Nicoletta Bivi

Summary

Affiliation: University of Udine
Country: Italy

Publications

  1. pmc Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection
    Nicoletta Bivi
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe, 33100, Udine, Italy
    Genome Biol 10:R93. 2009
  2. ncbi Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell lines
    Milena Romanello
    Department of Biomedical Sciences and Technologies and the Center for Regenerative Medicine CIME, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Bone 39:739-53. 2006
  3. pmc APE1/Ref-1 regulates PTEN expression mediated by Egr-1
    Damiano Fantini
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Free Radic Res 42:20-9. 2008
  4. doi Shotgun proteomics analysis reveals new unsuspected molecular effectors of nitrogen-containing bisphosphonates in osteocytes
    Nicoletta Bivi
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    J Proteomics 74:1113-22. 2011
  5. ncbi Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathway
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    J Cell Physiol 209:44-55. 2006
  6. doi Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonates
    Nicoletta Bivi
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy, Shimadzu Research Laboratory Europe, Manchester, UK
    J Proteome Res 8:1131-42. 2009
  7. pmc Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    Nucleic Acids Res 33:4379-94. 2005

Collaborators

Detail Information

Publications7

  1. pmc Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection
    Nicoletta Bivi
    Department of Biomedical Sciences and Technologies, University of Udine, Piazzale Kolbe, 33100, Udine, Italy
    Genome Biol 10:R93. 2009
    ..Strains carrying deletions in genes encoding potential drug targets show a variation of the intensity of their corresponding barcodes on the hybridization array over the time...
  2. ncbi Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell lines
    Milena Romanello
    Department of Biomedical Sciences and Technologies and the Center for Regenerative Medicine CIME, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Bone 39:739-53. 2006
    ..These findings show that bisphosphonates, by inducing ATP release, may also act through nucleotide receptors signaling leading to ERKs activation and may exert their mitogenic role on osteoblasts through the involvement of Hsp90...
  3. pmc APE1/Ref-1 regulates PTEN expression mediated by Egr-1
    Damiano Fantini
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    Free Radic Res 42:20-9. 2008
    ..Thus, the data open new perspectives in the comprehension of the many functions exerted by APE1 in controlling cell response to oxidative stress...
  4. doi Shotgun proteomics analysis reveals new unsuspected molecular effectors of nitrogen-containing bisphosphonates in osteocytes
    Nicoletta Bivi
    Department of Medical and Biological Sciences, University of Udine, 33100 Udine, Italy
    J Proteomics 74:1113-22. 2011
    ..In conclusion, these findings unveil novel functions targeted by N-BPs in osteocytes and could be useful to design novel pharmaceutical compounds...
  5. ncbi Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathway
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy
    J Cell Physiol 209:44-55. 2006
    ..Accordingly, these two receptors resulted significantly upregulated in sample biopsies from different thyroid tumors...
  6. doi Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonates
    Nicoletta Bivi
    Department of Biomedical Sciences and Technologies, University of Udine, Udine, Italy, Shimadzu Research Laboratory Europe, Manchester, UK
    J Proteome Res 8:1131-42. 2009
    ..Data validated using gel imaging in combination with the GLaD post digestion isotopic labeling method provide the molecular basis for understanding the role of bisphosphonates as antiapoptotic drugs for osteocytes...
  7. pmc Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
    Alex Pines
    Department of Biomedical Sciences and Technologies, University of Udine, 33100 Udine, Italy
    Nucleic Acids Res 33:4379-94. 2005
    ..Our data provide new insights into the complex mechanisms regulating APE1/Ref-1 functions...