Generoso Bevilacqua

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. pmc The role of the pathologist in tissue banking: European Consensus Expert Group Report
    Generoso Bevilacqua
    Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Medical School, Via Roma 57, 56126 Pisa, Italy
    Virchows Arch 456:449-54. 2010
  2. ncbi request reprint p53 inactivation is a rare event in familial breast tumors negative for BRCA1 and BRCA2 mutations
    Elisa Sensi
    Section of Oncogenetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University Hospital of Pisa, University of Pisa, Pisa, Italy
    Breast Cancer Res Treat 82:1-9. 2003
  3. ncbi request reprint RNA-based analysis of BRCA1 and BRCA2 gene alterations
    Fabrizia Bonatti
    Section of Genetic Oncology, Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Via Roma, Pisa, Italy
    Cancer Genet Cytogenet 170:93-101. 2006
  4. ncbi request reprint Markers of cell proliferation, apoptosis, and angiogenesis in thyroid adenomas: a comparative immunohistochemical and genetic investigation of functioning and nonfunctioning nodules
    Paolo Viacava
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa, Italy
    Thyroid 17:191-7. 2007
  5. doi request reprint PIK3CA in breast carcinoma: a mutational analysis of sporadic and hereditary cases
    Angela Michelucci
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, University Hospital of Pisa, Italy
    Diagn Mol Pathol 18:200-5. 2009
  6. doi request reprint Are the clinical and pathological features of differentiated thyroid carcinoma really changed over the last 35 years? Study on 4187 patients from a single Italian institution to answer this question
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 95:1516-27. 2010
  7. ncbi request reprint P53 gene status in patients with advanced serous epithelial ovarian cancer in relation to response to paclitaxel- plus platinum-based chemotherapy and long-term clinical outcome
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Anticancer Res 26:687-93. 2006
  8. ncbi request reprint Angiogenesis and VEGF expression in pre-invasive lesions of the human breast
    Paolo Viacava
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and Pisa University Hospital, Pisa, Italy
    J Pathol 204:140-6. 2004
  9. doi request reprint Torquetenovirus infection and ciliary dysmotility in children with recurrent pneumonia
    Massimo Pifferi
    Department of Pediatrics, Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa, Pisa, Italy
    Pediatr Infect Dis J 27:413-8. 2008
  10. ncbi request reprint Microvessel density in human normal and neoplastic parathyroids
    Paolo Viacava
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Via Roma, 55, 56126 Pisa, Italy
    Endocr Pathol 17:175-81. 2006

Collaborators

Detail Information

Publications47

  1. pmc The role of the pathologist in tissue banking: European Consensus Expert Group Report
    Generoso Bevilacqua
    Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Medical School, Via Roma 57, 56126 Pisa, Italy
    Virchows Arch 456:449-54. 2010
    ....
  2. ncbi request reprint p53 inactivation is a rare event in familial breast tumors negative for BRCA1 and BRCA2 mutations
    Elisa Sensi
    Section of Oncogenetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University Hospital of Pisa, University of Pisa, Pisa, Italy
    Breast Cancer Res Treat 82:1-9. 2003
    ..While loss of p53 checkpoint control is likely to be an important step in the molecular pathogenesis of BRCA1-associated cancers, our data seem to indicate a p53-independent molecular mechanism underlying BRCAx neoplastic transformation...
  3. ncbi request reprint RNA-based analysis of BRCA1 and BRCA2 gene alterations
    Fabrizia Bonatti
    Section of Genetic Oncology, Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Via Roma, Pisa, Italy
    Cancer Genet Cytogenet 170:93-101. 2006
    ..BRCA1 c.IVS17 + 6C>G, BRCA2 c.IVS12-9del4, and BRCA2 IVS1-9del3 represent rare variants, not disrupting normal mRNA processing. The last two BRCA2 genetic variants had not been reported in the Breast Cancer Information Core BIC database...
  4. ncbi request reprint Markers of cell proliferation, apoptosis, and angiogenesis in thyroid adenomas: a comparative immunohistochemical and genetic investigation of functioning and nonfunctioning nodules
    Paolo Viacava
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa, Italy
    Thyroid 17:191-7. 2007
    ....
  5. doi request reprint PIK3CA in breast carcinoma: a mutational analysis of sporadic and hereditary cases
    Angela Michelucci
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, University Hospital of Pisa, Italy
    Diagn Mol Pathol 18:200-5. 2009
    ..The PIK3CA mutation seems to characterize the luminal-type BC, in both sporadic and BRCA2 mutated forms, and is absent in the basal-type BC, in both the sporadic and BRCA1 mutated forms...
  6. doi request reprint Are the clinical and pathological features of differentiated thyroid carcinoma really changed over the last 35 years? Study on 4187 patients from a single Italian institution to answer this question
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 95:1516-27. 2010
    ..In the last decades, a marked increased prevalence of differentiated thyroid cancer (DTC) has been observed worldwide. The aim of this study was to evaluate the changing features of DTC referred to our institution between 1969 and 2004...
  7. ncbi request reprint P53 gene status in patients with advanced serous epithelial ovarian cancer in relation to response to paclitaxel- plus platinum-based chemotherapy and long-term clinical outcome
    Angiolo Gadducci
    Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
    Anticancer Res 26:687-93. 2006
    ....
  8. ncbi request reprint Angiogenesis and VEGF expression in pre-invasive lesions of the human breast
    Paolo Viacava
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and Pisa University Hospital, Pisa, Italy
    J Pathol 204:140-6. 2004
    ..No correlation was found between VEGF expression and the degree and/or type of vascularization...
  9. doi request reprint Torquetenovirus infection and ciliary dysmotility in children with recurrent pneumonia
    Massimo Pifferi
    Department of Pediatrics, Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa, Pisa, Italy
    Pediatr Infect Dis J 27:413-8. 2008
    ....
  10. ncbi request reprint Microvessel density in human normal and neoplastic parathyroids
    Paolo Viacava
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Via Roma, 55, 56126 Pisa, Italy
    Endocr Pathol 17:175-81. 2006
    ..Therefore, angiogenesis in parathyroid adenomas and carcinomas appears to be an early event, which does not follow a parallel increase in size...
  11. ncbi request reprint Different expressivity of BRCA1 and BRCA2: analysis of 179 Italian pedigrees with identified mutation
    Paolo Aretini
    Section of Oncogenetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa, Italy
    Breast Cancer Res Treat 81:71-9. 2003
    ..Proportion of ovarian cancer was increased in the 5' portion of BRCA1, and presence of prostate or pancreatic cancer in a family was correlated with presence of ovarian cancer in BRCA2...
  12. ncbi request reprint Genetic alterations in hereditary breast cancer
    G Cipollini
    Section of Onco Genetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and University Hospital of Pisa, Pisa, Italy
    Ann Oncol 15:I7-I13. 2004
    ..The presence of founder mutations has practical implications for genetic testing...
  13. ncbi request reprint Collection, banking and diagnostic archiving of tissues
    G Bevilacqua
    Divisione di Anatomia Patologica e Diagnostica Molecolare ed Ultrastrutturale, Universita di Pisa, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Pathologica 100:49-54. 2008
  14. ncbi request reprint Cyclins of phases G1, S and G2/M are overexpressed in aneuploid mammary carcinomas
    P Collecchi
    Department of Oncology, Division of Pathology, University of Pisa, Pisa, Italy
    Cytometry 42:254-60. 2000
    ..Furthermore, overexpression of these proteins is related to the aneuploid and high proliferative activity of human mammary carcinomas...
  15. ncbi request reprint Cyclin D1 and retinoblastoma susceptibility gene alterations in non-small cell lung cancer
    A Marchetti
    Department of Oncology, University of Pisa, Italy
    Int J Cancer 75:187-92. 1998
    ..Abnormalities of cyclin D1 and/or RB at the gene and/or expression level were present in more than 90% of cases, stressing that cyclin D1 and/or RB alterations represent an important step in lung tumorigenesis...
  16. ncbi request reprint FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations
    A Marchetti
    Department of Oncology, University of Pisa, Italy
    J Pathol 184:240-6. 1998
    ..In conclusion, these results indicate that FHIT alterations are frequently involved in BAC tumourigenesis and that genetic changes in the p53 and K-ras genes can distinguish between different histotypes of BAC...
  17. ncbi request reprint Thrombospondins I and II messenger RNA expression in lung carcinoma: relationship with p53 alterations, angiogenic growth factors, and vascular density
    G Fontanini
    Department of Oncology, University of Pisa, Italy
    Clin Cancer Res 5:155-61. 1999
    ....
  18. ncbi request reprint Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract
    M A Caligo
    Department of Oncology, Division of Pathology, Labaratory of Molecular Genetics, University of Pisa, I 56126 Pisa, Italy
    Oncol Rep 7:1371-5. 2000
    ..Mutations in the repeated nucleotide stretches within the coding sequences of TGFbetaRII, IGFRII and bax genes were found only in colon tumors with a high unstable phenotype (more than 3 microsatellite loci altered)...
  19. ncbi request reprint Bcl-2 expression in pancreas development and pancreatic cancer progression
    D Campani
    Department of Oncology, Division of Pathology, University of Pisa, Via Roma 57, 56126 Pisa, Italy
    J Pathol 194:444-50. 2001
    ....
  20. ncbi request reprint Insulin-like growth factor II (IGF-II) immunohistochemistry in breast cancer: relationship with the most important morphological and biochemical prognostic parameters
    C Giani
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Int J Biol Markers 17:90-5. 2002
    ..These preliminary results indicate that IGF-II expression in breast cancer is connected with two important regulators of breast cancer growth and differentiation...
  21. ncbi request reprint Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma
    Elisa Sensi
    Section of Oncogenetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and University Hospital of Pisa, Italy
    Breast Cancer Res Treat 87:197-201. 2004
    ..No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target in hereditary breast cancer...
  22. doi request reprint Dysregulated PI3K/Akt/PTEN pathway is a marker of a short disease-free survival in node-negative breast carcinoma
    Alessandra Capodanno
    Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Pisa, Italy
    Hum Pathol 40:1408-17. 2009
    ....
  23. ncbi request reprint Papillary lesions of the breast: a molecular progression?
    Claudio Di Cristofano
    Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and University Hospital of Pisa, Italy
    Breast Cancer Res Treat 90:71-6. 2005
    ..LOH at TP53 locus was also analyzed throughout lesions...
  24. doi request reprint Establishment and characterization of 4 new human pancreatic cancer cell lines: evidences of different tumor phenotypes
    Barbara Chifenti
    Division of Surgical, Regional Referral Center for Pancreatic Diseases Treatment, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Pisa, Italy
    Pancreas 38:184-96. 2009
    ..Pancreatic cancer still remains a challenge for its biological complexity and lack of effective therapeutic strategies. Establishing new pancreatic cancer cell lines is therefore of paramount importance to clarify its biology...
  25. ncbi request reprint MMTV-like sequences in human breast cancer: a fluorescent PCR/laser microdissection approach
    F Zammarchi
    Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Italy
    J Pathol 209:436-44. 2006
    ..This approach might be successfully used in large molecular studies that aim to investigate the hypothesis of a retroviral aetiology of human breast cancer...
  26. ncbi request reprint Haplotype analysis of BRCA1 gene reveals a new gene rearrangement: characterization of a 19.9 KBP deletion
    Mariella Tancredi
    Section of Oncogenetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa and University Hospital of Pisa, Italy
    Eur J Hum Genet 12:775-7. 2004
    ....
  27. pmc Definition of the microvascular pattern of the normal human adult mammary gland
    Antonio G Naccarato
    Department of Oncology, Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa, Italy
    J Anat 203:599-603. 2003
    ..4 +/- 1.5) in lobules and ducts, respectively. PR expression levels were in the range 10-13% (11.1 +/- 1.6) and 14-17% (15.2 +/- 1.4), respectively. No correlation was found between ER/PR expression and vascularization parameters...
  28. ncbi request reprint High level of messenger RNA for BRMS1 in primary breast carcinomas is associated with poor prognosis
    Grazia Lombardi
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and Pisa University Hospital, Via Roma 57, 56126 Pisa, Italy
    Int J Cancer 120:1169-78. 2007
    ....
  29. doi request reprint Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma
    Niccola Funel
    Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Surgical Pathology, Molecular and Ultrastructural Pathology, University of Pisa, Pisa, Italy
    Lab Invest 88:773-84. 2008
    ..The use of these ex vivo techniques for molecular analysis of tumors therefore appears to be of some value in implementing the clinical management of PDAC...
  30. doi request reprint A morpho-molecular diagnosis of papillary thyroid carcinoma: BRAF V600E detection as an important tool in preoperative evaluation of fine-needle aspirates
    Ivo Marchetti
    University of Pisa and Pisa University Hospital, Italy
    Thyroid 19:837-42. 2009
    ..We also sought to determine if assessing the presence of BRAF gene mutations in preoperative FNA cytology slides would provide diagnostic information for FNA samples with a reading of indeterminate or suspicious thyroid lesions...
  31. ncbi request reprint Identification of novel alternatively spliced BRCA1-associated RING domain (BARD1) messenger RNAs in human peripheral blood lymphocytes and in sporadic breast cancer tissues
    Grazia Lombardi
    Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and Pisa University Hospital, Via Roma 57, 56126 Pisa, Italy
    Genes Chromosomes Cancer 46:791-5. 2007
    ..However, we were unable to identify either qualitatively or quantitatively tumor-specific expression patterns of the identified BARD1 splicing variants...
  32. ncbi request reprint HPV testing and Pap test: role for a combined approach in a non-screened population
    I Marchetti
    Section of Cytopathology, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa University Hospital, Pisa, Italy
    Int J Biol Markers 21:149-56. 2006
    ..0%. This study confirms the limitations of screening programs based on Pap test only. Our results suggest, in fact, that adding the HPV test to primary screening could increase the yield of preinvasive cervical lesions...
  33. doi request reprint Reconstructing the genealogy of a BRCA1 founder mutation by phylogenetic analysis
    F Marroni
    Center of Statistical Genetics, University of Pisa, Pisa, Italy
    Ann Hum Genet 72:310-8. 2008
    ..The 1499insA mutation shared by the investigated subjects was estimated to be present in an individual living about 30 generations ago (95% CL 22-56), or 750 years (95% CL 550-1,400)...
  34. ncbi request reprint The NM23 gene maps to human chromosome band 17q22 and shows a restriction fragment length polymorphism with BglII
    L Varesco
    Institute of Pathological Anatomy and Histology, University of Pisa, Italy
    Genes Chromosomes Cancer 4:84-8. 1992
    ..The mapping of NM23-Hl by panels of rodent-human somatic cell hybrids and in situ hybridization showed that the gene is located in human chromosome band 17q22. A two-allele polymorphism with BglII was demonstrated...
  35. ncbi request reprint Contrast-enhanced MR imaging in patients with BI-RADS 3-5 microcalcifications
    A Cilotti
    Division of Diagnostic and Interventional Radiology, University of Pisa, and Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Radiol Med 112:272-86. 2007
    ..The aim of this study was to evaluate the role of magnetic resonance imaging (MRI) in patients with microcalcifications classed as Breast Imaging Reporting and Data Systems (BI-RADS) 3-5...
  36. ncbi request reprint Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in Italian BRCA1/2 carriers
    C Pepe
    Section of Oncogenetics, Division of Pathology, Department of Oncology, University of Pisa, Via Roma, 57, PI, I 56126 Pisa, Italy
    Breast Cancer Res Treat 103:29-36. 2007
    ..The presence of 677T allele confers an increased risk of breast cancer in BRCA1 carriers (P = 0.007) and the presence of 1298C allele confers an increased risk of breast cancer in sporadic cases (P = 0.015)...
  37. ncbi request reprint The Italian multi-centre project on evaluation of MRI and other imaging modalities in early detection of breast cancer in subjects at high genetic risk
    F Podo
    Istituto Superiore di Sanita, Laboratorio di Biologia Cellulare, Roma, Italy
    J Exp Clin Cancer Res 21:115-24. 2002
    ..These preliminary results confirmed that MRI is a very useful tool to screen subjects at high genetic risk for breast carcinoma, not only in pre-, but also in post-menopausal age, with a low probability of false positive cases...
  38. ncbi request reprint Breast MR imaging screening in eight women proved or suspected to be carriers of BRCA1&2 gene mutations
    A Cilotti
    Division of Diagnostic and Interventional Radiology, Dept of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa and Azienda Ospedaliera Pisana, Pisa, Italy
    J Exp Clin Cancer Res 21:137-40. 2002
    ..MR imaging proved itself to be a reliable technique in familial breast cancer high risk women...
  39. ncbi request reprint [Pursuing the future]
    G Bevilacqua
    Pathologica 95:4-8. 2003
  40. ncbi request reprint An observational study of surfactant treatment in infants of 23-30 weeks' gestation: comparison of prophylaxis and early rescue
    G Bevilacqua
    Department of Gynecological, Obstetrical and Neonatological Sciences, Section of Child Health and Neonatology, University of Parma, Italy
    J Matern Fetal Neonatal Med 14:197-204. 2003
    ..To test the clinical efficacy of exogenous surfactant for treatment of neonatal respiratory distress syndrome (RDS)...
  41. pmc Evaluation of widely used models for predicting BRCA1 and BRCA2 mutations
    F Marroni
    J Med Genet 41:278-85. 2004
  42. ncbi request reprint The policy of antenatal corticosteroid administration in Italy vs. other European countries
    Ev Cosmi
    Institute of Gynecology, Perinatology and Child Health, University La Sapienza, Rome, Italy
    J Matern Fetal Neonatal Med 16:1-3. 2004
    ..To describe antenatal corticosteroid policies in Italy in comparison with other European countries, as inferred by the published data of the EURAIL Study Group (1999)...
  43. ncbi request reprint The web survey network of sudden infant death syndrome and apparent life-threatening events in the Emilia-Romagna region
    S Parmigiani
    Department of Gynecological, Obstetrical and Neonatological Sciences, Section of Child Welfare and Neonatal Medicine, SIDS Center, Parma, Italy
    J Matern Fetal Neonatal Med 16:37-40. 2004
    ..The characteristics of the network that has just started to collect data, as well its future developmental aspects, are discussed...
  44. ncbi request reprint Neonatal seizures in preterm infants: clinical outcome and relationship with subsequent epilepsy
    F Pisani
    Child Neuropsychiatric Unit, Department of Pediatrics, Section of Child Welfare and Neonatal Medicine, University of Parma, Parma, Italy
    J Matern Fetal Neonatal Med 16:51-3. 2004
    ....
  45. ncbi request reprint [Guidelines for health surveillance of health care workers exposed to biological risks set up by the Italian Society for Occupational Health and Industrial Hygiene: application in health facilities of the Regional Health Administration--District No. 7, An
    A Copertaro
    Ufficio del Medico Competente ASUR, Zona Territoriale 7, Ancona Ospedale di Loreto
    Med Lav 96:52-62. 2005
    ....
  46. ncbi request reprint [Perinatal risk factors for infection in the newborn. Multicenter clinico-epidemiologic investigation]
    G Bevilacqua
    Dipartimento di Scienze Ginecologiche, Ostetriche e di Neonatologia, Universita di Parma
    Pediatr Med Chir 27:31-8. 2005
    ....
  47. ncbi request reprint Breast carcinoma with osteoclast-like giant cells: immunohistochemical and ultrastructural study of a case and review of the literature
    P Viacava
    Institute of Pathology, University of Pisa, Italy
    Tumori 81:135-41. 1995
    ..The patient was alive and well 30 months following the operation. A review of the literature concerning breast carcinoma with OGCs is also presented...