Paolo Bernardi

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi request reprint The mitochondrial permeability transition from in vitro artifact to disease target
    Paolo Bernardi
    Department of Biomedical Sciences and CNR Institute of Neurosciences, University of Padova, Italy
    FEBS J 273:2077-99. 2006
  2. pmc The mitochondrial permeability transition pore: a mystery solved?
    Paolo Bernardi
    Department of Biomedical Sciences, University of Padova Padova, Italy
    Front Physiol 4:95. 2013
  3. pmc Mitochondrial dysfunction and defective autophagy in the pathogenesis of collagen VI muscular dystrophies
    Paolo Bernardi
    Department of Biomedical Sciences, University of Padova, I 35121 Padova, Italy
    Cold Spring Harb Perspect Biol 5:a011387. 2013
  4. pmc EBEC 2012--an energetic time in Freiburg
    Paolo Bernardi
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    EMBO Rep 14:7-9. 2013
  5. pmc The permeability transition pore as a Ca(2+) release channel: new answers to an old question
    Paolo Bernardi
    Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Padova, Italy
    Cell Calcium 52:22-7. 2012
  6. doi request reprint Dysfunction of mitochondria and sarcoplasmic reticulum in the pathogenesis of collagen VI muscular dystrophies
    Paolo Bernardi
    Department of Biomedical Sciences, University of Padova, Viale Guiseppe Colombo, Padova, Italy
    Ann N Y Acad Sci 1147:303-11. 2008
  7. doi request reprint Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice
    Elena Palma
    Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy
    Hum Mol Genet 18:2024-31. 2009
  8. ncbi request reprint Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D
    Emy Basso
    Department of Biomedical Sciences and Consiglio Nazionale delle Ricerche Institute of Neuroscience, University of Padova, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    J Biol Chem 280:18558-61. 2005
  9. doi request reprint Modulation of mitochondrial K(+) permeability and reactive oxygen species production by the p13 protein of human T-cell leukemia virus type 1
    Micol Silic-Benussi
    Department of Oncology and Surgical Sciences, University of Padova, I 35128 Padova, Italy
    Biochim Biophys Acta 1787:947-54. 2009
  10. doi request reprint The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide
    Alessandra Zulian
    C N R Institute of Neurosciences at the Department of Biomedical Sciences, University of Padova, Italy
    Biochim Biophys Acta 1807:1600-5. 2011

Collaborators

Detail Information

Publications69

  1. ncbi request reprint The mitochondrial permeability transition from in vitro artifact to disease target
    Paolo Bernardi
    Department of Biomedical Sciences and CNR Institute of Neurosciences, University of Padova, Italy
    FEBS J 273:2077-99. 2006
    ..Finally, we discuss evidence indicating that the permeability transition pore plays a role in pathophysiology, with specific emphasis on in vivo models of disease...
  2. pmc The mitochondrial permeability transition pore: a mystery solved?
    Paolo Bernardi
    Department of Biomedical Sciences, University of Padova Padova, Italy
    Front Physiol 4:95. 2013
    ..Open questions remain, but there is now promise that the PTP can be studied by genetic methods to solve the large number of outstanding problems...
  3. pmc Mitochondrial dysfunction and defective autophagy in the pathogenesis of collagen VI muscular dystrophies
    Paolo Bernardi
    Department of Biomedical Sciences, University of Padova, I 35121 Padova, Italy
    Cold Spring Harb Perspect Biol 5:a011387. 2013
    ....
  4. pmc EBEC 2012--an energetic time in Freiburg
    Paolo Bernardi
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    EMBO Rep 14:7-9. 2013
    ..The conference is a biannual event that brings together researchers from across the globe to discuss progress in this diverse and challenging field...
  5. pmc The permeability transition pore as a Ca(2+) release channel: new answers to an old question
    Paolo Bernardi
    Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Padova, Italy
    Cell Calcium 52:22-7. 2012
    ..We also address the relevance of a mitochondrial Ca(2+) release channel recently discovered in Drosophila melanogaster, which possesses intermediate features between the permeability transition pore of yeast and mammals...
  6. doi request reprint Dysfunction of mitochondria and sarcoplasmic reticulum in the pathogenesis of collagen VI muscular dystrophies
    Paolo Bernardi
    Department of Biomedical Sciences, University of Padova, Viale Guiseppe Colombo, Padova, Italy
    Ann N Y Acad Sci 1147:303-11. 2008
    ....
  7. doi request reprint Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice
    Elena Palma
    Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy
    Hum Mol Genet 18:2024-31. 2009
    ....
  8. ncbi request reprint Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D
    Emy Basso
    Department of Biomedical Sciences and Consiglio Nazionale delle Ricerche Institute of Neuroscience, University of Padova, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    J Biol Chem 280:18558-61. 2005
    ..These results have major implications for our current understanding of the PTP and its modulation in vitro and in vivo...
  9. doi request reprint Modulation of mitochondrial K(+) permeability and reactive oxygen species production by the p13 protein of human T-cell leukemia virus type 1
    Micol Silic-Benussi
    Department of Oncology and Surgical Sciences, University of Padova, I 35128 Padova, Italy
    Biochim Biophys Acta 1787:947-54. 2009
    ..The downstream consequences of p13-induced mitochondrial K(+) permeability are likely to have an important influence on the redox state and turnover of HTLV-1-infected cells...
  10. doi request reprint The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide
    Alessandra Zulian
    C N R Institute of Neurosciences at the Department of Biomedical Sciences, University of Padova, Italy
    Biochim Biophys Acta 1807:1600-5. 2011
    ..Thus, species-specificity of NRB toward the rat PT depends on subtle differences in the structure of TSPO or of TSPO-associated proteins affecting its substrate specificity...
  11. pmc Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation
    Emy Basso
    Department of Biomedical Sciences and Consiglio Nazionale delle Ricerche Institute of Neuroscience, University of Padova, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    J Biol Chem 283:26307-11. 2008
    ..These findings call for a reassessment of conclusions on the role of the PTP in cell death that are based on the effects of CsA or of CyP-D ablation...
  12. doi request reprint Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration
    Paolo Grumati
    Department of Histology, Microbiology and Medical Biotechnology, University of Padova, Padova, Italy
    Nat Med 16:1313-20. 2010
    ..These findings indicate that defective activation of the autophagic machinery is pathogenic in some congenital muscular dystrophies...
  13. pmc Dimers of mitochondrial ATP synthase form the permeability transition pore
    Valentina Giorgio
    Consiglio Nazionale delle Ricerche Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, 35121 Padua, Italy
    Proc Natl Acad Sci U S A 110:5887-92. 2013
    ..Channel openings were inhibited by the ATP synthase inhibitor AMP-PNP (γ-imino ATP, a nonhydrolyzable ATP analog) and Mg(2+)/ADP. These results indicate that the PTP forms from dimers of the ATP synthase...
  14. pmc Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex
    Valentina Giorgio
    Department of Biomedical Sciences and the Consiglio Nazionale delle Ricerche Institute of Neuroscience, University of Padova, I 35121 Padova, Italy
    J Biol Chem 284:33982-8. 2009
    ..These findings demonstrate that CyPD association to the lateral stalk of ATP synthase modulates the activity of the complex...
  15. pmc Cyclophilin D in mitochondrial pathophysiology
    Valentina Giorgio
    Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Italy
    Biochim Biophys Acta 1797:1113-8. 2010
    ....
  16. ncbi request reprint The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative
    Eva Milanesi
    Department of Biomedical Sciences and Consiglio Nazionale delle Ricerche Institute of Neurosciences, University of Padova, Viale Giuseppe Colombo 3, I 35121 Padua, Italy
    J Biol Chem 281:10066-72. 2006
    ....
  17. pmc The mitochondrial permeability transition from yeast to mammals
    Luca Azzolin
    Department of Biomedical Sciences, CNR Institute of Neuroscience, University of Padova, Padova, Italy
    FEBS Lett 584:2504-9. 2010
    ..Biochim. Biophys. Acta 1787, 1486-1491] suggest that the mitochondrial permeability transition has been conserved during evolution...
  18. ncbi request reprint Properties of the permeability transition in VDAC1(-/-) mitochondria
    Alexandra Krauskopf
    Department of Biomedical Sciences, University of Padova, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    Biochim Biophys Acta 1757:590-5. 2006
    ..The labeled protein could be separated from all VDAC isoforms. While these results do not allow to exclude that VDAC is part of the PTP, they suggest that VDAC is not the target for PTP inhibition by Ro 68-3400...
  19. pmc Regulation of the inner membrane mitochondrial permeability transition by the outer membrane translocator protein (peripheral benzodiazepine receptor)
    Justina Sileikyte
    Department of Biomedical Sciences, Consiglio Nazionale delle Ricerche Institute of Neuroscience, University of Padova, I 35121 Padova, Italy
    J Biol Chem 286:1046-53. 2011
    ..Thus, the permeability transition is an inner membrane event that is regulated by the outer membrane through specific interactions with TSPO...
  20. doi request reprint Switch from inhibition to activation of the mitochondrial permeability transition during hematoporphyrin-mediated photooxidative stress. Unmasking pore-regulating external thiols
    Valeria Petronilli
    C N R Institute of Neurosciences at the Department of Biomedical Sciences, University of Padova, Italy
    Biochim Biophys Acta 1787:897-904. 2009
    ..These findings shed new light on PTP modulation by oxidative stress...
  21. ncbi request reprint Induction of the mitochondrial permeability transition by the DNA alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine. Sorting cause and consequence of mitochondrial dysfunction
    Giuliano Dodoni
    Dipartimento di Chimica Biologica, Universita di Padova, Viale G Colombo 3, I 35121 Padova, Italy
    Biochim Biophys Acta 1658:58-63. 2004
    ..We conclude that a key event in MNNG-dependent cell death is induction of PTP opening that occurs independently of PARP-1 activation...
  22. doi request reprint Mitochondrial Ca2+ transport and permeability transition in zebrafish (Danio rerio)
    Luca Azzolin
    Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padua, Italy
    Biochim Biophys Acta 1797:1775-9. 2010
    ..Our results represent a necessary step toward the use of zebrafish for the screening and validation of PTP inhibitors of potential use in human diseases, as recently shown for collagen VI muscular dystrophy [Telfer et al., 2010]...
  23. pmc Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition
    Andrea Rasola
    Department of Biomedical Sciences, National Research Council Institute of Neuroscience and Venetian Institute of Molecular Medicine, University of Padua, 35121 Padua, Italy
    Proc Natl Acad Sci U S A 107:726-31. 2010
    ..Thus, in tumor cells mitochondrial ERK activation desensitizes the PTP through a signaling axis that involves GSK-3 and cyclophilin D, a finding that provides a mechanistic basis for increased resistance to apoptosis of neoplastic cells...
  24. doi request reprint The mitochondrial permeability transition pore and cyclophilin D in cardioprotection
    Fabio Di Lisa
    Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, 35121 Padova, Italy
    Biochim Biophys Acta 1813:1316-22. 2011
    ..This article is part of a Special Issue entitled: Mitochondria and Cardioprotection...
  25. pmc Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels
    Federica Chiara
    CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy
    PLoS ONE 3:e1852. 2008
    ..These findings have profound implications for our understanding of the pathways of outer mitochondrial membrane permeabilization and their inactivation in tumors...
  26. doi request reprint A CaPful of mechanisms regulating the mitochondrial permeability transition
    Fabio Di Lisa
    Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Padova, Italy
    J Mol Cell Cardiol 46:775-80. 2009
    ....
  27. pmc Antamanide, a derivative of Amanita phalloides, is a novel inhibitor of the mitochondrial permeability transition pore
    Luca Azzolin
    Department of Biomedical Sciences University of Padova and CNR Institute of Neuroscience, Padova, Italy
    PLoS ONE 6:e16280. 2011
    ..Our findings have implications for the comprehension of cyclophilin D activity on the permeability transition pore and for the development of novel pore-targeting drugs exploitable as cell death inhibitors...
  28. pmc The effects of idebenone on mitochondrial bioenergetics
    Valentina Giorgio
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    Biochim Biophys Acta 1817:363-9. 2012
    ..2011) PLoS One 6, e17963], electron transfer to complex III may allow reoxidation of NADH in complex I deficiencies...
  29. pmc Snake phospholipase A2 neurotoxins enter neurons, bind specifically to mitochondria, and open their transition pores
    Michela Rigoni
    Dipartimento di Scienze Biomediche Sperimentali, Università di Padova and Istituto di Neuroscienze del Consiglio Nazionale delle Ricerche, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    J Biol Chem 283:34013-20. 2008
    ..These findings contribute to define the cellular events that lead to intoxication of nerve terminals by these snake neurotoxins and suggest that mitochondrial impairment is an important determinant of their toxicity...
  30. doi request reprint Induction of the permeability transition pore in cells depleted of mitochondrial DNA
    Ionica Masgras
    University of Padova, Padova, Italy
    Biochim Biophys Acta 1817:1860-6. 2012
    ..This article is part of a Special Issue entitled: 17th European Bioenergetics Conference (EBEC 2012)...
  31. doi request reprint Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis
    Andrea Rasola
    Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Italy
    Cell Calcium 50:222-33. 2011
    ....
  32. doi request reprint Altered threshold of the mitochondrial permeability transition pore in Ullrich congenital muscular dystrophy
    Alessia Angelin
    Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Italy
    Biochim Biophys Acta 1777:893-6. 2008
    ....
  33. ncbi request reprint Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency
    William A Irwin
    Department of Histology, University of Padova, 35121 Padova, Italy
    Nat Genet 35:367-71. 2003
    ..These findings indicate that collagen VI myopathies have an unexpected mitochondrial pathogenesis that could be exploited for therapeutic intervention...
  34. ncbi request reprint Arachidonic acid released by phospholipase A(2) activation triggers Ca(2+)-dependent apoptosis through the mitochondrial pathway
    Daniele Penzo
    Department of Biomedical Sciences, Consiglio Nazionale delle Ricerche Institute of Neuroscience at the University of Padova, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    J Biol Chem 279:25219-25. 2004
    ..These findings identify arachidonic acid as the causal link between A23187-dependent perturbation of Ca(2+) homeostasis and the effector mechanisms of cell death...
  35. ncbi request reprint Effects of fatty acids on mitochondria: implications for cell death
    Daniele Penzo
    Department of Biomedical Sciences and CNR Institute for Neurosciences, University of Padova, Viale Giuseppe Colombo 3, I 35121 Padua, Italy
    Biochim Biophys Acta 1555:160-5. 2002
    ..With few exceptions, depolarization and cell death are due to opening of the PTP rather than to the direct effects of fatty acids on energy coupling...
  36. doi request reprint Cytotoxicity of a mitochondriotropic quercetin derivative: mechanisms
    Nicola Sassi
    Department of Biomedical Sciences, University of Padova, Italy
    Biochim Biophys Acta 1817:1095-106. 2012
    ..Death induction was selective for fast-growing C-26 tumoral cells and mouse embryonic fibroblasts (MEFs) while sparing slow-growing MEFs. This suggests a possible use of Q-7BTPI as a chemotherapeutic agent...
  37. doi request reprint Shedding light on the mitochondrial permeability transition
    Fernanda Ricchelli
    Department of Biology, University of Padova, Padova, Italy
    Biochim Biophys Acta 1807:482-90. 2011
    ....
  38. pmc Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene
    Peter Christian Klohn
    Department of Biomedical Sciences, University of Padua, Viale Giuseppe Colombo 3, I 35121 Padua, Italy
    Proc Natl Acad Sci U S A 100:10014-9. 2003
    ..Both events precede tumor formation, suggesting that suppression of apoptosis may contribute to the selection of a resistant phenotype, eventually increasing the probability of cell progression to the transformed state...
  39. pmc Signal transduction to the permeability transition pore
    Andrea Rasola
    Department of Biomedical Sciences and CNR Institute of Neuroscience, University of Padova, Italy
    FEBS Lett 584:1989-96. 2010
    ..Recent progress on PTP modulation by kinase/phosphatase signal transduction is discussed, with specific emphasis on hexokinase and on the Akt-ERK-GSK3 axis, which might modulate the PTP through CyP-D phosphorylation...
  40. ncbi request reprint Assessing the molecular basis for rat-selective induction of the mitochondrial permeability transition by norbormide
    Alessandra Zulian
    Department of Pharmacology and Anesthesiology Pharmacology Division, University of Padova, Padova, Italy
    Biochim Biophys Acta 1767:980-8. 2007
    ..The species-selectivity may depend on the unique properties of a transport system allowing drug internalisation in rat mitochondria...
  41. ncbi request reprint Mitochondrial energy dissipation by fatty acids. Mechanisms and implications for cell death
    Paolo Bernardi
    Department of Biomedical Sciences, Venetian Institute of Molecular Medicine, University of Padova, I 35131 Padova, Italy
    Vitam Horm 65:97-126. 2002
    ....
  42. doi request reprint Serenoa repens extract targets mitochondria and activates the intrinsic apoptotic pathway in human prostate cancer cells
    Antonella Baron
    Venetian Institute of Molecular Medicine, University of Padova, Padova, Italy
    BJU Int 103:1275-83. 2009
    ....
  43. pmc The mitochondrial chaperone TRAP1 promotes neoplastic growth by inhibiting succinate dehydrogenase
    Marco Sciacovelli
    CNR Institute of Neuroscience, Department of Biomedical Sciences and Venetian Institute of Molecular Medicine, University of Padova, 35121 Padova, Italy
    Cell Metab 17:988-99. 2013
    ..These findings provide a mechanistic clue to explain the switch to aerobic glycolysis of tumors and identify TRAP1 as a promising antineoplastic target...
  44. doi request reprint Lentiviral-mediated RNAi in vivo silencing of Col6a1, a gene with complex tissue specific expression pattern
    Kosjenka Frka
    Department of Histology Microbiology and Medical Biotechnology, University of Padova, Padova, Italy
    J Biotechnol 141:8-17. 2009
    ..Control of expression by the drug was stringent in many tissues; however, in some tissues turning off of siRNA synthesis was not complete. The data support the application of lentiviral vectors used here in transgenesis...
  45. ncbi request reprint The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesis
    Andrea Rasola
    CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Viale Giuseppe Colombo 3, I 35121 Padua, Italy
    Apoptosis 12:815-33. 2007
    ..Here we review basic concepts about PTP structure, function and regulation within the framework of intracellular death signalling, and its role in disease pathogenesis...
  46. ncbi request reprint Mitochondria and ischemia-reperfusion injury of the heart: fixing a hole
    Fabio Di Lisa
    Dipartimento di Chimica Biologica, Universita di Padova, Viale G Colombo 3, 35121 Padova
    Cardiovasc Res 70:191-9. 2006
    ..Here, we discuss our current understanding of the structure and function of PTP in the context of heart injury caused by ischemia and reperfusion...
  47. ncbi request reprint Mitochondria and cardioprotection
    Fabio Di Lisa
    Dipartimento di Chimica Biologica, Universita di Padova, Viale G Colombo 3, Padua 35121, Italy
    Heart Fail Rev 12:249-60. 2007
    ..Finally, mitochondrial targets for therapeutic intervention may include the switch of substrate being utilized, because inhibition of fatty acid oxidation is associated with cardioprotective effects...
  48. ncbi request reprint Mitochondria and reperfusion injury. The role of permeability transition
    Fabio Di Lisa
    Istituto di Neuroscienze del CNR, Universita di Padova, Viale Giuseppe Colombo 3, 35121 Padua, Italy
    Basic Res Cardiol 98:235-41. 2003
    ....
  49. ncbi request reprint Mitochondrial function and myocardial aging. A critical analysis of the role of permeability transition
    Fabio Di Lisa
    Dipartimento di Chimica Biologica, Universita di Padova, Viale G Colombo 3, 35121 Padova, Italy
    Cardiovasc Res 66:222-32. 2005
    ....
  50. ncbi request reprint Mitochondria as functional targets of proteins coded by human tumor viruses
    Donna M D'Agostino
    Department of Oncology and Surgical Sciences, University of Padova, Padova 35128, Italy
    Adv Cancer Res 94:87-142. 2005
    ....
  51. ncbi request reprint Species-specific modulation of the mitochondrial permeability transition by norbormide
    Fernanda Ricchelli
    C N R, Institute of Biomedical Technologies Padova Unit, Department of Biology, University of Padova, Viale Giuseppe Colombo 3, 35121 Padova, Italy
    Biochim Biophys Acta 1708:178-86. 2005
    ..The characterization of the norbormide target may lead to a better understanding of the mechanisms underlying the mitochondrial PTP as well as to the identification of species-specific drugs that affect mitochondrial function...
  52. ncbi request reprint Mitochondrial alterations induced by the p13II protein of human T-cell leukemia virus type 1. Critical role of arginine residues
    Donna M D'Agostino
    Department of Oncology and Surgical Sciences, University of Padova, Via Gattamelata 64, 35128 Padua, Italy
    J Biol Chem 277:34424-33. 2002
    ....
  53. ncbi request reprint The mitochondrial permeability transition pore
    Paolo Bernardi
    Department of Biomedical Sciences and CNR Institute of Neurosciences, University of Padova, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    Novartis Found Symp 287:157-64; discussion 164-9. 2007
    ..While the nature of the components forming the PTP remains controversial, the identification of novel inhibitors that can be used as affinity labels is offering new perspectives towards the molecular definition of the PTP...
  54. ncbi request reprint Bupivacaine myotoxicity is mediated by mitochondria
    William Irwin
    Department of Biomedical Sciences, University of Padova and the Consiglio Nazionale delle Ricerche Units for the Study of Muscle Pathophysiology and Biomembranes, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    J Biol Chem 277:12221-7. 2002
    ....
  55. ncbi request reprint Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis
    Marco Giorgio
    Experimental Oncology Department, European Institute of Oncology, Milan, Italy
    Cell 122:221-33. 2005
    ..These data demonstrate the existence of alternative redox reactions of the mitochondrial electron transfer chain, which evolved to generate proapoptotic ROS in response to specific stress signals...
  56. pmc BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore
    Angela Risso
    Department of Biotechnology and Biomedical Sciences, University of Udine, Via Cotonificio 108, I 33100 Udine, Italy
    Mol Cell Biol 22:1926-35. 2002
    ..Our results demonstrate that BMAP-28 is an inducer of the mitochondrial permeability transition pore and that its cytotoxic potential depends on its effects on mitochondrial permeability...
  57. ncbi request reprint A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis
    Mirella Trinei
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    Oncogene 21:3872-8. 2002
    ..We propose that steady-state levels of intracellular oxidants and oxidative damage are genetically determined and regulated by a stress-induced signal transduction pathway involving p53 and p66Shc...
  58. ncbi request reprint Mitochondria are direct targets of the lipoxygenase inhibitor MK886. A strategy for cell killing by combined treatment with MK886 and cyclooxygenase inhibitors
    Arianna Gugliucci
    Venetian Institute of Molecular Medicine, I 35129 Padova, Italy
    J Biol Chem 277:31789-95. 2002
    ..This approach should be specifically useful to kill cells possessing a high flux of arachidonic acid and its metabolites like prostate and colon cancer cells...
  59. ncbi request reprint Novel mitochondrial creatine transport activity. Implications for intracellular creatine compartments and bioenergetics
    Bernd Walzel
    Swiss Federal Institute of Technology, ETH Zurich, Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    J Biol Chem 277:37503-11. 2002
    ..Our data suggest that mitochondria, shown here to possess creatine transport activity, may harbor such a creatine/phosphocreatine pool...
  60. pmc Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis
    Michael Forte
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 104:7558-63. 2007
    ..Our results directly implicate pathological activation of the mitochondrial PTP in the axonal damage occurring during MS and identify CyPD, as well as the PTP, as a potential target for MS neuroprotective therapies...
  61. ncbi request reprint The voltage-dependent anion channel is the target for a new class of inhibitors of the mitochondrial permeability transition pore
    Andrea M Cesura
    Pharmaceutical Division, Drug Discovery Department, F Hoffmann La Roche Ltd, Grenzacherstrasse 124, CH 4070 Basel, Switzerland
    J Biol Chem 278:49812-8. 2003
    ..While Ro 68-3400 represents a new useful tool for the study of the structure and function of VDAC and the PTP, the results obtained provide direct evidence that VDAC1 is a component of this mitochondrial pore...
  62. ncbi request reprint Ligand-selective modulation of the permeability transition pore by arginine modification. Opposing effects of p-hydroxyphenylglyoxal and phenylglyoxal
    Matts D Linder
    Helsinki Biophysics and Biomembrane Group, Institute of Biomedicine, University of Helsinki, FIN 00014, Helsinki, Finland
    J Biol Chem 277:937-42. 2002
    ..The results indicate that both OH-PGO and PGO react with arginine at a stoichiometry of 2:1 and form stable adducts that may be feasible to identify the PTP at the molecular level...
  63. ncbi request reprint Yessotoxin, a shellfish biotoxin, is a potent inducer of the permeability transition in isolated mitochondria and intact cells
    Cristina Bianchi
    Department of Biochemistry G Moruzzi, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Biochim Biophys Acta 1656:139-47. 2004
    ....
  64. ncbi request reprint Desensitization of the permeability transition pore by cyclosporin a prevents activation of the mitochondrial apoptotic pathway and liver damage by tumor necrosis factor-alpha
    Maria Eugenia Soriano
    Consiglio Nazionale delle Ricerche Institute of Neuroscience at the Department of Biomedical Sciences, University of Padua, Viale Giuseppe Colombo 3, I 35121 Padua, Italy
    J Biol Chem 279:36803-8. 2004
    ....
  65. ncbi request reprint Modification of permeability transition pore arginine(s) by phenylglyoxal derivatives in isolated mitochondria and mammalian cells. Structure-function relationship of arginine ligands
    Milena Johans
    Helsinki Biophysics and Biomembrane Group, Institute of Biomedicine Biochemistry, P O Box 63, University of Helsinki, Helsinki FIN 00014, Finland
    J Biol Chem 280:12130-6. 2005
    ..These results are consistent with a model where the target arginine plays a role as a voltage sensor...
  66. ncbi request reprint Genetic dissection of the permeability transition pore
    Michael Forte
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    J Bioenerg Biomembr 37:121-8. 2005
    ....
  67. pmc Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathies
    Luciano Merlini
    Department of Experimental and Diagnostic Medicine, Section of Medical Genetics, University of Ferrara, I 44100 Ferrara, Italy
    Proc Natl Acad Sci U S A 105:5225-9. 2008
    ....
  68. pmc Mitochondrial deoxynucleotide pool sizes in mouse liver and evidence for a transport mechanism for thymidine monophosphate
    Paola Ferraro
    Departments of Biology and Biomedical Sciences, University of Padua, I 35131 Padua, Italy
    Proc Natl Acad Sci U S A 103:18586-91. 2006
    ..At nM external dTMP the nucleotide is concentrated 100-fold inside the mt matrix. Export of thymidine phosphates was much slower and possibly occurred at the level of dTDP...
  69. ncbi request reprint Identification and characterization of a specific sensory epithelium in the rat larynx
    Andrea Sbarbati
    Department of Morphological Biomedical Sciences, Human Anatomy and Histology Section, University of Verona, 37134 Verona, Italy
    J Comp Neurol 475:188-201. 2004
    ..The immunocytochemical and ultrastructural data suggested that SLSE is a chemoreceptor located in an optimal position for detecting substances entering the larynx from the pharynx or the trachea...