Research Topics
Genomes and Genes | Alessandro BertolinoSummaryAffiliation: University of Bari Country: Italy Publications
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Detail Information
Publications
Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brainAlessandro Bertolino
Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
J Neurosci 26:3918-22. 2006..These results demonstrate additive genetic effects of genes regulating dopamine signaling on specific neuronal networks subserving working memory...- Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performanceAlessandro Bertolino
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
Psychiatry Res 147:221-6. 2006..We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex... - Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality styleAlessandro Bertolino
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
Biol Psychiatry 57:1517-25. 2005..The objective of this study was to explore the relevance of personality style for variability of amygdala response... - Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophreniaAlessandro Bertolino
Dipartimento di Scienze Neurologiche e Psichiatriche, Universita degli Studi di Bari, Piazza Giulio Cesare 9, 70124, Bari, Italy
Am J Psychiatry 161:1798-805. 2004.... - Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorderAlessandro Bertolino
Department of Psychiatry and Neurological Sciences, University of Bari, Italy
Am J Psychiatry 160:483-9. 2003..In addition, they assessed the relationship between N-acetylaspartate levels and working memory deficits... 
Epistasis between dopamine regulating genes identifies a nonlinear response of the human hippocampus during memory tasksAlessandro Bertolino
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
Biol Psychiatry 64:226-34. 2008..Here, we investigated the effect of genetic variation of dopamine inactivation via catechol-O-methyltransferase (COMT) and the dopamine transporter (DAT) on hippocampal activity in healthy humans during different memory conditions...- Nonlinear response of the anterior cingulate and prefrontal cortex in schizophrenia as a function of variable attentional controlGiuseppe Blasi
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari 70124, Italy
Cereb Cortex 20:837-45. 2010.... 
Treatment with olanzapine is associated with modulation of the default mode network in patients with SchizophreniaFabio Sambataro
Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
Neuropsychopharmacology 35:904-12. 2010..These results suggest that treatment with olanzapine is associated with the modulation of DMN connectivity in schizophrenia. In addition, our findings suggest critical functional differences in the regions of DMN...- Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humansGiuseppe Blasi
Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
J Neurosci 29:14812-9. 2009..These results suggest that genetically determined D(2) signaling may explain part of personality traits related to emotion processing and individual variability in specific brain responses to emotionally relevant inputs... - Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotypeAlessandro Bertolino
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
Biol Psychiatry 60:1250-8. 2006..This network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal cortex (VLPFC). Studies in animals have suggested that the relationship between these brain regions is strongly modulated by dopamine... - Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humansAlessandro Bertolino
Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
J Neurosci 29:1224-34. 2009..Together, our results demonstrate that the interaction between genetic variants in DRD(2) and DAT critically modulates the nonlinear relationship between dopamine and neuronal activity during memory processing... - Activity in medial prefrontal cortex during cognitive evaluation of threatening stimuli as a function of personality styleValeria Rubino
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
Brain Res Bull 74:250-7. 2007..These findings are consistent with the contention that cognitive evaluation and salience of emotional stimuli are associated with different personality styles... - Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encodingAnnabella Di Giorgio
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
Eur J Neurosci 28:2129-36. 2008..Moreover, they support the hypothesis that genetic variation in DISC1 may affect the risk for schizophrenia by modifying hippocampal gray matter and function... - D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humansLeonardo Fazio
Department of Neurological and Psychiatric Sciences, University of Bari Aldo Moro, Bari, Italy
Neuroimage 54:2915-21. 2011.... - Hippocampal neurochemical pathology in patients at first episode of affective psychosis: a proton magnetic resonance spectroscopic imaging studyGiuseppe Blasi
Psychiatric Neuroscience Group, Department of Psychiatric and Neurological Sciences, University of Bari, Piazza Giulio Cesare, 9, 70124, Bari, Italy
Psychiatry Res 131:95-105. 2004..Since these data were obtained in patients at first episode, they cannot be explained by chronicity of illness or pharmacological treatment... - Changes in prefrontal and amygdala activity during olanzapine treatment in schizophreniaGiuseppe Blasi
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
Psychiatry Res 173:31-8. 2009..These results suggest that longitudinal treatment with olanzapine may be associated with specific changes in activity of the amygdala and prefrontal cortex during emotional processing in schizophrenia... - Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performanceAlessandro Bertolino
Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
PLoS ONE 5:e9348. 2010..However, the effect of functional genetic variation of DRD2 on striatal dopamine D2 signaling and on its correlation with prefrontal activity during working memory in humans is not known... - Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophreniaAlessandro Bertolino
Department of Neurology and Psychiatry, University of Bari, Bari, Italy
Brain 132:417-25. 2009..Our results indicate that the three functional DRD2 variants modulate schizophrenia phenotypes possibly by modifying D2S/D2L ratios in the context of different total D2 density... - Stress-related methylation of the catechol-O-methyltransferase Val 158 allele predicts human prefrontal cognition and activityGianluca Ursini
Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University Aldo Moro, 71024 Bari, Italy
J Neurosci 31:6692-8. 2011..Moreover, these results demonstrate how stress-related DNA methylation of specific functional alleles impacts directly on human brain physiology beyond sequence variation... - DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophreniaGiuseppe Blasi
Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University Aldo Moro, 70124 Bari, Italy
Proc Natl Acad Sci U S A 108:1158-63. 2011..Our results also lend support to further investigation of this downstream molecular pathway in the etiology and treatment of this disorder... - Preferential amygdala reactivity to the negative assessment of neutral facesGiuseppe Blasi
Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
Biol Psychiatry 66:847-53. 2009..We explored human amygdala function during explicit behavioral decision making about discrete emotional facial expressions that can represent socially unambiguous and ambiguous cues... - Functional lateralization of the sensorimotor cortex in patients with schizophrenia: effects of treatment with olanzapineAlessandro Bertolino
Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
Biol Psychiatry 56:190-7. 2004.... - Preferential responses in amygdala and insula during presentation of facial contempt and disgustFabio Sambataro
Department of Psychiatry, University of Bari, Piazza Giulio Cesare, 9, 70124 Bari, Italy
Eur J Neurosci 24:2355-62. 2006..Our findings suggest preferential involvement of different neural substrates in the processing of facial emotional expressions of contempt and disgust... - Cortical gray matter changes in primary blepharospasm: a voxel-based morphometry studyDavide Martino
Neurological Section, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
Mov Disord 26:1907-12. 2011..Gray matter changes in the primary sensory cortex may represent a common trait of primary dystonias, including blepharospasm... - Imaging genomics and response to treatment with antipsychotics in schizophreniaGiuseppe Blasi
Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy 70125
NeuroRx 3:117-30. 2006..Preliminary evidence with potential susceptilibity genes such as COMT, DISC1, and GRM3 support these assumptions... - Reduced N-acetylaspartate in prefrontal cortex of adult rats with neonatal hippocampal damageAlessandro Bertolino
Clinical Brain Disorders Branch, Intramural Research Programs, National Institute of Mental Health, NIH, 10 Center Drive Room 4S235 MSC 1379, Bethesda, MD 20892, USA
Cereb Cortex 12:983-90. 2002.... - The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal functionMichael F Egan
Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
Cell 112:257-69. 2003..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF... - Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophreniaJoseph H Callicott
Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20982 1389, USA
Am J Psychiatry 160:709-19. 2003..Earlier family studies have suggested that deficits in executive cognition and working memory may be related to genetic susceptibility for schizophrenia, but the biological basis for this behavioral phenotype has not been identified... - Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imagingAlessandro Bertolino
Clinical Brain Disorders Branch, Intramural Research Programs, National Institutes of Health, Bethesda, Maryland 20892, USA
Biol Psychiatry 53:906-13. 2003..As suggested by other studies, neuronal pathology in the hippocampus may be involved in the pathophysiology of bipolar disorder and in susceptibility to psychosis... - Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophreniaMichael F Egan
Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 101:12604-9. 2004..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia... - Effect of catechol-O-methyltransferase val158met genotype on attentional controlGiuseppe Blasi
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
J Neurosci 25:5038-45. 2005..These results indicate that met allele load and presumably enhanced dopaminergic tone improve the "efficiency" of local circuit processing within the cingulate cortex and thereby its function during AC... - COMT Val158Met polymorphism predicts negative symptoms response to treatment with olanzapine in schizophreniaAlessandro Bertolino
Schizophr Res 95:253-5. 2007 - Brain regions underlying response inhibition and interference monitoring and suppressionGiuseppe Blasi
CBDB, GCAP, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Bethesda, MD 20982-1379, USA
Eur J Neurosci 23:1658-64. 2006..These results extend previous findings by suggesting regional functional specialization within a cortical network supporting cognitive control... - In vivo NMR measures of NAA and the neurobiology of schizophreniaStefano Marenco
Genes, Cognition and Psychosis Program, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Adv Exp Med Biol 576:227-40; discussion 361-3. 2006 - Independent component model of the default-mode brain function: Assessing the impact of active thinkingFabrizio Esposito
Department of Neurological Sciences, University of Naples Federico II, II Policlinico Nuovo Policlinico Padiglione 17, Via S Pansini 5, 80131 Naples, Italy
Brain Res Bull 70:263-9. 2006.... - Differentiating allocation of resources and conflict detection within attentional control processingGiuseppe Blasi
National Institute of Mental Health, National Institutes of Health, Bethesda, MA, USA
Eur J Neurosci 25:594-602. 2007.... - Dissociating the effects of Sternberg working memory demands in prefrontal cortexMario Altamura
Department of Biomedical Sciences, Psychiatry Unit, University of Foggia, Italy
Psychiatry Res 154:103-14. 2007..These results suggest the possibility that top-down modulation of attention or cognitive control at encoding and/or decisionmaking may be mediated by these areas... - Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memoryYing Zhang
Program in Pharmacogenomics, Department of Pharmacology, Ohio State University, Columbus, OH 43210, USA
Proc Natl Acad Sci U S A 104:20552-7. 2007..Our results identify regulatory DRD2 polymorphisms that modify mRNA expression and splicing and working memory pathways... - Dopaminergic modulation of cortical function in patients with Parkinson's diseaseVenkata S Mattay
Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20982 1379, USA
Ann Neurol 51:156-64. 2002....