Geremia B Bolli

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. ncbi request reprint Administration of neutral protamine Hagedorn insulin at bedtime versus with dinner in type 1 diabetes mellitus to avoid nocturnal hypoglycemia and improve control. A randomized, controlled trial
    Carmine G Fanelli
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
    Ann Intern Med 136:504-14. 2002
  2. ncbi request reprint Insulin treatment in type 1 diabetes
    Geremia B Bolli
    Department of Medicine, University of Perugia, Italy
    Endocr Pract 12:105-9. 2006
  3. ncbi request reprint Treatment and prevention of hypoglycemia and its unawareness in type 1 diabetes mellitus
    Geremia B Bolli
    Department of Internal Medicine, University of Perugia, Italy
    Rev Endocr Metab Disord 4:335-41. 2003
  4. pmc Plasma exposure to insulin glargine and its metabolites M1 and M2 after subcutaneous injection of therapeutic and supratherapeutic doses of glargine in subjects with type 1 diabetes
    Geremia B Bolli
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Care 35:2626-30. 2012
  5. doi request reprint Lower fasting blood glucose, glucose variability and nocturnal hypoglycaemia with glargine vs NPH basal insulin in subjects with Type 1 diabetes
    G B Bolli
    Department of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Italy
    Nutr Metab Cardiovasc Dis 19:571-9. 2009
  6. pmc Comparison of a multiple daily insulin injection regimen (basal once-daily glargine plus mealtime lispro) and continuous subcutaneous insulin infusion (lispro) in type 1 diabetes: a randomized open parallel multicenter study
    Geremia B Bolli
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Care 32:1170-6. 2009
  7. pmc International Forum for the Advancement of Diabetes Research and Care, April 29-30, 2011, Athens, Greece
    Geremia B Bolli
    Department of Medicine, University of Perugia, Perugia, Italy
    Diabetes Technol Ther 13:967-79. 2011
  8. ncbi request reprint Rational use of insulin analogues in the treatment of type 1 diabetes mellitus
    Geremia B Bolli
    University of Perugia, Section of Internal Medicine, Endocrinology and Metabolism, Perugia, Italy
    Pediatr Endocrinol Rev 1:9-21. 2003
  9. ncbi request reprint Recovery and prevention of hypoglycaemia unawareness in type 1 diabetes mellitus
    G B Bolli
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Nutr Metab 15:402-9; discussion 409. 2002
  10. pmc Effect of oral amino acids on counterregulatory responses and cognitive function during insulin-induced hypoglycemia in nondiabetic and type 1 diabetic people
    Paolo Rossetti
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes 57:1905-17. 2008

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Administration of neutral protamine Hagedorn insulin at bedtime versus with dinner in type 1 diabetes mellitus to avoid nocturnal hypoglycemia and improve control. A randomized, controlled trial
    Carmine G Fanelli
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
    Ann Intern Med 136:504-14. 2002
    ..Intensive insulin treatment of type 1 diabetes mellitus increases the risk for nocturnal hypoglycemia...
  2. ncbi request reprint Insulin treatment in type 1 diabetes
    Geremia B Bolli
    Department of Medicine, University of Perugia, Italy
    Endocr Pract 12:105-9. 2006
    ..To present key aspects and strategies for use of insulin therapy in patients with type 1 diabetes mellitus...
  3. ncbi request reprint Treatment and prevention of hypoglycemia and its unawareness in type 1 diabetes mellitus
    Geremia B Bolli
    Department of Internal Medicine, University of Perugia, Italy
    Rev Endocr Metab Disord 4:335-41. 2003
  4. pmc Plasma exposure to insulin glargine and its metabolites M1 and M2 after subcutaneous injection of therapeutic and supratherapeutic doses of glargine in subjects with type 1 diabetes
    Geremia B Bolli
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Care 35:2626-30. 2012
    ..The aim of the study was to quantitate plasma concentrations of glargine, M1, and M2 after subcutaneous injection of glargine in male type 1 diabetic subjects...
  5. doi request reprint Lower fasting blood glucose, glucose variability and nocturnal hypoglycaemia with glargine vs NPH basal insulin in subjects with Type 1 diabetes
    G B Bolli
    Department of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Italy
    Nutr Metab Cardiovasc Dis 19:571-9. 2009
    ..Secondary objectives included self-monitoring blood glucose, mean daily blood glucose (MDBG) and mean amplitude glucose excursion (MAGE) values alongside changes in HbA(1c) and safety profiles...
  6. pmc Comparison of a multiple daily insulin injection regimen (basal once-daily glargine plus mealtime lispro) and continuous subcutaneous insulin infusion (lispro) in type 1 diabetes: a randomized open parallel multicenter study
    Geremia B Bolli
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Care 32:1170-6. 2009
    ..We aimed to help close that deficiency...
  7. pmc International Forum for the Advancement of Diabetes Research and Care, April 29-30, 2011, Athens, Greece
    Geremia B Bolli
    Department of Medicine, University of Perugia, Perugia, Italy
    Diabetes Technol Ther 13:967-79. 2011
    ..The meeting represented an excellent forum for the presentation of new research and the exchange of ideas aimed at improving outcomes for people with diabetes...
  8. ncbi request reprint Rational use of insulin analogues in the treatment of type 1 diabetes mellitus
    Geremia B Bolli
    University of Perugia, Section of Internal Medicine, Endocrinology and Metabolism, Perugia, Italy
    Pediatr Endocrinol Rev 1:9-21. 2003
    ..As compared to NPH, glargine reduces the risk for nocturnal hypoglycaemia, and at the same time improves HbA1c similarly to CSII...
  9. ncbi request reprint Recovery and prevention of hypoglycaemia unawareness in type 1 diabetes mellitus
    G B Bolli
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Nutr Metab 15:402-9; discussion 409. 2002
  10. pmc Effect of oral amino acids on counterregulatory responses and cognitive function during insulin-induced hypoglycemia in nondiabetic and type 1 diabetic people
    Paolo Rossetti
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes 57:1905-17. 2008
    ..The aim of this study was to assess the responses to hypoglycemia in nondiabetic and type 1 diabetic subjects after ingestion of an amino acid mixture...
  11. pmc Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis
    Paola Lucidi
    Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
    Diabetes 59:1349-57. 2010
    ..However, it is not known whether FFA plays a role in the development of posthypoglycemic insulin resistance as well...
  12. pmc Portal vein glucose sensors do not play a major role in modulating physiological responses to insulin-induced hypoglycemia in humans
    Paolo Rossetti
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes 58:194-202. 2009
    ..The aim of the present study was to examine in humans the potential role of portal vein glucose sensors in physiological responses to insulin-induced hypoglycemia mimicking the slow fall of insulin-treated diabetic subjects...
  13. ncbi request reprint Insulin is required for prandial ghrelin suppression in humans
    Giuseppe Murdolo
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences IMISEM, University of Perugia, Perugia, Italy
    Diabetes 52:2923-7. 2003
    ..lack of meal-induced ghrelin suppression caused by severe insulin deficiency may explain hyperphagia of uncontrolled type 1 diabetic subjects...
  14. ncbi request reprint Metabolic and endocrine effects of physiological increments in plasma ghrelin concentrations
    Paola Lucidi
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences I M I S E M, University of Perugia, Via Enrico Dal Pozzo, 06126 Perugia, Italy
    Nutr Metab Cardiovasc Dis 15:410-7. 2005
    ..At present, it is not known whether physiological increments in plasma ghrelin concentrations affect glucose kinetics or hormone concentrations in humans...
  15. ncbi request reprint Comparison of pharmacokinetics and dynamics of the long-acting insulin analogs glargine and detemir at steady state in type 1 diabetes: a double-blind, randomized, crossover study
    Francesca Porcellati
    Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Diabetes Care 30:2447-52. 2007
    ..4 +/- 1.6 kg/m2, and A1C 7.2 +/- 0.7%) were studied after a 2-week treatment with either glargine or detemir once daily (randomized, double-blind, crossover study)...
  16. pmc Differential effects of adiposity on pharmacodynamics of basal insulins NPH, glargine, and detemir in type 2 diabetes mellitus
    Francesca Porcellati
    Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
    Diabetes Care 34:2521-3. 2011
    ....
  17. ncbi request reprint Intensive replacement of basal insulin in patients with type 1 diabetes given rapid-acting insulin analog at mealtime: a 3-month comparison between administration of NPH insulin four times daily and glargine insulin at dinner or bedtime
    Paolo Rossetti
    Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Italy
    Diabetes Care 26:1490-6. 2003
    ..e., NPH injected four times a day versus glargine insulin once daily at dinner or at bedtime...
  18. pmc Pharmacokinetics and pharmacodynamics of therapeutic doses of basal insulins NPH, glargine, and detemir after 1 week of daily administration at bedtime in type 2 diabetic subjects: a randomized cross-over study
    Paola Lucidi
    Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
    Diabetes Care 34:1312-4. 2011
    ..To compare the pharmacokinetics and pharmacodynamics of NPH, glargine, and detemir insulins in type 2 diabetic subjects...
  19. ncbi request reprint Pharmacokinetics and pharmacodynamics of the long-acting insulin analog glargine after 1 week of use compared with its first administration in subjects with type 1 diabetes
    Francesca Porcellati
    University of Perugia, Department of Internal Medicine, Section of Internal Medicine, Endocrinology, and Metabolism, Via E dal Pozzo, 06126 Perugia, Italy
    Diabetes Care 30:1261-3. 2007
  20. ncbi request reprint Counterregulatory hormone and symptom responses to insulin-induced hypoglycemia in the postprandial state in humans
    Francesca Porcellati
    Section of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes 52:2774-83. 2003
    ..In conclusion, in the postprandial compared with the fasting hypoglycemic state, total symptoms are less, but counterregulatory hormones are greater and responses of glucagon nearly normalize in type 1 diabetic subjects...
  21. doi request reprint Short-term effects of the long-acting insulin analog detemir and human insulin on plasma levels of insulin-like growth factor-I and its binding proteins in humans
    Francesca Porcellati
    University of Perugia, Department of Internal Medicine, Via E dal Pozzo, Perugia, Italy
    J Clin Endocrinol Metab 94:3017-24. 2009
    ....
  22. pmc Metabolism of insulin glargine after repeated daily subcutaneous injections in subjects with type 2 diabetes
    Paola Lucidi
    Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Care 35:2647-9. 2012
    ..To investigate concentration of plasma insulin glargine after its subcutaneous dosing compared with concentration of its metabolites 1 (M1) and 2 (M2) in subjects with type 2 diabetes...
  23. ncbi request reprint Different brain responses to hypoglycemia induced by equipotent doses of the long-acting insulin analog detemir and human regular insulin in humans
    Paolo Rossetti
    Department of Internal Medicine, Endocrinology, and Metabolism, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Diabetes 57:746-56. 2008
    ..The aim of these studies was to assess the brain/hypothalamus responses to euglycemia and hypoglycemia in humans during intravenous infusion of equipotent doses of detemir and human insulin...
  24. doi request reprint Prevention of hypoglycemia while achieving good glycemic control in type 1 diabetes: the role of insulin analogs
    Paolo Rossetti
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Care 31:S113-20. 2008
  25. ncbi request reprint Better long-term glycaemic control with the basal insulin glargine as compared with NPH in patients with Type 1 diabetes mellitus given meal-time lispro insulin
    F Porcellati
    Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
    Diabet Med 21:1213-20. 2004
    ..The aim of this study was to test superiority of glargine on long-term blood glucose (BG) as well as on responses to hypoglycaemia vs. NPH...
  26. ncbi request reprint Superiority of insulin analogues versus human insulin in the treatment of diabetes mellitus
    Paolo Rossetti
    Department of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Via E dal Pozzo, Perugia, Italy
    Arch Physiol Biochem 114:3-10. 2008
    ..Rapid- and long-acting insulin analogues should always be combined in the treatment of T1 and T2DM...
  27. ncbi request reprint Insulin therapy and hypoglycaemia: the size of the problem
    Carmine G Fanelli
    Section of Internal Medicine, University of Perugia, Italy
    Diabetes Metab Res Rev 20:S32-42. 2004
    ..Finally, hypoglycaemia may be fatal. Hypoglycaemia induced by insulin as treatment of type 1 diabetes mellitus (T1 DM) is not the consequence of diabetes, but invariably of the non-physiological replacement of insulin...
  28. pmc Hyperglycemia-induced platelet activation in type 2 diabetes is resistant to aspirin but not to a nitric oxide-donating agent
    Paolo Gresele
    Section of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Care 33:1262-8. 2010
    ..Our aim was to assess comparatively the effect of aspirin, a nitric oxide-donating agent (NCX 4016), their combination, or placebo on platelet activation induced by acute hyperglycemia in type 2 diabetes...
  29. ncbi request reprint Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia
    Paola Lucidi
    Department of Internal Medicine, Section Internal Medicine, Endocrine and Metabolic Sciences, University of Perugia, Italy
    Diabetes 51:2911-4. 2002
    ..These results raise the possibility that postprandial hyperinsulinemia is responsible for the reduction of plasma ghrelin that occurs during meal intake...
  30. ncbi request reprint Long-term intervention studies using insulin in patients with type 1 diabetes
    Geremia B Bolli
    Department of Medicine, University of Perugia, Italy
    Endocr Pract 12:80-4. 2006
    ..To discuss data from long-term intervention studies regarding therapy in type 1 diabetes and review strategies for preventing hypoglycemia and safely achieving glycemic goals in this patient population...
  31. doi request reprint Pharmacokinetics and pharmacodynamics of basal insulins
    Francesca Porcellati
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Technol Ther 13:S15-24. 2011
    ..These differences should be taken into consideration when the individual analogs are introduced to provide basal insulin supplementation to optimize blood glucose control in patients with type 1 and type 2 diabetes as well...
  32. doi request reprint Optimizing the replacement of basal insulin in type 1 diabetes mellitus: no longer an elusive goal in the post-NPH era
    Geremia B Bolli
    Section of Internal Medicine, Endocrinology and Metabolism, Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Technol Ther 13:S43-52. 2011
    ....
  33. doi request reprint Type 1 diabetes mellitus: effective insulin strategies with less hypoglycemia
    Geremia B Bolli
    Sezione di Medicina Interna, Universita di Perugia, 06126 Perugia, Italy
    Postgrad Med 116:13-20. 2004
    ..Insulin glargine reduces the frequency of nocturnal hypoglycemia compared with NPH when used with rapid-acting analogues and thus facilitates optimal insulin replacement therapy...
  34. ncbi request reprint Physiology of glucose counterregulation to hypoglycemia
    G B Bolli
    Department of Internal Medicine, Endocrinology, and Metabolism, University of Perugia, Italy
    Endocrinol Metab Clin North Am 28:467-93, v. 1999
    ..The first response is known as counterregulation, a system that prevents and corrects hypoglycemia through the release of counterregulatory hormones...
  35. ncbi request reprint Rate of fall of blood glucose and physiological responses of counterregulatory hormones, clinical symptoms and cognitive function to hypoglycaemia in Type I diabetes mellitus in the postprandial state
    C G Fanelli
    University of Perugia, Department of Internal Medicine, Perugia, Italy
    Diabetologia 46:53-64. 2003
    ..e. release of counterregulatory hormones, perception of symptoms, deterioration of cognitive function, and rates of forearm noradrenaline spillover, in the postprandial condition and in the sitting position...
  36. ncbi request reprint How to ameliorate the problem of hypoglycemia in intensive as well as nonintensive treatment of type 1 diabetes
    G B Bolli
    Department of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Italy
    Diabetes Care 22:B43-52. 1999
    ..Importantly, a program of meticulous prevention of hypoglycemia does not result in loss of long-term near-normoglycemia, i.e., it is compatible with the glycemic targets of intensive therapy...
  37. ncbi request reprint Hypoglycaemia unawareness
    G B Bolli
    University of Perugia, Italy
    Diabetes Metab 23:29-35. 1997
    ..Under these conditions, IDDM patients can maintain the warning symptoms and adrenaline response to hypoglycaemia, ensuring a vital backup system for safe intensive therapy of IDDM...
  38. ncbi request reprint Physiological insulin replacement in type 1 diabetes mellitus
    G B Bolli
    Department of Internal Medicine, University of Perugia, Italy
    Exp Clin Endocrinol Diabetes 109:S317-32. 2001
    ..Insulin glargine reproduces closely the pharmacokinetics and pharmacodynamics of continuous s.c. insulin infusion, and should always be preferred to NPH in all insulin-requiring diabetic patients, both type 1 and type 2...
  39. ncbi request reprint Glucagon: the effects of its excess and deficiency on insulin action
    C G Fanelli
    Department of Internal Medicine, Section of Endocrinology and Metabolism, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
    Nutr Metab Cardiovasc Dis 16:S28-34. 2006
    ..To review the role that glucagon plays in physiology, physiopathology and clinical medicine...
  40. ncbi request reprint Effect of the amino acid alanine on glucagon secretion in non-diabetic and type 1 diabetic subjects during hyperinsulinaemic euglycaemia, hypoglycaemia and post-hypoglycaemic hyperglycaemia
    F Porcellati
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, 06126, Perugia, Italy
    Diabetologia 50:422-30. 2007
    ..The aim of our study was to establish whether the well-known defective or absent secretion of glucagon in type 1 diabetes in response to hypoglycaemia is selective or includes lack of responses to other stimuli, such as amino acids...
  41. ncbi request reprint Acute, short-term hyperglycemia enhances shear stress-induced platelet activation in patients with type II diabetes mellitus
    Paolo Gresele
    Division of Internal and Cardiovascular Medicine, Department of Internal Medicine, University of Perugia, Via E dal Pozzo, snc 06126, Perugia, Italy
    J Am Coll Cardiol 41:1013-20. 2003
    ..The aim of our study was to assess whether acute, short-term hyperglycemia affects platelet reactivity in patients with Type II diabetes mellitus (T2DM)...
  42. ncbi request reprint Evaluation of the accuracy of a microdialysis-based glucose sensor during insulin-induced hypoglycemia, its recovery, and post-hypoglycemic hyperglycemia in humans
    P Rossetti
    Department of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
    Diabetes Technol Ther 8:326-37. 2006
    ..Menarini Diagnostics, Firenze, Italy) compared with a standard reference method of plasma glucose measurement during insulin-induced hypoglycemia...
  43. ncbi request reprint Adrenaline vs glucagon in the primacy of glucose counterregulation
    P De Feo
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Nutr Metab 15:323-7; discussion 328. 2002
  44. ncbi request reprint Effects of whole-body vibration exercise on the endocrine system of healthy men
    C Di Loreto
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences IMISEM, University of Perugia, Perugia, Italy
    J Endocrinol Invest 27:323-7. 2004
    ..Since hormonal responses, with the exception of norepinephrine, are not affected by acute vibration exposure, this type of exercise is not expected to reduce fat mass in obese subjects...
  45. doi request reprint The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women
    Elza Muscelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 22:364-70. 2009
    ....
  46. ncbi request reprint Fluctuation of serum basal insulin levels following single and multiple dosing of insulin glargine
    John Gerich
    University of Rochester Medical Center, Rochester, New York, USA
    Diabetes Technol Ther 8:237-43. 2006
    ..The large fluctuations in blood concentrations and activity observed with insulin therapies such as NPH insulin or insulin ultralente may result in hyper- or hypoglycemia...
  47. ncbi request reprint Glucose variability and complications
    Geremia B Bolli
    Diabetes Care 29:1707-9. 2006
  48. ncbi request reprint Insulin- and exercise-stimulated skeletal muscle blood flow and glucose uptake in obese men
    Kirsti Hallsten
    Turku PET Centre and Department of Medicine, University of Helsinki, Finland Department of Medicine, University of Turku, Finland
    Obes Res 11:257-65. 2003
    ..g., skeletal muscle. In the present study, we determined whether insulin resistance in obesity is associated with an impaired ability of exercise to stimulate muscle blood flow, oxygen delivery, or glucose uptake...
  49. ncbi request reprint Establishing the deficiency of glucagon response to hypoglycemia in humans
    Geremia B Bolli
    Endocr Pract 9:164-5. 2003