Alessandro Bertolino

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. ncbi request reprint Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
    J Neurosci 26:3918-22. 2006
  2. ncbi request reprint Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Psychiatry Res 147:221-6. 2006
  3. ncbi request reprint Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder
    Alessandro Bertolino
    Department of Psychiatry and Neurological Sciences, University of Bari, Italy
    Am J Psychiatry 160:483-9. 2003
  4. ncbi request reprint Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 57:1517-25. 2005
  5. ncbi request reprint Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia
    Alessandro Bertolino
    Dipartimento di Scienze Neurologiche e Psichiatriche, Universita degli Studi di Bari, Piazza Giulio Cesare 9, 70124, Bari, Italy
    Am J Psychiatry 161:1798-805. 2004
  6. doi request reprint Epistasis between dopamine regulating genes identifies a nonlinear response of the human hippocampus during memory tasks
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 64:226-34. 2008
  7. doi request reprint Nonlinear response of the anterior cingulate and prefrontal cortex in schizophrenia as a function of variable attentional control
    Giuseppe Blasi
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari 70124, Italy
    Cereb Cortex 20:837-45. 2010
  8. pmc Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans
    Giuseppe Blasi
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
    J Neurosci 29:14812-9. 2009
  9. pmc Treatment with olanzapine is associated with modulation of the default mode network in patients with Schizophrenia
    Fabio Sambataro
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Neuropsychopharmacology 35:904-12. 2010
  10. ncbi request reprint Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 60:1250-8. 2006

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
    J Neurosci 26:3918-22. 2006
    ..These results demonstrate additive genetic effects of genes regulating dopamine signaling on specific neuronal networks subserving working memory...
  2. ncbi request reprint Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Psychiatry Res 147:221-6. 2006
    ..We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex...
  3. ncbi request reprint Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder
    Alessandro Bertolino
    Department of Psychiatry and Neurological Sciences, University of Bari, Italy
    Am J Psychiatry 160:483-9. 2003
    ..In addition, they assessed the relationship between N-acetylaspartate levels and working memory deficits...
  4. ncbi request reprint Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 57:1517-25. 2005
    ..The objective of this study was to explore the relevance of personality style for variability of amygdala response...
  5. ncbi request reprint Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia
    Alessandro Bertolino
    Dipartimento di Scienze Neurologiche e Psichiatriche, Universita degli Studi di Bari, Piazza Giulio Cesare 9, 70124, Bari, Italy
    Am J Psychiatry 161:1798-805. 2004
    ....
  6. doi request reprint Epistasis between dopamine regulating genes identifies a nonlinear response of the human hippocampus during memory tasks
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 64:226-34. 2008
    ..Here, we investigated the effect of genetic variation of dopamine inactivation via catechol-O-methyltransferase (COMT) and the dopamine transporter (DAT) on hippocampal activity in healthy humans during different memory conditions...
  7. doi request reprint Nonlinear response of the anterior cingulate and prefrontal cortex in schizophrenia as a function of variable attentional control
    Giuseppe Blasi
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari 70124, Italy
    Cereb Cortex 20:837-45. 2010
    ....
  8. pmc Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans
    Giuseppe Blasi
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
    J Neurosci 29:14812-9. 2009
    ..These results suggest that genetically determined D(2) signaling may explain part of personality traits related to emotion processing and individual variability in specific brain responses to emotionally relevant inputs...
  9. pmc Treatment with olanzapine is associated with modulation of the default mode network in patients with Schizophrenia
    Fabio Sambataro
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Neuropsychopharmacology 35:904-12. 2010
    ..These results suggest that treatment with olanzapine is associated with the modulation of DMN connectivity in schizophrenia. In addition, our findings suggest critical functional differences in the regions of DMN...
  10. ncbi request reprint Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 60:1250-8. 2006
    ..This network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal cortex (VLPFC). Studies in animals have suggested that the relationship between these brain regions is strongly modulated by dopamine...
  11. pmc Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
    J Neurosci 29:1224-34. 2009
    ..Together, our results demonstrate that the interaction between genetic variants in DRD(2) and DAT critically modulates the nonlinear relationship between dopamine and neuronal activity during memory processing...
  12. ncbi request reprint Activity in medial prefrontal cortex during cognitive evaluation of threatening stimuli as a function of personality style
    Valeria Rubino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Brain Res Bull 74:250-7. 2007
    ..These findings are consistent with the contention that cognitive evaluation and salience of emotional stimuli are associated with different personality styles...
  13. doi request reprint Association of GSK-3β genetic variation with GSK-3β expression, prefrontal cortical thickness, prefrontal physiology, and schizophrenia
    Giuseppe Blasi
    Group of Psychiatric Neuroscience, Department of Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, Italy
    Am J Psychiatry 170:868-76. 2013
    ..CONCLUSIONS These results suggest that GSK-3β variation is implicated in multiple phenotypes relevant to schizophrenia. ..
  14. pmc Association of the SerCys DISC1 polymorphism with human hippocampal formation gray matter and function during memory encoding
    Annabella Di Giorgio
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Eur J Neurosci 28:2129-36. 2008
    ..Moreover, they support the hypothesis that genetic variation in DISC1 may affect the risk for schizophrenia by modifying hippocampal gray matter and function...
  15. pmc Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia
    Alessandro Bertolino
    Department of Neurology and Psychiatry, University of Bari, Bari, Italy
    Brain 132:417-25. 2009
    ..Our results indicate that the three functional DRD2 variants modulate schizophrenia phenotypes possibly by modifying D2S/D2L ratios in the context of different total D2 density...
  16. pmc Changes in prefrontal and amygdala activity during olanzapine treatment in schizophrenia
    Giuseppe Blasi
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Psychiatry Res 173:31-8. 2009
    ..These results suggest that longitudinal treatment with olanzapine may be associated with specific changes in activity of the amygdala and prefrontal cortex during emotional processing in schizophrenia...
  17. doi request reprint D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans
    Leonardo Fazio
    Department of Neurological and Psychiatric Sciences, University of Bari Aldo Moro, Bari, Italy
    Neuroimage 54:2915-21. 2011
    ....
  18. pmc Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    PLoS ONE 5:e9348. 2010
    ..However, the effect of functional genetic variation of DRD2 on striatal dopamine D2 signaling and on its correlation with prefrontal activity during working memory in humans is not known...
  19. ncbi request reprint Functional lateralization of the sensorimotor cortex in patients with schizophrenia: effects of treatment with olanzapine
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 56:190-7. 2004
    ..The objective of the present longitudinal study was to evaluate whether such cortical abnormalities represent state or trait phenomena of the disorder...
  20. ncbi request reprint Hippocampal neurochemical pathology in patients at first episode of affective psychosis: a proton magnetic resonance spectroscopic imaging study
    Giuseppe Blasi
    Psychiatric Neuroscience Group, Department of Psychiatric and Neurological Sciences, University of Bari, Piazza Giulio Cesare, 9, 70124, Bari, Italy
    Psychiatry Res 131:95-105. 2004
    ..Since these data were obtained in patients at first episode, they cannot be explained by chronicity of illness or pharmacological treatment...
  21. doi request reprint Stress-related methylation of the catechol-O-methyltransferase Val 158 allele predicts human prefrontal cognition and activity
    Gianluca Ursini
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University Aldo Moro, 71024 Bari, Italy
    J Neurosci 31:6692-8. 2011
    ..Moreover, these results demonstrate how stress-related DNA methylation of specific functional alleles impacts directly on human brain physiology beyond sequence variation...
  22. pmc Preferential amygdala reactivity to the negative assessment of neutral faces
    Giuseppe Blasi
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 66:847-53. 2009
    ..We explored human amygdala function during explicit behavioral decision making about discrete emotional facial expressions that can represent socially unambiguous and ambiguous cues...
  23. pmc DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia
    Giuseppe Blasi
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University Aldo Moro, 70124 Bari, Italy
    Proc Natl Acad Sci U S A 108:1158-63. 2011
    ..Our results also lend support to further investigation of this downstream molecular pathway in the etiology and treatment of this disorder...
  24. doi request reprint Converging evidence for the association of functional genetic variation in the serotonin receptor 2a gene with prefrontal function and olanzapine treatment
    Giuseppe Blasi
    Group of Psychiatric Neuroscience, Department of Neuroscience and Sense Organs, Aldo Moro University, Bari, Italy
    JAMA Psychiatry 70:921-30. 2013
    ..A single-nucleotide polymorphism in the 5-HT2AR gene (HTR2A rs6314, C>T; OMIM 182135) has been weakly associated with differential 5-HT2AR signaling and with physiologic as well as behavioral effects...
  25. ncbi request reprint Preferential responses in amygdala and insula during presentation of facial contempt and disgust
    Fabio Sambataro
    Department of Psychiatry, University of Bari, Piazza Giulio Cesare, 9, 70124 Bari, Italy
    Eur J Neurosci 24:2355-62. 2006
    ..Our findings suggest preferential involvement of different neural substrates in the processing of facial emotional expressions of contempt and disgust...
  26. pmc DAT by perceived MC interaction on human prefrontal activity and connectivity during emotion processing
    Paolo Taurisano
    Dipartimento di Scienze Neurologiche e Psichiatriche, Università degli Studi di Bari Piazza Giulio Cesare 11, 70124 Bari, Italy
    Soc Cogn Affect Neurosci 8:855-62. 2013
    ..Here, we investigated the interaction between perceived MC and DAT 3'VNTR genotype on brain activity during processing of aversive facial emotional stimuli...
  27. ncbi request reprint DRD2 genotype predicts prefrontal activity during working memory after stimulation of D2 receptors with bromocriptine
    Barbara Gelao
    Group of Psychiatric Neuroscience, Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro, Bari, 70124, Italy
    Psychopharmacology (Berl) 231:2361-70. 2014
    ..The T allele of a functional single-nucleotide polymorphism (SNP) within DRD2 (rs1076560 G > T) predicts reduced relative expression of the D2S receptor isoform and less efficient neural cortical responses during WM tasks...
  28. pmc Expression of DISC1-Interactome Members Correlates with Cognitive Phenotypes Related to Schizophrenia
    Antonio Rampino
    Medical Genetics Section, Centre for Genomic and Experimental Medicine, Medical Research Council Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, United Kingdom Department of Neuroscience and Sense Organs, University of Bari, Bari, Italy
    PLoS ONE 9:e99892. 2014
    ....
  29. doi request reprint Cortical gray matter changes in primary blepharospasm: a voxel-based morphometry study
    Davide Martino
    Neurological Section, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 26:1907-12. 2011
    ..Gray matter changes in the primary sensory cortex may represent a common trait of primary dystonias, including blepharospasm...
  30. pmc Imaging genomics and response to treatment with antipsychotics in schizophrenia
    Giuseppe Blasi
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy 70125
    NeuroRx 3:117-30. 2006
    ..Preliminary evidence with potential susceptilibity genes such as COMT, DISC1, and GRM3 support these assumptions...
  31. ncbi request reprint Incomplete penetrance of NRXN1 deletions in families with schizophrenia
    Giovanna Todarello
    Psychiatric Neuroscience Group, Department of Basic Medical Science, Neuroscience and Sense Organs, University of Bari, Italy
    Schizophr Res 155:1-7. 2014
    ....
  32. ncbi request reprint The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    Michael F Egan
    Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
    Cell 112:257-69. 2003
    ..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF...
  33. ncbi request reprint Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging
    Alessandro Bertolino
    Clinical Brain Disorders Branch, Intramural Research Programs, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 53:906-13. 2003
    ..The objective of this study was to assess possible NAA reductions in hippocampus and prefrontal regions in patients with bipolar disorder...
  34. ncbi request reprint Reduced N-acetylaspartate in prefrontal cortex of adult rats with neonatal hippocampal damage
    Alessandro Bertolino
    Clinical Brain Disorders Branch, Intramural Research Programs, National Institute of Mental Health, NIH, 10 Center Drive Room 4S235 MSC 1379, Bethesda, MD 20892, USA
    Cereb Cortex 12:983-90. 2002
    ....
  35. ncbi request reprint Dopaminergic modulation of cortical function in patients with Parkinson's disease
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20982 1379, USA
    Ann Neurol 51:156-64. 2002
    ....
  36. ncbi request reprint Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia
    Joseph H Callicott
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20982 1389, USA
    Am J Psychiatry 160:709-19. 2003
    ..Earlier family studies have suggested that deficits in executive cognition and working memory may be related to genetic susceptibility for schizophrenia, but the biological basis for this behavioral phenotype has not been identified...
  37. pmc Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia
    Michael F Egan
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:12604-9. 2004
    ..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia...
  38. ncbi request reprint Effect of catechol-O-methyltransferase val158met genotype on attentional control
    Giuseppe Blasi
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 25:5038-45. 2005
    ..These results indicate that met allele load and presumably enhanced dopaminergic tone improve the "efficiency" of local circuit processing within the cingulate cortex and thereby its function during AC...
  39. ncbi request reprint Brain regions underlying response inhibition and interference monitoring and suppression
    Giuseppe Blasi
    CBDB, GCAP, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Bethesda, MD 20982 1379, USA
    Eur J Neurosci 23:1658-64. 2006
    ..These results extend previous findings by suggesting regional functional specialization within a cortical network supporting cognitive control...
  40. ncbi request reprint In vivo NMR measures of NAA and the neurobiology of schizophrenia
    Stefano Marenco
    Genes, Cognition and Psychosis Program, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Adv Exp Med Biol 576:227-40; discussion 361-3. 2006
  41. ncbi request reprint Independent component model of the default-mode brain function: Assessing the impact of active thinking
    Fabrizio Esposito
    Department of Neurological Sciences, University of Naples Federico II, II Policlinico Nuovo Policlinico Padiglione 17, Via S Pansini 5, 80131 Naples, Italy
    Brain Res Bull 70:263-9. 2006
    ....
  42. ncbi request reprint Differentiating allocation of resources and conflict detection within attentional control processing
    Giuseppe Blasi
    National Institute of Mental Health, National Institutes of Health, Bethesda, MA, USA
    Eur J Neurosci 25:594-602. 2007
    ....
  43. ncbi request reprint Dissociating the effects of Sternberg working memory demands in prefrontal cortex
    Mario Altamura
    Department of Biomedical Sciences, Psychiatry Unit, University of Foggia, Italy
    Psychiatry Res 154:103-14. 2007
    ..These results suggest the possibility that top-down modulation of attention or cognitive control at encoding and/or decisionmaking may be mediated by these areas...
  44. ncbi request reprint COMT Val158Met polymorphism predicts negative symptoms response to treatment with olanzapine in schizophrenia
    Alessandro Bertolino
    Schizophr Res 95:253-5. 2007
  45. pmc Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory
    Ying Zhang
    Program in Pharmacogenomics, Department of Pharmacology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:20552-7. 2007
    ..Our results identify regulatory DRD2 polymorphisms that modify mRNA expression and splicing and working memory pathways...