Carlo Bertucci

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Enantioselective inhibition of the binding of rac-profens to human serum albumin induced by lithocholate
    C Bertucci
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, 40126 Bologna, Italy
    Chirality 13:372-8. 2001
  2. ncbi Optical biosensor analysis in studying herpes simplex virus glycoprotein D binding to target nectin1 receptor
    Carlo Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, Bologna 40126, Italy
    J Pharm Biomed Anal 32:697-706. 2003
  3. ncbi Inhibition of drug binding to human serum albumin by cholecystographic agents
    Carlo Bertucci
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, I 40126 Bologna, Italy
    Farmaco 58:901-8. 2003
  4. ncbi Reversible and covalent binding of drugs to human serum albumin: methodological approaches and physiological relevance
    Carlo Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, Bologna, 40126, Italy
    Curr Med Chem 9:1463-81. 2002
  5. ncbi Gas chromatography/mass spectrometric assay of endogenous cellular lipid peroxidation products: quantitative analysis of 9- and 10-hydroxystearic acids
    C Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Rapid Commun Mass Spectrom 16:859-64. 2002
  6. ncbi Use of an immobilised human serum albumin HPLC column as a probe of drug-protein interactions: the reversible binding of valproate
    C Bertucci
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 768:147-55. 2002
  7. doi Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs
    Elisabetta Martini
    Department of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy
    J Med Chem 54:2512-6. 2011
  8. ncbi Helicity propensity and interaction of synthetic peptides from heptad-repeat domains of herpes simplex virus 1 glycoprotein H: a circular dichroism study
    Barbara Sanavio
    Department of Pharmaceutical Chemistry, University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy
    Biochim Biophys Acta 1774:781-91. 2007
  9. ncbi Insight into the kinetic of amyloid beta (1-42) peptide self-aggregation: elucidation of inhibitors' mechanism of action
    Manuela Bartolini
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Chembiochem 8:2152-61. 2007
  10. doi Species-dependent stereoselective drug binding to albumin: a circular dichroism study
    Marco Pistolozzi
    Department of Pharmaceutical Sciences, University of Bologna, Italy
    Chirality 20:552-8. 2008

Collaborators

Detail Information

Publications51

  1. ncbi Enantioselective inhibition of the binding of rac-profens to human serum albumin induced by lithocholate
    C Bertucci
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, 40126 Bologna, Italy
    Chirality 13:372-8. 2001
    ....
  2. ncbi Optical biosensor analysis in studying herpes simplex virus glycoprotein D binding to target nectin1 receptor
    Carlo Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, Bologna 40126, Italy
    J Pharm Biomed Anal 32:697-706. 2003
    ..8 x 10(-7) M) with respect to gD(305t) (K(D), 2.8 x 10(-6) M). The active ligand concentration decreased on time, however the binding properties of the immobilized receptor were maintained over 5 weeks...
  3. ncbi Inhibition of drug binding to human serum albumin by cholecystographic agents
    Carlo Bertucci
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, I 40126 Bologna, Italy
    Farmaco 58:901-8. 2003
    ..Binding parameters were obtained by optical biosensor analysis: K(D) values were 3.6 x 10(-7) and 2.8 x 10(-8) M for IOP and IOPH, respectively...
  4. ncbi Reversible and covalent binding of drugs to human serum albumin: methodological approaches and physiological relevance
    Carlo Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, Bologna, 40126, Italy
    Curr Med Chem 9:1463-81. 2002
    ..The effect of reversible or covalent binding of drugs will also be discussed and examples of physiological relevance reported...
  5. ncbi Gas chromatography/mass spectrometric assay of endogenous cellular lipid peroxidation products: quantitative analysis of 9- and 10-hydroxystearic acids
    C Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Rapid Commun Mass Spectrom 16:859-64. 2002
    ..In particular the development of an assay for the free 9-hydroxystearic acid methyl ester makes the method a reliable analytical tool for investigations of the role of this metabolite in the mechanisms of tumour cell proliferation...
  6. ncbi Use of an immobilised human serum albumin HPLC column as a probe of drug-protein interactions: the reversible binding of valproate
    C Bertucci
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 768:147-55. 2002
    ..This antiepilectic drug was proved to affect the binding at site I, II, and bilirubin binding site. The data have physiological relevance because significant inhibition of the binding resulted at clinic concentrations of valproate...
  7. doi Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs
    Elisabetta Martini
    Department of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Italy
    J Med Chem 54:2512-6. 2011
    ..Compounds 4 and 7 and their enantiomers displayed interesting antihyperalgesic activity in two models of neuropathic pain (streptozotocin-induced and oxalilplatin-induced neuropathy) in comparison with pregabalin...
  8. ncbi Helicity propensity and interaction of synthetic peptides from heptad-repeat domains of herpes simplex virus 1 glycoprotein H: a circular dichroism study
    Barbara Sanavio
    Department of Pharmaceutical Chemistry, University of Bologna, Via Belmeloro 6, 40126, Bologna, Italy
    Biochim Biophys Acta 1774:781-91. 2007
    ..A reliable estimation of the secondary structure was obtained by optimising the experimental conditions to collect CD data down to 180 nm, and by comparing the structure data yielded by different software packages...
  9. ncbi Insight into the kinetic of amyloid beta (1-42) peptide self-aggregation: elucidation of inhibitors' mechanism of action
    Manuela Bartolini
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Chembiochem 8:2152-61. 2007
    ....
  10. doi Species-dependent stereoselective drug binding to albumin: a circular dichroism study
    Marco Pistolozzi
    Department of Pharmaceutical Sciences, University of Bologna, Italy
    Chirality 20:552-8. 2008
    ..Finally, significant differences were observed in the affinity of bilirubin, being highest for BSA, then decreasing for RSA, HSA, and DSA. A more complex conformational equilibrium was observed for bound bilirubin...
  11. ncbi Study of donepezil binding to serum albumin by capillary electrophoresis and circular dichroism
    Roberto Gotti
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126, Bologna, Italy
    Anal Bioanal Chem 377:875-9. 2003
    ..The observed behaviour suggested that donepezil could be considered a ligand with independent binding to sites I and II; although site III is not the highest affinity site, indirect interaction (i.e. cooperative binding) can be assumed...
  12. pmc Amyloid β-peptide 25-35 self-assembly and its inhibition: a model undecapeptide system to gain atomistic and secondary structure details of the Alzheimer's disease process and treatment
    Marina Naldi
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    ACS Chem Neurosci 3:952-62. 2012
    ....
  13. doi Camptothecin and thiocamptothecin: the role of sulfur in shifting the hydrolysis equilibrium towards the closed lactone form
    Marco Pistolozzi
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    ChemMedChem 6:1706-14. 2011
    ..Our results suggest that, in aqueous solution, more ionic species (anionic and enolic forms) are present for TCPT. This study provides further insights into the effects of oxygen/sulfur replacement in the CPT pyridone ring...
  14. ncbi Design, synthesis, and preliminary pharmacological evaluation of new quinoline derivatives as nicotinic ligands
    Luca Guandalini
    Laboratory of Design, Synthesis and Study of Biologically Active Heterocycles HeteroBioLab, Department of Pharmaceutical Sciences, University of Florence, Via Ugo Schiff 6, I 50019 Sesto Fiorentino, Italy
    J Med Chem 50:4993-5002. 2007
    ..5-10.4 A, interact with the alpha4beta2* nicotinic receptor with Ki in the microM range; compound 3c shows preference for the alpha7* subtype...
  15. ncbi Investigation on the photochemical stability of lercanidipine and its determination in tablets by HPLC-UV and LC-ESI-MS/MS
    Jessica Fiori
    Dipartimento di Scienze Farmaceutiche, Alma Mater Studiorum Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Pharm Biomed Anal 41:176-81. 2006
    ..The developed stability-indicating HPLC method was then applied to the quality control of commercially available lercanidipine formulations (tablets)...
  16. doi Reversible human serum albumin binding of lipocrine: a circular dichroism study
    Carlo Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy
    Chirality 23:827-32. 2011
    ..Almost the same induced CD spectra were obtained for both (R)- and (S)-lipocrine complexed to HSA, suggesting a similar stereochemistry for the bound enantiomers...
  17. pmc Heptad repeat 2 in herpes simplex virus 1 gH interacts with heptad repeat 1 and is critical for virus entry and fusion
    Tatiana Gianni
    Department of Experimental Pathology, Section on Microbiology and Virology, University of Bologna, Italy
    J Virol 80:2216-24. 2006
    ..Altogether, HR-2 adds to the features typical of class 1 fusion glycoproteins exhibited by HSV-1 gH...
  18. doi HSA binding of HIV protease inhibitors: a high-performance affinity chromatography study
    Carlo Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy
    J Sep Sci 32:1625-31. 2009
    ..These results were in good agreement with previous literature reports and provide more details on how PIs are transported in plasma and how they may compete with other drugs in the body...
  19. doi Tocainide analogues binding to human serum albumin: a HPLAC and circular dichroism study
    Marco Pistolozzi
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Pharm Biomed Anal 53:179-85. 2010
    ..Further, a non-cooperative interaction at sites I and II, and an almost independent binding at the bilirubin binding site on HSA were hypothesised on the bases of the competition experiments...
  20. doi Structural characterization of p53 isoforms due to the polymorphism at codon 72 by mass spectrometry and circular dichroism
    Marina Naldi
    Department of Pharmaceutical Sciences, Via Belmeloro 6, 40126 Bologna, Italy
    J Pharm Biomed Anal 53:200-6. 2010
    ..Furthermore, these studies establish a mass spectrometry method to identify the two isoforms that can be useful for future interactome studies and cancer drug discovery...
  21. ncbi Rapid screening of small ligand affinity to human serum albumin by an optical biosensor
    Carlo Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, Bologna, Italy
    J Pharm Biomed Anal 32:707-14. 2003
    ....
  22. ncbi Binding studies of taxanes to human serum albumin by bioaffinity chromatography and circular dichroism
    Carlo Bertucci
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Pharm Biomed Anal 42:81-7. 2006
    ..These experiments established a non-cooperative binding mechanism...
  23. doi Synthesis and resolution of cis-(+/-)-methyl (1R,2S/1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate [(+/-)-PPCC)]: new sigma receptor ligands with neuroprotective effect
    Orazio Prezzavento
    Department of Pharmaceutical Sciences, Medicinal Chemistry Section, University of Catania, Catania, Italy
    J Med Chem 53:5881-5. 2010
    ..They exhibited in vivo anti-opioid effects on kappa opioid (KOP) receptor-mediated analgesia. Our findings demonstrate that the enantiomers display mainly sigma(1) agonist activity and that they have neuroprotective effects...
  24. doi Determination of dextromethorphan and levomethorphan in seized heroin samples by enantioselective HPLC and electronic CD
    Daniele Tedesco
    Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Pharm Biomed Anal 81:76-9. 2013
    ....
  25. ncbi Assignment of the absolute configuration at the sulfur atom of thioridazine metabolites by the analysis of their chiroptical properties: the case of thioridazine 2-sulfoxide
    Carlo Bertucci
    Dipartimento Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Pharm Biomed Anal 52:796-801. 2010
    ..The developed method should be useful for a reliable correlation between stereochemistry and activity and/or toxicity...
  26. pmc The rapid and direct determination of ATPase activity by ion exchange chromatography and the application to the activity of heat shock protein-90
    Manuela Bartolini
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Pharm Biomed Anal 73:77-81. 2013
    ....
  27. ncbi Conformational flexibility and absolute stereochemistry of (3R)-3-hydroxy-4-aryl-β-lactams investigated by chiroptical properties and TD-DFT calculations
    Daniele Tedesco
    Department of Pharmaceutical Sciences, University of Bologna, Bologna, Italy
    Chirality 24:741-50. 2012
    ....
  28. ncbi Structural characterization of recombinant therapeutic proteins by circular dichroism
    Carlo Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Curr Pharm Biotechnol 12:1508-16. 2011
    ....
  29. doi Circular dichroism in drug discovery and development: an abridged review
    Carlo Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Anal Bioanal Chem 398:155-66. 2010
    ....
  30. ncbi Optical biosensors as a tool for early determination of absorption and distribution parameters of lead candidates and drugs
    Carlo Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, I 40126 Bologna, Italy
    Comb Chem High Throughput Screen 10:433-40. 2007
    ....
  31. ncbi Determination of the chiral and achiral related substances of methotrexate by cyclodextrin-modified micellar electrokinetic chromatography
    Roberto Gotti
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Bologna, Italy
    Electrophoresis 25:2830-7. 2004
    ....
  32. ncbi Histone deacetylase 1: a target of 9-hydroxystearic acid in the inhibition of cell growth in human colon cancer
    Natalia Calonghi
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    J Lipid Res 46:1596-603. 2005
    ..Consistent with the experimental data, we find that 9-HSA can bind to the active site of the protein, showing that the inhibition of the enzyme can be explained at the molecular level by the ligand-protein interaction...
  33. ncbi Synthesis and HSA binding characterisation of the water soluble 7-succinylpaclitaxel
    Arturo Battaglia
    Istituto ISOF C N R via Gobetti, 101 40129, Bologna, Italy
    Eur J Med Chem 38:383-9. 2003
    ..5x10(4) M(-1)), while no significant interactions were evidenced with selective markers for the most characterised binding sites on the carrier, suggesting a non-selective binding to low affinity binding sites...
  34. doi Advantages of electronic circular dichroism detection for the stereochemical analysis and characterization of drugs and natural products by liquid chromatography
    Carlo Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Chromatogr A 1269:69-81. 2012
    ....
  35. doi The role of polyamine architecture on the pharmacological activity of open lactone camptothecin-polyamine conjugates
    Cristian Samorì
    Istituto CNR per la Sintesi Organica e Fotoreattivita ISOF, Area della Ricerca di Bologna, Bologna, Italy
    Bioconjug Chem 19:2270-9. 2008
    ..The architecture of the polyamine moiety is important for antiproliferative activity, and a balance between the hydrophilic and lipophilic properties of the polyamine is critical for CPT potency...
  36. ncbi Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach
    Andrea Cavalli
    Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro, 6, I 40126 Bologna, Italy
    J Med Chem 48:7282-9. 2005
    ..A satisfactory agreement between experimental and predicted data allowed us to assert that a properly built "enantioselective CoMFA model" might constitute a useful tool for addressing enantioselective ligands design...
  37. ncbi Stereochemical and conformational study on fenoterol by ECD spectroscopy and TD-DFT calculations
    Daniele Tedesco
    Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Pharm Biomed Anal 91:92-6. 2014
    ....
  38. doi Stereochemical characterization of fluorinated 2-(phenanthren-1-yl)propionic acids by enantioselective high performance liquid chromatography analysis and electronic circular dichroism detection
    Carlo Bertucci
    Department of Pharmaceutical Sciences, University of Bologna, Italy
    J Chromatogr A 1232:128-33. 2012
    ....
  39. pmc Substitution in the murine nectin1 receptor of a single conserved amino acid at a position distal from the herpes simplex virus gD binding site confers high-affinity binding to gD
    Laura Menotti
    Department of Experimental Pathology, Section on Microbiology and Virology, University of Bologna, Bologna, Italy
    J Virol 76:5463-71. 2002
    ..The results support the notion that the overall structure of V nectin1 plays a pivotal role in its ability to bind HSV gD...
  40. doi Characterisation of the conjugate of the (6-maleimidocaproyl)hydrazone derivative of doxorubicin with lactosaminated human albumin by 13C NMR spectroscopy
    Carla Boga
    Department of Organic Chemistry A Mangini, University of Bologna, Italy
    Eur J Pharm Sci 38:262-9. 2009
    ..When hydrolysed in an acidic medium to cleave the hydrazone bond, type I conjugate released only DOXO, whereas type II conjugate also released a derivative of the drug...
  41. ncbi Optical biosensor analysis in studying new synthesized bicalutamide analogs binding to androgen receptor
    Cecilia Fortugno
    Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy
    J Pharm Biomed Anal 95:151-7. 2014
    ....
  42. ncbi Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent
    Elisabetta Martini
    Dipartimento di Scienze Farmaceutiche, Universita di Firenze, Via Ugo Schiff 6, 50019 Sesto Fiorentino FI, Italy
    Med Chem 1:473-80. 2005
    ..On the contrary, (R)-(+) and (S)-(-)-(2) showed the same amnesic potency when tested in the passive-avoidance test. These findings may be useful to clarify the mechanism of action of these substances...
  43. ncbi beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies
    Manuela Bartolini
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    Biochem Pharmacol 65:407-16. 2003
    ..At 100 microM propidium, decamethonium, donepezil and physostigmine were found to inhibit the HuAChE-induced Abeta aggregation by 82, 25, 22 and 30%, respectively...
  44. ncbi 4-hydroxy-2,3 trans-nonenal nuclear concentration inversely correlates with the growth rate of T leukemia cells
    Natalia Calonghi
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    Ital J Biochem 53:28-33. 2004
    ..The cells arrested in G1 show a content of 4-hydroxy-2,3 trans-nonenal significantly increased with respect to control ones...
  45. ncbi Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol
    Farideh Beigi
    Laboratory of Clinical Investigation, National Institute on Aging Intramural Research Program, Baltimore, Maryland, USA
    Chirality 18:822-7. 2006
    ..It has two chiral centers and is marketed as a racemic mixture of R,R'- and S,S'-fenoterol (R-F and S-F). Here we report the separation of the R-F and S-F enantiomers and the evaluation of their binding to and activation of the beta2-AR...
  46. ncbi Drug binding to human serum albumin: abridged review of results obtained with high-performance liquid chromatography and circular dichroism
    Giorgio A Ascoli
    Krasnow Institute for Advanced Study and Psychology Department, George Mason University, Fairfax, VA, USA
    Chirality 18:667-79. 2006
    ....
  47. ncbi Stereoselective metabolism of metoprolol: enantioselectivity of alpha-hydroxymetoprolol in plasma and urine
    Paula Macedo Cerqueira
    Faculdade de Ciencias Farmaceuticas, Universidade de Sao Paulo, Sao Paulo, SP, Brazil
    Chirality 15:542-9. 2003
    ..S)-metoprolol was slightly more alpha-hydroxylated than its antipode (AUC(0-24) (2S/2R) = 1.19), suggesting that this pathway is not responsible for plasma accumulation of this enantiomer in humans...
  48. ncbi Early absorption and distribution analysis of antitumor and anti-AIDS drugs: lipid membrane and plasma protein interactions
    Samanta Cimitan
    Department of Biochemistry, Uppsala University, Box 576, SE 751 23 Uppsala, Sweden
    J Med Chem 48:3536-46. 2005
    ..The sites appear to differ in accessibility and recognition characteristics rather than in their capacities to form strong complexes with drugs...
  49. ncbi Eleventh meeting on Recent Developments in Pharmaceutical Analysis (RDPA 2005). Rimini (Italy), September 25-28, 2005
    Carlo Bertucci
    J Sep Sci 29:182. 2006
  50. ncbi Synthesis and biological evaluation of 2'-methyl taxoids derived from baccatin III and 14beta-OH-baccatin III 1,14-carbonate
    Arturo Battaglia
    Istituto CNR per la Sintesi Organica e Fotoreattività I S O F, Via Gobetti 101, 40129 Bologna, Italy
    J Med Chem 46:4822-5. 2003
    ..Additional experiments were performed on MCF-7 human breast cancer cell line and MCF7-R resistant to doxorubicin. In several cases these taxoids were more active than paclitaxel showing subnanomolar IC(50) values...
  51. ncbi Reliable HPLC method for therapeutic drug monitoring of frequently prescribed tricyclic and nontricyclic antidepressants
    Wilson Roberto Malfará
    Department of Psychiatry and Psychology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida do Cafe s n, Monte Alegre, CEP 14040 903 Ribeirao Preto, SP, Brazil
    J Pharm Biomed Anal 44:955-62. 2007
    ..The method has been successfully applied to the analysis of real samples, for the drug monitoring of ten frequently prescribed tricyclic and non-tricyclic antidepressant drugs...