L Bolondi

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis
    L Bolondi
    Dipartimento di Medicina Interna e Gastroenterologia, Universita di Bologna, Italia
    Gut 48:251-9. 2001
  2. ncbi Diurnal changes of fibrinolysis in patients with liver cirrhosis and esophageal varices
    F Piscaglia
    Department of Internal Medicine, University of Bologna, Bologna, Italy
    Hepatology 31:349-57. 2000
  3. ncbi Screening for hepatocellular carcinoma in cirrhosis
    Luigi Bolondi
    Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S. Orsola Malpighi, Via Albertoni 15, 40138 Bologna, Italy
    J Hepatol 39:1076-84. 2003
  4. ncbi Value of splanchnic Doppler ultrasound in the diagnosis of portal hypertension
    F Piscaglia
    Division of Internal Medicine, University of Bologna, Via Albertoni, Bologna, Italy
    Ultrasound Med Biol 27:893-9. 2001
  5. ncbi Pilot study of triple antiviral therapy for chronic hepatitis C in interferon alpha non-responders
    S Brillanti
    Department of Internal Medicine and Gastroenterology, Policlinico S Orsola, University of Bologna, Italy
    Ital J Gastroenterol Hepatol 31:130-4. 1999
  6. ncbi Influence of esophageal varices and spontaneous portal-systemic shunts on postprandial splanchnic hemodynamics
    S Siringo
    Dipartimento di Medicina Interna e Gastroenterologia, , Italy
    Am J Gastroenterol 96:550-6. 2001
  7. ncbi Mars and Prometheus: our clinical experience in acute chronic liver failure
    S Faenza
    Department of Surgery, Intensive Care and Transplantation, Policlinico Sant Orsola, Bologna, Italy
    Transplant Proc 40:1169-71. 2008
  8. ncbi Acute systemic, splanchnic and renal haemodynamic changes induced by molecular adsorbent recirculating system (MARS) treatment in patients with end-stage cirrhosis
    G Donati
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Aliment Pharmacol Ther 26:717-26. 2007
  9. ncbi Liver transplantation for hepatocellular carcinoma: results of down-staging in patients initially outside the Milan selection criteria
    M Ravaioli
    Department of Liver and Multi organ Transplantation, Pathology Division of The F Addarii Institute, Sant Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    Am J Transplant 8:2547-57. 2008
  10. ncbi Small (<or=3 cm) hepatocellular carcinoma in cirrhosis: the role of double contrast agents in MR imaging vs. multidetector-row CT
    R Golfieri
    Radiologia Malpighi, Azienda Ospedaliero Universitaria di Bologna, Policlinico S Orsola Malpighi, Universita di Bologna, Via Albertoni 15, 40138, Bologna, Italy
    Radiol Med 114:1239-66. 2009

Detail Information

Publications96

  1. ncbi Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis
    L Bolondi
    Dipartimento di Medicina Interna e Gastroenterologia, Universita di Bologna, Italia
    Gut 48:251-9. 2001
    ..This neoplasm is associated with liver cirrhosis (LC) in more than 90% of cases. Early diagnosis and treatment of HCC are expected to improve survival of patients...
  2. ncbi Diurnal changes of fibrinolysis in patients with liver cirrhosis and esophageal varices
    F Piscaglia
    Department of Internal Medicine, University of Bologna, Bologna, Italy
    Hepatology 31:349-57. 2000
    ....
  3. ncbi Screening for hepatocellular carcinoma in cirrhosis
    Luigi Bolondi
    Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S. Orsola Malpighi, Via Albertoni 15, 40138 Bologna, Italy
    J Hepatol 39:1076-84. 2003
  4. ncbi Value of splanchnic Doppler ultrasound in the diagnosis of portal hypertension
    F Piscaglia
    Division of Internal Medicine, University of Bologna, Via Albertoni, Bologna, Italy
    Ultrasound Med Biol 27:893-9. 2001
    ..60 and 12 cm/s(-1), which appeared to be, therefore, the most favorable parameters for the clinical practice. Their use may limit the need for endoscopy to search for varices...
  5. ncbi Pilot study of triple antiviral therapy for chronic hepatitis C in interferon alpha non-responders
    S Brillanti
    Department of Internal Medicine and Gastroenterology, Policlinico S Orsola, University of Bologna, Italy
    Ital J Gastroenterol Hepatol 31:130-4. 1999
    ..No effective therapy exists for interferon non-responding chronic hepatitis C patients...
  6. ncbi Influence of esophageal varices and spontaneous portal-systemic shunts on postprandial splanchnic hemodynamics
    S Siringo
    Dipartimento di Medicina Interna e Gastroenterologia, , Italy
    Am J Gastroenterol 96:550-6. 2001
    ..CONCLUSIONS: Our results show that the hemodynamic response to meal in patients with liver cirrhosis is influenced by the presence and size of esophageal varices and the presence of spontaneous portal-systemic shunts...
  7. ncbi Mars and Prometheus: our clinical experience in acute chronic liver failure
    S Faenza
    Department of Surgery, Intensive Care and Transplantation, Policlinico Sant Orsola, Bologna, Italy
    Transplant Proc 40:1169-71. 2008
    ..In our clinical context, there are two groups that practice blood purification treatments on acute or chronic liver failure (AoCLF) patients: one group used MARS (molecular adsorbent recirculating system) and the other Prometheus...
  8. ncbi Acute systemic, splanchnic and renal haemodynamic changes induced by molecular adsorbent recirculating system (MARS) treatment in patients with end-stage cirrhosis
    G Donati
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Aliment Pharmacol Ther 26:717-26. 2007
    ..To evaluate the acute effect of treatment with the molecular adsorbent recirculating system (MARS) on splanchnic, renal and systemic haemodynamics in patients with end-stage cirrhosis...
  9. ncbi Liver transplantation for hepatocellular carcinoma: results of down-staging in patients initially outside the Milan selection criteria
    M Ravaioli
    Department of Liver and Multi organ Transplantation, Pathology Division of The F Addarii Institute, Sant Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    Am J Transplant 8:2547-57. 2008
    ..The actuarial intention-to-treat survival was 27/48 patients (56.3%) in the down-staging and 81/129 cases (62.8%) in the Milan group, p = n.s. The proposed down-staging criteria provide a comparable outcome to the conventional criteria...
  10. ncbi Small (<or=3 cm) hepatocellular carcinoma in cirrhosis: the role of double contrast agents in MR imaging vs. multidetector-row CT
    R Golfieri
    Radiologia Malpighi, Azienda Ospedaliero Universitaria di Bologna, Policlinico S Orsola Malpighi, Universita di Bologna, Via Albertoni 15, 40138, Bologna, Italy
    Radiol Med 114:1239-66. 2009
    ..dynamic MRI plus SPIO-MRI (double-contrast MRI: DC-MRI) for the detection of small (<or=3 cm) hepatocellular carcinomas (HCCs)...
  11. ncbi Influence of liver fibrosis on hepatic artery Doppler resistance index in chronic hepatitis of viral origin
    F Piscaglia
    Division of Internal Medicine, Dept. of Internal Medicine and Gastroenterology, University of Bologna, Azienda Ospedaliera S. Orsola-Malpighi, Bologna, Italy
    Scand J Gastroenterol 36:647-52. 2001
    ..CONCLUSIONS: The increase in hepatic artery resistance index appears to be influenced by the extent of fibrous tissue deposition in the liver, determined by chronic inflammation and repair and, secondly, by ageing...
  12. ncbi Left ventricular volumes in liver cirrhosis
    F Piscaglia
    Division of Internal Medicine, University of Bologna, Italy
    Dig Liver Dis 32:392-7. 2000
    ..Patients with alcoholic cirrhosis have left ventricular dimensions similar to controls. Few data have been reported in patients with cirrhosis of viral origin...
  13. ncbi Assessment of liver fibrosis in transplant recipients with recurrent HCV infection: usefulness of transient elastography
    F Corradi
    Department of Internal Medicine and Gastroenterology, Division of Internal Medicine Bolondi, Italy
    Dig Liver Dis 41:217-25. 2009
    ..Progression of recurrent hepatitis C is accelerated in liver transplant recipients, leading to special need of non-invasive validated methods to estimate liver fibrosis...
  14. ncbi Role of real-time contrast-enhanced ultrasound in the assessment of metastatic portal vein thrombosis
    A Venturi
    Department of Internal Medicine and Gastroenterology, St Orsola Malpighi University Hospital, Bologna, Italy
    Ultraschall Med 28:75-8. 2007
    ....
  15. ncbi Tumor doubling time predicts recurrence after surgery and describes the histological pattern of hepatocellular carcinoma on cirrhosis
    Alessandro Cucchetti
    Dipartimento di Discipline Chirurgiche, Rianimatorie e dei Trapianti, University of Bologna, Policlinico S.Orsola, Via Massarenti 9, 40138 Bologna, Italy
    J Hepatol 43:310-6. 2005
    ..007), undifferentiation (P=0.003) and high alpha-fetoprotein levels (P=0.011). CONCLUSIONS: DT is easy to estimate and indicates the prognosis of single HCCs prior to liver resection...
  16. ncbi Diffusion MRI shows increased water apparent diffusion coefficient in the brains of cirrhotics
    R Lodi
    Department of Clinical Medicine, Internal Medicine and Gastroenterology, University of Bologna, Italy
    Neurology 62:762-6. 2004
    ..Brain edema and increased intracranial pressure worsen prognosis in patients with end-stage chronic cirrhosis...
  17. ncbi Analysis of risk factors for early hepatic artery thrombosis after liver transplantation. Possible contribution of reperfusion in the early morning
    F Piscaglia
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, S Orsola Malpighi Hospital, Via Albertoni 15, 40138 Bologna, Italy
    Dig Liver Dis 39:52-9. 2007
    ....
  18. ncbi Liver transplantation with the Meld system: a prospective study from a single European center
    M Ravaioli
    Liver and Multi-organ Transplantation, Sant 'Orsola-Malpighi Hospital, University of Bologna, Italy
    Am J Transplant 6:1572-7. 2006
    ..4% vs. 14.9%, p = n.s.) as was the 1-year patient survival on the list (83% vs. 84%, p = n.s.). The Meld allocation system improved the outcome of patients with or without HCC on the list...
  19. ncbi Review article: liver transplantation for HCC. Treatment options on the waiting list
    L Bolondi
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology and Division of General and Transplantation Surgery, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
    Aliment Pharmacol Ther 17:145-50. 2003
    ..However, the overall efficacy of this approach will be established only in some years...
  20. ncbi Different haemodynamic effects of a single dose of long-acting isosorbide-5-mononitrate in healthy subjects and patients with cirrhotic portal hypertension
    F Piscaglia
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Azienda S Orsola Malpighi, Via Albertoni 15, 40138 Bologna, Italy
    Dig Liver Dis 36:594-602. 2004
    ..The action pathways of nitrates are hypothesised to be deranged in cirrhosis...
  21. ncbi Triple antiviral therapy as a new option for patients with interferon nonresponsive chronic hepatitis C
    S Brillanti
    Department of Internal Medicine and Gastroenterology, Policlinico S Orsola Malpighi, University of Bologna, Italy
    Hepatology 32:630-4. 2000
    ..The safety profile was similar in the 2 groups. In conclusion, in patients with interferon-nonresponsive chronic hepatitis C, triple antiviral therapy for 1 year results in a high rate of sustained biochemical and virologic responses...
  22. ncbi Management of small hepatocellular carcinoma
    S Leoni
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Acta Gastroenterol Belg 69:230-5. 2006
    ..This review describes some critical points regarding the detection, diagnosis and therapeutic management of small nodules of HCC in cirrhotic patients...
  23. ncbi Artificial neural network is superior to MELD in predicting mortality of patients with end-stage liver disease
    A Cucchetti
    Dipartimento di Discipline Chirurgiche, Rianimatorie e dei Trapianti, University of Bologna, S Orsola Malpighi Hospital, 9 40138 Bologna, Italy
    Gut 56:253-8. 2007
    ....
  24. ncbi Review article: percutaneous treatment of hepatocellular carcinoma
    S Gaiani
    Dipartimento di Medicina Interna e Gastroenterologia, Universita di Bologna, Italy
    Aliment Pharmacol Ther 17:103-10. 2003
    ..Randomized controlled trials are needed in order to assess treatment response, long-term survival, rate of complication and cost-efficacy of newer technologies in comparison to ethanol injection...
  25. ncbi The impact of vascular and nonvascular findings on the noninvasive diagnosis of small hepatocellular carcinoma based on the EASL and AASLD criteria
    Simona Leoni
    Department of Digestive Diseases and Internal Medicine, University of Bologna, Bologna, Italy
    Am J Gastroenterol 105:599-609. 2010
    ....
  26. ncbi Comparison of recurrence of hepatocellular carcinoma after resection in patients with cirrhosis to its occurrence in a surveilled cirrhotic population
    Alessandro Cucchetti
    Department of Surgery and Transplantation, University of Bologna, Italy
    Ann Surg Oncol 16:413-22. 2009
    ..Annual incidence of HCC 2 years or more after resection may be similar to that of general patients because the same risk factors are involved; assessment of these characteristics could be useful in tailoring clinical management...
  27. ncbi Molecular adsorbent recirculating system (MARS) application in liver failure: clinical and hemodepurative results in 22 patients
    S Stefoni
    Nephrology, Dialysis and Renal Transplantation Unit, S Orsola University Hospital, Bologna, Italy
    Int J Artif Organs 29:207-18. 2006
    ..Acute liver failure (ALF) and acute on chronic liver failure (ACLF) still show a poor prognosis. MARS was used in 22 patients with ALF or ACLF to prolong patient survival for liver function recovery or as a bridge to transplantation...
  28. ncbi Influence of the spleen on portal haemodynamics: a non-invasive study with Doppler ultrasound in chronic liver disease and haematological disorders
    F Piscaglia
    Dept of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Scand J Gastroenterol 37:1220-7. 2002
    ..In an attempt to elucidate these questions, we assessed splanchnic haemodynamics in chronic liver diseases and various other disorders with splenomegaly...
  29. ncbi Enhanced uptake of lactosaminated human albumin by rat hepatocarcinomas: implications for an improved chemotherapy of primary liver tumors
    Giuseppina Di Stefano
    Department of Experimental Pathology, University of Bologna, Italy
    Liver Int 25:854-60. 2005
    ..CONCLUSIONS: The present results suggest that in the chemotherapy of HCCs expressing the ASGP-R the extra-hepatic toxicity of anticancer agents can be reduced by conjugation to L-HSA...
  30. ncbi A conjugate of doxorubicin with lactosaminated albumin enhances the drug concentrations in all the forms of rat hepatocellular carcinomas independently of their differentiation grade
    Giuseppina Di Stefano
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Liver Int 26:726-33. 2006
    ....
  31. ncbi Orthotopic liver transplantation (OLT): Contribution of diagnostic imaging and interventional radiology in preparing the transplantation and managing complications. Part 1: Indications, surgical technique, diagnostic imaging and interventional radiology b
    Rita Golfieri
    , Pad. Albertoni, Dipartimento Area Radiologica Azienda Ospedaliera di Bologna, Policlinico S. Orsola-Malpighi, , Bologna, Italy
    Radiol Med 110:391-430; quiz 431-2. 2005
  32. ncbi Doxorubicin coupled to lactosaminated albumin: effect of heterogeneity in drug load on conjugate disposition and hepatocellular carcinoma uptake in rats
    Giuseppina Di Stefano
    Department of Experimental Pathology, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Eur J Pharm Sci 33:191-8. 2008
    ..This suggests that after administration of the dose of DOXO used in the present experiments the conjugate molecules with lower or higher drug load can exert comparable pharmacological and toxic effects...
  33. ncbi Impact of gadoxetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance on the non-invasive diagnosis of small hepatocellular carcinoma: a prospective study
    A Granito
    Department of Medical and Surgical Sciences, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
    Aliment Pharmacol Ther 37:355-63. 2013
    ..Gadoxetic acid (Gd-EOB-DTPA) is a 'hepatocyte-specific' contrast agent for magnetic resonance (MR) in both the vascular and the hepatobiliary phases...
  34. ncbi New perspectives for the use of contrast-enhanced liver ultrasound in clinical practice
    L Bolondi
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Via Albertoni 15, 40138 Bologna, Italy
    Dig Liver Dis 39:187-95. 2007
    ..Therefore, it is necessary to take measures in order to meet the demand for an increasing number of these procedures...
  35. ncbi MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma
    F Fornari
    1Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Policlinico S Orsola, Bologna, Italy
    Oncogene 27:5651-61. 2008
    ..These findings establish a basis toward the development of therapeutic strategies aimed at blocking miR-221 in HCC...
  36. ncbi Clinical trial: peg-interferon alfa-2b and ribavirin for the treatment of genotype-1 hepatitis C recurrence after liver transplantation
    F Lodato
    Department of Digestive Diseases and Internal Medicine, Azienda Ospedaliero Universitaria Policlinico Sant Orsola Malpighi, Bologna, Italy
    Aliment Pharmacol Ther 28:450-7. 2008
    ..Treatment of hepatitis C virus (HCV) recurrence after liver transplantation (LT) is difficult with low response rates...
  37. ncbi Serum xanthine oxidase in human liver disease
    M G Battelli
    Department of Experimental Pathology, S. Orsola Hospital, University of Bologna, Italy
    Am J Gastroenterol 96:1194-9. 2001
    ..No correlation between XO levels and histological or serum evidence of hepatocyte necrosis was found in these patients...
  38. ncbi Increased prevalence of fatty liver in arterial hypertensive patients with normal liver enzymes: role of insulin resistance
    G Donati
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Azienda S Orsola-Malpighi, Bologna, Italy
    Gut 53:1020-3. 2004
    ..029), and body mass index (p = 0.048). CONCLUSION: The higher prevalence of non-alcoholic fatty liver in non-obese hypertensive patients with normal liver enzymes appears to be related to increases in insulin resistance and body weight...
  39. ncbi Measurement of oxidative stress in human liver by EPR spin-probe technique
    L Valgimigli
    Department of Organic Chemistry, A Mangini, University of Bologna, Italy
    Free Radic Res 33:167-78. 2000
    ..8 x 10(-9) mol/mg; p < 0.005). NVLD also showed significantly higher ROS levels compared to hepatitis B (p < 0.04) and hepatitis C (p < 0.04). The mechanism, potentiality and limitations of our method are discussed...
  40. ncbi Effect of potassium canrenoate, an anti-aldosterone agent, on incidence of ascites and variceal progression in cirrhosis
    Luigi Bolondi
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Clin Gastroenterol Hepatol 4:1395-402. 2006
    ....
  41. ncbi Doxorubicin coupled to lactosaminated human albumin: a hepatocellular carcinoma targeted drug
    Luigi Fiume
    Department of Experimental Pathology, University of Bologna, Italy
    Drug Discov Today 13:1002-9. 2008
    ..Unexpectedly, it was found that the conjugate enhanced DOXO concentrations in all forms of HCCs, independently of their differentiation grade...
  42. ncbi A new priority policy for patients with hepatocellular carcinoma awaiting liver transplantation within the model for end-stage liver disease system
    Fabio Piscaglia
    Department of Internal Medicine and Gastroenterology, Sant Orsola Malpighi Hospital, Bologna, Italy
    Liver Transpl 13:857-66. 2007
    ..This model allows the timely transplantation of patients with HCC without severely affecting the outcome of patients without HCC...
  43. ncbi Real time contrast enhanced ultrasonography in detection of liver metastases from gastrointestinal cancer
    Fabio Piscaglia
    Division Internal Medicine, Azienda Ospedaliero Universitaria S, Orsola Malpighi, Bologna, Italy
    BMC Cancer 7:171. 2007
    ....
  44. ncbi Metabolic Syndrome: prevalence and prediction of mortality in elderly individuals
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University of Bologna, Via Massarenti, 9 40138 Bologna, Italy
    Diabetes Care 29:2471-6. 2006
    ....
  45. ncbi Prediction of significant fibrosis in hepatitis C virus infected liver transplant recipients by artificial neural network analysis of clinical factors
    Fabio Piscaglia
    Department of Internal Medicine and Gastroenterology, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
    Eur J Gastroenterol Hepatol 18:1255-61. 2006
    ....
  46. ncbi Characterization of liver lesions by real-time contrast-enhanced ultrasonography
    Natascia Celli
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, Alma Mater Studiorum, University of Bologna, Italy
    Eur J Gastroenterol Hepatol 19:3-14. 2007
    ....
  47. ncbi The safety of Sonovue in abdominal applications: retrospective analysis of 23188 investigations
    Fabio Piscaglia
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Ultrasound Med Biol 32:1369-75. 2006
    ....
  48. ncbi Usefulness of contrast-enhanced perfusional sonography in the assessment of hepatocellular carcinoma hypervascular at spiral computed tomography
    Stefano Gaiani
    Dipartimento di Medicina Interna e Gastroenterologia, Alma Mater Studiorum, Universita di Bologna, Via Albertoni 15, 40138 Bologna, Italy
    J Hepatol 41:421-6. 2004
    ....
  49. ncbi Durable complete response of hepatocellular carcinoma after metronomic capecitabine
    Giovanni Brandi
    Department of Hematology and Oncological Sciences L e A Seràgnoli, Policlinico Sant Orsola Malpighi, University of Bologna, Bologna, Italy
    Tumori 96:1028-30. 2010
    ..Recently, various antiangiogenic targeted agents have shown promising activity at different levels of evidence in patients with advanced HCC, suggesting that such treatments might be effective...
  50. ncbi Effect of Levovist on splanchnic hemodynamics in cirrhotic patients
    Stefano Gaiani
    Dipartimento di Medicina Interna e Gastroenterologia, Universita degli Studi di Bologna, Bologna, Italy
    Ultrasound Med Biol 29:643-8. 2003
    ..It might have implications on harmonic imaging US protocols designed to image the cirrhotic liver in the early arterial phase...
  51. ncbi MiR-199a-3p regulates mTOR and c-Met to influence the doxorubicin sensitivity of human hepatocarcinoma cells
    Francesca Fornari
    Centro di Ricerca Biomedica Applicata e Dipartimento di Medicina Interna, Policlinico S Orsola Malpighi e Università di Bologna, Bologna, Italy
    Cancer Res 70:5184-93. 2010
    ..These results suggest that tactics to regulate mTOR and c-Met by elevating levels of miR-199a-3p may have therapeutic benefits in highly lethal cancers such as HCC...
  52. ncbi Liver metastases from rectal carcinoma: disease progression during chemotherapy despite loss of arterial-phase hypervascularity on real-time contrast-enhanced harmonic sonography at low acoustic energy
    Fabio Piscaglia
    Division of Internal Medicine, University of Bologna, Azienda Ospedaliera S. Orsola-Malpighi, Via Albertoni 15, 40138 Bologna, Italy
    J Clin Ultrasound 31:387-91. 2003
    ..In this case, changes in arterial perfusion over time did not parallel the response of liver metastases to chemotherapy...
  53. ncbi Criteria for diagnosing benign portal vein thrombosis in the assessment of patients with cirrhosis and hepatocellular carcinoma for liver transplantation
    Fabio Piscaglia
    Division of Internal Medicine, Department of Digestive Disease and Internal Medicine, St Orsola Malpighi University Hospital, Bologna, Italy
    Liver Transpl 16:658-67. 2010
    ..In conclusion, for a patient with HCC and portal vein thrombosis, appropriate investigations can establish whether the thrombosis is benign; patients with HCC and benign portal vein thrombosis are candidates for liver transplantation...
  54. ncbi Cost analysis of recall strategies for non-invasive diagnosis of small hepatocellular carcinoma
    Fabio Piscaglia
    Division of Internal Medicine, Department of Digestive Diseases and Internal Medicine, University of Bologna, Bologna, Italy
    Dig Liver Dis 42:729-34. 2010
    ..Which is the least expensive recall policy for nodules in the cirrhotic liver remains unclear...
  55. ncbi Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine
    Luigi Fiume
    Department of Experimental Pathology, University of Bologna, Via San Giacomo, 14 40126 Bologna, Italy
    J Hepatol 43:645-52. 2005
    ....
  56. ncbi Use of perfusional angiosonography in liver transplantation and conservative management of post-transplant intra-hepatic pseudo-aneurysm
    Fabio Piscaglia
    Division of Internal Medicine Bolondi, Department of Internal Medicine and Gastroenterology, Policlinico S Orsola Malpighi, Via Albertoni 15, 40138 Bologna, Italy
    Transpl Int 17:634-8. 2004
    ..The combination of the two ultrasound techniques was useful in following the course of the pseudo-aneurysm, without further need for angiography. Eventually, this pseudo-aneurysm underwent spontaneous obliteration...
  57. ncbi Partial necrosis on hepatocellular carcinoma nodules facilitates tumor recurrence after liver transplantation
    Matteo Ravaioli
    Department of Liver and Multi-organ Transplantation, Sant'Orsola-Malpighi Hospital, University of Bologna, Italy
    Transplantation 78:1780-6. 2004
    ..CONCLUSION: Partial necrosis was a risk factor for tumor recurrence after liver transplantation. Patients and procedures should be selected while also bearing in mind the side-effect of incomplete necrosis of the nodules...
  58. ncbi Caution in the use of boldo in herbal laxatives: a case of hepatotoxicity
    Fabio Piscaglia
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, IT 40138 Bologna, Italy
    Scand J Gastroenterol 40:236-9. 2005
    ..Transaminases promptly returned to normal after withdrawal of the laxative. It is concluded that boldo leaf extracts might be hepatotoxic, at least in elderly patients with fatty liver...
  59. ncbi Analysis of risk factors for tumor recurrence after liver transplantation for hepatocellular carcinoma: key role of immunosuppression
    Marco Vivarelli
    Department of Surgery and Transplantation, University of Bologna, S Orsola Hospital, Bologna, Italy
    Liver Transpl 11:497-503. 2005
    ..High CsA exposure favors tumor recurrence; CsA blood levels should be kept to the effective minimum in HCC patients. In the presence of pathologic and histologic risk factors, specific immunosuppressive protocols should be considered...
  60. ncbi Characterization of small nodules in cirrhosis by assessment of vascularity: the problem of hypovascular hepatocellular carcinoma
    Luigi Bolondi
    Division of Internal Medicine, Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Hepatology 42:27-34. 2005
    ..Relying on imaging techniques in nodules of 1 to 2 cm would miss the diagnosis of HCC in up to 38% of cases. Any nodule larger than 2 cm should be regarded as highly suspicious for HCC...
  61. ncbi Characterization of focal liver lesions with contrast-enhanced ultrasound
    Fabio Piscaglia
    Division of Internal Medicine, Department of Clinical Medicine, University of Bologna, Bologna, Italy
    Ultrasound Med Biol 36:531-50. 2010
    ....
  62. ncbi Interleukin-1beta and interleukin-6 gene polymorphisms as risk factors for AD: a prospective study
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9 40138 Bologna, Italy
    Exp Gerontol 41:85-92. 2006
    ..The relationship between the AD risk factor plasma tHcy and the IL-1beta-511 polymorphism was never reported before and might explain previous cross-sectional reports of an association between this polymorphism and AD...
  63. ncbi Associations of the -174 G/C interleukin-6 gene promoter polymorphism with serum interleukin 6 and mortality in the elderly
    Giovanni Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Via Massarenti, 9 40138, Bologna, Italy
    Biogerontology 6:415-23. 2005
    ..31, 95%CI: 0.13-0.76]. In conclusion, although associated with increased sIL6 levels in presence of major diseases, the IL6-174 C-allele does not seem to have direct detrimental effects on survival in older age...
  64. ncbi A modeling study of bilirubin kinetics during Molecular Adsorbent Recirculating System sessions
    Elisa Magosso
    Department of Electronics, Computer Science and Systems, University of Bologna, Bologna, Italy
    Artif Organs 30:285-300. 2006
    ..The latter use may allow the investigation of the dependence of these parameters on the operative and clinical conditions, in the effort to arrive at a rationalization and optimization of the treatment...
  65. ncbi Oxidative stress EPR measurement in human liver by radical-probe technique. Correlation with etiology, histology and cell proliferation
    Marco Valgimigli
    Department of Organic Chemistry, University of Bologna, Via S Donato 15, 40127 Bologna, Italy
    Free Radic Res 36:939-48. 2002
    ..ROS overproduction in liver appears to be a common thread linking different pathologic conditions and seems to be influenced by diseases' etiologies...
  66. ncbi Response rate and clinical outcome of HCC after first and repeated cTACE performed "on demand"
    E Terzi
    BLOG Bologna Liver Oncology Group, Sant Orsola Malpighi Hospital, University of Bologna, Bologna, Italy Division of Internal Medicine, Dpt of Digestive Disease and Internal Medicine, Sant Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    J Hepatol 57:1258-67. 2012
    ..Outcome measures were: response rate to first and repeated cTACE, recurrence rates and overall survival...
  67. ncbi Sonographic diagnosis of adult intussusception
    S Sofia
    Dipartimento di Medicina Interna e Gastroenterologia, Divisione di Medicina Interna, Ospedale S. Orsola-Malpighi, Via Albertoni 15, 40128 Bologna, Italy
    Abdom Imaging 26:483-6. 2001
    ..In all cases, the sonographic pattern was typical of intussusception and ultrasonography was the only diagnostic study. Bowel ischemia was not found at surgery in any patient...
  68. ncbi Long term follow-up and outcome of liver transplantation for alcoholic liver disease: a single center case-control study
    Maurizio Biselli
    Department of Clinical Medicine, University of Bologna, Azienda Ospedaliero Universitaria, Policlinico S Orsola Malpighi, Bologna, Italy
    J Clin Gastroenterol 44:52-7. 2010
    ..Alcoholic liver cirrhosis (ALC) is a leading indication for orthotopic liver transplantation (OLT)...
  69. ncbi Selective ablation of Notch3 in HCC enhances doxorubicin's death promoting effect by a p53 dependent mechanism
    Catia Giovannini
    Center for Applied Biomedical Research CRBA, S Orsola Malpighi University Hospital, Bologna, Italy
    J Hepatol 50:969-79. 2009
    ..We previously reported aberrant Notch3 and Notch4 up-regulation in HCC and we have extended these observations to include Notch1...
  70. ncbi Orthotopic liver transplantation (OLT): Contribution of imaging and interventional radiology in preparing the transplantation and managing complications. Part 2: Post-OLT complications and their treatment
    Rita Golfieri
    , Dipartimento Area Radiologica Azienda Ospedaliera di Bologna, Policlinico S. Orsola-Malpighi, , Bologna, Italy
    Radiol Med 110:433-81; quiz 482-3. 2005
  71. ncbi MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells
    Francesca Fornari
    Dipartimento di Medicina Clinica e CRBA, Policlinico S Orsola Malpighi, Bologna, Italy
    Cancer Res 69:5761-7. 2009
    ..Our findings establish a basis toward the development of combined chemo- and miRNA-based therapy for HCC treatment...
  72. ncbi Aberrant Notch3 and Notch4 expression in human hepatocellular carcinoma
    Laura Gramantieri
    Center for Applied Biomedical Research CRBA, University of Bologna and St Orsola Malpighi University Hospital, Bologna, Italy
    Liver Int 27:997-1007. 2007
    ..Notch signalling is altered in several solid tumours and it plays a role in growth inhibition and apoptosis of hepatocellular carcinoma (HCC)-derived cell lines, bile duct development and hepatocyte regeneration...
  73. ncbi In human hepatocellular carcinoma in cirrhosis proliferating cell nuclear antigen (PCNA) is involved in cell proliferation and cooperates with P21 in DNA repair
    Laura Gramantieri
    Center for Applied Biomedical Research CRBA, University of Bologna and St Orsola Malpighi University Hospital, Bologna, Italy
    J Hepatol 39:997-1003. 2003
    ..During DNA-synthesis and repair the only active PCNA fraction is tightly bound to DNA. Similarly, during DNA-repair, a fraction of p21 colocalizes with PCNA in a detergent-insoluble form...
  74. ncbi The intermediate hepatocellular carcinoma stage: Should treatment be expanded?
    Fabio Piscaglia
    Division of Internal Medicine, Dept of Digestive Disease and Internal Medicine, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
    Dig Liver Dis 42:S258-63. 2010
    ..Patients not achieving complete necrosis and patients with early large recurrence should be managed individually, taking into consideration systemic treatments, which usually are reserved for advanced cases...
  75. ncbi MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality
    Laura Gramantieri
    Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
    Clin Cancer Res 15:5073-81. 2009
    ..Deregulated cell proliferation and apoptosis play a major role in hepatocellular carcinoma (HCC). MicroRNAs participate in the modulation of key molecules linked to hepatocarcinogenesis...
  76. ncbi Recent advances in the imaging of hepatocellular carcinoma. From ultrasound to positron emission tomography scan
    Valeria Camaggi
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Saudi Med J 28:1007-14. 2007
    ..A typical vascular pattern in a nodule perceptible also without contrast is highly specific for HCC, so that non-invasive diagnostic algorithms have been developed and recently updated...
  77. ncbi GADD45-alpha expression in cirrhosis and hepatocellular carcinoma: relationship with DNA repair and proliferation
    Laura Gramantieri
    Center for Applied Biomedical Research CRBA, Saint Orsola Malpighi University Hospital, University of Bologna, 40138 Bologna, Italy
    Hum Pathol 36:1154-62. 2005
    ..GADD45-alpha protein levels were higher in HCCs with DNA-bound CDKN1A and PCNA, suggesting a possible role in DNA repair...
  78. ncbi The rational use of albumin in patients with cirrhosis and ascites. A Delphi study for the attainment of a consensus on prescribing standards
    P Gentilini
    Department of Internal Medicine, University of Florence, Vale Morgagni 85, 50134 Florence, Italy
    Dig Liver Dis 36:539-46. 2004
    ..The treatment of this chronic disease usually requires the prolonged use of albumin, frequently continued even after patients' discharge from the hospital...
  79. ncbi Abnormal brain energy metabolism shown by in vivo phosphorus magnetic resonance spectroscopy in patients with chronic liver disease
    B Barbiroli
    Dipartimento di Medicina Clinica e Biotecnologia Applicata D Campanacci, Bologna, Italy
    Brain Res Bull 59:75-82. 2002
    ....
  80. ncbi Liver AL amyloidosis as a possible cause of high liver stiffness values
    Arianna Lanzi
    Division of Internal Medicine Bolondi, Department of Diseases of the Digestive System and Internal Medicine, University of Bologna, Bologna, Italy
    Eur J Gastroenterol Hepatol 22:895-7. 2010
    ..Bone marrow morphology and immunoistochemistry confirmed low-grade plasmacytoma with amyloidosis...
  81. ncbi Human hepatocellular carcinoma expresses specific PCNA isoforms: an in vivo and in vitro evaluation
    Annamaria Venturi
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Lab Invest 88:995-1007. 2008
    ..We conclude that human hepatocellular carcinoma expresses specific PCNA isoforms compared to those found in cirrhosis, implicating a role for PCNA functional alterations in hepatocarcinogenesis...
  82. ncbi MicroRNA involvement in hepatocellular carcinoma
    Laura Gramantieri
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    J Cell Mol Med 12:2189-204. 2008
    ..These findings suggest that miRNAs could become novel molecular targets for HCC treatment. The demonstration of in vivo efficacy and safety of anti-miRNA compounds has opened the way to their use in clinical trials...
  83. ncbi Notch3 intracellular domain accumulates in HepG2 cell line
    Catia Giovannini
    Department of Internal Medicine and Gastroenterology, University of Bologna and S Orsola Malpighi University Hospital, 40138 Bologna, Italy
    Anticancer Res 26:2123-7. 2006
    ..The expression and the functional role of some major components of the Notch signaling pathway in human hepatocellular carcinoma (HCC) are poorly characterized...
  84. ncbi Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma
    Laura Gramantieri
    Dipartimento di Medicina Interna e Gastroenterologia e Centro di Ricerca Biomedica Applicata, Universita di Bologna, Bologna, Italy
    Cancer Res 67:6092-9. 2007
    ..These results indicate that cyclin G1 is a target of miR-122a and expand our knowledge of the molecular alterations involved in HCC pathogenesis and of the role of miRNAs in human cancer...
  85. ncbi Outcomes from a program of home care attendance in very frail elderly subjects
    Raffaele Giannini
    Department of Internal Medicine and Aging, S Orsola Malpighi University Hospital, Via Albertoni 15, 40138 Bologna, Italy
    Arch Gerontol Geriatr 44:95-103. 2007
    ..These outcomes can be related to the additional program of home attendance. The correlation between pro-inflammatory cytokine levels and degree of frailty are observed in both groups without statistically significant difference...
  86. ncbi Cirrhosis does not shift the circadian phase of plasma fibrinolysis
    Fabio Piscaglia
    Department of Internal Medicine and Gastroenterology, University of Bologna, Italy
    Am J Gastroenterol 97:1512-7. 2002
    ....
  87. ncbi Contrast-enhanced ultrasound in the diagnosis of hepatocellular carcinoma
    Riccardo Lencioni
    Division of Diagnostic and Interventional Radiology, Department of Oncology, Transplants, and Advanced Technologies in Medicine, Cisanello University Hospital, Via Paradisa 2, University of Pisa, Pisa, Italy
    J Hepatol 48:848-57. 2008
    ..Hence, CT or MR imaging are still mandatory for proper intrahepatic staging of the disease...
  88. ncbi Screening tests for hepatocellular carcinoma
    Luigi Bolondi
    Hepatology 37:1493; author reply 1493. 2003
  89. ncbi Hepatocellular carcinoma: epidemiology and clinical aspects
    Roberto Mazzanti
    Department of Oncology, Azienda Ospedaliero Universitaria Careggi, Istituto Toscano Tumori, University of Florence, Florence, Italy
    Mol Aspects Med 29:130-43. 2008
    ..In this review authors report the most recent findings on the pathogenesis of liver cancer and on therapeutic approaches, included those emerging from the most recent literature...
  90. ncbi Selecting patients with hepatocellular carcinoma for transplantation
    Fabio Piscaglia
    Liver Transpl 13:1203; author reply 1204. 2007
  91. ncbi Sorafenib in advanced hepatocellular carcinoma
    Josep M Llovet
    Barcelona Clinic Liver Cancer Group, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigaciones en Red de Enfermedades Hepáticas y Digestivas Hospital Clínic Barcelona, Barcelona
    N Engl J Med 359:378-90. 2008
    ..A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor, the platelet-derived growth factor receptor, and Raf may be effective in hepatocellular carcinoma...
  92. ncbi Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood
    Silvia Sabbioni
    Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
    Mol Diagn 7:201-7. 2003
    ....
  93. ncbi Onset of bronchiolitis obliterans organizing pneumonia in a liver transplant recipient under peg-interferon and ribavirin treatment
    Cristina Crespi
    Intern Emerg Med 3:77-80. 2008
  94. ncbi Portal pressure and Doppler
    Fabio Piscaglia
    Ultrasound Med Biol 29:495-6. 2003
  95. ncbi Squamous cell carcinoma of the liver: metastasis or primary neoplasm?
    Silvia Bondini
    J Clin Ultrasound 33:477-8. 2005
  96. ncbi A case of intractable pruritus in Turner's syndrome successfully treated with molecular adsorbent recirculating system
    Elena Silvagni
    Intern Emerg Med 3:65-7. 2008