Corrado Blandizzi

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi request reprint Inhibition of adenosine deaminase attenuates inflammation in experimental colitis
    Luca Antonioli
    Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Pisa, Italy
    J Pharmacol Exp Ther 322:435-42. 2007
  2. doi request reprint Inducible nitric oxide synthase is involved in endothelial dysfunction of mesenteric small arteries from hypothyroid rats
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Endocrinology 150:1033-42. 2009
  3. ncbi request reprint Enteric alpha-2 adrenoceptors: pathophysiological implications in functional and inflammatory bowel disorders
    Corrado Blandizzi
    Divisione di Farmacologia e Chemioterapia, Dipartimento di Medicina Interna, Universita di Pisa, Via Roma 55, 56126 Pisa, Italy
    Neurochem Int 51:282-8. 2007
  4. ncbi request reprint Clinical efficacy of esomeprazole in the prevention and healing of gastrointestinal toxicity associated with NSAIDs in elderly patients
    Corrado Blandizzi
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Drugs Aging 25:197-208. 2008
  5. doi request reprint The blockade of adenosine deaminase ameliorates chronic experimental colitis through the recruitment of adenosine A2A and A3 receptors
    Luca Antonioli
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma 55, 56126, Pisa, Italy
    J Pharmacol Exp Ther 335:434-42. 2010
  6. doi request reprint Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: role of cyclooxygenase 2-derived contracting prostanoids
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 53:1008-16. 2009
  7. ncbi request reprint CCK2 receptors mediate inhibitory effects of cholecystokinin on the motor activity of guinea-pig distal colon
    Matteo Fornai
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma, 55, 56126 Pisa, Italy
    Eur J Pharmacol 557:212-20. 2007
  8. doi request reprint Nonsteroidal anti-inflammatory drug-activated gene-1 plays a role in the impairing effects of cyclooxygenase inhibitors on gastric ulcer healing
    Rocchina Colucci
    Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Via Roma 55, 56126, Pisa, Italy
    J Pharmacol Exp Ther 342:140-9. 2012
  9. doi request reprint Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: Characterization of molecular mechanisms
    Matteo Fornai
    Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Pharmacol Res 63:59-67. 2011
  10. ncbi request reprint Differential role of cyclooxygenase 1 and 2 isoforms in the modulation of colonic neuromuscular function in experimental inflammation
    Matteo Fornai
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Pharmacol Exp Ther 317:938-45. 2006

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Inhibition of adenosine deaminase attenuates inflammation in experimental colitis
    Luca Antonioli
    Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Pisa, Italy
    J Pharmacol Exp Ther 322:435-42. 2007
    ....
  2. doi request reprint Inducible nitric oxide synthase is involved in endothelial dysfunction of mesenteric small arteries from hypothyroid rats
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Endocrinology 150:1033-42. 2009
    ..It is suggested that in this animal model, characterized by TSH elevation and low-grade inflammation, an increased expression and function of iNOS, resulting in superoxide generation, accounts for an impaired NO availability...
  3. ncbi request reprint Enteric alpha-2 adrenoceptors: pathophysiological implications in functional and inflammatory bowel disorders
    Corrado Blandizzi
    Divisione di Farmacologia e Chemioterapia, Dipartimento di Medicina Interna, Universita di Pisa, Via Roma 55, 56126 Pisa, Italy
    Neurochem Int 51:282-8. 2007
    ..The present review discusses pathophysiological implications of enteric alpha2-adrenoceptors, in the attempt to highlight potential therapeutic applications for drugs targeted on these receptors...
  4. ncbi request reprint Clinical efficacy of esomeprazole in the prevention and healing of gastrointestinal toxicity associated with NSAIDs in elderly patients
    Corrado Blandizzi
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Drugs Aging 25:197-208. 2008
    ..Thus, esomeprazole can be regarded as a useful option for prophylactic therapy in elderly patients receiving long-term NSAID therapy...
  5. doi request reprint The blockade of adenosine deaminase ameliorates chronic experimental colitis through the recruitment of adenosine A2A and A3 receptors
    Luca Antonioli
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma 55, 56126, Pisa, Italy
    J Pharmacol Exp Ther 335:434-42. 2010
    ....
  6. doi request reprint Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: role of cyclooxygenase 2-derived contracting prostanoids
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 53:1008-16. 2009
    ....
  7. ncbi request reprint CCK2 receptors mediate inhibitory effects of cholecystokinin on the motor activity of guinea-pig distal colon
    Matteo Fornai
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma, 55, 56126 Pisa, Italy
    Eur J Pharmacol 557:212-20. 2007
    ....
  8. doi request reprint Nonsteroidal anti-inflammatory drug-activated gene-1 plays a role in the impairing effects of cyclooxygenase inhibitors on gastric ulcer healing
    Rocchina Colucci
    Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Via Roma 55, 56126, Pisa, Italy
    J Pharmacol Exp Ther 342:140-9. 2012
    ....
  9. doi request reprint Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: Characterization of molecular mechanisms
    Matteo Fornai
    Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Pharmacol Res 63:59-67. 2011
    ....
  10. ncbi request reprint Differential role of cyclooxygenase 1 and 2 isoforms in the modulation of colonic neuromuscular function in experimental inflammation
    Matteo Fornai
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Pharmacol Exp Ther 317:938-45. 2006
    ..In the presence of inflammation, COX-1 activity is hampered by oxidative stress, and COX-2 seems to play a predominant role in maintaining an inhibitory control of colonic neuromuscular function...
  11. doi request reprint Emerging role of cyclooxygenase isoforms in the control of gastrointestinal neuromuscular functions
    Matteo Fornai
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Pharmacol Ther 125:62-78. 2010
    ..This review illustrates and discusses current knowledge of the roles played by COX pathways in the regulation of gastrointestinal neuromuscular functions, both under normal conditions and in the presence of gut disorders...
  12. ncbi request reprint Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage
    Corrado Blandizzi
    Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine University of Pisa, Via Roma 55, I 56126 Pisa, Italy
    World J Gastroenterol 11:4052-60. 2005
    ..This study investigated the mechanisms of protection afforded by the proton pump inhibitor lansoprazole against gastric injury induced by different non-steroidal anti-inflammatory drugs (NSAIDs) in rats...
  13. doi request reprint Endothelial dysfunction in small arteries of essential hypertensive patients: role of cyclooxygenase-2 in oxidative stress generation
    Agostino Virdis
    Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Hypertension 62:337-44. 2013
    ..COX-2 represents a major source of oxidative stress generation, whereas nicotinamide adenine dinucleotide phosphate oxidase plays a minor, but significant, role in promoting superoxide generation. ..
  14. ncbi request reprint Resistance artery mechanics and composition in angiotensin II-infused mice: effects of cyclooxygenase-1 inhibition
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Eur Heart J 33:2225-34. 2012
    ....
  15. doi request reprint Effects of pantoprazole on ulcer healing delay associated with NSAID treatment
    Matteo Fornai
    Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Via Roma 55, 56126, Pisa, Italy
    Naunyn Schmiedebergs Arch Pharmacol 379:305-13. 2009
    ..It is concluded that, along with acid suppression, pantoprazole exerts acid-independent effects on ulcer healing, which can be ascribed to a decrease in tissue oxidation and apoptosis...
  16. doi request reprint Immunohistochemical analysis of myenteric ganglia and interstitial cells of Cajal in ulcerative colitis
    Nunzia Bernardini
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    J Cell Mol Med 16:318-27. 2012
    ....
  17. ncbi request reprint NSAID-induced enteropathy: are the currently available selective COX-2 inhibitors all the same?
    Matteo Fornai
    Department of Clinical and Experimental Medicine M F, L A, R C, C P, G G, M T, C B, Department of Pharmacy L T, A Mar, V C, Department of Translational Research and New Technologies in Medicine and Surgery A Mat, G N, University of Pisa, Pisa, Italy Clinical Pharmacology and Digestive Pathophysiology Unit, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy C S
    J Pharmacol Exp Ther 348:86-95. 2014
    ..The selectivity profile of COX-1/COX-2 inhibition by test drugs and the related effects on prostaglandin production do not appear to play a major role in the pathogenesis of enteropathy. ..
  18. doi request reprint Differential recruitment of high affinity A1 and A2A adenosine receptors in the control of colonic neuromuscular function in experimental colitis
    Luca Antonioli
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Eur J Pharmacol 650:639-49. 2011
    ..Under bowel inflammation, A(1) receptor loses its modulating actions, while the recruitment of A(2A) receptor by CD73-dependent endogenous adenosine drives an enhanced inhibitory control of colonic neuromotility...
  19. ncbi request reprint A2a receptors mediate inhibitory effects of adenosine on colonic motility in the presence of experimental colitis
    Luca Antonioli
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Inflamm Bowel Dis 12:117-22. 2006
    ..Adenosine regulates immunity and inflammation, and acts also as a modulator of gut functions. In this study, we investigated the role of adenosine A2a receptors on colonic motility in a rat model of experimental colitis...
  20. doi request reprint Vascular generation of tumor necrosis factor-α reduces nitric oxide availability in small arteries from visceral fat of obese patients
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Am Coll Cardiol 58:238-47. 2011
    ....
  21. doi request reprint Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-inflammatory therapy
    Corrado Blandizzi
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma 55, Pisa 56126, Italy
    Pharmacol Res 59:90-100. 2009
    ....
  22. ncbi request reprint Adenosine deaminase in the modulation of immune system and its potential as a novel target for treatment of inflammatory disorders
    Luca Antonioli
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Curr Drug Targets 13:842-62. 2012
    ..In addition, the interest in designing and developing novel ADA inhibitors, as new tools potentially useful for the therapeutic management of inflammatory disorders, has been discussed...
  23. ncbi request reprint Pharmacological modulation of adenosine system: novel options for treatment of inflammatory bowel diseases
    Luca Antonioli
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Inflamm Bowel Dis 14:566-74. 2008
    ....
  24. doi request reprint Use of selective serotonin reuptake inhibitors during pregnancy and risk of major and cardiovascular malformations: an update
    Marco Tuccori
    Unit of Pharmacology, University Hospital of Pisa, Pisa, Italy
    Postgrad Med 122:49-65. 2010
    ..Accordingly, we are not yet able to rule out the possibility that positive associations, as determined in some studies, result from analyses of poor quality...
  25. pmc Rosuvastatin prevents angiotensin II-induced vascular changes by inhibition of NAD(P)H oxidase and COX-1
    Rocchina Colucci
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Br J Pharmacol 169:554-66. 2013
    ..We investigated the effect of rosuvastatin on endothelial dysfunction, vascular remodelling, changes in extracellular matrix components and mechanical properties of small mesenteric arteries from angiotensin II-infused rats...
  26. doi request reprint Histopathology in gastrointestinal neuromuscular diseases: methodological and ontological issues
    Nunzia Bernardini
    Unit of Histology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    Adv Anat Pathol 20:17-31. 2013
    ..This review article intends to address current methodological and ontological issues in the histopathologic diagnosis of GINMDs, to foster the debate on how to discriminate normal morphology from abnormalities...
  27. ncbi request reprint Cyclooxygenase-1 is involved in endothelial dysfunction of mesenteric small arteries from angiotensin II-infused mice
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 49:679-86. 2007
    ....
  28. doi request reprint Regulation of enteric functions by adenosine: pathophysiological and pharmacological implications
    Luca Antonioli
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Pharmacol Ther 120:233-53. 2008
    ....
  29. pmc Overlap of functional heartburn and gastroesophageal reflux disease with irritable bowel syndrome
    Nicola De Bortoli
    Nicola de Bortoli, Irene Martinucci, Massimo Bellini, Santino Marchi, Division of Gastroenterology, University of Pisa, 56124 Pisa, Italy
    World J Gastroenterol 19:5787-97. 2013
    ....
  30. pmc Altered expression pattern of molecular factors involved in colonic smooth muscle functions: an immunohistochemical study in patients with diverticular disease
    Letizia Mattii
    Unit of Histology and Medical Embriology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    PLoS ONE 8:e57023. 2013
    ..Accordingly, the main purpose of this study was to evaluate the expression patterns of molecular factors involved in the contractile functions of SMCs in the tunica muscularis of colonic specimens from patients with DD...
  31. ncbi request reprint In vivo adenosine A(2B) receptor desensitization in guinea-pig airway smooth muscle: implications for asthma
    Maria Cristina Breschi
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Via Bonanno 6, I 56126, Pisa, Italy
    Eur J Pharmacol 575:149-57. 2007
    ..These findings can be relevant to better understand adenosine functions in airways as well as mechanisms of action of asthma therapies targeting the adenosine system...
  32. ncbi request reprint Cyclooxygenase-2 induction after oral surgery does not entirely account for analgesia after selective blockade of cyclooxygenase 2 in the preoperative period
    Matteo Fornai
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Italy
    Anesthesiology 104:152-7. 2006
    ....
  33. doi request reprint Autoimmune hemolytic anemia following MF59-adjuvanted influenza vaccine administration: a report of two cases
    Sabrina Montagnani
    Tuscan Regional Centre of Pharmacovigilance, Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, School of Medicine and Surgery, Pisa, Italy
    Ann Pharmacother 45:e8. 2011
    ..To describe 2 cases of autoimmune hemolytic anemia (AIHA) following the administration of MF59-adjuvanted influenza vaccine...
  34. doi request reprint Transient acute liver failure complicating transurethral resection syndrome
    Marco Tuccori
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Florence, Florence, Italy
    Scand J Urol Nephrol 44:269-72. 2010
    ..However, further studies are warranted to confirm whether hepatic injury can represent a possible complication of TUR syndrome when ethanol solution is used as irrigant fluid...
  35. ncbi request reprint Mechanisms of gastroprotection by lansoprazole pretreatment against experimentally induced injury in rats: role of mucosal oxidative damage and sulfhydryl compounds
    Gianfranco Natale
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Toxicol Appl Pharmacol 195:62-72. 2004
    ..It is also proposed that lansoprazole does not exert modulator effects on the gastric expression of COX isoforms as well as on the activity of NO pathways...
  36. doi request reprint Safety concerns associated with the use of serotonin reuptake inhibitors and other serotonergic/noradrenergic antidepressants during pregnancy: a review
    Marco Tuccori
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Pisa, Italy
    Clin Ther 31:1426-53. 2009
    ..There is ongoing debate about the safety of selective serotonin reuptake inhibitors (SSRIs) and other serotonergic/noradrenergic antidepressants when used during pregnancy...
  37. pmc Lack of pharmacokinetic bioequivalence between generic and branded amoxicillin formulations. A post-marketing clinical study on healthy volunteers
    Mario Del Tacca
    Clinical Pharmacology Centre for Drug Experimentation, Pisa University Hospital, Pisa, Italy
    Br J Clin Pharmacol 68:34-42. 2009
    ..The aim was to establish whether two generic formulations of amoxicillin, available on the Italian market, fulfil the criteria for clinical pharmacokinetic bioequivalence vs. the branded drug...
  38. ncbi request reprint Cyclooxygenase-2 inhibition improves vascular endothelial dysfunction in a rat model of endotoxic shock: role of inducible nitric-oxide synthase and oxidative stress
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    J Pharmacol Exp Ther 312:945-53. 2005
    ..Oxidative stress is the main mechanism responsible for reduced NO availability, and COX-2 might act as a source of ROS...
  39. pmc Gastrin promotes human colon cancer cell growth via CCK-2 receptor-mediated cyclooxygenase-2 induction and prostaglandin E2 production
    Rocchina Colucci
    Interdepartmental Center for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Br J Pharmacol 144:338-48. 2005
    ....
  40. doi request reprint Statin-associated psychiatric adverse events: a case/non-case evaluation of an Italian database of spontaneous adverse drug reaction reporting
    Marco Tuccori
    Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Pisa, Italy
    Drug Saf 31:1115-23. 2008
    ..Special attention is currently being paid to the potential for statin-induced sleep disorders...
  41. ncbi request reprint Improved tonsillar disposition of azithromycin following a 3-day oral treatment with 20 mg kg(-1) in paediatric patients
    Fabio Baschiera
    Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Italy
    Pharmacol Res 46:95-100. 2002
    ..These findings give pharmacokinetic support to the suggestion that increments of azithromycin dosing might ensure enhanced therapeutic levels at infective sites of the upper respiratory tract...
  42. pmc Influence of the serotonin transporter 5HTTLPR polymorphism on symptom severity in irritable bowel syndrome
    Rocchina Colucci
    Division of Pharmacology and Chemotherapy, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    PLoS ONE 8:e54831. 2013
    ..In addition, the present findings do not support an association of 5HTTLPR with IBS or its clinical presentation in terms of bowel habit predominance...
  43. ncbi request reprint Role of cyclooxygenase isoforms and nitric-oxide synthase in the modulation of tracheal motor responsiveness in normal and antigen-sensitized Guinea pigs
    Paola Nieri
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia, e Biotecnologie, via Bonanno no 6, 56126 Pisa, Italy
    J Pharmacol Exp Ther 319:648-56. 2006
    ....
  44. doi request reprint Quantitative evaluation of myenteric ganglion cells in normal human left colon: implications for histopathological analysis
    Chiara Ippolito
    Section of Histology and Medical Embryology, Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Cell Tissue Res 336:191-201. 2009
    ....
  45. doi request reprint The genetics of the serotonin transporter and irritable bowel syndrome
    Rocchina Colucci
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma 55, I 56126, Pisa, Italy
    Trends Mol Med 14:295-304. 2008
    ..The present review highlights recent advances in SERT genetics, discusses their implications for potential therapeutic applications of SSRIs in IBS and presents original suggestions for future investigations...
  46. doi request reprint The role of purinergic pathways in the pathophysiology of gut diseases: pharmacological modulation and potential therapeutic applications
    Luca Antonioli
    Department of Clinical and Experimental Medicine, University of Pisa, Italy
    Pharmacol Ther 139:157-88. 2013
    ....
  47. pmc Acute portal vein thrombosis precipitated by indomethacin in a HCV-positive elderly patient
    Stefania Mantarro
    Tuscan Regional Centre for Pharmacovigilance, Interdepartmental Centre for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Via Roma 55, Pisa 56126, Italy
    BMC Geriatr 12:69. 2012
    ..We describe a case of acute portal vein thrombosis (PVT) in a hepatitis C virus (HCV)-positive elderly patient following administration of indomethacin...
  48. doi request reprint Hydrogen sulphide: novel opportunity for drug discovery
    Alma Martelli
    Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Pisa, Italy
    Med Res Rev 32:1093-130. 2012
    ....
  49. doi request reprint Esomeprazole-induced hyperchromograninemia in the absence of concomitant hypergastrinemia
    Giovanni Gori
    Division of Pharmacology and Chemotherapy, Department of Internal Medicine, University of Pisa, Via Roma, 55 56126 Pisa, Italy
    Nat Rev Gastroenterol Hepatol 7:642-6. 2010
    ..These findings were interpreted as being suggestive of neuroendocrine tumor relapse...
  50. doi request reprint Immunity, inflammation and cancer: a leading role for adenosine
    Luca Antonioli
    1 Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy 2 Department of Surgery and Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey 07103, USA
    Nat Rev Cancer 13:842-57. 2013
    ..This Review critically discusses the role of adenosine and its receptors in regulating the complex interplay among immune, inflammatory, endothelial and cancer cells during the course of neoplastic disease. ..
  51. doi request reprint Telogen effluvium following bivalent human papillomavirus vaccine administration: a report of two cases
    Marco Tuccori
    Unit of Pharmacology, Tuscan Regional Center of Pharmacovigilance, University Hospital of Pisa, and Department of Internal Medicine, Interdepartmental Center of Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Pisa, Italy
    Dermatology 224:212-4. 2012
    ..Caregivers should ensure psychiatric support to their patients to manage the social and emotional distress that might be associated with hair loss...
  52. pmc A holistic view of adenosine in the control of intestinal neuromuscular functions: the enteric 'purinome' concept
    Luca Antonioli
    Br J Pharmacol 164:1577-9. 2011
    ..This commentary discusses the role of the 'purinome' in the modulation of enteric neuromuscular activity, pointing out its involvement in the intestinal neuroplasticity associated with bowel dysmotility...
  53. pmc Altered prejunctional modulation of intestinal cholinergic and noradrenergic pathways by alpha2-adrenoceptors in the presence of experimental colitis
    Corrado Blandizzi
    Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Via Roma, 55, Pisa 56126, Italy
    Br J Pharmacol 139:309-20. 2003
    ..Evidence was obtained that such modulatory actions depend on an increased expression of alpha(2A)-adrenoceptors within the enteric nervous system...
  54. pmc Inclusion of rituximab in treatment protocols for non-Hodgkin's lymphomas and risk for progressive multifocal leukoencephalopathy
    Marco Tuccori
    Department of Experimental Pathology, University of Pisa, Pisa, Italy
    Oncologist 15:1214-9. 2010
    ..2 every 1,000 patient-years; 95% confidence interval, 0.1-4.3). Interpretation. Based on this finding, clinical surveillance of PML-related symptoms is recommended in NHL patients exposed to rituximab...
  55. doi request reprint Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors
    Concettina La Motta
    Dipartimento di Scienze Farmaceutiche, Universita di Pisa, Via Bonanno, 6, 56126 Pisa, Italy
    J Med Chem 52:1681-92. 2009
    ....
  56. ncbi request reprint The pharmacokinetics of ilaprazole for gastro-esophageal reflux treatment
    Nicola De Bortoli
    University of Pisa, Division of Gastroenterology, Department of Internal Medicine, Pisa, Italy
    Expert Opin Drug Metab Toxicol 9:1361-9. 2013
    ..Recently, a new PPI, ilaprazole , at oral doses of 10 mg has shown higher suppression of gastric acid secretion, more prolonged plasma half-life, and similar safety compared to 20 mg omeprazole...
  57. ncbi request reprint Drug therapeutic failures in emergency department patients. A university hospital experience
    Alessandro Franceschi
    Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Pisa, Italy
    Pharmacol Res 49:85-91. 2004
    ..In conclusion, our results suggest that DTFs represent an important cause of emergency department admission, particularly in elderly subjects treated with pharmacological associations...
  58. ncbi request reprint Healthy volunteers and early phases of clinical experimentation
    Giuseppe Pasqualetti
    Clinical Pharmacology Centre for Drug Experimentation Pisa University Hospital, Via Roma 67, 56100, Pisa, Italy
    Eur J Clin Pharmacol 66:647-53. 2010
    ....
  59. ncbi request reprint Effects of a bicarbonate-alkaline mineral water on gastric functions and functional dyspepsia: a preclinical and clinical study
    Michele Bertoni
    Gastroenterology Unit, University Hospital of Pisa, Pisa, Italy
    Pharmacol Res 46:525-31. 2002
    ..The preclinical study suggests that the clinical actions of Uliveto water depend mainly on its ability to enhance gastric motor and secretory functions...
  60. ncbi request reprint Platelet serotonin transporter in patients with diarrhea-predominant irritable bowel syndrome both before and after treatment with alosetron
    Massimo Bellini
    Section of Gastroenterology, Department of Internal Medicine, University of Pisa, Ospedale Santa Chiara, Via Roma 67, 56126 Pisa, Italy
    Am J Gastroenterol 98:2705-11. 2003
    ....
  61. ncbi request reprint Fatal hepatitis after long-term pulse itraconazole treatment for onychomycosis
    Marco Tuccori
    Department of Internal Medicine, Division of Pharmacology and Chemotherapy, University of Pisa, Pisa, Italy
    Ann Pharmacother 42:1112-7. 2008
    ..To report the occurrence of acute cytolytic hepatitis in a patient exposed to pulse itraconazole therapy for 24 weeks and provide a concise review of the literature on cases of itraconazole-induced hepatitis...
  62. ncbi request reprint Gabapentin-induced severe myopathy
    Marco Tuccori
    Tuscan Regional Center for Pharmacovigilance, University of Pisa, Pisa, Italy
    Ann Pharmacother 41:1301-5. 2007
    ..To report and discuss a case of rhabdomyolysis in an elderly patient with neuropathic pain who was treated with gabapentin...
  63. pmc Distribution of azithromycin in plasma and tonsil tissue after repeated oral administration of 10 or 20 milligrams per kilogram in pediatric patients
    Corrado Blandizzi
    Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University Hospital of Pisa, Pisa, Italy
    Antimicrob Agents Chemother 46:1594-6. 2002
    ..5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribution of azithromycin, suggesting the achievement of enhanced therapeutic concentrations at infective sites of the upper respiratory tract...
  64. ncbi request reprint Cholinergic toxic syndrome by the anticancer drug irinotecan: acetylcholinesterase does not play a major role
    Corrado Blandizzi
    Interdepartmental Center for Research in Clinical Pharmacology and Experimental Therapeutics, University of Pisa, Italy
    Clin Pharmacol Ther 71:263-71. 2002
    ....
  65. ncbi request reprint Acute severe myopathy following a single infusion of omeprazole
    Marco Tuccori
    Ann Pharmacother 40:352-3. 2006