Cristina Bottino

Summary

Affiliation: University of Genoa
Country: Italy

Publications

  1. ncbi request reprint What is a natural killer cell?
    Alessandro Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Nat Immunol 3:6-8. 2002
  2. ncbi request reprint Commentary: Regulated equilibrium between opposite signals: a general paradigm for T cell function?
    Alessandro Moretta
    Dipartimento di Medicina Sperimentale, Sezione di Istologia, Universita degli Studi di Genova, Via G B Marsano 10, I 16132 Genoa, Italy
    Eur J Immunol 34:2084-8. 2004
  3. ncbi request reprint Cellular ligands of activating NK receptors
    Cristina Bottino
    Istituto Giannina Gaslini, Largo G Gaslini 5, 16147 Genova, Italy
    Trends Immunol 26:221-6. 2005
  4. pmc Small round blue cell tumours: diagnostic and prognostic usefulness of the expression of B7-H3 surface molecule
    A Gregorio
    Department of Pathology, Gaslini Institute, Genoa, Italy
    Histopathology 53:73-80. 2008
  5. ncbi request reprint Combined genotypic and phenotypic killer cell Ig-like receptor analyses reveal KIR2DL3 alleles displaying unexpected monoclonal antibody reactivity: identification of the amino acid residues critical for staining
    Michela Falco
    Istituto Giannina Gaslini, Italy
    J Immunol 185:433-41. 2010
  6. ncbi request reprint Human natural killer cells: Molecular mechanisms controlling NK cell activation and tumor cell lysis
    Lorenzo Moretta
    Istituto Giannina Gaslini, Largo Gerolamo Gaslini 5, 16147 Genova Quarto, Italy
    Immunol Lett 100:7-13. 2005
  7. ncbi request reprint Different checkpoints in human NK-cell activation
    Lorenzo Moretta
    Istituto Giannina Gaslini, Largo Gerolamo Gaslini 5, 16147 Genova Quarto, Italy
    Trends Immunol 25:670-6. 2004
  8. ncbi request reprint Surface NK receptors and their ligands on tumor cells
    Lorenzo Moretta
    Istituto Giannina Gaslini, L go G Gaslini, Genova, Italy
    Semin Immunol 18:151-8. 2006
  9. ncbi request reprint Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genoa, Italy
    Cancer Res 64:9180-4. 2004
  10. ncbi request reprint Functional characterization of natural killer cells in type I leukocyte adhesion deficiency
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Istituto Giannina Gaslini, University of Genoa, Largo G Gaslini 5, 16147 Genoa, Italy
    Blood 109:4873-81. 2007

Collaborators

  • Domenico Mavilio
  • Guido Ferlazzo
  • Alessandro Moretta
  • Lorenzo Moretta
  • Maria Cristina Mingari
  • Maurizio Arico
  • Fabio Morandi
  • Daniela Pende
  • E Vivier
  • Sophie Caillat-Zucman
  • David Raulet
  • Stephanie Fabre
  • Jacques Zimmer
  • L Xerri
  • A S Fauci
  • Christian Chabannon
  • S Kottilil
  • Roberta Castriconi
  • Michela Falco
  • Claudia Cantoni
  • Elisa Romeo
  • Silvia Parolini
  • Emanuela Marcenaro
  • Alessandra Dondero
  • Massimo Vitale
  • Raffaella Augugliaro
  • Mariella Della Chiesa
  • Roberto Biassoni
  • Raffaella Meazza
  • Francesca Bellora
  • Marina Nanni
  • Simona Sivori
  • A Gregorio
  • Paola Vacca
  • Barbara Carnemolla
  • Francesca Negri
  • Nicolas Reymond
  • Maria Valeria Corrias
  • Pascale Andre
  • Romana Conte
  • Concetta Micalizzi
  • Fabrizio Loiacono
  • Valentina Cetica
  • Claudia Tuberosa
  • Stefania Martini
  • Stefania Marcenaro
  • A Dondero
  • Mirna Balsamo
  • M Mosconi
  • M V Corrias
  • R Castriconi
  • C Gambini
  • Lucia Notarangelo
  • Paolo Nozza
  • Luigi Notarangelo
  • Carola Prato
  • Maurilia Fiorini
  • Alessandro Raso
  • Gabriella Pietra
  • Pier Luigi Venturini
  • Ezio Fulcheri
  • Federico Prefumo
  • Mauro Costa
  • Edoardo Lanino
  • Angela Rita Sementa
  • Nicolas Anfossi
  • Catherine Farnarier
  • Marion Espeli
  • Elisabeth Devilard
  • Francois Romagne
  • Géraldine Ferracci
  • Anne Marie Imbert
  • Frederic Vely
  • Marc Lopez
  • Holli Conway
  • Tiffany Juarez
  • Patrice Dubreuil
  • Daniele Marras
  • Sophie Hue
  • Pascale Paul
  • Romano Millo
  • Lionel Donato
  • Henri de la Salle
  • Daniel Hanau

Detail Information

Publications34

  1. ncbi request reprint What is a natural killer cell?
    Alessandro Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Nat Immunol 3:6-8. 2002
  2. ncbi request reprint Commentary: Regulated equilibrium between opposite signals: a general paradigm for T cell function?
    Alessandro Moretta
    Dipartimento di Medicina Sperimentale, Sezione di Istologia, Universita degli Studi di Genova, Via G B Marsano 10, I 16132 Genoa, Italy
    Eur J Immunol 34:2084-8. 2004
    ....
  3. ncbi request reprint Cellular ligands of activating NK receptors
    Cristina Bottino
    Istituto Giannina Gaslini, Largo G Gaslini 5, 16147 Genova, Italy
    Trends Immunol 26:221-6. 2005
    ..However, although NK cells use different means to identify and fight target cells, target cells have various strategies to hide themselves, and disarm or even confuse the immune system...
  4. pmc Small round blue cell tumours: diagnostic and prognostic usefulness of the expression of B7-H3 surface molecule
    A Gregorio
    Department of Pathology, Gaslini Institute, Genoa, Italy
    Histopathology 53:73-80. 2008
    ..To assess whether the expression of B7-H3 surface molecule could improve differential diagnosis of small cell round tumours...
  5. ncbi request reprint Combined genotypic and phenotypic killer cell Ig-like receptor analyses reveal KIR2DL3 alleles displaying unexpected monoclonal antibody reactivity: identification of the amino acid residues critical for staining
    Michela Falco
    Istituto Giannina Gaslini, Italy
    J Immunol 185:433-41. 2010
    ..Our present data represent a substantial progress in the characterization of the NK cell repertoire and an improved phenotypic/functional definition of given KIR(+) subsets...
  6. ncbi request reprint Human natural killer cells: Molecular mechanisms controlling NK cell activation and tumor cell lysis
    Lorenzo Moretta
    Istituto Giannina Gaslini, Largo Gerolamo Gaslini 5, 16147 Genova Quarto, Italy
    Immunol Lett 100:7-13. 2005
    ..This clearly implies that activation of NK cells and of their potent effector mechanism are under the control of different checkpoints...
  7. ncbi request reprint Different checkpoints in human NK-cell activation
    Lorenzo Moretta
    Istituto Giannina Gaslini, Largo Gerolamo Gaslini 5, 16147 Genova Quarto, Italy
    Trends Immunol 25:670-6. 2004
    ..Thus, it appears that the activation of NK cells and their potentially harmful effector functions are under the control of different checkpoints...
  8. ncbi request reprint Surface NK receptors and their ligands on tumor cells
    Lorenzo Moretta
    Istituto Giannina Gaslini, L go G Gaslini, Genova, Italy
    Semin Immunol 18:151-8. 2006
    ..Here we briefly illustrate the main NK receptors and their cellular ligands and we delineate the major receptor/ligands interactions leading to NK cell activation and tumor cell lysis...
  9. ncbi request reprint Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genoa, Italy
    Cancer Res 64:9180-4. 2004
    ..Thus, assessment of the PVR surface levels may represent a novel useful criterion to predict the susceptibility/resistance of neuroblastomas to NK-mediated killing...
  10. ncbi request reprint Functional characterization of natural killer cells in type I leukocyte adhesion deficiency
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Istituto Giannina Gaslini, University of Genoa, Largo G Gaslini 5, 16147 Genoa, Italy
    Blood 109:4873-81. 2007
    ....
  11. ncbi request reprint Effector and regulatory events during natural killer-dendritic cell interactions
    Lorenzo Moretta
    Direzione Scientifica, Istituto Giannina Gaslini, Largo G Gaslini, Genova Quarto, Italy
    Immunol Rev 214:219-28. 2006
    ..These interactions also determine the quality and strength of the subsequent adaptive responses. Remarkably, NK cells appear to play a key role in this complex network...
  12. ncbi request reprint Selective cross-talk among natural cytotoxicity receptors in human natural killer cells
    Raffaella Augugliaro
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Eur J Immunol 33:1235-41. 2003
    ..These results suggest that a functional cross-talk specifically occurs among different NCR, possibly resulting in the amplification of the activating signals...
  13. ncbi request reprint Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells
    Cristina Bottino
    Istituto Giannina Gaslini, L go G Gaslini 5, Genova 16148, Italy
    Mol Immunol 41:569-75. 2004
    ..Finally, the ability of NK cells to interact with normal, non-transformed other cells such as dendritic cells (DC) appears to crucially contribute to the regulation of both innate and adaptive immune responses...
  14. ncbi request reprint Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells
    Michela Falco
    Istituto Giannina Gaslini, Genoa, Italy
    Eur J Immunol 34:1663-72. 2004
    ..Altogether our data indicate that NTBA is characterized by self recognition...
  15. pmc Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule
    Cristina Bottino
    Dipartimento di Medicina Sperimentale, Sezione di Istologia, Via G B Marsano 10, 16132 Genova, Italy
    J Exp Med 198:557-67. 2003
    ..This lysis was inhibited or even virtually abrogated upon mAb-mediated masking of DNAM-1 (on NK cells) or PVR or Nectin-2 ligands (on cell transfectants)...
  16. doi request reprint Soluble HLA-G dampens CD94/NKG2A expression and function and differentially modulates chemotaxis and cytokine and chemokine secretion in CD56bright and CD56dim NK cells
    Fabio Morandi
    Laboratory of Oncology, G Gaslini Scientific Institute, Genoa, Italy
    Blood 118:5840-50. 2011
    ..Signal transduction experiments showed sHLA-G-mediated down-modulation of Stat5 phosphorylation in PB NK cells. In conclusion, our data delineated novel mechanisms of sHLA-G-mediated inhibition of NK-cell functions...
  17. ncbi request reprint XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells
    Raffaella Meazza
    Istituto di Ricovero e Cura a Carattere Scientifico Azienda Ospedaliera Universitaria San Martino Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Eur J Immunol 44:1526-34. 2014
    ..The study sheds new light on the XLP1 immunological defect and on the cross-talk of inhibitory 2B4 with triggering NK (and T) receptors. ..
  18. pmc Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Via L B Alberti 2, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 101:12640-5. 2004
    ..These data suggest that 4Ig-B7-H3 molecules expressed at the tumor cell surface can exert a protective role from natural killer-mediated lysis by interacting with a still undefined inhibitory receptor expressed on natural killer cells...
  19. ncbi request reprint Analysis of natural killer cells in TAP2-deficient patients: expression of functional triggering receptors and evidence for the existence of inhibitory receptor(s) that prevent lysis of normal autologous cells
    Massimo Vitale
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Blood 99:1723-9. 2002
    ..Another possibility would be that TAP2(-/-) NK cells are missing a still unidentified triggering receptor involved in NK cell-mediated killing of PHA blasts...
  20. pmc Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation
    Simona Sivori
    Dipartimento di Medicina Sperimentale, Universita di Genova, Via L B Alberti 2, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 99:4526-31. 2002
    ....
  21. doi request reprint Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function
    Mariella Della Chiesa
    Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
    Eur J Immunol 38:2284-9. 2008
    ..Finally, soluble KIR2DS5-Fc fusion protein does not bind to cell transfectants expressing different HLA-C alleles, suggesting that, if KIR2DS5 does recognize HLA-C molecules, this may only occur in the presence of certain peptides...
  22. ncbi request reprint Human natural killer cells: their origin, receptors and function
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Eur J Immunol 32:1205-11. 2002
    ..As a consequence, NK cells lyse target cells that have lost (or express insufficient amounts of) MHC class I molecules, as frequently occurs in tumors and in cells infected by certain viruses...
  23. doi request reprint Human natural killer receptors and their ligands
    Roberto Biassoni
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Curr Protoc Immunol . 2002
    Human Natural Killer Receptors and Their Ligands (Roberto Biassoni and Cristina Bottino, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy; Claudia Cantoni, Universita degli Studi di Genova, Istituto Giannina Gaslini, Genova, ..
  24. ncbi request reprint Both CD133+ and CD133- medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK-mediated cytotoxicity
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Eur J Immunol 37:3190-6. 2007
    ..In particular, B7 homolog 3 (B7-H3) was expressed by all the medulloblastoma cell lines analyzed, while the presence of GD(2) and NB84 was restricted to given cell lines and/or marked a defined tumor cell subset...
  25. ncbi request reprint Human NK cells and their receptors
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Microbes Infect 4:1539-44. 2002
    ..host disease. This may lead to a true revolution in bone marrow transplantation, based on the exploitation of appropriate HLA-Cl I mismatches that can put NK cells in action...
  26. pmc Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Via L B Alberti 1, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 100:4120-5. 2003
    ..Our present data suggest a possible mechanism by which TGFbeta1-producing dendritic cells may acquire resistance to the NK-mediated attack...
  27. ncbi request reprint Analysis of natural killer cells isolated from human decidua: Evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK-cell function
    Paola Vacca
    Dipartamento di Oncologia, Biologia e Genetica, University of Genoa, Italy
    Blood 108:4078-85. 2006
    ..This might suggest that dNK cells, although potentially capable of killing, are inhibited in their function when interacting with cells expressing CD48...
  28. ncbi request reprint Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 107:2030-6. 2006
    ....
  29. ncbi request reprint CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity
    Emanuela Marcenaro
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Eur J Immunol 33:3367-76. 2003
    ..Thus, CD59-mediated costimulation of NK cells requires direct physical interaction of this GPI-linked protein with primary triggering NK receptors...
  30. ncbi request reprint PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Mol Immunol 42:463-9. 2005
    ..Importantly, the specific interaction between DNAM-1 (in NK cells) and PVR or Nectin-2 (in target cells) enhanced the NK-mediated lysis of tumor cells that was downregulated by mAb-mediated masking of the receptor or its ligands...
  31. ncbi request reprint Comparative analysis of human NK cell activation induced by NKG2D and natural cytotoxicity receptors
    Pascale Andre
    Innate Pharma SA, Marseille, France
    Eur J Immunol 34:961-71. 2004
    ..These data thus show that target recognition via NKG2D or NCR triggers all aspects of NK activation, and pave the way for further dissection of the signaling pathways induced by NK cell recognition of ULBP-1 and MICA...
  32. pmc DNAM-1 and PVR regulate monocyte migration through endothelial junctions
    Nicolas Reymond
    Institut National de la Santé et de la Recherche Médicale UMR599, Institut de Cancérologie de Marseille, IFR 137, 27 Bd Lei Roure, 13009 Marseille, France
    J Exp Med 199:1331-41. 2004
    ..Altogether, our results demonstrate that DNAM-1 regulates monocyte extravasation via its interaction with PVR expressed at endothelial junctions on normal cells...
  33. ncbi request reprint Cellular and molecular basis of natural killer and natural killer-like activity
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Via L B Alberti no 2, 16132 Genova, Italy
    Immunol Lett 88:89-93. 2003
    ....
  34. pmc Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates
    Domenico Mavilio
    Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15011-6. 2003
    ..This phenomenon is not attributed to a direct HIV-1 infection of NK cells; thus, this study may provide insight into the mechanisms of impaired host defenses in HIV-1 viremic patients...