Research Topics
| E BergaminiSummaryAffiliation: University of Pisa Country: Italy Publications
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Publications
Autophagy: a cell repair mechanism that retards ageing and age-associated diseases and can be intensified pharmacologicallyEttore Bergamini
Centro di Ricerca Interdipartimentale di Biologia e Patologia dell Invecchiamento, Via Roma 55, 56126 Pisa, Italy
Mol Aspects Med 27:403-10. 2006....- Targets for antiageing drugsEttore Bergamini
University of Pisa, Centro di Ricerca Interdipartimentale di Biologia e Patologia dell Invecchiamento, Via Roma 55, 56126 Pisa, Italy
Expert Opin Ther Targets 9:77-82. 2005.... - The third European congress on biogerontology: the biogerontological basis of preventive medicine and geriatric practiceE Bergamini
Dept. de Patalogia sperimentale Biotechnologie Mediche, Centro di Ricerca di Biologia e Patologia dell'Invecchiamento of the University of Pisa, Via Roma 55, Pisa 56126, Italy
Exp Gerontol 38:1213-6. 2003 - The role of autophagy in aging: its essential part in the anti-aging mechanism of caloric restrictionEttore Bergamini
Centro di Ricerca di Biologia e Patologia dell Invecchiamento, Dipartimento di Patologia Sperimentale Scuola Medica, Via Roma 55, 56123 Pisa, Italy
Ann N Y Acad Sci 1114:69-78. 2007..It is concluded that the pharmacologic intensification of autophagy (PISA treatment) has anti-aging effects and might prove to be a big step toward retardation of aging and prevention of age-associated diseases in humans... - The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-ageing food restrictionG Cavallini
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia e Epidemiologia, Via Roma 55, 56126, Pisa, Italy
Exp Gerontol 36:497-506. 2001..It is concluded that the data are compatible with the hypothesis that AP and improved membrane maintenance might be involved in the antiageing mechanism of CR... - Age-related changes in the autophagic proteolysis of rat isolated liver cells: effects of antiaging dietary restrictionsA Donati
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Via Roma 55, 56126 Pisa, Italy
J Gerontol A Biol Sci Med Sci 56:B375-83. 2001..It is suggested that improved liver autophagy and lysosomal degradation might be part of the antiaging mechanisms of DR... - Ageing and oxidative stress: a role for dolichol in the antioxidant machinery of cell membranes?E Bergamini
Centro di Ricerca di Biologia e Patologia dell Invecchiamento, Pisa, Italy
J Alzheimers Dis 6:129-35. 2004.... - Effects of ageing and increased haemolysis on the levels of dolichol in rat spleenB Dini
Dipartimento di Patologia Sperimentale, University of Pisa, Biotecnologie Mediche, Infettivologia e Epidemiologia, Via Roma 55, 56126, Pisa, Italy
Exp Gerontol 37:99-105. 2001..Free-radical mediated decomposition of dolichol by phagocytic cells during erythrophagocytosis might be involved in the process... - The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseasesE Bergamini
Centro di Ricerca di Biologia e Patologia dell Invecchiamento, University of Pisa, Scuola Medica, Via Roma 55, 56126 Pisa, Italy
Int J Biochem Cell Biol 36:2392-404. 2004.... - Effects of low-dose VOSO(4) on age-related changes in glucose homeostasis in ratsV De Tata
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia e Epidemiologia, Universita degli Studi di Pisa, Via Roma, 55 Scuola Medica, 56100, Pisa, Italy
Eur J Pharmacol 398:169-75. 2000.... - Effect of aging and anti-aging caloric restriction on the endocrine regulation of rat liver autophagyAlessio Donati
Universita di Pisa, Centro di Ricerca Biologia e Patologia dell Invecchiamento, Roma 55, Pisa, Italy 56126
J Gerontol A Biol Sci Med Sci 63:550-5. 2008..Both DR and EOD maintain the sensitivity to glucagon at juvenile levels, whereas only EOD can fully maintain response to insulin. It is concluded that changes in the sensitivity to glucagon may have a role in the aging process... - Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphismPiero Marchetti
Department of Endocrinology and Metabolism, Metabolic Unit, University of Pisa, Pisa, Italy
Diabetes 51:1419-24. 2002..These alterations may account for the increased predisposition to type 2 diabetes in individuals carrying the Gly(972)-->Arg amino acid polymorphism of IRS-1... - Towards an understanding of the anti-aging mechanism of caloric restrictionGabriella Cavallini
Centro di Ricerca Interdipartimentale di Biologia e Patologia dell Invecchiamento, Universita degli Studi di Pisa, Scuola Medica, Via Roma 55 56126 Pisa, Italy
Curr Aging Sci 1:4-9. 2008..I.S.A. treatment) by the stimulation of autophagy might prove to be a big step towards retardation of aging and prevention of age-associated diseases in humans... - Anti-aging effects of anti-lipolytic drugsAlessio Donati
Centro di Ricerca Interdipartimentale sull'Invecchiamento, , Via Roma 55, 56126, Italy
Exp Gerontol 39:1061-7. 2004..Speculation is that transiently lower plasma insulin levels might stimulate the anti-aging cell-repair mechanism autophagy, which has longer lasting effects on cell housekeeping... - Stimulation of macroautophagy can rescue older cells from 8-OHdG mtDNA accumulation: a safe and easy way to meet goals in the SENS agendaAlessio Donati
Center for Research on Biology and Pathology of Aging, University of Pisa, Pisa, Italy
Rejuvenation Res 9:408-12. 2006.... - Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulatedRoberto Lupi
Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
Diabetes 51:1437-42. 2002..The cytostatic action is likely to be due to the FFA-induced reduction of intraislet glucose metabolism, and the proapoptotic effects are mostly caspase mediated, partially dependent on ceramide pathway, and possibly Bcl-2 regulated... 
Methods for inducing and monitoring liver autophagy relative to aging and antiaging caloric restriction in ratsAlessio Donati
Centro di Ricerca Interdipartimentale di Biologia e Patologia dell Invecchiamento, Universita di Pisa, Pisa, Italy
Methods Enzymol 452:441-55. 2009..The effects of aging on autophagic proteolysis and on amino acid and hormone control can also be assessed by measuring the rate of the 3-methyladenine-sensitive valine released from isolated liver cells incubated in vitro...- The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologicallyE Bergamini
Centro di Ricerca di Biologia e Patologia dell Invecchiamento, University of Pisa, Scuola Medica, Via Roma 55, 56126 Pisa, Italy
Biomed Pharmacother 57:203-8. 2003..It is shown that the life-long weekly administration of an anti-lipolytic drug may decrease glucose and insulin levels and stimulate autophagy and intensify anti-ageing effects of submaximal CR... - The antilipolytic agent 3,5-dimethylpyrazole inhibits insulin release in response to both nutrient secretagogues and cyclic adenosine monophosphate agonists in isolated rat isletsP Masiello
Dipartimento di Patologia Sperimentale, University of Pisa, Pisa, Italy
Metabolism 51:110-4. 2002.... - The fate of dolichol in rat cells and tissuesGabriella Cavallini
Centro di Ricerca Interdipartimentale di Biologia e Patologia dell'Invecchiamento, University of Pisa, Pisa, Italy
Biogerontology 4:347-51. 2003..No significant net redistribution of D was observed from the transplanted older heart to liver and tissues of younger recipients. In conclusion, phagocytosis appears to be the only process resulting in the disposal of tissue D... - Evidence for selective mitochondrial autophagy and failure in agingGabriella Cavallini
Centro di Ricerca di Biologia e Patologia dell Invecchiamento, Universita di Pisa, Via Roma 55, Pisa 56126, Italy
Autophagy 3:26-7. 2007..Together, these data provide indirect evidence that 8-OHdG might accumulate in a small pool of mitochondria with increasing age rather than be degraded by the autophagic machinery selectively... - The age-related accumulation of dolichol in rat liver may correlate with expectation of lifeChiara Dolfi
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia e Epidemiologia, University of Pisa, Pisa, Italy
Biogerontology 4:113-8. 2003..The conclusion is that assay of the quantity of dolichol in the liver tissue may be used as a marker of the biological age of the animal and therefore as an important biomarker of ageing... - Deficiency and supplementation of PUFA in the diet have similar effects on the age-associated changes in rat-plasma cholesterol levelsSara Straniero
Centro di Ricerca di Biologia e Patologia dell Invecchiamento, Universita di Pisa, Via Roma 55, 56126 Pisa, Italy
Mech Ageing Dev 129:759-62. 2008..Surprisingly, both diets counteracted the age-associated changes in plasma cholesterol and triglycerides similarly and benefits were already visible in adult rats... - Effects of life-long exercise on circulating free fatty acids and muscle triglyceride content in ageing ratsMichela Novelli
Dipartimento di Patologia Sperimentale, B.M.I.E, University of Pisa, Via Roma, 55-Scuola Medica, Pisa I-56126, Italy
Exp Gerontol 39:1333-40. 2004..Forced training or moderate food restriction appear slightly less effective than voluntary exercise in preventing age-dependent alterations in nutrient distribution and/or utilization... - Stimulation of autophagy by antilipolytic drugs may rescue rodents from age-associated hypercholesterolemiaSara Straniero
Centro di Ricerca di Biologia e Patologia dell Invecchiamento, Universita di Pisa, Pisa, Italy
Rejuvenation Res 12:77-84. 2009.... - Accumulation of dolichol in older tissues satisfies the proposed criteria to be qualified a biomarker of agingIlaria Parentini
Centro di Ricerca di Biologia e Patologia dell'Invecchiamento, Via Roma 55-Scuola Medica, 56126 Pisa, Italy
J Gerontol A Biol Sci Med Sci 60:39-43. 2005..In this article, we show applications to the study of host-graft interaction and detection of gender-related differences in biological age, and we discuss mechanism(s) of accumulation... - In vivo effect of an antilipolytic drug (3,5'-dimethylpyrazole) on autophagic proteolysis and autophagy-related gene expression in rat liverAlessio Donati
Centro di ricerca di Biologia e Patologia, dell Invecchiamento, dell Università di Pisa, Via Roma 55, 56126 Pisa, Italy
Biochem Biophys Res Commun 366:786-92. 2008..In conclusion, antilipolytic drugs may induce both autophagic proteolysis and higher expression of an autophagy-related gene and the effect on autophagy gene expression might not be secondary to the stimulation of autophagic proteolysis... - Dolichol levels in younger and older rat hearts heterotopically transplanted in younger recipientsGabriella Cavallini
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia e Epidemiologia, University of Pisa, Italy
Lipids 37:913-6. 2002..No changes in D were observed in recipients' tissues. It is concluded that dolichol is not redistributed via circulation from the transplanted heart to the tissues and liver of the younger recipient... - Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysisAlessandra Del Roso
, 56123, Pisa, Italy
Exp Gerontol 38:519-27. 2003..Data may support the hypothesis that ad libitum feeding accelerates the rate of ageing by raising insulin plasma levels and suppressing autophagy and membrane maintenance, and that calorie restriction may break this vicious circle... 
Science fact and the SENS agenda. What can we reasonably expect from ageing research?Huber Warner
Buck Institute for Age Research, Novato, CA, USA
EMBO Rep 6:1006-8. 2005- Insulin, food restriction and the extension of lifespan: the mechanism of longevityEttore Bergamini
Eur J Endocrinol 150:95. 2004 - Caloric restrictions affect some factors involved in age-related hypercholesterolemiaChiara Martini
Department of Biology, University of Rome Roma Tre, 446 Viale Marconi, 00146 Rome, Italy
J Cell Biochem 101:235-43. 2007.... - Mechanisms underlying the impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in aged rat liverValentina Pallottini
Department of Biology, University Roma Tre, Viale Marconi 446, 00146 Rome, Italy
Mech Ageing Dev 125:633-9. 2004..These findings support the hypothesis that a different arrangement of the HMG-CoA reductase membrane domain in aged rats is a cause of reductase deregulation... - Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemiaValentina Pallottini
Department of Biology, University of Rome Roma Tre, Viale Marconi 446, 00146 Rome, Italy
J Cell Biochem 98:1044-53. 2006..The SREBP-2 in particular seems to be committed in multiple way to gene transcription. The obtained data represent a good contribution to explain the age-related hypercholesterolemia... - Peripheral lymphocyte 8-OHdG levels correlate with age-associated increase of tissue oxidative DNA damage in Sprague-Dawley rats. Protective effects of caloric restrictionFederica I Wolf
Institute of General Pathology and Giovanni XXIII Cancer Research Center, School of Medicine, Catholic University of Sacred Heart, L go F Vito, 1 Rome, Italy
Exp Gerontol 40:181-8. 2005..Immunohistochemistry might be exploited as a rapid and simple techniques for measuring lymphocytes oxidative DNA damage in large scale studies... - Molecular mechanisms of calorie restriction's protection against age-related sclerosisElena Chiarpotto
Department of Clinical and Biological Sciences, University of Torino, Italy
IUBMB Life 58:695-702. 2006.... - Calorie restriction protects against age-related rat aorta sclerosisLaura Castello
Department of Clinical and Biological Sciences, University of Turin, Italy
FASEB J 19:1863-5. 2005..The protection exerted by CR against fibrosclerosis might be due to a decrease of oxidative stress, with consequent decreased MAPK activity and down-regulation of AP-1 activation and of TGFbeta1 expression and signaling... - Effects of dietary restriction on age-related changes in the phospholipid fatty acid composition of various rat tissuesIlaria Tamburini
Centro di Ricerca Interdipartimentale Biologia e Patologia dell'Invecchiamento, Pisa, Italy
Aging Clin Exp Res 16:425-31. 2004..CONCLUSIONS: Most age-related changes (that occurred in the rat liver, kidney and heart and were counteracted by the two different types of DR) may be involved in the mechanism of aging... - Age-related changes of cholesterol and dolichol biosynthesis in rat liverMaria Marino
Department of Biology, University Roma Tre, V le Marconi 446, 00146, Rome, Italy
Mech Ageing Dev 123:1183-9. 2002..In addition, the liver of aged rats maintains the capability to regulate its Chol content and to modify Chol delivery into the blood... - Low level dietary restriction retards age-related dolichol accumulationGabriella Cavallini
Aging Clin Exp Res 14:152-4. 2002 - Changes in dolichol and pentosidine levels in the age-mismatched heterotopically transplanted rat heartGabriella Cavallini
Department of Experimental Pathology, The University of Genova, Italy
Biogerontology 5:383-8. 2004.... - Age-related changes in endothelin-1 receptor subtypes in rat heartSilvia Del Ry
CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
Exp Aging Res 34:251-66. 2008..These findings indicate an alteration in ET-1 cardiac receptors associated with aging, mainly due to a variation in the receptor subtype distribution... - Autophagy and aging: the importance of maintaining "clean" cellsAna Maria Cuervo
Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Autophagy 1:131-40. 2005..Dietary caloric restriction and antilipolytic agents have been proven to efficiently stimulate autophagy in old rodents. These and other possible experimental restorative efforts are discussed... - 3-Hydroxy-3-methylglutaryl coenzyme A reductase deregulation and age-related hypercholesterolemia: a new role for ROSValentina Pallottini
Department of Biology, University of Roma Tre, Viale Marconi 446, 00146 Rome, Italy
Mech Ageing Dev 126:845-51. 2005..Thus, our data show full correlation between ROS production and increased HMGCoAR activity. The possible therapeutic implications of these results are discussed... - Age-related HMG-CoA reductase deregulation depends on ROS-induced p38 activationValentina Pallottini
Department of Biology, University of Rome Roma Tre, Viale Marconi 446, 00146 Rome, Italy
Mech Ageing Dev 128:688-95. 2007..Thus, in this work, we have performed a study of HMG-CoAR by analyzing the enzymes involved in its short-term regulation, namely, AMP-activated kinase (AMPK) and protein phosphatase 2A (PP2A)... - Dolichol: an essential part in the antioxidant machinery of cell membranes?Ettore Bergamini
Biogerontology 4:337-9. 2003 - In response to: "Is there an antiaging medicine?"Ettore Bergamini
J Gerontol A Biol Sci Med Sci 58:483. 2003 - Low-level caloric restriction rescues proteasome activity and Hsc70 level in liver of aged ratsMara A Bonelli
Sezione di Patologia Molecolare ed Immunologia, Dipartimento di Medicina Sperimentale, Universita degli Studi di Parma, Parma, Italy
Biogerontology 9:1-10. 2008..In conclusion, the results presented in this work show that a mild CR can have beneficial effects on liver function of aging rats because is adequate to counteract the decrease of proteasome function and Hsc70 chaperone level... - Effect of a caloric restriction regimen on the angiogenic capacity of aorta and on the expression of endothelin-1 during ageingFloriana Facchetti
Department of Biomolecular Science and Biotechnology, University of Milan, Italy
Exp Gerontol 42:662-7. 2007..Interestingly, the mRNA ET-1 levels as well as ET-1 expression in aorta sprouting decreases both in middle and in aged animals. Mild and severe caloric restriction regimens prevents ET-1 changes... - Effect of increasing age on tissue dolichol levels in ad libitum fed and food-restricted ratsGabriella Cavallini
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia e Epidemiologia. University of Pisa, Pisa, Italy
Biogerontology 4:341-5. 2003..In conclusion, these data show that the quantity of dolichol in the hepatic tissue might be used as a marker of the biological age of the animal... - Effects of oxidative stress on the Dolichol content of isolated rat liver cellsMonica Guarini
Centro di Ricerca Interdipartimentale di Biologia e Patologia dell Invecchiamento dell Università di Pisa, Italy
Free Radic Res 41:1283-8. 2007..In conclusion, an increase in oxidative stress possibly caused a rapid degradation of dolichol by the same (unknown) mechanism responsible for the breakdown of Ubiquinone isoprenoid chains...