Research Topics
Species | Generoso BevilacquaSummaryAffiliation: University of Pisa Country: Italy Publications
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Detail Information
Publications
The role of the pathologist in tissue banking: European Consensus Expert Group ReportGeneroso Bevilacqua
Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Medical School, Via Roma 57, 56126 Pisa, Italy
Virchows Arch 456:449-54. 2010....
p53 inactivation is a rare event in familial breast tumors negative for BRCA1 and BRCA2 mutationsElisa Sensi
Section of Oncogenetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University Hospital of Pisa, University of Pisa, Pisa, Italy
Breast Cancer Res Treat 82:1-9. 2003..While loss of p53 checkpoint control is likely to be an important step in the molecular pathogenesis of BRCA1-associated cancers, our data seem to indicate a p53-independent molecular mechanism underlying BRCAx neoplastic transformation...- RNA-based analysis of BRCA1 and BRCA2 gene alterationsFabrizia Bonatti
Section of Genetic Oncology, Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Via Roma, Pisa, Italy
Cancer Genet Cytogenet 170:93-101. 2006..BRCA1 c.IVS17 + 6C>G, BRCA2 c.IVS12-9del4, and BRCA2 IVS1-9del3 represent rare variants, not disrupting normal mRNA processing. The last two BRCA2 genetic variants had not been reported in the Breast Cancer Information Core BIC database... - Markers of cell proliferation, apoptosis, and angiogenesis in thyroid adenomas: a comparative immunohistochemical and genetic investigation of functioning and nonfunctioning nodulesPaolo Viacava
Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa, Italy
Thyroid 17:191-7. 2007.... 
PIK3CA in breast carcinoma: a mutational analysis of sporadic and hereditary casesAngela Michelucci
Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, University Hospital of Pisa, Italy
Diagn Mol Pathol 18:200-5. 2009..The PIK3CA mutation seems to characterize the luminal-type BC, in both sporadic and BRCA2 mutated forms, and is absent in the basal-type BC, in both the sporadic and BRCA1 mutated forms...- Are the clinical and pathological features of differentiated thyroid carcinoma really changed over the last 35 years? Study on 4187 patients from a single Italian institution to answer this questionRossella Elisei
Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
J Clin Endocrinol Metab 95:1516-27. 2010..In the last decades, a marked increased prevalence of differentiated thyroid cancer (DTC) has been observed worldwide. The aim of this study was to evaluate the changing features of DTC referred to our institution between 1969 and 2004... - P53 gene status in patients with advanced serous epithelial ovarian cancer in relation to response to paclitaxel- plus platinum-based chemotherapy and long-term clinical outcomeAngiolo Gadducci
Department of Procreative Medicine, Division of Gynecology and Obstetrics, University of Pisa, Italy
Anticancer Res 26:687-93. 2006.... - Angiogenesis and VEGF expression in pre-invasive lesions of the human breastPaolo Viacava
Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and Pisa University Hospital, Pisa, Italy
J Pathol 204:140-6. 2004..No correlation was found between VEGF expression and the degree and/or type of vascularization... - Torquetenovirus infection and ciliary dysmotility in children with recurrent pneumoniaMassimo Pifferi
Department of Pediatrics, Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa, Pisa, Italy
Pediatr Infect Dis J 27:413-8. 2008.... - Microvessel density in human normal and neoplastic parathyroidsPaolo Viacava
Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Via Roma, 55, 56126 Pisa, Italy
Endocr Pathol 17:175-81. 2006..Therefore, angiogenesis in parathyroid adenomas and carcinomas appears to be an early event, which does not follow a parallel increase in size... - Different expressivity of BRCA1 and BRCA2: analysis of 179 Italian pedigrees with identified mutationPaolo Aretini
Section of Oncogenetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa, Italy
Breast Cancer Res Treat 81:71-9. 2003..Proportion of ovarian cancer was increased in the 5' portion of BRCA1, and presence of prostate or pancreatic cancer in a family was correlated with presence of ovarian cancer in BRCA2... - Genetic alterations in hereditary breast cancerG Cipollini
Section of Onco Genetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and University Hospital of Pisa, Pisa, Italy
Ann Oncol 15:I7-I13. 2004..The presence of founder mutations has practical implications for genetic testing... - Collection, banking and diagnostic archiving of tissuesG Bevilacqua
Divisione di Anatomia Patologica e Diagnostica Molecolare ed Ultrastrutturale, , Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
Pathologica 100:49-54. 2008 - Cyclins of phases G1, S and G2/M are overexpressed in aneuploid mammary carcinomasP Collecchi
Department of Oncology, Division of Pathology, University of Pisa, Pisa, Italy
Cytometry 42:254-60. 2000..Furthermore, overexpression of these proteins is related to the aneuploid and high proliferative activity of human mammary carcinomas... - Cyclin D1 and retinoblastoma susceptibility gene alterations in non-small cell lung cancerA Marchetti
Department of Oncology, University of Pisa, Italy
Int J Cancer 75:187-92. 1998..Abnormalities of cyclin D1 and/or RB at the gene and/or expression level were present in more than 90% of cases, stressing that cyclin D1 and/or RB alterations represent an important step in lung tumorigenesis... - FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutationsA Marchetti
Department of Oncology, University of Pisa, Italy
J Pathol 184:240-6. 1998..In conclusion, these results indicate that FHIT alterations are frequently involved in BAC tumourigenesis and that genetic changes in the p53 and K-ras genes can distinguish between different histotypes of BAC... - Thrombospondins I and II messenger RNA expression in lung carcinoma: relationship with p53 alterations, angiogenic growth factors, and vascular densityG Fontanini
Department of Oncology, University of Pisa, Italy
Clin Cancer Res 5:155-61. 1999.... - Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tractM A Caligo
Department of Oncology, Division of Pathology, Labaratory of Molecular Genetics, University of Pisa, I 56126 Pisa, Italy
Oncol Rep 7:1371-5. 2000..Mutations in the repeated nucleotide stretches within the coding sequences of TGFbetaRII, IGFRII and bax genes were found only in colon tumors with a high unstable phenotype (more than 3 microsatellite loci altered)... - Bcl-2 expression in pancreas development and pancreatic cancer progressionD Campani
Department of Oncology, Division of Pathology, University of Pisa, Via Roma 57, 56126 Pisa, Italy
J Pathol 194:444-50. 2001.... - Insulin-like growth factor II (IGF-II) immunohistochemistry in breast cancer: relationship with the most important morphological and biochemical prognostic parametersC Giani
Department of Endocrinology and Metabolism, University of Pisa, Italy
Int J Biol Markers 17:90-5. 2002..These preliminary results indicate that IGF-II expression in breast cancer is connected with two important regulators of breast cancer growth and differentiation... - Clinicopathological significance of GADD45 gene alterations in human familial breast carcinomaElisa Sensi
Section of Oncogenetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and University Hospital of Pisa, Italy
Breast Cancer Res Treat 87:197-201. 2004..No mutations were found. LOH at GADD45 locus was identified in 19/59 tumours. GADD45 does not appear to be a frequent mutational target in hereditary breast cancer... - Dysregulated PI3K/Akt/PTEN pathway is a marker of a short disease-free survival in node-negative breast carcinomaAlessandra Capodanno
Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Pisa, Italy
Hum Pathol 40:1408-17. 2009.... - Papillary lesions of the breast: a molecular progression?Claudio Di Cristofano
Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and University Hospital of Pisa, Italy
Breast Cancer Res Treat 90:71-6. 2005..LOH at TP53 locus was also analyzed throughout lesions... - Establishment and characterization of 4 new human pancreatic cancer cell lines: evidences of different tumor phenotypesBarbara Chifenti
Division of Surgical, Regional Referral Center for Pancreatic Diseases Treatment, Azienda Ospedaliera Universitaria Pisana, University of Pisa, Pisa, Italy
Pancreas 38:184-96. 2009..Pancreatic cancer still remains a challenge for its biological complexity and lack of effective therapeutic strategies. Establishing new pancreatic cancer cell lines is therefore of paramount importance to clarify its biology... - MMTV-like sequences in human breast cancer: a fluorescent PCR/laser microdissection approachF Zammarchi
Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa and Pisa University Hospital, Italy
J Pathol 209:436-44. 2006..This approach might be successfully used in large molecular studies that aim to investigate the hypothesis of a retroviral aetiology of human breast cancer... - Haplotype analysis of BRCA1 gene reveals a new gene rearrangement: characterization of a 19.9 KBP deletionMariella Tancredi
Section of Oncogenetics, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, Transplants and New Technologies in Medicine, University of Pisa and University Hospital of Pisa, Italy
Eur J Hum Genet 12:775-7. 2004.... - Definition of the microvascular pattern of the normal human adult mammary glandAntonio G Naccarato
Department of Oncology, Division of Surgical, Molecular and Ultrastructural Pathology, University of Pisa, Italy
J Anat 203:599-603. 2003..4 +/- 1.5) in lobules and ducts, respectively. PR expression levels were in the range 10-13% (11.1 +/- 1.6) and 14-17% (15.2 +/- 1.4), respectively. No correlation was found between ER/PR expression and vascularization parameters... - High level of messenger RNA for BRMS1 in primary breast carcinomas is associated with poor prognosisGrazia Lombardi
Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and Pisa University Hospital, Via Roma 57, 56126 Pisa, Italy
Int J Cancer 120:1169-78. 2007.... - Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinomaNiccola Funel
Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Surgical Pathology, Molecular and Ultrastructural Pathology, University of Pisa, Pisa, Italy
Lab Invest 88:773-84. 2008..The use of these ex vivo techniques for molecular analysis of tumors therefore appears to be of some value in implementing the clinical management of PDAC... - A morpho-molecular diagnosis of papillary thyroid carcinoma: BRAF V600E detection as an important tool in preoperative evaluation of fine-needle aspiratesIvo Marchetti
University of Pisa and Pisa University Hospital, Italy
Thyroid 19:837-42. 2009..We also sought to determine if assessing the presence of BRAF gene mutations in preoperative FNA cytology slides would provide diagnostic information for FNA samples with a reading of indeterminate or suspicious thyroid lesions... - Identification of novel alternatively spliced BRCA1-associated RING domain (BARD1) messenger RNAs in human peripheral blood lymphocytes and in sporadic breast cancer tissuesGrazia Lombardi
Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and Pisa University Hospital, Via Roma 57, 56126 Pisa, Italy
Genes Chromosomes Cancer 46:791-5. 2007..However, we were unable to identify either qualitatively or quantitatively tumor-specific expression patterns of the identified BARD1 splicing variants... - HPV testing and Pap test: role for a combined approach in a non-screened populationI Marchetti
Section of Cytopathology, Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa, Pisa University Hospital, Pisa, Italy
Int J Biol Markers 21:149-56. 2006..0%. This study confirms the limitations of screening programs based on Pap test only. Our results suggest, in fact, that adding the HPV test to primary screening could increase the yield of preinvasive cervical lesions... - Reconstructing the genealogy of a BRCA1 founder mutation by phylogenetic analysisF Marroni
Center of Statistical Genetics, University of Pisa, Pisa, Italy
Ann Hum Genet 72:310-8. 2008..The 1499insA mutation shared by the investigated subjects was estimated to be present in an individual living about 30 generations ago (95% CL 22-56), or 750 years (95% CL 550-1,400)... - The NM23 gene maps to human chromosome band 17q22 and shows a restriction fragment length polymorphism with BglIIL Varesco
Institute of Pathological Anatomy and Histology, University of Pisa, Italy
Genes Chromosomes Cancer 4:84-8. 1992..The mapping of NM23-Hl by panels of rodent-human somatic cell hybrids and in situ hybridization showed that the gene is located in human chromosome band 17q22. A two-allele polymorphism with BglII was demonstrated... - Contrast-enhanced MR imaging in patients with BI-RADS 3-5 microcalcificationsA Cilotti
Division of Diagnostic and Interventional Radiology, University of Pisa, and Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
Radiol Med 112:272-86. 2007..The aim of this study was to evaluate the role of magnetic resonance imaging (MRI) in patients with microcalcifications classed as Breast Imaging Reporting and Data Systems (BI-RADS) 3-5... - Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in Italian BRCA1/2 carriersC Pepe
Section of Oncogenetics, Division of Pathology, Department of Oncology, University of Pisa, Via Roma, 57, PI, I 56126 Pisa, Italy
Breast Cancer Res Treat 103:29-36. 2007..The presence of 677T allele confers an increased risk of breast cancer in BRCA1 carriers (P = 0.007) and the presence of 1298C allele confers an increased risk of breast cancer in sporadic cases (P = 0.015)... - The Italian multi-centre project on evaluation of MRI and other imaging modalities in early detection of breast cancer in subjects at high genetic riskF Podo
Istituto Superiore di Sanita, Laboratorio di Biologia Cellulare, Roma, Italy
J Exp Clin Cancer Res 21:115-24. 2002..These preliminary results confirmed that MRI is a very useful tool to screen subjects at high genetic risk for breast carcinoma, not only in pre-, but also in post-menopausal age, with a low probability of false positive cases... - Breast MR imaging screening in eight women proved or suspected to be carriers of BRCA1&2 gene mutationsA Cilotti
Division of Diagnostic and Interventional Radiology, Dept. of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa and Azienda Ospedaliera Pisana, Pisa, Italy
J Exp Clin Cancer Res 21:137-40. 2002..MR imaging proved itself to be a reliable technique in familial breast cancer high risk women... - [Pursuing the future]G Bevilacqua
Pathologica 95:4-8. 2003 - An observational study of surfactant treatment in infants of 23-30 weeks' gestation: comparison of prophylaxis and early rescueG Bevilacqua
Department of Gynecological, Obstetrical and Neonatological Sciences, Section of Child Health and Neonatology, University of Parma, Italy
J Matern Fetal Neonatal Med 14:197-204. 2003..Not surprisingly, infants treated with prophylactic surfactant had a lower rate of RDS than the infants treated by early rescue, even though they did not need less surfactant overall... - Evaluation of widely used models for predicting BRCA1 and BRCA2 mutationsF Marroni
J Med Genet 41:278-85. 2004 - The policy of antenatal corticosteroid administration in Italy vs. other European countriesEv Cosmi
Institute of Gynecology, Perinatology and Child Health, University La Sapienza, Rome, Italy
J Matern Fetal Neonatal Med 16:1-3. 2004..To describe antenatal corticosteroid policies in Italy in comparison with other European countries, as inferred by the published data of the EURAIL Study Group (1999)... - The web survey network of sudden infant death syndrome and apparent life-threatening events in the Emilia-Romagna regionS Parmigiani
Department of Gynecological, Obstetrical and Neonatological Sciences, Section of Child-Welfare and Neonatal Medicine, SIDS Center, Parma, Italy
J Matern Fetal Neonatal Med 16:37-40. 2004..The characteristics of the network that has just started to collect data, as well its future developmental aspects, are discussed... - Neonatal seizures in preterm infants: clinical outcome and relationship with subsequent epilepsyF Pisani
Child Neuropsychiatric Unit, Department of Pediatrics, Section of Child-Welfare and Neonatal Medicine, University of Parma, Parma, Italy
J Matern Fetal Neonatal Med 16:51-3. 2004..CONCLUSIONS: EEG activity was predictive of the developmental outcome and allowed identification of the infants with SE, a condition often related to neonatal epilepsy (71.4%, p<0.05)... - [Guidelines for health surveillance of health care workers exposed to biological risks set up by the Italian Society for Occupational Health and Industrial Hygiene: application in health facilities of the Regional Health Administration--District No. 7, AnA Copertaro
Ufficio del Medico Competente ASUR, Zona Territoriale 7, Ancona Ospedale di Loreto
Med Lav 96:52-62. 2005.... - [Perinatal risk factors for infection in the newborn. Multicenter clinico-epidemiologic investigation]G Bevilacqua
Dipartimento di Scienze Ginecologiche, Ostetriche e di Neonatologia,
Pediatr Med Chir 27:31-8. 2005.... - Breast carcinoma with osteoclast-like giant cells: immunohistochemical and ultrastructural study of a case and review of the literatureP Viacava
Institute of Pathology, University of Pisa, Italy
Tumori 81:135-41. 1995..The patient was alive and well 30 months following the operation. A review of the literature concerning breast carcinoma with OGCs is also presented...