Affiliation: University of Rome La Sapienza
- Prevalence and clinical picture of celiac disease in italian down syndrome patients: a multicenter studyM Bonamico
Department of Paediatrics, La Sapienza University, Rome, Italy
J Pediatr Gastroenterol Nutr 33:139-43. 2001..A multicenter research study of Down syndrome patients was carried out to estimate the prevalence of celiac disease in patients with Down syndrome and to show clinical characteristics and laboratory data of Down syndrome patients...
- Antiendomysial antibody detection in biopsy culture allows avoidance of gluten challenge in celiac childrenMargherita Bonamico
Department of Pediatrics and Department of Clinical Sciences, University of Rome La Sapienza, Viale Regina Elena 324, 00161, Rome, Italy
J Pediatr Gastroenterol Nutr 40:165-9; discussion 122-4. 2005..The aim of the present study was to use this in vitro system to determine whether it could be used to predict the clinical or histologic relapse to gluten challenge in CD children on a gluten-free diet (GFD)...
- Serologic and genetic markers of celiac disease: a sequential study in the screening of first degree relativesMargherita Bonamico
Department of Pediatrics, University of Rome La Sapienza, Viale Regina Elena 324, 00161 Rome, Italy
J Pediatr Gastroenterol Nutr 42:150-4. 2006..The prevalence of celiac disease (CD) among the relatives and the complications of an undiagnosed CD prompted us to identify a useful disease screening strategy...
- Tissue transglutaminase autoantibody detection in human saliva: a powerful method for celiac disease screeningMargherita Bonamico
Institute of Paediatrics and Department of Clinical Science, University of Rome La Sapienza, Italy
J Pediatr 144:632-6. 2004..To test the possibility of detecting tissue transglutaminase autoantibodies (tTG-Abs) in saliva with a novel sensitive fluid-phase radioimmunoassay (RIA)...
- Patchy villous atrophy of the duodenum in childhood celiac diseaseMargherita Bonamico
Department of Pediatrics, University of Rome La Sapienza, Rome, Italy
J Pediatr Gastroenterol Nutr 38:204-7. 2004..The authors evaluated the presence and the distribution of villous atrophy in children with celiac disease to see whether this histologic pattern exists in children...
- Duodenal bulb biopsies in celiac disease: a multicenter studyMargherita Bonamico
Department of Paediatrics, University La Sapienza of Rome, Rome, Italy
J Pediatr Gastroenterol Nutr 47:618-22. 2008....
- Radioimmunological detection of anti-transglutaminase autoantibodies in human saliva: a useful test to monitor coeliac disease follow-upM Bonamico
Department of Paediatrics, Sapienza University of Rome, Rome, Italy
Aliment Pharmacol Ther 28:364-70. 2008..Serum radioimmunoassay (RIA) tissue transglutaminase autoantibodies (tTG-Abs) proved to be a sensitive test also during coeliac disease (CD) follow-up. We demonstrated that RIA tTG-Abs could be detected in human saliva...
- First salivary screening of celiac disease by detection of anti-transglutaminase autoantibody radioimmunoassay in 5000 Italian primary schoolchildrenMargherita Bonamico
Departments of Paediatrics, La Sapienza University of Rome, Italy
J Pediatr Gastroenterol Nutr 52:17-20. 2011..The aim was to identify CD in 6- to 8-year-old children for a timely diagnosis, start gluten-free diet (GFD) in compliant subjects, achieve the growth target, and prevent CD complications...
- Celiac disease and lamellar ichthyosis. Case study analysis and review of the literatureRaffaella Nenna
Department of Pediatrics, I Faculty, Sapienza University of Rome, Italy
Acta Dermatovenerol Croat 19:268-70. 2011..After 1-year follow-up, the girl showed complete normalization of bone mineral density. The introduction of the gluten-free diet did not lead to lesion repair, but the child reported significant improvement of her quality of life...
- Evidence of a selective epitope loss of anti-transglutaminase immunoreactivity in gluten-free diet celiac sera: a new tool to distinguish disease-specific immunoreactivitiesC Tiberti
Dept of Clinical Sciences, University of Rome La Sapienza, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy
Clin Immunol 121:40-6. 2006....
- Radioimmunoassay to detect antitransglutaminase autoantibodies is the most sensitive and specific screening method for celiac diseaseM Bonamico
Istituto di Clinica Pediatrica, Dipartimento di Scienze Cliniche, Medicina Sperimentale e Patologia, , Rome, Italy
Am J Gastroenterol 96:1536-40. 2001..If our data are confirmed by studies on larger series, tissue transglutaminase RIA could be proposed as the best screening method for celiac patients...
- Oligotyping of Italian celiac patients with the 11th International Histocompatibility Workshop reagentsP Ferrante
Department of Experimental Medicine, University La Sapienza, Rome, Italy
Tissue Antigens 39:38-9. 1992..86). 7 patients (12.7%) were negative for the DQA1*0501/B1*0201 dimer: 3 of them were DR4 (5.4%) and the others typed as DR1,5; 1,7; 5,7 and w6,7. No patient was negative for both DQA1*0501 and DQB1*0201 alleles...
- Different dose effect of HLA-DQ alpha beta heterodimers in insulin-dependent diabetes mellitus and celiac disease susceptibilityF Petronzelli
Department of Experimental Medicine, La Sapienza University, Rome, Italy
Hum Immunol 36:156-62. 1993....
- Celiac disease-associated transglutaminase autoantibody target domains at diagnosis are age and sex dependentC Tiberti
Department of Clinical Sciences, University La Sapienza, Rome, Italy
Clin Immunol 109:318-24. 2003..Our data identify a subset of CD patients showing a strong humoral tTG immunoreactivity at diagnosis, thus suggesting that age and sex influence the anti-tTG autoantibody response...
- HLA antigens and antigliadin antibodies in coeliac diseaseM Bonamico
I Clinica Pediatrica, , Rome, Italy
Dis Markers 9:313-7. 1991..The observation that coeliac children negative for DR3 and DR7 showed lower AGA levels is consistent with clinical and genetic heterogeneity of coeliac disease...
- Usefulness of endoscopic small intestinal biopsies in children with coeliac diseaseF M Magliocca
Department of Experimental Medicine, Faculty of Medicine, University of Rome La Sapienza, Italy
Ital J Anat Embryol 106:329-35. 2001..In our opinion, small intestinal biopsies obtained via endoscopy are more reliable than the peroral capsule biopsies in order to identify patchy mucosal atrophy and could be very useful for a correct diagnosis in CD patients...
- Size and dynamics of mucosal and peripheral IL-17A+ T-cell pools in pediatric age, and their disturbance in celiac diseaseR La Scaleia
Department of Experimental Medicine, Sapienza University, Rome, Italy
Mucosal Immunol 5:513-23. 2012....
- CTLA-4 +49 A/G dimorphism in Italian patients with celiac diseaseBarbara Mora
Department of Experimental Medicine and Pathology, Institute of Clinical Pediatrics, University of Rome La Sapienza, Italy
Hum Immunol 64:297-301. 2003..These data support CTLA-4 as a predisposing gene for CD in an Italian population with a prominent role in patients not carrying the high-risk human leukocyte antigen-DQ2 molecules...
- HLA-DQB1*02 dose effect on RIA anti-tissue transglutaminase autoantibody levels and clinicopathological expressivity of celiac diseaseRaffaella Nenna
Departments of Paediatrics, Sapienza University, Rome, Italy
J Pediatr Gastroenterol Nutr 47:288-92. 2008..Our aim was to investigate whether the DQB1*02 allele could influence tTGAb titers and the clinicopathological expressivity of the disease...
- Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal childrenLucia Pacifico
Department of Pediatrics, La Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
Eur J Endocrinol 158:323-32. 2008..This finding raises the possibility that the infection might affect growth in children by reducing the ghrelin production...
- Body composition in coeliac disease adolescents on a gluten-free diet: a longitudinal studyM C Carbone
Institute of Paediatrics, University of La Sapienza Policlinico Umberto I, Viale Regina Elena 324, I 00161, Rome, Italy
Acta Diabetol 40:S171-3. 2003..005). In conclusion, our study demonstrates that adolescence is a period where some parameters of body composition can still be recovered...
- HLA-DQ and susceptibility to celiac disease: evidence for gender differences and parent-of-origin effectsFrancesca Megiorni
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
Am J Gastroenterol 103:997-1003. 2008....
- Association of the matrix metalloproteinase-3 (MMP-3) promoter polymorphism with celiac disease in male subjectsBarbara Mora
Department of Experimental Medicine and Pathology, University of Rome La Sapienza, Rome, Italy
Hum Immunol 66:716-20. 2005..Homozygosity for the 6A allele appears as a risk factor for CD only in men, which is different from the HLA susceptibility alleles that confer a higher risk in women...
- Search for coeliac disease susceptibility loci on 7q11.23 candidate region: absence of association with the ELN17 microsatellite markerR Grillo
Department of Experimental Medicine, University of Rome La Sapienza, Rome, Italy
Hum Hered 50:180-3. 2000..The analysis of 74 Italian CD families provided no evidence of association with the ELN17 marker...
- HLA-DQ and risk gradient for celiac diseaseFrancesca Megiorni
Department of Experimental Medicine, Sapienza University of Rome, Italy
Hum Immunol 70:55-9. 2009..Those siblings and parents with no susceptible factors were not affected. These findings indicate the impact of the HLA test for CD in clinical practice...
- A rapid and sensitive method to detect specific human lymphocyte antigen (HLA) class II alleles associated with celiac diseaseFrancesca Megiorni
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy
Clin Chem Lab Med 46:193-6. 2008....
- Prevalence and clinical picture of celiac disease in Turner syndromeMargherita Bonamico
Department of Pediatrics, University of Rome La Sapienza, 00161 Roma, Italy
J Clin Endocrinol Metab 87:5495-8. 2002..4%) of CD in a large series of TS patients. Moreover, the subclinical picture in 60% of the cases, the diagnostic delay, and the incidence of other autoimmune disorders suggest that routine screening of CD in TS is indicated...
- Analysis of candidate genes on chromosomes 5q and 19p in celiac diseaseAnna Latiano
U O Gastroenterologia e Lab di Ricerca I R C C S Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
J Pediatr Gastroenterol Nutr 45:180-6. 2007..Additionally, any possible correlation with the HLA-DQ status was investigated. Finally, our data were pooled with the results of other studies by a meta-analysis...
- Which is the best screening test for celiac disease in Down syndrome children?Margherita Bonamico
J Pediatr Gastroenterol Nutr 40:125-7. 2005
- Evaluation of stool antigen test, PCR on ORAL samples and serology for the noninvasive detection of Helicobacter pylori infection in childrenMargherita Bonamico
Istituto di Clinica Pediatrica, Universita di Roma La Sapienza, Roma, Italy
Helicobacter 9:69-76. 2004..pylori stool antigen, the polimerase chain reaction for identification of bacterial DNA on the oral cavity and the serum specific antibodies...
- Autoimmune thyroid disease and celiac disease in childrenNicoletta Ansaldi
Azienda Ospedaliera O I R M S Anna, III Divisione Universitaria di Pediatria, Servizio di Gastroenterologia, Universita di Torino, Italy
J Pediatr Gastroenterol Nutr 37:63-6. 2003..The aim of this multicenter study was to establish the prevalence of autoimmune thyroid involvement in a large series of pediatric patients with CD...