Pier Carlo Braga

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint Assessment of the antioxidant activity of the SH metabolite I of erdosteine on human neutrophil oxidative bursts
    P C Braga
    Center for Respiratory Pharmacology, School of Medicine, University of Milan, Italy
    Arzneimittelforschung 50:739-46. 2000
  2. ncbi request reprint Staphylococcus aureus and Escherichia coli adhesion to human cells is reduced by sub-MICs of gemifloxacin
    P C Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Italy
    J Chemother 14:41-6. 2002
  3. ncbi request reprint Effects of gatifloxacin on phagocytosis, intracellular killing and oxidant radical production by human polymorphonuclear neutrophils
    P C Braga
    Center for Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Int J Antimicrob Agents 19:183-7. 2002
  4. ncbi request reprint Relationship between differences in 16-, 14-, and 15-membered ring macrolides and Streptococcus pyogenes resistance
    P C Braga
    Centre of Respiratory Pharmacology, Department of Pharmacology, University of Milan, Italy
    Eur J Clin Microbiol Infect Dis 21:146-8. 2002
  5. ncbi request reprint Rokitamycin: bacterial resistance to a 16-membered ring macrolide differs from that to 14- and 15-membered ring macrolides
    P C Braga
    Department of Pharmacology, School of Medicine, University of Milan, Italy
    J Chemother 14:115-31. 2002
  6. ncbi request reprint Inhibitory effects of zafirlukast on respiratory bursts of human neutrophils
    P C Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Drugs Exp Clin Res 28:133-45. 2002
  7. pmc Flow cytometric assessment of susceptibilities of Streptococcus pyogenes to erythromycin and rokitamycin
    Pier Carlo Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Antimicrob Agents Chemother 47:408-12. 2003
  8. ncbi request reprint Daptomycin morphostructural damage in Bacillus cereus visualized by atomic force microscopy
    P C Braga
    Department of Pharmacology, School of Medicine, University of Milan, Italy
    J Chemother 14:336-41. 2002
  9. ncbi request reprint Antioxidant potential of thymol determined by chemiluminescence inhibition in human neutrophils and cell-free systems
    Pier Carlo Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, IT 20129 Milan, Italy
    Pharmacology 76:61-8. 2006
  10. ncbi request reprint Human neutrophil oxidative bursts and their in vitro modulation by different N-acetylcysteine concentrations
    Luigi Allegra
    Department of Pharmacology, Institute of Respiratory Diseases, School of Medicine, University of Milan, Milan, Italy
    Arzneimittelforschung 52:669-76. 2002

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Assessment of the antioxidant activity of the SH metabolite I of erdosteine on human neutrophil oxidative bursts
    P C Braga
    Center for Respiratory Pharmacology, School of Medicine, University of Milan, Italy
    Arzneimittelforschung 50:739-46. 2000
    ..The findings indicate that the metabolite I of erdosteine has antioxidant activity which, together with the drug's mucomodifying activity, may lead to a useful antiphlogistic effect...
  2. ncbi request reprint Staphylococcus aureus and Escherichia coli adhesion to human cells is reduced by sub-MICs of gemifloxacin
    P C Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Italy
    J Chemother 14:41-6. 2002
    ..aureus were also observed, mainly from 1/2 MIC to 1/8 and 1/16 MIC. These findings are discussed in terms of dose-effect relationships and the interpolation of this pharmacodynamic data with the pharmacokinetics curve of gemifloxacin...
  3. ncbi request reprint Effects of gatifloxacin on phagocytosis, intracellular killing and oxidant radical production by human polymorphonuclear neutrophils
    P C Braga
    Center for Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Int J Antimicrob Agents 19:183-7. 2002
    ..coli strain at 1/32 MIC and in two strains at 1/16 MIC. The incubation of PMNs with sub-MICs and supra-MICs of gatifloxacin (to 32 MIC) did not affect the oxidative bursts...
  4. ncbi request reprint Relationship between differences in 16-, 14-, and 15-membered ring macrolides and Streptococcus pyogenes resistance
    P C Braga
    Centre of Respiratory Pharmacology, Department of Pharmacology, University of Milan, Italy
    Eur J Clin Microbiol Infect Dis 21:146-8. 2002
  5. ncbi request reprint Rokitamycin: bacterial resistance to a 16-membered ring macrolide differs from that to 14- and 15-membered ring macrolides
    P C Braga
    Department of Pharmacology, School of Medicine, University of Milan, Italy
    J Chemother 14:115-31. 2002
    ....
  6. ncbi request reprint Inhibitory effects of zafirlukast on respiratory bursts of human neutrophils
    P C Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Drugs Exp Clin Res 28:133-45. 2002
    ..The different behavior determined by different times of contact and different stimuli opens the way to interpretations concerning the antioxidant effect of zafirlukast...
  7. pmc Flow cytometric assessment of susceptibilities of Streptococcus pyogenes to erythromycin and rokitamycin
    Pier Carlo Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Antimicrob Agents Chemother 47:408-12. 2003
    ..pyogenes M phenotype, and of erythromycin at doses of up to 32 microg/ml, which was not...
  8. ncbi request reprint Daptomycin morphostructural damage in Bacillus cereus visualized by atomic force microscopy
    P C Braga
    Department of Pharmacology, School of Medicine, University of Milan, Italy
    J Chemother 14:336-41. 2002
    ..In addition to structural changes, the destabilization of flagella was also observed. These results support previous data suggesting that daptomycin disrupts membrane function...
  9. ncbi request reprint Antioxidant potential of thymol determined by chemiluminescence inhibition in human neutrophils and cell-free systems
    Pier Carlo Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, IT 20129 Milan, Italy
    Pharmacology 76:61-8. 2006
    ..Our findings in human neutrophils are pharmacologically relevant as they imply that thymol is a potential antioxidant and anti-inflammatory agent in human cells...
  10. ncbi request reprint Human neutrophil oxidative bursts and their in vitro modulation by different N-acetylcysteine concentrations
    Luigi Allegra
    Department of Pharmacology, Institute of Respiratory Diseases, School of Medicine, University of Milan, Milan, Italy
    Arzneimittelforschung 52:669-76. 2002
    ..The fact that no effects were seen on PMN phagocytosis and bacterial killing indicates that NAC has no negative influence on other PMN functions such as antimicrobial activity...
  11. doi request reprint Free radical scavenging activity of erdosteine metabolite I investigated by electron paramagnetic resonance spectroscopy
    Pier Carlo Braga
    Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Pharmacology 85:195-202. 2010
    ..Our findings show that the intensity of 4 different free radicals was significantly reduced in the presence of Met I, thus indicating the presence of a termination reaction between the free radicals and Met I...
  12. doi request reprint Antioxidant activity of bisabolol: inhibitory effects on chemiluminescence of human neutrophil bursts and cell-free systems
    Pier Carlo Braga
    Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Pharmacology 83:110-5. 2009
    ..These findings draw the attention to the possible medical use of bisabolol as a means of improving the antioxidant network and restoring the redox balance by antagonising oxidative stress...
  13. doi request reprint Free radical-scavenging activity of sulfurous water investigated by electron paramagnetic resonance (EPR) spectroscopy
    Pier Carlo Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Exp Lung Res 38:67-74. 2012
    ....
  14. ncbi request reprint Budesonide reduces superoxide and peroxynitrite anion chemiluminescence during human neutrophil bursts
    Pier Carlo Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Pharmacology 75:179-86. 2005
    ....
  15. ncbi request reprint Effect of butylated hydroxyanisole and some of its derivatives on human neutrophil oxidative burst: chemiluminescence evaluation
    Pier Carlo Braga
    Department of Pharmacology, School of Medicine, University of Milan, Italy
    Pharmacology 68:9-16. 2003
    ..e. free radical release and Ca(2+) overload...
  16. ncbi request reprint Inhibitory effects of metabolite I of erdosteine on the generation of nitric oxide and peroxynitrite chemiluminescence by human neutrophils
    Monica Dal Sasso
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Pharmacology 71:120-7. 2004
    ....
  17. doi request reprint Protective effect of erdosteine metabolite I against hydrogen peroxide-induced oxidative DNA-damage in lung epithelial cells
    Laura Marabini
    Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, University of Milan, Milan, Italy
    Arzneimittelforschung 61:700-6. 2011
    ..The data suggest that this compound is effective in preventing H2O2-induced oxidative stress and DNA damage in A549 cells. The underlying mechanisms involve the scavenging of intracellular reactive oxygen species (ROS)...
  18. doi request reprint Antioxidant activity of Calendula officinalis extract: inhibitory effects on chemiluminescence of human neutrophil bursts and electron paramagnetic resonance spectroscopy
    Pier Carlo Braga
    Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Pharmacology 83:348-55. 2009
    ....
  19. doi request reprint Effects of sulphurous water on human neutrophil elastase release
    Pier Carlo Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Ther Adv Respir Dis 4:333-40. 2010
    ..The aim of this study was to investigate the direct activity of such water on the release of elastase by activated human neutrophils...
  20. ncbi request reprint Anti-inflammatory activity of thymol: inhibitory effect on the release of human neutrophil elastase
    Pier Carlo Braga
    Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Pharmacology 77:130-6. 2006
    ..These two latter characteristics make thymol a molecule that can have helpful effects in controlling the inflammatory processes present in many infections...
  21. ncbi request reprint Effect of metabolite I of erdosteine on the release of human neutrophil elastase
    Pier Carlo Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Pharmacology 77:150-4. 2006
    ..By reducing elastase and oxidant radical release (two major components of the inflammatory process), Met I have clinically useful anti-inflammatory effects...
  22. doi request reprint Thermal treatment of eggplant (Solanum melongena L.) increases the antioxidant content and the inhibitory effect on human neutrophil burst
    Roberto Lo Scalzo
    CRA IAA, Agricultural Research Council, Food Technology Research Unit, via Venezian 26, Milan, Italy
    J Agric Food Chem 58:3371-9. 2010
    ..00 microg/mL. These results showed that the thermal treatment commonly used before consumption can increase the content and biological activity of antioxidant compounds of eggplants...
  23. ncbi request reprint A combination of budesonide and the SH-metabolite I of erdosteine acts synergistically in reducing chemiluminescence during human neutrophil respiratory burst
    Monica Dal Sasso
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Pharmacology 74:127-34. 2005
    ..Our findings indicate a synergistic antioxidant effect when BUD and Met I are given together, which is of interest for counteracting the airway phlogosis involved in many respiratory diseases...
  24. ncbi request reprint Antioxidant effect of sulphurous thermal water on human neutrophil bursts: chemiluminescence evaluation
    Pier Carlo Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Respiration 75:193-201. 2008
    ....
  25. doi request reprint Thymol inhibits Candida albicans biofilm formation and mature biofilm
    Pier Carlo Braga
    Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, Milan, Italy
    Int J Antimicrob Agents 31:472-7. 2008
    ..As biofilm is a multifactorial phenomenon, the multiple mechanisms of thymol (terpenes) could act on different steps in the evolution of mature biofilm...
  26. ncbi request reprint Visual evaluation of binding to mucosal cells of a medical device against the common cold
    Pier Carlo Braga
    Department of Pharmacology, School of Medicine, Center of Respiratory Pharmacology, University of Milan, Milan, Italy
    Drug Dev Ind Pharm 34:459-64. 2008
    ....
  27. doi request reprint Inhibitory activity of thymol on native and mature Gardnerella vaginalis biofilms: in vitro study
    Pier Carlo Braga
    Department of Pharmacology, School of Medicine, University of Milan, Italy
    Arzneimittelforschung 60:675-81. 2010
    ..Nomarski interference contrast and fluorescence microscopy visually confirmed these findings. As biofilm is a multi-factorial phenomenon, the multiple mechanisms of thymol may act on different steps in the evolution of mature biofilm...
  28. ncbi request reprint Effects of sub-minimum inhibitory concentrations of gatifloxacin on the inhibition of Staphylococcus aureus and Escherichia coli adherence
    Pier Carlo Braga
    Center of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Arzneimittelforschung 52:109-12. 2002
    ..aureus and E. coli for as long as 30 h and 37 h, respectively, after the MIC values have been reached...
  29. doi request reprint Thymol-induced alterations in Candida albicans imaged by atomic force microscopy
    Pier Carlo Braga
    Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    Methods Mol Biol 736:401-10. 2011
    ..All of these phenomena lead to major surface alterations and deformities that also reduce the ability of fungi to adhere to mucosal cells, and decrease their virulence and infectiousness...
  30. ncbi request reprint Differences in the susceptibility of Streptococcus pyogenes to rokitamycin and erythromycin A revealed by morphostructural atomic force microscopy
    Pier Carlo Braga
    Centre of Respiratory Pharmacology, Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milano, Italy
    J Antimicrob Chemother 50:457-60. 2002
    ..pyogenes, whereas rokitamycin has a progressive action that leads to the formation of abnormally large cells, the loosening of chain structure and the formation of clusters...
  31. doi request reprint Vaginal gel adsorption and retention by human vaginal cells: visual analysis by means of inorganic and organic markers
    Pier Carlo Braga
    Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    Int J Pharm 373:10-5. 2009
    ....
  32. ncbi request reprint Imaging bacterial shape, surface, and appendages before and after treatments with antibiotics
    Pier Carlo Braga
    Department of Pharmacology and Center of Respiratory Pharmacology, School of Medicine, University of Milan, Italy
    Methods Mol Biol 242:179-88. 2004
  33. doi request reprint Imaging bacterial shape, surface, and appendages before and after treatment with antibiotics
    Pier Carlo Braga
    Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, Milan 20129, Italy
    Methods Mol Biol 736:391-9. 2011
    ..e., no vacuum is necessary), and effective three-dimensional magnification at submicron level...
  34. ncbi request reprint Imaging methods in atomic force microscopy
    Davide Ricci
    Department of Biophysical and Electronic Engineering, University of Genoa, Italy
    Methods Mol Biol 242:13-23. 2004
  35. ncbi request reprint How the atomic force microscope works
    Davide Ricci
    Department of Biophysical and Electronic Engineering, University of Genoa, Italy
    Methods Mol Biol 242:3-12. 2004
  36. ncbi request reprint Recognizing and avoiding artifacts in AFM imaging
    Davide Ricci
    Department of Biophysical and Electronic Engineering, University of Genoa, Italy
    Methods Mol Biol 242:25-37. 2004