Research Topics
Species | Carlo BertucciSummaryAffiliation: University of Bologna Country: Italy Publications
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Detail Information
Publications
Enantioselective inhibition of the binding of rac-profens to human serum albumin induced by lithocholateC Bertucci
Dipartimento di Scienze Farmaceutiche, Universita di Bologna, 40126 Bologna, Italy
Chirality 13:372-8. 2001....- Inhibition of drug binding to human serum albumin by cholecystographic agentsCarlo Bertucci
Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, I 40126 Bologna, Italy
Farmaco 58:901-8. 2003..Binding parameters were obtained by optical biosensor analysis: K(D) values were 3.6 x 10(-7) and 2.8 x 10(-8) M for IOP and IOPH, respectively... - Optical biosensor analysis in studying herpes simplex virus glycoprotein D binding to target nectin1 receptorCarlo Bertucci
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, Bologna 40126, Italy
J Pharm Biomed Anal 32:697-706. 2003..8 x 10(-7) M) with respect to gD(305t) (K(D), 2.8 x 10(-6) M). The active ligand concentration decreased on time, however the binding properties of the immobilized receptor were maintained over 5 weeks... - Reversible and covalent binding of drugs to human serum albumin: methodological approaches and physiological relevanceCarlo Bertucci
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, Bologna, 40126, Italy
Curr Med Chem 9:1463-81. 2002..The effect of reversible or covalent binding of drugs will also be discussed and examples of physiological relevance reported... - Use of an immobilised human serum albumin HPLC column as a probe of drug-protein interactions: the reversible binding of valproateC Bertucci
Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Italy
J Chromatogr B Analyt Technol Biomed Life Sci 768:147-55. 2002..This antiepilectic drug was proved to affect the binding at site I, II, and bilirubin binding site. The data have physiological relevance because significant inhibition of the binding resulted at clinic concentrations of valproate... - Gas chromatography/mass spectrometric assay of endogenous cellular lipid peroxidation products: quantitative analysis of 9- and 10-hydroxystearic acidsC Bertucci
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
Rapid Commun Mass Spectrom 16:859-64. 2002..In particular the development of an assay for the free 9-hydroxystearic acid methyl ester makes the method a reliable analytical tool for investigations of the role of this metabolite in the mechanisms of tumour cell proliferation... 
Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugsElisabetta Martini
Department of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy
J Med Chem 54:2512-6. 2011..Compounds 4 and 7 and their enantiomers displayed interesting antihyperalgesic activity in two models of neuropathic pain (streptozotocin-induced and oxalilplatin-induced neuropathy) in comparison with pregabalin...- Insight into the kinetic of amyloid beta (1-42) peptide self-aggregation: elucidation of inhibitors' mechanism of actionManuela Bartolini
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
Chembiochem 8:2152-61. 2007.... - Study of donepezil binding to serum albumin by capillary electrophoresis and circular dichroismRoberto Gotti
Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126, Bologna, Italy
Anal Bioanal Chem 377:875-9. 2003..The observed behaviour suggested that donepezil could be considered a ligand with independent binding to sites I and II; although site III is not the highest affinity site, indirect interaction (i.e. cooperative binding) can be assumed... - Species-dependent stereoselective drug binding to albumin: a circular dichroism studyMarco Pistolozzi
Department of Pharmaceutical Sciences, University of Bologna, Italy
Chirality 20:552-8. 2008..Finally, significant differences were observed in the affinity of bilirubin, being highest for BSA, then decreasing for RSA, HSA, and DSA. A more complex conformational equilibrium was observed for bound bilirubin... - Helicity propensity and interaction of synthetic peptides from heptad-repeat domains of herpes simplex virus 1 glycoprotein H: a circular dichroism studyBarbara Sanavio
Department of Pharmaceutical Chemistry, University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy
Biochim Biophys Acta 1774:781-91. 2007..A reliable estimation of the secondary structure was obtained by optimising the experimental conditions to collect CD data down to 180 nm, and by comparing the structure data yielded by different software packages... - Camptothecin and thiocamptothecin: the role of sulfur in shifting the hydrolysis equilibrium towards the closed lactone formMarco Pistolozzi
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
ChemMedChem 6:1706-14. 2011..Our results suggest that, in aqueous solution, more ionic species (anionic and enolic forms) are present for TCPT. This study provides further insights into the effects of oxygen/sulfur replacement in the CPT pyridone ring... - Investigation on the photochemical stability of lercanidipine and its determination in tablets by HPLC-UV and LC-ESI-MS/MSJessica Fiori
Dipartimento di Scienze Farmaceutiche, , Via Belmeloro 6, 40126 Bologna, Italy
J Pharm Biomed Anal 41:176-81. 2006..The developed stability-indicating HPLC method was then applied to the quality control of commercially available lercanidipine formulations (tablets)... - Design, synthesis, and preliminary pharmacological evaluation of new quinoline derivatives as nicotinic ligandsLuca Guandalini
Laboratory of Design, Synthesis and Study of Biologically Active Heterocycles HeteroBioLab, Department of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, I 50019 Sesto Fiorentino, Italy
J Med Chem 50:4993-5002. 2007..5-10.4 A, interact with the alpha4beta2* nicotinic receptor with Ki in the microM range; compound 3c shows preference for the alpha7* subtype... - Reversible human serum albumin binding of lipocrine: a circular dichroism studyCarlo Bertucci
Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy
Chirality 23:827-32. 2011..Almost the same induced CD spectra were obtained for both (R)- and (S)-lipocrine complexed to HSA, suggesting a similar stereochemistry for the bound enantiomers... - Tocainide analogues binding to human serum albumin: a HPLAC and circular dichroism studyMarco Pistolozzi
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
J Pharm Biomed Anal 53:179-85. 2010..Further, a non-cooperative interaction at sites I and II, and an almost independent binding at the bilirubin binding site on HSA were hypothesised on the bases of the competition experiments... - HSA binding of HIV protease inhibitors: a high-performance affinity chromatography studyCarlo Bertucci
Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy
J Sep Sci 32:1625-31. 2009..These results were in good agreement with previous literature reports and provide more details on how PIs are transported in plasma and how they may compete with other drugs in the body... 
Heptad repeat 2 in herpes simplex virus 1 gH interacts with heptad repeat 1 and is critical for virus entry and fusionTatiana Gianni
Department of Experimental Pathology, Section on Microbiology and Virology, University of Bologna, Italy
J Virol 80:2216-24. 2006..Altogether, HR-2 adds to the features typical of class 1 fusion glycoproteins exhibited by HSV-1 gH...- Structural characterization of p53 isoforms due to the polymorphism at codon 72 by mass spectrometry and circular dichroismMarina Naldi
Department of Pharmaceutical Sciences, Via Belmeloro 6, 40126 Bologna, Italy
J Pharm Biomed Anal 53:200-6. 2010..Furthermore, these studies establish a mass spectrometry method to identify the two isoforms that can be useful for future interactome studies and cancer drug discovery... - Rapid screening of small ligand affinity to human serum albumin by an optical biosensorCarlo Bertucci
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, Bologna, Italy
J Pharm Biomed Anal 32:707-14. 2003.... - Binding studies of taxanes to human serum albumin by bioaffinity chromatography and circular dichroismCarlo Bertucci
Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
J Pharm Biomed Anal 42:81-7. 2006..These experiments established a non-cooperative binding mechanism... - Synthesis and resolution of cis-(+/-)-methyl (1R,2S/1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate [(+/-)-PPCC)]: new sigma receptor ligands with neuroprotective effectOrazio Prezzavento
Department of Pharmaceutical Sciences, Medicinal Chemistry Section, University of Catania, Catania, Italy
J Med Chem 53:5881-5. 2010..They exhibited in vivo anti-opioid effects on kappa opioid (KOP) receptor-mediated analgesia. Our findings demonstrate that the enantiomers display mainly sigma(1) agonist activity and that they have neuroprotective effects... - Amyloid β-peptide 25-35 self-assembly and its inhibition: a model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease process and treatmentMarina Naldi
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
ACS Chem Neurosci 3:952-62. 2012.... - Structural characterization of recombinant therapeutic proteins by circular dichroismCarlo Bertucci
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
Curr Pharm Biotechnol 12:1508-16. 2011.... - Determination of the chiral and achiral related substances of methotrexate by cyclodextrin-modified micellar electrokinetic chromatographyRoberto Gotti
Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Bologna, Italy
Electrophoresis 25:2830-7. 2004.... - Synthesis and HSA binding characterisation of the water soluble 7-succinylpaclitaxelArturo Battaglia
Istituto ISOF C N R via Gobetti, 101 40129, Bologna, Italy
Eur J Med Chem 38:383-9. 2003..5x10(4) M(-1)), while no significant interactions were evidenced with selective markers for the most characterised binding sites on the carrier, suggesting a non-selective binding to low affinity binding sites... - Circular dichroism in drug discovery and development: an abridged reviewCarlo Bertucci
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
Anal Bioanal Chem 398:155-66. 2010.... - Optical biosensors as a tool for early determination of absorption and distribution parameters of lead candidates and drugsCarlo Bertucci
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, I 40126 Bologna, Italy
Comb Chem High Throughput Screen 10:433-40. 2007.... - Histone deacetylase 1: a target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancerNatalia Calonghi
Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
J Lipid Res 46:1596-603. 2005..Consistent with the experimental data, we find that 9-HSA can bind to the active site of the protein, showing that the inhibition of the enzyme can be explained at the molecular level by the ligand-protein interaction... - Advantages of electronic circular dichroism detection for the stereochemical analysis and characterization of drugs and natural products by liquid chromatographyCarlo Bertucci
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
J Chromatogr A 1269:69-81. 2012.... - The role of polyamine architecture on the pharmacological activity of open lactone camptothecin-polyamine conjugatesCristian Samorì
Istituto CNR per la Sintesi Organica e Fotoreattivita ISOF, Area della Ricerca di Bologna, Bologna, Italy
Bioconjug Chem 19:2270-9. 2008..The architecture of the polyamine moiety is important for antiproliferative activity, and a balance between the hydrophilic and lipophilic properties of the polyamine is critical for CPT potency... - Assignment of the absolute configuration at the sulfur atom of thioridazine metabolites by the analysis of their chiroptical properties: the case of thioridazine 2-sulfoxideCarlo Bertucci
Dipartimento Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
J Pharm Biomed Anal 52:796-801. 2010..The developed method should be useful for a reliable correlation between stereochemistry and activity and/or toxicity... - Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approachAndrea Cavalli
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro, 6, I-40126 Bologna, Italy
J Med Chem 48:7282-9. 2005..A satisfactory agreement between experimental and predicted data allowed us to assert that a properly built "enantioselective CoMFA model" might constitute a useful tool for addressing enantioselective ligands design... - Conformational flexibility and absolute stereochemistry of (3R)-3-hydroxy-4-aryl-β-lactams investigated by chiroptical properties and TD-DFT calculationsDaniele Tedesco
Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy
Chirality 24:741-50. 2012.... - Stereochemical characterization of fluorinated 2-(phenanthren-1-yl)propionic acids by enantioselective high performance liquid chromatography analysis and electronic circular dichroism detectionCarlo Bertucci
Department of Pharmaceutical Sciences, University of Bologna, Italy
J Chromatogr A 1232:128-33. 2012.... - Substitution in the murine nectin1 receptor of a single conserved amino acid at a position distal from the herpes simplex virus gD binding site confers high-affinity binding to gDLaura Menotti
Department of Experimental Pathology, Section on Microbiology and Virology, University of Bologna, Bologna, Italy
J Virol 76:5463-71. 2002..The results support the notion that the overall structure of V nectin1 plays a pivotal role in its ability to bind HSV gD... - Characterisation of the conjugate of the (6-maleimidocaproyl)hydrazone derivative of doxorubicin with lactosaminated human albumin by 13C NMR spectroscopyCarla Boga
Department of Organic Chemistry A Mangini, University of Bologna, Italy
Eur J Pharm Sci 38:262-9. 2009..When hydrolysed in an acidic medium to cleave the hydrazone bond, type I conjugate released only DOXO, whereas type II conjugate also released a derivative of the drug... - The rapid and direct determination of ATPase activity by ion exchange chromatography and the application to the activity of heat shock protein-90Manuela Bartolini
Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
J Pharm Biomed Anal 73:77-81. 2013.... - Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agentElisabetta Martini
Dipartimento di Scienze Farmaceutiche, , Via Ugo Schiff 6, 50019 Sesto Fiorentino (FI, Italy
Med Chem 1:473-80. 2005..On the contrary, (R)-(+) and (S)-(-)-(2) showed the same amnesic potency when tested in the passive-avoidance test. These findings may be useful to clarify the mechanism of action of these substances... - beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studiesManuela Bartolini
Dipartimento di Scienze Farmaceutiche, , Via Belmeloro 6, 40126 Bologna, Italy
Biochem Pharmacol 65:407-16. 2003..At 100 microM propidium, decamethonium, donepezil and physostigmine were found to inhibit the HuAChE-induced Abeta aggregation by 82, 25, 22 and 30%, respectively... - 4-hydroxy-2,3 trans-nonenal nuclear concentration inversely correlates with the growth rate of T leukemia cellsNatalia Calonghi
Department of Biochemistry G. Moruzzi, University of Bologna, Bologna, Italy
Ital J Biochem 53:28-33. 2004..The cells arrested in G1 show a content of 4-hydroxy-2,3 trans-nonenal significantly increased with respect to control ones... - Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterolFarideh Beigi
Laboratory of Clinical Investigation, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
Chirality 18:822-7. 2006..Further evaluation of R-F will determine if it has enhanced selectivity and specificity for beta2-AR/G(s) activation and if it can be used in the treatment of congestive heart failure... - Drug binding to human serum albumin: abridged review of results obtained with high-performance liquid chromatography and circular dichroismGiorgio A Ascoli
Krasnow Institute for Advanced Study and Psychology Department, George Mason University, Fairfax, VA, USA
Chirality 18:667-79. 2006.... - Stereoselective metabolism of metoprolol: enantioselectivity of alpha-hydroxymetoprolol in plasma and urinePaula Macedo Cerqueira
, , , SP, Brazil
Chirality 15:542-9. 2003..S)-metoprolol was slightly more alpha-hydroxylated than its antipode (AUC(0-24) (2S/2R) = 1.19), suggesting that this pathway is not responsible for plasma accumulation of this enantiomer in humans... - Early absorption and distribution analysis of antitumor and anti-AIDS drugs: lipid membrane and plasma protein interactionsSamanta Cimitan
Department of Biochemistry, Uppsala University, Box 576, SE-751 23 Uppsala, Sweden
J Med Chem 48:3536-46. 2005..The sites appear to differ in accessibility and recognition characteristics rather than in their capacities to form strong complexes with drugs... - Reliable HPLC method for therapeutic drug monitoring of frequently prescribed tricyclic and nontricyclic antidepressantsWilson Roberto Malfará
Department of Psychiatry and Psychology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida do Cafe s n, Monte Alegre, CEP 14040 903 Ribeirao Preto, SP, Brazil
J Pharm Biomed Anal 44:955-62. 2007..The method has been successfully applied to the analysis of real samples, for the drug monitoring of ten frequently prescribed tricyclic and non-tricyclic antidepressant drugs... - Synthesis and biological evaluation of 2'-methyl taxoids derived from baccatin III and 14beta-OH-baccatin III 1,14-carbonateArturo Battaglia
Istituto CNR per la Sintesi Organica e Fotoreattività I S O F, Via Gobetti 101, 40129 Bologna, Italy
J Med Chem 46:4822-5. 2003..Additional experiments were performed on MCF-7 human breast cancer cell line and MCF7-R resistant to doxorubicin. In several cases these taxoids were more active than paclitaxel showing subnanomolar IC(50) values... - Eleventh meeting on Recent Developments in Pharmaceutical Analysis (RDPA 2005). Rimini (Italy), September 25-28, 2005Carlo Bertucci
J Sep Sci 29:182. 2006