Andrea Biondi

Summary

Affiliation: University of Milano-Bicocca
Country: Italy

Publications

  1. pmc The Eleventh International Childhood Acute Lymphoblastic Leukemia Workshop Report: Ponte di Legno, Italy, 6-7 May 2009
    A Biondi
    Pediatric Department, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
    Leukemia 23:2318-24. 2009
  2. pmc Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study
    Andrea Biondi
    Department of Paediatrics, University of Milano Bicocca, Monza, Italy
    Lancet Oncol 13:936-45. 2012
  3. doi Interleukin-17-producing T-helper cells as new potential player mediating graft-versus-host disease in patients undergoing allogeneic stem-cell transplantation
    Erica Dander
    Centro Ricerca M Tettamanti, Clinica Pediatrica Università degli Studi di Milano Bicocca, Monza, Italy
    Transplantation 88:1261-72. 2009
  4. doi Platelet-lysate-expanded mesenchymal stromal cells as a salvage therapy for severe resistant graft-versus-host disease in a pediatric population
    Giovanna Lucchini
    Clinica Pediatrica, Universita Milano Bicocca, Ospedale San Gerardo, Via Donizetti 106, Monza, MI, Italy
    Biol Blood Marrow Transplant 16:1293-301. 2010
  5. doi Regulatory T cells and extracorporeal photochemotherapy: correlation with clinical response and decreased frequency of proinflammatory T cells
    Iolanda Di Biaso
    Pediatric Department, Laboratory of Cell Therapy Stefano Verri, University of Milano Bicocca, San Gerardo Hospital, Monza Milan, Italy
    Transplantation 87:1422-5. 2009
  6. ncbi CD34+ stem cell recovery after positive selection of "overloaded" immunomagnetic columns
    Paolo Perseghin
    Servizio Trasfusionale, Unità di Aferesi e Criobiologia and Laboratorio di Manipolazione Cellulare e Terapia Genica S Verri, Ospedale S Gerardo, Monza, Italy
    Stem Cells Dev 14:740-3. 2005
  7. doi GMP-based CD133(+) cells isolation maintains progenitor angiogenic properties and enhances standardization in cardiovascular cell therapy
    Giuseppe Gaipa
    Laboratorio Interdipartimentale di Terapia Cellulare Stefano Verri, Azienda Ospedaliera San Gerardo, Monza, Milan, Italy
    J Cell Mol Med 14:1619-34. 2010
  8. doi Characterization of migratory activity and cytokine profile of helper and cytotoxic CMV-specific T-cell lines expanded by a selective peptide library
    Erica Dander
    Centro Ricerca M Tettamanti, Clinica Pediatrica Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Exp Hematol 36:473-85. 2008
  9. doi Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor
    Sarah Tettamanti
    Centro di Ricerca Matilde Tettamanti, Department of Paediatrics, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
    Br J Haematol 161:389-401. 2013
  10. doi Minimal residual disease before and after transplantation for childhood acute lymphoblastic leukaemia: is there any room for intervention?
    Adriana Balduzzi
    Clinica Pediatrica, Universita degli Studi di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Br J Haematol 164:396-408. 2014

Collaborators

Detail Information

Publications39

  1. pmc The Eleventh International Childhood Acute Lymphoblastic Leukemia Workshop Report: Ponte di Legno, Italy, 6-7 May 2009
    A Biondi
    Pediatric Department, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
    Leukemia 23:2318-24. 2009
    ..The meeting began with greetings by Professor Andrea Biondi. This report summarizes the data presented and the discussion in the meeting.
  2. pmc Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study
    Andrea Biondi
    Department of Paediatrics, University of Milano Bicocca, Monza, Italy
    Lancet Oncol 13:936-45. 2012
    ....
  3. doi Interleukin-17-producing T-helper cells as new potential player mediating graft-versus-host disease in patients undergoing allogeneic stem-cell transplantation
    Erica Dander
    Centro Ricerca M Tettamanti, Clinica Pediatrica Università degli Studi di Milano Bicocca, Monza, Italy
    Transplantation 88:1261-72. 2009
    ..Recently, T-helper (TH)-17 cells have been shown to play a central role in mediating several autoimmune diseases. The aim of our study was to investigate the relationship between TH-17 cells and GVHD occurring in transplanted patients...
  4. doi Platelet-lysate-expanded mesenchymal stromal cells as a salvage therapy for severe resistant graft-versus-host disease in a pediatric population
    Giovanna Lucchini
    Clinica Pediatrica, Universita Milano Bicocca, Ospedale San Gerardo, Via Donizetti 106, Monza, MI, Italy
    Biol Blood Marrow Transplant 16:1293-301. 2010
    ..Two patients developed chronic limited GVHD. This study underlines the safety of PL-expanded MSC use in children. MSC efficacy seems to be greater in aGVHD than in cGVHD, even after failure of multiple lines of immunosuppression...
  5. doi Regulatory T cells and extracorporeal photochemotherapy: correlation with clinical response and decreased frequency of proinflammatory T cells
    Iolanda Di Biaso
    Pediatric Department, Laboratory of Cell Therapy Stefano Verri, University of Milano Bicocca, San Gerardo Hospital, Monza Milan, Italy
    Transplantation 87:1422-5. 2009
    ..Immune mechanisms of extracorporeal photochemotherapy (ECP) in refractory/resistant graft-versus-host disease (GvHD) are complex. We have previously analyzed the role of CD4CD25Foxp3 regulatory T cells (T-regs)...
  6. ncbi CD34+ stem cell recovery after positive selection of "overloaded" immunomagnetic columns
    Paolo Perseghin
    Servizio Trasfusionale, Unità di Aferesi e Criobiologia and Laboratorio di Manipolazione Cellulare e Terapia Genica S Verri, Ospedale S Gerardo, Monza, Italy
    Stem Cells Dev 14:740-3. 2005
    ..In conclusion, levels of both total nucleated cells and CD34+ can be processed in a single procedure with satisfactory and similar CD34+ cell recovery when these columns are loaded with up to two times as many cells as recommended...
  7. doi GMP-based CD133(+) cells isolation maintains progenitor angiogenic properties and enhances standardization in cardiovascular cell therapy
    Giuseppe Gaipa
    Laboratorio Interdipartimentale di Terapia Cellulare Stefano Verri, Azienda Ospedaliera San Gerardo, Monza, Milan, Italy
    J Cell Mol Med 14:1619-34. 2010
    ....
  8. doi Characterization of migratory activity and cytokine profile of helper and cytotoxic CMV-specific T-cell lines expanded by a selective peptide library
    Erica Dander
    Centro Ricerca M Tettamanti, Clinica Pediatrica Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Exp Hematol 36:473-85. 2008
    ..For this purpose, we established a method for generating both anti-CMV CD4 and CD8 T cells following Good Manufacturing Practice indications, and we extensively characterized their immune functions...
  9. doi Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor
    Sarah Tettamanti
    Centro di Ricerca Matilde Tettamanti, Department of Paediatrics, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
    Br J Haematol 161:389-401. 2013
    ....
  10. doi Minimal residual disease before and after transplantation for childhood acute lymphoblastic leukaemia: is there any room for intervention?
    Adriana Balduzzi
    Clinica Pediatrica, Universita degli Studi di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Br J Haematol 164:396-408. 2014
    ..Additional intensified chemotherapy and modulation of immunosuppression may reduce relapse risk and improve ultimate outcome...
  11. pmc New advances in leukaemia immunotherapy by the use of Chimeric Artificial Antigen Receptors (CARs): state of the art and perspectives for the near future
    Ettore Biagi
    Centro di Ricerca Fondazione Matilde Tettamanti, Clinica Pediatrica Azienda Ospedaliera San Gerardo, Universita Milano Bicocca, Monza, Italy
    Ital J Pediatr 37:46. 2011
    ..This review will discuss the main application of this approach particularly focusing on the paediatric setting, raising advantages and disadvantages and discussing relevant perspectives of use in the nearest future...
  12. doi Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study
    Valentino Conter
    Department of Pediatrics, University of Milano Bicocca, Ospedale S Gerardo, Monza, Italy
    Blood 115:3206-14. 2010
    ..MRD response detected by sensitive quantitative PCR at 2 predefined TPs is highly predictive for relapse in childhood pB-ALL. The study is registered at http://clinicaltrials.gov: NCT00430118 for BFM and NCT00613457 for AIEOP...
  13. pmc What is the relevance of Ikaros gene deletions as a prognostic marker in pediatric Philadelphia-negative B-cell precursor acute lymphoblastic leukemia?
    Chiara Palmi
    Centro Ricerca Tettamanti, Clinica Pediatrica, Universita di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Haematologica 98:1226-31. 2013
    ..In conclusion, the need of and benefit from introducing IKZF1 deletions as an additional stratification marker for patients with Philadelphia-negative B-cell precursor acute lymphoblastic leukemia remain questionable. ..
  14. pmc In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor
    Greta Maria Paola Giordano Attianese
    Department of Pediatrics, University of Milano Bicocca, Milan, Italy
    Blood 117:4736-45. 2011
    ..CAR(+) T cells resulted in a significant delay in the growth of the MEC-1 CLL cell line. These data suggest that CD23.CAR(+) T cells represent a selective immunotherapy for the elimination of CD23(+) leukemic cells in patients with CLL...
  15. ncbi Extracorporeal photochemotherapy is accompanied by increasing levels of circulating CD4+CD25+GITR+Foxp3+CD62L+ functional regulatory T-cells in patients with graft-versus-host disease
    Ettore Biagi
    Pediatric Department, University of Milano Bicocca, San Gerardo Hospital, Milan, Italy
    Transplantation 84:31-9. 2007
    ..Extracorporeal photochemotherapy (ECP) produces clinical improvements in refractory/resistant graft-versus-host disease (GvHD). Immunological mechanisms of ECP are still under investigation...
  16. doi In vitro comparison of three different chimeric receptor-modified effector T-cell populations for leukemia cell therapy
    Irene Pizzitola
    Centro Ricerca M Tettamanti, Clinica Pediatrica, Ospedale San Gerardo, Universita Milano Bicocca, Monza, Italy
    J Immunother 34:469-79. 2011
    ....
  17. doi Prednisone induces immunophenotypic modulation of CD10 and CD34 in nonapoptotic B-cell precursor acute lymphoblastic leukemia cells
    Giuseppe Gaipa
    Centro Ricerca M Tettamanti, Clinica Pediatrica Università Milano Bicocca, Ospedale San Gerardo, Monza, MI, Italy
    Cytometry B Clin Cytom 74:150-5. 2008
    ..Immunophenotypic modulation is induced by steroids in pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients during remission induction therapy...
  18. doi Autologous purified peripheral blood stem cell transplantation compare to chemotherapy in childhood acute lymphoblastic leukemia after low-risk relapse
    Adriana Balduzzi
    Clinica Pediatrica, Ospedale San Gerardo, Universita degli Studi di Milano Bicocca, Monza, Italy
    Pediatr Blood Cancer 57:654-9. 2011
    ..The aim of this study is to provocatively assess the role of purified autologous transplantation compared with best chemotherapy results in the same setting...
  19. pmc Time point-dependent concordance of flow cytometry and real-time quantitative polymerase chain reaction for minimal residual disease detection in childhood acute lymphoblastic leukemia
    Giuseppe Gaipa
    M Tettamanti Research Center, Pediatric Clinic University of Milano Bicocca, Monza, Italy
    Haematologica 97:1582-93. 2012
    ..The aim of this study was to compare the performances of these two methodologies in the detection of minimal residual disease in childhood acute lymphoblastic leukemia...
  20. doi PAX5/TEL acts as a transcriptional repressor causing down-modulation of CD19, enhances migration to CXCL12, and confers survival advantage in pre-BI cells
    Grazia Fazio
    Centro Ricerca Tettamanti, Clinica Pediatrica, Universita di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Cancer Res 68:181-9. 2008
    ..Taken together, these phenomena likely represent key events in the process of B-cell transformation...
  21. ncbi Enhancement of the anti-leukemic activity of cytokine induced killer cells with an anti-CD19 chimeric receptor delivering a 4-1BB-zeta activating signal
    Virna Marin
    Centro Ricerca M Tettamanti, Clinica Pediatrica Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Exp Hematol 35:1388-97. 2007
    ..In this study, we sought to maximize the antileukemic activity of anti-CD19 receptor-modified CIK cells against B-lineage acute lymphoblastic leukemia (ALL)...
  22. ncbi The endocannabinoid anandamide neither impairs in vitro T-cell function nor induces regulatory T-cell generation
    Paolo Lissoni
    Division of Radiation Oncology, Clinica Pediatrica Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Anticancer Res 28:3743-8. 2008
    ..The present study aimed to evaluate the influence of the endogenous cannabinoid anandamide (AEA) on T-cell phenotype and function...
  23. doi Hurler disease bone marrow stromal cells exhibit altered ability to support osteoclast formation
    Francesca Gatto
    Pediatric Department, Dulbecco Telethon Institute at Tettamanti Research Center, University of Milano Bicocca, Monza, Italy
    Stem Cells Dev 21:1466-77. 2012
    ..However, MPS I BMSC displayed an increased capacity to support osteoclastogenesis, which may correlate with the up-regulation of the RANKL/RANK/OPG molecular pathway in MPS I BMSC compared with normal BMSC...
  24. doi Defining the correct role of minimal residual disease tests in the management of acute lymphoblastic leukaemia
    Giovanni Cazzaniga
    M Tettamanti Research Centre, Paediatric Clinic, University of Milano Bicocca, San Gerardo Hospital, Via Pergolesi 33, Monza, Italy
    Br J Haematol 155:45-52. 2011
    ....
  25. pmc Developmental origins and impact of BCR-ABL1 fusion and IKZF1 deletions in monozygotic twins with Ph+ acute lymphoblastic leukemia
    Giovanni Cazzaniga
    Centro Ricerca Tettamanti, Clinica Pediatrica, Universita di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Blood 118:5559-64. 2011
    ..IKZF1 is a secondary and probable postnatal mutation in these cases, and as a recurrent but alternative copy number change is associated with poor prognosis...
  26. doi Detection of minimal residual disease in pediatric acute lymphoblastic leukemia
    Giuseppe Gaipa
    M Tettamanti Research Center, Pediatric Clinic University of Milano Bicocca, Monza, Italy
    Cytometry B Clin Cytom 84:359-69. 2013
    ..The combined use of MRD and emerging information on genetic lesions of ALL offers the possibility of further refining risk-assignment approaches...
  27. doi The effects of propofol and ketamine on the cytokine levels of children with acute lymphoblastic leukemia
    Gianluca Bertolizio
    Department of Anesthesia, McGill University Health Centre, Montreal Children Hospital, Montreal, QC, Canada Department of Anaesthesia and Intensive Care, Anadolu Medical Center, Kocaeli, Turkey Dipartimento di Medicina Esperimentale, Universita Milano Bicocca, Milan U O Anestesia e Rianimazione I Centro di Ricerca M Tettamanti Clinica Pediatrica, Dipartimento Materno Infantile, Ospedale San Gerardo, Monza, Italy
    J Pediatr Hematol Oncol 35:e296-300. 2013
    ..These data suggest that sedation with propofol-ketamine combination may not affect the immediate outcome of children with ALL. ..
  28. doi Characterization of platelet lysate cultured mesenchymal stromal cells and their potential use in tissue-engineered osteogenic devices for the treatment of bone defects
    Agnese Salvade
    Laboratory of Cell Therapy Stefano Verri, Pediatric Department, Matilde Tettamanti Research Center, San Gerardo Hospital, University of Milano Bicocca, Monza, Italy
    Tissue Eng Part C Methods 16:201-14. 2010
    ..The present report offers a model of an MSC-based bioengineered device, using an hydroxyapatite clinical-grade scaffold, and supports its potential use in tissue engineering to repair bone defects...
  29. doi Integration of genomic and gene expression data of childhood ALL without known aberrations identifies subgroups with specific genetic hallmarks
    Silvia Bungaro
    Centro Ricerca Tettamanti, Clinica Pediatrica Università Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Genes Chromosomes Cancer 48:22-38. 2009
    ..Our findings demonstrate that integration of genomic analysis and gene expression profiling can identify genetic lesions undetected by routine methods and potential novel pathways involved in B-progenitor ALL pathogenesis...
  30. ncbi Role of treatment intensification in infants with acute lymphoblastic leukemia: results of two consecutive AIEOP studies
    Andrea Biondi
    Centro Ricerche Leucemie Infantili M Tettamanti, Clinica Pediatrica Università Milano Bicocca, Monza, Italy
    Haematologica 91:534-7. 2006
    ..The corresponding figures for patients treated in the ALL-91 high-risk protocol (reduced induction and nine blocks) were one of seven patients treated with chemotherapy only and none of two who were transplanted...
  31. doi Acute myeloid leukemia and novel biological treatments: monoclonal antibodies and cell-based gene-modified immune effectors
    Sarah Tettamanti
    Centro di Ricerca Matilde Tettamanti, Department of Pediatrics, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
    Immunol Lett 155:43-6. 2013
    ....
  32. ncbi Peripheral blood progenitor cell collection in chronic myeloid leukemia patients with complete cytogenetic response after treatment with imatinib mesylate
    Paolo Perseghin
    Department of Clinical Pathology Immunohematology and Transfusion Service, Therapeutic Apheresis Unit, San Gerardo de Tintori Hospital, Monza, Italy
    Transfusion 45:1214-20. 2005
    ..Nevertheless, some concerns exist about the duration of response to treatment and the onset of resistance to IM...
  33. doi Two cases of hepatic adenomas in patients with Wolf-Hirschhorn syndrome: a new rare complication?
    Giulia Prunotto
    Pediatric Genetic Unit, Pediatric Department of Monza Brianza per il Bambino e la sua Mamma MBBM Foundation, S Gerardo Hospital, Monza, Italy
    Am J Med Genet A 161:1759-62. 2013
    ..The clinical evolution of liver involvement was different between the two. We discuss the possibility of considering HA as a rare medical problem in the follow-up of WHS patients. © 2013 Wiley Periodicals, Inc...
  34. doi PTX3 as a potential novel tool for the diagnosis and monitoring of pulmonary fungal infections in immuno-compromised pediatric patients
    Ettore Biagi
    Department of Pediatrics, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
    J Pediatr Hematol Oncol 30:881-5. 2008
    ..Moreover, the response to the antifungal therapy correlated with normalization of PTX3 values. PTX3 may represent a useful tool for the diagnosis and monitoring of fungal infections in immuno-compromised children...
  35. ncbi Reconstitution of lymphocyte subpopulations in children with inherited metabolic storage diseases after haematopoietic cell transplantation
    Paola Corti
    Clinica Pediatrica, Universita di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Br J Haematol 130:249-55. 2005
    ..Because of the unique graft manipulation, the pace of lymphocyte reconstitution was particularly slow, suggesting that these patients are at a significantly increased risk of infections for up to 2 years after HCT...
  36. ncbi Chimeric T-cell receptors: new challenges for targeted immunotherapy in hematologic malignancies
    Ettore Biagi
    Centro di Ricerca Matilde Tettamanti, Department of Pediatrics, University of Milano Bicocca, San Gerardo Hospital, Monza, Milan, Italy
    Haematologica 92:381-8. 2007
    ....
  37. doi Novel clinical trials for pediatric leukemias: lessons learned from genomic analyses
    Andrea Biondi
    1Department of Pediatrics and Centro Ricerca Tettamanti, University of Milano Bicocca, S Gerardo Hospital, Fondazione MBBM, Monza, Italy
    Hematology Am Soc Hematol Educ Program 2013:612-9. 2013
    ..To facilitate continued progress, this new scenario will raise methodological issues in study design and the need for collaboration across large, well-characterized patient populations. ..
  38. doi A boy with Burkitt lymphoma associated with Noonan syndrome due to a mutation in RAF1
    Paola Cianci
    Pediatric Genetic Unit, Pediatric Department at Monza Brianza per il Bambino e la sua Mamma MBBM Foundation, S Gerardo Hospital, Monza, Italy
    Am J Med Genet A 161:1401-4. 2013
    ....
  39. ncbi Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR
    Vincenzo Rossi
    Centro Ricerca M Tettamanti, Clinica Pediatrica Università di Milano Bicocca, Monza, Italy
    Methods Mol Med 125:115-26. 2006
    ....