F Blasi

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint Newer antibiotics for the treatment of respiratory tract infections
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore di Milano, Milan, Italy
    Curr Opin Pulm Med 10:189-96. 2004
  2. ncbi request reprint A review of guidelines for antibacterial use in acute exacerbations of chronic bronchitis
    Francesco Blasi
    Pad LITTA, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122, University of Milan, Policlinico, Milan, Italy
    Pulm Pharmacol Ther 19:361-9. 2006
  3. ncbi request reprint Acute myocardial infarction in hospitalized patients with community-acquired pneumonia
    Julio Ramirez
    Divisions of Infectious Diseases, University of Louisville and Veterans Administration, Louisville, Kentucky 40202, USA
    Clin Infect Dis 47:182-7. 2008
  4. pmc Cefditoren versus levofloxacin in patients with exacerbations of chronic bronchitis: serum inflammatory biomarkers, clinical efficacy, and microbiological eradication
    Francesco Blasi
    Department of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, Italy
    Ther Clin Risk Manag 9:55-64. 2013
  5. pmc Phenotyping community-acquired pneumonia according to the presence of acute respiratory failure and severe sepsis
    Stefano Aliberti
    Department of Pathophysiology and Transplantation, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, University of Milan, Via F, Sforza 35, Milan, Italy
    Respir Res 15:27. 2014
  6. pmc Early versus later response to treatment in patients with community-acquired pneumonia: analysis of the REACH study
    Francesco Blasi
    Department of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Ospedale Maggiore, Policlinico Cà Granda Milano, Italy
    Respir Res 15:6. 2014
  7. pmc How air pollution influences clinical management of respiratory diseases. A case-crossover study in Milan
    Pierachille Santus
    Dipartimento di Scienze della Salute, Universita degli Studi di Milano, Respiratory Unit, San Paolo Hospital, Milan, Italy
    Respir Res 13:95. 2012
  8. ncbi request reprint Prulifloxacin versus levofloxacin in the treatment of severe COPD patients with acute exacerbations of chronic bronchitis
    F Blasi
    Dipartimento di Fisiopatologia e dei Trapianti, Universita degli Studi di Milano, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda Milano, Via Francesco Sforza 35, 20122 Milan, Italy
    Pulm Pharmacol Ther 26:609-16. 2013
  9. doi request reprint Understanding the burden of pneumococcal disease in adults
    F Blasi
    Respiratory Medicine Section, Dipartimento Toraco Polmonare e Cardiocircolatorio, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda Milan, Milan, Italy
    Clin Microbiol Infect 18:7-14. 2012
  10. doi request reprint Compliance with anti-H1N1 vaccine among healthcare workers and general population
    F Blasi
    Respiratory Medicine Section, Dipartimento Toraco Polmonare e Cardiocircolatorio, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda, Milan, Italy
    Clin Microbiol Infect 18:37-41. 2012

Collaborators

Detail Information

Publications98

  1. ncbi request reprint Newer antibiotics for the treatment of respiratory tract infections
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore di Milano, Milan, Italy
    Curr Opin Pulm Med 10:189-96. 2004
    ..In this review, we highlight some of the developments achieved over the past 2 years in the field of novel antimicrobial compounds...
  2. ncbi request reprint A review of guidelines for antibacterial use in acute exacerbations of chronic bronchitis
    Francesco Blasi
    Pad LITTA, IRCCS Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122, University of Milan, Policlinico, Milan, Italy
    Pulm Pharmacol Ther 19:361-9. 2006
    ....
  3. ncbi request reprint Acute myocardial infarction in hospitalized patients with community-acquired pneumonia
    Julio Ramirez
    Divisions of Infectious Diseases, University of Louisville and Veterans Administration, Louisville, Kentucky 40202, USA
    Clin Infect Dis 47:182-7. 2008
    ..The objective of this study was to investigate the association of AMI with the severity of pneumonia at hospitalization and clinical failure during hospitalization among patients with CAP...
  4. pmc Cefditoren versus levofloxacin in patients with exacerbations of chronic bronchitis: serum inflammatory biomarkers, clinical efficacy, and microbiological eradication
    Francesco Blasi
    Department of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, Italy
    Ther Clin Risk Manag 9:55-64. 2013
    ....
  5. pmc Phenotyping community-acquired pneumonia according to the presence of acute respiratory failure and severe sepsis
    Stefano Aliberti
    Department of Pathophysiology and Transplantation, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, University of Milan, Via F, Sforza 35, Milan, Italy
    Respir Res 15:27. 2014
    ..The aim of the study was to evaluate prevalence, characteristics, risk factors and impact on mortality of hospitalized patients with CAP according to the presence of ARF and SS on admission...
  6. pmc Early versus later response to treatment in patients with community-acquired pneumonia: analysis of the REACH study
    Francesco Blasi
    Department of Pathophysiology and Transplantation, University of Milan, IRCCS Fondazione Ospedale Maggiore, Policlinico Cà Granda Milano, Italy
    Respir Res 15:6. 2014
    ....
  7. pmc How air pollution influences clinical management of respiratory diseases. A case-crossover study in Milan
    Pierachille Santus
    Dipartimento di Scienze della Salute, Universita degli Studi di Milano, Respiratory Unit, San Paolo Hospital, Milan, Italy
    Respir Res 13:95. 2012
    ..We investigated the correlation between emergency room admissions (ERAs) of the general population for respiratory diseases and the environmental pollutant levels in Milan, a metropolis in northern Italy...
  8. ncbi request reprint Prulifloxacin versus levofloxacin in the treatment of severe COPD patients with acute exacerbations of chronic bronchitis
    F Blasi
    Dipartimento di Fisiopatologia e dei Trapianti, Universita degli Studi di Milano, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda Milano, Via Francesco Sforza 35, 20122 Milan, Italy
    Pulm Pharmacol Ther 26:609-16. 2013
    ..Antimicrobial therapy of chronic bronchitis exacerbations in patients with severe chronic obstructive pulmonary disease (COPD) is based on empiric antibiotic treatment...
  9. doi request reprint Understanding the burden of pneumococcal disease in adults
    F Blasi
    Respiratory Medicine Section, Dipartimento Toraco Polmonare e Cardiocircolatorio, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda Milan, Milan, Italy
    Clin Microbiol Infect 18:7-14. 2012
    ..Vaccination against S. pneumoniae with new conjugate vaccines seems to be the most promising field for real improvement in the management of pneumococcal infections in adults...
  10. doi request reprint Compliance with anti-H1N1 vaccine among healthcare workers and general population
    F Blasi
    Respiratory Medicine Section, Dipartimento Toraco Polmonare e Cardiocircolatorio, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico Cà Granda, Milan, Italy
    Clin Microbiol Infect 18:37-41. 2012
    ..Better communication strategies to improve vaccination acceptance by the general population and by healthcare workers are required...
  11. doi request reprint The role of biomarkers in low respiratory tract infections
    Francesco Blasi
    Dipartimento Toraco polmonare e Cardio circolatorio, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Via F Sforza 35, Milan, Italy
    Eur J Intern Med 23:429-35. 2012
    ....
  12. doi request reprint Antibiotics as immunomodulant agents in COPD
    Francesco Blasi
    Respiratory Medicine Section, Dipartimento Toraco Polmonare e Cardiocircolatorio, University of Milan, IRCCS Fondazione Cà Granda Ospedale Maggiore, Milan, Italy
    Curr Opin Pharmacol 12:293-9. 2012
    ..New macrolide derivatives devoid of antibacterial activity have been synthetized. This review analyses the relevance of immunomodulatory and anti-inflammatory effects of antibiotics in the management of COPD...
  13. pmc Severe asthma exacerbation: role of acute Chlamydophila pneumoniae and Mycoplasma pneumoniae infection
    Roberto Cosentini
    Emergency Medicine Department, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Gruppo NIV Policlinico, Milan, Italy
    Respir Res 9:48. 2008
    ..Chlamydophila pneumoniae and Mycoplasma pneumoniae are associated with acute exacerbation of bronchial asthma (AEBA). The aim of this study was to evaluate the correlation between these acute bacterial infections and the severity of AEBA...
  14. doi request reprint Antibacterial activity of telithromycin and comparators against pathogens isolated from patients with community-acquired respiratory tract infections: the Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin study year 5
    Francesco Blasi
    University of Milan, Pad SACCO, IRCCS Ospedale Maggiore Policlinico, Italy
    Diagn Microbiol Infect Dis 63:302-8. 2009
    ..influenzae (>99% of isolates susceptible) isolated from patients with CAP, AECB, or bacterial sinusitis. Amoxicillin-clavulanate, levofloxacin, and telithromycin were the most active agents against multidrug-resistant S. pneumoniae...
  15. doi request reprint Can CAP guideline adherence improve patient outcome in internal medicine departments?
    F Blasi
    Institute of Respiratory Diseases, University of Milan, Maggiore Hospital, Fondazione IRCCS Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Eur Respir J 32:902-10. 2008
    ..1 and 5.7%, respectively). Overall, a low compliance with guidelines in the prospective phase (44%) was obtained, indicating the need for future more aggressive and proactive approaches...
  16. pmc Clinical applications of azithromycin microspheres in respiratory tract infections
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Fondazione Policlinico Mangiagalli Regina Elena Milano, Italy
    Int J Nanomedicine 2:551-9. 2007
    ..A further advantage of single-dose therapy is the potential for use as directly-observed therapy, which may be useful in specific clinical conditions...
  17. ncbi request reprint Role of levofloxacin in the treatment of lower respiratory tract infections (LRTIs)
    F Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore di Milano, Italy
    J Chemother 16:11-4. 2004
  18. ncbi request reprint Atypical pathogens and respiratory tract infections
    F Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore, Milan, Italy
    Eur Respir J 24:171-81. 2004
    ....
  19. ncbi request reprint Potential role of antibiotics in the treatment of asthma
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore Milano, Italy
    Curr Drug Targets Inflamm Allergy 3:237-42. 2004
    ..Future lines of research in this field should attempt to determine whether specific antibiotic treatment may alter the natural history of asthma...
  20. pmc Prulifloxacin: a brief review of its potential in the treatment of acute exacerbation of chronic bronchitis
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, Fondazione IRCCS Policlinico Mangiagalli Regina Elena, Milano, Italy
    Int J Chron Obstruct Pulmon Dis 2:27-31. 2007
    ..This review discusses the most recent data on the new fluoroquinolone prulifloxacin and critically analyses its activity and safety in the management of AECB...
  21. ncbi request reprint Strategic targets of essential host-pathogen interactions
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore Milano, Milano, Italy
    Respiration 72:9-25. 2005
    ....
  22. pmc Chlamydophila pneumoniae induces a sustained airway hyperresponsiveness and inflammation in mice
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore Fondazione Policlinico Mangiagalli Regina Elena, Milano, Italy
    Respir Res 8:83. 2007
    ..pneumoniae is involved in the initiation and promotion of asthma and chronic obstructive pulmonary diseases (COPD). Surprisingly, the effect of C. pneumoniae on airway function has never been investigated...
  23. ncbi request reprint Azithromycin and lower respiratory tract infections
    F Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Fondazione Policlinico Mangiagalli Regina Elena, Milan, Italy
    Expert Opin Pharmacother 6:2335-51. 2005
    ..In addition, pharmacokinetic and pharmacodynamic properties of the drug are also considered...
  24. ncbi request reprint 100 years of respiratory medicine: pneumonia
    Francesco Blasi
    Istituto di Tisiologia e Malattie dell Apparato Respiratorio, University of Milan, Ospedale Maggiore Fondazione IRCCS Policlinico, Mangiagalli e Regina Elena, Via F Sforza 35, Milan 20122, Italy
    Respir Med 101:875-81. 2007
    ..Guidelines have been issued by international and national scientific societies in order to spread the scientific knowledge on this important disease and to improve its management...
  25. ncbi request reprint Highlights on the appropriate use of fluoroquinolones in respiratory tract infections
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, Fondazione IRCCS Policlinico Mangiagalli Regina Elena, Via F Sforza 35, 20122 Milan, Italy
    Pulm Pharmacol Ther 19:11-9. 2006
    ..This review discusses the most recent data on the bacteriological and clinical activity of the new fluoroquinolones and critically analyses the risks of a potential overuse of this valuable new class of drugs...
  26. ncbi request reprint Value of short-course antimicrobial therapy in community-acquired pneumonia
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Fondazione Policlinico Mangiagalli Regina Elena Milano, Italy
    Int J Antimicrob Agents 26:S148-55. 2005
    ..The results of two phase III CAP trials indicate that a single 2.0 g dose of azithromycin microspheres is a suitable alternative to 7 days of either clarithromycin XL or levofloxacin...
  27. doi request reprint Chlamydophila pneumoniae
    F Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Fondazione Ospedale Maggiore, Milan, Italy
    Clin Microbiol Infect 15:29-35. 2009
    ..pneumoniae infection. New macrolides, ketolides and fluoroquinolones are other potentially effective drugs. This review analyses the most recent data concerning the involvement of C. pneumoniae in human diseases...
  28. ncbi request reprint Therapeutic potential of the new quinolones in the treatment of lower respiratory tract infections
    Francesco Blasi
    Institute of Respiratory, University of Milan, IRCCS Ospedale Maggiore Milan, Italy
    Expert Opin Investig Drugs 12:1165-77. 2003
    ..This review discusses the more recent data on bacteriological and clinical activity and critically analyses the risks of a potential overuse of this valuable new class of drugs...
  29. doi request reprint Steps forward in LRTI and tuberculosis: update from the ERS Respiratory Infections Assembly
    F Blasi
    Institute of Respiratory Diseases, University of Milan, Ospedale Maggiore Fondazione IRCCS Policlinico, Milan, Italy
    Eur Respir J 33:1448-53. 2009
    ..and the new epidemiological threat of multidrug-resistant and extensively drug-resistant tuberculosis cases is analysed...
  30. ncbi request reprint Chlamydia pneumoniae DNA detection in peripheral blood mononuclear cells is predictive of vascular infection
    F Blasi
    Istituto di Tisiologia e Malattie dell Apparato Respiratorio, Universita degli Studi di Milano, Pad LITTA, IRCCS Ospedale Maggiore di Milano via F Sforza, 35 I 20122 Milano, Italy
    J Infect Dis 180:2074-6. 1999
    ..pneumoniae DNA is common both in PBMC and in abdominal aortic tissue from patients undergoing abdominal aneurysm surgery. Blood PCR may be a useful tool for identifying subjects carrying C. pneumoniae in the vascular wall...
  31. ncbi request reprint Chlamydia pneumoniae detection in atherosclerotic plaques in Italy
    F Blasi
    Istituto di Tisiologia e Malattie dell Apparato Respiratorio, Universita degli Studi di Milano, Pad LITTA, IRCCS Ospedale Maggiore di Milano, I 20122 Milan, Italy
    J Infect Dis 181:S444-6. 2000
    ..pneumoniae in the vascular wall. Macrolide treatment reduced fibrinogen and C-reactive protein plasma levels and C. pneumoniae burden in patients with atherosclerotic diseases...
  32. doi request reprint Healthcare workers and influenza vaccination: an ERS-ESCMID Web-based survey
    F Blasi
    Respiratory Medicine Section, Dipartimento Toraco Polmonare e Cardiocircolatorio, Universita degli Studi di Milano, IRCCS Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy
    Clin Microbiol Infect 17:1223-5. 2011
    ..The results of this survey should help health authorities to better design future steps for the successful vaccination of healthcare workers...
  33. doi request reprint Biomarkers in lower respiratory tract infections
    Francesco Blasi
    Dipartimento Toraco Polmonare e Cardiocircolatorio, Universita degli Studi di Milano, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Via F Sforza, 35, 20122 Milan, Italy
    Pulm Pharmacol Ther 23:501-7. 2010
    ..Even if more data are required to fully appreciate the role of biomarkers in LRTIs management, there is emerging evidence that biomarkers have the potential to improve the daily clinical management of LRTIs...
  34. ncbi request reprint Chlamydia pneumoniae and Mycoplasma pneumoniae
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Fondazione Ospedale Maggiore Milano, Milan, Italy
    Semin Respir Crit Care Med 26:617-24. 2005
    ..pneumoniae infection. New macrolides, ketolides, and new fluoroquinolones are other potentially effective drugs...
  35. ncbi request reprint Atypical pathogens and asthma: can they influence the natural history of the disease?
    F Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore Milano, Italy
    Monaldi Arch Chest Dis 56:276-80. 2001
    ..Further research is required to determine whether specific antibiotic treatment may alter the natural history of asthma...
  36. ncbi request reprint Therapies in development for community-acquired pneumonia
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS, Ospedale Maggiore, Italy
    Expert Opin Investig Drugs 11:545-52. 2002
    ....
  37. ncbi request reprint Telithromycin in lower respiratory tract infections
    F Blasi
    University of Milan, Institute of Respiratory Diseases, IRCCS Ospedale Maggiore Milano, Milan, Italy
    Future Microbiol 1:7-16. 2006
    ..In addition, pharmacokinetic and pharmacodynamic properties of the drug are considered...
  38. pmc Chlamydia pneumoniae and chronic bronchitis: association with severity and bacterial clearance following treatment
    F Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore di Milano, Milan, Italy
    Thorax 57:672-6. 2002
    ....
  39. ncbi request reprint Long-term azithromycin use in patients with chronic obstructive pulmonary disease and tracheostomy
    Francesco Blasi
    Dipartimento Toraco polmonare e Cardio circolatorio, University of Milan, IRCCS Fondazione Po Ma Re, Milan, Italy
    Pulm Pharmacol Ther 23:200-7. 2010
    ..Long-term azithromycin treatment seems to be safe and effective in severe COPD outpatients with tracheostomy in reducing exacerbations, hospitalizations, as well as in improving quality of life...
  40. ncbi request reprint Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with pneumonia. Mowgli Study Group
    S Esposito
    Paediatric Dept I, Istituto di Ricerca e di Cura a Carattere Scientifico, Maggiore Hospital, Milan, Italy
    Eur Respir J 17:241-5. 2001
    ..The priorities for future research include the development of rapid, easily accessible and cost-effective diagnostic tests useful for each episode of pneumonia in children...
  41. ncbi request reprint Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community-acquired lower respiratory tract infections
    N Principi
    Pediatric Department I, University of Milan, Milan, Italy
    Clin Infect Dis 32:1281-9. 2001
    ..pneumoniae and/or C. pneumoniae plays a significant role in community-acquired LRTIs in children of all ages and that such infections have a more complicated course when not treated with adequate antimicrobial agents...
  42. doi request reprint Duration of antibiotic therapy in hospitalised patients with community-acquired pneumonia
    S Aliberti
    Dipartimento Toraco polmonare e Cardio circolatorio, University of Milan, Milan, Italy
    Eur Respir J 36:128-34. 2010
    ..Duration of therapy is not influenced by either the severity of disease at the time of hospitalisation or the clinical response to therapy...
  43. ncbi request reprint Treatment of Helicobacter pylori and Chlamydia pneumoniae infections decreases fibrinogen plasma level in patients with ischemic heart disease
    G Torgano
    Emergency Department, Ospedale Maggiore, IRCCS, Milan, Italy
    Circulation 99:1555-9. 1999
    ..The aim of our study was to evaluate changes in fibrinogen level in patients with IHD and H pylori and/or C pneumoniae positivity randomly assigned to antibiotic treatment...
  44. ncbi request reprint Use of antimicrobial agents for community-acquired lower respiratory tract infections in hospitalised children
    S Esposito
    Pediatric Department 1, University of Milan, Italy
    Eur J Clin Microbiol Infect Dis 20:647-50. 2001
    ..In order to contain costs and limit the risk of resistant bacteria emerging, it is urgent that pediatricians and parents be educated in the proper use of antibiotics...
  45. ncbi request reprint Antibiotic treatment and baseline severity of disease in acute exacerbations of chronic bronchitis: a re-evaluation of previously published data of a placebo-controlled randomized study
    L Allegra
    Institute of Respiratory Diseases, Department of Emergency Medicine, Milan, Italy
    Pulm Pharmacol Ther 14:149-55. 2001
    ..Our patients with severe functional impairment and higher number of exacerbations per year are those who derive the greatest benefit from antibiotic treatment. Copyright Academic Press...
  46. ncbi request reprint Guidelines for the management of adult lower respiratory tract infections
    M Woodhead
    Dept of Respiratory Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK, and Istituto di Tisiologia e Malattie dell Apparato Respiratorio, Universita degli Studi di Milano, Italy
    Eur Respir J 26:1138-80. 2005
  47. ncbi request reprint Community-acquired pneumonia: role of atypical organisms
    R Cosentini
    Department of Emergency Medicine, IRCCS Ospedale Maggiore di Milano, Divisione Medicina d Urgenza, Via F Sforza, 35, 20122 Milan, Italy
    Monaldi Arch Chest Dis 56:527-34. 2001
    ..pneumoniae infection. New macrolides, ketolides, and new fluoroquinolones are other potentially effective drugs...
  48. ncbi request reprint The pneumonia severity index and the CRB-65 in cancer patients with community-acquired pneumonia
    S Aliberti
    Dipartimento Toraco polmonare e Cardio circolatorio, University of Milan, Milan, Italy
    Int J Tuberc Lung Dis 13:1550-6. 2009
    ..The ability of the pneumonia severity index (PSI) and the CRB-65 to identify patients with low vs. high risk for mortality among cancer patients with CAP has not been evaluated...
  49. ncbi request reprint Role of atypical bacteria and azithromycin therapy for children with recurrent respiratory tract infections
    Susanna Esposito
    Institute of Pediatrics, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy
    Pediatr Infect Dis J 24:438-44. 2005
    ....
  50. doi request reprint Role of atypical bacteria in children undergoing tonsillectomy because of severely recurrent acute tonsillopharyngitis
    S Esposito
    Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Institute of Pediatrics, University of Milan, Via Commenda 9, 20122, Milano, Italy
    Eur J Clin Microbiol Infect Dis 27:1233-7. 2008
    ..pneumoniae, and that tonsillectomy seems to be effective in reducing the recurrence of both AT and acute respiratory disease during 12 months follow-up postsurgery...
  51. doi request reprint The role of neutropenia on outcomes of cancer patients with community-acquired pneumonia
    S Aliberti
    Institute of Respiratory Disease, University of Milan, Ospedale Maggiore Fondazione IRCCS Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Eur Respir J 33:142-7. 2009
    ..30). Lack of neutropenia, during the initial evaluation of a cancer community-acquired pneumonia patient, should not be considered an indicator of better clinical outcome...
  52. ncbi request reprint Serum level of soluble urokinase-type plasminogen activator receptor is a strong and independent predictor of survival in human immunodeficiency virus infection
    N Sidenius
    Department of Molecular Pathology and Medicine, Molecular Genetics Unit, DIBIT, San Raffaele Scientific Institute, Milan, Italy
    Blood 96:4091-5. 2000
    ..This report is the first to demonstrate an important association between the plasminogen activator system and disease progression in HIV-1 infection...
  53. ncbi request reprint Acute tonsillopharyngitis associated with atypical bacterial infection in children: natural history and impact of macrolide therapy
    Susanna Esposito
    Institute of Pediatrics, University of Milan, Milano, Italy
    Clin Infect Dis 43:206-9. 2006
    ..pneumoniae and C. pneumoniae may have a negative outcome with a high risk of recurrence of respiratory illness...
  54. ncbi request reprint A 13-year-old female with shortness of breath and pleuritic chest pain
    S Aliberti
    Institute of Respiratory Diseases, University of Milan, IRCCS Fondazione Policlinico Mangiagalli Regina Elena Milano, Milan, Italy
    Eur Respir J 28:876-82. 2006
  55. ncbi request reprint Non-invasive continuous positive airway pressure in monolateral lung transplant patient with pneumonia and IPF
    S Aliberti
    Dipartimento Toraco polmonare e Cardio circolatorio, University of Milan, IRCCS Fondazione Po Ma Re, Milan, Italy
    Monaldi Arch Chest Dis 73:169-75. 2010
    ..We studied the effects of the application of positive end-expiratory pressure on both the right native lung affected by IPF and the transplanted lung affected by pneumonia...
  56. ncbi request reprint Stromelysin-1 polymorphism as a new potential risk factor in progression of chronic obstructive pulmonary disease
    P Santus
    Institute of Lung Disease, University of Milan, Respiratory Unit, San Paolo Hospital, Milano, Italy
    Monaldi Arch Chest Dis 71:15-20. 2009
    ..Altered MMP-3 activity has been described in different diseases. We investigated the role of a promoter MMP-3 polymorphism in determining susceptibility and severity of COPD...
  57. ncbi request reprint Possible stage-specific function of NF-kappaB during pre-B cell differentiation
    L Guerrini
    Department of Genetics and Microbial Biology, University of Milan, Italy
    FEBS Lett 434:140-4. 1998
    ..The data indicate that NF-kappaB, while important to initiate the process of Ig kappa gene transcription in 70Z/3 pre-B cells, is no longer required for its maintenance in differentiated 70Z/3 cells...
  58. ncbi request reprint Aetiology of acute pharyngitis: the role of atypical bacteria
    Susanna Esposito
    Institute of Paediatrics, IRCCS Maggiore Hospital, University of Milan, Milan, Italy
    J Med Microbiol 53:645-51. 2004
    ..pneumoniae seems to be mainly a co-pathogen. To avoid the risk of an incorrect therapeutic approach, simple laboratory investigations that allow rapid identification of M. pneumoniae infections are urgently needed...
  59. doi request reprint Consensus document on controversial issues for the treatment of hospital-associated pneumonia
    Fabio Franzetti
    Clinica Universitaria di Malattie Infettive e Tropicali, Azienda Ospedaliera Universitaria Luigi Sacco, Universita degli Studi di Milano, Milano, Italy
    Int J Infect Dis 14:S55-65. 2010
    ..Many aspects of the treatment of HAP caused by multi-resistant Gram-positive microorganisms have been extensively studied, but controversial issues remain...
  60. pmc Detection of respiratory viruses and atypical bacteria in children's tonsils and adenoids
    Lorenzo Drago
    Laboratory of Microbiology, Department of Preclinical Sciences, LITA Vialba, Via GB Grassi 74, University of Milan, Milan 20157, Italy
    J Clin Microbiol 46:369-70. 2008
    ..Viruses were detected in 47.7% of the children and 37.3% of the specimens, with adenovirus and parainfluenza viruses being the most frequently detected microorganisms...
  61. pmc Increased Mycobacterium tuberculosis growth in HIV-1-infected human macrophages: role of tumour necrosis factor-alpha
    F G Imperiali
    Division of Hematology, University of Milan, IRCCS Ospedale Maggiore, Milan, Italy
    Clin Exp Immunol 123:435-42. 2001
    ..Here, for the first time we demonstrated an enhanced M. tuberculosis growth in HIV-1-infected MDM, in line with the observed clinical synergism between the two infections...
  62. ncbi request reprint Shedding and cleavage of the urokinase receptor (uPAR): identification and characterisation of uPAR fragments in vitro and in vivo
    N Sidenius
    Department of Molecular Pathology and Medicine, Molecular Genetics Unit, DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    FEBS Lett 475:52-6. 2000
    ..Our study demonstrates that potentially biologically active uPAR fragments are produced in the human body, indicating a possible function in the regulation of not only proteolysis but also signal transduction related processes...
  63. ncbi request reprint Domain 1 of the urokinase receptor (uPAR) is required for uPAR-mediated cell binding to vitronectin
    N Sidenius
    Department of Molecular Pathology and Medicine, Molecular Genetics Unit, DIBIT, San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    FEBS Lett 470:40-6. 2000
    ..The failure of the mutant uPAR to promote cellular binding is paralleled by a strong reduction in the affinity for vitronectin in vitro...
  64. ncbi request reprint Sputum color as a marker of acute bacterial exacerbations of chronic obstructive pulmonary disease
    Luigi Allegra
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore Milano, Via F Sforza 35, 20122 Milan, Italy
    Respir Med 99:742-7. 2005
    ..Deepening sputum color (from yellowish to brownish) was associated with increased yield of Gram negative and P. aeruginosa/Enterobacteriaceae...
  65. ncbi request reprint The role of antibiotics in asthma
    Francesco Blasi
    Institute of Respiratory Diseases, University of Milan, IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Int J Antimicrob Agents 29:485-93. 2007
    ..The ketolide antibiotics may also have similar properties. This paper discusses the role of these antibiotics in the management of asthma...
  66. ncbi request reprint The role of cefditoren in the treatment of lower community-acquired respiratory tract infections (LRTIs): from bacterial eradication to reduced lung inflammation and epithelial damage
    F di Marco
    Department of Health Sciences, Respiratory Unit, San Paolo Hospital, University of Milan, Italy
    Eur Rev Med Pharmacol Sci 18:321-32. 2014
    ....
  67. pmc Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect
    M Resnati
    Department of Biology and Biotechnology, San Raffaele Scientific Institute, Milano, Italy
    EMBO J 15:1572-82. 1996
    ....
  68. ncbi request reprint cRel-TD kinase: a serine/threonine kinase binding in vivo and in vitro c-Rel and phosphorylating its transactivation domain
    C Fognani
    Department of Molecular Pathology and Medicine, Universita Vita Salute San Raffaele, Milan, Italy
    Oncogene 19:2224-32. 2000
    ....
  69. ncbi request reprint Thymomodulin stimulates phagocytosis in vitro by rat macrophages and human polymorphonuclear cells
    P C Braga
    Department of Pharmacology, School of Medicine, University of Milan, Italy
    J Chemother 5:313-6. 1993
    ....
  70. ncbi request reprint Characteristics of Streptococcus pneumoniae and atypical bacterial infections in children 2-5 years of age with community-acquired pneumonia
    Susanna Esposito
    Pediatric Department I, Istituto Ricerca e Cura a Carattere Scientifico Maggiore Hospital, University of Milan, 20122 Milan, Italy
    Clin Infect Dis 35:1345-52. 2002
    ....
  71. doi request reprint Bronchiectasis: an update
    Maria Pappalettera
    Dipartimento Toraco Polmonare e Cardiovascolare, University of Milan, Istituti di Ricovero e Cura a Carattere Scientifico Fondazione PoMaRe, Milan, Italy
    Clin Respir J 3:126-34. 2009
    ..Bronchiectasis is defined as an abnormal and irreversible dilatation of the bronchi, often associated with chronic productive cough, airway obstruction, and recurrent infections...
  72. ncbi request reprint Anxiety and depression in COPD patients: The roles of gender and disease severity
    Fabiano Di Marco
    Respiratory Medicine Unit, University of Milan, Ospedale San Paolo, Milano, Italy
    Respir Med 100:1767-74. 2006
    ....
  73. ncbi request reprint Chlamydia pneumoniae and acute aortic syndrome: a call for a multi-institutional study
    Eduardo Bossone
    Institute of Respiratory Disease, University of Milan, IRCCS Fondazione Policlinico Mangiagalli Regina Elena, Milano, Italy
    Monaldi Arch Chest Dis 70:68-70. 2008
    ..pneumoniae and acute aortic dissection. Well-designed large prospective studies are needed in order to clarify the pathophysiologic role of CP infection in acute and chronic aortic disease...
  74. doi request reprint Incidence, etiology, timing, and risk factors for clinical failure in hospitalized patients with community-acquired pneumonia
    Stefano Aliberti
    Institute of Respiratory Diseases, University of Milan, Milan, Italy
    Chest 134:955-62. 2008
    ..The objective of this study was to define the incidence, etiology, timing, and risk factors associated with clinical failures related to CAP vs those unrelated to CAP...
  75. pmc The novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativity
    J Berthelsen
    Dipartimento di Genetica e Biologia dei Microrganismi dell Università, H S Raffaele, Via Olgettina 58, 20132, Milan, Italy
    EMBO J 17:1434-45. 1998
    ..Our data suggest that Prep1 is an additional component in the transcriptional regulation by Hox proteins...
  76. ncbi request reprint Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes
    T Teesalu
    Dipartimento di Ricerca Biologica e Tecnologica DIBIT, Istituto Scientifico S Raffaele, Milano, Italy
    Mech Dev 56:103-16. 1996
    ..5 and 8.5 days. Our studies outline the expression of a set of functionally related genes that is well coordinated between fetal and maternal tissues. This coordination may model other physiological and pathological invasive processes...
  77. ncbi request reprint The PBX-regulating protein PREP1 is present in different PBX-complexed forms in mouse
    E Ferretti
    Molecular Genetics Unit, Department of Biology and Biotechnology DIBIT, H S San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    Mech Dev 83:53-64. 1999
    ....
  78. pmc Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro
    L Guerrini
    Department of Genetics and Microbial Biology, University of Milan, Italy
    Proc Natl Acad Sci U S A 92:9077-81. 1995
    ..Overall, these observations suggest the existence of a new pathway of trans-synaptic regulation of gene expression...
  79. ncbi request reprint Purification of the Prep1 interactome identifies novel pathways regulated by Prep1
    Victor M Diaz
    Molecular Genetics Unit, Department of Molecular Biology and Functional Genomics, Università Vita Salute San Raffaele and DIBIT, H San Raffaele, Milan, Italy
    Proteomics 7:2617-23. 2007
    ..The Prep1-TAP complex included Pbx1b, Pbx2, and other nonhomeodomain proteins: p160 Myb-binding protein (p160), beta-actin, NMMHCIIA...
  80. pmc Ligand-engaged urokinase-type plasminogen activator receptor and activation of the CD11b/CD18 integrin inhibit late events of HIV expression in monocytic cells
    Massimo Alfano
    AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy
    Blood 113:1699-709. 2009
    ..Thus, either uPA/uPAR interaction, Mac-1 activation, or prevention of its association with uPAR triggers a signaling pathway leading to the inefficient release of HIV from monocytic cells...
  81. ncbi request reprint Increased keratin content detected by proteomic analysis of exhaled breath condensate from healthy persons who smoke
    Elisabetta Gianazza
    Dipartimento di Scienze Farmacologiche, Gruppo di Studio per la Proteomica e la Struttura delle Proteine, Universita degli Studi di Milano, Milan, Italy
    Am J Med 117:51-4. 2004
  82. ncbi request reprint [Echocardiography and pulmonary arterial hypertension]
    Eduardo Bossone
    Istituto di Malattie dell Apparato Respiratorio, Universita di Milano, IRCCS Ospedale Maggiore, Milano
    Monaldi Arch Chest Dis 68:219-26. 2007
    ....
  83. ncbi request reprint MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription
    Elisa Benasciutti
    Laboratory of Molecular Genetics, S Raffaele Scientific Institute and Università Vita Salute, Milan, Italy
    Blood 104:256-62. 2004
    ..The results suggest that the stress-activated protein kinase (SAPK)/JNK pathway plays an important role in the phosphorylation of Sp1, which, in turn, leads to basal or activated transcription from the uPA-MP element...
  84. ncbi request reprint The effect of telithromycin in acute exacerbations of asthma
    Sebastian L Johnston
    Department of Respiratory Medicine, National Heart and Lung Institute and Wright Fleming Institute of Infection and Immunity, National Heart and Lung Institute, Imperial College London, United Kingdom
    N Engl J Med 354:1589-600. 2006
    ..We conducted a double-blind, randomized, placebo-controlled study to evaluate the efficacy of telithromycin in patients with acute exacerbations of asthma...
  85. ncbi request reprint Pharmacodynamics of levofloxacin in patients with acute exacerbation of chronic bronchitis
    Mario Cazzola
    Department of Pneumology, Unit of Pneumology and Allergology, A Cardarelli Hospital, Naples, Italy
    Chest 128:2093-8. 2005
    ....
  86. ncbi request reprint Delivering antibacterials to the lungs: considerations for optimizing outcomes
    Mario Cazzola
    Department of Respiratory Medicine, Unit of Pneumology and Allergology, A Cardarelli Hospital, Naples, Italy
    Am J Respir Med 1:261-72. 2002
    ....
  87. ncbi request reprint Macrolide and occult infection in asthma
    Mario Cazzola
    A Cardarelli Hospital, Department of Respiratory Medicine, Unit of Pneumology and Allergology, Naples, Italy
    Curr Opin Pulm Med 10:7-14. 2004
    ..These discrepancies highlight the need to define the role, if any, of antimicrobials that are active against atypical pathogens, mainly macrolides, but also tetracyclines and fluoroquinolones, in the treatment of asthma...
  88. ncbi request reprint A worldwide perspective of atypical pathogens in community-acquired pneumonia
    Forest W Arnold
    Division of Infectious Diseases, University of Louisville, Louisville, KY 40292, USA
    Am J Respir Crit Care Med 175:1086-93. 2007
    ..In different regions of the world, monotherapy with a beta-lactam antimicrobial is common...
  89. ncbi request reprint Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study
    Marco Confalonieri
    Azienda Ospedaliero Universitaria di Trieste, Strada di Fiume 447, 34100 Trieste, Italy
    Am J Respir Crit Care Med 171:242-8. 2005
    ..01), MODS score (p = 0.003), and delayed septic shock (p = 0.001). Hydrocortisone treatment was associated with a significant reduction in length of hospital stay (p = 0.03) and mortality (p = 0.009)...
  90. doi request reprint The presence of pneumococcal bacteremia does not influence clinical outcomes in patients with community-acquired pneumonia: results from the Community-Acquired Pneumonia Organization (CAPO) International Cohort study
    Jose Bordon
    Department of Medicine, Section of Infectious Diseases, Providence Hospital, 1150 Varnum St, NE, Washington, DC 20017, USA
    Chest 133:618-24. 2008
    ..The objective of this study was to investigate whether the presence of pneumococcal bacteremia influences the clinical outcomes of hospitalized patients with CAP...
  91. ncbi request reprint Guidelines for empiric antimicrobial prescribing in community-acquired pneumonia
    Thomas M File
    Northeastern Ohio Universities College of Medicine, Rootstown, OH, USA
    Chest 125:1888-901. 2004
    ..Prospective data are required to evaluate which of these two approaches offers clinical superiority...
  92. ncbi request reprint Detection of Chlamydiae pneumoniae but not Helicobacter pylori DNA in atherosclerosis plaques
    Maria P Dore
    Institute of Internal Medicine, University of Sassari, Italy
    Dig Dis Sci 48:945-51. 2003
    ..pylori antigens in the vessel walls. Antigens within vessel atherosclerotic plaques cross-react with H. pylori virulence factors and could act as cofactors in determining instability for the atherosclerotic plaques...
  93. ncbi request reprint Overexpression of PREP-1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation
    Elena Longobardi
    Molecular Genetics Unit, Department of Molecular Biology and Functional Genomics, Università Vita Salute San Raffaele and DIBIT, Via Olgettina 58, 20132 Milan, Italy
    J Biol Chem 278:39235-41. 2003
    ..Thus an increase in PREP-1 leads to changes in the fate-determining HOXb1 and has therefore important functional consequences...
  94. pmc Reliability of nested PCR for detection of Chlamydia pneumoniae DNA in atheromas: results from a multicenter study applying standardized protocols
    Petra Apfalter
    Division of Clinical Microbiology, Hygiene Institute, University of Vienna, Vienna, Austria
    J Clin Microbiol 40:4428-34. 2002
    ..The results of studies by nested PCR for detection of the prevalence of C. pneumoniae will always be questionable...
  95. ncbi request reprint Requirement of the enzymatic and signaling activities of plasmin for phorbol-ester-induced scattering of colon cancer cells
    Victor M Diaz
    Unitat Recerca Biomèdica, Institut de Recerca Hospital Vall d Hebron, Barcelona, Spain
    Exp Cell Res 312:2203-13. 2006
    ..Our observations suggest that plasmin exerts a dual role in PMA-induced scattering of HT29-M6 cells, one directed extracellularly to promote proteolysis of the ECM and one directed to generate intracellular signaling...
  96. ncbi request reprint Binding of Sp1 to the proximal promoter links constitutive expression of the human uPA gene and invasive potential of PC3 cells
    Ines Ibanez-Tallon
    Laboratory of Molecular Genetics, Department of Biological and Technological Research DIBIT and Università Vita Salute, S Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Blood 100:3325-32. 2002
    ..Thus, the cellular context determines the relevance of the GC-/GA-rich region in uPA gene transcription, which contributes to constitutive gene expression, related, in turn, to the invasive phenotype...
  97. ncbi request reprint Lack of PBC-specific antimitochondrial antibodies in patients with Chlamydia pneumoniae infection
    Paolo Busatto
    J Gastroenterol Hepatol 20:1626-7. 2005