A Bertolino

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. pmc DRD2 genotype-based variation of default mode network activity and of its relationship with striatal DAT binding
    Fabio Sambataro
    Brain Center for Motor and Social Cognition, Istituto Italiano di Parma, Italy
    Schizophr Bull 39:206-16. 2013
  2. pmc Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia
    Alessandro Bertolino
    Department of Neurology and Psychiatry, University of Bari, Bari, Italy
    Brain 132:417-25. 2009
  3. pmc Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    PLoS ONE 5:e9348. 2010
  4. doi request reprint Epistasis between dopamine regulating genes identifies a nonlinear response of the human hippocampus during memory tasks
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 64:226-34. 2008
  5. doi request reprint The genetics of schizophrenia
    A Bertolino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Neuroscience 164:288-99. 2009
  6. pmc Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
    J Neurosci 29:1224-34. 2009
  7. doi request reprint Interaction between catechol-O-methyltransferase (COMT) Val158Met genotype and genetic vulnerability to schizophrenia during explicit processing of aversive facial stimuli
    L Lo Bianco
    Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy
    Psychol Med 43:279-92. 2013
  8. doi request reprint Catechol-O-methyltransferase Val(158)Met association with parahippocampal physiology during memory encoding in schizophrenia
    A Di Giorgio
    Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy
    Psychol Med 41:1721-31. 2011
  9. doi request reprint Load-dependent dysfunction of the putamen during attentional processing in patients with clinically isolated syndrome suggestive of multiple sclerosis
    C Tortorella
    Department of Neuroscience and Sense Organs, University of Bari, Italy
    Mult Scler 19:1153-60. 2013
  10. ncbi request reprint Functional imaging as a tool to investigate the relationship between genetic variation and response to treatment with antipsychotics
    A Di Giorgio
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Curr Pharm Des 15:2560-72. 2009

Collaborators

Detail Information

Publications35

  1. pmc DRD2 genotype-based variation of default mode network activity and of its relationship with striatal DAT binding
    Fabio Sambataro
    Brain Center for Motor and Social Cognition, Istituto Italiano di Parma, Italy
    Schizophr Bull 39:206-16. 2013
    ..These results suggest that genetically determined D2 receptor signaling is associated with DMN connectivity and that these changes are correlated with striatal function and presynaptic DA signaling...
  2. pmc Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia
    Alessandro Bertolino
    Department of Neurology and Psychiatry, University of Bari, Bari, Italy
    Brain 132:417-25. 2009
    ..Our results indicate that the three functional DRD2 variants modulate schizophrenia phenotypes possibly by modifying D2S/D2L ratios in the context of different total D2 density...
  3. pmc Genetically determined measures of striatal D2 signaling predict prefrontal activity during working memory performance
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    PLoS ONE 5:e9348. 2010
    ..However, the effect of functional genetic variation of DRD2 on striatal dopamine D2 signaling and on its correlation with prefrontal activity during working memory in humans is not known...
  4. doi request reprint Epistasis between dopamine regulating genes identifies a nonlinear response of the human hippocampus during memory tasks
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 64:226-34. 2008
    ..Here, we investigated the effect of genetic variation of dopamine inactivation via catechol-O-methyltransferase (COMT) and the dopamine transporter (DAT) on hippocampal activity in healthy humans during different memory conditions...
  5. doi request reprint The genetics of schizophrenia
    A Bertolino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Neuroscience 164:288-99. 2009
    ....
  6. pmc Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
    J Neurosci 29:1224-34. 2009
    ..Together, our results demonstrate that the interaction between genetic variants in DRD(2) and DAT critically modulates the nonlinear relationship between dopamine and neuronal activity during memory processing...
  7. doi request reprint Interaction between catechol-O-methyltransferase (COMT) Val158Met genotype and genetic vulnerability to schizophrenia during explicit processing of aversive facial stimuli
    L Lo Bianco
    Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy
    Psychol Med 43:279-92. 2013
    ..The aim of the present study was to investigate whether genetic risk for schizophrenia and COMT Val158Met genotype interact on brain activity during implicit and explicit emotion processing...
  8. doi request reprint Catechol-O-methyltransferase Val(158)Met association with parahippocampal physiology during memory encoding in schizophrenia
    A Di Giorgio
    Psychiatric Neuroscience Group, Department of Psychiatry and Neurology, University of Bari, Italy
    Psychol Med 41:1721-31. 2011
    ..The aim of the present study was to compare the effects of the COMT Val158Met genotype on parahippocampal and hippocampal physiology during encoding of recognition memory in patients with schizophrenia and in healthy subjects...
  9. doi request reprint Load-dependent dysfunction of the putamen during attentional processing in patients with clinically isolated syndrome suggestive of multiple sclerosis
    C Tortorella
    Department of Neuroscience and Sense Organs, University of Bari, Italy
    Mult Scler 19:1153-60. 2013
    ..No data are available in clinically isolated syndrome (CIS) suggestive of MS...
  10. ncbi request reprint Functional imaging as a tool to investigate the relationship between genetic variation and response to treatment with antipsychotics
    A Di Giorgio
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Curr Pharm Des 15:2560-72. 2009
    ..Moreover, we propose to use Imaging Genetics as a tool to evaluate and predict response to treatment with antipsychotics based on the individual genetic makeup...
  11. pmc Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory
    Ying Zhang
    Program in Pharmacogenomics, Department of Pharmacology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:20552-7. 2007
    ..Our results identify regulatory DRD2 polymorphisms that modify mRNA expression and splicing and working memory pathways...
  12. ncbi request reprint Activity in medial prefrontal cortex during cognitive evaluation of threatening stimuli as a function of personality style
    Valeria Rubino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Brain Res Bull 74:250-7. 2007
    ..These findings are consistent with the contention that cognitive evaluation and salience of emotional stimuli are associated with different personality styles...
  13. ncbi request reprint COMT Val158Met polymorphism predicts negative symptoms response to treatment with olanzapine in schizophrenia
    Alessandro Bertolino
    Schizophr Res 95:253-5. 2007
  14. ncbi request reprint Dissociating the effects of Sternberg working memory demands in prefrontal cortex
    Mario Altamura
    Department of Biomedical Sciences, Psychiatry Unit, University of Foggia, Italy
    Psychiatry Res 154:103-14. 2007
    ..These results suggest the possibility that top-down modulation of attention or cognitive control at encoding and/or decisionmaking may be mediated by these areas...
  15. ncbi request reprint Differentiating allocation of resources and conflict detection within attentional control processing
    Giuseppe Blasi
    National Institute of Mental Health, National Institutes of Health, Bethesda, MA, USA
    Eur J Neurosci 25:594-602. 2007
    ....
  16. ncbi request reprint Preferential responses in amygdala and insula during presentation of facial contempt and disgust
    Fabio Sambataro
    Department of Psychiatry, University of Bari, Piazza Giulio Cesare, 9, 70124 Bari, Italy
    Eur J Neurosci 24:2355-62. 2006
    ..Our findings suggest preferential involvement of different neural substrates in the processing of facial emotional expressions of contempt and disgust...
  17. ncbi request reprint Independent component model of the default-mode brain function: Assessing the impact of active thinking
    Fabrizio Esposito
    Department of Neurological Sciences, University of Naples Federico II, II Policlinico Nuovo Policlinico Padiglione 17, Via S Pansini 5, 80131 Naples, Italy
    Brain Res Bull 70:263-9. 2006
    ....
  18. ncbi request reprint Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Psychiatry Res 147:221-6. 2006
    ..We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex...
  19. ncbi request reprint Prefrontal-hippocampal coupling during memory processing is modulated by COMT val158met genotype
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 60:1250-8. 2006
    ..This network includes the hippocampal formation (HF) as well as the ventrolateral prefrontal cortex (VLPFC). Studies in animals have suggested that the relationship between these brain regions is strongly modulated by dopamine...
  20. ncbi request reprint Reduced N-acetylaspartate in prefrontal cortex of adult rats with neonatal hippocampal damage
    Alessandro Bertolino
    Clinical Brain Disorders Branch, Intramural Research Programs, National Institute of Mental Health, NIH, 10 Center Drive Room 4S235 MSC 1379, Bethesda, MD 20892, USA
    Cereb Cortex 12:983-90. 2002
    ....
  21. ncbi request reprint The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
    Michael F Egan
    Clinical Brain Disorders Branch, National Institute of Mental Health, Room 4s 235, 10 Center Drive, Bethesda, MD 20892, USA
    Cell 112:257-69. 2003
    ..These results demonstrate a role for BDNF and its val/met polymorphism in human memory and hippocampal function and suggest val/met exerts these effects by impacting intracellular trafficking and activity-dependent secretion of BDNF...
  22. ncbi request reprint Working memory deficits and levels of N-acetylaspartate in patients with schizophreniform disorder
    Alessandro Bertolino
    Department of Psychiatry and Neurological Sciences, University of Bari, Italy
    Am J Psychiatry 160:483-9. 2003
    ..In addition, they assessed the relationship between N-acetylaspartate levels and working memory deficits...
  23. ncbi request reprint Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia
    Joseph H Callicott
    Clinical Brain Disorders Branch, IRP, NIMH, NIH, Bethesda, MD 20982 1389, USA
    Am J Psychiatry 160:709-19. 2003
    ..Earlier family studies have suggested that deficits in executive cognition and working memory may be related to genetic susceptibility for schizophrenia, but the biological basis for this behavioral phenotype has not been identified...
  24. ncbi request reprint Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging
    Alessandro Bertolino
    Clinical Brain Disorders Branch, Intramural Research Programs, National Institutes of Health, Bethesda, Maryland 20892, USA
    Biol Psychiatry 53:906-13. 2003
    ..The objective of this study was to assess possible NAA reductions in hippocampus and prefrontal regions in patients with bipolar disorder...
  25. ncbi request reprint Functional lateralization of the sensorimotor cortex in patients with schizophrenia: effects of treatment with olanzapine
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 56:190-7. 2004
    ..The objective of the present longitudinal study was to evaluate whether such cortical abnormalities represent state or trait phenomena of the disorder...
  26. pmc Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia
    Michael F Egan
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health NIH DHHS, Building 10, Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:12604-9. 2004
    ..These convergent data point to a specific molecular pathway by which GRM3 genotype alters glutamate neurotransmission, prefrontal and hippocampal physiology and cognition, and thereby increased risk for schizophrenia...
  27. ncbi request reprint Hippocampal neurochemical pathology in patients at first episode of affective psychosis: a proton magnetic resonance spectroscopic imaging study
    Giuseppe Blasi
    Psychiatric Neuroscience Group, Department of Psychiatric and Neurological Sciences, University of Bari, Piazza Giulio Cesare, 9, 70124, Bari, Italy
    Psychiatry Res 131:95-105. 2004
    ..Since these data were obtained in patients at first episode, they cannot be explained by chronicity of illness or pharmacological treatment...
  28. ncbi request reprint Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia
    Alessandro Bertolino
    Dipartimento di Scienze Neurologiche e Psichiatriche, Universita degli Studi di Bari, Piazza Giulio Cesare 9, 70124, Bari, Italy
    Am J Psychiatry 161:1798-805. 2004
    ....
  29. ncbi request reprint Effect of catechol-O-methyltransferase val158met genotype on attentional control
    Giuseppe Blasi
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1379, USA
    J Neurosci 25:5038-45. 2005
    ..These results indicate that met allele load and presumably enhanced dopaminergic tone improve the "efficiency" of local circuit processing within the cingulate cortex and thereby its function during AC...
  30. ncbi request reprint Variation of human amygdala response during threatening stimuli as a function of 5'HTTLPR genotype and personality style
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Section on Mental Disorders, Department of Psychiatric and Neurological Sciences, University of Bari, Bari, Italy
    Biol Psychiatry 57:1517-25. 2005
    ..The objective of this study was to explore the relevance of personality style for variability of amygdala response...
  31. pmc Imaging genomics and response to treatment with antipsychotics in schizophrenia
    Giuseppe Blasi
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy 70125
    NeuroRx 3:117-30. 2006
    ..Preliminary evidence with potential susceptilibity genes such as COMT, DISC1, and GRM3 support these assumptions...
  32. ncbi request reprint Brain regions underlying response inhibition and interference monitoring and suppression
    Giuseppe Blasi
    CBDB, GCAP, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Building 10, Center Drive, Bethesda, MD 20982 1379, USA
    Eur J Neurosci 23:1658-64. 2006
    ..These results extend previous findings by suggesting regional functional specialization within a cortical network supporting cognitive control...
  33. ncbi request reprint Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain
    Alessandro Bertolino
    Psychiatric Neuroscience Group, Department of Neurological and Psychiatric Sciences, University of Bari, 70124 Bari, Italy
    J Neurosci 26:3918-22. 2006
    ..These results demonstrate additive genetic effects of genes regulating dopamine signaling on specific neuronal networks subserving working memory...
  34. ncbi request reprint In vivo NMR measures of NAA and the neurobiology of schizophrenia
    Stefano Marenco
    Genes, Cognition and Psychosis Program, Division of Intramural Research, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Adv Exp Med Biol 576:227-40; discussion 361-3. 2006
  35. ncbi request reprint Dopaminergic modulation of cortical function in patients with Parkinson's disease
    Venkata S Mattay
    Clinical Brain Disorders Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20982 1379, USA
    Ann Neurol 51:156-64. 2002
    ....