F Benedetti

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi request reprint Expectation modulates the response to subthalamic nucleus stimulation in Parkinsonian patients
    Antonella Pollo
    Department of Neuroscience, University of Turin Medical School, Corso Rafaello 30, 10125 Turin Italy
    Neuroreport 13:1383-6. 2002
  2. ncbi request reprint Loss of expectation-related mechanisms in Alzheimer's disease makes analgesic therapies less effective
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Turin, Italy
    Pain 121:133-44. 2006
  3. ncbi request reprint How prior experience shapes placebo analgesia
    Luana Colloca
    Department of Neuroscience, Clinical and Applied Physiology Program, University of Turin Medical School, Turin, Italy
    Pain 124:126-33. 2006
  4. doi request reprint Ask the Experts: Is there a place for placebo analgesia in everyday clinical practice?
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School and National Institute of Neuroscience, Corso Raffaello 30, 10125 Turin, Italy
    Pain Manag 1:211-2. 2011
  5. doi request reprint Placebo and the new physiology of the doctor-patient relationship
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, and National Institute of Neuroscience, Turin, Italy
    Physiol Rev 93:1207-46. 2013
  6. doi request reprint Mechanisms of the placebo response
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Turin, Italy National Institute of Neuroscience, Turin, Italy
    Pulm Pharmacol Ther 26:520-3. 2013
  7. doi request reprint Pain as a reward: changing the meaning of pain from negative to positive co-activates opioid and cannabinoid systems
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Turin, Italy
    Pain 154:361-7. 2013
  8. doi request reprint Placebo-induced improvements: how therapeutic rituals affect the patient's brain
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Turin, Italy
    J Acupunct Meridian Stud 5:97-103. 2012
  9. doi request reprint Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School and National Institute of Neuroscience INN, Turin, Italy
    Nat Med 17:1228-30. 2011
  10. doi request reprint Disruption of opioid-induced placebo responses by activation of cholecystokinin type-2 receptors
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School and National Institute of Neuroscience INN, Turin, Italy
    Psychopharmacology (Berl) 213:791-7. 2011

Detail Information

Publications61

  1. ncbi request reprint Expectation modulates the response to subthalamic nucleus stimulation in Parkinsonian patients
    Antonella Pollo
    Department of Neuroscience, University of Turin Medical School, Corso Rafaello 30, 10125 Turin Italy
    Neuroreport 13:1383-6. 2002
    ..All these effects occurred within minutes, suggesting that expectations induce neural changes very quickly...
  2. ncbi request reprint Loss of expectation-related mechanisms in Alzheimer's disease makes analgesic therapies less effective
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Turin, Italy
    Pain 121:133-44. 2006
    ....
  3. ncbi request reprint How prior experience shapes placebo analgesia
    Luana Colloca
    Department of Neuroscience, Clinical and Applied Physiology Program, University of Turin Medical School, Turin, Italy
    Pain 124:126-33. 2006
    ..These results emphasize that the placebo effect is a learning phenomenon in which many factors come into play, and may explain the large variability of the placebo responses that is found in many studies...
  4. doi request reprint Ask the Experts: Is there a place for placebo analgesia in everyday clinical practice?
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School and National Institute of Neuroscience, Corso Raffaello 30, 10125 Turin, Italy
    Pain Manag 1:211-2. 2011
    ..He is author of the book Placebo Effects (Oxford University Press, Oxford, UK, 2008), which received the Highly Commended Book Award of the British Medical Association, and The Patient's Brain (Oxford University Press 2010). ..
  5. doi request reprint Placebo and the new physiology of the doctor-patient relationship
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, and National Institute of Neuroscience, Turin, Italy
    Physiol Rev 93:1207-46. 2013
    ....
  6. doi request reprint Mechanisms of the placebo response
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Turin, Italy National Institute of Neuroscience, Turin, Italy
    Pulm Pharmacol Ther 26:520-3. 2013
    ....
  7. doi request reprint Pain as a reward: changing the meaning of pain from negative to positive co-activates opioid and cannabinoid systems
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Turin, Italy
    Pain 154:361-7. 2013
    ..Therefore, the behavioral and/or pharmacological manipulation of the meaning of pain can represent an effective approach to pain management...
  8. doi request reprint Placebo-induced improvements: how therapeutic rituals affect the patient's brain
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Turin, Italy
    J Acupunct Meridian Stud 5:97-103. 2012
    ..This new way of thinking may have profound implications in clinical trials and medical practice both for pharmacological interventions and for nonpharmacological treatments such as acupuncture...
  9. doi request reprint Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptors
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School and National Institute of Neuroscience INN, Turin, Italy
    Nat Med 17:1228-30. 2011
    ..These findings suggest that the endocannabinoid system has a pivotal role in placebo analgesia in some circumstances when the opioid system is not involved...
  10. doi request reprint Disruption of opioid-induced placebo responses by activation of cholecystokinin type-2 receptors
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School and National Institute of Neuroscience INN, Turin, Italy
    Psychopharmacology (Berl) 213:791-7. 2011
    ..Placebos are known to induce analgesia through the activation of μ-opioid receptors in some circumstances, such as after morphine pre-conditioning, an effect that is blocked by opioid antagonists...
  11. pmc How placebos change the patient's brain
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Turin, Italy
    Neuropsychopharmacology 36:339-54. 2011
    ..Third, if prefrontal functioning is impaired, placebo responses are reduced or totally lacking, as occurs in dementia of the Alzheimer's type...
  12. ncbi request reprint The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, 10125 Turin, Italy
    J Neurosci 26:12014-22. 2006
    ....
  13. pmc Electrophysiological properties of thalamic, subthalamic and nigral neurons during the anti-parkinsonian placebo response
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Turin, Italy
    J Physiol 587:3869-83. 2009
    ....
  14. ncbi request reprint Opioid-mediated placebo responses boost pain endurance and physical performance: is it doping in sport competitions?
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, and National Institute of Neuroscience, 10125 Turin, Italy
    J Neurosci 27:11934-9. 2007
    ....
  15. ncbi request reprint Placebo analgesia
    F Benedetti
    Department of Neuroscience, University of Turin Medical School, Corso Raffaello 30, I 10125, Turin, Italy
    Neurol Sci 27:S100-2. 2006
    ....
  16. ncbi request reprint Mechanisms of placebo and placebo-related effects across diseases and treatments
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, and National Institute of Neuroscience, Turin, Italy
    Annu Rev Pharmacol Toxicol 48:33-60. 2008
    ..This recent research has revealed that these psychosocial-induced biochemical changes in a patient's brain and body in turn may affect the course of a disease and the response to a therapy...
  17. ncbi request reprint When words are painful: unraveling the mechanisms of the nocebo effect
    F Benedetti
    Department of Neuroscience, University of Turin Medical School, Corso Raffaello 30, 10125 Turin, Italy
    Neuroscience 147:260-71. 2007
    ....
  18. ncbi request reprint Pain reactivity in Alzheimer patients with different degrees of cognitive impairment and brain electrical activity deterioration
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Corso Raffaello 30, 10125 Turin, Italy
    Pain 111:22-9. 2004
    ..This sensory-affective dissociation is well correlated with the neuropathological findings in AD...
  19. ncbi request reprint Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus
    Fabrizio Benedetti
    Department of Neuroscience, Clinical and Applied Physiology Program, University of Turin Medical School, Corso Raffaello 30, 10125 Turin, Italy
    Nat Neurosci 7:587-8. 2004
    ..These changes in activity were tightly correlated with clinical improvement; no decrease in activity occurred when the clinical placebo response was absent...
  20. ncbi request reprint Autonomic and emotional responses to open and hidden stimulations of the human subthalamic region
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Italy
    Brain Res Bull 63:203-11. 2004
    ..The difference between the open and hidden stimulations in the ventral subthalamic region can explain previous studies in which open and hidden stimulations produced different therapeutic outcomes...
  21. doi request reprint Hidden administration of drugs
    F Benedetti
    Department of Neuroscience, University of Turin Medical School, Turin, Italy
    Clin Pharmacol Ther 90:651-61. 2011
    ..This experimental approach is thus a window into the complex interactions between psychology and pharmacodynamics...
  22. ncbi request reprint Conscious expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Turin, Italy 10125
    J Neurosci 23:4315-23. 2003
    ....
  23. doi request reprint The placebo response: how words and rituals change the patient's brain
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, Turin, Italy
    Patient Educ Couns 84:413-9. 2011
    ..The study of the placebo effect and of its negative counterpart, the nocebo effect, is basically the study of the psychosocial context around the treatment and the patient, and it plays a crucial role in the therapeutic outcome...
  24. ncbi request reprint Dose-response relationship of opioids in nociceptive and neuropathic postoperative pain
    F Benedetti
    Department of Neuroscience, University of Torino Medical School, Italy
    Pain 74:205-11. 1998
    ..This suggests that, though neuropathic pain is indeed less sensitive to opioids, in some neuropathic patients a large amount of opioid resistance is already present in other painful conditions...
  25. ncbi request reprint Inducing placebo respiratory depressant responses in humans via opioid receptors
    F Benedetti
    Department of Neuroscience, University of Torino Medical School, Italy
    Eur J Neurosci 11:625-31. 1999
    ..Rather, it appears to be a sequence effect due to learning, thus suggesting a conditioning mechanism mediated by endogenous opioids...
  26. ncbi request reprint The specific effects of prior opioid exposure on placebo analgesia and placebo respiratory depression
    F Benedetti
    Department of Neuroscience, University of Torino Medical School, Italy
    Pain 75:313-9. 1998
    ....
  27. ncbi request reprint Pain threshold and tolerance in Alzheimer's disease
    F Benedetti
    Department of Neuroscience, CIND Center for the Neurophysiology of Pain, University of Torino Medical School, Italy
    Pain 80:377-82. 1999
    ..Thus, pain tolerance is tightly related to the severity of the disease according to the rule, 'the more severe the MMSE and EEG changes, the higher the tolerance to pain'...
  28. ncbi request reprint Postoperative pain and superficial abdominal reflexes after posterolateral thoracotomy
    F Benedetti
    Department of Neuroscience, CIND Center for the Neurophysiology of Pain, University of Torino Medical School, Italy
    Ann Thorac Surg 64:207-10. 1997
    ..This finding may be used as a predictor of patients with high analgesic requirements...
  29. ncbi request reprint Response variability to analgesics: a role for non-specific activation of endogenous opioids
    M Amanzio
    Department of Neuroscience, University of Torino Medical School, Corso Raffaello 30, 10125 Torino, Italy
    Pain 90:205-15. 2001
    ..Therefore, an important source of response variability to analgesics appears to be due to differences in non-specific activation of endogenous opioid systems...
  30. ncbi request reprint Neurophysiologic assessment of nerve impairment in posterolateral and muscle-sparing thoracotomy
    F Benedetti
    Department of Neuroscience, CIND Center for the Neurophysiology of Pain, University of Torino Medical School, Italy
    J Thorac Cardiovasc Surg 115:841-7. 1998
    ..In addition, because nerve impairment is responsible for the long-lasting neuropathic component of postoperative pain, it is necessary to match specific treatments to the neuropathic pain-generating mechanisms...
  31. ncbi request reprint Repeatability of autonomic responses to pain anticipation and pain stimulation
    Luana Colloca
    Department of Neuroscience, Clinical and Applied Physiology Program, University of Turin Medical School, Corso Raffaello 30, 10125 Turin, Italy
    Eur J Pain 10:659-65. 2006
    ....
  32. ncbi request reprint Placebo analgesia and the heart
    Antonella Pollo
    Department of Neuroscience, University of Turin Medical School, Corso Raffaello 30, 10125 Turin, Italy
    Pain 102:125-33. 2003
    ..15 Hz) spectral component was reduced during placebo analgesia, an effect that was reversed by naloxone. These findings indicate that placebo analgesia is accompanied by a complex cascade of events which affect the cardiovascular system...
  33. ncbi request reprint Expectation enhances autonomic responses to stimulation of the human subthalamic limbic region
    Michele Lanotte
    Department of Neuroscience, University of Turin Medical School, Turin, Italy
    Brain Behav Immun 19:500-9. 2005
    ..In light of the interactions between the sympathetic adrenergic system and the immune system, the open-hidden difference in autonomic responses might be relevant to the understanding of how expectations might affect the immune system...
  34. doi request reprint The role of learning in nocebo and placebo effects
    L Colloca
    Department of Neuroscience, University of Turin Medical School, and National Institute of Neuroscience, Corso Raffaello 30, 10125 Turin, Italy
    Pain 136:211-8. 2008
    ..These results also suggest that learning is not important in nocebo hyperalgesia compared to placebo analgesia...
  35. ncbi request reprint Response expectancies in placebo analgesia and their clinical relevance
    A Pollo
    Department of Neuroscience, University of Torino Medical School, 10125 Torino, Italy
    Pain 93:77-84. 2001
    ....
  36. ncbi request reprint Quantitative EEG responses to ischaemic arm stress in migraine
    I Rainero
    Neurology II Headache Center, Department of Neuroscience, University of Turin Medical School, Torino, Italy
    Cephalalgia 21:224-9. 2001
    ..The results of our study show that migraine sufferers display a lower threshold to physical stress and confirm previous studies indicating that migraine is a disease characterized by a state of altered neuronal excitability...
  37. doi request reprint Prospective, multicenter randomized GITMO/IIL trial comparing intensive (R-HDS) versus conventional (CHOP-R) chemoimmunotherapy in high-risk follicular lymphoma at diagnosis: the superior disease control of R-HDS does not translate into an overall surviva
    Marco Ladetto
    Divisione Universitaria di Ematologia, Cattedra di Ematologia, Torino, Italy
    Blood 111:4004-13. 2008
    ..This trial was registered at www.clinicaltrials.gov as no. NCT00435955...
  38. ncbi request reprint Prolonged survival and low incidence of late toxic sequelae in advanced follicular lymphoma treated with a TBI-free autografting program: updated results of the multicenter consecutive GITMO trial
    M Ladetto
    Divisione Universitaria di Ematologia, Cattedra di Ematologia, Torino, Italy
    Leukemia 20:1840-7. 2006
    ..As the HDS schedule can be easily supplemented with Rituximab, it is one of the best options for random comparison with Rituximab-supplemented conventional chemotherapy...
  39. doi request reprint A systematic review of adverse events in placebo groups of anti-migraine clinical trials
    Martina Amanzio
    Department of Psychology, University of Turin, Via Verdi 10, 10123 Turin, Italy
    Pain 146:261-9. 2009
    ..These findings are in accordance with the expectation theory of placebo and nocebo effects...
  40. doi request reprint The top-down influence of ergogenic placebos on muscle work and fatigue
    Antonella Pollo
    Istituto Nazionale di Neuroscienze and Dipartimento di Neuroscienze, Universita di Torino, Corso Raffaello 30, 10125, Torino, Italy
    Eur J Neurosci 28:379-88. 2008
    ..In addition, the difference between the first and second experiment underscores the role of learning in increasing muscle performance with placebos...
  41. pmc How the number of learning trials affects placebo and nocebo responses
    Luana Colloca
    Department of Neuroscience, University of Turin Medical School and National Institute of Neuroscience, Turin, Italy
    Pain 151:430-9. 2010
    ..These findings suggest that the strength of learning may be clinically important for producing long-lasting placebo effects...
  42. doi request reprint Learning potentiates neurophysiological and behavioral placebo analgesic responses
    Luana Colloca
    Department of Neuroscience, University of Turin Medical School, and National Institute of Neuroscience, Turin, Italy
    Pain 139:306-14. 2008
    ....
  43. doi request reprint Placebo analgesia induced by social observational learning
    Luana Colloca
    Department of Neuroscience, University of Turin Medical School, National Institute of Neuroscience, Turin, Italy
    Pain 144:28-34. 2009
    ..These findings show that placebo analgesia is finely tuned by social observation and suggest that different forms of learning take part in the placebo phenomenon...
  44. ncbi request reprint Neurobiological mechanisms of the placebo effect
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, 10125 Turin, Italy
    J Neurosci 25:10390-402. 2005
  45. ncbi request reprint Experimental designs and brain mapping approaches for studying the placebo analgesic effect
    Luana Colloca
    Department of Neuroscience, University of Turin Medical School and National Institute of Neuroscience, Corso Raffaello 30, 10125, Turin, Italy
    Eur J Appl Physiol 102:371-80. 2008
    ..The understanding of placebo mechanisms is fundamental and necessary to identify ways of accessing and harnessing these mechanisms in clinical practice to the patient's benefit...
  46. ncbi request reprint Electroencephalographic responses to intraoperative subthalamic stimulation
    Luana Colloca
    Department of Neuroscience, University of Turin Medical School, Turin bS Maugeri Foundation, Pavia, Italy
    Neuroreport 17:1465-8. 2006
    ....
  47. doi request reprint The placebo response: neurobiological and clinical issues of neurological relevance
    Antonella Pollo
    Department of Neuroscience, Faculty of Pharmacy, University of Turin, Turin, Italy
    Prog Brain Res 175:283-94. 2009
    ....
  48. ncbi request reprint Overt versus covert treatment for pain, anxiety, and Parkinson's disease
    Luana Colloca
    University of Turin Medical School, Turin, Italy
    Lancet Neurol 3:679-84. 2004
    ..In addition, by use of covert administration, the efficacy of some treatments can be assessed without the use of a placebo and associated ethical issues...
  49. doi request reprint Placebo response: relevance to the rheumatic diseases
    Antonella Pollo
    Department of Neuroscience, University of Turin, Faculty of Pharmacy, Corso Raffaello 30, I 10125 Turin, Italy
    Rheum Dis Clin North Am 34:331-49. 2008
    ....
  50. ncbi request reprint Nocebo hyperalgesia: how anxiety is turned into pain
    Luana Colloca
    Department of Neuroscience, University of Turin Medical School and National Institute of Neuroscience, Corso Raffaello 30, 10125 Turin, Italy
    Curr Opin Anaesthesiol 20:435-9. 2007
    ..Here, we highlight recent advances in our understanding of the neurobiology of the nocebo hyperalgesic effect...
  51. ncbi request reprint Placebos and painkillers: is mind as real as matter?
    Luana Colloca
    Department of Neuroscience, Clinical and Applied Physiology Program, University of Turin Medical School, Corso Raffaello 30, 10125 Turin, Italy
    Nat Rev Neurosci 6:545-52. 2005
    ..These new neurobiological advances are already changing our conception of how clinical trials and medical practice must be viewed and conducted...
  52. ncbi request reprint Temporal changes in movement time during the switch of the stimulators in Parkinson's disease patients treated by subthalamic nucleus stimulation
    Leonardo Lopiano
    Department of Neuroscience, University of Turin, Italy
    Eur Neurol 50:94-9. 2003
    ..The aim of the study was the assessment of the effectiveness of STN DBS on bradykinesia by the analysis of movement time (MT) in 2 conditions: with the stimulators turned on ('stim-on') or off ('stim-off')...
  53. ncbi request reprint Decreased sensitivity of 5-HT1D receptors in chronic tension-type headache
    I Rainero
    Neurology III Headache Center, Department of Neuroscience, University of Turin, Italy
    Headache 42:709-14. 2002
    ..To assess the sensitivity of 5-HT1D receptors in chronic tension-type headache using sumatriptan as a pharmacological probe...
  54. ncbi request reprint How the doctor's words affect the patient's brain
    Fabrizio Benedetti
    University of Turin Medical School
    Eval Health Prof 25:369-86. 2002
    ..All these studies, taken together, lead to a neurobiological understanding of the events occurring in the brain during the interaction between the therapist and his or her patient...
  55. ncbi request reprint What do you expect from this treatment? Changing our mind about clinical trials
    Fabrizio Benedetti
    Pain 128:193-4. 2007
  56. ncbi request reprint Placebos and treatment of pain
    Mark Sullivan
    Pain Med 5:325-8. 2004
  57. ncbi request reprint The importance of considering the effects of perceived group assignment in placebo-controlled trials
    Fabrizio Benedetti
    Eval Health Prof 28:5-6. 2005
  58. ncbi request reprint Mechanisms of the placebo response and their impact on clinical trials and clinical practice
    Damien G Finniss
    Pain Management Research Institute, University of Sydney and Royal North Shore Hospital, 2065 Sydney, NSW, Australia
    Pain 114:3-6. 2005
  59. doi request reprint New insights into the placebo and nocebo responses
    Paul Enck
    Department of Internal Medicine VI Psychosomatic Medicine and Psychotherapy, University Hospital, 72076 Tubingen, Germany
    Neuron 59:195-206. 2008
    ....
  60. ncbi request reprint A comprehensive review of the placebo effect: recent advances and current thought
    Donald D Price
    Division of Neuroscience, Oral and Maxillofacial Surgery, University of Florida, Gainesville, Florida 32610 0416, USA
    Annu Rev Psychol 59:565-90. 2008
    ....
  61. pmc Recent developments in pain in dementia
    Erik Scherder
    Centre of Human Movement Sciences, Rijksuniversiteit Groningen, A Deusinglaan 1, 9713 AV Groningen, Netherlands
    BMJ 330:461-4. 2005