Alfredo Berardelli

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. doi request reprint Consensus paper on short-interval intracortical inhibition and other transcranial magnetic stimulation intracortical paradigms in movement disorders
    Alfredo Berardelli
    Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Italy
    Brain Stimul 1:183-91. 2008
  2. doi request reprint Noninvasive brain stimulation in Huntington's disease
    Alfredo Berardelli
    Department of Neurology and Psychiatry Neuromedical Institute, Sapienza University of Rome, Rome, Italy Electronic address
    Handb Clin Neurol 116:555-60. 2013
  3. doi request reprint Facial bradykinesia
    Matteo Bologna
    Neuromed Institute IRCCS, Pozzilli Is, Italy
    J Neurol Neurosurg Psychiatry 84:681-5. 2013
  4. doi request reprint EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson's disease
    A Berardelli
    Dipartimento di Neurologia e Psichiatria and IRCCS NEUROMED Institute, Sapienza, Universita di Roma, Rome, Italy
    Eur J Neurol 20:16-34. 2013
  5. doi request reprint Pathophysiology of pain and fatigue in Parkinson's disease
    A Berardelli
    Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy
    Parkinsonism Relat Disord 18:S226-8. 2012
  6. ncbi request reprint Neurological research in Italy in 2003 and 2004
    A Berardelli
    Department of Neurological Sciences and Neuromed Institute, University of Rome La Sapienza, Rome, Italy
    Neurol Sci 26:189-93. 2005
  7. ncbi request reprint New advances in the pathophysiology of focal dystonias
    Alfredo Berardelli
    Department of Neurological Sciences and Neuromed Institute, University of Rome La Sapienza, Rome, Italy
    Brain 129:6-7. 2006
  8. ncbi request reprint Pathophysiology of tics and Tourette syndrome
    Alfredo Berardelli
    Dept of Neurological Sciences and Istituto Neurologico Mediterraneo, Neuromed IRCCS, Pozzilli IS University of Rome La Sapienza, Rome, Italy
    J Neurol 250:781-7. 2003
  9. doi request reprint Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinson's disease
    Antonella Conte
    Department of Neurological Sciences, Sapienza University of Rome, Viale dell Universita 30, Rome, Italy
    Brain 133:2656-63. 2010
  10. doi request reprint Abnormal cortical and brain stem plasticity in Gilles de la Tourette syndrome
    Antonio Suppa
    Neuromed Institute, Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy
    Mov Disord 26:1703-10. 2011

Detail Information

Publications109 found, 100 shown here

  1. doi request reprint Consensus paper on short-interval intracortical inhibition and other transcranial magnetic stimulation intracortical paradigms in movement disorders
    Alfredo Berardelli
    Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Italy
    Brain Stimul 1:183-91. 2008
    ..Results on short-interval intracortical inhibition (SICI), intracortical facilitation (ICF) and long-interval intracortical inhibition (LICI) are reported and discussed for each type of movement disorder...
  2. doi request reprint Noninvasive brain stimulation in Huntington's disease
    Alfredo Berardelli
    Department of Neurology and Psychiatry Neuromedical Institute, Sapienza University of Rome, Rome, Italy Electronic address
    Handb Clin Neurol 116:555-60. 2013
    ..Evidence from a single study of small cohorts of patients with HD supports the therapeutic application of rTMS for symptomatic improvement of chorea in HD. ..
  3. doi request reprint Facial bradykinesia
    Matteo Bologna
    Neuromed Institute IRCCS, Pozzilli Is, Italy
    J Neurol Neurosurg Psychiatry 84:681-5. 2013
    ..In PD, facial bradykinesia is primarily mediated by basal ganglia dysfunction whereas in PSP, facial bradykinesia is a consequence of a widespread degeneration involving the basal ganglia, cortical and brainstem structures...
  4. doi request reprint EFNS/MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson's disease
    A Berardelli
    Dipartimento di Neurologia e Psichiatria and IRCCS NEUROMED Institute, Sapienza, Universita di Roma, Rome, Italy
    Eur J Neurol 20:16-34. 2013
    ..A Task Force was convened by the EFNS/MDS-ES Scientist Panel on Parkinson's disease (PD) and other movement disorders to systemically review relevant publications on the diagnosis of PD...
  5. doi request reprint Pathophysiology of pain and fatigue in Parkinson's disease
    A Berardelli
    Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy
    Parkinsonism Relat Disord 18:S226-8. 2012
    ....
  6. ncbi request reprint Neurological research in Italy in 2003 and 2004
    A Berardelli
    Department of Neurological Sciences and Neuromed Institute, University of Rome La Sapienza, Rome, Italy
    Neurol Sci 26:189-93. 2005
    ..The findings show that Italian researchers' gained an overall 7% share of peer-reviewed articles. This percentage places Italy in fourth place immediately after the United States, Great Britain and Germany...
  7. ncbi request reprint New advances in the pathophysiology of focal dystonias
    Alfredo Berardelli
    Department of Neurological Sciences and Neuromed Institute, University of Rome La Sapienza, Rome, Italy
    Brain 129:6-7. 2006
  8. ncbi request reprint Pathophysiology of tics and Tourette syndrome
    Alfredo Berardelli
    Dept of Neurological Sciences and Istituto Neurologico Mediterraneo, Neuromed IRCCS, Pozzilli IS University of Rome La Sapienza, Rome, Italy
    J Neurol 250:781-7. 2003
    ..Dysfunction of basal ganglia-thalamo-cortical projections affects sensorimotor, language and limbic cortical circuits, and may explain why patients with Tourette syndrome have difficulty in inhibiting unwanted behaviors and impulses...
  9. doi request reprint Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinson's disease
    Antonella Conte
    Department of Neurological Sciences, Sapienza University of Rome, Viale dell Universita 30, Rome, Italy
    Brain 133:2656-63. 2010
    ..Deep brain stimulation degrades somatosensory temporal discrimination by modifying central somatosensory processing whereas dopamine restores the interplay between cortical and subcortical structures...
  10. doi request reprint Abnormal cortical and brain stem plasticity in Gilles de la Tourette syndrome
    Antonio Suppa
    Neuromed Institute, Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy
    Mov Disord 26:1703-10. 2011
    ....
  11. doi request reprint Onset and spread of dyskinesias and motor symptoms in Parkinson's disease
    Giovanni Fabbrini
    Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy
    Mov Disord 24:2091-6. 2009
    ..In this group, clinical examination yielded a significantly different distribution of LID and motor symptoms. These findings suggest that the onset and spread of LID and motor symptoms may follow different anatomical patterns...
  12. doi request reprint Voluntary, spontaneous, and reflex blinking in Parkinson's disease
    Rocco Agostino
    Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
    Mov Disord 23:669-75. 2008
    ..PD patients also display kinematic abnormalities of spontaneous blinking and changes in the excitability of the closing phase of reflex blinking...
  13. doi request reprint Ipsilateral sequential arm movements after unilateral subthalamic deep-brain stimulation in patients with Parkinson's disease
    Rocco Agostino
    Neuromed Institute, Sapienza, University of Rome, Italy
    Mov Disord 23:1718-24. 2008
    ..Ipsilateral changes can be explained by the observation that the output structures of the basal ganglia send large ipsilateral and less dense contralateral projections to the thalamus...
  14. doi request reprint Phasic voluntary movements reverse the aftereffects of subsequent theta-burst stimulation in humans
    Ennio Iezzi
    Department of Neurological Sciences, Neuromed Institute, Sapienza University of Rome, Viale dell Universita, 30, 00185 Rome, Italy
    J Neurophysiol 100:2070-6. 2008
    ..Peripheral electrical stimulation had no effect on iTBS-induced aftereffects. Repeated phasic finger movements interfere with TBS-induced aftereffects probably by modulating mechanisms of brain metaplasticity...
  15. ncbi request reprint Mirror movements in patients with Parkinson's disease
    Donatella Ottaviani
    Department of Neurological Sciences and Neuromed Institute IRCCS, La Sapienza University of Rome, Rome, Italy
    Mov Disord 23:253-8. 2008
    ..16, P < 0.01). The low frequency of MM in PD probably relates to the complex interactions between the pathophysiological mechanisms leading to parkinsonian signs and the mechanisms responsible for movement lateralization...
  16. doi request reprint Voluntary, spontaneous and reflex blinking in patients with clinically probable progressive supranuclear palsy
    Matteo Bologna
    Department of Neurological Sciences, Sapienza, University of Rome, Rome, Italy
    Brain 132:502-10. 2009
    ..Abnormal voluntary, spontaneous and reflex blinking in patients with PSP reflects the widespread cortical, subcortical and brainstem degeneration related to this disease...
  17. doi request reprint Abnormal cortical synaptic plasticity in primary motor area in progressive supranuclear palsy
    Antonella Conte
    Department of Neurology and Psychiatry Sapienza, University of Rome, Viale dell Universita, 30, 00185 Rome, Italy
    Cereb Cortex 22:693-700. 2012
    ..The iTBS-induced abnormal MEP facilitation in PSP persisted at 1-year follow-up. In conclusion, patients with PSP have abnormal M1 LTP/LTD-like plasticity. The enhanced LTP-like cortical synaptic plasticity parallels disease progression...
  18. doi request reprint Psychiatric disorders in adult-onset focal dystonia: a case-control study
    Giovanni Fabbrini
    Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy
    Mov Disord 25:459-65. 2010
    ..The most common psychiatric features in patients with CD and BPS are depressive disorders...
  19. ncbi request reprint Attention influences the excitability of cortical motor areas in healthy humans
    Antonella Conte
    Department of Neurological Sciences, University of Rome La Sapienza, Viale dell Universita, 30, 00185 Rome, Italy
    Exp Brain Res 182:109-17. 2007
    ..None of the attentional conditions elicited changes in the F wave. In healthy subjects attentional processes influence the size of the MEP facilitation elicited by high-frequency rTMS and do so through premotor-to-motor connections...
  20. doi request reprint Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia
    Daniele Belvisi
    Department of Neurology and Psychiatry, Sapienza University of Rome, Italy
    Exp Neurol 240:64-74. 2013
    ..In FHD, the degree of early motor learning correlated with patients' clinical features. We conclude that experimentally-induced (iTBS and PAS) and behaviorally-induced LTP-like plasticity are both altered in FHD...
  21. doi request reprint Theta-burst stimulation over primary motor cortex degrades early motor learning
    Ennio Iezzi
    Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
    Eur J Neurosci 31:585-92. 2010
    ..cTBS over M1 degrades practice-related improvement in motor performance and motor retention, but not motor consolidation of a voluntary finger movement...
  22. ncbi request reprint Short-term cortical plasticity in patients with dystonia: a study with repetitive transcranial magnetic stimulation
    Francesca Gilio
    Department of Neurological Sciences and Neuromed Institute IRCCS, University of Rome La Sapienza, Rome, Italy
    Mov Disord 22:1436-43. 2007
    ..We conclude that in patients with upper limb dystonia there is an abnormal recovery from MEP facilitation after suprathreshold 5 Hz-rTMS suggesting an abnormal pattern of short-term cortical plasticity...
  23. doi request reprint Effects of attention on inhibitory and facilitatory phenomena elicited by paired-pulse transcranial magnetic stimulation in healthy subjects
    Antonella Conte
    Department of Neurological Sciences, University of Rome Sapienza, Viale dell Universita, 30, 00185, Rome, Italy
    Exp Brain Res 186:393-9. 2008
    ....
  24. doi request reprint Psychopathological features of obsessive-compulsive disorder in an Italian family with Gilles de la Tourette syndrome not linked to the SLITRK1 gene
    Massimo Pasquini
    Department of Psychiatric Science and Psychological Medicine, Sapienza University of Rome, Rome, Italy
    Psychiatry Res 161:109-11. 2008
    ..Ten patients were found to have obsessive-compulsive disorder in which tic-like compulsions predominated. The distinctive feature of this family is the high frequency of obsessive-compulsive disorder with various clinical phenotypes...
  25. doi request reprint Psychiatric disorders in patients with essential tremor
    Giovanni Fabbrini
    Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy
    Parkinsonism Relat Disord 18:971-3. 2012
    ..Previous studies have reported that a consistent proportion of patients with Essential Tremor may have psychiatric disorders but it is unclear whether these disorders are increased in frequency as compared to healthy subjects...
  26. ncbi request reprint Plasticity of the motor cortex in Parkinson's disease patients on and off therapy
    Sergio Bagnato
    Department of Neurological Sciences, University of Rome La Sapienza, Rome, Italy
    Mov Disord 21:639-45. 2006
    ..After patients received dopaminergic therapy, these abnormalities normalized. The abnormal responsiveness of sensorimotor cortex neurons to PAS in PD patients off therapy probably reflects disordered plasticity within the motor cortex...
  27. doi request reprint Clinical, neuropsychological, neurophysiologic, and genetic features of a new Italian pedigree with familial cortical myoclonic tremor with epilepsy
    Antonio Suppa
    Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
    Epilepsia 50:1284-8. 2009
    ..Linkage analysis excluded the 8q24 locus, where patients shared a common haplotype spanning 14.5 Mb in the pericentromeric region of chromosome 2...
  28. doi request reprint Effects of intermittent theta-burst stimulation on practice-related changes in fast finger movements in healthy subjects
    Rocco Agostino
    Neuromed Institute IRCCS, Sapienza, University of Rome, Rome, Italy
    Eur J Neurosci 28:822-8. 2008
    ..We suggest that iTBS delivered over the primary motor cortex is insufficient to alter motor performance because early motor learning probably engages a wide cortical and subcortical network...
  29. ncbi request reprint The timing and intensity of transcranial magnetic stimulation, and the scalp site stimulated, as variables influencing motor sequence performance in healthy subjects
    Bruno Gregori
    Department of Neurological Sciences, University of Rome La Sapienza, Viale Università 30, 00185 Rome, Italy
    Exp Brain Res 166:43-55. 2005
    ..We investigated the effects of TMS delivered over various cortical motor areas during the reaction time (RT) on the execution of sequential rapid arm movements in healthy subjects...
  30. doi request reprint Correlation between cortical plasticity, motor learning and BDNF genotype in healthy subjects
    P Li Voti
    Department of Neurology and Psychiatry, Sapienza, University of Rome, Viale dell Universita 30, 00185, Rome, Italy
    Exp Brain Res 212:91-9. 2011
    ..Individual success in behavioural learning is unlikely to be closely related to any single measure of synaptic plasticity...
  31. ncbi request reprint Impairment of individual finger movements in patients with hand dystonia
    Antonio Curra
    Dipartimento di Scienze Neurologiche, Universita degli Studi di Roma La Sapienza, Rome, Italy
    Mov Disord 19:1351-7. 2004
    ..This finding reflects the finer cortical control needed to promote and sustain this highly fractionated type of motor output, and points toward underactivity of the primary motor cortex in dystonia...
  32. doi request reprint Somatosensory temporal discrimination tested in patients receiving botulinum toxin injection for cervical dystonia
    Alessandra Scontrini
    Department of Neurology and Psychiatry, Sapienza, University of Rome, Rome, Italy
    Mov Disord 26:742-6. 2011
    ..The lack of BTX-induced effects on STD thresholds suggests that STD recruits neural structures uninvolved in muscle spindle afferent activation...
  33. doi request reprint Pain as a nonmotor symptom of Parkinson disease: evidence from a case-control study
    Giovanni Defazio
    Department of Neurology and Psychiatry, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    Arch Neurol 65:1191-4. 2008
    ..To determine whether pain is more frequent among people with Parkinson disease (PD) than among age-matched controls...
  34. ncbi request reprint Prolonged practice is of scarce benefit in improving motor performance in Parkinson's disease
    Rocco Agostino
    Istituto Neurologico Mediterraneo Neuromed IRCCS, Universita di Roma La Sapienza, Rome, Italy
    Mov Disord 19:1285-93. 2004
    ..Our study may be relevant for planning and executing rehabilitation programs in these patients...
  35. doi request reprint Short-term and long-term plasticity interaction in human primary motor cortex
    Ennio Iezzi
    Neuromed Institute, Sapienza University of Rome, Viale dell Universita, 30 00185 Rome, Italy
    Eur J Neurosci 33:1908-15. 2011
    ..Our study provides new information on interactions between short-term and long-term rTMS-induced plasticity in human M1...
  36. ncbi request reprint Dual dopamine agonist treatment in Parkinson's disease
    Fabrizio Stocchi
    Department of Neurological Sciences, IRCCS NEUROMED POZZILLI IS, Viale dell Universita 30, 00185, Rome, Italy
    J Neurol 250:822-6. 2003
    ..5+/-5.3 to 15.5+/-4.7). This open study shows that dual dopamine agonist therapy can be useful in the symptomatic treatment of patients with early or more advanced Parkinson's disease receiving therapy with or without levodopa...
  37. doi request reprint Primary somatosensory cortical plasticity and tactile temporal discrimination in focal hand dystonia
    Antonella Conte
    IRCCS Neuromed, Via Atinense 18, 86077 Pozzilli, Italy Department of Neurology and Psychiatry, Sapienza University of Rome, Viale dell Universita 30, 00185 Rome, Italy
    Clin Neurophysiol 125:537-43. 2014
    ..To investigate whether theta burst stimulation (TBS) applied over primary somatosensory cortex (S1) modulates somatosensory temporal discrimination threshold (STDT) and writing performances in patients with focal hand dystonia (FHD)...
  38. doi request reprint Poor self-awareness of levodopa-induced dyskinesias in Parkinson's disease: clinical features and mechanisms
    Sara Pietracupa
    Department of Neurology and Psychiatry, Sapienza University of Rome, Italy
    Parkinsonism Relat Disord 19:1004-8. 2013
    ..To study the factors and possible mechanisms associated with decreased self-awareness of levodopa-induced dyskinesias (LIDs) in patients with Parkinson's disease (PD)...
  39. ncbi request reprint Impairment of individual finger movements in Parkinson's disease
    Rocco Agostino
    Dipartimento di Scienze Neurologiche, Universita di Roma La Sapienza, Rome, Italy
    Mov Disord 18:560-5. 2003
    ..Parkinson's disease, therefore, impairs individual finger movements more than gross hand movements. This distinction reflects the finer cortical control needed to promote and sustain this highly fractionated type of motor output...
  40. pmc Is increased blinking a form of blepharospasm?
    Antonella Conte
    Department of Neurology and Psychiatry, Sapienza University of Rome, Italy
    Neurology 80:2236-41. 2013
    ..The aim of this study was to investigate whether increased blink rate (BR) is part of the clinical spectrum of primary blepharospasm (BSP)...
  41. ncbi request reprint A large Italian family with Gilles de la Tourette syndrome: clinical study and analysis of the SLITRK1 gene
    Giovanni Fabbrini
    Department of Neurological Sciences and Neuromed Institute, University La Sapienza, Rome, Italy
    Mov Disord 22:2229-34. 2007
    ..The negative results of the SLITRK1 analysis point to genetic heterogeneity in TS...
  42. doi request reprint Cranial movement disorders: clinical features, pathophysiology, differential diagnosis and treatment
    Giovanni Fabbrini
    Movement Disorders Clinic, Department of Neurosciences and Neuromed Institute, Sapienza University of Rome, Rome
    Nat Clin Pract Neurol 5:93-105. 2009
    ..Here, we review the clinical features, pathophysiologies and therapies of the main movement disorders that affect the face, jaw, tongue and palate...
  43. doi request reprint Soluble and controlled-release preparations of levodopa: do we really need them?
    Giovanni Fabbrini
    Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
    J Neurol 257:S292-7. 2010
    ..New dual formulations incorporating both a faster absorption and an increased half-life than standard levodopa are currently under study...
  44. ncbi request reprint A novel family with an unusual early-onset generalized dystonia
    Giovanni Fabbrini
    Department of Neurological Sciences, University La Sapienza, Rome, Italy
    Mov Disord 20:81-6. 2005
    ..The condition we describe could be a newly recognized dystonia syndrome with parkinsonism...
  45. ncbi request reprint Fast voluntary neck movements in patients with cervical dystonia: a kinematic study before and after therapy with botulinum toxin type A
    B Gregori
    Department of Neurological Sciences, University of Rome La Sapienza, Viale dell Universita, 30, 00185 Rome, Italy
    Clin Neurophysiol 119:273-80. 2008
    ..To study fast voluntary neck movements in patients with cervical dystonia (CD) before and after therapy with botulinum toxin type-A (BTX-A)...
  46. ncbi request reprint Acute and chronic effects of ethanol on cortical excitability
    A Conte
    Department of Neurological Sciences, University of Rome Sapienza, Viale dell Universita, 30, 00185, Rome, Italy
    Clin Neurophysiol 119:667-74. 2008
    ..We designed this study to find out whether 5Hz repetitive transcranial magnetic stimulation (rTMS) would disclose changes in cortical plasticity after acute intake of ethanol and in patients with chronic alcohol consumption...
  47. ncbi request reprint Effects of 5 Hz subthreshold magnetic stimulation of primary motor cortex on fast finger movements in normal subjects
    R Agostino
    Department of Neurological Sciences and Neuromed Institute, University of Rome La Sapienza, Viale dell Universita, 30, 00185 Rome, Italy
    Exp Brain Res 180:105-11. 2007
    ..Since motor behaviour engages a distributed cortical and subcortical neuronal network, excitatory conditioning of the primary motor cortex is probably not sufficient to influence the behavioural output...
  48. doi request reprint Extrarolandic electroclinical findings in the evolution of adult-onset Rasmussen's encephalitis
    Sara Casciato
    Epilepsy Unit, Department of Neurology and Psychiatry, Sapienza University, Rome, Italy
    Epilepsy Behav 28:467-73. 2013
    ....
  49. doi request reprint Effect of camptocormia on lung volumes in Parkinson's disease
    Paolo Marinelli
    Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy
    Respir Physiol Neurobiol 187:164-6. 2013
    ..45° and supine) measurement of arterial oxygen-hemoglobin saturation and heart rate. We found that Parkinson's disease with camptocormia is not associated with major clinical changes in lung volumes...
  50. ncbi request reprint A comparative study of primary and secondary hemifacial spasm
    Carlo Colosimo
    Department of Neurosciences and Neuromed Institute, University of Rome La Sapienza, Rome, Italy
    Arch Neurol 63:441-4. 2006
    ..Hemifacial spasm (HFS) is a common movement disorder...
  51. doi request reprint Do the unintended actions of botulinum toxin at distant sites have clinical implications?
    Antonio Curra
    Department of Neurological Sciences and A Fiorini Hospital, Terracina, LT, Sapienza, University of Rome, Polo Pontino, Italy
    Neurology 72:1095-9. 2009
    ..Whatever the mechanism, the lack of deleterious central effects implies that while research into action mechanisms continues, physicians can safely use BT for therapy...
  52. ncbi request reprint Repetitive magnetic stimulation of cortical motor areas in Parkinson's disease: implications for the pathophysiology of cortical function
    F Gilio
    Dipartimento Scienze Neurologiche, Universita di Roma La Sapienza, Rome, Italy
    Mov Disord 17:467-73. 2002
    ..The reduced rTMS-induced facilitation of MEPs in patients with Parkinson's disease reflects a decreased facilitation of the excitatory cells in the cortical motor areas...
  53. ncbi request reprint Effects of repetitive transcranial magnetic stimulation on spike-and-wave discharges
    Antonella Conte
    Department of Neurological Sciences, University of Rome La Sapienza, Rome, Italy
    Neurosci Res 57:140-2. 2007
    ..Despite the limitations of a single case report, our neurophysiological findings suggest that 5Hz-suprathreshold rTMS delivered in short trains induces a transitory interference of the ongoing epileptic activity...
  54. doi request reprint No association between essential tremor and migraine: a case-control study
    Piero Barbanti
    Headache and Pain Unit, Department of Neurological, Motor and Sensorial Sciences, IRCCS San Raffaele Pisana, Rome, Italy
    Cephalalgia 30:686-9. 2010
    ..Our study excludes a comorbid association between ET and migraine. When ET and migraine coexist their clinical phenotype and evolution remain almost unchanged...
  55. ncbi request reprint Pathophysiology and treatment of cranial dystonia
    Alfredo Berardelli
    Department of Neurological Sciences, University of Rome La Sapienza and Istituto Neurologico Mediterraneo Neuromed, IRCCS, Pozzilli, Italy
    Mov Disord 17:S70-4. 2002
  56. ncbi request reprint Recent findings in cranial and cervical dystonia: how they help us to understand the pathophysiology of dystonia
    Antonio Curra
    Dipartimento di Scienze Neurologiche, Universita degli Studi di Roma La Sapienza, 00185 Rome, Italy
    Suppl Clin Neurophysiol 58:257-65. 2006
  57. ncbi request reprint Drug Insight: new drugs in development for Parkinson's disease
    Carlo Colosimo
    University Department of Neurosciences University of Rome, La Sapienza, Italy
    Nat Clin Pract Neurol 2:600-10. 2006
    ..In this Review, we discuss the numerous drugs in development that target the primary motor disorder in Parkinson's disease...
  58. ncbi request reprint Antiepileptic drugs and cortical excitability: a study with repetitive transcranial stimulation
    M Inghilleri
    Department of Neurological Sciences, Viale dell Universita 30, 00185, Rome, Italy
    Exp Brain Res 154:488-93. 2004
    ..Our results suggest that carbamazepine, gabapentin and topiramate modulate intracortical excitability by acting selectively on excitatory interneurons...
  59. ncbi request reprint Synaptic potentiation induced by rTMS: effect of lidocaine infusion
    M Inghilleri
    Department of Neurological Sciences, University of Rome La Sapienza, Viale dell Universita, 30, 00185 Rome, Italy
    Exp Brain Res 163:114-7. 2005
    ..Our results suggest that the MEP facilitation related to rTMS-induced synaptic potentiation results from an increase in cortical excitatory interneuron excitability that involves voltage-gated sodium channels...
  60. ncbi request reprint Headache in cranial and cervical dystonia
    P Barbanti
    Department of Neurosciences, University La Sapienza, Rome, Italy
    Neurology 64:1308-9. 2005
  61. ncbi request reprint Ovarian hormones and cortical excitability. An rTMS study in humans
    M Inghilleri
    Department of Neurological Sciences, University of Rome La Sapienza, Viale dell Universita 30, 00185 Rome, Italy
    Clin Neurophysiol 115:1063-8. 2004
    ..Ovarian steroids influence neural excitability. Using repetitive transcranial magnetic stimulation (rTMS) we investigated changes in cortical excitability during the menstrual cycle...
  62. doi request reprint Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study
    Carlo Colosimo
    Dipartimento di Scienze Neurologiche, Sapienza Universita di Roma, Rome, Italy
    J Neurol 257:5-14. 2010
    ..Atypical parkinsonism patients also reported a low QoL, with no significant differences among the different forms, whereas PD and VP patients had a better QoL...
  63. doi request reprint A transverse and longitudinal MR imaging voxel-based morphometry study in patients with primary cervical dystonia
    P Pantano
    Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
    AJNR Am J Neuroradiol 32:81-4. 2011
    ..Our purpose was to evaluate GM volumes in patients with CD at baseline and 5 years later...
  64. pmc Diffusion tensor imaging in primary cervical dystonia
    C Colosimo
    Department of Neurological Sciences, University La Sapienza, I 00185 Rome, Italy
    J Neurol Neurosurg Psychiatry 76:1591-3. 2005
    ..It is the traditional view that primary dystonia arises from abnormal basal ganglia function but causes no apparent morphological changes...
  65. ncbi request reprint Topiramate and cortical excitability in humans: a study with repetitive transcranial magnetic stimulation
    M Inghilleri
    Dipartimento Scienze Neurologiche, Universita di Roma La Sapienza, Rome, Italy
    Exp Brain Res 174:667-72. 2006
    ....
  66. ncbi request reprint Altered response to rTMS in patients with Alzheimer's disease
    M Inghilleri
    Department of Neurological Sciences, University of Rome La Sapienza, Viale dell Universita, 30, 00185 Rome, Italy
    Clin Neurophysiol 117:103-9. 2006
    ....
  67. doi request reprint Clinical phenomenology of dystonia
    Carlo Colosimo
    Department of Neurology and Psychiatry and Neuromed Institute IRCSS, Sapienza University of Rome, Italy
    Int Rev Neurobiol 98:509-24. 2011
    ..The different subtypes of focal and segmental dystonias may have different clinical features. Neuropsychiatric disorders may be present in dystonia...
  68. ncbi request reprint Excitatory and inhibitory after-effects after repetitive magnetic transcranial stimulation (rTMS) in normal subjects
    F Gilio
    Dipartimento Scienze Neurologiche, Universita di Roma La Sapienza, Viale dell Universita, 30, 00185, Rome, Italy
    Exp Brain Res 176:588-93. 2007
    ..rTMS probably elicits its after-effects on excitatory and inhibitory cortical elements through different physiological mechanisms...
  69. ncbi request reprint Effects of transcranial magnetic stimulation on the H reflex and F wave in the hand muscles
    M Inghilleri
    Dipartimento Scienze Neurologiche, Universita di Roma La Sapienza, Viale Universita, 30, 00185, Rome, Italy
    Clin Neurophysiol 114:1096-101. 2003
    ..In 14 healthy subjects, we studied the effects of transcranial magnetic stimulation (TMS) on the excitability of spinal motoneurons in the abductor pollicis brevis muscle (ABP), by testing the F wave and H reflex...
  70. doi request reprint The neurobiology of falls
    Alfonso Fasano
    Department of Neurology, Catholic University, Rome, Italy
    Neurol Sci 33:1215-23. 2012
    ..This translational approach will lead to the development of specific therapeutic interventions...
  71. pmc Development and validation of a clinical guideline for diagnosing blepharospasm
    Giovanni Defazio
    Department of Basic Medical Sciences, Neurosciences and Sense organs, Aldo Moro University of Bari, Italy
    Neurology 81:236-40. 2013
    ..To design and validate a clinical diagnostic guideline for aiding physicians in confirming or refuting suspected blepharospasm...
  72. ncbi request reprint Efficacy and safety of long-term botulinum toxin treatment in craniocervical dystonia: a systematic review
    Carlo Colosimo
    Dipartimento di Neurologia e Psichiatria, Sapienza Universita di Roma, Viale dell Universita 30, 00185 Rome, Italy
    Neurotox Res 22:265-73. 2012
    ..Longitudinal studies aimed at defining the risk factors for this abnormal pattern of response to botulinum toxin treatment are currently being conducted...
  73. doi request reprint An early image of hemifacial spasm: Edouard Brissaud contribution
    Carlo Colosimo
    Department of Neurological Sciences and Neuromed Institute, Sapienza University of Rome, Rome, Italy
    Mov Disord 25:531-3. 2010
    ..We also discuss the role of other early European authors (Schültze, Gowers, Babinski, and Negro) who contributed to the definition of hemifacial spasm in the late 19th and early 20th centuries...
  74. ncbi request reprint Apomorphine infusion and the long-duration response to levodopa in advanced Parkinson's disease
    Fabrizio Stocchi
    Institute of Neurology IRCCS NEUROMED, Pozzilli, Rome, Italy
    Clin Neuropharmacol 26:151-5. 2003
    ..This effect is probably the result of postsynaptic mechanisms. In patients with advanced Parkinson's disease, the long-duration response to levodopa is present although slightly diminished...
  75. doi request reprint Autonomic cardiovascular function and baroreflex sensitivity in patients with cervical dystonia receiving treatment with botulinum toxin type A
    D Tiple
    Department of Neurological Sciences and Neuromed Institute IRCCS, University of Rome La Sapienza, Viale dell Universita, 30, 00185 Roma, Italy
    J Neurol 255:843-7. 2008
    ..To investigate possible changes in autonomic cardiovascular regulation and cardiopulmonary baroreflex sensitivity in patients with primary cervical dystonia receiving chronic treatment with botulinum toxin type A...
  76. ncbi request reprint No clinical or neurophysiological evidence of botulinum toxin diffusion to non-injected muscles in patients with hemifacial spasm
    C Lorenzano
    Department of Neurosciences and Institute Neuromed IRCCS, University of Rome La Sapienza, Roma, Italy
    Neurotox Res 9:141-4. 2006
    ....
  77. pmc Role of the dopamine D5 receptor (DRD5) as a susceptibility gene for cervical dystonia
    F Brancati
    Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
    J Neurol Neurosurg Psychiatry 74:665-6. 2003
    ..These results provide further evidence of an association between DRD5 and cervical dystonia, supporting the involvement of the dopamine pathway in the pathogenesis of CD...
  78. doi request reprint Diffusion tensor imaging in patients with primary cervical dystonia and in patients with blepharospasm
    G Fabbrini
    Department of Neurological Sciences and Neuromed Institute IRCCS, La Sapienza University of Rome, Rome, Italy
    Eur J Neurol 15:185-9. 2008
    ..The abnormal DTI findings in patients with CD suggest the presence of brain ultrastructural changes in adult-onset primary CD...
  79. ncbi request reprint Abnormalities of motor cortex excitability preceding movement in patients with dystonia
    F Gilio
    Department of Neurological Sciences, University of Rome La Sapienza, Viale Università 30, 00185 Rome, Italy
    Brain 126:1745-54. 2003
    ..In conclusion, these findings from reaction time tasks in patients with primary dystonia provide evidence of abnormal pre-movement motor cortex excitability. This abnormality is due to an altered release or running of motor programmes...
  80. doi request reprint Electrical activation of the orbicularis oculi muscle does not increase the effectiveness of botulinum toxin type A in patients with blepharospasm
    A Conte
    Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
    Eur J Neurol 17:449-55. 2010
    ..The second aim was to assess the safety of BonT-A by investigating whether BonT-A injection alters the excitability of blink reflex circuits in the brainstem...
  81. ncbi request reprint Is the cutaneous silent period an opiate-sensitive nociceptive reflex?
    Maurizio Inghilleri
    Department of Neurological Sciences, University of Rome La Sapienza, Viale dell Universita 30, 00185 Rome, Italy
    Muscle Nerve 25:695-9. 2002
    ....
  82. ncbi request reprint The prolonged cortical silent period in patients with Huntington's disease
    N Modugno
    Dipartimento di Scienze Neurologiche, , , 00185, Rome, Italy
    Clin Neurophysiol 112:1470-4. 2001
    ..We suggest that the prolonged SP in HD originates from a dysfunction of the mechanisms controlling the restart of voluntary movement after TMS...
  83. ncbi request reprint Bladder filling inhibits somatic spinal motoneurones
    M Inghilleri
    Dipartimento di Scienze Neurologiche, , 00185, Rome, Italy
    Clin Neurophysiol 112:2255-60. 2001
    ..This vesical-induced inhibition is probably mediated by the propriospinal system rather than by the diffuse noxious inhibitory control circuit...
  84. ncbi request reprint Novel Italian family supports clinical and genetic heterogeneity of primary adult-onset torsion dystonia
    Francesco Brancati
    Istituto C S S Mendel, Rome, Italy
    Mov Disord 17:392-7. 2002
    ..These findings support genetic heterogeneity of PTD and indicate that a novel unassigned gene is responsible for focal dystonia in this family...
  85. doi request reprint Craniocervical dystonia: clinical and pathophysiological features
    C Colosimo
    Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy
    Eur J Neurol 17:15-21. 2010
    ..The best treatment for craniocervical dystonia is botulinum toxin injected into the overactive muscles...
  86. doi request reprint Status epilepticus in epileptic patients. Related syndromes, precipitating factors, treatment and outcome in a video-EEG population-based study
    C Di Bonaventura
    Department of Neurological Sciences, Policlinico Umberto I degrees, University of Rome La Sapienza, Italy
    Seizure 17:535-48. 2008
    ..Status epilepticus (SE) is frequently observed in epileptic patients. We reviewed a series of video-EEG documented SE to define the characteristics of SE in this population...
  87. doi request reprint Somatosensory temporal discrimination in patients with primary focal dystonia
    A Scontrini
    Department of Neurological Sciences, Sapienza, University of Rome, Rome, Italy
    J Neurol Neurosurg Psychiatry 80:1315-9. 2009
    ..To determine whether somatosensory temporal discrimination will reliably detect subclinical sensory impairment in patients with various forms of primary focal dystonia...
  88. ncbi request reprint Motor cortical excitability studied with repetitive transcranial magnetic stimulation in patients with Huntington's disease
    C Lorenzano
    Department of Neurological Sciences, University of Rome La Sapienza, Rome, Italy
    Clin Neurophysiol 117:1677-81. 2006
    ..TMS techniques have provided controversial information on motor cortical function in Huntington's disease (HD). We investigated the excitability of motor cortex in patients with HD using repetitive transcranial magnetic stimulation (rTMS)...
  89. ncbi request reprint Corticospinal excitability during motor imagery of a simple tonic finger movement in patients with writer's cramp
    Angelo Quartarone
    Department of Neurosciences, Psychiatric and Anaesthesiological Sciences, University of Messina, Italy
    Mov Disord 20:1488-95. 2005
    ..This abnormal spread of facilitation was observed in the affected and unaffected upper limb. MI of simple hand movements is less efficient and less focussed in patients with writer's cramp than it is in normal subjects...
  90. ncbi request reprint Task-specific impairment of motor cortical excitation and inhibition in patients with writer's cramp
    Michele Tinazzi
    Unita Operativa di Neurologia, Ospedale Civile Borgo Trento, Piazzale Stefani 1, 37100 Verona, Italy
    Neurosci Lett 378:55-8. 2005
    ..These results indicate a task-specific impairment of motor cortical excitation and inhibition in writer's cramp...
  91. ncbi request reprint Abnormal cortical and spinal inhibition in paroxysmal kinesigenic dyskinesia
    Pablo Mir
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Brain 128:291-9. 2005
    ....
  92. ncbi request reprint Sensorimotor integration in movement disorders
    Giovanni Abbruzzese
    Dipartimento di Scienze Neurologiche e della Visione, Universita di Genova, Via de Tony 5, 16132 Genoa, Italy
    Mov Disord 18:231-40. 2003
    ..Although the physiological mechanism remains unclear, the defect is of special clinical relevance in determining the development of focal dystonia...
  93. pmc Update on blepharospasm: report from the BEBRF International Workshop
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, 10 Center Drive MSC 1428, Bethesda, MD 20892 1428, USA
    Neurology 71:1275-82. 2008
    ..Physiologic studies indicate increased plasticity and trigeminal sensitization. While botulinum neurotoxin injections are the mainstay of therapy, other therapies are on the horizon...
  94. ncbi request reprint Are nongenetic triggers for dystonia type-specific? A study exploring scoliosis in blepharospasm
    Davide Martino
    Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy
    Mov Disord 22:576-8. 2007
    ..The frequency of scoliosis did not differ between blepharospasm patients and controls. This finding supports the hypothesis that environmental risk factors may be specific for a single form of adult-onset dystonia...
  95. ncbi request reprint Do primary adult-onset focal dystonias share aetiological factors?
    Giovanni Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, Bari, Italy
    Brain 130:1183-93. 2007
    ....
  96. ncbi request reprint Assessing the role of DRD5 and DYT1 in two different case-control series with primary blepharospasm
    Jordi Clarimon
    Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    Mov Disord 22:162-6. 2007
    ..These data suggest that further examination is warranted of the role genetic variability at this locus plays in the risk for primary dystonia...
  97. ncbi request reprint Planning genetic studies on primary adult-onset dystonia: sample size estimates based on examination of first-degree relatives
    Giovanni Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, Bari, Italy
    J Neurol Sci 251:29-34. 2006
    ..These sample size estimates suggest that the S-TDT may be feasible, whereas collection of cases for both TDT and ASP approaches would represent a major collaborative challenge...
  98. ncbi request reprint Botulinum toxin changes intrafusal feedback in dystonia: a study with the tonic vibration reflex
    Carlo Trompetto
    Dipartimento di Neuroscienze, Oftalmologia e Genetica, Universita di Genova, Italia
    Mov Disord 21:777-82. 2006
    ..The action on intrafusal fibers could alter sensorimotor integration, thus contributing to the clinical benefits of BT-A injection...
  99. ncbi request reprint Neurophysiological investigations in patients with primary writing tremor
    Nicola Modugno
    Dipartimento di Scienze Neurologiche, Universita di Roma La Sapienza, Roma, and Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy
    Mov Disord 17:1336-40. 2002
    ..Our study suggests that the pathophysiology of PWT is different from that of writer's cramp and partially also from that of essential tremor...
  100. ncbi request reprint Epidemiology of primary dystonia
    Giovanni Defazio
    Department of Neurological and Psychiatric Sciences, University of Bari, Italy
    Lancet Neurol 3:673-8. 2004
    ....
  101. ncbi request reprint Central effects of botulinum toxin type A: evidence and supposition
    Antonio Curra
    Dipartimento di Scienze Neurologiche and Istituto Neurologico Mediterraneo Neuromed IRCCS, Universita degli Studi di Roma La Sapienza, Italia
    Mov Disord 19:S60-4. 2004
    ..The BT-A-induced reduction in spindle signals could, therefore, alter the balance between afferent input and motor output, thereby changing cortical excitability...