Simona Boncompagni

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. pmc Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis
    Simona Boncompagni
    DNI Department of Neuroscience and Imaging, CeSI Center for Research on Ageing, University of G d Annunzio, Chieti, Italy
    PLoS ONE 7:e39962. 2012
  2. pmc The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging
    Simona Boncompagni
    IIM Interuniversitary Institute of Myology, DNI Department of Neuroscience and Imaging, Ce S I Centro Scienze dell Invecchiamento, University of Studi G d Annunzio, 66013 Chieti, Italy
    Aging Cell 9:958-70. 2010
  3. pmc Sequential stages in the age-dependent gradual formation and accumulation of tubular aggregates in fast twitch muscle fibers: SERCA and calsequestrin involvement
    Simona Boncompagni
    IIM Interuniversitary Institute of Myology, DNI Department of Neuroscience and Imaging, CeSI Centro Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, 66013, Chieti, Italy
    Age (Dordr) 34:27-41. 2012
  4. doi request reprint A subpopulation of rat muscle fibers maintains an assessable excitation-contraction coupling mechanism after long-standing denervation despite lost contractility
    Roberta Squecco
    Interuniversitary Institute of Myology, Chieti, Italy
    J Neuropathol Exp Neurol 68:1256-68. 2009
  5. pmc Mitochondria are linked to calcium stores in striated muscle by developmentally regulated tethering structures
    Simona Boncompagni
    Interuniversitary Institute of Myology, Department of Basic and Applied Medical Sciences, CeSI, Universita degli Studi G D Annunzio, I 66013 Chieti, Italy
    Mol Biol Cell 20:1058-67. 2009
  6. pmc Growth associated protein 43 is expressed in skeletal muscle fibers and is localized in proximity of mitochondria and calcium release units
    Simone Guarnieri
    Department of Neuroscience and Imaging DNI, University G D Annunzio, Chieti, Italy
    PLoS ONE 8:e53267. 2013
  7. ncbi request reprint Progressive disorganization of the excitation-contraction coupling apparatus in aging human skeletal muscle as revealed by electron microscopy: a possible role in the decline of muscle performance
    Simona Boncompagni
    CeSI, Centro Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, Chieti, CH I 66013, Italy
    J Gerontol A Biol Sci Med Sci 61:995-1008. 2006
  8. pmc Structural differentiation of skeletal muscle fibers in the absence of innervation in humans
    Simona Boncompagni
    Interuniversitary Institute of Miology, Centro Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, I 66013 Chieti, Italy
    Proc Natl Acad Sci U S A 104:19339-44. 2007

Collaborators

Detail Information

Publications8

  1. pmc Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis
    Simona Boncompagni
    DNI Department of Neuroscience and Imaging, CeSI Center for Research on Ageing, University of G d Annunzio, Chieti, Italy
    PLoS ONE 7:e39962. 2012
    ..These data suggest that in skeletal muscle the disruption of Tdn/CASQ link has a more profound effect on jSR architecture and myoplasmic Ca(2+) regulation than Jct/CASQ association...
  2. pmc The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging
    Simona Boncompagni
    IIM Interuniversitary Institute of Myology, DNI Department of Neuroscience and Imaging, Ce S I Centro Scienze dell Invecchiamento, University of Studi G d Annunzio, 66013 Chieti, Italy
    Aging Cell 9:958-70. 2010
    ....
  3. pmc Sequential stages in the age-dependent gradual formation and accumulation of tubular aggregates in fast twitch muscle fibers: SERCA and calsequestrin involvement
    Simona Boncompagni
    IIM Interuniversitary Institute of Myology, DNI Department of Neuroscience and Imaging, CeSI Centro Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, 66013, Chieti, Italy
    Age (Dordr) 34:27-41. 2012
    ..We conclude that TAs do not arise abruptly but are the final result of a gradually changing SR architecture and we suggest that the crystalline ATPase within the aggregates may be inactive...
  4. doi request reprint A subpopulation of rat muscle fibers maintains an assessable excitation-contraction coupling mechanism after long-standing denervation despite lost contractility
    Roberta Squecco
    Interuniversitary Institute of Myology, Chieti, Italy
    J Neuropathol Exp Neurol 68:1256-68. 2009
    ..Hence, these data provide a potential molecular explanation for the muscle recovery that occurs in response to rehabilitation strategies developed based on empirical clinical observations...
  5. pmc Mitochondria are linked to calcium stores in striated muscle by developmentally regulated tethering structures
    Simona Boncompagni
    Interuniversitary Institute of Myology, Department of Basic and Applied Medical Sciences, CeSI, Universita degli Studi G D Annunzio, I 66013 Chieti, Italy
    Mol Biol Cell 20:1058-67. 2009
    ....
  6. pmc Growth associated protein 43 is expressed in skeletal muscle fibers and is localized in proximity of mitochondria and calcium release units
    Simone Guarnieri
    Department of Neuroscience and Imaging DNI, University G D Annunzio, Chieti, Italy
    PLoS ONE 8:e53267. 2013
    ..This work leads the way to further investigation about the possible physiological and structural role of GAP43 protein in adult fiber function and disease...
  7. ncbi request reprint Progressive disorganization of the excitation-contraction coupling apparatus in aging human skeletal muscle as revealed by electron microscopy: a possible role in the decline of muscle performance
    Simona Boncompagni
    CeSI, Centro Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, Chieti, CH I 66013, Italy
    J Gerontol A Biol Sci Med Sci 61:995-1008. 2006
    ..These data indicate that in aging humans the EC coupling apparatus undergoes a partial disarrangement and a spatial reorganization that could interfere with an efficient delivery of Ca(2+) ions to the contractile proteins...
  8. pmc Structural differentiation of skeletal muscle fibers in the absence of innervation in humans
    Simona Boncompagni
    Interuniversitary Institute of Miology, Centro Scienze dell Invecchiamento, Universita degli Studi G D Annunzio, I 66013 Chieti, Italy
    Proc Natl Acad Sci U S A 104:19339-44. 2007
    ..Most importantly, the recovery occurs in the complete absence of motor and sensory innervation and of nerve-derived trophic factors, that is, solely under the influence of muscle activity induced by electrical stimulation...