Research Topics
Species | Geremia B BolliSummaryAffiliation: University of Perugia Country: Italy Publications
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Publications
Administration of neutral protamine Hagedorn insulin at bedtime versus with dinner in type 1 diabetes mellitus to avoid nocturnal hypoglycemia and improve control. A randomized, controlled trialCarmine G Fanelli
Department of Internal Medicine, University of Perugia, Via E. Dal Pozzo, I-06126 Perugia, Italy
Ann Intern Med 136:504-14. 2002....- Insulin treatment in type 1 diabetesGeremia B Bolli
Department of Medicine, University of Perugia, Italy
Endocr Pract 12:105-9. 2006..Clinicians should prescribe insulin regimens that yield physiologic results in patients with type 1 diabetes... 
Plasma exposure to insulin glargine and its metabolites M1 and M2 after subcutaneous injection of therapeutic and supratherapeutic doses of glargine in subjects with type 1 diabetesGeremia B Bolli
Department of Internal Medicine, University of Perugia, Perugia, Italy
Diabetes Care 35:2626-30. 2012..The aim of the study was to quantitate plasma concentrations of glargine, M1, and M2 after subcutaneous injection of glargine in male type 1 diabetic subjects...
Lower fasting blood glucose, glucose variability and nocturnal hypoglycaemia with glargine vs NPH basal insulin in subjects with Type 1 diabetesG B Bolli
Department of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Italy
Nutr Metab Cardiovasc Dis 19:571-9. 2009..Secondary objectives included self-monitoring blood glucose, mean daily blood glucose (MDBG) and mean amplitude glucose excursion (MAGE) values alongside changes in HbA(1c) and safety profiles...- Recovery and prevention of hypoglycaemia unawareness in type 1 diabetes mellitusG B Bolli
Department of Internal Medicine, University of Perugia, Perugia, Italy
Diabetes Nutr Metab 15:402-9; discussion 409. 2002 - Comparison of a multiple daily insulin injection regimen (basal once-daily glargine plus mealtime lispro) and continuous subcutaneous insulin infusion (lispro) in type 1 diabetes: a randomized open parallel multicenter studyGeremia B Bolli
Department of Internal Medicine, University of Perugia, Perugia, Italy
Diabetes Care 32:1170-6. 2009..We aimed to help close that deficiency... - Rational use of insulin analogues in the treatment of type 1 diabetes mellitusGeremia B Bolli
University of Perugia, Section of Internal Medicine, Endocrinology and Metabolism, Perugia, Italy
Pediatr Endocrinol Rev 1:9-21. 2003..As compared to NPH, glargine reduces the risk for nocturnal hypoglycaemia, and at the same time improves HbA1c similarly to CSII... - International Forum for the Advancement of Diabetes Research and Care, April 29-30, 2011, Athens, GreeceGeremia B Bolli
Department of Medicine, University of Perugia, Perugia, Italy
Diabetes Technol Ther 13:967-79. 2011..The meeting represented an excellent forum for the presentation of new research and the exchange of ideas aimed at improving outcomes for people with diabetes... - Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysisPaola Lucidi
Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
Diabetes 59:1349-57. 2010..However, it is not known whether FFA plays a role in the development of posthypoglycemic insulin resistance as well... - Effect of oral amino acids on counterregulatory responses and cognitive function during insulin-induced hypoglycemia in nondiabetic and type 1 diabetic peoplePaolo Rossetti
Department of Internal Medicine, University of Perugia, Perugia, Italy
Diabetes 57:1905-17. 2008..The aim of this study was to assess the responses to hypoglycemia in nondiabetic and type 1 diabetic subjects after ingestion of an amino acid mixture... - Portal vein glucose sensors do not play a major role in modulating physiological responses to insulin-induced hypoglycemia in humansPaolo Rossetti
Department of Internal Medicine, University of Perugia, Perugia, Italy
Diabetes 58:194-202. 2009..The aim of the present study was to examine in humans the potential role of portal vein glucose sensors in physiological responses to insulin-induced hypoglycemia mimicking the slow fall of insulin-treated diabetic subjects... - Insulin is required for prandial ghrelin suppression in humansGiuseppe Murdolo
Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences IMISEM, University of Perugia, Perugia, Italy
Diabetes 52:2923-7. 2003..lack of meal-induced ghrelin suppression caused by severe insulin deficiency may explain hyperphagia of uncontrolled type 1 diabetic subjects... - Metabolic and endocrine effects of physiological increments in plasma ghrelin concentrationsPaola Lucidi
Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences (I.M.I.S.E.M, University of Perugia, Via Enrico Dal Pozzo, 06126 Perugia, Italy
Nutr Metab Cardiovasc Dis 15:410-7. 2005.... - Comparison of pharmacokinetics and dynamics of the long-acting insulin analogs glargine and detemir at steady state in type 1 diabetes: a double-blind, randomized, crossover studyFrancesca Porcellati
Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
Diabetes Care 30:2447-52. 2007..4 +/- 1.6 kg/m2, and A1C 7.2 +/- 0.7%) were studied after a 2-week treatment with either glargine or detemir once daily (randomized, double-blind, crossover study)... - Differential effects of adiposity on pharmacodynamics of basal insulins NPH, glargine, and detemir in type 2 diabetes mellitusFrancesca Porcellati
Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
Diabetes Care 34:2521-3. 2011.... - Intensive replacement of basal insulin in patients with type 1 diabetes given rapid-acting insulin analog at mealtime: a 3-month comparison between administration of NPH insulin four times daily and glargine insulin at dinner or bedtimePaolo Rossetti
Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Italy
Diabetes Care 26:1490-6. 2003..In contrast to NPH, which should be given at bedtime, insulin glargine can be administered at dinnertime without deteriorating blood glucose control... - Pharmacokinetics and pharmacodynamics of therapeutic doses of basal insulins NPH, glargine, and detemir after 1 week of daily administration at bedtime in type 2 diabetic subjects: a randomized cross-over studyPaola Lucidi
Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
Diabetes Care 34:1312-4. 2011..To compare the pharmacokinetics and pharmacodynamics of NPH, glargine, and detemir insulins in type 2 diabetic subjects... - Pharmacokinetics and pharmacodynamics of the long-acting insulin analog glargine after 1 week of use compared with its first administration in subjects with type 1 diabetesFrancesca Porcellati
University of Perugia, Department of Internal Medicine, Section of Internal Medicine, Endocrinology, and Metabolism, Via E. Dal Pozzo, 06126 Perugia, Italy
Diabetes Care 30:1261-3. 2007 - Counterregulatory hormone and symptom responses to insulin-induced hypoglycemia in the postprandial state in humansFrancesca Porcellati
Section of Internal Medicine, University of Perugia, Perugia, Italy
Diabetes 52:2774-83. 2003..In conclusion, in the postprandial compared with the fasting hypoglycemic state, total symptoms are less, but counterregulatory hormones are greater and responses of glucagon nearly normalize in type 1 diabetic subjects... - Short-term effects of the long-acting insulin analog detemir and human insulin on plasma levels of insulin-like growth factor-I and its binding proteins in humansFrancesca Porcellati
University of Perugia, Department of Internal Medicine, Via E dal Pozzo, Perugia, Italy
J Clin Endocrinol Metab 94:3017-24. 2009.... - Metabolism of insulin glargine after repeated daily subcutaneous injections in subjects with type 2 diabetesPaola Lucidi
Internal Medicine, University of Perugia, Perugia, Italy
Diabetes Care 35:2647-9. 2012..To investigate concentration of plasma insulin glargine after its subcutaneous dosing compared with concentration of its metabolites 1 (M1) and 2 (M2) in subjects with type 2 diabetes... - Different brain responses to hypoglycemia induced by equipotent doses of the long-acting insulin analog detemir and human regular insulin in humansPaolo Rossetti
Department of Internal Medicine, Endocrinology, and Metabolism, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
Diabetes 57:746-56. 2008..The aim of these studies was to assess the brain/hypothalamus responses to euglycemia and hypoglycemia in humans during intravenous infusion of equipotent doses of detemir and human insulin... - Prevention of hypoglycemia while achieving good glycemic control in type 1 diabetes: the role of insulin analogsPaolo Rossetti
Department of Internal Medicine, University of Perugia, Perugia, Italy
Diabetes Care 31:S113-20. 2008 - Better long-term glycaemic control with the basal insulin glargine as compared with NPH in patients with Type 1 diabetes mellitus given meal-time lispro insulinF Porcellati
Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Via E. Dal Pozzo, I-06126 Perugia, Italy
Diabet Med 21:1213-20. 2004..Thus, glargine appears more suitable than NPH as basal insulin for intensive treatment of T1 DM... - Superiority of insulin analogues versus human insulin in the treatment of diabetes mellitusPaolo Rossetti
Department of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Via E dal Pozzo, Perugia, Italy
Arch Physiol Biochem 114:3-10. 2008..Rapid- and long-acting insulin analogues should always be combined in the treatment of T1 and T2DM... - Insulin therapy and hypoglycaemia: the size of the problemCarmine G Fanelli
Section of Internal Medicine, University of Perugia, Italy
Diabetes Metab Res Rev 20:S32-42. 2004..Finally, hypoglycaemia may be fatal. Hypoglycaemia induced by insulin as treatment of type 1 diabetes mellitus (T1 DM) is not the consequence of diabetes, but invariably of the non-physiological replacement of insulin... - Treatment and prevention of hypoglycemia and its unawareness in type 1 diabetes mellitusGeremia B Bolli
Department of Internal Medicine, University of Perugia, Italy
Rev Endocr Metab Disord 4:335-41. 2003 - Hyperglycemia-induced platelet activation in type 2 diabetes is resistant to aspirin but not to a nitric oxide-donating agentPaolo Gresele
Section of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
Diabetes Care 33:1262-8. 2010..Our aim was to assess comparatively the effect of aspirin, a nitric oxide-donating agent (NCX 4016), their combination, or placebo on platelet activation induced by acute hyperglycemia in type 2 diabetes... - Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemiaPaola Lucidi
Department of Internal Medicine, Section Internal Medicine, Endocrine and Metabolic Sciences, University of Perugia, Italy
Diabetes 51:2911-4. 2002..These results raise the possibility that postprandial hyperinsulinemia is responsible for the reduction of plasma ghrelin that occurs during meal intake... - Long-term intervention studies using insulin in patients with type 1 diabetesGeremia B Bolli
Department of Medicine, University of Perugia, Italy
Endocr Pract 12:80-4. 2006..Therefore, safe achievement and maintenance of target glycemic goals are possible... - Pharmacokinetics and pharmacodynamics of basal insulinsFrancesca Porcellati
Department of Internal Medicine, University of Perugia, Perugia, Italy
Diabetes Technol Ther 13:S15-24. 2011..These differences should be taken into consideration when the individual analogs are introduced to provide basal insulin supplementation to optimize blood glucose control in patients with type 1 and type 2 diabetes as well... - Optimizing the replacement of basal insulin in type 1 diabetes mellitus: no longer an elusive goal in the post-NPH eraGeremia B Bolli
Section of Internal Medicine, Endocrinology and Metabolism, Department of Internal Medicine, University of Perugia, Perugia, Italy
Diabetes Technol Ther 13:S43-52. 2011.... - Type 1 diabetes mellitus: effective insulin strategies with less hypoglycemiaGeremia B Bolli
Sezione di Medicina Interna, Universita di Perugia, 06126 Perugia, Italy
Postgrad Med 116:13-20. 2004..Insulin glargine reduces the frequency of nocturnal hypoglycemia compared with NPH when used with rapid-acting analogues and thus facilitates optimal insulin replacement therapy... - Hypoglycaemia unawarenessG B Bolli
University of Perugia, Italy
Diabetes Metab 23:29-35. 1997..Under these conditions, IDDM patients can maintain the warning symptoms and adrenaline response to hypoglycaemia, ensuring a vital backup system for safe intensive therapy of IDDM... - How to ameliorate the problem of hypoglycemia in intensive as well as nonintensive treatment of type 1 diabetesG B Bolli
Department of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Italy
Diabetes Care 22:B43-52. 1999..Importantly, a program of meticulous prevention of hypoglycemia does not result in loss of long-term near-normoglycemia, i.e., it is compatible with the glycemic targets of intensive therapy... - Rate of fall of blood glucose and physiological responses of counterregulatory hormones, clinical symptoms and cognitive function to hypoglycaemia in Type I diabetes mellitus in the postprandial stateC G Fanelli
University of Perugia, Department of Internal Medicine, Perugia, Italy
Diabetologia 46:53-64. 2003.... - Physiological insulin replacement in type 1 diabetes mellitusG B Bolli
Department of Internal Medicine, University of Perugia, Italy
Exp Clin Endocrinol Diabetes 109:S317-32. 2001..Insulin glargine reproduces closely the pharmacokinetics and pharmacodynamics of continuous s.c. insulin infusion, and should always be preferred to NPH in all insulin-requiring diabetic patients, both type 1 and type 2... - Physiology of glucose counterregulation to hypoglycemiaG B Bolli
Department of Internal Medicine, Endocrinology, and Metabolism, University of Perugia, Italy
Endocrinol Metab Clin North Am 28:467-93, v. 1999..The first response is known as counterregulation, a system that prevents and corrects hypoglycemia through the release of counterregulatory hormones... - Effect of the amino acid alanine on glucagon secretion in non-diabetic and type 1 diabetic subjects during hyperinsulinaemic euglycaemia, hypoglycaemia and post-hypoglycaemic hyperglycaemiaF Porcellati
Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126, Perugia, Italy
Diabetologia 50:422-30. 2007..The aim of our study was to establish whether the well-known defective or absent secretion of glucagon in type 1 diabetes in response to hypoglycaemia is selective or includes lack of responses to other stimuli, such as amino acids... - Glucagon: the effects of its excess and deficiency on insulin actionC G Fanelli
Department of Internal Medicine, Section of Endocrinology and Metabolism, University of Perugia, Via E. Dal Pozzo, I-06126 Perugia, Italy
Nutr Metab Cardiovasc Dis 16:S28-34. 2006..It is expected that drugs that are able to reduce glucagon secretion in concert with strategies directed to recover glucagon secretion to hypoglycaemia might contribute to improve the overall glycaemic control in diabetes... - Acute, short-term hyperglycemia enhances shear stress-induced platelet activation in patients with type II diabetes mellitusPaolo Gresele
Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, snc 06126, Perugia, Italy
J Am Coll Cardiol 41:1013-20. 2003..The aim of our study was to assess whether acute, short-term hyperglycemia affects platelet reactivity in patients with Type II diabetes mellitus (T2DM)... - Adrenaline vs glucagon in the primacy of glucose counterregulationP De Feo
Department of Internal Medicine, University of Perugia, Perugia, Italy
Diabetes Nutr Metab 15:323-7; discussion 328. 2002 - Evaluation of the accuracy of a microdialysis-based glucose sensor during insulin-induced hypoglycemia, its recovery, and post-hypoglycemic hyperglycemia in humansP Rossetti
Department of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
Diabetes Technol Ther 8:326-37. 2006..However, these results can be achieved only if calibration of the GlucoDay is performed under conditions of sensor signal stability. Similar studies have to be performed in subjects with diabetes to validate the GlucoDay system... - Effects of whole-body vibration exercise on the endocrine system of healthy menC Di Loreto
Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences (IMISEM, University of Perugia, Perugia, Italy
J Endocrinol Invest 27:323-7. 2004..Since hormonal responses, with the exception of norepinephrine, are not affected by acute vibration exposure, this type of exercise is not expected to reduce fat mass in obese subjects... - The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy womenElza Muscelli
Department of Internal Medicine, University of Pisa, Pisa, Italy
Am J Hypertens 22:364-70. 2009.... - Fluctuation of serum basal insulin levels following single and multiple dosing of insulin glargineJohn Gerich
University of Rochester Medical Center, Rochester, New York, USA
Diabetes Technol Ther 8:237-43. 2006..This lower fluctuation of glargine over NPH or ultralente can help to reduce hyper- or hypoglycemia risks associated with insulin therapy and accordingly encourage achievement of better blood glucose control... - Glucose variability and complicationsGeremia B Bolli
Diabetes Care 29:1707-9. 2006 - Insulin- and exercise-stimulated skeletal muscle blood flow and glucose uptake in obese menKirsti Hallsten
Turku PET Centre and Department of Medicine, University of Helsinki, Finland Department of Medicine, University of Turku, Finland
Obes Res 11:257-65. 2003..g., skeletal muscle. In the present study, we determined whether insulin resistance in obesity is associated with an impaired ability of exercise to stimulate muscle blood flow, oxygen delivery, or glucose uptake... - Establishing the deficiency of glucagon response to hypoglycemia in humansGeremia B Bolli
Endocr Pract 9:164-5. 2003