on annual rate of bone loss during a mean follow-up period of 11 years was estimated...
  77. ncbi request reprint In vitro effects of oestrogens, antioestrogens and SERMs on pancreatic solid pseudopapillary neoplasm-derived primary cell culture
    Isabella Tognarini
    Department of Internal Medicine, University of Florence Medical School, Florence, Italy
    Cell Oncol 32:331-43. 2010
    ..The controversial expression of oestrogen receptors (ERs) in SPNs, provide a rationale for studying the effects of oestrogenic molecules on SPN development...
  78. ncbi request reprint Association of low bone mass with vitamin d receptor gene and calcitonin receptor gene polymorphisms in juvenile idiopathic arthritis
    Laura Masi
    Department of Pediatrics, University of Florence, Florence, Italy
    J Rheumatol 29:2225-31. 2002
    ..To compare bone density with polymorphisms in the calcitonin receptor (CTR) and vitamin D receptor (VDR) genes in 50 patients with juvenile idiopathic arthritis and 80 matched controls...
  79. ncbi request reprint Paget's disease of bone: there's more than the affected skeletal--a clinical review and suggestions for the clinical practice
    Alberto Falchetti
    Regional Center for Hereditary Endocrine Tumors, Department of Internal Medicine, University of Florence, Florence, Italy
    Curr Opin Rheumatol 22:410-23. 2010
    ..A practical suggestion for an optimal management path of Paget's disease of bone is given...
  80. ncbi request reprint Germline mutations in MEN1 and BRCA1 genes in a woman with familial multiple endocrine neoplasia type 1 and inherited breast-ovarian cancer syndromes: a case report
    Laura Papi
    Medical Genetics Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Cancer Genet Cytogenet 195:75-9. 2009
    ..We explore genetic and molecular rationales for an association between these neoplastic processes...
  81. doi request reprint A patient with MEN1-associated hyperparathyroidism, responsive to cinacalcet
    Alberto Falchetti
    University Hospital of Careggi, Florence, Italy
    Nat Clin Pract Endocrinol Metab 4:351-7. 2008
    ..MEN1 was confirmed by analysis of the MEN1 gene, which revealed a 1555insG frameshift mutation. In 2006 serum calcium and parathyroid hormone (PTH) levels were again found to be high...
  82. ncbi request reprint ERbeta is a potent inhibitor of cell proliferation in the HCT8 human colon cancer cell line through regulation of cell cycle components
    Valentina Martineti
    Department of Internal Medicine, School of Medicine, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Endocr Relat Cancer 12:455-69. 2005
    ..These findings are compatible with the hypothesis that the loss of ERbeta expression could be one of the events involved in the development or progression of colon cancer...
  83. ncbi request reprint Azidothymidine induces apoptosis and inhibits cell growth and telomerase activity of human parathyroid cancer cells in culture
    Alberto Falchetti
    Department of Internal Medicine, University of Florence, Florence, Italy
    J Bone Miner Res 20:410-8. 2005
    ..In vitro exposure of these cells to AZT correlated with inhibition of cell proliferation...
  84. ncbi request reprint Low adherence of a clinically healthy Italian population to nutritional recommendations for primary prevention of chronic diseases
    Francesco Sofi
    Department of Medical and Surgical Critical Care, Thrombosis Centre, University of Florence, Azienda Ospedaliero Universitaria Careggi, Florence, Italy
    Nutr Metab Cardiovasc Dis 16:436-44. 2006
    ..The aims of this study were to evaluate dietary habits, and to assess the adherence of the general population to the recommendations for correct nutritional behaviour...
  85. ncbi request reprint In vitro differentiation of human mesenchymal stem cells on Ti6Al4V surfaces
    Isabella Tognarini
    Department of Internal Medicine, Medical School, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Biomaterials 29:809-24. 2008
    ..In conclusion, adipose tissue is a promising autologous source of osteoblastic cells with important clinical implications for bone tissue engineering...
  86. ncbi request reprint Selective oestrogen receptor modulators in desmoid tumours
    Lucia Picariello
    Department of Clinical Physiopathology, University of Florence, Italy
    Expert Opin Investig Drugs 13:1457-68. 2004
    ..The knowledge of the molecular basis of SERM action will make the development of novel synthetic compounds with engineered tissue selectivity possible...
  87. ncbi request reprint Treatment of desmoids and mesenteric fibromatosis in familial adenomatous polyposis with raloxifene
    Francesco Tonelli
    Department of Clinical Physiopathology, University of Florence, Italy
    Tumori 89:391-6. 2003
    ..Pharmacological management of this relentless problem is favored by surgical intervention. At present, however, beneficial actions of medical therapy are not separable from undesirable side effects...
  88. ncbi request reprint Intravenous zoledronic acid in postmenopausal women with low bone mineral density
    Ian R Reid
    Department of Medicine, University of Auckland, Auckland, New Zealand
    N Engl J Med 346:653-61. 2002
    ..Gastrointestinal intolerance limits maximal dosing. Although intermittent intravenous treatments have been used, the optimal doses and dosing interval have not been systematically explored...
  89. ncbi request reprint Determinants of bone turnover markers in healthy premenopausal women
    Silvano Adami
    Rheumatology Unit, University of Verona, Ospedale di Valeggio, Valeggio, Verona, Italy
    Calcif Tissue Int 82:341-7. 2008
    ..New normative ranges for serum OC, CTX, and P1NP were identified; and our findings in general impose a redefinition of the criteria for establishing the normal ranges for BTMs...
  90. ncbi request reprint Myostatin polymorphisms and age-related sarcopenia in the Italian population
    Anna Maria Corsi
    J Am Geriatr Soc 50:1463. 2002
  91. ncbi request reprint Papillary thyroid carcinoma
    Cetta Francesco
    Am J Surg Pathol 27:1176-7. 2003
  92. pmc Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study
    Stuart H Ralston
    Rheumatic Diseases Unit, University of Edinburgh, Western General Hospital Edinburgh, Edinburgh, United Kingdom
    PLoS Med 3:e90. 2006
    ....
  93. ncbi request reprint Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes
    John P A Ioannidis
    Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
    JAMA 292:2105-14. 2004
    ..Estrogen receptor alpha (ESR1) is a candidate gene for osteoporosis, but previous studies of ESR1 polymorphisms in this field were hampered by small sample size, lack of standardization, and inconclusive results...
  94. doi request reprint Pharmacogenetics of bone treatments: the VDR and ERalpha gene story
    Francesco Massart
    Department of Pediatrics, University of Pisa, Pisa, Italy
    Pharmacogenomics 9:733-46. 2008
    ..g., VDR or ERalpha). Because of their specific ethnic distribution, VDR and ERalpha polymorphisms may be involved in reported human differences of osteoporosis treatment responses...
  95. ncbi request reprint Clonal chromosomal defects in the molecular pathogenesis of refractory hyperparathyroidism of uremia
    Yasuo Imanishi
    Center for Molecular Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 3101, USA
    J Am Soc Nephrol 13:1490-8. 2002
    ....
  96. ncbi request reprint Evidence of sexual dimorphism in relationships between estrogen receptor polymorphisms and bone mass: the Hertfordshire study
    Elaine Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, England
    J Rheumatol 32:2400-4. 2005
    ..To examine the relationship between estrogen receptor (ER) a and ss gene polymorphisms and bone mass...
  97. ncbi request reprint Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients
    Giuseppe Vezzoli
    Division of Nephrology Dialysis and Hypertension, Postgraduate School of Nephrology, Ateneo Vita e Salute, IRCCS San Raffaele Hospital, Milan, Italy
    J Am Soc Nephrol 13:2517-23. 2002
    ..Arg990Gly polymorphism could facilitate activation of CaSR and increase Ca excretion and susceptibility to idiopathic hypercalciuria...
  98. ncbi request reprint Polymorphic analysis of the matrix metalloproteinase-9 gene and susceptibility to sporadic abdominal aortic aneurysm
    Chiara Armani
    Cardiac and Thoracic Department, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Biomed Pharmacother 61:268-71. 2007
    ..We compared the results with those of 156 healthy subjects. No difference was found in the allelic distribution of either polymorphisms. We therefore found no evidence that MMP-9 is a marker of susceptibility for AAA...