A R Bilia


Affiliation: University of Florence
Country: Italy


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    Bilia A, Lazari D, Messori L, Taglioli V, Temperini C, Vincieri F. Simple and rapid physico-chemical methods to examine action of antimalarial drugs with hemin: its application to Artemisia annua constituents. Life Sci. 2002;70:769-78 pubmed
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    Bilia A, Bergonzi M, Mazzi G, Vincieri F. NMR spectroscopy: a useful tool for characterisation of plant extracts, the case of supercritical CO2 arnica extract. J Pharm Biomed Anal. 2002;30:321-30 pubmed
    ..Identification of constituents was performed by combining literature data and information obtained by 2D-NMR experiments. ..
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    Bilia A, Bergonzi M, Gallori S, Mazzi G, Vincieri F. Stability of the constituents of Calendula, milk-thistle and passionflower tinctures by LC-DAD and LC-MS. J Pharm Biomed Anal. 2002;30:613-24 pubmed
    ..Thus, shelf-lives at 25 degrees C of the most stable tincture (Passionflower 60% v/v) was about 6 months and only about 3 months the stability of Milk-thistle tinctures. ..
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    Bilia A, Bergonzi M, Mazzi G, Vincieri F. Development and stability of semisolid preparations based on a supercritical CO2 Arnica extract. J Pharm Biomed Anal. 2006;41:449-54 pubmed
    ..The cetomacrogol showed the best release profile in the in vitro test, while in the in vivo test the best preparation resulted polysorbate 60 and polawax...
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    Bilia A, Giomi M, Innocenti M, Gallori S, Vincieri F. HPLC-DAD-ESI-MS analysis of the constituents of aqueous preparations of verbena and lemon verbena and evaluation of the antioxidant activity. J Pharm Biomed Anal. 2008;46:463-70 pubmed
    ..In addition, the antioxidant property of the lemon verbena infusion was evaluated by the DPPH test using Trolox as the reference compound...
  6. Piazzini V, Landucci E, Graverini G, Pellegrini Giampietro D, Bilia A, Bergonzi M. Stealth and Cationic Nanoliposomes as Drug Delivery Systems to Increase Andrographolide BBB Permeability. Pharmaceutics. 2018;10: pubmed publisher
    ..The presence of positive charge increased the cellular internalization of nanoparticles. (4) Conclusions: This study shows that developed liposomes might be ideal candidates for brain delivery of AG. ..
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    Bilia A, Bergonzi M, Mazzi G, Vincieri F. Analysis and stability of the constituents of artichoke and St. John's wort tinctures by HPLC-DAD and HPLC-MS. Drug Dev Ind Pharm. 2002;28:609-19 pubmed
    ..From the results it was evidenced that constituent content depends on the solvent used for the extraction. The stability was also shown to be very different and seems to be related to the water content of the tinctures. ..
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    Bilia A, Gallon S, Vincieri F. Kava-kava and anxiety: growing knowledge about the efficacy and safety. Life Sci. 2002;70:2581-97 pubmed
    ..On the other hand, it should be possible that unknown or unexpected constituents are the responsible or contributed to the liver toxicity. ..
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    Bilia A, Melillo de Malgalhaes P, Bergonzi M, Vincieri F. Simultaneous analysis of artemisinin and flavonoids of several extracts of Artemisia annua L. obtained from a commercial sample and a selected cultivar. Phytomedicine. 2006;13:487-93 pubmed
    ..Qualitative and quantitative results obtained using an HPLC method are described, which will be useful for developing highly effective herbal drug preparations. ..

More Information


  1. Corrêa M, Ventura T, Muzitano M, Dos Anjos da Cruz E, Bergonzi M, Bilia A, et al. Suppressive effects of Vochysia divergens aqueous leaf extract and its 5-methoxyflavone on murine macrophages and lymphocytes. J Ethnopharmacol. 2018;221:77-85 pubmed publisher
    ..In addition, this study contributes to the knowledge of the pharmacological properties of 5-methoxy flavones, a poorly investigated subclass of flavonoids. ..
  2. Leto I, Coronnello M, Righeschi C, Bergonzi M, Mini E, Bilia A. Enhanced Efficacy of Artemisinin Loaded in Transferrin-Conjugated Liposomes versus Stealth Liposomes against HCT-8 Colon Cancer Cells. ChemMedChem. 2016;11:1745-51 pubmed publisher